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TOP2B Gene

protein-coding GIFtS: 66

GC03M025614

topoisomerase (DNA) II beta 180kDa
(Previous name: topoisomerase (DNA) II beta (180kD) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 5.99.1.3 ^³
TOPIIB ^²
top2beta ^²

Descriptions
DNA topoisomerase II beta ^²
DNA topoisomerase II, 180 kD ^²
DNA topoisomerase II, beta isozyme ^², ³
U937 associated antigen ^²
antigen MLAA-44 ^²
topo II beta ^²
topoisomerase (DNA) II beta (180kD) ^¹, ²
topoisomerase (DNA) II beta 180kDa ^²
topoisomerase II beta ^²
topoisomerase II beta 180kDa ^¹
topoisomerase IIb ^²

External Ids
HGNC: 11990¹
Entrez Gene: 7155²
UniProtKB: Q02880³
Ensembl: ENSG00000077097⁷

Search outside databases for aliases for TOP2B gene

Previous GC identifers: GC03M025346 GC03M025489

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TOP2B:

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of

DNA during transcription. This nuclear enzyme is involved in processes such as chromosome

condensation, chromatid separation, and the relief of torsional stress that occurs during DNA

transcription and replication. It catalyzes the transient breaking and rejoining of two strands of

duplex DNA which allows the strands to pass through one another, thus altering the topology of

DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene

encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to

chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents

and a variety of mutations in this gene have been associated with the development of drug

resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.

Alternative splicing of this gene results in two transcript variants; however, the second variant

has not yet been fully described. [provided by RefSeq]

UniProtKB/Swiss-Prot: TOP2B_HUMAN, Q02880

Function: Control of topological states of DNA by transient breakage and subsequent rejoining of

DNA strands. Topoisomerase II makes double-strand breaks. Indirectly ivolved in vitamin D-coupled

transcription regulation via its association with the WINAC complex, a chromatin-remodeling

complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated

transrepression of the CYP27B1 gene

Gene Wiki entry for TOP2B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24 Ensembl cytogenetic band: 3p24.2 HGNC cytogenetic band: 3p24

TOP2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M025614: (about GC identifiers)

Start:	25,614,479 bp from pter
End:	25,680,792 bp from pter
Size:	66,314 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000003.10 NT_022517.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TOP2B_HUMAN, Q02880 (See protein sequence)

Recommended Name: DNA topoisomerase 2-beta

Size: 1626 amino acids; 183267 Da

Subunit: Homodimer. Component of the WINAC complex, at least composed of SMARCA2, SMARCA4, SMARCB1,

SMARCC1, SMARCC2, SMARCD1, SMARCE1, ACTL6A, BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A and TOP2B

Subcellular location: Cytoplasm. Nucleus, nucleolus

Miscellaneous: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils,

whereas prokaryotic enzymes relax only negative supercoils

Secondary accessions: Q13600 Q9UMG8 Q9UQP8

Alternative splicing: 2 isoforms: Q02880-1 Q02880-2

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001059.2

ENSEMBL proteins:

ENSP00000264331

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Topoisomerase II beta)
	Human Recombinant Proteins from Abnova (TOP2B)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000792	colocalizes with heterochromatin	IDA	9049244
GO:0005634	nucleus	IDA	9049244
GO:0005654	nucleoplasm	IDA	9049244
GO:0005694	chromosome	IEA	--
GO:0005730	NOT nucleolus	IDA	9049244

About this table

Antibodies for TOP2B:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for TOP2B
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for TOP2B (Topo II beta)
	Antibodies from Abcam (Topoisomerase II beta), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TOP2B)
	Novus Biologicals Antibodies for TOP2B

Assays for TOP2B:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q02880

ProtoNet protein and cluster: Q02880

5/6 Blocks protein families (see all 6 ):

IPB001154 Topoisomerase II signature

IPB002205 DNA gyrase/topoisomerase IV

IPB003594 ATP-binding region

IPB003957 CCAAT-binding transcription factor subunit A signature

IPB011558 DNA topoisomerase

UniProtKB/Swiss-Prot: TOP2B_HUMAN, Q02880

Similarity: Belongs to the type II topoisomerase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TOP2B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TOP2B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001068

Applied Biosystems Silencer® siRNAs for TOP2B

Sigma-Aldrich siRNA and siRNA Panels for TOP2B

Sigma-Aldrich shRNA for TOP2B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001068
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001068
untagged cDNA clone in CMV expression vector: NM_001068

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001068

UniProtKB/Swiss-Prot: TOP2B_HUMAN, Q02880

Function: Control of topological states of DNA by transient breakage and subsequent rejoining of

DNA strands. Topoisomerase II makes double-strand breaks. Indirectly ivolved in vitamin D-coupled

transcription regulation via its association with the WINAC complex, a chromatin-remodeling

complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated

transrepression of the CYP27B1 gene

Catalytic activity: ATP-dependent breakage, passage and rejoining of double-stranded DNA

Enzyme Number (IUBMB): EC 5.99.1.3

Genatlas biochemistry entry for TOP2B:

DNA topoisomerase II beta (180kDa),ubiquitous,ATPase component of the topoisomerase II,involved in

the breakage and rejoining of double strand of DNA,relaxing both positively and negatively

supercoiled DNA,target of several drugs,widely used in the treatment of human cancers

8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Top2b):

behavior/neurological	embryogenesis	growth/size	lethality-prenatal/perinatal	nervous system
normal	respiratory system	skeleton

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003682	chromatin binding	IDA	9049244
GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity	IEA	--
GO:0005080	protein kinase C binding	IPI	16611985
GO:0005524	ATP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for TOP2B (Your Favorite Gene powered by Ingenuity)

Cell Cycle: G2/M DNA Damage Checkpoint Regulation

GeneDecks TOP2B for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for TOP2B

5/29 Interacting proteins for TOP2B (ENSP00000264331³) via UniProtKB, MINT, and/or STRING (see all 29 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TOPBP1	ENSP00000260810³	STRING (score=.989)
GSTP1	ENSP00000196968³	STRING (score=.957)
TOP1	ENSP00000354522³	STRING (score=.915)
TP53	ENSP00000269305³	STRING (score=.915)
HDAC7	ENSP00000309766³	STRING (score=.882)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001764	neuron migration	IEA	--
GO:0006265	DNA topological change	IEA	--
GO:0007409	axonogenesis	IEA	--
GO:0030900	forebrain development	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for TOP2B

Sigma-Aldrich Small Molecules for TOP2B:

Inhibitor

Compounds for TOP2B available from Tocris Bioscience

Compound	Action	CAS number
Epirubicin hydrochloride	Inhibits DNA synthesis and function. Inhibits DNA topoisomerase II.	[56390-09-1]
Doxorubicin hydrochloride	Antitumor antibiotic agent. Inhibits DNA topoisomerase II	[25316-40-9]
Etoposide	Topoisomerase II inhibitor	[33419-42-0]

About this table

2 Novoseek chemical compound relationships for TOP2B gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gal 1	53.59	1	9025779 (1)
atp	10.80	2	12505993 (2)

About this table

1 PharmGKB drug compound relationship for TOP2B gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
etoposide	CO FA	2934259 9748598 3030329 7979257

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TOP2B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TOP2B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001068

Sigma-Aldrich siRNA and siRNA Panels for TOP2B

Sigma-Aldrich shRNA for TOP2B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001068

REFSEQ mRNAs for TOP2B gene:

NM_001068.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001068

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001068
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001068
                                 untagged cDNA clone in CMV expression vector: NM_001068

Additional cDNA sequence:

AB208879.1 AK296510.1 AK297171.1 AK307450.1 AK316492.1 BC021863.1 BC054482.1 CR600074.1

CR602047.1 CR606570.1 CR621848.1 M27504.1 U54831.1 X53662.1 X68060.1 Z15111.1

Z15115.1

24/26 DOTS entries (see all 26 ):

DT.95356606 DT.218512 DT.95356610 DT.95356602 DT.100036996 DT.102833608 DT.97767947 DT.95356591

DT.100818472 DT.97854739 DT.120925291 DT.95356601 DT.100818466 DT.414721 DT.92452497 DT.120925234

DT.92326151 DT.100748508 DT.40115718 DT.92452485 DT.95082622 DT.99963850 DT.120925304 DT.92450337

24/466 AceView cDNA sequences (see all 466 ):

BM977738 AA322534 BQ430963 AU124793 AW058486 T59934 BM835620 BQ440714

BQ216298 AI478835 BU680806 AA424448 AI874120 N93010 N63584 AA318144

BE503615 M27504 BC021863 BQ223532 AU130052 BQ433345 AV715768 BQ421366

highest scoring ESTs for TOP2B:

X68060 M27504 Z15111 AA031925 AA031996 AA055323 AA092004 AA115016 AA115017 AA199624

Unigene Cluster for TOP2B:

Topoisomerase (DNA) II beta 180kDa

Hs.475733 [show with all ESTs]

Unigene Representative Sequence: NM_001068

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000264331

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TOP2B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TOP2B

¹ / ² / ³

4 probe-sets matching TOP2B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36571_at²^{, 3}	U95-A	1	1.00	1.00	0.89	1.32	X68060	1.00	1.00	1.00	1
1581_s_at²^{, 3}	U95-A	1	1.00	1.00	0.97	0.68	M27504	0.80	1.00	0.91	1
211987_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001068	0.60	1.00	0.82	1
211987_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTTACAAACT

SOURCE GeneReport for Unigene cluster: Hs.475733
Expression variation in blood from EXPOLDB for TOP2B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TOP2B gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TOP2B¹	--	topoisomerase (DNA) II beta 180kDa	95.32(n) 98.37(a)	477044 XM_534241.2 XP_534241.2
chimpanzee (Pan troglodytes)	TOP2B¹	--	topoisomerase (DNA) II beta 180kDa	99.77(n) 99.87(a)	460232 XM_516332.2 XP_516332.2
cow (Bos taurus)	TOP2B¹	--	topoisomerase (DNA) II beta 180kDa	92.35(n) 97.32(a)	787256 XM_001254709.1 XP_001254710.1
mouse (Mus musculus)	Top2b^{1, 5}	14⁵	topoisomerase (DNA) II beta^{1, 5}	91.95(n)¹ 96.4(a)¹	21974¹ NM_009409.2¹ NP_033435.2¹ AI465513⁵ AK041054⁵ (see all 14)
chicken (Gallus gallus)	TOP2B¹	--	topoisomerase (DNA) II beta 180kDa	83.54(n) 89.53(a)	395966 NM_205082.1 NP_990413.1

About this table Species with no ortholog for TOP2B

ENSEMBL Gene Tree for TOP2B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TOP2B gene

TOP2A²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/262 NCBI SNPs in TOP2B are shown (see all 262 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 88)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1369601^1,2	A,C,F,H	25682453(+)	`AAACAA/GGGCCC`	1	--	ng3¹		8	NA EA MN EU WA	848
	rs17016875^1,2	C,F,H	25625816(+)	`TGATGT/CAGGTG`	1	A/T	mis¹ ese³		7	NA EU EA WA	548
	rs17016865^1,2	C,F,H	25615938(+)	`GCTTGT/CTGTTT`	1	A/T	mis¹ ese³		11	NA EU EA WA	970
	rs1369600^1,2	A,F	25682444(+)	`TCAAAG/ATAAAA`	1	--	ng3¹		3	NA EA	251
--	rs4681031^1,2	H	25654753(+)	`GTGTTC/TTACTA`	1	E/K	mis¹ ese³		4	EU EA WA	406
	rs9880037^1,2	H	25682305(+)	`TGAAAA/GTTACC`	1	--	ng3¹ tfbs³		4	EU EA WA	418
	rs3806630^1,2	F	25682195(-)	`AGGGGG/ACACAG`	1	--	ng3¹ tfbs³		1	EA	1316
	rs6534^1,2	C,F,O	25629052(-)	`ACAGCT/CATGAA`	1	A/A	syn¹		5	MN NA	364
	rs1881708^1,2	A,C,F,H,O	25620518(+)	`AACCAG/ATTTCT`	1	--	int¹		8	NA EA MN EU WA	854
	rs1344827^1,2	A,C,F,H,O	25650641(+)	`CTTAGT/CGGCAT`	1	--	int¹		8	MN EU EA WA NA	744

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HapMap Linkage Disequilibrium images for TOP2B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 126431

6 Novoseek disease relationships for TOP2B gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
colon carcinoma	39.62	1	7980648 (1)
leukemia	29.97	2	7980648 (1), 1655025 (1)
poisoning	1.46	1	12769776 (1)
cancer lung	0.00	1	8398710 (1)
cancer	0.00	1	7797575 (1)
tumors	0.00	5	8547322 (4), 8759604 (1)

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2 PharmGKB disease relationships for TOP2B gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	CO FA GN	12086872 9748598
Leukemia, Myelocytic, Acute	CO	9748598

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/125 PubMed articles for TOP2B gene (see all 125 ):

Isolation of cDNA clones encoding the beta isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24. (PubMed id 1333583)^{1, 2, 3, 4} Jenkins J.R....Hickson I.D. (1992)
Molecular cloning and characterization of the human topoisomerase IIalpha and IIbeta genes: evidence for isoform evolution through gene duplication. (PubMed id 10095062)^{1, 3, 4} Sng J.H.... Fisher L.M. (1999)
Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)^{3, 4} Nousiainen M.... Koerner R. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
Identification of functional nuclear export sequences in human topoisomerase IIalpha and beta. (PubMed id 12821127)^{3, 4} Mirski S.E.... Cole S.P. (2003)
The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome. (PubMed id 12837248)^{3, 4} Kitagawa H....Kato S. (2003)
Human cells express two differentially spliced forms of topoisomerase II beta mRNA. (PubMed id 8396237)^{3, 4} Davies S.L.... Hickson I.D. (1993)
Novel HeLa topoisomerase II is the II beta isoform: complete coding sequence and homology with other type II topoisomerases. (PubMed id 8383537)^{3, 4} Austin C.A.... Fisher L.M. (1993)
Topoisomerase II alpha and topoisomerase II beta genes: characterization and mapping to human chromosomes 17 and 3, respectively. (PubMed id 1309226)^{2, 3} Tan K.B....Mao J. (1992)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7155	HGNC: 11990	AceView: TOP2B	Ensembl:ENSG00000077097	euGenes: HUgn7155
ECgene: TOP2B	H-InvDB: TOP2B

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for TOP2B	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for TOP2B
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TOP2B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TOP2B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TOP2B		Antibodies for TOP2B
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TOP2B		Small molecules for TOP2B
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TOP2B)
	Antibodies (TOP2B)
	Chimera RNAi (TOP2B)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for TOP2B (Topo II beta)

	Recombinant Proteins (Topoisomerase II beta)
	Antibodies (Topoisomerase II beta)

Search OriGene for TOP2B

Tocris compounds for TOP2B

	Drugs for TOP2B
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TOP2B

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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TOP2B Gene at Home site.
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TOP2B Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for TOP2B

Summaries
for TOP2B

Genomic Location
for TOP2B

Proteins
for TOP2B

Protein Domains/
Families
for TOP2B

Gene Function
for TOP2B

Pathways & Interactions
for TOP2B

Drugs & Compounds
for TOP2B

Transcripts
for TOP2B

Expression
for TOP2B

Orthologs
for TOP2B

Paralogs
for TOP2B

SNPs/Variants
for TOP2B

Disorders & Mutations
for TOP2B

Medical News
for TOP2B

Publications
for TOP2B

Search for TOP2B

Genome Databases showing TOP2B

Other Databases showing TOP2B

Specialized Databases showing TOP2B

Licensable Technologies
for TOP2B

Services
for TOP2B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TOP2B Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor TOP2B

Summariesfor TOP2B

Genomic Locationfor TOP2B

Proteinsfor TOP2B

Protein Domains/Familiesfor TOP2B

Gene Functionfor TOP2B

Pathways & Interactionsfor TOP2B

Drugs & Compoundsfor TOP2B

Transcriptsfor TOP2B

Expression for TOP2B

Orthologsfor TOP2B

Paralogsfor TOP2B

SNPs/Variantsfor TOP2B

Disorders & Mutationsfor TOP2B

Medical Newsfor TOP2B

Publicationsfor TOP2B

Search for TOP2B

Genome Databases showing TOP2B

Other Databases showing TOP2B

Specialized Databases showing TOP2B

Licensable Technologiesfor TOP2B

Servicesfor TOP2B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TOP2B

Summaries
for TOP2B

Genomic Location
for TOP2B

Proteins
for TOP2B

Protein Domains/
Families
for TOP2B

Gene Function
for TOP2B

Pathways & Interactions
for TOP2B

Drugs & Compounds
for TOP2B

Transcripts
for TOP2B

Expression
for TOP2B

Orthologs
for TOP2B

Paralogs
for TOP2B

SNPs/Variants
for TOP2B

Disorders & Mutations
for TOP2B

Medical News
for TOP2B

Publications
for TOP2B

Licensable Technologies
for TOP2B

Services
for TOP2B