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Aliases for TOP3BP1 Gene

Aliases for TOP3BP1 Gene

  • DNA Topoisomerase III Beta Pseudogene 1 2 3 5
  • Topoisomerase (DNA) III Beta, 2 2 3
  • Topoisomerase (DNA) III Beta Pseudogene 1 3
  • TOP3B2 3

External Ids for TOP3BP1 Gene

Previous HGNC Symbols for TOP3BP1 Gene

  • TOP3B2

Previous GeneCards Identifiers for TOP3BP1 Gene

  • GC22M022582

Summaries for TOP3BP1 Gene

Entrez Gene Summary for TOP3BP1 Gene

  • This gene was predicted by automated computational analysis. It encodes a protein with similarity to human topoisomerase (DNA) III beta, which is thought to relax supercoiled DNA upon replication, transcription, and cell division. This gene lies in the immunoglobulin lambda gene cluster on chromosome 22q11.21. [provided by RefSeq, Jul 2008]

GeneCards Summary for TOP3BP1 Gene

TOP3BP1 (DNA Topoisomerase III Beta Pseudogene 1) is a Pseudogene.

Additional gene information for TOP3BP1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOP3BP1 Gene

Genomics for TOP3BP1 Gene

GeneHancer (GH) Regulatory Elements for TOP3BP1 Gene

Promoters and enhancers for TOP3BP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I021936 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 56 +279.8 279819 17.5 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 PPM1F ENSG00000224086 TOP3BP1 TOP3B LZTR1 IGLV5-52 PPIL2 ENSG00000234630 ENSG00000272779 THAP7
GH22I021864 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.8 +357.4 357442 4.3 HDGF PKNOX1 CLOCK MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B MAPK1 ENSG00000224086 TOP3BP1 IGLV5-52 SDF2L1 HIC2 RNA5SP493
GH22I021834 Enhancer 1.2 Ensembl ENCODE dbSUPER 16.3 +387.9 387947 4.4 PKNOX1 ATF1 FOXA2 INSM2 ZNF366 RUNX3 EGR2 ZNF280D ZNF362 ZEB2 ENSG00000224086 TOP3BP1 PPM1F PI4KAP2 MAPK1 RNA5SP493
GH22I021981 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.3 +242.0 241965 1.6 PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 TOP3B IGLV5-52 ENSG00000234630 ENSG00000224086 PPIL2 ENSG00000272779 TUBA3FP ENSG00000225544 THAP7-AS1 ENSG00000273342
GH22I021772 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.5 +450.5 450520 3.6 HDGF HNRNPUL1 CTCF KLF1 TSC22D4 PYGO2 RAD21 RELA IRF9 ZNF121 TOP3B ENSG00000224086 IGLV5-52 LZTR1 PPIL2 ENSG00000234630 YPEL1 TOP3BP1 PPM1F ENSG00000225544
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TOP3BP1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TOP3BP1 Gene

Genomic Locations for TOP3BP1 Gene
chr22:22,223,186-22,224,566
(GRCh38/hg38)
Size:
1,381 bases
Orientation:
Minus strand
chr22:22,577,579-22,578,959
(GRCh37/hg19)

Genomic View for TOP3BP1 Gene

Genes around TOP3BP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOP3BP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOP3BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOP3BP1 Gene

Proteins for TOP3BP1 Gene

Post-translational modifications for TOP3BP1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TOP3BP1 Gene

Domains & Families for TOP3BP1 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TOP3BP1 Gene

Function for TOP3BP1 Gene

Phenotypes From GWAS Catalog for TOP3BP1 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TOP3BP1 Gene

Localization for TOP3BP1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TOP3BP1 Gene

Pathways & Interactions for TOP3BP1 Gene

SuperPathways for TOP3BP1 Gene

No Data Available

Interacting Proteins for TOP3BP1 Gene

Gene Ontology (GO) - Biological Process for TOP3BP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TOP3BP1 Gene

Drugs & Compounds for TOP3BP1 Gene

No Compound Related Data Available

Transcripts for TOP3BP1 Gene

mRNA/cDNA for TOP3BP1 Gene

(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOP3BP1 Gene

No ASD Table

Relevant External Links for TOP3BP1 Gene

GeneLoc Exon Structure for
TOP3BP1
ECgene alternative splicing isoforms for
TOP3BP1

Expression for TOP3BP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TOP3BP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TOP3BP1 Gene:

TOP3BP1
genes like me logo Genes that share expression patterns with TOP3BP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TOP3BP1 Gene

Orthologs for TOP3BP1 Gene

Evolution for TOP3BP1 Gene

ENSEMBL:
Gene Tree for TOP3BP1 (if available)
TreeFam:
Gene Tree for TOP3BP1 (if available)

No data available for Orthologs for TOP3BP1 Gene

Paralogs for TOP3BP1 Gene

No data available for Paralogs for TOP3BP1 Gene

Variants for TOP3BP1 Gene

Additional Variant Information for TOP3BP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TOP3BP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TOP3BP1 Gene

Disorders for TOP3BP1 Gene

Additional Disease Information for TOP3BP1

No disorders were found for TOP3BP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TOP3BP1 Gene

Publications for TOP3BP1 Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 2 3 58
  2. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K … Shimizu N (Genome research 1997) 3 58

Products for TOP3BP1 Gene

Sources for TOP3BP1 Gene

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