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Aliases for TOR4A Gene

Aliases for TOR4A Gene

  • Torsin Family 4 Member A 2 3 4
  • Torsin Family 4, Member A 2 3 5
  • C9orf167 3 4
  • Chromosome 9 Open Reading Frame 167 2
  • Torsin Family Protein C9orf167 3

External Ids for TOR4A Gene

Previous HGNC Symbols for TOR4A Gene

  • C9orf167

Previous GeneCards Identifiers for TOR4A Gene

  • GC09P140173

Summaries for TOR4A Gene

GeneCards Summary for TOR4A Gene

TOR4A (Torsin Family 4 Member A) is a Protein Coding gene. An important paralog of this gene is TOR2A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOR4A Gene

Genomics for TOR4A Gene

Regulatory Elements for TOR4A Gene

Promoters for TOR4A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TOR4A on UCSC Golden Path with GeneCards custom track

Genomic Location for TOR4A Gene

Chromosome:
9
Start:
137,277,749 bp from pter
End:
137,282,641 bp from pter
Size:
4,893 bases
Orientation:
Plus strand

Genomic View for TOR4A Gene

Genes around TOR4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOR4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOR4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOR4A Gene

Proteins for TOR4A Gene

  • Protein details for TOR4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXH8-TOR4A_HUMAN
    Recommended name:
    Torsin-4A
    Protein Accession:
    Q9NXH8
    Secondary Accessions:
    • A2BFA4

    Protein attributes for TOR4A Gene

    Size:
    423 amino acids
    Molecular mass:
    46914 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TOR4A Gene

Proteomics data for TOR4A Gene at MOPED

Post-translational modifications for TOR4A Gene

  • Ubiquitination at Lys 75
  • Modification sites at PhosphoSitePlus

Other Protein References for TOR4A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TOR4A Gene

Domains & Families for TOR4A Gene

Protein Domains for TOR4A Gene

Suggested Antigen Peptide Sequences for TOR4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NXH8

UniProtKB/Swiss-Prot:

TOR4A_HUMAN :
  • Belongs to the ClpA/ClpB family. Torsin subfamily.
Family:
  • Belongs to the ClpA/ClpB family. Torsin subfamily.
genes like me logo Genes that share domains with TOR4A: view

No data available for Gene Families for TOR4A Gene

Function for TOR4A Gene

genes like me logo Genes that share phenotypes with TOR4A: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TOR4A Gene

Localization for TOR4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOR4A Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TOR4A Gene COMPARTMENTS Subcellular localization image for TOR4A gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for TOR4A Gene

Pathways & Interactions for TOR4A Gene

SuperPathways for TOR4A Gene

No Data Available

Interacting Proteins for TOR4A Gene

Gene Ontology (GO) - Biological Process for TOR4A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TOR4A Gene

Drugs & Compounds for TOR4A Gene

No Compound Related Data Available

Transcripts for TOR4A Gene

mRNA/cDNA for TOR4A Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(65) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TOR4A Gene

Torsin family 4, member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TOR4A Gene

No ASD Table

Relevant External Links for TOR4A Gene

GeneLoc Exon Structure for
TOR4A
ECgene alternative splicing isoforms for
TOR4A

Expression for TOR4A Gene

mRNA expression in normal human tissues for TOR4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TOR4A Gene

This gene is overexpressed in Whole Blood (x7.6).

Protein differential expression in normal tissues from HIPED for TOR4A Gene

This gene is overexpressed in Nasal epithelium (33.2), Peripheral blood mononuclear cells (17.9), and Platelet (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TOR4A Gene



SOURCE GeneReport for Unigene cluster for TOR4A Gene Hs.495541

genes like me logo Genes that share expression patterns with TOR4A: view

Protein tissue co-expression partners for TOR4A Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TOR4A Gene

Orthologs for TOR4A Gene

This gene was present in the common ancestor of animals.

Orthologs for TOR4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOR4A 36
  • 100 (a)
OneToOne
TOR4A 35
  • 99.61 (n)
  • 99.53 (a)
cow
(Bos Taurus)
Mammalia TOR4A 36
  • 80 (a)
OneToOne
TOR4A 35
  • 82.76 (n)
  • 79.8 (a)
dog
(Canis familiaris)
Mammalia TOR4A 35
  • 84.32 (n)
  • 83.22 (a)
TOR4A 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tor4a 16
Tor4a 36
  • 77 (a)
OneToOne
Tor4a 35
  • 74.84 (n)
  • 79.33 (a)
oppossum
(Monodelphis domestica)
Mammalia TOR4A 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TOR4A 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tor4a 35
  • 76 (n)
  • 79.19 (a)
chicken
(Gallus gallus)
Aves C9ORF167 35
  • 61.13 (n)
  • 53.06 (a)
TOR4A 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TOR4A 36
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tor4a 35
  • 59.03 (n)
  • 51.49 (a)
zebrafish
(Danio rerio)
Actinopterygii TOR4A (1 of 4) 36
  • 43 (a)
OneToMany
TOR4A (2 of 4) 36
  • 43 (a)
OneToMany
TOR4A (3 of 4) 36
  • 43 (a)
OneToMany
TOR4A (4 of 4) 36
  • 43 (a)
OneToMany
LOC101886311 35
  • 54.86 (n)
  • 48.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta Torsin 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ooc-5 36
  • 20 (a)
ManyToMany
tor-1 36
  • 20 (a)
ManyToMany
tor-2 36
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7178 36
  • 17 (a)
OneToMany
Species with no ortholog for TOR4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TOR4A Gene

ENSEMBL:
Gene Tree for TOR4A (if available)
TreeFam:
Gene Tree for TOR4A (if available)

Paralogs for TOR4A Gene

Paralogs for TOR4A Gene

genes like me logo Genes that share paralogs with TOR4A: view

Variants for TOR4A Gene

Sequence variations from dbSNP and Humsavar for TOR4A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs9802654 -- 137,281,796(+) AACCA(G/T)GGCTG utr-variant-3-prime
rs35570830 -- 137,282,182(+) GGAAA(-/A)TTTTA utr-variant-3-prime
rs58259425 -- 137,283,104(+) ATTAC(A/G)TAGTA downstream-variant-500B
rs58430867 -- 137,282,920(+) TAACT(-/AAA)AAAGT downstream-variant-500B
rs28568884 -- 137,281,797(+) ACCAG(C/G)GCTGA utr-variant-3-prime

Variation tolerance for TOR4A Gene

Gene Damage Index Score: 2.96; 49.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TOR4A Gene

HapMap Linkage Disequilibrium report
TOR4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TOR4A Gene

Disorders for TOR4A Gene

Relevant External Links for TOR4A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TOR4A

No disorders were found for TOR4A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TOR4A Gene

Publications for TOR4A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PMID: 23956138) Foerster S. … Ritter C.A. (Proteomics 2013) 3
  3. Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PMID: 22952844) Wu Z. … Ma L. (PLoS ONE 2012) 3

Products for TOR4A Gene

Sources for TOR4A Gene

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