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TOR3A Gene

protein-coding   GIFtS: 52
GCID: GC01P179050

Torsin Family 3, Member A

(Previous name: ATP-dependant interferon responsive)
(Previous symbol: ADIR)
  See TOR3A-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Torsin Family 3, Member A1 2     ADIR22
ADIR1 2 3 5     ATP-Dependant Interferon Response Protein 12
ATP-Dependant Interferon Responsive1 2     torsin-3A2
ATP-Dependent Interferon-Responsive Protein2 3     Torsin Family 3 Member A3

External Ids:    HGNC: 119971   Entrez Gene: 642222   Ensembl: ENSG000001862837   OMIM: 6075555   UniProtKB: Q9H4973   

Export aliases for TOR3A gene to outside databases

Previous GC identifers: GC00U990670 GC01P174479 GC01U900786 GC01P176290 GC01P175782 GC01P177317 GC01P150279


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TOR3A Gene:
TOR3A (torsin family 3, member A) is a protein-coding gene. Diseases associated with TOR3A include torsion dystonia. An important paralog of this gene is TOR1A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TOR3A gene promoter:
         Nkx3-1   Nkx3-1 v4   Pax-5   Nkx3-1 v1   AREB6   Nkx3-1 v2   Chx10   Nkx3-1 v3   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTOR3A promoter sequence
   Search Chromatin IP Primers for TOR3A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TOR3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.2   Ensembl cytogenetic band:  1q25.2   HGNC cytogenetic band: 1q25.2

TOR3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOR3A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P179050:  view genomic region     (about GC identifiers)

Start:
179,050,512 bp from pter      End:
179,067,158 bp from pter
Size:
16,647 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TOR3A_HUMAN, Q9H497 (See protein sequence)
Recommended Name: Torsin-3A precursor  
Size: 397 amino acids; 46199 Da
Secondary accessions: B4DSY0 B7ZB65 Q5M7Y7 Q8WVA7 Q8WWM2 Q9H495 Q9H6E7
Alternative splicing: 3 isoforms:  Q9H497-1   Q9H497-2   Q9H497-3   

Explore the universe of human proteins at neXtProt for TOR3A: NX_Q9H497

Explore proteomics data for TOR3A at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn122
  • Modification sites at PhosphoSitePlus

  • See TOR3A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071766.2  
    ENSEMBL proteins: 
     ENSP00000356599   ENSP00000356597   ENSP00000435744   ENSP00000335351   ENSP00000410195  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR010448 Torsin

    Graphical View of Domain Structure for InterPro Entry Q9H497

    ProtoNet protein and cluster: Q9H497

    1 Blocks protein domain: IPB010448 Torsin

    UniProtKB/Swiss-Prot: TOR3A_HUMAN, Q9H497
    Similarity: Belongs to the ClpA/ClpB family. Torsin subfamily


    Find genes that share domains with TOR3A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0016887ATPase activity IDA--
         
    Find genes that share ontologies with TOR3A           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TOR3A:
     Decreased viability with pacli  Increased cell number in G2M,   Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TOR3A
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    hsa-mir-124-3p (MIRT022168), hsa-mir-192-5p (MIRT026137), hsa-mir-215-5p (MIRT024534)

    Block miRNA regulation of human, mouse, rat TOR3A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TOR3A (see all 9):
    hsa-miR-3910 hsa-miR-124 hsa-miR-362-3p hsa-miR-593* hsa-miR-506 hsa-miR-590-3p hsa-miR-4282 hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidTOR3A 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TOR3A_HUMAN, Q9H497: Cytoplasm. Endoplasmic reticulum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular2
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA11863361
    GO:0005788endoplasmic reticulum lumen IDA11863361
    GO:0070062extracellular vesicular exosome IDA19199708

    Find genes that share ontologies with TOR3A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TOR3A
    Interactions:

        Search GeneGlobe Interaction Network for TOR3A

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for TOR3A (ENSP000003565994) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TOR1AIP1ENSP000002715834STRING: ENSP00000271583
    NAGLUENSP000002259274STRING: ENSP00000225927
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process IDA--
    GO:0008150biological_process ND--
    GO:0051085chaperone mediated protein folding requiring cofactor IEA--

    Find genes that share ontologies with TOR3A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TOR3A



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TOR3A gene: 
    NM_022371.3  

    Unigene Cluster for TOR3A:

    Torsin family 3, member A
    Hs.584957  [show with all ESTs]
    Unigene Representative Sequence: NM_022371
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367627(uc001gmd.3 uc010pnd.2) ENST00000367625 ENST00000483887
    ENST00000352445 ENST00000472001 ENST00000447595 ENST00000495145
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TOR3A (see all 9):
    hsa-miR-3910 hsa-miR-124 hsa-miR-362-3p hsa-miR-593* hsa-miR-506 hsa-miR-590-3p hsa-miR-4282 hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidTOR3A 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TOR3A
      QuantiFast Probe-based Assays in human, mouse, rat TOR3A

    Additional mRNA sequence: 

    AJ299403.1 AJ299441.1 AK025998.1 AK130132.1 AK299966.1 AK316530.1 BC001085.1 BC007571.1 
    BC011746.1 BC018292.1 BC088368.1 CR457354.1 

    12 DOTS entries:

    DT.310502  DT.95085651  DT.86850469  DT.100813087  DT.92440113  DT.121446640  DT.100033617  DT.100755319 
    DT.86847176  DT.100766445  DT.97846344  DT.121446592 

    Selected AceView cDNA sequences (see all 233):

    BU623969 BQ884301 BI910959 BQ278781 BF510505 AW582913 BX355234 BQ691862 
    BM905644 AW297716 CR600139 AA775388 BQ061399 BG330135 BU738533 AJ299403 
    BP340000 BQ422117 BQ642330 BQ278718 BQ056266 CR612199 AI553657 CR614363 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TOR3A (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9
    SP1:                                      -     -           -     -                                         -     -     -     -         
    SP2:                                      -     -           -     -                                                                     
    SP3:                                      -     -           -     -     -     -                                                         
    SP4:                                      -     -           -     -     -                                                               
    SP5:                                      -                 -     -                                                                     


    ECgene alternative splicing isoforms for TOR3A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TOR3A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGTTGTAT
    TOR3A Expression
    About this image

    TOR3A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TOR3A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.584957

    UniProtKB/Swiss-Prot: TOR3A_HUMAN, Q9H497
    Tissue specificity: Ubiquitously expressed. Highest expression in stomach, salivary glands and lymph nodes.
    Isoform 2 is expressed in placenta

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TOR3A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tor3a1 , 5 torsin family 3, member A1, 5 78.33(n)1
    71.94(a)1
      1 (67.71 cM)5
    309351  NM_023141.21  NP_075630.21 
     1566536175 
    chicken
    (Gallus gallus)
    Aves TOR3A1 torsin family 3, member A 67.73(n)
    59.73(a)
      424426  XM_422270.3  XP_422270.1 
    lizard
    (Anolis carolinensis)
    Reptilia TOR3A6
    torsin family 3, member A
    55(a)
    1 ↔ 1
    GL343300.1(878441-903555)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tor3a1 torsin family 3, member A 54.26(n)
    45(a)
      594980  NM_001030421.2  NP_001025592.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tor3a1 torsin family 3, member A 60.76(n)
    53.49(a)
      792835  NM_001128266.1  NP_001121738.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Torsin6
    Torsin
    27(a)
    1 → many
    X(4542625-4543865)
    worm
    (Caenorhabditis elegans)
    Secernentea tor-16
    ooc-56
    (see all 3)
    Protein TOR-1 (tor-1) mRNA, complete cds
    Protein OOC-5, isoform b (ooc-5) mRNA, complete cd...
    (see all 3)
    29(a)
    27(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    IV(13984251-13985693) WBGene00006597
    II(8993169-8994535) WBGene00003870


    ENSEMBL Gene Tree for TOR3A (if available)
    TreeFam Gene Tree for TOR3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TOR3A gene
    TOR1A2  TOR2A2  TOR4A2  TOR1B2  
    3 SIMAP similar genes for TOR3A using alignment to 4 protein entries:     TOR3A_HUMAN (see all proteins):
    TOR1B    TOR1A    TOR2A

    Find genes that share paralogs with TOR3A           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TOR3A
    PGOHUM00000243269


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TOR3A (see all 410)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs574691131,2
    F--179049184(+) AAACTA/GTTGTT 1 -- us2k11Minor allele frequency- G:0.02EA 120
    rs1929605141,2
    --179049254(+) CTTGCC/GTCCTG 1 -- us2k10--------
    rs1497011551,2
    --179049406(+) TTTTTA/TTAGGT 1 -- us2k10--------
    rs1844135231,2
    --179049419(+) GGAAAC/TAGGCA 1 -- us2k10--------
    rs752511331,2
    C--179049538(+) CTTTTC/TTCTTT 1 -- us2k13Minor allele frequency- T:0.08NA EA 242
    rs668316721,2
    C--179049547(+) TTTCT-/TTTTTTT 1 -- us2k10--------
    rs770678941,2
    --179049547(+) TTTTTC/TTTTTT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs104583671,2
    C,F,A--179049606(+) AGTGGC/TACCAT 1 -- us2k17Minor allele frequency- T:0.19NA WA CSA 16
    rs1891936511,2
    C--179049649(+) CAAGCC/TATTCT 1 -- us2k10--------
    rs1819094021,2
    --179049777(+) CTGATC/TTCAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TOR3A (179050512 - 179067158 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TOR3A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658665CNV Deletion23128226
    nsv3721CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607555    OMIM disorders: --

    1 disease for TOR3A:    
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    torsion dystonia


    Find genes that share disorders with TOR3A           About GenesLikeMe

    Genetic Association Database (GAD): TOR3A
    Human Genome Epidemiology (HuGE) Navigator: TOR3A (2 documents)

    Export disorders for TOR3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TOR3A gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with TOR3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of ADIR, a novel interferon responsive gene encoding a protein related to the torsins. (PubMed id 11863361)1, 2, 9 Dron M....Tovey M.G. (Genomics 2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The TOR1A (DYT1) gene family and its role in early onset torsion dystonia. (PubMed id 10644435)1, 3 Ozelius L.J....Breakefield X.O. (Genomics 1999)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    10. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64222 HGNC: 11997 AceView: TOR3A Ensembl:ENSG00000186283 euGenes: HUgn64222
    ECgene: TOR3A H-InvDB: TOR3A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TOR3A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TOR3A gene:
    Search GeneIP for patents involving TOR3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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