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Aliases for TOX2 Gene

Aliases for TOX2 Gene

  • TOX High Mobility Group Box Family Member 2 2 3 5
  • Granulosa Cell HMG Box 1 2 3
  • C20orf100 3 4
  • GCX-1 3 4
  • GCX1 3 4
  • Chromosome 20 Open Reading Frame 100 2
  • Granulosa Cell HMG Box Protein 1 4
  • DJ1108D11.2 3
  • DJ495O3.1 3

External Ids for TOX2 Gene

Previous HGNC Symbols for TOX2 Gene

  • C20orf100

Previous GeneCards Identifiers for TOX2 Gene

  • GC20P041978
  • GC20P042543
  • GC20P039278

Summaries for TOX2 Gene

GeneCards Summary for TOX2 Gene

TOX2 (TOX High Mobility Group Box Family Member 2) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and RNA polymerase II transcription factor binding. An important paralog of this gene is TOX4.

UniProtKB/Swiss-Prot for TOX2 Gene

  • Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOX2 Gene

Genomics for TOX2 Gene

Regulatory Elements for TOX2 Gene

Enhancers for TOX2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TOX2 on UCSC Golden Path with GeneCards custom track

Promoters for TOX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TOX2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TOX2 Gene

43,914,852 bp from pter
44,069,616 bp from pter
154,765 bases
Plus strand

Genomic View for TOX2 Gene

Genes around TOX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOX2 Gene

Proteins for TOX2 Gene

  • Protein details for TOX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TOX high mobility group box family member 2
    Protein Accession:
    Secondary Accessions:
    • A8K1J1
    • E1P5X0
    • G3XAC7
    • Q5TE33
    • Q5TE34
    • Q5TE35
    • Q96IC9
    • Q9BQN5

    Protein attributes for TOX2 Gene

    488 amino acids
    Molecular mass:
    51604 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TOX2 Gene


neXtProt entry for TOX2 Gene

Proteomics data for TOX2 Gene at MOPED

Post-translational modifications for TOX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TOX2 Gene

Domains & Families for TOX2 Gene

Protein Domains for TOX2 Gene


Suggested Antigen Peptide Sequences for TOX2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 HMG box DNA-binding domain.
  • Contains 1 HMG box DNA-binding domain.
genes like me logo Genes that share domains with TOX2: view

No data available for Gene Families for TOX2 Gene

Function for TOX2 Gene

Molecular function for TOX2 Gene

UniProtKB/Swiss-Prot Function:
Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system.
genes like me logo Genes that share phenotypes with TOX2: view

Animal Model Products

miRNA for TOX2 Gene

miRTarBase miRNAs that target TOX2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TOX2 Gene

Localization for TOX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOX2 Gene

Subcellular locations from

Jensen Localization Image for TOX2 Gene COMPARTMENTS Subcellular localization image for TOX2 gene
Compartment Confidence
nucleus 5
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for TOX2 Gene

Pathways & Interactions for TOX2 Gene

SuperPathways for TOX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with TOX2: view

No data available for Pathways by source and SIGNOR curated interactions for TOX2 Gene

Drugs & Compounds for TOX2 Gene

No Compound Related Data Available

Transcripts for TOX2 Gene

Unigene Clusters for TOX2 Gene

TOX high mobility group box family member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TOX2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: - -
SP2: -
SP3: - -
SP4: - - -
SP5: - - -

Relevant External Links for TOX2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TOX2 Gene

mRNA expression in normal human tissues for TOX2 Gene

mRNA differential expression in normal tissues according to GTEx for TOX2 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x4.7).

Protein differential expression in normal tissues from HIPED for TOX2 Gene

This gene is overexpressed in Heart (57.3) and Testis (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TOX2 Gene

SOURCE GeneReport for Unigene cluster for TOX2 Gene Hs.26608

genes like me logo Genes that share expression patterns with TOX2: view

Protein tissue co-expression partners for TOX2 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TOX2 Gene

Orthologs for TOX2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TOX2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TOX2 35
  • 91.33 (n)
  • 94.96 (a)
TOX2 36
  • 91 (a)
(Canis familiaris)
Mammalia TOX2 35
  • 91.5 (n)
  • 95.45 (a)
TOX2 36
  • 88 (a)
(Mus musculus)
Mammalia Tox2 35
  • 88.29 (n)
  • 91.81 (a)
Tox2 16
Tox2 36
  • 84 (a)
(Pan troglodytes)
Mammalia TOX2 35
  • 99.5 (n)
  • 99.78 (a)
TOX2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tox2 35
  • 88.1 (n)
  • 92.14 (a)
(Monodelphis domestica)
Mammalia TOX2 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia TOX2 36
  • 70 (a)
(Gallus gallus)
Aves TOX2 35
  • 75.8 (n)
  • 74.6 (a)
TOX2 36
  • 75 (a)
(Anolis carolinensis)
Reptilia TOX2 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tox2 35
  • 70.41 (n)
  • 68.67 (a)
(Danio rerio)
Actinopterygii tox2 35
  • 67.67 (n)
  • 63.29 (a)
CABZ01086220.1 36
  • 58 (a)
TOX2 (2 of 2) 36
  • 55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POB3 36
  • 5 (a)
Species with no ortholog for TOX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TOX2 Gene

Gene Tree for TOX2 (if available)
Gene Tree for TOX2 (if available)

Paralogs for TOX2 Gene

Paralogs for TOX2 Gene

(3) SIMAP similar genes for TOX2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TOX2: view

Variants for TOX2 Gene

Sequence variations from dbSNP and Humsavar for TOX2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs6103584 - 44,051,535(+) GGAAG(C/T)GCATT nc-transcript-variant, reference, missense
rs976327 -- 44,014,289(-) gggct(A/G)gggca intron-variant
rs1040545 -- 44,039,893(-) CCCTC(A/G)GCACC intron-variant
rs1040546 -- 44,039,748(-) TCTGA(C/T)TTGCG intron-variant
rs1040547 -- 44,039,586(-) gggtt(A/C)acccc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TOX2 Gene

Variant ID Type Subtype PubMed ID
nsv833989 CNV Loss 17160897
esv1006545 CNV Insertion 20482838
esv2666708 CNV Deletion 23128226
nsv509770 CNV Insertion 20534489
nsv524229 CNV Gain 19592680
esv1000157 CNV Insertion 20482838
esv1140542 CNV Insertion 17803354
esv2487128 CNV Deletion 19546169
esv1996686 CNV Deletion 18987734
esv5288 CNV Deletion 18987735
esv2722440 CNV Deletion 23290073
dgv97n6 CNV Loss 16902084
esv1002187 CNV Deletion 20482838
esv1734532 CNV Deletion 17803354
esv8556 CNV Loss 19470904
nsv3386 CNV Loss 18451855

Variation tolerance for TOX2 Gene

Residual Variation Intolerance Score: 63.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.36; 63.36% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TOX2 Gene

Disorders for TOX2 Gene

Relevant External Links for TOX2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TOX2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TOX2 Gene

Publications for TOX2 Gene

  1. Genome-wide association study of conduct disorder symptomatology. (PMID: 20585324) Dick D.M. … Bierut L. (Mol. Psychiatry 2011) 3 48 67
  2. Cloning and characterization of granulosa cell high-mobility group (HMG)-box protein-1, a novel HMG-box transcriptional regulator strongly expressed in rat ovarian granulosa cells. (PMID: 14764631) Kajitani T. … Miyamoto K. (Endocrinology 2004) 2 3
  3. TOX2 regulates human natural killer cell development by controlling T-BET expression. (PMID: 25352127) Vong Q.P. … Leung W. (Blood 2014) 3
  4. Differential Epigenetic Regulation of TOX Subfamily High Mobility Group Box Genes in Lung and Breast Cancers. (PMID: 22496870) Tessema M. … Belinsky S.A. (PLoS ONE 2012) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for TOX2 Gene

Sources for TOX2 Gene