TOPORS Gene
protein-coding GIFtS: 55
GCID: GC09M032496
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|
topoisomerase I binding, arginine/serine-rich, E3 ubiquitin...(Previous names: retinitis pigmentosa 31 (autosomal dominant), topoisomerase...)
(Previous symbol: RP31)
| |
Aliases
for TOPORS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Topoisomerase I Binding, Arginine/Serine-Rich, E3 Ubiquitin ProteinLigase1 2 | | Retinitis Pigmentosa 31 (Autosomal Dominant)1 | | LUN1 2 3 5 | | Topoisomerase I Binding, Arginine/Serine-Rich1 | | TP53BPL1 2 3 | | E3 Ubiquitin-Protein Ligase Topors2 | | RP311 2 5 | | EC 6.3.2.-3 | | Topoisomerase I-Binding RING Finger Protein2 3 | | P53-Binding Protein 33 | | Tumor Suppressor P53-Binding Protein 32 3 | | P53BP32 5 | | SUMO1-Protein E3 Ligase Topors2 3 | | Topoisomerase I-Binding Arginine/Serine-Rich Protein3 | | P53BP32 5 | | |
Export aliases for TOPORS gene to outside databasesPrevious GC identifer: GC09M032530 |
Summaries
for TOPORS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TOPORS:
This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. Itis highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene areassociated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms,have been observed for this locus. (provided by RefSeq, Sep 2010)
UniProtKB/Swiss-Prot: TOPRS_HUMAN, Q9NS56Function: Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressorinvolved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability throughubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatinmodification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation
Gene Wiki entry for TOPORS
|
Genomic Views
for TOPORS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TOPORS gene promoter:
AML1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for TOPORS
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOPORS |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p21 Ensembl cytogenetic band: 9p21.1 HGNC cytogenetic band: 9p21TOPORS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M032496: view genomic region
(about GC identifiers)
Start:
|
32,540,542 bp from pter |
End:
|
32,552,622 bp from pter |
Size:
|
12,081 bases |
Orientation:
|
minus strand |
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Proteins
for TOPORS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TOPRS_HUMAN, Q9NS56 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase Topors Size: 1045 amino acids; 119198 Da
Subunit: Interacts with PARK7/DJ-1 (By similarity). Interacts with TOP1. Interacts with p53/TP53; can both ubiquitinateand sumoylate p53/TP53. Interacts with the SUMO1 conjugating enzyme UBE2I. Interacts with SUMO1. Interacts withNKX3-1; polyubiquitinates NKX3-1 and induces its proteasomal degradation. Interacts with SIN3A; sumoylates SIN3A.Interacts with IKBKE; induced by DNA damage
Subcellular location: Nucleus. Nucleus, PML body. Note=Localizes to discrete nuclear foci which partly overlap with PMLnuclear bodies. Targeted to PML nuclear bodies upon DNA damage
Caution: Was originally (PubMed:11278651) thought to bind to the palindromic consensus sequence 5'-TCCCAGCACTTTGGGA-3'and to regulate the transcription of numerous genes in the lung
Sequence caution: Sequence=AAC98530.1; Type=Erroneous initiation;
Secondary accessions: O43273 Q6P987 Q9NS55 Q9UNR9Alternative splicing: 2 isoforms: Q9NS56-1 Q9NS56-2 Explore the universe of human proteins at neXtProt for TOPORS: NX_Q9NS56
Post-translational modifications:
Phosphorylation at Ser-98 regulates the E3 ubiquitin-protein ligase activity but not the SUMO1-protein ligase activity.Phosphorylation at Ser-718 increases the E3 ubiquitin-protein ligase activity versus the SUMO1-protein ligase activityresulting in increased p53/TP53 ubiquitination and degradation1
Sumoylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NS56
TOPORS Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001182551.1 NP_005793.2
ENSEMBL proteins: ENSP00000353735 ENSP00000369187
Human Recombinant Protein Products for TOPORS:
Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table
TOPORS for ontologies About GeneDecksing
TOPORS Antibody Products:
Assay Products for TOPORS: |
Protein
Domains /
Families
for TOPORS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TOPORS for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NS56ProtoNet protein and cluster: Q9NS56 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: TOPRS_HUMAN, Q9NS56Similarity: Contains 1 RING-type zinc finger |
Function
for TOPORS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TOPRS_HUMAN, Q9NS56Function: Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressorinvolved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability throughubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatinmodification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylationInduction: By genotoxic agents such as cisplatin and camptothecin Enzyme Number (IUBMB): EC 6.3.2.-1
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
TOPORS for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for TOPORS:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOPORS (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOPORS (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TOPORS (NM_005802) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TOPORS | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOPORS |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOPORS |
|
Pathways & Interactions
for TOPORS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TOPORS
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/46 Interacting proteins for TOPORS (Q9NS562, 3 ENSP000003537354) via UniProtKB, MINT, STRING, and/or I2D (see all 46)About this table
Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20): About this table
TOPORS for ontologies About GeneDecksing
|
Drugs & Compounds
for TOPORS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TOPORS for compounds About GeneDecksing
 Browse Tocris compounds for TOPORS
4 HMDB Compounds for TOPORS About this table
1 Novoseek chemical compound relationship for TOPORS gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| camptothecin |
53.3 |
2 |
15735665 (1), 9512561 (1) |
Search CenterWatch for drugs/clinical trials and news about TOPORS / TOPRS
|
Transcripts
for TOPORS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TOPORS gene (2 alternative transcripts): NM_001195622.1 NM_005802.4 Unigene Cluster for TOPORS: Topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase Hs.589962 [show with all ESTs]Unigene Representative Sequence: NM_0058022 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000360538(uc003zrb.3 uc003zrc.3) ENST00000379858
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOPORS (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOPORS (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TOPORS (NM_005802) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TOPORS | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOPORS |
Additional cDNA sequence: AB045732.1 AB045733.1 AF098300.1 BC060884.1 U82939.1 8 DOTS entries: DT.311821 DT.100748176 DT.121195797 DT.121195885 DT.91819669 DT.97779026 DT.100690322 DT.95337894 24/185 AceView cDNA sequences (see all 185): AA292388 AI520921 CD299987 AI873664 AA679829 CB150537 AA251880 AV645481 AW206733 AK125989 AU139094 BM825879 AA126958 AA626115 CB118537 BF055055 AA506435 AI801182 BM837370 AI350993 BX647917 BM669635 AV645468 NM_005802
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for TOPORS About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c |
|---|
|
| SP1: | | | | | - | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TOPORS
|
Expression
for TOPORS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TOPORS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAAACCCTT
About this image
See TOPORS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TOPORS
SOURCE GeneReport for Unigene cluster: Hs.589962
UniProtKB/Swiss-Prot: TOPRS_HUMAN, Q9NS56Tissue specificity: Expressed at highest levels in testis and at lower levels in adrenal gland, bone marrow, brain,colon, heart, kidney, liver, muscle, ovary, pancreas, placenta, prostate, skeletal muscle, skin, small intestine,spleen, stomach, testis, thymus, thyroid and uterus. Expressed in the alveolar epithelium of the lung. Expression iscommonly decreased in colon adenocarcinomas and lung cancers
SABiosciences Expression via Pathway-Focused PCR Array including TOPORS:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOPORS
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TOPORS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOPORS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOPORS | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOPORS |
Orthologs
for TOPORS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TOPORS gene from 7/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Topors1 , 5 |
topoisomerase I binding, arginine/serine-rich1, 5 |
86.25(n)1
87.38(a)1 |
|
4 (20.24 cM)5
1060211 NM_134097.31 NP_598858.21
402596015 |
chicken
(Gallus gallus) |
Aves |
TOPORS1 |
topoisomerase I binding, arginine/serine-rich |
63.36(n)
60.86(a) |
|
427342 XM_424920.3 XP_424920.3 |
lizard
(Anolis carolinensis) |
Reptilia |
---- |
-- |
52(a)47(a) |
many → 1many → 1 |
GL343463.1(57815-60328) GL343497.1(162862-163769) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.44182 |
Transcribed sequence with weak similarity to protein more |
76.26(n) |
|
AL889310.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufi75f042 |
Transcribed sequence with weak similarity to protein more |
70.31(n) |
|
57069658 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Topors6 |
Topoisomerase I-interacting protein |
16(a) |
1 ↔ 1 |
2R(14860117-14864767) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT2G391006 |
RING/U-box domain-containing protein |
21(a) |
1 ↔ 1 |
2(16317438-16319387) |
ENSEMBL Gene Tree for TOPORS (if available)
TreeFam Gene Tree for TOPORS (if available) |
Paralogs
for TOPORS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TOPORS gene
TOPORS for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TOPORS
PGOHUM00000236741
|
Genomic Variants
for TOPORS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TOPORS (32540542 - 32552622 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TOPORS
2 CNVs: 95932 95931
Human Gene Mutation Database (HGMD): TOPORS
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOPORS |
|
Disorders
/ Diseases
for TOPORS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TOPORS for disorders About GeneDecksing
OMIM gene information: 609507
OMIM disorders: 609923
UniProtKB/Swiss-Prot: TOPRS_HUMAN, Q9NS56
Defects in TOPORS are the cause of retinitis pigmentosa type 31 (RP31) [MIM:609923]. RP leads to degenerationof retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field.As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP31inheritance is autosomal dominant
13  diseases for TOPORS: About MalaCardsretinitis pigmentosa retinitis pigmentosa 31 retinitis rift valley fever
dna topoisomerase i retinal degeneration colon adenocarcinoma blindness
lung cancer adenocarcinoma leukemia thyroiditis
prostatitis
2 Novoseek disease relationships for TOPORS gene About this table
Human Genome Epidemiology (HuGE) Navigator: TOPORS (2 documents)
Export disorders for TOPORS gene to outside databases
|
Publications
for TOPORS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TOPORS gene, integrated from 9 sources (see all 61):
(articles sorted by number of sources associating them with TOPORS) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mutations in TOPORS cause autosomal dominant retinitis pigmentosa with perivascular retinal pigment epithelium atrophy. (PubMed id 17924349)1, 2, 3, 9 Chakarova C.F.... Bhattacharya S.S. (2007)
- Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein. (PubMed id 10352183)1, 2, 3, 9 Haluska P. Jr....Rubin E.H. (1999)
- The topoisomerase I-binding RING protein, topors, is associated with promyelocytic leukemia nuclear bodies. (PubMed id 12083797)1, 2, 3 Rasheed Z.A....Rubin E.H. (2002)
- Topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage. (PubMed id 15735665)1, 2, 9 Lin L.... Koseki H. (2005)
- The topoisomerase I- and p53-binding protein topors is differentially expressed in normal and malignant human tissues and may function as a tumor suppressor. (PubMed id 15107820)1, 2, 9 Saleem A.... Rubin E.H. (2004)
- Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1. (PubMed id 18077445)1, 2, 9 Guan B....Bieberich C.J. (2008)
- Plk1-mediated phosphorylation of Topors regulates p53 stability. (PubMed id 19473992)1, 2, 9 Yang X....Liu X. (2009)
- Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo. (PubMed id 16122737)1, 2, 9 Weger S.... Heilbronn R. (2005)
- Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53. (PubMed id 15247280)1, 2, 9 Rajendra R.... Rubin E.H. (2004)
- SUMOylation-dependent localization of IKKepsilon in P ML nuclear bodies is essential for protection against DNA-damage-triggered cell death. (PubMed id 20188669)1, 2 Renner F....Schmitz M.L. (2010)
|
External Searches for TOPORS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TOPORS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TOPORS gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TOPORS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TOPORS gene:
Search GeneIP for patents involving TOPORS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TOPORS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TOPORS | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TOPORS | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOPORS | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TOPORS | | OriGene 3'-UTR Clone for TOPORS | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOPORS | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOPORS | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TOPORS | | OriGene Custom Protein Services for TOPORS | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TOPORS | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOPORS | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOPORS | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOPORS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOPORS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOPORS |
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| | | | Search Tocris compounds for TOPORS |
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 | | | TOPORS Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOPORS |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TOPORS |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOPORS |
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