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TOP1 Gene

protein-coding   GIFtS: 66

GC20P039090
topoisomerase (DNA) I
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for TOP1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
EC 5.99.1.2 3
OTTHUMP00000031713 2
TOPI 2
Descriptions
DNA topoisomerase I 2, 3
topoisomerase (DNA) I 2
topoisomerase I 1
type I DNA topoisomerase 2
External Ids
HGNC: 119861
Entrez Gene: 71502
UniProtKB: P113873
Ensembl: ENSG000001989007
Search outside databases for aliases for TOP1 gene

Previous GC identifers: GC20P039385 GC20P040295 GC20P040342

Summaries
for TOP1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for TOP1:
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of
DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single
strand of DNA which allows the strands to pass through one another, thus altering the topology of
DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and
22. [provided by RefSeq]

UniProtKB/Swiss-Prot: TOP1_HUMAN, P11387
Function: The reaction catalyzed by topoisomerases leads to the conversion of one topological
isomer of DNA to another

Gene Wiki entry for TOP1

Genomic Location
for TOP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the TOP1 gene  

Entrez Gene cytogenetic band: 20q12-q13.1   Ensembl cytogenetic band:  20q12   HGNC cytogenetic band: 20q12-q13.1

TOP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P039090:     (about GC identifiers)

Start:
 39,090,876 bp from pter
End:
 39,186,541 bp from pter
Size:
 95,666 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000020.9  NT_011362.9  

Proteins
for TOP1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: TOP1_HUMAN, P11387 (See protein sequence)
Recommended Name: DNA topoisomerase 1  
Size: 765 amino acids; 90726 Da
Subunit: Monomer. Interacts with SV40 Large T antigen; this interactions allows viral DNA
replication
Subcellular location: Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Diffuse nuclear localization
with some enrichment in nucleoli. On CPT treatment, cleared from nucleoli into nucleoplasm.
Sumolyated forms found in both nucleoplasm and nucleoli
Miscellaneous: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils,
whereas prokaryotic enzymes relax only negative supercoils
Miscellaneous: When a topoisomerase transiently breaks a DNA backbone bond, it simultaneously forms
a protein-DNA link, in which a tyrosyl oxygen in the enzyme is joined to a DNA phosphorus at one
end of the enzyme-severed DNA strand
Sequence caution: Sequence=CAA36834.1; Type=Erroneous gene model prediction;
PDB structures from and Proteopedia :
1A31 (3D)    1A35 (3D)    1A36 (3D)    1EJ9 (3D)    1K4S (3D)    1K4T (3D)    1LPQ (3D)    1NH3 (3D)    
1R49 (3D)    1RR8 (3D)    1RRJ (3D)    1SC7 (3D)    1SEU (3D)    1T8I (3D)    1TL8 (3D)    
Secondary accessions: O43256 Q12855 Q12856 Q15610 Q5TFY3 Q9UJN0

Post-translational modifications:

  • Sumoylated. Lys-117 is the main site of sumoylation. Sumoylation plays a role in partitioning TOP1
    between nucleoli and nucleoplasm. Levels are dramatically increased on camptothecin (CPT)
    treatment1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_003277.1  

    ENSEMBL proteins: 
    ENSP00000384201 ENSP00000354522 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins for TOP1  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Topoisomerase I, Topo I marker for Sumoylation)
    Human Recombinant Proteins from Abnova (TOP1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IDA9049244
    GO:0005654 nucleoplasm IDA9049244
    GO:0005694colocalizes with chromosome IDA9049244
    GO:0005730 nucleolus IDA9049244
    GO:0005737 cytoplasm IEA--
    About this table

    Antibodies for TOP1: 
    Invitrogen Antibodies for TOP1
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibody Arrays and Antibodies for TOP1
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (Topoisomerase I, Topo I marker for Sumoylation), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (TOP1)
    Novus Biologicals Antibodies for TOP1

    Assays for TOP1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for TOP1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/8 InterPro domains/families (see all 8 ):
     IPR013030 TopoI_DNA-bd_mixed-a/b_euk
     IPR008336 TopoI_DNA_bd_euk
     IPR001631 TopoI_C
     IPR018521 TopoI_AS
     IPR014727 TopoI_cat_a/b-sub_euk


       GeneDecks  TOP1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P11387

    ProtoNet protein and cluster: P11387

    2 Blocks protein families:
    IPB001631 Eukaryotic-like DNA topoisomerase I
    IPB008336 Eukaryotic DNA topoisomerase I


    UniProtKB/Swiss-Prot: TOP1_HUMAN, P11387
    Similarity: Belongs to the eukaryotic type I topoisomerase family

    Gene Function
    for TOP1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (TOP1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TOP1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003286

                  Applied Biosystems Silencer® siRNAs for TOP1

                  Sigma-Aldrich siRNA and siRNA Panels for TOP1  
                         Sigma-Aldrich shRNA for TOP1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_003286
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_003286
                                     untagged cDNA clone in CMV expression vector: NM_003286 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_003286

    UniProtKB/Swiss-Prot: TOP1_HUMAN, P11387
    Function: The reaction catalyzed by topoisomerases leads to the conversion of one topological
    isomer of DNA to another
    Catalytic activity: ATP-independent breakage of single-stranded DNA, followed by passage and
    rejoining
    Enzyme regulation: Specifically inhibited by camptothecin (CPT), a plant alkaloid with antitumor
    activity
    Enzyme Number (IUBMB): EC 5.99.1.2 

    Genatlas biochemistry entry for TOP1:
    DNA topoisomerase I,ubiquitous,catalyzing the ATP independent breakage and rejoining of single
    strand of DNA,relaxing negatively supercoiled DNA,involved in DNA repair

    1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Top1):

    lethality-prenatal/perinatal

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682 chromatin binding IDA9049244
    GO:0003917 DNA topoisomerase type I activity IMP17355975
    GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity IEA--
    GO:0005515 protein binding IPI10352183
    About this table

    Pathways & Interactions
    for TOP1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    2 Millipore Pathways for TOP1
     Cell cycle Transition and termination of DNA replacation
     Cell cycle Chromosome condensation in prometaphase

       GeneDecks  TOP1 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  TOP1 


    5/53 Interacting proteins for TOP1 (P113871, 2 ENSP000003545223) via UniProtKB, MINT, and/or STRING (see all 53 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCLP193382, ENSP000003181953MINT-73226 STRING (score=.993)
    TOPBP1Q925472, ENSP000002608103MINT-3379396 STRING (score=.918)
    PARP1P098742, ENSP000003557593MINT-4790124 STRING (score=.862)
    NKX3-1Q998011EBI-876302, EBI-1385894
    APLFQ8IW192MINT-4790124
    About this table

    5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260 DNA replication IEA--
    GO:0006265 DNA topological change IEA--
    GO:0006268 DNA unwinding during replication IEA--
    GO:0012501 programmed cell death NAS17172417
    GO:0016310 phosphorylation NAS17481653
    About this table

    Drugs & Compounds
    for TOP1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for TOP1
    Sigma-Aldrich Small Molecules for TOP1:
    Inhibitor

    Compounds for TOP1 available from Tocris Bioscience
    CompoundAction CAS number
    CPT 11DNA topoisomerase I inhibitor; antitumor[100286-90-6]
    SN 38DNA topoisomerase I inhibitor; antitumor[86639-52-3]
    CamptothecinDNA topoisomerase inhibitor[7689-03-4]
    About this table


    10/24 Novoseek chemical compound relationships for TOP1 gene (see all 24 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    tdp-1 85.71 47 15494395 (6), 15920477 (3), 16793421 (2), 15744309 (2) (see all 20)
    rebeccamycin 85.36 23 11032967 (3), 12901916 (2), 10322124 (2), 11733535 (1) (see all 17)
    saintopin 83.09 29 9203632 (5), 1646001 (3), 7961822 (2), 7890748 (2) (see all 7)
    edotecarin 81.16 6 15929804 (2), 15057663 (1), 16675581 (1), 17089166 (1) (see all 5)
    intoplicine 79.44 8 10630356 (2), 8740721 (1), 8271279 (1), 8232227 (1) (see all 6)
    uce6 79.28 3 9268005 (2), 8395492 (1)
    bn 80915 79.09 7 17984197 (2), 11502875 (2), 14519632 (1), 17322542 (1)
    10,11-methylenedioxycamptothecin 78.92 2 7949099 (1), 2176090 (1)
    karenitecin 77.52 3 11309344 (1), 19318485 (1), 11004678 (1)
    nitidine 76.80 9 8117920 (3), 9174366 (1), 10496978 (1), 12659767 (1) (see all 6)
    About this table


    Transcripts
    for TOP1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (TOP1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TOP1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003286

                  Sigma-Aldrich siRNA and siRNA Panels for TOP1  
                         Sigma-Aldrich shRNA for TOP1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_003286  

    REFSEQ mRNAs for TOP1 gene: 

    NM_003286.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_003286  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_003286
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_003286
                                     untagged cDNA clone in CMV expression vector: NM_003286 

    Additional cDNA sequence: 

    AK225095.1 AK292943.1 AK310508.1 AK310516.1 BC000943.2 BC004475.2 BC039009.1 BC056681.1 
    BC067349.1 BC136297.1 CR590405.1 J03250.1 M27913.1 U07804.1 U07806.1 X16479.2 

    15 DOTS entries:

    DT.97780620  DT.425139  DT.99987653  DT.40209313  DT.99955016  DT.120819606  DT.40261268  DT.75183810 
    DT.95191468  DT.120819634  DT.86840413  DT.95194887  DT.91743457  DT.95191472  DT.95210182 

    24/299 AceView cDNA sequences (see all 299 ):

    AI493041 H65749 BE093859 BC056681 CA438301 AI479910 BF726053 AI859596 
    AA830283 BX403047 CF127017 BU195531 AA371544 BX391491 R00391 BF109124 
    BQ918804 BU686012 BU625720 CA487823 U07804 F07589 BP871306 BC004475 

    highest scoring ESTs for TOP1:

    AA573154 AA588554 AA708654 AA745864 AA826116 AA827288 AI094432 AI127444 AI146384 AI263987 

    Unigene Cluster for TOP1:

    Topoisomerase (DNA) I
    Hs.472737  [show with all ESTs]
    Unigene Representative Sequence: NM_003286


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000404238  ENST00000361337  

    Expression
    for TOP1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    TOP1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for TOP1

    1 / 2 / 3

    7 probe-sets matching TOP1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		1710_s_at2, 3 U95-A 3 1.00 0.71 0.95 0.69 U07804 0.80 0.70 0.75 1
    1030_s_at2, 3 U95-A 3 1.00 0.51 0.97 1.18 U07806 0.80 0.70 0.75 1

    		31680_at2, 3 U95-A 3 0.94 0.40 0.95 1.14 M55630 0.20 0.17 0.18 2

    		208900_s_at2, 3 U133-A 1 1.00 1.00 -- -- AW025108 0.40 0.50 0.45 1

    		208901_s_at2, 3 U133-A 3 1.00 0.56 -- -- J03250 0.60 0.62 0.61 1

    		208900_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		208901_s_at2 U133Plus2 3 1.00 0.56 -- -- -- -- -- -- --
    GeneDecks  TOP1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AATTCCCTTT

    SOURCE GeneReport for Unigene cluster: Hs.472737

    Expression variation in blood from EXPOLDB for TOP1

    Orthologs
    for TOP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for TOP1 gene from 5/24 species (see all 24 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 TOP11   -- topoisomerase (DNA) I 94.25(n)
    98.17(a)    		 477229  XM_534420.2  XP_534420.2 
    chimpanzee
    (Pan troglodytes)    		 TOP11   -- topoisomerase (DNA) I 99.78(n)
    100(a)    		 458252  XM_514649.2  XP_514649.2 
    cow
    (Bos taurus)    		 TOP11   -- topoisomerase (DNA) I 94.25(n)
    98.69(a)    		 534799  XM_614691.3  XP_614691.3 
    rat
    (Rattus norvegicus)    		 Top11   -- topoisomerase (DNA) I 90.72(n)
    97.25(a)    		 64550  NM_022615.1  NP_072137.1 
    mouse
    (Mus musculus)    		 Top11, 5 2 (92.00 cM)5
    		 topoisomerase (DNA) I1, 5 90.85(n)1
    97.25(a)1    		 219691  NM_009408.21  NP_033434.21 
     AA4380955  AI4673345  (see all 33)
    About this table        Species with no ortholog for TOP1

    ENSEMBL Gene Tree for TOP1

    Paralogs
    for TOP1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for TOP1 gene
    TOP1MT2  

    SNPs/Variants
    for TOP1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/412 NCBI SNPs in TOP1 are shown (see all 412 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 114)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 20 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs81246201,2
    		C,F,H39186830(+) CTAGCG/ATAGGT 1 -- ng317Minor allele frequency- A:0.09EU EA WA NA 560
    rs60722781,2
    		H39185841(+) CGCACC/TTGTTA 1 -- ut31 ese34Minor allele frequency- T:0.00EU EA WA 416
    rs61022471,2
    		H39090890(+) ACTTAG/AGCTGT 1 -- ut51 ese34Minor allele frequency- A:0.00EU EA WA 418
    rs60722501,2
    		H39089843(+) AATCAG/TCGGGA 1 -- ng514Minor allele frequency- T:0.00EU EA WA 416
    rs61297571,2
    		H39176120(+) ACCCAG/AAGTTG 1 K/E mis1 ese34Minor allele frequency- A:0.00EU EA WA 420
    --
    rs10419531,2
    		F39185754(+) TCTATA/TTTTTA 1 -- ut311Minor allele frequency- T:0.01MN 184
    --
    rs60722491,2
    		A39089756(+) ccAGCA/GCATTG 1 -- ng510--------
    rs60295421,2
    		H39154551(+) CTGAAG/AGCATC 1 S/G mis1 ese34Minor allele frequency- A:0.00EU EA WA 406
    rs60295451,2
    		C,F,H39162181(+) GAGAGG/AATTGC 1 R/R syn1 ese3 trp37Minor allele frequency- A:0.01EU EA WA NA 562
    rs22237451,2
    		A,C,F,H,O39147283(+) AATAAA/GCATCT 1 -- int112Minor allele frequency- G:0.32NS EU EA WA NA 632
    About this table

    HapMap Linkage Disequilibrium images for TOP1 (up to first 250kb)

    Disorders & Mutations
    for TOP1

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 126420

    UniProtKB/Swiss-Prot: TOP1_HUMAN, P11387

  • A chromosomal aberration involving TOP1 is found in a form of therapy-related
    myelodysplastic syndrome. Translocation t(11;20)(p15;q11) with NUP98

    • 10/92 Novoseek disease relationships for TOP1 gene (see all 92 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    scan1 82.63 13 15920477 (2), 17600775 (1), 17707402 (1), 16935573 (1)
    solid tumor 68.53 35 16807458 (2), 8835290 (1), 9058732 (1), 10021292 (1) (see all 31)
    neutropenia 67.74 4 8611374 (1), 11081458 (1), 15470958 (1), 18347181 (1)
    sclerosis systemic 66.96 44 7615831 (2), 11465716 (2), 19211583 (2), 1319697 (2) (see all 36)
    colon carcinoma 66.08 15 11594758 (2), 1310066 (1), 9321666 (1), 18538108 (1) (see all 14)
    cancer 63.59 163 15735043 (2), 11020283 (2), 12852757 (2), 17493824 (2) (see all 99)
    leukemia p388 62.12 7 9927631 (1), 11205907 (1), 9892183 (1), 11118036 (1) (see all 5)
    small cell lung cancer 61.75 14 17645849 (2), 8853931 (1), 15735665 (1), 8093110 (1) (see all 13)
    ovarian cancer 61.73 28 16462890 (4), 18405948 (2), 9497914 (2), 11774743 (2) (see all 20)
    leukemia 60.57 40 17418582 (2), 1997159 (1), 1848545 (1), 8914817 (1) (see all 36)
    About this table

    Medical News
    for TOP1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    Publications
    for TOP1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/933 PubMed articles for TOP1 gene (see all 933 ):

    Search for TOP1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TOP1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 7150 HGNC: 11986 AceView: TOP1 Ensembl:ENSG00000198900 euGenes: HUgn7150
    ECgene: TOP1 H-InvDB: TOP1

    Other Databases showing TOP1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing TOP1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for TOP1 Genetics and Cytogenetics in Oncology and Haematology

    Licensable Technologies
    for TOP1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for TOP1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for TOP1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for TOP1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for TOP1 Antibodies for TOP1
     Explore super-pooled esiRNAs Proteins for TOP1
     Lentivirus-delivered shRNAs for TOP1 Small molecules for TOP1
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (TOP1)
     Antibodies (TOP1)
     Chimera RNAi (TOP1)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (Topoisomerase I, Topo I marker for Sumoylation)
     Antibodies (Topoisomerase I, Topo I marker for Sumoylation)
     Search OriGene for TOP1
     Tocris compounds for TOP1




     Drugs for TOP1
     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for TOP1

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

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    Developed at the Crown Human Genome Center & Weizmann Institute of Science



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