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Aliases for TOX Gene

Aliases for TOX Gene

  • Thymocyte Selection Associated High Mobility Group Box 2 3 5
  • Thymus High Mobility Group Box Protein TOX 3 4
  • Thymocyte Selection-Associated High Mobility Group Box Protein TOX 3
  • KIAA0808 4
  • TOX1 3

External Ids for TOX Gene

Previous GeneCards Identifiers for TOX Gene

  • GC08M059657
  • GC08M059441
  • GC08M059767
  • GC08M059880
  • GC08M059717
  • GC08M055205

Summaries for TOX Gene

Entrez Gene Summary for TOX Gene

  • The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. This protein may function to regulate T-cell development.[provided by RefSeq, Apr 2009]

GeneCards Summary for TOX Gene

TOX (Thymocyte Selection Associated High Mobility Group Box) is a Protein Coding gene. Diseases associated with TOX include Cutaneous Diphtheria and Clostridium Difficile Colitis. Among its related pathways are Mesodermal Commitment Pathway and Development and heterogeneity of the ILC family. GO annotations related to this gene include chromatin binding. An important paralog of this gene is TOX3.

UniProtKB/Swiss-Prot for TOX Gene

  • May play a role in regulating T-cell development.

Gene Wiki entry for TOX Gene

Additional gene information for TOX Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOX Gene

Genomics for TOX Gene

Regulatory Elements for TOX Gene

Enhancers for TOX Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H058799 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.3 +317.7 317730 3.6 PKNOX1 ATF1 GATA2 ATF7 RUNX3 JUNB STAT3 NBN HMBOX1 LEF1 TOX LOC100505501 RNU4-50P GC08M058815 LOC105375858
GH08H059147 1 ENCODE dbSUPER 18.8 -28.6 -28616 1 PKNOX1 TBL1XR1 BACH1 BMI1 BATF EED ATF7 ETV6 RUNX3 IKZF2 TOX LOC100505501 ENSG00000206853 GC08M059155 GC08M059138
GH08H058828 2.1 Ensembl ENCODE dbSUPER 8.4 +287.3 287309 5.8 PKNOX1 JUN USF2 FOSL1 JUND FOXK2 POLR2A IKZF1 FOXJ2 FOS TOX RNU4-50P GC08M058815 GC08P058884
GH08H059236 0.9 FANTOM5 ENCODE 16.6 -117.9 -117920 1.1 FOSL1 JUND ZNF316 MAFG FOS NFE2 EMSY TOX GC08P059295 GC08M059177
GH08H058855 1.9 VISTA FANTOM5 Ensembl ENCODE dbSUPER 7.8 +261.5 261496 4.6 PKNOX1 CBX5 RCOR1 RUNX3 CEBPB NFIC MAFF IKZF1 HMBOX1 NR2C1 TOX GC08P058884 GC08M058815 RNU4-50P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TOX on UCSC Golden Path with GeneCards custom track

Promoters for TOX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000224998 608 3601 CTCF MXI1 ZNF777 RAD21 E2F1 GLIS2 POLR2A ZSCAN5C SMC3 RUNX3

Genomic Locations for TOX Gene

Genomic Locations for TOX Gene
313,791 bases
Minus strand

Genomic View for TOX Gene

Genes around TOX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOX Gene

Proteins for TOX Gene

  • Protein details for TOX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thymocyte selection-associated high mobility group box protein TOX
    Protein Accession:
    Secondary Accessions:
    • Q96AV5

    Protein attributes for TOX Gene

    526 amino acids
    Molecular mass:
    57513 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA34528.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TOX Gene

Post-translational modifications for TOX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TOX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TOX Gene

Domains & Families for TOX Gene

Gene Families for TOX Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TOX Gene


Suggested Antigen Peptide Sequences for TOX Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TOX: view

No data available for UniProtKB/Swiss-Prot for TOX Gene

Function for TOX Gene

Molecular function for TOX Gene

UniProtKB/Swiss-Prot Function:
May play a role in regulating T-cell development.

Phenotypes From GWAS Catalog for TOX Gene

Gene Ontology (GO) - Molecular Function for TOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TOX: view
genes like me logo Genes that share phenotypes with TOX: view

Animal Models for TOX Gene

MGI Knock Outs for TOX:

Animal Model Products

miRNA for TOX Gene

miRTarBase miRNAs that target TOX

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TOX Gene

Localization for TOX Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOX Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TOX gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TOX: view

Pathways & Interactions for TOX Gene

genes like me logo Genes that share pathways with TOX: view

Pathways by source for TOX Gene

Gene Ontology (GO) - Biological Process for TOX Gene


No data available for SIGNOR curated interactions for TOX Gene

Drugs & Compounds for TOX Gene

No Compound Related Data Available

Transcripts for TOX Gene

mRNA/cDNA for TOX Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(114) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TOX Gene

Thymocyte selection-associated high mobility group box:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOX Gene

No ASD Table

Relevant External Links for TOX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TOX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TOX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TOX Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.1).

Protein differential expression in normal tissues from HIPED for TOX Gene

This gene is overexpressed in CD8 Tcells (57.3) and Testis (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TOX Gene

Protein tissue co-expression partners for TOX Gene

NURSA nuclear receptor signaling pathways regulating expression of TOX Gene:


SOURCE GeneReport for Unigene cluster for TOX Gene:


Evidence on tissue expression from TISSUES for TOX Gene

  • Nervous system(4.5)
  • Blood(2.4)
  • Intestine(2)
genes like me logo Genes that share expression patterns with TOX: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TOX Gene

Orthologs for TOX Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TOX Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TOX 33 34
  • 99.81 (n)
(Monodelphis domestica)
Mammalia TOX 34
  • 95 (a)
(Canis familiaris)
Mammalia TOX 33 34
  • 93.85 (n)
(Bos Taurus)
Mammalia TOX 33 34
  • 91.38 (n)
(Rattus norvegicus)
Mammalia Tox 33
  • 89.65 (n)
(Mus musculus)
Mammalia Tox 33 16 34
  • 89.16 (n)
(Ornithorhynchus anatinus)
Mammalia TOX 34
  • 86 (a)
(Gallus gallus)
Aves TOX 33 34
  • 85.86 (n)
(Anolis carolinensis)
Reptilia TOX 34
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tox 33
  • 78.65 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1457 33
(Danio rerio)
Actinopterygii tox 33 34
  • 67.73 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POB3 34
  • 6 (a)
Species where no ortholog for TOX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TOX Gene

Gene Tree for TOX (if available)
Gene Tree for TOX (if available)

Paralogs for TOX Gene

Paralogs for TOX Gene

(3) SIMAP similar genes for TOX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TOX: view

Variants for TOX Gene

Sequence variations from dbSNP and Humsavar for TOX Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000002032 -- 58,844,565(+) AGCAT(C/T)GGTAC intron-variant
rs1000004908 -- 59,051,390(+) CGTTG(A/C)GGTAT intron-variant
rs1000005626 -- 59,093,634(+) TTTCT(C/T)CTGCA intron-variant
rs1000010529 -- 59,023,636(+) TGGAA(C/T)AGAGA intron-variant
rs1000025696 -- 59,104,753(+) CAAAA(A/C)ATTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TOX Gene

Variant ID Type Subtype PubMed ID
nsv831327 CNV loss 17160897
nsv6214 CNV insertion 18451855
nsv6213 CNV insertion 18451855
nsv526468 CNV loss 19592680
nsv525018 CNV loss 19592680
nsv1133690 CNV deletion 24896259
nsv1125946 CNV tandem duplication 24896259
nsv1124344 CNV deletion 24896259
esv3417134 CNV insertion 20981092
esv3371312 CNV insertion 20981092
esv3303731 CNV mobile element insertion 20981092
esv2737047 CNV deletion 23290073
esv2737046 CNV deletion 23290073
esv1732094 CNV insertion 17803354
esv1476730 CNV insertion 17803354

Variation tolerance for TOX Gene

Residual Variation Intolerance Score: 76.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.50; 55.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TOX Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOX Gene

Disorders for TOX Gene

MalaCards: The human disease database

(6) MalaCards diseases for TOX Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cutaneous diphtheria
clostridium difficile colitis
  • pseudomembranous colitis
phencyclidine abuse
  • pcp abuse
refractive error
  • refractive errors
- elite association - COSMIC cancer census association via MalaCards
Search TOX in MalaCards View complete list of genes associated with diseases

Relevant External Links for TOX

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TOX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TOX Gene

Publications for TOX Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke MM … Psaty BM (Stroke 2009) 3 45 60
  4. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need AC … Goldstein DB (Human molecular genetics 2009) 3 45 60
  5. Fetal hemoglobin in sickle cell anemia: Bayesian modeling of genetic associations. (PMID: 17918249) Sebastiani P … Steinberg MH (American journal of hematology 2008) 3 45 60

Products for TOX Gene

Sources for TOX Gene

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