TOR1A Gene
protein-coding GIFtS: 61
GCID: GC09M132575
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|
torsin family 1, member A (torsin A)(Previous names: dystonia 1, torsion (autosomal dominant; torsin A) )
(Previous symbol: DYT1)
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Aliases
for TOR1A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Torsin Family 1, Member A (Torsin A)1 2 | | Dystonia 1 Protein2 3 | | DYT11 2 3 5 | | Torsin Family 1 Member A2 3 | | DQ21 2 3 | | Torsin-1A1 | | Dystonia 1, Torsion (Autosomal Dominant; Torsin A)1 2 | | |
Export aliases for TOR1A gene to outside databasesPrevious GC identifers: GC09M129655 GC09M131615 GC09M102174 |
Summaries
for TOR1A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TOR1A:
The protein encoded by this gene is a member of the AAA family of adenosine triphosphatases (ATPases), is related tothe Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Mutations inthis gene result in the autosomal dominant disorder, torsion dystonia 1. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TOR1A_HUMAN, O14656Function: May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. Inthe nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and SYNE3, leaving nuclear pores and SUN1 unchanged
Gene Wiki entry for TOR1A (Torsin A)
|
Genomic Views
for TOR1A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TOR1A gene promoter:
Tal-1 p53 Lmo2 CUTL1 AP-2gamma E47 Arnt Roaz AREB6 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for TOR1A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOR1A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34 Ensembl cytogenetic band: 9q34.11 HGNC cytogenetic band: 9q32-q34TOR1A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M132575: view genomic region
(about GC identifiers)
Start:
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132,575,221 bp from pter |
End:
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132,586,441 bp from pter |
Size:
|
11,221 bases |
Orientation:
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minus strand |
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Proteins
for TOR1A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TOR1A_HUMAN, O14656 (See
protein sequence)Recommended Name: Torsin-1A precursor Size: 332 amino acids; 37809 Da
Subunit: May form homohexamers. Interacts with TOR1AIP1 and TOR1AIP2. Interacts with KLHL14, preferentially whenATP-free
Subcellular location: Endoplasmic reticulum lumen. Nucleus membrane. Note=Mainly located in the lumen of theendoplasmic reticulum. The association with nuclear envelope is mediated by the interaction with TOR1AIP2. The Glu-303del variant is lumenally-oriented in discrete large spheroid intracellular structures rather than in the endoplasmicreticulum
Secondary accessions: B2RB58 Q53Y64 Q96CA0Alternative splicing: 2 isoforms: O14656-1 O14656-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TOR1A: NX_O14656
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O14656
TOR1A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000104.1
ENSEMBL proteins: ENSP00000345719
Human Recombinant Protein Products for TOR1A:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
TOR1A for ontologies About GeneDecksing
TOR1A Antibody Products:
Assay Products for TOR1A: |
Protein
Domains /
Families
for TOR1A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TOR1A for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O14656ProtoNet protein and cluster: O14656 1 Blocks protein family: IPB010448 Torsin
UniProtKB/Swiss-Prot: TOR1A_HUMAN, O14656Similarity: Belongs to the clpA/clpB family. Torsin subfamily |
Function
for TOR1A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TOR1A_HUMAN, O14656Function: May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. Inthe nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and SYNE3, leaving nuclear pores and SUN1 unchanged Genatlas biochemistry entry for TOR1A:torsin 1A ATP binding protein,homolog to TOR1B,expressed in adult brain substantia nigra,hippocampus,frontalcortex,homolog to heat shock proteins and C1p proteases
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
TOR1A for ontologies About GeneDecksing
Phenotypes:
5 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Tor1a):
TOR1A for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for TOR1A: Tor1atm2.1Yql Tor1atm1Wtd
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOR1A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOR1A (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TOR1A (NM_000113) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TOR1A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOR1A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOR1A |
|
Pathways & Interactions
for TOR1A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cytoskeletal Signaling | | | 2 | Alpha-synuclein signaling | | | 3 | Neuroscience | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Cell Signaling Technology (CST) Pathways for TOR1A
1  BioSystems Pathway for TOR1A
TOR1A for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TOR1A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/14 Interacting proteins for TOR1A (O146562, 3 ENSP000003457194) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
TOR1A for ontologies About GeneDecksing
|
Drugs & Compounds
for TOR1A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TOR1A for compounds About GeneDecksing
 Browse Tocris compounds for TOR1A
4 Novoseek chemical compound relationships for TOR1A gene About this table
Search CenterWatch for drugs/clinical trials and news about TOR1A
|
Transcripts
for TOR1A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TOR1A gene: NM_000113.2 Unigene Cluster for TOR1A: Torsin family 1, member A (torsin A) Hs.534312 [show with all ESTs]Unigene Representative Sequence: NM_0001134 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000351698(uc004byl.3) ENST00000474192 ENST00000473604 ENST00000473084(uc004byn.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOR1A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOR1A (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TOR1A (NM_000113) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TOR1A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOR1A |
Additional cDNA sequence: AF007871.1 AK056062.1 AK075343.1 AK130769.1 AK294677.1 AK314505.1 BC000674.2 BC014484.1 BT006931.1 10 DOTS entries: DT.87017237 DT.100821060 DT.95242375 DT.91755233 DT.100821070 DT.95132482 DT.40123373 DT.100821057 DT.100821061 DT.91755231 24/279 AceView cDNA sequences (see all 279): BM759836 BM464643 CR623187 BC014484 CA942174 CR602179 AA614414 AA766539 AW305016 AA767261 CB996059 BM927216 CF593682 CR622117 AA312679 CA412462 BU538028 BI195565 BX412626 CD105750 BG469813 BU617002 AA593777 BM924465
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TOR1A (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c |
|---|
|
| SP1: | | | | | - | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TOR1A
|
Expression
for TOR1A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TOR1A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCCAAAAAA
About this image
See TOR1A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TOR1A
SOURCE GeneReport for Unigene cluster: Hs.534312
UniProtKB/Swiss-Prot: TOR1A_HUMAN, O14656Tissue specificity: Widely expressed. Highest levels in kidney and liver. Not detected in spleen. In the brain, highlevels found in the dopaminergic neurons of the substantia nigra pars compacta, as well as in the neocortex,hippocampus and cerebellum. Also high expression in the spinal cord
SABiosciences Expression via Pathway-Focused PCR Arrays including TOR1A:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOR1A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TOR1A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOR1A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOR1A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOR1A |
Orthologs
for TOR1A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TOR1A gene from 5/22 species (see all 22) About this table
ENSEMBL Gene Tree for TOR1A (if available)
TreeFam Gene Tree for TOR1A (if available) |
Paralogs
for TOR1A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TOR1A gene
- TOR2A2 TOR4A2 TOR1B2 TOR3A2
3 SIMAP similar genes for TOR1A using alignment to 2 protein entries: TOR1A_HUMAN (see all proteins):TOR1B TOR2A TOR3A
TOR1A for paralogs About GeneDecksing
|
Genomic Variants
for TOR1A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TOR1A (132575221 - 132586441 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TOR1A: --
Human Gene Mutation Database (HGMD): TOR1A
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOR1A |
|
Disorders
/ Diseases
for TOR1A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TOR1A for disorders About GeneDecksing
OMIM gene information: 605204
OMIM disorders: 128100
UniProtKB/Swiss-Prot: TOR1A_HUMAN, O14656
Defects in TOR1A are the cause of dystonia type 1 (DYT1) [MIM:128100]. DYT1 is a primary torsion dystonia, andthe most common and severe form. Dystonia is defined by the presence of sustained involuntary muscle contractions,often leading to abnormal postures. DYT1 is characterized by involuntary, repetitive, sustained muscle contractions orpostures involving one or more sites of the body, in the absence of other neurological symptoms. Typically, symptomsdevelop first in an arm or leg in middle to late childhood and progress in approximately 30% of patients to other bodyregions (generalized dystonia) within about five years. 'Torsion' refers to the twisting nature of body movementsobserved in DYT1, often affecting the trunk. Distribution and severity of symptoms vary widely between affectedindividuals, ranging from mild focal dystonia to severe generalized dystonia, even within families
20/30  diseases for TOR1A (see all 30): About MalaCardsdystonia 1 torsion dystonia dystonia, early-onset atypical, with myoclonic features early-onset primary dystonia (dyt1)
rapid-onset dystonia-parkinsonism dystonia-1, modifier of dystonia musculorum deformans spasmodic dysphonia
obsessive-compulsive disorder myoclonus-dystonia focal dystonia limb dystonia
blepharospasm child syndrome cerebral palsy familial dystonia
myoclonus acanthocytosis herpes simplex tourette syndrome
3 diseases from the University of Copenhagen DISEASES database for TOR1A:Familial dystonia Movement disease Eyelid disease 10/15 Novoseek disease relationships for TOR1A gene (see all 15) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| torsion dystonia |
98.3 |
92 |
19038309 (3), 9585364 (3), 11277585 (2), 10644435 (2) (see all 63) |
| dystonia primary |
96.9 |
46 |
16631205 (4), 19344776 (3), 11921134 (3), 16198613 (3) (see all 25) |
| secondary dystonia |
90.3 |
3 |
9191768 (1), 9750907 (1), 11948764 (1) |
| focal dystonia |
88.6 |
11 |
9837831 (3), 11087801 (1), 15726581 (1), 14581671 (1) (see all 7) |
| dystonias sporadic |
88.1 |
1 |
16631205 (1) |
| movement disorders |
86.1 |
15 |
14872019 (2), 12360559 (1), 16830314 (1), 12402271 (1) (see all 12) |
| myoclonic dystonia |
85.1 |
1 |
16227522 (1) |
| blepharospasm |
63.2 |
3 |
19202559 (2), 17133500 (1) |
| early disease onset |
61.8 |
1 |
19457118 (1) |
| cerebral palsy |
33.8 |
2 |
15996397 (1) |
GeneTests: TOR1A
Early-Onset Primary Dystonia (DYT1)
Genetic Association Database (GAD): TOR1A
Human Genome Epidemiology (HuGE) Navigator: TOR1A (25 documents)
Export disorders for TOR1A gene to outside databases
|
Publications
for TOR1A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TOR1A gene, integrated from 9 sources (see all 226):
(articles sorted by number of sources associating them with TOR1A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Torsin A and its torsion dystonia-associated mutant forms are lumenal glycoproteins that exhibit distinct subcellular localizations. (PubMed id 10871631)1, 2, 9 Kustedjo K.... Cravatt B.F. (2000)
- Mutations in DYT1: extension of the phenotypic and mutational spectrum. (PubMed id 14872019)1, 4, 9 Kabakci K....Klein C. (2004)
- Frequency and phenotypic variability of the GAG deletion of the DYT1 gene in an unselected group of patients with dystonia. (PubMed id 12975293)1, 4, 9 Grundmann K....Riess O. (2003)
- The TOR1A (DYT1) gene family and its role in early onset torsion dystonia. (PubMed id 10644435)1, 3, 9 Ozelius L.J....Breakefield X.O. (1999)
- DYT1 mutation in Korean primary dystonia patients. (PubMed id 15465399)1, 4, 9 Im J.H....Jeon B.S. (2004)
- DYT1 mutation in a cohort of Taiwanese primary dystonias. (PubMed id 16198613)1, 4, 9 Lin Y.W....Lu C.S. (2006)
- Frequency of DYT1 mutation in early onset primary dystonia in Italian patients. (PubMed id 11921134)1, 4, 9 Zorzi G....Nardocci N. (2002)
- Microstructural white matter changes in carriers of the DYT1 gene mutation. (PubMed id 15293281)1, 4, 9 Carbon M....Eidelberg D. (2004)
- Candidate gene studies in focal dystonia. (PubMed id 14581671)1, 4, 9 Sibbing D....Bandmann O. (2003)
- The early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein. (PubMed id 9288096)1, 2, 9 Ozelius L.J.... Breakefield X.O. (1997)
|
External Searches for TOR1A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TOR1A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TOR1A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TOR1A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TOR1A | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TOR1A |
|
| | |
About This Section
| Patent Information for TOR1A gene:
Search GeneIP for patents involving TOR1A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TOR1A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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| | |  | OriGene Antibodies for TOR1A | | OriGene shRNA RFP for TOR1A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TOR1A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOR1A | | | OriGene Protein Over-expression Lysate for TOR1A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TOR1A | | OriGene 3'-UTR Clone for TOR1A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOR1A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOR1A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TOR1A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TOR1A | | OriGene Custom Protein Services for TOR1A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TOR1A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOR1A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOR1A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOR1A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOR1A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOR1A |
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| | Antibodies & Assays for TOR1A |
| | | | Search Tocris compounds for TOR1A |
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 | | | TOR1A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOR1A |
|  |  |  |  | | | | ThermoFisher Antibodies for TOR1A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOR1A |
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