TOR4A Gene
protein-coding GIFtS: 35
GCID: GC09P140173
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torsin family 4, member A(Previous name: chromosome 9 open reading frame 167 )
(Previous symbol: C9orf167)
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Aliases
for TOR4A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Torsin Family 4, Member A1 2 | | Chromosome 9 Open Reading Frame 1671 | | C9orf1671 2 3 | | Torsin Family Protein C9orf1672 | | Torsin Family 4 Member A2 3 | | Torsin-4A1 | | FLJ202451 | | |
Export aliases for TOR4A gene to outside databases |
Summaries
for TOR4A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TOR4A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_024000.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TOR4A
Other transcription factors
Search SABiosciences Chromatin IP Primers for TOR4A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOR4A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34.3TOR4A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P140173: view genomic region
(about GC identifiers)
Start:
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140,172,201 bp from pter |
End:
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140,177,093 bp from pter |
Size:
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4,893 bases |
Orientation:
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plus strand |
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Proteins
for TOR4A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TOR4A_HUMAN, Q9NXH8 (See
protein sequence)Recommended Name: Torsin-4A Size: 423 amino acids; 46914 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: A2BFA4Explore the universe of human proteins at neXtProt for TOR4A: NX_Q9NXH8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NXH8
TOR4A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060193.2
ENSEMBL proteins: ENSP00000350102
Human Recombinant Protein Products for TOR4A:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TOR4A for ontologies About GeneDecksing
TOR4A Antibody Products:
Assay Products for TOR4A: |
Protein
Domains /
Families
for TOR4A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TOR4A for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NXH8ProtoNet protein and cluster: Q9NXH8 UniProtKB/Swiss-Prot: TOR4A_HUMAN, Q9NXH8Similarity: Belongs to the clpA/clpB family. Torsin subfamily |
Function
for TOR4A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005524 | ATP binding |
IEA | -- | | GO:0017111 | nucleoside-triphosphatase activity |
IEA | -- |
TOR4A for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOR4A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOR4A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for TOR4A | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TOR4A | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TOR4A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOR4A |
|
Pathways & Interactions
for TOR4A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TOR4A
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TOR4A (ENSP000003501024) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0051085 | chaperone mediated protein folding requiring cofactor |
IEA | -- |
TOR4A for ontologies About GeneDecksing
|
Drugs & Compounds
for TOR4A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TOR4A
Search CenterWatch for drugs/clinical trials and news about TOR4A
|
Transcripts
for TOR4A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TOR4A gene: NM_017723.2 Unigene Cluster for TOR4A: Torsin family 4, member A Hs.495541 [show with all ESTs]Unigene Representative Sequence: AK0002521 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000357503(uc004cmn.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOR4A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOR4A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for TOR4A | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TOR4A | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TOR4A |
Additional cDNA sequence: AK000252.1 AK000392.1 AK023361.1 2 DOTS entries: DT.429575 DT.100711089 24/65 AceView cDNA sequences (see all 65): BM822651 AA375108 BM831410 BF002149 AI343420 AI540176 AW592236 AI805162 AI215491 CB305651 AW204151 AI597732 BM796278 BQ224727 AI889841 AK023361 BG034769 AK000252 AW300836 BM850483 BM991995 BM833292 AI720141 AW075902
GeneLoc Exon Structure
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Expression
for TOR4A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See TOR4A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TOR4A
SOURCE GeneReport for Unigene cluster: Hs.495541
SABiosciences Custom PCR Arrays for TOR4A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOR4A
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TOR4A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOR4A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOR4A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOR4A |
Orthologs
for TOR4A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TOR4A gene from 4/12 species (see all 12) About this table
ENSEMBL Gene Tree for TOR4A (if available)
TreeFam Gene Tree for TOR4A (if available) |
Paralogs
for TOR4A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TOR4A gene
- TOR1A2 TOR2A2 TOR1B2 TOR3A2
TOR4A for paralogs About GeneDecksing
|
Genomic Variants
for TOR4A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TOR4A (140172201 - 140177093 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TOR4A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOR4A |
|
Disorders
/ Diseases
for TOR4A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TOR4A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TOR4A gene integrated from 9 sources:
(articles sorted by number of sources associating them with TOR4A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
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External Searches for TOR4A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TOR4A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TOR4A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TOR4A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TOR4A | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TOR4A gene:
Search GeneIP for patents involving TOR4A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TOR4A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TOR4A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TOR4A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOR4A | | | OriGene Protein Over-expression Lysate for TOR4A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TOR4A | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOR4A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOR4A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TOR4A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOR4A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOR4A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOR4A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOR4A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOR4A |
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 |  |  |  | |
| | | | Search Tocris compounds for TOR4A |
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 | | | TOR4A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOR4A |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TOR4A |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TOR4A |
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