TOP3A Gene
protein-coding GIFtS: 60
GCID: GC17M018175
|
|
topoisomerase (DNA) III alpha
(Previous symbol: TOP3)
| |
Aliases
for TOP3A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Topoisomerase (DNA) III Alpha1 2 | | TOP31 2 3 | | DNA Topoisomerase III Alpha2 3 | | DNA Topoisomerase 3-Alpha2 | | Topo III-Alpha2 | | EC 5.99.1.23 |
Export aliases for TOP3A gene to outside databasesPrevious GC identifers: GC17M018422 GC17M019769 GC17M018117 GC17M018377 GC17M017930 |
Summaries
for TOP3A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TOP3A:
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA duringtranscription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows thestrands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. Thisenzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TOP3A_HUMAN, Q13472Function: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication andtranscription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break viatransesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosineof the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils.Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine andrestore the DNA phosphodiester backbone. Essential component of the RMI complex, a complex that plays an importantrole in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNAdecatenation activity
Gene Wiki entry for TOP3A
|
Genomic Views
for TOP3A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TOP3A gene promoter:
AREB6 Elk-1 STAT1 Pax-2b Pax-2 STAT1beta Pax-2a STAT1alpha YY1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TOP3A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOP3A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p12-p11.2 Ensembl cytogenetic band: 17p11.2 HGNC cytogenetic band: 17p12-p11.2TOP3A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M018175: view genomic region
(about GC identifiers)
Start:
|
18,174,742 bp from pter |
End:
|
18,218,321 bp from pter |
Size:
|
43,580 bases |
Orientation:
|
minus strand |
|
Proteins
for TOP3A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TOP3A_HUMAN, Q13472 (See
protein sequence)Recommended Name: DNA topoisomerase 3-alpha Size: 1001 amino acids; 112372 Da
Cofactor: Magnesium
Subunit: Directly interacts with BLM and RMI1. Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2.The RMI complex interacts with BLM
Secondary accessions: A8KA61 D3DXC7 Q13473Alternative splicing: 2 isoforms: Q13472-1 Q13472-2 Explore the universe of human proteins at neXtProt for TOP3A: NX_Q13472
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13472
TOP3A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004609.1
ENSEMBL proteins: ENSP00000465014 ENSP00000390518 ENSP00000465864 ENSP00000321636 ENSP00000462136 ENSP00000462378 ENSP00000462790 ENSP00000466099 ENSP00000466641 ENSP00000464338 ENSP00000464493 ENSP00000442336 ENSP00000446425 Reactome Protein details: Q13472
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TOP3A for ontologies About GeneDecksing
TOP3A Antibody Products:
Assay Products for TOP3A: |
Protein
Domains /
Families
for TOP3A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TOP3A for domains About GeneDecksing
5/12 InterPro domains/families (see all 12):Graphical View of Domain Structure for InterPro Entry Q13472ProtoNet protein and cluster: Q13472 4 Blocks protein families: IPB000380 DNA topoisomerase I IPB001878 C2HC-type zinc-finger signature IPB006154 Toprim sub-domain IPB010666 GRF zinc finger
UniProtKB/Swiss-Prot: TOP3A_HUMAN, Q13472Similarity: Belongs to the type IA topoisomerase familySimilarity: Contains 1 Toprim domain |
Function
for TOP3A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TOP3A_HUMAN, Q13472Function: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication andtranscription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break viatransesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosineof the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils.Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine andrestore the DNA phosphodiester backbone. Essential component of the RMI complex, a complex that plays an importantrole in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNAdecatenation activityCatalytic activity: ATP-independent breakage of single-stranded DNA, followed by passage and rejoining Genatlas biochemistry entry for TOP3A:DNA topoisomerase III,putatively involved in suppression of mitotic recombination between repetitive sequences,deletedin SMCR
Enzyme Number (IUBMB): EC 5.99.1.21
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOP3A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOP3A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TOP3A (NM_004618) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TOP3A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOP3A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOP3A |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
TOP3A for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TOP3A:
Animal Models:
Mouse knock-out Top3atm1Jcw for TOP3A
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Top3a):
TOP3A for phenotypes About GeneDecksing
|
Pathways & Interactions
for TOP3A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Formation of Meiotic Holliday Junction | | | 2 | Meiotic Synapsis | | | 3 | Meiosis | | | 4 | Homologous recombination | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for TOP3A
4 
Reactome Pathways for TOP3A
1 
Kegg Pathway (Kegg details for TOP3A):
TOP3A for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TOP3A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/116 Interacting proteins for TOP3A (Q134722, 3 ENSP000003216364) via UniProtKB, MINT, STRING, and/or I2D (see all 116)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| BLM | P541322, 3, ENSP000003472324 | MINT-8048980 MINT-8049128 MINT-8048995 MINT-8049010 MINT-8415512 MINT-8048961 MINT-8049038 I2D:
score=5 STRING: ENSP00000347232 | | PML | P295902, 3, ENSP000002680584 | MINT-6743913 MINT-6743884 MINT-6743926 MINT-6744122 I2D:
score=1 STRING: ENSP00000268058 | | FANCA | O153602, 3, ENSP000003739524 | MINT-8141040 I2D:
score=2 STRING: ENSP00000373952 | | TINF2 | Q9BSI42, 3, ENSP000002674154 | MINT-6744065 I2D:
score=1 STRING: ENSP00000267415 | | RMI1 | Q9H9A72, 3, ENSP000003170394 | MINT-8048980 MINT-8049128 MINT-8048995 MINT-8049010 MINT-8048961 MINT-8049038 I2D:
score=2 STRING: ENSP00000317039 |
About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
TOP3A for ontologies About GeneDecksing
|
Drugs & Compounds
for TOP3A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TOP3A for compounds About GeneDecksing
 Browse Tocris compounds for TOP3A
2 Novoseek chemical compound relationships for TOP3A gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| methylmethanesulfonate |
69.1 |
2 |
15590327 (1) |
| hydroxyurea |
56.9 |
2 |
11585898 (1) |
Search CenterWatch for drugs/clinical trials and news about TOP3A
|
Transcripts
for TOP3A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TOP3A gene: NM_004618.3 Unigene Cluster for TOP3A: Topoisomerase (DNA) III alpha Hs.592115 [show with all ESTs]Unigene Representative Sequence: NM_00461818/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22): ENST00000493648 ENST00000412083 ENST00000489131 ENST00000469739(uc002gsw.1)
ENST00000321105(uc010cpz.1 uc010vxr.1 uc002gsx.1 uc010vxs.1)
ENST00000584582 ENST00000582981(uc010cqa.1) ENST00000580095 ENST00000477508
ENST00000582122 ENST00000581536 ENST00000583804 ENST00000461127 ENST00000584669
ENST00000583328 ENST00000472959 ENST00000585031 ENST00000582230
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOP3A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOP3A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TOP3A (NM_004618) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TOP3A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOP3A |
Additional cDNA sequence: AF086042.1 AK126869.1 AK290513.1 AK292926.1 AK296437.1 AK299764.1 AK311668.1 BC051748.1 U43431.1 10 DOTS entries: DT.309126 DT.95373118 DT.95132204 DT.97827020 DT.120950465 DT.100754182 DT.120950491 DT.100023593 DT.100754179 DT.91856693 24/135 AceView cDNA sequences (see all 135): AU130137 BU902730 AW450373 BU542042 BM793025 AI131044 BP350268 AI917456 BC051748 AW513442 AW139468 AI968390 AA307047 AI206134 BE378266 AW449041 BX348607 BP381656 BM046548 BM929666 CR593799 BM817686 BQ673046 AI676092
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TOP3A (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | - | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | - | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · | 20b |
|---|
|
| SP1: | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TOP3A
|
Expression
for TOP3A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TOP3A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGCAGTCCC
About this image
See TOP3A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TOP3A
SOURCE GeneReport for Unigene cluster: Hs.592115
UniProtKB/Swiss-Prot: TOP3A_HUMAN, Q13472Tissue specificity: High expression is found in testis, heart, skeletal muscle and pancreas
SABiosciences Expression via Pathway-Focused PCR Array including TOP3A:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOP3A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TOP3A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOP3A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOP3A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOP3A |
Orthologs
for TOP3A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for TOP3A gene from 10/35 species (see all 35) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TOP3A1 |
topoisomerase (DNA) III alpha |
70.86(n)
74.52(a) |
|
416517 NM_001030636.2 NP_001025807.1 |
lizard
(Anolis carolinensis) |
Reptilia |
TOP3A6 |
-- |
73(a) |
1 ↔ 1 |
GL343618.1(177099-191373) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.89422 |
Xenopus laevis transcribed sequence with weak similarity more |
81.66(n) |
|
BQ386610.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
top3a1 |
topoisomerase (DNA) III alpha |
64.89(n)
68.45(a) |
|
560212 XM_683603.5 XP_688695.4 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Top3alpha1 , 3 |
DNA topoisomerase I3
Topoisomerase 3alpha1 |
58(a)3
55.88(n)1
55.36(a)1 |
|
37E43
352361 NM_078878.21 NP_523602.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
top-31 , 3 |
DNA topoisomerase III3
Protein TOP-31 |
51(a)3
53.72(n)1
52.63(a)1 |
|
III(12021663-12031813)3
1766311 NM_067157.31 NP_499558.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
TOP31 |
Top3p |
50.6(n)
45.44(a) |
|
850935 NP_013335.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
TOP3A1 |
DNA topoisomerase III |
52.01(n)
46.9(a) |
|
836513 NM_125788.6 NP_201197.1 |
rice
(Oryza sativa) |
Liliopsida |
Os03g01650001 |
hypothetical protein |
51.85(n)
45.8(a) |
|
9269718 NM_001186349.1 NP_001173278.1 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
topB6 |
DNA topoisomerase III |
18(a) |
possible ortholog |
Chromosome(1843023-1844984) |
ENSEMBL Gene Tree for TOP3A (if available)
TreeFam Gene Tree for TOP3A (if available) |
Paralogs
for TOP3A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TOP3A gene
- TOP3B2
1 SIMAP similar gene for TOP3A using alignment to 12 protein entries: TOP3A_HUMAN (see all proteins):TOP3B
TOP3A for paralogs About GeneDecksing
|
Genomic Variants
for TOP3A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TOP3A (18174742 - 18218321 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TOP3A
1 Inversion: 0495 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOP3A |
|
Disorders
/ Diseases
for TOP3A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TOP3A for disorders About GeneDecksing
OMIM gene information: 601243
OMIM disorders: --
20  diseases for TOP3A: About MalaCardsfanconi anemia, complementation group m rothmund-thomson syndrome smith-magenis syndrome dna topoisomerase i
fanconi's anemia ataxia telangiectasia bloom syndrome werner syndrome
appendicitis anemia albinism vaccinia
ataxia breast cancer pneumonia hypoxia
tuberculosis malaria leukemia mycobacterium tuberculosis
3 diseases from the University of Copenhagen DISEASES database for TOP3A:Bloom syndrome Werner syndrome Rothmund-Thomson syndrome 1 Novoseek disease relationship for TOP3A gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0 |
13 |
17563752 (2), 17483326 (1), 16324386 (1) |
Human Genome Epidemiology (HuGE) Navigator: TOP3A (1 document)
Export disorders for TOP3A gene to outside databases
|
Publications
for TOP3A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TOP3A gene, integrated from 9 sources (see all 72):
(articles sorted by number of sources associating them with TOP3A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human TOP3: a single-copy gene encoding DNA topoisomerase III. (PubMed id 8622991)1, 2, 9 Hanai R.... Wang J.C. (1996)
- Human topoisomerase IIIalpha is a single-stranded DNA decatenase that is stimulated by BLM and RMI1. (PubMed id 20445207)1, 2 Yang J....Brown G.W. (2010)
- Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing. (PubMed id 20843780)1, 2 Wang W....Scharfe C. (2010)
- BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity. (PubMed id 15775963)1, 2 Yin J.... Wang W. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A ubiquitin-binding protein, FAAP20, links RNF8-mediat ed ubiquitination to the Fanconi anemia DNA repair network. (PubMed id 22705371)1 Yan Z....Wang W. (2012)
- A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome. (PubMed id 21240188)1 Suhasini A.N....Brosh R.M. (2011)
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External Searches for TOP3A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing TOP3A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing TOP3A gene
(According to HUGE)
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Specialized Databases showing TOP3A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for TOP3A | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for TOP3A gene:
Search GeneIP for patents involving TOP3A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TOP3A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TOP3A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TOP3A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOP3A | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TOP3A | | OriGene 3'-UTR Clone for TOP3A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOP3A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOP3A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TOP3A | | OriGene Custom Protein Services for TOP3A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TOP3A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOP3A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOP3A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOP3A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOP3A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOP3A |
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| | | | Search Tocris compounds for TOP3A |
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 | | | TOP3A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOP3A |
|  |  |  | | | | Search ThermoFisher Antibodies for TOP3A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOP3A |
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