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TOR2A Gene

protein-coding   GIFtS: 52
GCID: GC09M130493

Torsin Family 2, Member A

  See TOR2A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Torsin Family 2, Member A1 2     torsin-2A2
Torsin-Related Protein 12 3     Torsin-2A3
TORP12 3     Torsin Family 2 Member A3
prosalusin2     

External Ids:    HGNC: 119961   Entrez Gene: 274332   Ensembl: ENSG000001604047   OMIM: 6080525   UniProtKB: Q5JU693   
UniProtKB: Q8N2E63   

Export aliases for TOR2A gene to outside databases

Previous GC identifers: GC09M121608 GC09M122140 GC09M123947 GC09M125869 GC09M127573 GC09M129533 GC09M100110


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TOR2A Gene:
This gene encodes a member of the AAA family of adenosine triphosphatases with similarity to Clp proteases and
heat shock proteins. Alternative splicing at this locus results in the translation of multiple isoforms of the
encoded protein, some of which contain salusin peptides in the C-terminal region. These peptides may play roles
in hypotension, myocardial growth and the induction of mitogenesis, and may also be involved in the pathogenesis
of atherosclerosis. (provided by RefSeq, Oct 2011)

GeneCards Summary for TOR2A Gene:
TOR2A (torsin family 2, member A) is a protein-coding gene. Diseases associated with TOR2A include torsion dystonia, and atherosclerosis. GO annotations related to this gene include hormone activity and nucleoside-triphosphatase activity. An important paralog of this gene is TOR1A.

UniProtKB/Swiss-Prot: TOR2X_HUMAN, Q8N2E6
Function: Salusins -alpha and -beta may be endocrine and/or paracrine factors able to increase intracellular
calcium concentrations and induce cell mitogenesis. Salusins may also be potent hypotensive peptides

Gene Wiki entry for TOR2A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TOR2A gene promoter:
         Max1   NF-1   p300   MyoD   AP-4   RORalpha1   PPAR-gamma1   PPAR-gamma2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTOR2A promoter sequence
   Search Chromatin IP Primers for TOR2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TOR2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.11

TOR2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOR2A gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M130493:  view genomic region     (about GC identifiers)

Start:
130,493,803 bp from pter      End:
130,497,604 bp from pter
Size:
3,802 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TOR2A_HUMAN, Q5JU69 (See protein sequence)
Recommended Name: Torsin-2A precursor  
Size: 321 amino acids; 35714 Da
Sequence caution: Sequence=AAH80527.2; Type=Erroneous translation; Note=Wrong choice of frame;
Sequence=AAI00908.2; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=AAI00909.2;
Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=AAI00910.2; Type=Miscellaneous
discrepancy; Note=Probable cloning artifact; Sequence=AAI00911.2; Type=Miscellaneous discrepancy; Note=Probable
cloning artifact;
Secondary accessions: A4FU12 A4FU13 Q3ZCN9 Q3ZCP0 Q5JU68 Q66K87 Q6UXW6 Q8NAN5 Q96SL7
Alternative splicing: 4 isoforms:  Q5JU69-1   Q5JU69-2   Q5JU69-5   Q8N2E6-1   (Salusins -alpha and -beta peptides are derived from isoform 4)

UniProtKB/Swiss-Prot: TOR2X_HUMAN, Q8N2E6 (See protein sequence)

Recommended Name: Prosalusin precursor  
Size: 242 amino acids; 26262 Da
Alternative splicing: 4 isoforms:  Q8N2E6-1   Q5JU69-1   Q5JU69-2   Q5JU69-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TOR2A: NX_Q8N2E6

Explore proteomics data for TOR2A at MOPED

Post-translational modifications: 

  • Amidation of salusin-alpha(29-Gly) by peptidylglycine alpha-amidating monooxygenase, PAM, converts Lys-241-Gly-242
    to Lys-241-NH2 and gives raise to salusin-alpha1
  • Glycosylation2 at Asn149

  • See TOR2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001078816.1  NP_001127902.1  NP_001127903.1  NP_001238947.1  NP_001238950.1  NP_001238952.1  NP_569726.2  

    ENSEMBL proteins: 
     ENSP00000338317   ENSP00000362381   ENSP00000362378   ENSP00000413032  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR017378 Torsin_subgr
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase
     IPR001270 ClpA/B
     IPR010448 Torsin

    Graphical View of Domain Structure for InterPro Entry Q5JU69
    Graphical View of Domain Structure for InterPro Entry Q8N2E6

    ProtoNet protein and cluster: Q5JU69

    1 Blocks protein domain: IPB010448 Torsin

    UniProtKB/Swiss-Prot: TOR2A_HUMAN, Q5JU69
    Similarity: Belongs to the ClpA/ClpB family. Torsin subfamily

    UniProtKB/Swiss-Prot: TOR2X_HUMAN, Q8N2E6
    Similarity: Belongs to the ClpA/ClpB family. Torsin subfamily


    Find genes that share domains with TOR2A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TOR2X_HUMAN, Q8N2E6
    Function: Salusins -alpha and -beta may be endocrine and/or paracrine factors able to increase intracellular
    calcium concentrations and induce cell mitogenesis. Salusins may also be potent hypotensive peptides

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005179hormone activity IEA--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0017111nucleoside-triphosphatase activity IEA--
         
    Find genes that share ontologies with TOR2A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TOR2A:
     Decreased Tat-dependent transc 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidTOR2A 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TOR2A_HUMAN, Q5JU69: Secreted (Probable)
    TOR2X_HUMAN, Q8N2E6: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular5
    lysosome1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005783endoplasmic reticulum ----
    GO:0005788endoplasmic reticulum lumen IDA--

    Find genes that share ontologies with TOR2A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TOR2A
    Interactions:

        Search GeneGlobe Interaction Network for TOR2A

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for TOR2A (ENSP000003623814) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TOR1AIP1ENSP000002715834STRING: ENSP00000271583
    NAGLUENSP000002259274STRING: ENSP00000225927
    --ENSP000003809914STRING: ENSP00000380991
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051085chaperone mediated protein folding requiring cofactor IEA--
    GO:0051260protein homooligomerization IDA--

    Find genes that share ontologies with TOR2A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TOR2A (TOR2X)

    1 HMDB Compound for TOR2A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TOR2A gene (7 alternative transcripts): 
    NM_001085347.2  NM_001134430.2  NM_001134431.2  NM_001252018.1  NM_001252021.1  NM_001252023.1  NM_130459.3  

    Unigene Cluster for TOR2A:

    Torsin family 2, member A
    Hs.444106  [show with all ESTs]
    Unigene Representative Sequence: NM_130459
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336067 ENST00000373284(uc004brs.4 uc004brt.4) ENST00000373281(uc004brw.4)
    ENST00000463577 ENST00000472723 ENST00000463256 ENST00000496460 ENST00000494135
    ENST00000493439 ENST00000458505(uc022bnq.1 uc004bru.4 uc004brv.4 uc011maj.2)

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    Additional mRNA sequence: 

    AK027677.1 AK055034.1 AK075520.1 AY358180.1 BC022985.1 BC062340.1 BC080527.1 BC100907.1 
    BC100908.2 BC100909.2 BC100910.1 

    13 DOTS entries:

    DT.97797693  DT.100793360  DT.95362358  DT.121191740  DT.95266584  DT.100793363  DT.438963  DT.443433 
    DT.100703386  DT.121191703  DT.121191734  DT.91701773  DT.91741616 

    19 AceView cDNA sequences:

    BC032411 BM987973 NM_144965 AK057342 BI560277 BC031281 BI908416 AA235536 
    AA410617 AK074105 AK128011 BX106476 BF951564 AA813084 BE138646 AW268779 
    AW302989 BF851621 W22172 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TOR2A (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f
    SP1:                                            -     -     -           -                                       
    SP2:                          -     -           -     -     -           -                                       
    SP3:                                            -     -     -     -     -                                       
    SP4:                          -     -           -     -     -     -     -                                       
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for TOR2A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TOR2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGAAAGGC
    TOR2A Expression
    About this image


    TOR2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Eye (Sensory Organs)
             Retina
     
     Ovary (Reproductive System)
     
     Placenta (Extraembryonic Tissues)
    TOR2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TOR2A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.444106

    UniProtKB/Swiss-Prot: TOR2A_HUMAN, Q5JU69
    Tissue specificity: Isoform 1 is expressed ubiquitously, except in cardiac and endothelial tissues

    UniProtKB/Swiss-Prot: TOR2X_HUMAN, Q8N2E6
    Tissue specificity: Isoform 4 is ubiquitously expressed, with high level in vascular endothelial cells and
    vascular smooth muscle cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TOR2A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tor2a1 , 5 torsin family 2, member A1, 5 85.67(n)1
    86.6(a)1
      2 (22.09 cM)5
    309331  NM_152800.31  NP_690013.11 
     327572345 
    chicken
    (Gallus gallus)
    Aves TOR2A1 torsin family 2, member A 71.05(n)
    64.54(a)
      417224  XM_415507.4  XP_415507.4 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.69042 Xenopus laevis transcribed sequences 72.73(n)    BJ613421.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tor2a1 torsin family 2, member A 54.31(n)
    46.6(a)
      559805  NM_001034180.2  NP_001029352.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Torsin6
    Torsin
    28(a)
    1 → many
    X(4542625-4543865)
    worm
    (Caenorhabditis elegans)
    Secernentea tor-16
    ooc-56
    (see all 3)
    Protein TOR-1 (tor-1) mRNA, complete cds
    Protein OOC-5, isoform b (ooc-5) mRNA, complete cd...
    (see all 3)
    34(a)
    32(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    IV(13984251-13985693) WBGene00006597
    II(8993169-8994535) WBGene00003870


    ENSEMBL Gene Tree for TOR2A (if available)
    TreeFam Gene Tree for TOR2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TOR2A gene
    TOR1A2  TOR4A2  TOR1B2  TOR3A2  
    3 SIMAP similar genes for TOR2A using alignment to 2 protein entries:     TOR2A_HUMAN (see all proteins):
    TOR1A    TOR1B    TOR3A

    Find genes that share paralogs with TOR2A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TOR2A (see all 159)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs346418401,2
    C--130498538(+) CACAC-/AC/C  
      A
    /CACA
    GACTT
    7 -- us2k10--------
    rs1384066591,2
    --130498606(+) AGAAAC/TAAGTA 7 -- us2k10--------
    rs1916040521,2
    --130498687(+) ATGGCA/GAAACC 7 -- us2k10--------
    rs1133349941,2
    F--130498879(+) GAAAAG/CAGAGA 7 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs1176715931,2
    C,F--130498914(+) GAAAGG/TAAAGA 7 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1453335441,2
    C--130498935(+) AAGAA-/AAAG  
            
    AAAGA
    7 -- us2k10--------
    rs1837370091,2
    --130499020(+) AAAGAA/GAGGAA 7 -- us2k10--------
    rs1895992871,2
    --130499030(+) AGGAAA/GGAAGG 7 -- us2k10--------
    rs1932314911,2
    C--130499103(+) GGATCA/CCAAGG 7 -- us2k10--------
    rs1120497001,2
    C,F--130499181(+) CTGGGC/TGTAGT 7 -- us2k11Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for TOR2A (130493803 - 130497604 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for TOR2A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv893870CNV Loss21882294
    nsv466571CNV Loss19166990
    nsv893868CNV Loss21882294
    nsv893865CNV Loss21882294
    nsv471323CNV Loss18288195
    nsv893867CNV Loss21882294
    dgv8287n71CNV Loss21882294
    nsv893859CNV Loss21882294
    nsv893860CNV Gain21882294
    nsv893866CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TOR2A
    DNA2.0 Custom Variant and Variant Library Synthesis for TOR2A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608052    OMIM disorders: --

    2 diseases for TOR2A:    
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    torsion dystonia    atherosclerosis


    Find genes that share disorders with TOR2A           About GenesLikeMe

    Genetic Association Database (GAD): TOR2A
    Human Genome Epidemiology (HuGE) Navigator: TOR2A (1 document)

    Export disorders for TOR2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TOR2A gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with TOR2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Salusins: newly identified bioactive peptides with hemodynamic and mitogenic activities. (PubMed id 12910263)1, 2, 9 Shichiri M.... Hirata Y. (Nat. Med. 2003)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    4. The TOR1A (DYT1) gene family and its role in early onset torsion dystonia. (PubMed id 10644435)1, 3 Ozelius L.J....Breakefield X.O. (Genomics 1999)
    5. Salusins, newly identified regulators of hemodynamics and mitogenesis, increase in polycystic ovarian syndrome. (PubMed id 22827297)1 Celik A.9....Aydin S. (Gynecol. Endocrinol. 2013)
    6. Serum levels of apelin, salusin-alpha and salusin-beta in normal pregnancy and preeclampsia. (PubMed id 22533552)1 Simsek Y....Ozer A. (amp 2012)
    7. [Physicochemical characteristics of salusin-beta and establishment of the radioimmunoassay]. (PubMed id 21476293)1 Sato K....Shichiri M. (Rinsho Byori 2011)
    8. Serum salusin-alpha level in rheumatoid arthritis. (PubMed id 21185876)1 Ozgen M....Isik A. (Regul. Pept. 2011)
    9. Serum levels and urinary excretion of salusin-alpha in renal insufficiency. (PubMed id 20346378)1 Kimoto S....Shichiri M. (Regul. Pept. 2010)
    10. Chronic infusion of salusin-alpha and -beta exerts opposite effects on atherosclerotic lesion development in apolipoprotein E-deficient mice. (PubMed id 20684826)1 Nagashima M....Hirano T. (Atherosclerosis 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27433 HGNC: 11996 AceView: TTC16 Ensembl:ENSG00000160404 euGenes: HUgn27433
    ECgene: TOR2A H-InvDB: TOR2A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TOR2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TOR2A gene:
    Search GeneIP for patents involving TOR2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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