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Aliases for TOX2 Gene

Aliases for TOX2 Gene

  • TOX High Mobility Group Box Family Member 2 2 3
  • C20orf100 3 4 6
  • GCX1 3 4 6
  • Granulosa Cell HMG Box 1 2 3
  • GCX-1 3 4
  • Chromosome 20 Open Reading Frame 100 2
  • Granulosa Cell HMG Box Protein 1 4
  • DJ1108D11.2 3
  • DJ495O3.1 3

External Ids for TOX2 Gene

Previous HGNC Symbols for TOX2 Gene

  • C20orf100

Previous GeneCards Identifiers for TOX2 Gene

  • GC20P041978
  • GC20P042543
  • GC20P039278

Summaries for TOX2 Gene

GeneCards Summary for TOX2 Gene

TOX2 (TOX High Mobility Group Box Family Member 2) is a Protein Coding gene. GO annotations related to this gene include RNA polymerase II transcription factor binding. An important paralog of this gene is SSRP1.

UniProtKB/Swiss-Prot for TOX2 Gene

  • Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOX2 Gene

Genomics for TOX2 Gene

Regulatory Elements for TOX2 Gene

Genomic Location for TOX2 Gene

Start:
43,914,852 bp from pter
End:
44,069,616 bp from pter
Size:
154,765 bases
Orientation:
Plus strand

Genomic View for TOX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TOX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOX2 Gene

Proteins for TOX2 Gene

  • Protein details for TOX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NM4-TOX2_HUMAN
    Recommended name:
    TOX high mobility group box family member 2
    Protein Accession:
    Q96NM4
    Secondary Accessions:
    • A8K1J1
    • E1P5X0
    • G3XAC7
    • Q5TE33
    • Q5TE34
    • Q5TE35
    • Q96IC9
    • Q9BQN5

    Protein attributes for TOX2 Gene

    Size:
    488 amino acids
    Molecular mass:
    51604 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TOX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TOX2 Gene

Proteomics data for TOX2 Gene at MOPED

Post-translational modifications for TOX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TOX2 Gene

Domains for TOX2 Gene

Protein Domains for TOX2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TOX2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96NM4

UniProtKB/Swiss-Prot:

TOX2_HUMAN :
  • Q96NM4
Domain:
  • Contains 1 HMG box DNA-binding domain.
genes like me logo Genes that share domains with TOX2: view

No data available for Gene Families for TOX2 Gene

Function for TOX2 Gene

Molecular function for TOX2 Gene

UniProtKB/Swiss-Prot Function: Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system

Gene Ontology (GO) - Molecular Function for TOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001085 RNA polymerase II transcription factor binding IEA --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IBA --
genes like me logo Genes that share ontologies with TOX2: view

miRNA for TOX2 Gene

miRTarBase miRNAs that target TOX2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TOX2 Gene

Localization for TOX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOX2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TOX2 Gene COMPARTMENTS Subcellular localization image for TOX2 gene
Compartment Confidence
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for TOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with TOX2: view

Pathways for TOX2 Gene

SuperPathways for TOX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0008585 female gonad development IEA --
GO:0034698 response to gonadotropin IEA --
genes like me logo Genes that share ontologies with TOX2: view

No data available for Pathways by source for TOX2 Gene

Transcripts for TOX2 Gene

Unigene Clusters for TOX2 Gene

TOX high mobility group box family member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TOX2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: - -
SP2: -
SP3: - -
SP4: - - -
SP5: - - -
SP6:
SP7:

Relevant External Links for TOX2 Gene

GeneLoc Exon Structure for
TOX2
ECgene alternative splicing isoforms for
TOX2

Expression for TOX2 Gene

mRNA expression in normal human tissues for TOX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TOX2 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TOX2 Gene

SOURCE GeneReport for Unigene cluster for TOX2 Gene Hs.26608

genes like me logo Genes that share expressions with TOX2: view

No data available for mRNA Expression by UniProt/SwissProt for TOX2 Gene

Orthologs for TOX2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TOX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOX2 35
  • 99.5 (n)
  • 99.78 (a)
TOX2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TOX2 35
  • 91.33 (n)
  • 94.96 (a)
TOX2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TOX2 35
  • 91.5 (n)
  • 95.45 (a)
TOX2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tox2 35
  • 88.29 (n)
  • 91.81 (a)
Tox2 16
Tox2 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TOX2 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TOX2 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tox2 35
  • 88.1 (n)
  • 92.14 (a)
chicken
(Gallus gallus)
Aves TOX2 35
  • 75.8 (n)
  • 74.6 (a)
TOX2 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TOX2 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tox2 35
  • 70.41 (n)
  • 68.67 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01086220.1 36
  • 58 (a)
OneToMany
tox2 35
  • 67.67 (n)
  • 63.29 (a)
TOX2 (2 of 2) 36
  • 55 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POB3 36
  • 5 (a)
OneToMany
Species with no ortholog for TOX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TOX2 Gene

ENSEMBL:
Gene Tree for TOX2 (if available)
TreeFam:
Gene Tree for TOX2 (if available)

Paralogs for TOX2 Gene

Paralogs for TOX2 Gene

Selected SIMAP similar genes for TOX2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TOX2: view

Variants for TOX2 Gene

Sequence variations from dbSNP and Humsavar for TOX2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs733748 -- 44,036,507(-) CAGTT(A/G/T)CTTCT intron-variant
rs733749 -- 44,036,573(-) GAAGC(A/G)ATGGT intron-variant
rs736992 -- 43,969,520(-) CCTGG(C/G)GCTTA intron-variant
rs742640 -- 43,926,041(+) CTTAT(C/T)TCGAA intron-variant
rs742641 -- 43,926,208(+) GGGCC(C/T)TTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TOX2 Gene

Variant ID Type Subtype PubMed ID
nsv833989 CNV Loss 17160897
esv1006545 CNV Insertion 20482838
esv2666708 CNV Deletion 23128226
nsv509770 CNV Insertion 20534489
nsv524229 CNV Gain 19592680
esv1000157 CNV Insertion 20482838
esv1140542 CNV Insertion 17803354
esv2487128 CNV Deletion 19546169
esv1996686 CNV Deletion 18987734
esv5288 CNV Deletion 18987735
esv2722440 CNV Deletion 23290073
dgv97n6 CNV Loss 16902084
esv1002187 CNV Deletion 20482838
esv1734532 CNV Deletion 17803354
esv8556 CNV Loss 19470904
nsv3386 CNV Loss 18451855

Relevant External Links for TOX2 Gene

HapMap Linkage Disequilibrium report
TOX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOX2 Gene

Disorders for TOX2 Gene

Relevant External Links for TOX2

Genetic Association Database (GAD)
TOX2
Human Genome Epidemiology (HuGE) Navigator
TOX2
genes like me logo Genes that share disorders with TOX2: view

No data available for UniProtKB/Swiss-Prot for TOX2 Gene

Publications for TOX2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Cloning and characterization of granulosa cell high-mobility group (HMG)-box protein-1, a novel HMG-box transcriptional regulator strongly expressed in rat ovarian granulosa cells. (PMID: 14764631) Kajitani T. … Miyamoto K. (Endocrinology 2004) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for TOX2 Gene

Sources for TOX2 Gene

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