Aliases for TOP2A Gene
External Ids for TOP2A Gene
Previous HGNC Symbols for TOP2A Gene
Previous GeneCards Identifiers for TOP2A Gene
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]
GeneCards Summary for TOP2A Gene
TOP2A (Topoisomerase (DNA) II Alpha) is a Protein Coding gene. Diseases associated with TOP2A include Breast Adenoid Cystic Carcinoma and Malignant Peripheral Nerve Sheath Tumor. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and Cell cycle_Chromosome condensation in prometaphase. GO annotations related to this gene include poly(A) RNA binding and protein heterodimerization activity. An important paralog of this gene is MIR4442.
UniProtKB/Swiss-Prot for TOP2A Gene
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity).
Topoisomerases are ubiquitously expressed enzymes that overcome topological problems in genomic DNA, which can result from DNA replication, transcription and repair. Common problems such as knots and tangles are often resolved by topoisomerases.