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Aliases for TOPAZ1 Gene

Aliases for TOPAZ1 Gene

  • Testis And Ovary Specific PAZ Domain Containing 1 2 3 5
  • C3orf77 3 4
  • Testis And Ovary-Specific PAZ Domain Gene 1 3
  • Chromosome 3 Open Reading Frame 77 2
  • Topaz 1 3

External Ids for TOPAZ1 Gene

Previous HGNC Symbols for TOPAZ1 Gene

  • C3orf77

Summaries for TOPAZ1 Gene

GeneCards Summary for TOPAZ1 Gene

TOPAZ1 (Testis And Ovary Specific PAZ Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOPAZ1 Gene

Genomics for TOPAZ1 Gene

Genomic Location for TOPAZ1 Gene

44,241,886 bp from pter
44,336,610 bp from pter
94,725 bases
Plus strand

Genomic View for TOPAZ1 Gene

Genes around TOPAZ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOPAZ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOPAZ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOPAZ1 Gene

No data available for Regulatory Elements for TOPAZ1 Gene

Proteins for TOPAZ1 Gene

  • Protein details for TOPAZ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis- and ovary-specific PAZ domain-containing protein 1
    Protein Accession:

    Protein attributes for TOPAZ1 Gene

    1692 amino acids
    Molecular mass:
    190927 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TOPAZ1 Gene

Proteomics data for TOPAZ1 Gene at MOPED

Post-translational modifications for TOPAZ1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TOPAZ1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TOPAZ1 Gene

Domains & Families for TOPAZ1 Gene

Protein Domains for TOPAZ1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C3H1-type zinc finger.
  • Contains 1 C3H1-type zinc finger.
genes like me logo Genes that share domains with TOPAZ1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for TOPAZ1 Gene

Function for TOPAZ1 Gene

genes like me logo Genes that share phenotypes with TOPAZ1: view

Animal Models for TOPAZ1 Gene

MGI Knock Outs for TOPAZ1:

Animal Model Products

miRNA for TOPAZ1 Gene

miRTarBase miRNAs that target TOPAZ1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TOPAZ1 Gene

Localization for TOPAZ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOPAZ1 Gene

Cytoplasm, cytosol.

Subcellular locations from

Jensen Localization Image for TOPAZ1 Gene COMPARTMENTS Subcellular localization image for TOPAZ1 gene
Compartment Confidence
cytosol 4
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for TOPAZ1 Gene

Pathways & Interactions for TOPAZ1 Gene

SuperPathways for TOPAZ1 Gene

No Data Available

Interacting Proteins for TOPAZ1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q8N9V7-TOPZ1_HUMAN ENSP00000310303 for TOPAZ1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for TOPAZ1 Gene


No data available for Pathways by source and SIGNOR curated interactions for TOPAZ1 Gene

Drugs & Compounds for TOPAZ1 Gene

No Compound Related Data Available

Transcripts for TOPAZ1 Gene

mRNA/cDNA for TOPAZ1 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TOPAZ1 Gene

Testis and ovary specific PAZ domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TOPAZ1 Gene

No ASD Table

Relevant External Links for TOPAZ1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TOPAZ1 Gene

mRNA expression in normal human tissues for TOPAZ1 Gene

mRNA differential expression in normal tissues according to GTEx for TOPAZ1 Gene

This gene is overexpressed in Testis (x48.6).

Protein differential expression in normal tissues from HIPED for TOPAZ1 Gene

This gene is overexpressed in Nasal epithelium (51.9) and Cerebrospinal fluid (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TOPAZ1 Gene

SOURCE GeneReport for Unigene cluster for TOPAZ1 Gene Hs.132125

genes like me logo Genes that share expression patterns with TOPAZ1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TOPAZ1 Gene

Orthologs for TOPAZ1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TOPAZ1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TOPAZ1 35
  • 85.61 (n)
  • 78.32 (a)
  • 77 (a)
(Canis familiaris)
Mammalia TOPAZ1 35
  • 88.48 (n)
  • 80.77 (a)
  • 80 (a)
(Mus musculus)
Mammalia Topaz1 35
  • 78.85 (n)
  • 68.52 (a)
Topaz1 16
Topaz1 36
  • 68 (a)
(Pan troglodytes)
Mammalia TOPAZ1 35
  • 99.51 (n)
  • 99.05 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Topaz1 35
  • 78.22 (n)
  • 68.78 (a)
(Monodelphis domestica)
Mammalia TOPAZ1 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia TOPAZ1 36
  • 30 (a)
(Gallus gallus)
Aves TOPAZ1 35
  • 55.62 (n)
  • 42.97 (a)
  • 44 (a)
(Anolis carolinensis)
Reptilia TOPAZ1 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia topaz1 35
  • 62.26 (n)
  • 55.82 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10401 35
Species with no ortholog for TOPAZ1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TOPAZ1 Gene

Gene Tree for TOPAZ1 (if available)
Gene Tree for TOPAZ1 (if available)

Paralogs for TOPAZ1 Gene

No data available for Paralogs for TOPAZ1 Gene

Variants for TOPAZ1 Gene

Sequence variations from dbSNP and Humsavar for TOPAZ1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs9833423 - 44,242,180(+) GGGGG(C/G/T)GCCGG reference, missense
rs7645375 - 44,242,316(+) GGGCC(A/C)GGTGA reference, missense
rs9284879 - 44,243,092(+) TTAAG(A/G)TTGAA reference, missense
rs17076541 - 44,243,954(+) CTGTC(A/G)GAGAA reference, missense
rs17646517 - 44,244,523(+) TAGTT(C/G)CAGAC reference, missense

Variation tolerance for TOPAZ1 Gene

Gene Damage Index Score: 4.68; 65.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TOPAZ1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TOPAZ1 Gene

Disorders for TOPAZ1 Gene

Relevant External Links for TOPAZ1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TOPAZ1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TOPAZ1 Gene

Publications for TOPAZ1 Gene

  1. TOPAZ1, a novel germ cell-specific expressed gene conserved during evolution across vertebrates. (PMID: 22069478) Baillet A. … Mandon-PAcpin B. (PLoS ONE 2011) 2 3 67
  2. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 3
  3. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PMID: 21282530) Vandamme J. … Angrand P.O. (Mol. Cell. Proteomics 2011) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for TOPAZ1 Gene

Sources for TOPAZ1 Gene

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