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TOX Gene

protein-coding   GIFtS: 55
GCID: GC08M059717

Thymocyte Selection-Associated High Mobility Group Box

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thymocyte Selection-Associated High Mobility Group Box1 2
Thymus High Mobility Group Box Protein TOX2 3
KIAA08083 5
TOX12
Thymocyte Selection-Associated High Mobility Group Box Protein TOX2

External Ids:    HGNC: 189881   Entrez Gene: 97602   Ensembl: ENSG000001988467   OMIM: 6068635   UniProtKB: O949003   

Export aliases for TOX gene to outside databases

Previous GC identifers: GC08M058791 GC08M059657 GC08M059441 GC08M059767 GC08M059880 GC08M055205


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TOX Gene:
The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic
proteins involved in chromatin assembly, transcription and replication. This protein may function to regulate
T-cell development.(provided by RefSeq, Apr 2009)

GeneCards Summary for TOX Gene:
TOX (thymocyte selection-associated high mobility group box) is a protein-coding gene. Diseases associated with TOX include estrogen-receptor positive breast cancer, and refractive error. An important paralog of this gene is TOX4.

UniProtKB/Swiss-Prot: TOX_HUMAN, O94900
Function: May play a role in regulating T-cell development (By similarity)

Gene Wiki entry for TOX Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008183.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the TOX gene promoter:
         GATA-3   Pax-5   GATA-2   GATA-1   NF-AT   NF-AT4   NF-AT2   NF-AT3   Pax-4a   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTOX promoter sequence
   Search Chromatin IP Primers for TOX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TOX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q12.1   Ensembl cytogenetic band:  8q12.1   HGNC cytogenetic band: 8q12.2-q12.3

TOX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOX gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M059717:  view genomic region     (about GC identifiers)

Start:
59,717,977 bp from pter      End:
60,031,767 bp from pter
Size:
313,791 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TOX_HUMAN, O94900 (See protein sequence)
Recommended Name: Thymocyte selection-associated high mobility group box protein TOX  
Size: 526 amino acids; 57513 Da
Sequence caution: Sequence=BAA34528.2; Type=Erroneous initiation;
Secondary accessions: Q96AV5

Explore the universe of human proteins at neXtProt for TOX: NX_O94900

Explore proteomics data for TOX at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TOX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055544.1  
    ENSEMBL proteins: 
     ENSP00000354842  

    TOX Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TOX
    OriGene Protein Over-expression Lysate for TOX
    OriGene MassSpec for TOX
    OriGene Custom Protein Services for TOX
    GenScript Custom Purified and Recombinant Proteins Services for TOX
    Novus Biologicals TOX Protein
    Novus Biologicals TOX Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TOX

    TOX Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TOX
    OriGene Custom Antibody Services for TOX
    Novus Biologicals TOX Antibodies
    Abcam antibodies for TOX
    Cloud-Clone Corp. Antibodies for TOX
    ThermoFisher Antibodies for TOX
    LSBio Antibodies in human, mouse, rat for TOX

    TOX Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TOX
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TOX
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TOX
    Cloud-Clone Corp. CLIAs for TOX


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009071 HMG_box_dom

    Graphical View of Domain Structure for InterPro Entry O94900

    ProtoNet protein and cluster: O94900

    UniProtKB/Swiss-Prot: TOX_HUMAN, O94900
    Similarity: Contains 1 HMG box DNA-binding domain


    TOX for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TOX_HUMAN, O94900
    Function: May play a role in regulating T-cell development (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
         
    TOX for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tox):
     digestive/alimentary  hematopoietic system  immune system 

    TOX for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Toxtm1.1Kay for TOX

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TOX
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TOX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TOX
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TOX

    miRNA
    Products:
        
    miRTarBase miRNAs that target TOX:
    hsa-mir-26b-5p (MIRT030248)

    Block miRNA regulation of human, mouse, rat TOX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TOX (see all 107):
    hsa-miR-3607-3p hsa-miR-520e hsa-miR-520f hsa-miR-30d hsa-miR-759 hsa-miR-519a hsa-miR-30a hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidTOX 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TOX
    Predesigned siRNA for gene silencing in human, mouse, rat TOX

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TOX

    Clone
    Products:
         
    OriGene clones in human, mouse for TOX (see all 6)
    OriGene ORF clones in mouse, rat for TOX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TOX (NM_004045)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOX

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TOX
    Browse ESI BIO Cell Lines and PureStem Progenitors for TOX 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TOX_HUMAN, O94900: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    TOX for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including TOX: 
              T Helper Cell Differentiation in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TOX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for TOX (ENSP000003548424) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UMPSENSP000002326074STRING: ENSP00000232607
    XRCC6ENSP000003522574STRING: ENSP00000352257
    ACTR5ENSP000002439034STRING: ENSP00000243903
    ACTR8ENSP000003368424STRING: ENSP00000336842
    RUVBL2ENSP000002214134STRING: ENSP00000221413
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TOX



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TOX gene: 
    NM_014729.2  

    Unigene Cluster for TOX:

    Thymocyte selection-associated high mobility group box
    Hs.491805  [show with all ESTs]
    Unigene Representative Sequence: BX647462
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000361421(uc003xtw.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TOX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TOX (see all 107):
    hsa-miR-3607-3p hsa-miR-520e hsa-miR-520f hsa-miR-30d hsa-miR-759 hsa-miR-519a hsa-miR-30a hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidTOX 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TOX
    Predesigned siRNA for gene silencing in human, mouse, rat TOX
    Clone
    Products:
         
    OriGene clones in human, mouse for TOX (see all 6)
    OriGene ORF clones in mouse, rat for TOX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TOX (NM_004045)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOX
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TOX
    OriGene qSTAR qPCR primer pairs in human, mouse for TOX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TOX
      QuantiTect SYBR Green Assays in human, mouse, rat TOX
      QuantiFast Probe-based Assays in human, mouse, rat TOX

    Additional mRNA sequence: 

    AB018351.1 AK000971.1 AK302331.1 BC016665.1 BX647462.1 

    4 DOTS entries:

    DT.440697  DT.100708490  DT.121489305  DT.97808970 

    Selected AceView cDNA sequences (see all 114):

    Z44018 CF138347 BM680682 AU117984 AA972336 AA947946 AA401275 AA906617 
    AA932410 BM930785 CD676088 BX108481 BM684634 AI961231 R44946 AB018351 
    NM_014729 AA832293 CK819996 BI761311 AW172879 BM142206 AI024394 Z43888 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TOX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAAGCCA
    TOX Expression
    About this image


    TOX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Blood (Cardiovascular System)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Eye (Sensory Organs)
             Retina
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
    TOX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TOX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.491805
        Pathway & Disease-focused RT2 Profiler PCR Array including TOX: 
              T Helper Cell Differentiation in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TOX
    OriGene qSTAR qPCR primer pairs in human, mouse for TOX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TOX
    QuantiTect SYBR Green Assays in human, mouse, rat TOX
    QuantiFast Probe-based Assays in human, mouse, rat TOX
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TOX gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tox1 , 5 thymocyte selection-associated high mobility group more1, 5 89.16(n)1
    94.3(a)1
      4 (3.04 cM)5
    2528381  NM_145711.41  NP_663757.31 
     66863535 
    chicken
    (Gallus gallus)
    Aves TOX1 thymocyte selection-associated high mobility group more 85.86(n)
    92.64(a)
      421138  NM_001031025.1  NP_001026196.1 
    lizard
    (Anolis carolinensis)
    Reptilia TOX6
    thymocyte selection-associated high mobility group...
    87(a)
    1 ↔ 1
    4(27744247-28011216)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.14572 Xenopus laevis transcribed sequences 83.81(n)    BX844585.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tox1 thymocyte selection-associated high mobility group more 67.73(n)
    67.07(a)
      569666  NM_001256694.1  NP_001243623.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes POB36
    Subunit of the heterodimeric FACT complex (Spt16p-...
    6(a)
    1 → many
    XIII(135500-137158) YML069W


    ENSEMBL Gene Tree for TOX (if available)
    TreeFam Gene Tree for TOX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TOX gene
    TOX42  SSRP12  TOX32  TOX22  
    3 SIMAP similar genes for TOX using alignment to 1 protein entry:     TOX_HUMAN:
    Bbtx1    TOX3    TOX2

    TOX for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TOX (see all 5856)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs345277271,2
    C--55232109(+) ATGTA-/ATATATA 1 -- int10--------
    rs1392723551,2
    --55238632(+) TCCTT-/GTCTTTTT 1 -- int10--------
    rs1998338471,2
    C--55238632(+) TCCTTG/TTCTTT 1 -- int10--------
    rs736867271,2
    C--55289160(+) AAAAAA/CAAAAA 1 -- int11Minor allele frequency- C:0.00WA 2
    rs1444765151,2
    C--55313734(+) AAAAG-/CTCTAA 1 -- int10--------
    rs1503990531,2
    C--55321820(+) TGATA-/AGCC  
            
    AGCCA
    1 -- int10--------
    rs345035471,2
    C--55348368(+) ATCTA-/TTTTTT 1 -- int10--------
    rs595651471,2
    C--55361390(+) AAGTG-/CTGGGA 1 -- int10--------
    rs340169061,2
    C--55374864(+) TATAT-/ACACACA 1 -- int10--------
    rs666420721,2
    C--55396908(+) ATTTA-/AG    
       C
    /CAG
    GAAAT
    2 -- cds10--------

    HapMap Linkage Disequilibrium report for TOX (59717977 - 59967977 bp, first 250kb of TOX)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TOX (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2737046CNV Deletion23290073
    esv2737047CNV Deletion23290073
    nsv6213CNV Insertion18451855
    esv1732094CNV Insertion17803354
    esv1476730CNV Insertion17803354
    esv268010CNV Insertion20981092
    nsv6214CNV Insertion18451855
    nsv831327CNV Loss17160897
    nsv526468CNV Loss19592680
    nsv525018CNV Loss19592680

    Human Gene Mutation Database (HGMD): TOX
    Locus Specific Mutation Databases (LSDB): TOX

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TOX
    DNA2.0 Custom Variant and Variant Library Synthesis for TOX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606863    OMIM disorders: --

    13 diseases for TOX:    
    About MalaCards
    estrogen-receptor positive breast cancer    refractive error    toxic encephalopathy    sickle cell anemia
    diphtheria    toxoplasmosis    pulmonary tuberculosis    myopia
    diarrhea    myocardial infarction    breast cancer    tuberculosis
    cervicitis

    3 diseases from the University of Copenhagen DISEASES database for TOX:
    Diphtheria     Diarrhea     Toxic encephalopathy

    TOX for disorders           About GeneDecksing

    Genetic Association Database (GAD): TOX
    Human Genome Epidemiology (HuGE) Navigator: TOX (6 documents)

    Export disorders for TOX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TOX gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with TOX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PubMed id 19734545)1, 4 Need A.C....Goldstein D.B. (Hum. Mol. Genet. 2009)
    4. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. ( a journal of cerebral circulation 2009)
    5. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008)
    6. Fetal hemoglobin in sickle cell anemia: Bayesian modeling of genetic associations. (PubMed id 17918249)1, 4 Sebastiani P....Steinberg M.H. (Am. J. Hematol. 2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. TOX: an HMG box protein implicated in the regulation of thymocyte selection. (PubMed id 11850626)1, 3 Wilkinson B....Kaye J. (Nat. Immunol. 2002)
    9. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    10. TOX provides a link between calcineurin activation and CD8 lineage commitment. (PubMed id 15078895)1, 9 Aliahmad P....Kaye J. (J. Exp. Med. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9760 HGNC: 18988 AceView: TOX Ensembl:ENSG00000198846 euGenes: HUgn9760
    ECgene: TOX H-InvDB: TOX

    (According to HUGE)
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    HUGE: KIAA0808

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TOX Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TOX gene:
    Search GeneIP for patents involving TOX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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