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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TOX2 Gene

protein-coding GIFtS: 46
GCID: GC20P042543

TOX high mobility group box family member 2

(Previous name: chromosome 20 open reading frame 100 )
(Previous symbol: C20orf100)

Explore 3 diseases affiliated with
TOX2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
TOX High Mobility Group Box Family Member 2¹ ²		DJ495O3.1¹
C20orf100¹ ² ³		Granulosa Cell HMG Box 1²
GCX-1¹ ² ³		GCX1³
DJ1108D11.2¹		Granulosa Cell HMG Box Protein 1³
Chromosome 20 Open Reading Frame 100¹

External Ids:	HGNC: 16095¹	Entrez Gene: 84969²	Ensembl: ENSG00000124191⁷	OMIM: 611163⁵	UniProtKB: Q96NM4³

Export aliases for TOX2 gene to outside databases

Previous GC identifers: GC20P041978 GC20P039278

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TOX2_HUMAN, Q96NM4

Function: Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011362.10

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TOX2 gene promoter:
GATA-3 COMP1 Nkx2-5 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TOX2 promoter sequence

Search SABiosciences Chromatin IP Primers for TOX2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOX2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q13.12

TOX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOX2 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P042543: view genomic region (about GC identifiers)

Start:	42,543,492 bp from pter	End:	42,698,256 bp from pter
Size:	154,765 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TOX2_HUMAN, Q96NM4 (See protein sequence)

Recommended Name: TOX high mobility group box family member 2

Size: 488 amino acids; 51604 Da

Subcellular location: Nucleus (By similarity)

Caution: It is uncertain whether Met-1 or Met-52 is the initiator

Secondary accessions: A8K1J1 E1P5X0 Q5TE33 Q5TE34 Q5TE35 Q96IC9 Q9BQN5

Alternative splicing: 3 isoforms: Q96NM4-1 Q96NM4-2 Q96NM4-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TOX2: NX_Q96NM4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96NM4

TOX2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001092266.1 NP_001092267.1 NP_001092268.1 NP_116272.1

ENSEMBL proteins:

ENSP00000396584 ENSP00000362090 ENSP00000350849 ENSP00000390876 ENSP00000344724

ENSP00000390278 ENSP00000396777

Human Recombinant Protein Products:

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	OriGene Purified Protein: TOX2 OriGene Protein Over-expression Lysate (see all 3): TOX2 OriGene Custom Protein Services for TOX2
	GenScript Custom Purified and Recombinant Proteins Services for TOX2
	Novus Biologicals TOX2 Protein Novus Biologicals TOX2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TOX2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

TOX2 for ontologies About GeneDecksing

TOX2 Antibody Products:

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	Novus Biologicals TOX2 Antibodies
	Search for Antibodies for TOX2 at Abcam
	Uscn Antibodies for TOX2
	Search ThermoFisher Antibodies for TOX2

Assay Products for TOX2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TOX2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TOX2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TOX2 for domains About GeneDecksing

1 InterPro domain/family:

IPR009071 HMG_superfamily

Graphical View of Domain Structure for InterPro Entry Q96NM4

ProtoNet protein and cluster: Q96NM4

UniProtKB/Swiss-Prot: TOX2_HUMAN, Q96NM4

Similarity: Contains 1 HMG box DNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TOX2_HUMAN, Q96NM4

Function: Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system

miRNA Products:		OriGene 3'-UTR Clone (see all 4): TOX2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TOX2
		8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate TOX2 (see all 20):
		hsa-miR-142-5p hsa-miR-4291 hsa-miR-4254 hsa-miR-185* hsa-miR-657 hsa-miR-1271 hsa-miR-340 hsa-miR-606

		SwitchGear 3'UTR luciferase reporter plasmid: TOX2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TOX2 (see all 7) OriGene shRNA RFP: TOX2 OriGene siRNA: TOX2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOX2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TOX2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOX2 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOX2 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TOX2 (NM_020225)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOX2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TOX2
		Search LifeMap BioReagents cell lines for TOX2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOX2

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0016563	transcription activator activity	--	--

TOX2 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TOX2

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for TOX2 (ENSP00000344724⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ZNF461	ENSP00000353515⁴	STRING: ENSP00000353515
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	--	--

TOX2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TOX2
Search CenterWatch for drugs/clinical trials and news about TOX2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TOX2 gene (4 alternative transcripts):

NM_001098796.1 NM_001098797.1 NM_001098798.1 NM_032883.2

Unigene Cluster for TOX2:

TOX high mobility group box family member 2

Hs.26608 [show with all ESTs]

Unigene Representative Sequence: AK055135

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000442881 ENST00000372999(uc002xle.4) ENST00000358131(uc002xlf.4)

ENST00000413823 ENST00000341197(uc010ggo.3) ENST00000423191(uc010ggp.3)

ENST00000435864(uc010zwk.2)

miRNA Products:		OriGene 3'-UTR Clone (see all 4): TOX2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TOX2
		8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate TOX2 (see all 20):
		hsa-miR-142-5p hsa-miR-4291 hsa-miR-4254 hsa-miR-185* hsa-miR-657 hsa-miR-1271 hsa-miR-340 hsa-miR-606

		SwitchGear 3'UTR luciferase reporter plasmid: TOX2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TOX2 (see all 7) OriGene shRNA RFP: TOX2 OriGene siRNA: TOX2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOX2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOX2 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOX2 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TOX2 (NM_020225)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOX2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOX2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOX2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TOX2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOX2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOX2

Additional cDNA sequence:

AK055135.1 AK124170.1 AK289906.1 AK298976.1 BC007636.1

10 DOTS entries:

DT.210295 DT.100755183 DT.100657810 DT.97763625 DT.102822396 DT.92009933 DT.120831484 DT.120831503

DT.91999122 DT.120831507

24/51 AceView cDNA sequences (see all 51):

AI937226 CR604013 BQ051968 AA781344 BC007636 AA935506 AW665482 AW235616

CB989964 BQ051529 BE327263 AW614703 NM_032883 AA932528 AA209266 BI820084

BQ786949 BM712530 BQ217970 BG284712 BQ927635 BF447680 AI806024 BE296613

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TOX2 (see all 7) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	·	6d	^	7	^	8a	·	8b	^	9a	·	9b	^	10	^	11	^	12
SP1:													-																		-
SP2:													-
SP3:					-								-
SP4:			-		-								-
SP5:																													-		-		-

ECgene alternative splicing isoforms for TOX2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TOX2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTCATCTA

About this image

TOX2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

N2/LSB/S/F8-induced cells (Generation of midbra...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TOX2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TOX2

SOURCE GeneReport for Unigene cluster: Hs.26608

SABiosciences Custom PCR Arrays for TOX2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOX2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOX2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOX2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOX2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TOX2 gene from 7/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TOX2¹	TOX high mobility group box family member 2	76.53(n) 75.2(a)		419156 XM_417340.3 XP_417340.3
lizard (Anolis carolinensis)	Reptilia	TOX2⁶	--	66(a)	1 ↔ 1	4(136119122-136157653)
zebrafish (Danio rerio)	Actinopterygii	tox2¹	TOX high mobility group box family member 2	70.05(n) 66.03(a)		405844 NM_212908.1 NP_998073.1
fruit fly (Drosophila melanogaster)	Insecta	CG12104⁶	--	18(a)	1 → many	3L(1600726-1602674)
worm (Caenorhabditis elegans)	Secernentea	hmg-1.2⁶	High mobility group protein 1.2	14(a)	possible ortholog	III(6280332-6283068)
thale cress (Arabidopsis thaliana)	eudicotyledons	NFD⁶	FACT complex subunit SSRP1	5(a)	possible ortholog	3(10784889-10788729)
rice (Oryza sativa)	Liliopsida	-- --	SSRP1-like FACT complex subunit, putative, express... SSRP1-like FACT complex subunit, putative, express...	5(a) 5(a)	possible ortholog possible ortholog	5(4965403-4971007) 1(4496719-4503407)

ENSEMBL Gene Tree for TOX2 (if available)
TreeFam Gene Tree for TOX2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TOX2 gene

TOX² TOX4² TOX3² HMGB4² HMGB3² HMGB1² HMGB2²

6 SIMAP similar genes for TOX2 using alignment to 4 protein entries: TOX2_HUMAN (see all proteins):

HMGB4 Bbtx1 TOX SMARCE1 TOX3 TOX4

TOX2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4812761^1,2	C,F,A,H,	--	42541539(+)	`AAAAAC/TACCCG`	1	--	us2k¹		19		NS EA NA CSA WA	2344
rs6031220^1,2	C,	--	42541760(+)	`GTTTGT/CGTGTA`	1	--	us2k¹		4		NA WA	124
rs151263961^1,2		--	42541858(+)	`GGTAGA/GCTTAT`	1	--	us2k¹		0	--	--	--	--
rs184776825^1,2		--	42541888(+)	`TATAAA/GCCCAC`	1	--	us2k¹		0	--	--	--	--
rs140507231^1,2		--	42541939(+)	`ATAGGC/TTAACA`	1	--	us2k¹		0	--	--	--	--
rs111909760^1,2	C,	--	42542026(+)	`GAGTATG/-TGTGT`	1	--	us2k¹		1		CSA	2
rs199931084^1,2		--	42542045(+)	`AGGGG-/GGTGGTGG`	1	--	us2k¹		0	--	--	--	--
rs150436329^1,2		--	42542225(+)	`TTTCCA/CTCTGT`	1	--	us2k¹		0	--	--	--	--
rs145331316^1,2		--	42542241(+)	`CCAAGC/TCTTCA`	1	--	us2k¹		0	--	--	--	--
rs149202316^1,2		--	42542246(+)	`CCTTCA/GGTGAA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TOX2 (42543492 - 42698256 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for TOX2
2 CNVs: 102977 23626
7 Indels: 12188 40456 42614 26829 46101 12189 61932

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOX2

DNA2.0 Custom Variant and Variant Library Synthesis for TOX2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TOX2 for disorders           About GeneDecksing

OMIM gene information: 611163    OMIM disorders: --

3 diseases for TOX2:    About MalaCards

conduct disorder malaria breast cancer

Human Genome Epidemiology (HuGE) Navigator: TOX2 (2 documents)

Export disorders for TOX2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TOX2 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with TOX2)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Cloning and characterization of granulosa cell high-mobility group (HMG)-box protein-1, a novel HMG-box transcriptional regulator strongly expressed in rat ovarian granulosa cells. (PubMed id 14764631)^{1, 3} Kajitani T....Miyamoto K. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
Differential Epigenetic Regulation of TOX Subfamily High Mobility Group Box Genes in Lung and Breast Cancers. (PubMed id 22496870)¹ Tessema M.... Belinsky S.A. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Genome-wide association study of conduct disorder sym ptomatology. (PubMed id 20585324)¹ Dick D.M....Bierut L. (2010)
Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)¹ Trynka G....Wijmenga C. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84969	HGNC: 16095	AceView: C20orf100	Ensembl:ENSG00000124191	euGenes: HUgn84969
ECgene: TOX2	H-InvDB: TOX2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TOX2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TOX2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TOX2 gene:
Search GeneIP for patents involving TOX2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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TOX2 Gene

TOX high mobility group box family member 2

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TOX2 Gene

TOX high mobility group box family member 2

Aliasesfor TOX2 gene

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Genomic Viewsfor TOX2 gene

Proteinsfor TOX2 gene

Protein Domains /Familiesfor TOX2 gene

Functionfor TOX2 gene

Pathways & Interactionsfor TOX2 gene

Drugs & Compoundsfor TOX2 gene

Transcriptsfor TOX2 gene

Expression for TOX2 gene

Orthologsfor TOX2 gene

Paralogsfor TOX2 gene

Genomic Variantsfor TOX2 gene

Disorders / Diseasesfor TOX2 gene

Publicationsfor TOX2 gene

External Searches for TOX2 gene

Genome Databases showing TOX2 gene

Other Databases showing TOX2 gene

Specialized Databases showing TOX2 gene

Intellectual Propertyfor TOX2 gene

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Aliases
for TOX2 gene

Summaries
for TOX2 gene

Genomic Views
for TOX2 gene

Proteins
for TOX2 gene

Protein Domains /
Families
for TOX2 gene

Function
for TOX2 gene

Pathways & Interactions
for TOX2 gene

Drugs & Compounds
for TOX2 gene

Transcripts
for TOX2 gene

Expression
for TOX2 gene

Orthologs
for TOX2 gene

Paralogs
for TOX2 gene

Genomic Variants
for TOX2 gene

Disorders / Diseases
for TOX2 gene

Publications
for TOX2 gene

Intellectual Property
for TOX2 gene

Products
for TOX2 gene