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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TOX Gene

protein-coding   GIFtS: 49
GCID: GC08M059717

thymocyte selection-associated high mobility group box
 Explore 9 diseases affiliated with
TOX via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TOX    

Aliases
for TOX gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Thymocyte Selection-Associated High Mobility Group Box1 2
KIAA08081 3 5
TOX11 2
Thymus High Mobility Group Box Protein TOX2 3
Thymocyte Selection-Associated High Mobility Group Box Protein TOX2

External Ids:    HGNC: 189881   Entrez Gene: 97602   Ensembl: ENSG000001988467   OMIM: 6068635   UniProtKB: O949003   

Export aliases for TOX gene to outside databases

Previous GC identifers: GC08M058791 GC08M059657 GC08M059441 GC08M059767 GC08M059880 GC08M055205


Summaries
for TOX gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TOX:
The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins
involved in chromatin assembly, transcription and replication. This protein may function to regulate T-cell
development.(provided by RefSeq, Apr 2009)

UniProtKB/Swiss-Prot: TOX_HUMAN, O94900
Function: May play a role in regulating T-cell development (By similarity)

Gene Wiki entry for TOX


Genomic Views
for TOX gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TOX gene promoter:
         GATA-3   Pax-5   GATA-2   GATA-1   NF-AT   NF-AT4   NF-AT2   NF-AT3   Pax-4a   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TOX promoter sequence
   Search SABiosciences Chromatin IP Primers for TOX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q12.1   Ensembl cytogenetic band:  8q12.1   HGNC cytogenetic band: 8q12.2-q12.3

TOX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOX gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M059717:  view genomic region     (about GC identifiers)

Start:
 59,717,977 bp from pter      End:
 60,031,767 bp from pter
Size:
 313,791 bases      Orientation:
 minus strand

Proteins
for TOX gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TOX_HUMAN, O94900 (See protein sequence)
Recommended Name: Thymocyte selection-associated high mobility group box protein TOX  
Size: 526 amino acids; 57513 Da
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAA34528.2; Type=Erroneous initiation;
Secondary accessions: Q96AV5

Explore the universe of human proteins at neXtProt for TOX: NX_O94900

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O94900

    • TOX Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055544.1  
    ENSEMBL proteins: 
     ENSP00000354842  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: TOX
    OriGene Protein Over-expression Lysate: TOX
    OriGene Custom Protein Services for TOX 
    GenScript Custom Purified and Recombinant Proteins Services for TOX
    Novus Biologicals TOX Protein
    Novus Biologicals TOX Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TOX

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    TOX for ontologies           About GeneDecksing



    TOX Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TOX 
    GenScript Superior Antibodies for TOX
    Novus Biologicals TOX Antibodies
    Search for Antibodies for TOX at Abcam  
    Uscn Antibodies for TOX
    Search ThermoFisher Antibodies for TOX

    Assay Products for TOX: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TOX
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TOX

    Protein Domains /
    Families
    for TOX gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TOX for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR009071 HMG_superfamily

    Graphical View of Domain Structure for InterPro Entry O94900

    ProtoNet protein and cluster: O94900

    UniProtKB/Swiss-Prot: TOX_HUMAN, O94900
    Similarity: Contains 1 HMG box DNA-binding domain


    Function
    for TOX gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TOX_HUMAN, O94900
    Function: May play a role in regulating T-cell development (By similarity)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: TOX
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TOX
    8/107 QIAGEN miScript miRNA Assays for microRNAs that regulate TOX (see all 107):
    hsa-miR-3607-3p hsa-miR-520e hsa-miR-520f hsa-miR-30d hsa-miR-759 hsa-miR-519a hsa-miR-30a hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmid: TOX 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TOX (see all 7)
    OriGene shRNA RFP: TOX
    OriGene siRNA: TOX
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOX

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TOX

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOX (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOX
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TOX (NM_004045)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOX 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TOX
    Search LifeMap BioReagents cell lines for TOX

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOX

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--


    TOX for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Toxtm1.1Kay for TOX
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Tox):
     cellular  digestive/alimentary  hematopoietic system  immune system 

    TOX for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TOX gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TOX

    Drugs & Compounds
    for TOX gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TOX
    Search CenterWatch for drugs/clinical trials and news about TOX 

    Transcripts
    for TOX gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TOX gene: 
    NM_014729.2  

    Unigene Cluster for TOX:

    Thymocyte selection-associated high mobility group box
    Hs.491805  [show with all ESTs]
    Unigene Representative Sequence: BX647462
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000361421(uc003xtw.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: TOX
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TOX
    8/107 QIAGEN miScript miRNA Assays for microRNAs that regulate TOX (see all 107):
    hsa-miR-3607-3p hsa-miR-520e hsa-miR-520f hsa-miR-30d hsa-miR-759 hsa-miR-519a hsa-miR-30a hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmid: TOX 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TOX (see all 7)
    OriGene shRNA RFP: TOX
    OriGene siRNA: TOX
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOX
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOX (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOX
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TOX (NM_004045)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOX 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOX
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TOX
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOX
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOX

    Additional cDNA sequence: 

    AB018351.1 AK000971.1 AK302331.1 BC016665.1 BX647462.1 

    4 DOTS entries:

    DT.440697  DT.100708490  DT.121489305  DT.97808970 

    24/114 AceView cDNA sequences (see all 114):

    CK819996 BI761311 AA947946 F03243 AB018351 BM930785 AW172879 AA906617 
    AA687397 AA877084 Z44018 BM353988 R44946 AI961231 BM684634 BQ478444 
    BQ774581 AU117984 BX108481 BE220326 T27108 Z43888 BM142206 AL558853 

    GeneLoc Exon Structure


    Expression
    for TOX gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TOX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATAAAGCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TOX expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeRetinaEye
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)
    ES04(HES-4) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Matrigel embedded cells (Derivation of cardio...)

    See TOX Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TOX

    SOURCE GeneReport for Unigene cluster: Hs.491805
        SABiosciences Expression via Pathway-Focused PCR Array including TOX: 
              T Helper Cell Differentiation in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOX
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TOX
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOX
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOX
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOX

    Orthologs
    for TOX gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TOX gene from 8/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TOX1 thymocyte selection-associated high mobility group more 85.86(n)
    92.64(a)    		   421138  NM_001031025.1  NP_001026196.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TOX6
    		 --
    		 90(a)
    		 1 ↔ 1
    		 4(27747657-27852697)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.14572 Xenopus laevis transcribed sequences 83.81(n)    BX844585.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii tox1 thymocyte selection-associated high mobility group more 68.06(n)
    67.27(a)    		   569666  XM_001919504.3  XP_001919539.3 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG121046
    		 --
    		 18(a)
    		 1 → many
    		 3L(1600726-1602674)
    worm
    (Caenorhabditis elegans)    		 Secernentea hmg-1.26
    		 High mobility group protein 1.2
    		 12(a)
    		 possible ortholog
    		 III(6280332-6283068)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons NFD6
    		 FACT complex subunit SSRP1
    		 4(a)
    		 possible ortholog
    		 3(10784889-10788729)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 SSRP1-like FACT complex subunit, putative, express...
    SSRP1-like FACT complex subunit, putative, express...
    		 5(a)
    5(a)
    		 possible ortholog
    possible ortholog
    		 5(4965403-4971007)
    1(4496719-4503407)


    ENSEMBL Gene Tree for TOX (if available)
    TreeFam Gene Tree for TOX (if available) 

    Paralogs
    for TOX gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TOX gene
    TOX42  TOX32  HMGB42  HMGB32  HMGB12  TOX22  HMGB22  
    4 SIMAP similar genes for TOX using alignment to 1 protein entry:     TOX_HUMAN:
    Bbtx1    TOX3    TOX2    TOX4

    TOX for paralogs           About GeneDecksing



    Genomic Variants
    for TOX gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5029 NCBI SNPs in TOX are shown (see all 5029)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1120670611,2
    		--55204979(+) CTGTCG/ATTCCA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs760715291,2
    		--55205089(+) CAGCTA/CCAAGC 1 -- ds50010--------
    rs778891601,2
    		--55205136(+) TGGCTT/CTCTGA 1 -- ds50012Minor allele frequency- C:0.05CSA WA 120
    rs169239911,2
    		C,F,--55205216(+) GTTTCA/GGGAAA 1 -- ds50013Minor allele frequency- G:0.01NA 140
    rs757798491,2
    		F,--55205244(+) GCGGCC/GATTAA 1 -- ds50011Minor allele frequency- G:0.02NA 120
    rs625051141,2
    		--55205359(+) ACGCAT/CAATAA 1 -- ut312Minor allele frequency- C:0.04NA 122
    rs599094921,2
    		C,--55205902(+) ACTGCC/TAAATT 1 -- ut311Minor allele frequency- T:0.50WA 2
    rs769025461,2
    		F,--55205995(+) AAGGAG/CTAAAT 1 -- ut311Minor allele frequency- C:0.04WA 118
    rs585892081,2
    		--55206186(+) AACAGC/GTTTCA 1 -- ut310--------
    rs736846631,2
    		C,--55206348(+) CTTTTT/ACTTTT 1 -- ut311Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for TOX (59717977 - 59967977 bp, first 250kb of TOX)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TOX: --
    Locus Specific Mutation Databases (LSDB): TOX

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOX
    DNA2.0 Custom Variant and Variant Library Synthesis for TOX

    Disorders / Diseases
    for TOX gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TOX for disorders           About GeneDecksing

    OMIM gene information: 606863    OMIM disorders: --

    9 diseases for TOX:    About MalaCards
    estrogen-receptor positive breast cancer    sickle cell anemia    toxic encephalopathy    diphtheria
    toxoplasmosis    diarrhea    breast cancer    anemia
    malaria

    3 diseases from the University of Copenhagen DISEASES database for TOX:
    Diphtheria     Diarrhea     Toxic encephalopathy
    Human Genome Epidemiology (HuGE) Navigator: TOX (6 documents)

    Export disorders for TOX gene to outside databases

    Publications
    for TOX gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TOX gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with TOX)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. TOX: an HMG box protein implicated in the regulation of thymocyte selection. (PubMed id 11850626)1, 3 Wilkinson B....Kaye J. (2002)
    4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    5. TOX provides a link between calcineurin activation and CD8 lineage commitment. (PubMed id 15078895)1, 9 Aliahmad P....Kaye J. (2004)
    6. Differential Epigenetic Regulation of TOX Subfamily High Mobility Group Box Genes in Lung and Breast Cancers. (PubMed id 22496870)1 Tessema M.... Belinsky S.A. (2012)
    7. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    8. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (2011)
    9. TOX regulates the differentiation of human natural ki ller cells from hematopoietic stem cells in vitro. (PubMed id 21126536)1 Yun S....Choi I. (2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    External Searches for TOX gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
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    OMIM
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    Genome Databases showing TOX gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9760 HGNC: 18988 AceView: TOX Ensembl:ENSG00000198846 euGenes: HUgn9760
    ECgene: TOX H-InvDB: TOX

    Other Databases showing TOX gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0808

    Specialized Databases showing TOX gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TOX Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TOX gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TOX gene:
    Search GeneIP for patents involving TOX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TOX gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
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     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for TOX  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TOX   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOX  
     OriGene Protein Over-expression Lysate for TOX   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TOX   OriGene 3'-UTR Clone for TOX  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOX   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOX  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for TOX   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TOX   OriGene Custom Protein Services for TOX  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TOX
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOX
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOX
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOX
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     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOX
     GenScript Custom Purified and Recombinant Proteins Services for TOX GenScript cDNA clones with any tag delivered in your preferred vector for TOX
     GenScript Custom Assay Services for TOX GenScript Superior Antibodies for TOX
     GenScript Custom overexpressing Cell Line Services for TOX CloneReady with Over 120,000 Genes
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     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TOX promoter
     Search Chromatin IP Primers for TOX
     RT2 qPCR Primer Assay in human, mouse, rat TOX
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     SABiosciences PCR Arrays including human, mouse, rat TOX
     Search Tocris compounds for TOX
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TOX antibodies
     TOX proteins
     TOX lysates
     Search for Antibodies for TOX at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TOX
     Custom Antibody / Protein Production Service
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     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     TOX Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for TOX
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOX
     SwitchGear 3'UTR luciferase reporter plasmids for TOX
     SwitchGear Promoter luciferase reporter plasmids for TOX
     Search ThermoFisher Antibodies for TOX
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOX
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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