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Aliases for TOR1AIP2 Gene

Aliases for TOR1AIP2 Gene

  • Torsin 1A Interacting Protein 2 2 3
  • Torsin A Interacting Protein 2 2 3 5
  • 15 KDa Interferon-Responsive Protein 3 4
  • Lumenal Domain-Like LAP1 3 4
  • IFRG15 3 4
  • LULL1 3 4
  • Interferon Responsive Gene 15 3
  • Lumenal Domain Like LAP1 3
  • NET9 3

External Ids for TOR1AIP2 Gene

Previous GeneCards Identifiers for TOR1AIP2 Gene

  • GC01M176546
  • GC01M178075
  • GC01M179809
  • GC01M151044
  • GC01M179884
  • GC01M180102

Summaries for TOR1AIP2 Gene

GeneCards Summary for TOR1AIP2 Gene

TOR1AIP2 (Torsin 1A Interacting Protein 2) is a Protein Coding gene. GO annotations related to this gene include ATPase binding and ATPase activator activity. An important paralog of this gene is TOR1AIP1.

UniProtKB/Swiss-Prot for TOR1AIP2 Gene

  • Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOR1AIP2 Gene

Genomics for TOR1AIP2 Gene

Regulatory Elements for TOR1AIP2 Gene

Promoters for TOR1AIP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TOR1AIP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TOR1AIP2 Gene

Chromosome:
1
Start:
179,839,967 bp from pter
End:
179,877,806 bp from pter
Size:
37,840 bases
Orientation:
Minus strand

Genomic View for TOR1AIP2 Gene

Genes around TOR1AIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOR1AIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOR1AIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOR1AIP2 Gene

Proteins for TOR1AIP2 Gene

  • Protein details for TOR1AIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFQ8-TOIP2_HUMAN
    Recommended name:
    Torsin-1A-interacting protein 2
    Protein Accession:
    Q8NFQ8

    Protein attributes for TOR1AIP2 Gene

    Size:
    470 amino acids
    Molecular mass:
    51263 Da
    Quaternary structure:
    • Interacts with TOR1A and TOR1B (ATP-bound).

    Alternative splice isoforms for TOR1AIP2 Gene

    UniProtKB/Swiss-Prot:
  • Protein details for TOR1AIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H496-IFG15_HUMAN
    Recommended name:
    Torsin-1A-interacting protein 2, isoform IFRG15
    Protein Accession:
    Q9H496
    Secondary Accessions:
    • Q05BU2

    Protein attributes for TOR1AIP2 Gene

    Size:
    131 amino acids
    Molecular mass:
    15348 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH32790.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};

    Alternative splice isoforms for TOR1AIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TOR1AIP2 Gene

Proteomics data for TOR1AIP2 Gene at MOPED

Post-translational modifications for TOR1AIP2 Gene

Other Protein References for TOR1AIP2 Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for TOR1AIP2

No data available for DME Specific Peptides for TOR1AIP2 Gene

Domains & Families for TOR1AIP2 Gene

Protein Domains for TOR1AIP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NFQ8

UniProtKB/Swiss-Prot:

IFG15_HUMAN :
  • Belongs to the TOR1AIP family.
Family:
  • Belongs to the TOR1AIP family.
genes like me logo Genes that share domains with TOR1AIP2: view

No data available for Gene Families for TOR1AIP2 Gene

Function for TOR1AIP2 Gene

Molecular function for TOR1AIP2 Gene

UniProtKB/Swiss-Prot Induction:
Induced by interferon alpha.
UniProtKB/Swiss-Prot Function:
Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity.

Gene Ontology (GO) - Molecular Function for TOR1AIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TOR1AIP2: view
genes like me logo Genes that share phenotypes with TOR1AIP2: view

Animal Model Products

CRISPR Products

miRNA for TOR1AIP2 Gene

miRTarBase miRNAs that target TOR1AIP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TOR1AIP2 Gene

Localization for TOR1AIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOR1AIP2 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TOR1AIP2 Gene COMPARTMENTS Subcellular localization image for TOR1AIP2 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
cytosol 2
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TOR1AIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TOR1AIP2: view

Pathways & Interactions for TOR1AIP2 Gene

SuperPathways for TOR1AIP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TOR1AIP2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TOR1AIP2 Gene

Drugs & Compounds for TOR1AIP2 Gene

No Compound Related Data Available

Transcripts for TOR1AIP2 Gene

Unigene Clusters for TOR1AIP2 Gene

Torsin A interacting protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TOR1AIP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - - -
SP2: - - -
SP3: -
SP4:
SP5: - -

Relevant External Links for TOR1AIP2 Gene

GeneLoc Exon Structure for
TOR1AIP2
ECgene alternative splicing isoforms for
TOR1AIP2

Expression for TOR1AIP2 Gene

mRNA expression in normal human tissues for TOR1AIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TOR1AIP2 Gene

This gene is overexpressed in Bone (13.4) and Breast (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TOR1AIP2 Gene



SOURCE GeneReport for Unigene cluster for TOR1AIP2 Gene Hs.571797

genes like me logo Genes that share expression patterns with TOR1AIP2: view

Protein tissue co-expression partners for TOR1AIP2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TOR1AIP2 Gene

Orthologs for TOR1AIP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TOR1AIP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TOR1AIP2 35
  • 83.98 (n)
  • 76.18 (a)
TOR1AIP2 36
  • 50 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TOR1AIP2 35
  • 84.23 (n)
  • 74.09 (a)
TOR1AIP2 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tor1aip2 35
  • 77.45 (n)
  • 70 (a)
Tor1aip2 16
Tor1aip2 36
  • 63 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TOR1AIP2 35
  • 99.72 (n)
  • 99.36 (a)
TOR1AIP2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tor1aip2 35
  • 76.65 (n)
  • 68.43 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 56 (a)
OneToMany
-- 36
  • 57 (a)
OneToMany
chicken
(Gallus gallus)
Aves TOR1AIP2 36
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TOR1AIP2 36
  • 58 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-82a1.6 36
  • 24 (a)
ManyToMany
zgc:112962 36
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6390 36
  • 21 (a)
OneToMany
Species with no ortholog for TOR1AIP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TOR1AIP2 Gene

ENSEMBL:
Gene Tree for TOR1AIP2 (if available)
TreeFam:
Gene Tree for TOR1AIP2 (if available)

Paralogs for TOR1AIP2 Gene

Paralogs for TOR1AIP2 Gene

(1) SIMAP similar genes for TOR1AIP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TOR1AIP2: view

Variants for TOR1AIP2 Gene

Sequence variations from dbSNP and Humsavar for TOR1AIP2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs9157 -- 179,841,717(+) TATTT(C/T)CTATT utr-variant-3-prime
rs479094 -- 179,872,972(-) attat(A/G)taaga intron-variant
rs589780 -- 179,875,887(-) TATTA(C/T)CATAA intron-variant
rs668813 -- 179,874,156(+) aaaag(G/T)acaaa intron-variant
rs651455 -- 179,872,657(+) TTTTC(C/T)GAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TOR1AIP2 Gene

Variant ID Type Subtype PubMed ID
esv2568232 CNV Deletion 19546169
nsv528201 CNV Loss 19592680
nsv519273 CNV Loss 19592680

Variation tolerance for TOR1AIP2 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.51; 29.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TOR1AIP2 Gene

HapMap Linkage Disequilibrium report
TOR1AIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOR1AIP2 Gene

Disorders for TOR1AIP2 Gene

Relevant External Links for TOR1AIP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TOR1AIP2

No disorders were found for TOR1AIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TOR1AIP2 Gene

Publications for TOR1AIP2 Gene

  1. The AAA+ protein torsinA interacts with a conserved domain present in LAP1 and a novel ER protein. (PMID: 15767459) Goodchild R.E. … Dauer W.T. (J. Cell Biol. 2005) 2 3 4 67
  2. Interaction of torsinA with its major binding partners is impaired by the dystonia-associated DeltaGAG deletion. (PMID: 19651773) Naismith T.V. … Hanson P.I. (J. Biol. Chem. 2009) 3 23
  3. Arresting a Torsin ATPase reshapes the endoplasmic reticulum. (PMID: 24275647) Rose A.E. … Schlieker C. (J. Biol. Chem. 2014) 3
  4. The mechanism of Torsin ATPase activation. (PMID: 25352667) Brown R.S. … Schlieker C. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for TOR1AIP2 Gene

Sources for TOR1AIP2 Gene

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