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TOX2 Gene

protein-coding   GIFtS: 49
GCID: GC20P042543

TOX High Mobility Group Box Family Member 2

(Previous name: chromosome 20 open reading frame 100)
(Previous symbol: C20orf100)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TOX High Mobility Group Box Family Member 21 2     Chromosome 20 Open Reading Frame 1001
C20orf1001 2 3 5     dJ1108D11.22
GCX12 3 5     dJ495O3.12
Granulosa Cell HMG Box 11 2     Granulosa Cell HMG Box Protein 13
GCX-12 3     

External Ids:    HGNC: 160951   Entrez Gene: 849692   Ensembl: ENSG000001241917   OMIM: 6111635   UniProtKB: Q96NM43   

Export aliases for TOX2 gene to outside databases

Previous GC identifers: GC20P041978 GC20P039278


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TOX2 Gene:
TOX2 (TOX high mobility group box family member 2) is a protein-coding gene. GO annotations related to this gene include RNA polymerase II transcription factor binding. An important paralog of this gene is TOX.

UniProtKB/Swiss-Prot: TOX2_HUMAN, Q96NM4
Function: Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TOX2 gene promoter:
         GATA-3   COMP1   Nkx2-5   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTOX2 promoter sequence
   Search Chromatin IP Primers for TOX2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TOX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.12

TOX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOX2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P042543:  view genomic region     (about GC identifiers)

Start:
42,543,492 bp from pter      End:
42,698,256 bp from pter
Size:
154,765 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TOX2_HUMAN, Q96NM4 (See protein sequence)
Recommended Name: TOX high mobility group box family member 2  
Size: 488 amino acids; 51604 Da
Caution: It is uncertain whether Met-1 or Met-52 is the initiator
Secondary accessions: A8K1J1 E1P5X0 G3XAC7 Q5TE33 Q5TE34 Q5TE35 Q96IC9 Q9BQN5
Alternative splicing: 4 isoforms:  Q96NM4-1   Q96NM4-2   Q96NM4-3   Q96NM4-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TOX2: NX_Q96NM4

Explore proteomics data for TOX2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TOX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001092266.1  NP_001092267.1  NP_001092268.1  NP_116272.1  

    ENSEMBL proteins: 
     ENSP00000344724   ENSP00000390278   ENSP00000362090   ENSP00000350849   ENSP00000390876  

    TOX2 Human Recombinant Protein Products:

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    OriGene Purified Protein for TOX2
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    OriGene MassSpec for TOX2
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    GenScript Custom Purified and Recombinant Proteins Services for TOX2
    Novus Biologicals TOX2 Protein
    Novus Biologicals TOX2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TOX2

     
    Search eBioscience for Proteins for TOX2 

    TOX2 Antibody Products:

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    Abcam antibodies for TOX2
    Cloud-Clone Corp. Antibodies for TOX2
    Search ThermoFisher Antibodies for TOX2
    LSBio Antibodies in human, mouse, rat for TOX2

    TOX2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TOX2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TOX2
    Cloud-Clone Corp. CLIAs for TOX2
    Search eBioscience for ELISAs for TOX2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009071 HMG_box_dom

    Graphical View of Domain Structure for InterPro Entry Q96NM4

    ProtoNet protein and cluster: Q96NM4

    UniProtKB/Swiss-Prot: TOX2_HUMAN, Q96NM4
    Similarity: Contains 1 HMG box DNA-binding domain


    Find genes that share domains with TOX2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TOX2_HUMAN, Q96NM4
    Function: Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001085RNA polymerase II transcription factor binding IEA--
    GO:0003677DNA binding IEA--
         
    Find genes that share ontologies with TOX2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TOX2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TOX2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TOX2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TOX2

    miRNA
    Products:
        
    miRTarBase miRNAs that target TOX2:
    hsa-mir-335-5p (MIRT017087)

    Block miRNA regulation of human, mouse, rat TOX2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TOX2 (see all 20):
    hsa-miR-142-5p hsa-miR-4291 hsa-miR-4254 hsa-miR-185* hsa-miR-657 hsa-miR-1271 hsa-miR-340 hsa-miR-606
    SwitchGear 3'UTR luciferase reporter plasmidTOX2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TOX2
    Predesigned siRNA for gene silencing in human, mouse, rat TOX2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TOX2

    Clone
    Products:
         
    OriGene clones in human, mouse for TOX2 (see all 23)
    OriGene ORF clones in mouse, rat for TOX2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TOX2 (NM_020225)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOX2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TOX2
    Browse ESI BIO Cell Lines and PureStem Progenitors for TOX2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOX2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TOX2_HUMAN, Q96NM4: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with TOX2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TOX2
    Interactions:

        Search GeneGlobe Interaction Network for TOX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for TOX2 (ENSP000003447244) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF461ENSP000003535154STRING: ENSP00000353515
    UMPSENSP000002326074STRING: ENSP00000232607
    XRCC6ENSP000003522574STRING: ENSP00000352257
    UBCENSP000003448184STRING: ENSP00000344818
    ACTR5ENSP000002439034STRING: ENSP00000243903
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0008585female gonad development IEA--
    GO:0034698response to gonadotropin IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--

    Find genes that share ontologies with TOX2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TOX2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TOX2 gene (4 alternative transcripts): 
    NM_001098796.1  NM_001098797.1  NM_001098798.1  NM_032883.2  

    Unigene Cluster for TOX2:

    TOX high mobility group box family member 2
    Hs.26608  [show with all ESTs]
    Unigene Representative Sequence: AK055135
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341197(uc010ggo.3) ENST00000423191(uc010ggp.3) ENST00000372999(uc002xle.4)
    ENST00000358131(uc002xlf.4) ENST00000435864(uc010zwk.2) ENST00000413823

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TOX2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TOX2 (see all 20):
    hsa-miR-142-5p hsa-miR-4291 hsa-miR-4254 hsa-miR-185* hsa-miR-657 hsa-miR-1271 hsa-miR-340 hsa-miR-606
    SwitchGear 3'UTR luciferase reporter plasmidTOX2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TOX2
    Predesigned siRNA for gene silencing in human, mouse, rat TOX2
    Clone
    Products:
         
    OriGene clones in human, mouse for TOX2 (see all 23)
    OriGene ORF clones in mouse, rat for TOX2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TOX2 (NM_020225)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOX2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TOX2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TOX2
      QuantiTect SYBR Green Assays in human, mouse, rat TOX2
      QuantiFast Probe-based Assays in human, mouse, rat TOX2

    Additional mRNA sequence: 

    AK055135.1 AK124170.1 AK289906.1 AK298976.1 BC007636.1 

    10 DOTS entries:

    DT.210295  DT.100755183  DT.100657810  DT.97763625  DT.102822396  DT.92009933  DT.120831484  DT.120831503 
    DT.91999122  DT.120831507 

    Selected AceView cDNA sequences (see all 51):

    AA932528 NM_032883 AW614703 AA935506 BC007636 BQ051968 AI937226 AW665482 
    CR604013 AA781344 AW235616 BE327263 BQ051529 CB989964 AA209266 BG284712 
    AK055135 BQ217970 AI418459 BE296613 BQ927635 BF447680 BM673808 AI806024 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TOX2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12
    SP1:                                      -                                                     -                     
    SP2:                                      -                                                                           
    SP3:              -                       -                                                                           
    SP4:        -     -                       -                                                                           
    SP5:                                                                                      -     -     -               


    ECgene alternative splicing isoforms for TOX2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TOX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTCATCTA
    TOX2 Expression
    About this image


    TOX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Ventral/hypothalamic-like neurons
     
     Endothelium (Cardiovascular System)
             Endothelial-like cells
     
     Neurons
             Ventral/hypothalamic-like neurons
     
     Testis (Reproductive System)
    TOX2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TOX2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.26608
        Custom PCR Arrays for TOX2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TOX2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TOX2
    QuantiTect SYBR Green Assays in human, mouse, rat TOX2
    QuantiFast Probe-based Assays in human, mouse, rat TOX2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TOX2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tox21 , 5 TOX high mobility group box family member 21, 5 88.29(n)1
    91.81(a)1
      2 (84.14 cM)5
    2693891  NM_001098799.11  NP_001092269.11 
     1632031255 
    chicken
    (Gallus gallus)
    Aves TOX21 TOX high mobility group box family member 2 75.8(n)
    74.6(a)
      419156  XM_417340.4  XP_417340.3 
    lizard
    (Anolis carolinensis)
    Reptilia TOX26
    TOX high mobility group box family member 2
    66(a)
    1 ↔ 1
    4(135897782-136167817)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tox21 TOX high mobility group box family member 2 70.41(n)
    68.67(a)
      100124824  XM_004918519.1  XP_004918576.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tox21 TOX high mobility group box family member 2 67.67(n)
    63.29(a)
      405844  NM_212908.1  NP_998073.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes POB36
    Subunit of the heterodimeric FACT complex (Spt16p-...
    5(a)
    1 → many
    XIII(135500-137158) YML069W


    ENSEMBL Gene Tree for TOX2 (if available)
    TreeFam Gene Tree for TOX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TOX2 gene
    TOX2  TOX42  SSRP12  TOX32  
    3 SIMAP similar genes for TOX2 using alignment to 2 protein entries:     TOX2_HUMAN (see all proteins):
    Bbtx1    TOX    TOX3

    Find genes that share paralogs with TOX2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TOX2 (see all 3638)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs48127611,2
    C,F,A,H--42541539(+) AAAAAC/TACCCG 1 -- us2k119Minor allele frequency- T:0.28NS EA NA CSA WA 2344
    rs60312201,2
    C,F--42541760(+) GTTTGT/CGTGTA 1 -- us2k14Minor allele frequency- C:0.18NA WA 124
    rs1512639611,2
    --42541858(+) GGTAGA/GCTTAT 1 -- us2k10--------
    rs1847768251,2
    --42541888(+) TATAAA/GCCCAC 1 -- us2k10--------
    rs1405072311,2
    --42541939(+) ATAGGC/TTAACA 1 -- us2k10--------
    rs1119097601,2
    C--42542026(+) GAGTATG/-TGTGT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1999310841,2
    --42542045(+) AGGGG-/GGTGGTGG 1 -- us2k10--------
    rs1504363291,2
    C--42542225(+) TTTCCA/CTCTGT 1 -- us2k10--------
    rs1453313161,2
    --42542241(+) CCAAGC/TCTTCA 1 -- us2k10--------
    rs1492023161,2
    --42542246(+) CCTTCA/GGTGAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TOX2 (42543492 - 42698256 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TOX2 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv5288CNV Deletion18987735
    esv2487128CNV Deletion19546169
    esv2722440CNV Deletion23290073
    esv1996686CNV Deletion18987734
    esv2666708CNV Deletion23128226
    esv1002187CNV Deletion20482838
    esv1734532CNV Deletion17803354
    nsv509770CNV Insertion20534489
    esv1140542CNV Insertion17803354
    esv1000157CNV Insertion20482838

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TOX2
    DNA2.0 Custom Variant and Variant Library Synthesis for TOX2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611163    OMIM disorders: --


    Find genes that share disorders with TOX2           About GenesLikeMe

    Genetic Association Database (GAD): TOX2
    Human Genome Epidemiology (HuGE) Navigator: TOX2 (2 documents)

    Export disorders for TOX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TOX2 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with TOX2)
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    world of online information

    1. Genome-wide association study of conduct disorder symptomatology. (PubMed id 20585324)1, 4 Dick D.M....Bierut L. (Mol. Psychiatry 2011)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Cloning and characterization of granulosa cell high-mobility group (HMG)-box protein-1, a novel HMG-box transcriptional regulator strongly expressed in rat ovarian granulosa cells. (PubMed id 14764631)1, 3 Kajitani T....Miyamoto K. (Endocrinology 2004)
    7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Differential Epigenetic Regulation of TOX Subfamily High Mobility Group Box Genes in Lung and Breast Cancers. (PubMed id 22496870)1 Tessema M.... Belinsky S.A. (PLoS ONE 2012)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84969 HGNC: 16095 AceView: C20orf100 Ensembl:ENSG00000124191 euGenes: HUgn84969
    ECgene: TOX2 H-InvDB: TOX2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TOX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TOX2 gene:
    Search GeneIP for patents involving TOX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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