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Aliases for TOX2 Gene

Aliases for TOX2 Gene

  • TOX High Mobility Group Box Family Member 2 2 3 5
  • Granulosa Cell HMG Box 1 2 3
  • C20orf100 3 4
  • GCX-1 3 4
  • GCX1 3 4
  • Chromosome 20 Open Reading Frame 100 2
  • Granulosa Cell HMG Box Protein 1 4
  • DJ1108D11.2 3
  • DJ495O3.1 3

External Ids for TOX2 Gene

Previous HGNC Symbols for TOX2 Gene

  • C20orf100

Previous GeneCards Identifiers for TOX2 Gene

  • GC20P041978
  • GC20P042543
  • GC20P039278

Summaries for TOX2 Gene

GeneCards Summary for TOX2 Gene

TOX2 (TOX High Mobility Group Box Family Member 2) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and RNA polymerase II transcription factor binding. An important paralog of this gene is TOX.

UniProtKB/Swiss-Prot for TOX2 Gene

  • Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOX2 Gene

Genomics for TOX2 Gene

Regulatory Elements for TOX2 Gene

Enhancers for TOX2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TOX2 on UCSC Golden Path with GeneCards custom track

Promoters for TOX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TOX2 Gene

Chromosome:
20
Start:
43,914,852 bp from pter
End:
44,069,616 bp from pter
Size:
154,765 bases
Orientation:
Plus strand

Genomic View for TOX2 Gene

Genes around TOX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOX2 Gene

Proteins for TOX2 Gene

  • Protein details for TOX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NM4-TOX2_HUMAN
    Recommended name:
    TOX high mobility group box family member 2
    Protein Accession:
    Q96NM4
    Secondary Accessions:
    • A8K1J1
    • E1P5X0
    • G3XAC7
    • Q5TE33
    • Q5TE34
    • Q5TE35
    • Q96IC9
    • Q9BQN5

    Protein attributes for TOX2 Gene

    Size:
    488 amino acids
    Molecular mass:
    51604 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TOX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TOX2 Gene

Post-translational modifications for TOX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TOX2 Gene

Domains & Families for TOX2 Gene

Protein Domains for TOX2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TOX2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96NM4

UniProtKB/Swiss-Prot:

TOX2_HUMAN :
  • Contains 1 HMG box DNA-binding domain.
Domain:
  • Contains 1 HMG box DNA-binding domain.
genes like me logo Genes that share domains with TOX2: view

No data available for Gene Families for TOX2 Gene

Function for TOX2 Gene

Molecular function for TOX2 Gene

UniProtKB/Swiss-Prot Function:
Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system.

Gene Ontology (GO) - Molecular Function for TOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001085 RNA polymerase II transcription factor binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TOX2: view
genes like me logo Genes that share phenotypes with TOX2: view

Animal Model Products

CRISPR Products

miRNA for TOX2 Gene

miRTarBase miRNAs that target TOX2

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TOX2 Gene

Localization for TOX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOX2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TOX2 Gene COMPARTMENTS Subcellular localization image for TOX2 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for TOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with TOX2: view

Pathways & Interactions for TOX2 Gene

SuperPathways for TOX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0008585 female gonad development IEA --
GO:0034698 response to gonadotropin IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with TOX2: view

No data available for Pathways by source and SIGNOR curated interactions for TOX2 Gene

Drugs & Compounds for TOX2 Gene

No Compound Related Data Available

Transcripts for TOX2 Gene

Unigene Clusters for TOX2 Gene

TOX high mobility group box family member 2:
Representative Sequences:

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOX2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: - -
SP2: -
SP3: - -
SP4: - - -
SP5: - - -
SP6:
SP7:

Relevant External Links for TOX2 Gene

GeneLoc Exon Structure for
TOX2
ECgene alternative splicing isoforms for
TOX2

Expression for TOX2 Gene

mRNA expression in normal human tissues for TOX2 Gene

mRNA differential expression in normal tissues according to GTEx for TOX2 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x4.7).

Protein differential expression in normal tissues from HIPED for TOX2 Gene

This gene is overexpressed in Heart (57.3) and Testis (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TOX2 Gene



Protein tissue co-expression partners for TOX2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TOX2 Gene:

TOX2

SOURCE GeneReport for Unigene cluster for TOX2 Gene:

Hs.26608
genes like me logo Genes that share expression patterns with TOX2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TOX2 Gene

Orthologs for TOX2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TOX2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TOX2 34
  • 91.33 (n)
  • 94.96 (a)
TOX2 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TOX2 34
  • 91.5 (n)
  • 95.45 (a)
TOX2 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tox2 34
  • 88.29 (n)
  • 91.81 (a)
Tox2 16
Tox2 35
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TOX2 34
  • 99.5 (n)
  • 99.78 (a)
TOX2 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tox2 34
  • 88.1 (n)
  • 92.14 (a)
oppossum
(Monodelphis domestica)
Mammalia TOX2 35
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TOX2 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves TOX2 34
  • 75.8 (n)
  • 74.6 (a)
TOX2 35
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TOX2 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tox2 34
  • 70.41 (n)
  • 68.67 (a)
zebrafish
(Danio rerio)
Actinopterygii tox2 34
  • 67.67 (n)
  • 63.29 (a)
CABZ01086220.1 35
  • 58 (a)
OneToMany
TOX2 (2 of 2) 35
  • 55 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POB3 35
  • 5 (a)
OneToMany
Species where no ortholog for TOX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TOX2 Gene

ENSEMBL:
Gene Tree for TOX2 (if available)
TreeFam:
Gene Tree for TOX2 (if available)

Paralogs for TOX2 Gene

Paralogs for TOX2 Gene

(3) SIMAP similar genes for TOX2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TOX2: view

Variants for TOX2 Gene

Sequence variations from dbSNP and Humsavar for TOX2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs6103584 - 44,051,535(+) GGAAG(C/T)GCATT nc-transcript-variant, reference, missense
rs910907 -- 43,948,358(-) CTGGA(A/C)TCTTC intron-variant
rs910908 -- 43,947,201(-) ATGGC(C/T)GAGCT intron-variant
rs910909 -- 43,947,159(-) CAGTA(C/T)ACAGT intron-variant
rs916474 -- 43,934,931(+) TTGCT(A/G)TAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TOX2 Gene

Variant ID Type Subtype PubMed ID
dgv2255n106 CNV deletion 24896259
dgv97n6 CNV deletion 16902084
esv1000157 CNV insertion 20482838
esv1002187 CNV deletion 20482838
esv1006545 CNV insertion 20482838
esv1140542 CNV insertion 17803354
esv1734532 CNV deletion 17803354
esv1996686 CNV deletion 18987734
esv2487128 CNV deletion 19546169
esv2666708 CNV deletion 23128226
esv2722440 CNV deletion 23290073
esv3327240 CNV duplication 20981092
esv3380916 CNV duplication 20981092
esv3444819 CNV duplication 20981092
esv3557108 CNV deletion 23714750
esv3645899 CNV loss 21293372
esv5288 CNV loss 18987735
esv8556 CNV loss 19470904
nsv1057847 CNV loss 25217958
nsv1072116 CNV deletion 25765185
nsv1073061 CNV deletion 25765185
nsv1145873 CNV deletion 26484159
nsv3386 CNV deletion 18451855
nsv479158 CNV novel sequence insertion 20440878
nsv480186 CNV novel sequence insertion 20440878
nsv509770 CNV insertion 20534489
nsv524229 CNV gain 19592680
nsv833989 CNV loss 17160897
nsv956199 CNV deletion 24416366

Variation tolerance for TOX2 Gene

Residual Variation Intolerance Score: 63.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.36; 63.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TOX2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TOX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOX2 Gene

Disorders for TOX2 Gene

Relevant External Links for TOX2

Genetic Association Database (GAD)
TOX2
Human Genome Epidemiology (HuGE) Navigator
TOX2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TOX2

No disorders were found for TOX2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TOX2 Gene

Publications for TOX2 Gene

  1. Genome-wide association study of conduct disorder symptomatology. (PMID: 20585324) Dick D.M. … Bierut L. (Mol. Psychiatry 2011) 3 46 65
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 65
  4. Cloning and characterization of granulosa cell high-mobility group (HMG)-box protein-1, a novel HMG-box transcriptional regulator strongly expressed in rat ovarian granulosa cells. (PMID: 14764631) Kajitani T. … Miyamoto K. (Endocrinology 2004) 2 3 65
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65

Products for TOX2 Gene

Sources for TOX2 Gene

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