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Aliases for TOPAZ1 Gene

Aliases for TOPAZ1 Gene

  • Testis And Ovary Specific PAZ Domain Containing 1 2 3
  • C3orf77 3 4
  • Testis- And Ovary-Specific PAZ Domain-Containing Protein 1 3
  • Testis And Ovary-Specific PAZ Domain Gene 1 3
  • Chromosome 3 Open Reading Frame 77 2
  • C3orf77, 6
  • Topaz 1 3

External Ids for TOPAZ1 Gene

Previous Symbols for TOPAZ1 Gene

  • C3orf77

Summaries for TOPAZ1 Gene

GeneCards Summary for TOPAZ1 Gene

TOPAZ1 (Testis And Ovary Specific PAZ Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOPAZ1 Gene

Genomics for TOPAZ1 Gene

Genomic Location for TOPAZ1 Gene

Start:
44,241,886 bp from pter
End:
44,332,098 bp from pter
Size:
90,213 bases
Orientation:
Plus strand

Genomic View for TOPAZ1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TOPAZ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOPAZ1 Gene

No data available for Regulatory Elements for TOPAZ1 Gene

Proteins for TOPAZ1 Gene

  • Protein details for TOPAZ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9V7-TOPZ1_HUMAN
    Recommended name:
    Testis- and ovary-specific PAZ domain-containing protein 1
    Protein Accession:
    Q8N9V7
    Secondary Accessions:

    Protein attributes for TOPAZ1 Gene

    Size:
    1692 amino acids
    Molecular mass:
    190927 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TOPAZ1 Gene

Proteomics data for TOPAZ1 Gene at MOPED

Post-translational modifications for TOPAZ1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TOPAZ1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TOPAZ1 Gene

Domains for TOPAZ1 Gene

Protein Domains for TOPAZ1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TOPZ1_HUMAN
Similarity:
  • Contains 1 C3H1-type zinc finger.:
    • Q8N9V7
genes like me logo Genes that share domains with TOPAZ1: view

No data available for Gene Families for TOPAZ1 Gene

Function for TOPAZ1 Gene

Gene Ontology (GO) - Molecular Function for TOPAZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TOPAZ1: view

Phenotypes for TOPAZ1 Gene

genes like me logo Genes that share phenotypes with TOPAZ1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TOPAZ1 Gene

Localization for TOPAZ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOPAZ1 Gene

Cytoplasm, cytosol.

Gene Ontology (GO) - Cellular Components for TOPAZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with TOPAZ1: view

Pathways for TOPAZ1 Gene

SuperPathways for TOPAZ1 Gene

No Data Available

Interacting Proteins for TOPAZ1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000310303%0d%0a9606.ENSP00000384490%0d%0a
Selected Interacting proteins: ENSP00000310303 Q8N9V7-TOPZ1_HUMAN for TOPAZ1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TOPAZ1 Gene

None

No data available for Pathways by source for TOPAZ1 Gene

Transcripts for TOPAZ1 Gene

mRNA/cDNA for TOPAZ1 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TOPAZ1 Gene

Testis and ovary specific PAZ domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TOPAZ1 Gene

No ASD Table

Relevant External Links for TOPAZ1 Gene

GeneLoc Exon Structure for
TOPAZ1
ECgene alternative splicing isoforms for
TOPAZ1

Expression for TOPAZ1 Gene

mRNA expression in normal human tissues for TOPAZ1 Gene

mRNA differential expression in normal tissues according to GTEx for TOPAZ1 Gene

This gene is overexpressed in Testis (48.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TOPAZ1 Gene

SOURCE GeneReport for Unigene cluster for TOPAZ1 Gene Hs.132125

genes like me logo Genes that share expressions with TOPAZ1: view

Orthologs for TOPAZ1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TOPAZ1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOPAZ1 36
  • 99.51 (n)
  • 99.05 (a)
TOPAZ1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TOPAZ1 36
  • 85.61 (n)
  • 78.32 (a)
TOPAZ1 37
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TOPAZ1 36
  • 88.48 (n)
  • 80.77 (a)
TOPAZ1 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Topaz1 36
  • 78.85 (n)
  • 68.52 (a)
Topaz1 16
Topaz1 37
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TOPAZ1 37
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TOPAZ1 37
  • 30 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Topaz1 36
  • 78.22 (n)
  • 68.78 (a)
chicken
(Gallus gallus)
Aves TOPAZ1 36
  • 55.62 (n)
  • 42.97 (a)
TOPAZ1 37
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TOPAZ1 37
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10401 36
tropical clawed frog
(Silurana tropicalis)
Amphibia topaz1 36
  • 62.26 (n)
  • 55.82 (a)
Species with no ortholog for TOPAZ1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TOPAZ1 Gene

ENSEMBL:
Gene Tree for TOPAZ1 (if available)
TreeFam:
Gene Tree for TOPAZ1 (if available)

Paralogs for TOPAZ1 Gene

No data available for Paralogs for TOPAZ1 Gene

Variants for TOPAZ1 Gene

Sequence variations from dbSNP and Humsavar for TOPAZ1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs996763 -- 44,280,950(-) ACAAA(C/T)TCCTC intron-variant
rs996764 -- 44,280,846(-) GCCCA(A/G)TGGAA intron-variant
rs1124124 -- 44,261,053(-) TTTAA(A/T)ATTTT intron-variant
rs1124125 -- 44,260,980(-) CAAAA(A/G)AAAAG intron-variant
rs1352430 -- 44,263,991(+) CAAAT(A/G)CCTTT intron-variant

Relevant External Links for TOPAZ1 Gene

HapMap Linkage Disequilibrium report
TOPAZ1

No data available for Structural Variations from Database of Genomic Variants (DGV) for TOPAZ1 Gene

Disorders for TOPAZ1 Gene

No disorders were found for TOPAZ1 Gene.

No data available for UniProtKB/Swiss-Prot for TOPAZ1 Gene

Publications for TOPAZ1 Gene

  1. TOPAZ1, a novel germ cell-specific expressed gene conserved during evolution across vertebrates. (PMID: 22069478) Baillet A. … Mandon-PAcpin B. (PLoS ONE 2011) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PMID: 21282530) Vandamme J. … Angrand P.O. (Mol. Cell. Proteomics 2011) 3
  4. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for TOPAZ1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TOPAZ1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TOPAZ1
    • Block miRNA regulation of TOPAZ1 using miScript Target Protectors

    Sources for TOPAZ1 Gene

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