TOP3B Gene
protein-coding GIFtS: 56
GCID: GC22M022309
|
|
topoisomerase (DNA) III beta
| |
Aliases
for TOP3B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Topoisomerase (DNA) III Beta1 2 | | DNA Topoisomerase III Beta-12 3 | | DNA Topoisomerase 3-Beta-12 | | Topoisomerase III Beta2 | | EC 5.99.1.23 | | TOP3B13 |
Export aliases for TOP3B gene to outside databasesPrevious GC identifers: GC22M019010 GC22M020635 GC22M021075 GC22M005268 |
Summaries
for TOP3B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TOP3B:
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA duringtranscription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows thestrands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzymeinteracts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genomestability. Alternative splicing of the C-terminus of this gene results in three transcript variants which havedistinct tissue specificity; however, not all variants have been fully described. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TOP3B_HUMAN, O95985Function: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication andtranscription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break viatransesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosineof the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils.Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine andrestore the DNA phosphodiester backbone (By similarity). Possesses negatively supercoiled DNA relaxing activity
Gene Wiki entry for TOP3B
|
Genomic Views
for TOP3B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TOP3B gene promoter:
Max1 USF1 Olf-1 STAT5A Arnt Evi-1 POU2F1 USF-1 POU2F1a c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for TOP3B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOP3B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q11.22 Ensembl cytogenetic band: 22q11.22 HGNC cytogenetic band: 22q11.22TOP3B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M022309: view genomic region
(about GC identifiers)
Start:
|
22,311,397 bp from pter |
End:
|
22,337,213 bp from pter |
Size:
|
25,817 bases |
Orientation:
|
minus strand |
|
Proteins
for TOP3B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TOP3B_HUMAN, O95985 (See
protein sequence)Recommended Name: DNA topoisomerase 3-beta-1 Size: 862 amino acids; 96662 Da
Sequence caution: Sequence=BAA20009.1; Type=Erroneous gene model prediction;
Secondary accessions: A0M8Q3 Q9BUP5Alternative splicing: 3 isoforms: O95985-1 O95985-2 O95985-3 Explore the universe of human proteins at neXtProt for TOP3B: NX_O95985
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95985
TOP3B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003926.1
ENSEMBL proteins: ENSP00000349705 ENSP00000408282 ENSP00000397221 ENSP00000381773 ENSP00000392480 ENSP00000416451 ENSP00000390977 ENSP00000402622 ENSP00000414538 ENSP00000391857 ENSP00000404600 ENSP00000390209 ENSP00000387554 ENSP00000390824 ENSP00000393118
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TOP3B for ontologies About GeneDecksing
TOP3B Antibody Products:
Assay Products for TOP3B: |
Protein
Domains /
Families
for TOP3B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TOP3B for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry O95985ProtoNet protein and cluster: O95985 2 Blocks protein families: IPB000380 DNA topoisomerase I IPB006154 Toprim sub-domain
UniProtKB/Swiss-Prot: TOP3B_HUMAN, O95985Similarity: Belongs to the type IA topoisomerase familySimilarity: Contains 1 Toprim domain |
Function
for TOP3B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TOP3B_HUMAN, O95985Function: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication andtranscription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break viatransesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosineof the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils.Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine andrestore the DNA phosphodiester backbone (By similarity). Possesses negatively supercoiled DNA relaxing activityCatalytic activity: ATP-independent breakage of single-stranded DNA, followed by passage and rejoining Genatlas biochemistry entry for TOP3B:DNA topoisomerase III,highly expressed in testis,possessing negatively supercoiled DNA relaxing activity
Enzyme Number (IUBMB): EC 5.99.1.21
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOP3B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOP3B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TOP3B (NM_003935) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TOP3B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOP3B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOP3B |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
TOP3B for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TOP3B:
Animal Models:
Mouse knock-out Top3btm1Jcw for TOP3B
10 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Top3b):
TOP3B for phenotypes About GeneDecksing
|
Pathways & Interactions
for TOP3B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Homologous recombination | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for TOP3B):
TOP3B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TOP3B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/28 Interacting proteins for TOP3B (O959852, 3 ENSP000003497054) via UniProtKB, MINT, STRING, and/or I2D (see all 28)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006265 | DNA topological change |
IEA | -- | | GO:0007059 | chromosome segregation |
IEA | -- |
TOP3B for ontologies About GeneDecksing
|
Drugs & Compounds
for TOP3B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TOP3B
Search CenterWatch for drugs/clinical trials and news about TOP3B
|
Transcripts
for TOP3B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TOP3B gene: NM_003935.3 Unigene Cluster for TOP3B: Topoisomerase (DNA) III beta Hs.436401 [show with all ESTs]Unigene Representative Sequence: AL83350518 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000357179(uc002zvt.4 uc010gtl.3) ENST00000457270 ENST00000457179
ENST00000398793(uc002zvs.3) ENST00000444502 ENST00000436282(uc010gtm.2)
ENST00000470338 ENST00000424393 ENST00000487485 ENST00000437929 ENST00000430142
ENST00000489581 ENST00000456075 ENST00000449704 ENST00000442653 ENST00000437103
ENST00000434517 ENST00000413067
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOP3B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOP3B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TOP3B (NM_003935) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TOP3B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOP3B |
Additional cDNA sequence: AF017146.1 AF053082.1 AF070585.1 AF125216.1 AK096695.1 AK290997.1 AK304681.1 AK304709.1 AL833505.1 BC002432.2 CR456596.1 23 DOTS entries: DT.100797125 DT.309289 DT.443791 DT.100649625 DT.100862509 DT.102832370 DT.100036358 DT.97858845 DT.100772496 DT.100643978 DT.100797127 DT.100832753 DT.102832372 DT.120647601 DT.92021190 DT.100665612 DT.100728463 DT.100797129 DT.100835026 DT.102832373 DT.120647612 DT.95157280 DT.95204324 24/139 AceView cDNA sequences (see all 139): BM719837 H55387 AI432376 AI904168 AF053082 AL833505 BM929485 CA453925 NM_003935 AF070585 AI368666 CR597544 CR625879 BQ649447 AF125216 CR456596 AK096695 BQ018902 BQ270362 BU739692 AF017146 CD107506 BU956077 BQ437166
GeneLoc Exon Structure
5/21 Alternative Splicing Database (ASD) splice patterns (SP) for TOP3B (see all 21) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | |
| ExUns: | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | · | 21c | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26 |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TOP3B
|
Expression
for TOP3B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TOP3B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCACTTCAAA
About this image
See TOP3B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TOP3B
SOURCE GeneReport for Unigene cluster: Hs.436401
UniProtKB/Swiss-Prot: TOP3B_HUMAN, O95985Tissue specificity: Isoform 1 is found in testis, heart and skeletal muscle. A 4 kb transcript which probablyrepresents isoform 2 is found in thymus, kidney and pancreas
SABiosciences Expression via Pathway-Focused PCR Array including TOP3B:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOP3B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TOP3B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOP3B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOP3B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOP3B |
Orthologs
for TOP3B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for TOP3B gene from 10/25 species (see all 25) About this table
ENSEMBL Gene Tree for TOP3B (if available)
TreeFam Gene Tree for TOP3B (if available) |
Paralogs
for TOP3B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TOP3B gene
- TOP3A2
1 SIMAP similar gene for TOP3B using alignment to 13 protein entries: TOP3B_HUMAN (see all proteins):TOP3A
TOP3B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TOP3B
PGOHUM00000246269
|
Genomic Variants
for TOP3B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TOP3B (22311397 - 22337213 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for TOP3B
13 CNVs: 53209 2264 50818 34540 50819 73774 5355 5356 50820 5354 53864 4118 31073 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOP3B |
|
Disorders
/ Diseases
for TOP3B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TOP3B for disorders About GeneDecksing
OMIM gene information: 603582
OMIM disorders: --
8  diseases for TOP3B: About MalaCardsdna topoisomerase i tetralogy of fallot vaccinia lung carcinoma
pneumonia carcinoma tuberculosis mycobacterium tuberculosis
Export disorders for TOP3B gene to outside databases
|
Publications
for TOP3B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TOP3B gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with TOP3B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PubMed id 9074928)1, 2, 3 Kawasaki K....Shimizu N. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- A new human topoisomerase III that interacts with SGS1 protein. (PubMed id 9927731)1, 2 Ng S.-W.... Berkowitz R.S. (1999)
- Cleavage of DFF-45/ICAD by multiple caspases is essential for its function during apoptosis. (PubMed id 9786842)1, 3 Tang D. and Kidd V.J. (1998)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Significance of topoisomerase IIII^ expression in brea st ductal carcinomas: strong associations with disease-specific survival and me tastasis. (PubMed id 20950730)1 Oliveira-Costa J.P....Ribeiro-Silva A. (2010)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
|
External Searches for TOP3B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TOP3B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TOP3B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TOP3B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TOP3B gene:
Search GeneIP for patents involving TOP3B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TOP3B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TOP3B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TOP3B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOP3B | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TOP3B | | OriGene 3'-UTR Clone for TOP3B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOP3B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOP3B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TOP3B | | OriGene Custom Protein Services for TOP3B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TOP3B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOP3B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOP3B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOP3B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOP3B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOP3B |
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| | | | Search Tocris compounds for TOP3B |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOP3B |
|  |  |  | | | | Search ThermoFisher Antibodies for TOP3B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOP3B |
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