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Aliases for TOR4A Gene

Aliases for TOR4A Gene

  • Torsin Family 4, Member A 2 3
  • Torsin Family 4 Member A 3 4
  • C9orf167 3 4
  • Chromosome 9 Open Reading Frame 167 2
  • Torsin Family Protein C9orf167 3
  • Torsin-4A 3

External Ids for TOR4A Gene

Previous HGNC Symbols for TOR4A Gene

  • C9orf167

Previous GeneCards Identifiers for TOR4A Gene

  • GC09P140173

Summaries for TOR4A Gene

GeneCards Summary for TOR4A Gene

TOR4A (Torsin Family 4, Member A) is a Protein Coding gene. GO annotations related to this gene include nucleoside-triphosphatase activity. An important paralog of this gene is TOR2A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOR4A Gene

Genomics for TOR4A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TOR4A Gene

Start:
137,277,749 bp from pter
End:
137,282,641 bp from pter
Size:
4,893 bases
Orientation:
Plus strand

Genomic View for TOR4A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TOR4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOR4A Gene

No data available for Regulatory Elements for TOR4A Gene

Proteins for TOR4A Gene

  • Protein details for TOR4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXH8-TOR4A_HUMAN
    Recommended name:
    Torsin-4A
    Protein Accession:
    Q9NXH8
    Secondary Accessions:
    • A2BFA4

    Protein attributes for TOR4A Gene

    Size:
    423 amino acids
    Molecular mass:
    46914 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TOR4A Gene

Proteomics data for TOR4A Gene at MOPED

Post-translational modifications for TOR4A Gene

  • Ubiquitination at Lys75
  • Modification sites at PhosphoSitePlus

Other Protein References for TOR4A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TOR4A Gene

Domains for TOR4A Gene

Protein Domains for TOR4A Gene

Graphical View of Domain Structure for InterPro Entry

Q9NXH8

UniProtKB/Swiss-Prot:

TOR4A_HUMAN :
  • Q9NXH8
Family:
  • Belongs to the ClpA/ClpB family. Torsin subfamily.
genes like me logo Genes that share domains with TOR4A: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for TOR4A Gene

Function for TOR4A Gene

Gene Ontology (GO) - Molecular Function for TOR4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with TOR4A: view

Animal Model Products

CRISPR Products

miRNA for TOR4A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TOR4A Gene

Localization for TOR4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOR4A Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TOR4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TOR4A: view

No data available for Subcellular locations from COMPARTMENTS for TOR4A Gene

Pathways for TOR4A Gene

SuperPathways for TOR4A Gene

No Data Available

Interacting Proteins for TOR4A Gene

Gene Ontology (GO) - Biological Process for TOR4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051085 chaperone mediated protein folding requiring cofactor --
genes like me logo Genes that share ontologies with TOR4A: view

No data available for Pathways by source for TOR4A Gene

Transcripts for TOR4A Gene

mRNA/cDNA for TOR4A Gene

(65) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TOR4A Gene

Torsin family 4, member A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TOR4A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TOR4A
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOR4A Gene

No ASD Table

Relevant External Links for TOR4A Gene

GeneLoc Exon Structure for
TOR4A
ECgene alternative splicing isoforms for
TOR4A

Expression for TOR4A Gene

mRNA expression in normal human tissues for TOR4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TOR4A Gene

This gene is overexpressed in Whole Blood (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TOR4A Gene

SOURCE GeneReport for Unigene cluster for TOR4A Gene Hs.495541

genes like me logo Genes that share expressions with TOR4A: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TOR4A Gene

Orthologs for TOR4A Gene

This gene was present in the common ancestor of animals.

Orthologs for TOR4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOR4A 35
  • 99.61 (n)
  • 99.53 (a)
TOR4A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TOR4A 35
  • 82.76 (n)
  • 79.8 (a)
TOR4A 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TOR4A 35
  • 84.32 (n)
  • 83.22 (a)
TOR4A 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tor4a 35
  • 74.84 (n)
  • 79.33 (a)
Tor4a 16
Tor4a 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TOR4A 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TOR4A 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tor4a 35
  • 76 (n)
  • 79.19 (a)
chicken
(Gallus gallus)
Aves C9ORF167 35
  • 61.13 (n)
  • 53.06 (a)
TOR4A 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TOR4A 36
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tor4a 35
  • 59.03 (n)
  • 51.49 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101886311 35
  • 54.86 (n)
  • 48.73 (a)
TOR4A (1 of 4) 36
  • 43 (a)
OneToMany
TOR4A (2 of 4) 36
  • 43 (a)
OneToMany
TOR4A (3 of 4) 36
  • 43 (a)
OneToMany
TOR4A (4 of 4) 36
  • 43 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Torsin 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ooc-5 36
  • 20 (a)
ManyToMany
tor-1 36
  • 20 (a)
ManyToMany
tor-2 36
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7178 36
  • 17 (a)
OneToMany
Species with no ortholog for TOR4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TOR4A Gene

ENSEMBL:
Gene Tree for TOR4A (if available)
TreeFam:
Gene Tree for TOR4A (if available)

Paralogs for TOR4A Gene

Paralogs for TOR4A Gene

genes like me logo Genes that share paralogs with TOR4A: view

Variants for TOR4A Gene

Sequence variations from dbSNP and Humsavar for TOR4A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs9802434 -- 137,281,268(+) GAAGG(A/T)GGAGG utr-variant-3-prime
rs9802435 -- 137,281,294(+) AGCCC(A/C)GAGTC utr-variant-3-prime
rs9802654 -- 137,281,796(+) AACCA(G/T)GGCTG utr-variant-3-prime
rs13301565 -- 137,282,588(+) CTGGT(A/T)ATAAA utr-variant-3-prime
rs28455773 -- 137,281,842(+) CTAGG(G/T)GAAGG utr-variant-3-prime

Relevant External Links for TOR4A Gene

HapMap Linkage Disequilibrium report
TOR4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TOR4A Gene

Disorders for TOR4A Gene

No disorders were found for TOR4A Gene.

No data available for UniProtKB/Swiss-Prot for TOR4A Gene

Publications for TOR4A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  4. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PMID: 21987572) Lee K.A. … Doedens J.R. (J. Biol. Chem. 2011) 3
  5. Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PMID: 22952844) Wu Z. … Ma L. (PLoS ONE 2012) 3

Products for TOR4A Gene

Sources for TOR4A Gene

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