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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TOP2A Gene

protein-coding   GIFtS: 71
GCID: GC17M038544

Topoisomerase (DNA) II Alpha 170kDa

(Previous name: topoisomerase (DNA) II alpha (170kD))
(Previous symbol: TOP2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Topoisomerase (DNA) II Alpha 170kDa1 2     TP2A2
TOP21 2 3 5     DNA Gyrase2
DNA Topoisomerase II, Alpha Isozyme2 3     DNA Topoisomerase (ATP-Hydrolyzing)2
EC 5.99.1.33 8     DNA Topoisomerase 2-Alpha2
Topoisomerase (DNA) II Alpha (170kD)1     DNA Topoisomerase II, 170 KD2

External Ids:    HGNC: 119891   Entrez Gene: 71532   Ensembl: ENSG000001317477   OMIM: 1264305   UniProtKB: P113883   

Export aliases for TOP2A gene to outside databases

Previous GC identifers: GC17M038044 GC17M040720 GC17M038453 GC17M038919 GC17M038920 GC17M035798 GC17M034337


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TOP2A Gene:
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during
transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid
separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes
the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one
another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene
duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is
localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents
and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced
activity of this enzyme may also play a role in ataxia-telangiectasia. (provided by RefSeq, Jul 2010)

GeneCards Summary for TOP2A Gene: 
TOP2A (topoisomerase (DNA) II alpha 170kDa) is a protein-coding gene. Diseases associated with TOP2A include adenocarcinoma in situ, and inverted papilloma, and among its related super-pathways are Cell cycle Transition and termination of DNA replication and Cell Cycle, Mitotic. GO annotations related to this gene include chromatin binding and protein homodimerization activity. An important paralog of this gene is TOP2B.

UniProtKB/Swiss-Prot: TOP2A_HUMAN, P11388
Function: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands.
Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of
daughter chromosomes

summary for TOP2A Gene:
Topoisomerases are ubiquitously expressed enzymes that overcome topological problems in genomic DNA, which
can result from DNA replication, transcription and repair. Common problems such as overwinding (positive
supercoiling), knots and tangles are resolved by topoisomerases by catalysing the breaking of one or two
strands of DNA. Topoisomerase type I enzymes cut just one strand of the DNA double helix, and hence relax
supercoiling of the DNA. Four genes encode Type I topoisomerases, which include nuclear topoisomerase I
(TOP1) and mitochondrial topoisomerase I (TOP1MT). Type I enzymes can also be sub-divided into Types A and B
based on their different catalytic mechanism for generating single DNA strand breaks. TOP1 and TOP1MT are
both type 1B since they form 3'-phosphotyrosyl bonds. Camptothecin is a natural product inhibitor of TOP1
that has led to the discovery of derivatives that are clinically used anti-cancer drugs. Such inhibitors
trap the enzyme in a cleavage complex with DNA. Type II topoisomerases (IIA and IIB) are particular
important for the disentanglement of DNA, which is overcome by generating double stranded DNA breaks.
Dysregulation of type II enzymes can therefore have a potentially significant genotoxic effect. There is a
broad range of topoisomerase II inhibitors that are used clinically as anticancer agents.

Gene Wiki entry for TOP2A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TOP2A gene promoter:
         GR   ATF-2   RelA   NF-kappaB   E47   CRE-BP1   Msx-1   Zic3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTOP2A promoter sequence
   Search SABiosciences Chromatin IP Primers for TOP2A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOP2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21-q22   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21-q22

TOP2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOP2A gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M038544:  view genomic region     (about GC identifiers)

Start:
38,544,768 bp from pter      End:
38,574,202 bp from pter
Size:
29,435 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TOP2A_HUMAN, P11388 (See protein sequence)
Recommended Name: DNA topoisomerase 2-alpha  
Size: 1531 amino acids; 174385 Da
Cofactor: Magnesium. Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and
the DNA. Can also accept other divalent metal cations, such as Mn(2+) and Ca(2+) (Probable)
Subunit: Homodimer. Interacts with COPS5
Subcellular location: Cytoplasm. Nucleus, nucleoplasm. Note=Generally located in the nucleoplasm
Miscellaneous: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas
prokaryotic enzymes relax only negative supercoils
4 PDB 3D structures from and Proteopedia for TOP2A:
1LWZ (3D)        1ZXM (3D)        1ZXN (3D)        4FM9 (3D)    
Secondary accessions: B2RTS1 Q71UN1 Q71UQ5 Q9HB24 Q9HB25 Q9HB26 Q9UP44 Q9UQP9
Alternative splicing: 4 isoforms:  P11388-1   P11388-2   P11388-3   P11388-4   

Explore the universe of human proteins at neXtProt for TOP2A: NX_P11388

Explore proteomics data for TOP2A at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation has no effect on catalytic activity. However, phosphorylation at Ser-1106 by CSNK1D/CK1 promotes
    DNA cleavable complex formation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P11388

  • 4/62 DME Specific Peptides for TOP2A (P11388) (see all 62)
     VVKKKNK  FDSQTKE  DDRKEWL  MIMTDQD 

    TOP2A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TOP2A Protein Expression
    REFSEQ proteins: NP_001058.2  
    ENSEMBL proteins: 
     ENSP00000411532   ENSP00000464055   ENSP00000462908  
    Reactome Protein details: P11388
    Human Recombinant Protein Products for TOP2A: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TOP2A
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TOP2A
    GenScript Custom Purified and Recombinant Proteins Services for TOP2A
    Novus Biologicals TOP2A Protein
    Novus Biologicals TOP2A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000228colocalizes with nuclear chromosome IDA9049244
    GO:0000793condensed chromosome ----
    GO:0000795synaptonemal complex IBA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--

    TOP2A for ontologies           About GeneDecksing



    TOP2A Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TOP2A
    R&D Systems Antibodies for TOP2A
    Cell Signaling Technology (CST) Antibodies for TOP2A 
    OriGene Antibodies for TOP2A
    OriGene Custom Antibody Services for TOP2A
    GenScript Custom Superior Antibodies Services for TOP2A
    Novus Biologicals TOP2A Antibodies
    Abcam antibodies for TOP2A
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for TOP2A
    LSBio Antibodies in human, mouse, rat for TOP2A 

    Assay Products for TOP2A: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TOP2A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TOP2A
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/14 InterPro protein domains (see all 14):
     IPR002205 Topo_IIA_A/C
     IPR018522 TopoIIA_CS
     IPR013758 Topo_IIA_A/C_ab
     IPR012542 DTHCT
     IPR003594 HATPase_ATP-bd

    Graphical View of Domain Structure for InterPro Entry P11388

    ProtoNet protein and cluster: P11388

    5/6 Blocks protein domains (see all 6):
    IPB001154 Topoisomerase II signature
    IPB002205 DNA gyrase/topoisomerase IV
    IPB003594 ATP-binding region
    IPB003957 CCAAT-binding transcription factor subunit A signature
    IPB011558 DNA topoisomerase


    UniProtKB/Swiss-Prot: TOP2A_HUMAN, P11388
    Similarity: Belongs to the type II topoisomerase family
    Similarity: Contains 1 Toprim domain


    TOP2A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TOP2A_HUMAN, P11388
    Function: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands.
    Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of
    daughter chromosomes
    Catalytic activity: ATP-dependent breakage, passage and rejoining of double-stranded DNA
    Enzyme regulation: Specifically inhibited by the intercalating agent amsacrine

         Genatlas biochemistry entry for TOP2A:
    DNA topoisomerase II alpha (170kDa),ubiquitous,markely upregulated in proliferating cells,catalyzing the ATP
    dependent breakage and rejoining of double strand of DNA,relaxing both positively and negatively supercoiled
    DNA,inhibited by Rb during cell cycle,target of several drugs widely used in the treatment of human
    cancers,including a variant associated with drug resistance,deleted or amplified simultaneously with ERBB2 in
    breast cancers

         Enzyme Number (IUBMB): EC 5.99.1.31 2

         Gene Ontology (GO): 5/16 molecular function terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA--
    GO:0003677DNA binding IDA10788521
    GO:0003682chromatin binding IDA9049244
    GO:0003918DNA topoisomerase type II (ATP-hydrolyzing) activity IDA16611985
    GO:0005080protein kinase C binding IPI16611985
         
    TOP2A for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for TOP2A:
     Increased cell death HMECs cel  Increased gamma-H2AX phosphory  Increased number of cells in m  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TOP2A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TOP2A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TOP2A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TOP2A 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TOP2A
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate TOP2A (see all 29):
    hsa-miR-548j hsa-miR-548i hsa-miR-520d-5p hsa-miR-548k hsa-miR-16-1* hsa-miR-548l hsa-miR-144 hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidTOP2A 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TOP2A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOP2A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TOP2A
    Sirion Biotech Customized adenovirus for overexpression of TOP2A

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TOP2A (see all 5)
    OriGene ORF clones in mouse, rat for TOP2A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TOP2A (NM_001067)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOP2A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOP2A

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TOP2A
    Search LifeMap BioReagents cell lines for TOP2A
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOP2A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TOP2A About   (see all 13)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell cycle Transition and termination of DNA replacation
    Cell cycle Transition and termination of DNA replication0.95
    Cell cycle Transition and termination of DNA replacation0.95
    2Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    3Mitotic G1-G1/S phases
    Mitotic G1-G1/S phases0.80
    4Cell cycle Chromosome condensation in prometaphase
    Cell cycle Chromosome condensation in prometaphase1.00
    5Doxorubicin Pathway, Pharmacokinetics
    Doxorubicin Pathway (Cancer Cell), Pharmacodynamics0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for TOP2A
        Cell cycle Transition and termination of DNA replacation
    Meiosis
    Proteolysis Putative SUMO-1 pathway
    Cell cycle Chromosome condensation in prometaphase


    1 Cell Signaling Technology (CST) Pathway for TOP2A
        Chromatin Regulation / Acetylation

    3 GeneGo (Thomson Reuters) Pathways for TOP2A
        Cell cycle Chromosome condensation in prometaphase
    Proteolysis Putative SUMO-1 pathway
    Cell cycle Transition and termination of DNA replication

    3 BioSystems Pathways for TOP2A
        Gastric cancer network 1
    Gastric cancer network 2
    Integrated Pancreatic Cancer Pathway

    4        Reactome Pathways for TOP2A
        Mitotic G1-G1/S phases
    G0 and Early G1
    Cell Cycle
    Cell Cycle, Mitotic

    2 PharmGKB Pathways for TOP2A
        Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
    Etoposide Pathway, Pharmacokinetics/Pharmacodynamics


    TOP2A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TOP2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/118 Interacting proteins for TOP2A (P113881, 2, 3 ENSP000004115324) via UniProtKB, MINT, STRING, and/or I2D (see all 118)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3EP684313, ENSP000003535814I2D: score=1 STRING: ENSP00000353581
    HIST1H3AP684313I2D: score=1 
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0000712resolution of meiotic recombination intermediates IBA--
    GO:0000819sister chromatid segregation IBA--
    GO:0006260DNA replication NAS15504738
    GO:0006261DNA-dependent DNA replication IBA--

    TOP2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TOP2A for compounds           About GeneDecksing

    EMD Millipore small molecules for TOP2A:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for TOP2A

    Compounds for TOP2A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CPT 11DNA topoisomerase I inhibitor; antitumor[100286-90-6]
    Doxorubicin hydrochlorideAntitumor antibiotic agent. Inhibits DNA topoisomerase II[25316-40-9]
    EtoposideTopoisomerase II inhibitor[33419-42-0]
    SN 38DNA topoisomerase I inhibitor; antitumor[86639-52-3]
    CamptothecinDNA topoisomerase inhibitor[7689-03-4]

    1 HMDB Compound for TOP2A    About this table
    CompoundSynonyms CAS #PubMed Ids
    LevofloxacinFloxin (see all 5)100986-85-4--

    10/24 DrugBank Compounds for TOP2A (see all 24)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DexrazoxaneDesrazoxane (see all 7)24584-09-6targetinhibitor11984069 17652819 11332155 17115008 10194547 11752352 11179439 11046078 12911317
    AmsacrineAcridinyl Anisidide (see all 3)51264-14-3targetinhibitor1311390 11473732 11716434 10691026 11752352 11006484 1322791
    MitoxantroneMitoxanthrone (see all 2)65271-80-9targetinhibitor18687447 11278845 9631585 11752352 9494516 11004693 10451375
    DoxorubicinAdria (see all 4)23214-92-8targetinhibitor17016621 17351394 17578914 11752352 17010609 17089011
    EtoposideEPEG (see all 4)33419-42-0targetinhibitor17361331 17514873 16271071 11752352 16309315 16377807
    IdarubicinIdarubicin Hcl (see all 5)58957-92-9targetinhibitor10203104 11836027 11752352 10523799 12034365 8036155
    Podofilox-- 477-47-4targetinhibitor16061385 1331331 11752352 1334447 10783066 1845848
    TeniposideTeniposido [INN-Spanish] (see all 2)29767-20-2targetinhibitor16480143 17361331 17514873 8702194 16271071 11752352
    CiprofloxacinCiprofloxacin dihydrochloride (see all 5)85721-33-1targetinhibitor3015015 11752352 1323952
    Enoxacin-- 74011-58-8targetinhibitor18471102 11752352 10089819

    10/49 Novoseek inferred chemical compound relationships for TOP2A gene (see all 49)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amsacrine 86 19 8980384 (2), 8137294 (1), 8194167 (1), 8823806 (1) (see all 13)
    etoposide 78.4 43 7641205 (3), 8996519 (2), 10969596 (2), 18206427 (2) (see all 32)
    azatoxin 78.2 2 7763310 (2)
    mitoxantrone 72.7 10 8980384 (2), 18665175 (1), 17578914 (1), 11278845 (1) (see all 7)
    doxorubicin 68.2 29 8996519 (2), 15486187 (2), 19620488 (2), 8823806 (1) (see all 21)
    trastuzumab 63.4 6 18078328 (1), 19914538 (1), 15762277 (1), 17089011 (1) (see all 5)
    teniposide 61.4 9 7641205 (3), 8980384 (2), 8548781 (1), 9426516 (1) (see all 5)
    camptothecin 56.4 4 7961822 (1), 14973057 (1), 11205246 (1)
    (glc)4 51.2 12 8041119 (3), 8980384 (2)
    adriamycin 47.5 8 9494516 (2), 7805045 (2), 18401528 (1), 8615623 (1)

    Search CenterWatch for drugs/clinical trials and news about TOP2A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TOP2A gene: 
    NM_001067.3  

    Unigene Cluster for TOP2A:

    Topoisomerase (DNA) II alpha 170kDa
    Hs.156346  [show with all ESTs]
    Unigene Representative Sequence: NM_001067
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000423485(uc002huq.3 uc002hur.1) ENST00000577541 ENST00000578412
    ENST00000577706 ENST00000581055
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TOP2A
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate TOP2A (see all 29):
    hsa-miR-548j hsa-miR-548i hsa-miR-520d-5p hsa-miR-548k hsa-miR-16-1* hsa-miR-548l hsa-miR-144 hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidTOP2A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TOP2A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOP2A
    Clone
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    OriGene clones in human, mouse for TOP2A (see all 5)
    OriGene ORF clones in mouse, rat for TOP2A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TOP2A (NM_001067)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOP2A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOP2A
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TOP2A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TOP2A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOP2A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOP2A

    Additional mRNA sequence: 

    AK024080.1 BC013429.1 BC062677.1 BC140791.1 J04088.1 L47276.1 L47277.1 

    21 DOTS entries:

    DT.99953788  DT.451782  DT.95300834  DT.99932666  DT.100683187  DT.100689464  DT.100825552  DT.100825545 
    DT.120991746  DT.91761832  DT.100038117  DT.100825557  DT.91761835  DT.95282052  DT.95300818  DT.100648081 
    DT.100825546  DT.102832750  DT.120991718  DT.40106389  DT.120991769 

    24/471 AceView cDNA sequences (see all 471):

    CF785876 AI613495 AU117343 BU164121 CA488771 AI990075 BG110847 BF795918 
    BG168017 AI127486 AI760467 BQ946184 BM987169 BM802577 BM749174 AA306247 
    AU133677 AA809450 BM559052 CB119559 CB159159 AW074313 BQ012547 AK024080 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TOP2A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a ·
    SP1:                                                              -                                                                                         -   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            

    ExUns: 25b ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34a · 34b ^ 35
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for TOP2A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TOP2A expression in normal human tissues (normalized intensities)      TOP2A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCAGCAATG
    TOP2A Expression
    About this image


    TOP2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/43 selected tissues (see all 43) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
             Cerebral Cortex
             brain/midbrain   
     
     Heart (Cardiovascular System)    fully expand to see all 5 entries
             Cardiac Fibroblasts Myocardium
             heart/ventricle   
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Umbilical cord blood-derived mesenchymal stem cells
             mouse/organ system/cardiovascular system   

    See TOP2A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TOP2A

    SOURCE GeneReport for Unigene cluster: Hs.156346
        SABiosciences Expression via Pathway-Focused PCR Arrays including TOP2A: 
              Lung Cancer in human mouse rat
              Cancer Drug Targets in human mouse rat
              Cancer Drug Resistance in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOP2A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TOP2A gene from 10/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Top2a1 , 5 topoisomerase (DNA) II alpha1, 5 87.14(n)1
    90.01(a)1
      11 (62.91 cM)5
    219731  NM_011623.21  NP_035753.21 
     989929435 
    chicken
    (Gallus gallus)
    Aves TOP2A1 topoisomerase (DNA) II alpha 170kDa 73.25(n)
    78.32(a)
      395570  NM_204791.1  NP_990122.1 
    lizard
    (Anolis carolinensis)
    Reptilia TOP2A6
    topoisomerase (DNA) II alpha 170kDa
    71(a)
    1 ↔ 1
    6(70009033-70047926)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985122 hypothetical protein LOC398512 77.65(n)    BC044276.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc08c072 Transcribed sequence with moderate similarity to protein more 76.55(n)    57055348 
    fruit fly
    (Drosophila melanogaster)
    Insecta Top21 , 3 meiosis DNA binding3
    Topoisomerase 21
    60(a)3
    57.54(n)1
    58.87(a)1
      37E13
    352251  NM_057412.31  NP_476760.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F32A11.43
    top-21
    DNA topoisomerase II (N-terminal
    region)3
    Protein TOP-21
    59(a)
    (best of 6)3
    57.7(n)1
    57.89(a)1
      II(13134927-13137287)3
    1748251  NM_064135.21  NP_496536.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TOP21 Top2p 53.19(n)
    47.07(a)
      855636   NP_014311.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TOPII1 DNA topoisomerase 2 53.1(n)
    47.84(a)
      821972  NM_113294.2  NP_189031.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g06997001 hypothetical protein 59.02(n)
    59.09(a)
      4330426  NM_001054368.1  NP_001047833.1 


    ENSEMBL Gene Tree for TOP2A (if available)
    TreeFam Gene Tree for TOP2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TOP2A gene
    TOP2B2  
    2 SIMAP similar genes for TOP2A using alignment to 3 protein entries:     TOP2A_HUMAN (see all proteins):
    TOP2B    topIIb

    TOP2A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/620 SNPs in TOP2A are shown (see all 620)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0075334
    ----see VAR_0075332 R K mis40--------
    VAR_0075324
    ----see VAR_0075322 R Q mis40--------
    rs675609691,2
    C--38553556(-) CATCT-/A/AA  
            
    AAAAA
    1 -- int12NA 4
    rs346677331,2
    C,F--38554288(+) GCCTCA/CCAAAG 1 -- int12Minor allele frequency- C:0.25NA WA 4
    rs1123654941,2
    C,F--38554552(+) GGTTTC/TACCAT 1 -- int11Minor allele frequency- T:0.00CSA 1
    rs711526671,2
    C--38561709(-) GTCTCA/-AAAAA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs681656621,2
    C,F--38565472(-) TACCC-/T/TT  
            
    TTTTT
    1 -- int12NA 4
    rs114565261,2
    C--38575393(+) TTTTT-/TGAGAT 1 -- us2k1 trp30--------
    rs1883916991,2
    --39331481(+) ACATGC/TATATT 1 -- ds50010--------
    rs1123796691,2
    C,F--39331491(+) TTACTG/AATCAA 1 -- ds50011Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for TOP2A (38544768 - 38574202 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TOP2A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833445CNV Loss17160897
    nsv908223CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    2 SABiosciences qBiomarker Copy Number PCR Arrays containing TOP2A:
    Oncogenes & Tumor Suppressor Genes 384HC
    Breast Cancer
    SeqTarget long-range PCR primers for resequencing TOP2A
    DNA2.0 Custom Variant and Variant Library Synthesis for TOP2A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 126430    OMIM disorders: --

    20/95 diseases for TOP2A (see all 95):    About MalaCards
    adenocarcinoma in situ    inverted papilloma    ataxia telangiectasia    malignant peripheral nerve sheath tumor
    hereditary breast cancer    central nervous system lymphoma    benign tumors    bladder carcinoma
    papillary renal cell carcinoma    oral lichen planus    soft tissue sarcoma    seminoma
    craniopharyngioma    cervical adenocarcinoma    merkel cell carcinoma    gallbladder cancer
    neurofibroma    adenoid cystic carcinoma    papilloma    lichen planus

    2 diseases from the University of Copenhagen DISEASES database for TOP2A:
    Breast cancer     Cervix endometriosis

    TOP2A for disorders           About GeneDecksing

    10/75 Novoseek inferred disease relationships for TOP2A gene (see all 75)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 63.8 121 20130985 (4), 15891995 (4), 19945923 (4), 18465341 (3) (see all 55)
    tumors 57.1 162 14978790 (6), 19945923 (6), 14566826 (5), 10469452 (5) (see all 67)
    mpnst 46.3 8 14673046 (3), 16721726 (2), 14508395 (1), 18522746 (1)
    small cell lung cancer 45.2 4 8306338 (1), 9713494 (1), 8041119 (1), 12906927 (1)
    breast carcinoma 44.7 20 15628907 (2), 19886180 (2), 14632728 (2), 17013533 (2) (see all 13)
    carcinoma 42.8 14 10597187 (1), 9310953 (1), 12556100 (1), 15068318 (1) (see all 11)
    malignant peripheral nerve sheath tumors 41.4 1 14673046 (1)
    cancer 38.9 33 14632727 (2), 17363613 (2), 7641205 (2), 10652607 (2) (see all 23)
    leukemia 37.6 13 8914817 (2), 9494516 (2), 7643627 (1), 7873386 (1) (see all 11)
    ovarian carcinoma 36.8 6 15385105 (2), 8172796 (1), 14984957 (1), 9504690 (1) (see all 5)

    Genetic Association Database (GAD): TOP2A
    Human Genome Epidemiology (HuGE) Navigator: TOP2A (9 documents)

    Export disorders for TOP2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TOP2A gene, integrated from 9 sources (see all 694):
    (articles sorted by number of sources associating them with TOP2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association between HER2, TOP2A, and response to anth racycline-based preoperative chemotherapy in high-risk primary breast cancer. (PubMed id 20130985)1, 4, 9 Konecny G.E....Slamon D.J. (2010)
    2. Topoisomerase II alpha and responsiveness of breast cancer to adjuvant chemotherapy. (PubMed id 19401546)1, 4, 9 O'Malley F.P....Pritchard K.I. (2009)
    3. Structural organization of the human TOP2A and TOP2B genes. (PubMed id 9795238)1, 2, 9 Lang A.J.... Cole S.P. (1998)
    4. retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, epirubicin, and fluorouracil: Danish Breast Cancer Cooperative Group. (PubMed id 16234514)1, 7, 9 Knoop A.S....Ejlertsen B. (2005)
    5. Mitotic phosphorylation of DNA topoisomerase II alpha by protein kinase CK2 creates the MPM-2 phosphoepitope on Ser-1469. (PubMed id 10942766)1, 2, 9 Escargueil A.E.... Larsen A.K. (2000)
    6. Outcome of patients with early-stage breast cancer tr eated with doxorubicin-based adjuvant chemotherapy as a function of HER2 and TO P2A status. (PubMed id 19620488)1, 4, 9 Tubbs R....Hayes D.F. (2009)
    7. Use of yeast in the study of anticancer drugs targeting DNA topoisomerases: expression of a functional recombinant human DNA topoisomerase II alpha in yeast. (PubMed id 8393377)1, 2, 9 Wasserman R.A.... Wang J.C. (1993)
    8. Genomic polymorphisms provide prognostic information in intermediate-risk acute myeloblastic leukemia. (PubMed id 16507781)1, 4, 9 Monzo M....Sierra J. (2006)
    9. Characterization of human NSCLC cell line with innate etoposide-resistance mediated by cytoplasmic localization of topoisomerase II alpha. (PubMed id 16271071)1, 7, 9 de Lucio B....Barrera-Rodriguez R. (2005)
    10. The structure of DNA-bound human topoisomerase II alpha: conformational mechanisms for coordinating inter-subunit interactions with DNA cleavage. (PubMed id 22841979)1, 2 Wendorff T.J.... Berger J.M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7153 HGNC: 11989 AceView: TOP2A Ensembl:ENSG00000131747 euGenes: HUgn7153
    ECgene: TOP2A H-InvDB: TOP2A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TOP2A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TOP2A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TOP2A gene:
    Search GeneIP for patents involving TOP2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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