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Aliases for TOX Gene

Aliases for TOX Gene

  • Thymocyte Selection Associated High Mobility Group Box 2 3 5
  • Thymus High Mobility Group Box Protein TOX 3 4
  • KIAA0808 4
  • TOX1 3

External Ids for TOX Gene

Previous GeneCards Identifiers for TOX Gene

  • GC08M059657
  • GC08M059441
  • GC08M059767
  • GC08M059880
  • GC08M059717
  • GC08M055205

Summaries for TOX Gene

Entrez Gene Summary for TOX Gene

  • The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. This protein may function to regulate T-cell development.[provided by RefSeq, Apr 2009]

GeneCards Summary for TOX Gene

TOX (Thymocyte Selection Associated High Mobility Group Box) is a Protein Coding gene. Diseases associated with TOX include Cutaneous Diphtheria and Astigmatism. GO annotations related to this gene include chromatin binding. An important paralog of this gene is TOX4.

UniProtKB/Swiss-Prot for TOX Gene

  • May play a role in regulating T-cell development.

Gene Wiki entry for TOX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOX Gene

Genomics for TOX Gene

Regulatory Elements for TOX Gene

Enhancers for TOX Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TOX on UCSC Golden Path with GeneCards custom track

Promoters for TOX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TOX on UCSC Golden Path with GeneCards custom track

Genomic Location for TOX Gene

Chromosome:
8
Start:
58,805,418 bp from pter
End:
59,119,208 bp from pter
Size:
313,791 bases
Orientation:
Minus strand

Genomic View for TOX Gene

Genes around TOX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOX Gene

Proteins for TOX Gene

  • Protein details for TOX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94900-TOX_HUMAN
    Recommended name:
    Thymocyte selection-associated high mobility group box protein TOX
    Protein Accession:
    O94900
    Secondary Accessions:
    • Q96AV5

    Protein attributes for TOX Gene

    Size:
    526 amino acids
    Molecular mass:
    57513 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA34528.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TOX Gene

Proteomics data for TOX Gene at MOPED

Post-translational modifications for TOX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TOX Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for TOX1

No data available for DME Specific Peptides for TOX Gene

Domains & Families for TOX Gene

Protein Domains for TOX Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TOX Gene

Graphical View of Domain Structure for InterPro Entry

O94900

UniProtKB/Swiss-Prot:

TOX_HUMAN :
  • Contains 1 HMG box DNA-binding domain.
Domain:
  • Contains 1 HMG box DNA-binding domain.
genes like me logo Genes that share domains with TOX: view

No data available for Gene Families for TOX Gene

Function for TOX Gene

Molecular function for TOX Gene

UniProtKB/Swiss-Prot Function:
May play a role in regulating T-cell development.
genes like me logo Genes that share phenotypes with TOX: view

Animal Models for TOX Gene

MGI Knock Outs for TOX:

Animal Model Products

miRNA for TOX Gene

miRTarBase miRNAs that target TOX

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TOX Gene

Localization for TOX Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOX Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TOX Gene COMPARTMENTS Subcellular localization image for TOX gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1
extracellular 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for TOX Gene

Pathways & Interactions for TOX Gene

SuperPathways for TOX Gene

No Data Available

Gene Ontology (GO) - Biological Process for TOX Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TOX Gene

Drugs & Compounds for TOX Gene

No Compound Related Data Available

Transcripts for TOX Gene

mRNA/cDNA for TOX Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(114) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TOX Gene

Thymocyte selection-associated high mobility group box:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TOX Gene

No ASD Table

Relevant External Links for TOX Gene

GeneLoc Exon Structure for
TOX
ECgene alternative splicing isoforms for
TOX

Expression for TOX Gene

mRNA expression in normal human tissues for TOX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TOX Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.1).

Protein differential expression in normal tissues from HIPED for TOX Gene

This gene is overexpressed in CD8 Tcells (57.3) and Testis (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TOX Gene



SOURCE GeneReport for Unigene cluster for TOX Gene Hs.491805

genes like me logo Genes that share expression patterns with TOX: view

Protein tissue co-expression partners for TOX Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TOX Gene

Orthologs for TOX Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TOX Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TOX 35
  • 91.38 (n)
  • 95.63 (a)
TOX 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TOX 35
  • 93.85 (n)
  • 97.34 (a)
TOX 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tox 35
  • 89.16 (n)
  • 94.3 (a)
Tox 16
Tox 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TOX 35
  • 99.81 (n)
  • 100 (a)
TOX 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tox 35
  • 89.65 (n)
  • 94.67 (a)
oppossum
(Monodelphis domestica)
Mammalia TOX 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TOX 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves TOX 35
  • 85.86 (n)
  • 92.64 (a)
TOX 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TOX 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tox 35
  • 78.65 (n)
  • 84.13 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1457 35
zebrafish
(Danio rerio)
Actinopterygii tox 35
  • 67.73 (n)
  • 67.07 (a)
tox 36
  • 62 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POB3 36
  • 6 (a)
OneToMany
Species with no ortholog for TOX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TOX Gene

ENSEMBL:
Gene Tree for TOX (if available)
TreeFam:
Gene Tree for TOX (if available)

Paralogs for TOX Gene

Paralogs for TOX Gene

(3) SIMAP similar genes for TOX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TOX: view

Variants for TOX Gene

Sequence variations from dbSNP and Humsavar for TOX Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_064759 -
rs2044643 -- 58,897,749(-) TCAAC(A/C)ACAAT intron-variant
rs2059836 -- 59,038,339(+) ACTAG(A/T)AAGGC intron-variant
rs2115147 -- 59,039,377(+) TATTG(C/T)TACAC intron-variant
rs2122015 -- 58,860,945(-) TATAC(C/G)CCATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TOX Gene

Variant ID Type Subtype PubMed ID
nsv890938 CNV Gain 21882294
nsv6213 CNV Insertion 18451855
nsv890940 CNV Loss 21882294
esv2737046 CNV Deletion 23290073
nsv526468 CNV Loss 19592680
esv2737047 CNV Deletion 23290073
esv268010 CNV Insertion 20981092
nsv525018 CNV Loss 19592680
esv1732094 CNV Insertion 17803354
esv1476730 CNV Insertion 17803354
nsv831327 CNV Loss 17160897
nsv6214 CNV Insertion 18451855

Variation tolerance for TOX Gene

Residual Variation Intolerance Score: 76.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.50; 55.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TOX Gene

Human Gene Mutation Database (HGMD)
TOX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOX Gene

Disorders for TOX Gene

MalaCards: The human disease database

(4) MalaCards diseases for TOX Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cutaneous diphtheria
astigmatism
refractive error
  • refractive errors
congenital toxoplasmosis
  • toxoplasmosis - congen.
- elite association - COSMIC cancer census association via MalaCards
Search TOX in MalaCards View complete list of genes associated with diseases

Relevant External Links for TOX

Genetic Association Database (GAD)
TOX
Human Genome Epidemiology (HuGE) Navigator
TOX
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TOX
genes like me logo Genes that share disorders with TOX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TOX Gene

Publications for TOX Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. TOX provides a link between calcineurin activation and CD8 lineage commitment. (PMID: 15078895) Aliahmad P. … Kaye J. (J. Exp. Med. 2004) 3 23
  3. TOX: an HMG box protein implicated in the regulation of thymocyte selection. (PMID: 11850626) Wilkinson B. … Kaye J. (Nat. Immunol. 2002) 2 3
  4. Evidence of an oncogenic role of aberrant TOX activation in cutaneous T-cell lymphoma. (PMID: 25548321) Huang Y. … Zhou Y. (Blood 2015) 3
  5. Intracranial aneurysm risk factor genes: relationship with intracranial aneurysm risk in a Chinese Han population. (PMID: 26125895) Zhang L.T. … Yang X.Y. (Genet. Mol. Res. 2015) 3

Products for TOX Gene

Sources for TOX Gene

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