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Aliases for TOP3BP1 Gene

Aliases for TOP3BP1 Gene

  • Topoisomerase (DNA) III Beta Pseudogene 1 2 3 5
  • Topoisomerase (DNA) III Beta, 2 2 3
  • TOP3B2 3

External Ids for TOP3BP1 Gene

Previous HGNC Symbols for TOP3BP1 Gene

  • TOP3B2

Previous GeneCards Identifiers for TOP3BP1 Gene

  • GC22M022582

Summaries for TOP3BP1 Gene

Entrez Gene Summary for TOP3BP1 Gene

  • This gene was predicted by automated computational analysis. It encodes a protein with similarity to human topoisomerase (DNA) III beta, which is thought to relax supercoiled DNA upon replication, transcription, and cell division. This gene lies in the immunoglobulin lambda gene cluster on chromosome 22q11.21. [provided by RefSeq, Jul 2008]

GeneCards Summary for TOP3BP1 Gene

TOP3BP1 (Topoisomerase (DNA) III Beta Pseudogene 1) is a Pseudogene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOP3BP1 Gene

Genomics for TOP3BP1 Gene

Regulatory Elements for TOP3BP1 Gene

Enhancers for TOP3BP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F021936 1.5 FANTOM5 ENCODE 56 +279.8 279819 17.5 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ENSG00000224086 TOP3BP1 TOP3B IGLV5-52 THAP7 THAP7-AS1 ENSG00000234630 ENSG00000272779 PPM1F PPIL2
GH22F021864 1.4 FANTOM5 ENCODE 19.8 +357.4 357442 4.3 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 ENSG00000224086 TOP3BP1 IGLV5-52 MAPK1 SDF2L1 HIC2 RNA5SP493
GH22F021834 1.2 Ensembl ENCODE 16.3 +387.6 387566 5.2 PKNOX1 ATF1 INSM2 ZNF366 SCRT2 ETV6 KLF13 EGR2 ZNF263 ZNF362 ENSG00000224086 TOP3BP1 PPM1F PI4KAP2 MAPK1 RNA5SP493
GH22F021753 1.2 Ensembl ENCODE 14.9 +468.1 468119 6.5 PKNOX1 ZFP64 FEZF1 ZNF2 RAD21 ZNF121 GLIS2 ZNF143 FOS KDM4B ENSG00000224086 TOP3BP1 IGLV5-52 THAP7-AS1 THAP7 PPM1F ENSG00000272779 YPEL1 RNA5SP493
GH22F021813 1.7 FANTOM5 Ensembl ENCODE 8.2 +407.5 407466 7.4 PKNOX1 ARNT CREB3L1 SIN3A CBX5 GATA2 ZNF207 FOS KLF13 KDM4B ENSG00000224086 PPM1F IGLV5-52 YPEL1 THAP7-AS1 THAP7 ENSG00000272779 TOP3BP1 MAPK1 HIC2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TOP3BP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TOP3BP1 Gene

22,223,186 bp from pter
22,224,566 bp from pter
1,381 bases
Minus strand

Genomic View for TOP3BP1 Gene

Genes around TOP3BP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOP3BP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOP3BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOP3BP1 Gene

Proteins for TOP3BP1 Gene

Post-translational modifications for TOP3BP1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TOP3BP1 Gene

Domains & Families for TOP3BP1 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TOP3BP1 Gene

Function for TOP3BP1 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TOP3BP1 Gene

Localization for TOP3BP1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TOP3BP1 Gene

Pathways & Interactions for TOP3BP1 Gene

SuperPathways for TOP3BP1 Gene

No Data Available

Interacting Proteins for TOP3BP1 Gene

Gene Ontology (GO) - Biological Process for TOP3BP1 Gene


No data available for Pathways by source and SIGNOR curated interactions for TOP3BP1 Gene

Transcripts for TOP3BP1 Gene

mRNA/cDNA for TOP3BP1 Gene

(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TOP3BP1 Gene

No ASD Table

Relevant External Links for TOP3BP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TOP3BP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TOP3BP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TOP3BP1 Gene:

genes like me logo Genes that share expression patterns with TOP3BP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TOP3BP1 Gene

Orthologs for TOP3BP1 Gene

Evolution for TOP3BP1 Gene

Gene Tree for TOP3BP1 (if available)
Gene Tree for TOP3BP1 (if available)

No data available for Orthologs for TOP3BP1 Gene

Paralogs for TOP3BP1 Gene

No data available for Paralogs for TOP3BP1 Gene

Variants for TOP3BP1 Gene

Relevant External Links for TOP3BP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TOP3BP1 Gene

Disorders for TOP3BP1 Gene

Relevant External Links for TOP3BP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TOP3BP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TOP3BP1 Gene

Publications for TOP3BP1 Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 64
  2. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K. … Shimizu N. (Genome Res. 1997) 3 64

Products for TOP3BP1 Gene

Sources for TOP3BP1 Gene

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