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Aliases for TOP1 Gene

Aliases for TOP1 Gene

  • Topoisomerase (DNA) I 2 3
  • EC 5.99.1.2 4 63
  • Type I DNA Topoisomerase 3
  • DNA Topoisomerase 1 3
  • DNA Topoisomerase I 4
  • TOPI 3

External Ids for TOP1 Gene

Previous GeneCards Identifiers for TOP1 Gene

  • GC20P039385
  • GC20P040295
  • GC20P040342
  • GC20P039090
  • GC20P039657
  • GC20P036395

Summaries for TOP1 Gene

Entrez Gene Summary for TOP1 Gene

  • This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008]

GeneCards Summary for TOP1 Gene

TOP1 (Topoisomerase (DNA) I) is a Protein Coding gene. Diseases associated with TOP1 include molluscum contagiosum and irinotecan toxicity. Among its related pathways are Integrated Pancreatic Cancer Pathway and Apoptosis and survival Caspase cascade. GO annotations related to this gene include chromatin binding and DNA topoisomerase type II (ATP-hydrolyzing) activity. An important paralog of this gene is TOP1MT.

UniProtKB/Swiss-Prot for TOP1 Gene

  • Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component ARNTL/BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the ARNTL/BMAL1 promoter.

Tocris Summary for TOP1 Gene

  • Topoisomerases are ubiquitously expressed enzymes that overcome topological problems in genomic DNA, which can result from DNA replication, transcription and repair. Common problems such as overwinding (positive supercoiling), knots and tangles are resolved by topoisomerases by catalysing the breaking of one or two strands of DNA. Topoisomerase type I enzymes cut just one strand of the DNA double helix, and hence relax supercoiling of the DNA. Four genes encode Type I topoisomerases, which include nuclear topoisomerase I (TOP1) and mitochondrial topoisomerase I (TOP1MT). Type I enzymes can also be sub-divided into Types A and B based on their different catalytic mechanism for generating single DNA strand breaks. TOP1 and TOP1MT are both type 1B since they form 3'-phosphotyrosyl bonds. Camptothecin is a natural product inhibitor of TOP1 that has led to the discovery of derivatives that are clinically used anti-cancer drugs. Such inhibitors trap the enzyme in a cleavage complex with DNA. Type II topoisomerases (IIA and IIB) are particular important for the disentanglement of DNA, which is overcome by generating double stranded DNA breaks. Dysregulation of type II enzymes can therefore have a potentially significant genotoxic effect. There is a broad range of topoisomerase II inhibitors that are used clinically as anticancer agents.

Gene Wiki entry for TOP1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOP1 Gene

Genomics for TOP1 Gene

Regulatory Elements for TOP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TOP1 Gene

Start:
41,028,818 bp from pter
End:
41,124,487 bp from pter
Size:
95,670 bases
Orientation:
Plus strand

Genomic View for TOP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TOP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOP1 Gene

Proteins for TOP1 Gene

  • Protein details for TOP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11387-TOP1_HUMAN
    Recommended name:
    DNA topoisomerase 1
    Protein Accession:
    P11387
    Secondary Accessions:
    • A8KA78
    • E1P5W3
    • O43256
    • Q12855
    • Q12856
    • Q15610
    • Q5TFY3
    • Q9UJN0

    Protein attributes for TOP1 Gene

    Size:
    765 amino acids
    Molecular mass:
    90726 Da
    Quaternary structure:
    • Monomer. Interacts with SV40 Large T antigen; this interactions allows viral DNA replication.
    Miscellaneous:
    • Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils
    SequenceCaution:
    • Sequence=CAA36834.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TOP1 Gene

neXtProt entry for TOP1 Gene

Proteomics data for TOP1 Gene at MOPED

Post-translational modifications for TOP1 Gene

  • Phosphorylation at Ser-506 by CK2 increases binding to supercoiled DNA and sensitivity to camptothecin.
  • Sumoylated. Lys-117 is the main site of sumoylation. Sumoylation plays a role in partitioning TOP1 between nucleoli and nucleoplasm. Levels are dramatically increased on camptothecin (CPT) treatment.
  • Ubiquitination at Lys223, Lys245, Lys252, Lys262, Lys354, Lys484, Lys549, Lys587, Lys642, and Lys742
  • Modification sites at PhosphoSitePlus

Other Protein References for TOP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for TOP1 Gene

Suggested Antigen Peptide Sequences for TOP1 Gene

Graphical View of Domain Structure for InterPro Entry

P11387

UniProtKB/Swiss-Prot:

TOP1_HUMAN :
  • P11387
Family:
  • Belongs to the type IB topoisomerase family.
genes like me logo Genes that share domains with TOP1: view

No data available for Gene Families for TOP1 Gene

Function for TOP1 Gene

Molecular function for TOP1 Gene

GENATLAS Biochemistry: DNA topoisomerase I,ubiquitous,catalyzing the ATP independent breakage and rejoining of single strand of DNA,relaxing negatively supercoiled DNA,involved in DNA repair
UniProtKB/Swiss-Prot CatalyticActivity: ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
UniProtKB/Swiss-Prot EnzymeRegulation: Specifically inhibited by camptothecin (CPT), a plant alkaloid with antitumor activity
UniProtKB/Swiss-Prot Function: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component ARNTL/BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the ARNTL/BMAL1 promoter.

Enzyme Numbers (IUBMB) for TOP1 Gene

Gene Ontology (GO) - Molecular Function for TOP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001046 core promoter sequence-specific DNA binding IDA 22904072
GO:0003677 DNA binding IDA 17355975
GO:0003682 chromatin binding IDA 9049244
GO:0003917 DNA topoisomerase type I activity IMP 17355975
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity IEA --
genes like me logo Genes that share ontologies with TOP1: view

Phenotypes for TOP1 Gene

MGI mutant phenotypes for TOP1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with TOP1: view

Animal Models for TOP1 Gene

MGI Knock Outs for TOP1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TOP1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for TOP1 Gene

Localization for TOP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOP1 Gene

Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Diffuse nuclear localization with some enrichment in nucleoli. On CPT treatment, cleared from nucleoli into nucleoplasm. Sumolyated forms found in both nucleoplasm and nucleoli.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TOP1 Gene COMPARTMENTS Subcellular localization image for TOP1 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2
chloroplast 1
cytoskeleton 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TOP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 colocalizes_with nuclear chromosome IDA 9049244
GO:0000932 cytoplasmic mRNA processing body IDA 12878161
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA 9049244
GO:0005694 chromosome --
genes like me logo Genes that share ontologies with TOP1: view

Pathways for TOP1 Gene

genes like me logo Genes that share pathways with TOP1: view

Pathways by source for TOP1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TOP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006260 DNA replication IBA --
GO:0006265 DNA topological change IDA 14594810
GO:0006338 chromatin remodeling IMP 22904072
GO:0007059 chromosome segregation IBA --
genes like me logo Genes that share ontologies with TOP1: view

Compounds for TOP1 Gene

Compound Products

(5) Tocris Compounds for TOP1 Gene

Compound Action Cas Number
beta-Lapachone DNA topoisomerase I inhibitor [4707-32-8]
CPT 11 DNA topoisomerase I inhibitor; antitumor [100286-90-6]
Doxorubicin hydrochloride Antitumor antibiotic agent. Inhibits DNA topoisomerase II [25316-40-9]
SN 38 DNA topoisomerase I inhibitor; antitumor [86639-52-3]
Trovafloxacin mesylate Antibiotic; inhibits bacterial DNA synthesis [147059-75-4]

(20) ApexBio Compounds for TOP1 Gene

Compound Action Cas Number
4-Demethylepipodophyllotoxin key intermediate compound for the preparation of podophyllotoxin-type anti-cancer drugs [6559-91-7]
Amonafide DNA intercalator and Topo II (topoisomerase II) inhibitor [69408-81-7]
Amrubicin Topoisomerase II inhibitor, anthracycline agent [110267-81-7]
Camptothecin prototypic DNA topoisomerase I inhibitor. [7689-3-4]
Deferasirox Fe3+ chelate rationally-designed oral iron chelator. [554435-83-5]
Dexrazoxane HCl (ICRF-187, ADR-529) cardioprotective agent. [149003-01-0]
Doxorubicin DNA topoisomerase I inhibitor [23214-92-8]
Doxorubicin (Adriamycin) HCl Antitumor antibiotic agent, inhibits DNA topoisomerase II. [25316-40-9]
Ellagic acid ATP-competitive inhibitor of casein kinase 2 (CK2) [476-66-4]
Epirubicin HCl Antibiotic antitumor agent. [56390-09-1]
Etoposide Topoisomerase II inhibitor [33419-42-0]
Gatifloxacin Fluoroquinolone antibiotic. [112811-59-3]
Genistein Phytoestrogen with a wide range of biological actions. [446-72-0]
Genz-644282 non-camptothecin inhibitor of topoisomerase I [529488-28-6]
Idarubicin HCl anthracycline and an analog of daunorubicin [57852-57-0]
Irinotecan isomer of the Topo I inhibitor Irinotecan [97682-44-5]
Ofloxacin fluorinated quinolone antibacterial. [82419-36-1]
Teniposide glycoside-derivative of podophyllotoxin. [29767-20-2]
TH-302 newly developed antineoplastic drug [918633-87-1]
Voreloxin Hydrochloride inhibitor of Topo II. [175519-16-1]

(7) Drugbank Compounds for TOP1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM
target
4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE
target
Camptothecin
  • (+)-camptothecin
7689-03-4 target
Irinotecan
  • Camptothecin-11
100286-90-6 target inhibitor
Lucanthone
  • 1-((2-(Diethylamino)ethyl)amino)-4-methylthioxanthen-9-one
479-50-5 target inhibitor

(124) Novoseek inferred chemical compound relationships for TOP1 Gene

Compound -log(P) Hits PubMed IDs
camptothecin 98 278
topotecan 96 138
irinotecan 92.1 123
9-aminocamptothecin 90.7 26
sn 38 88.5 29

(1) PharmGKB related drug/compound annotations for TOP1 Gene

Drug/compound Annotation
irinotecan CA
genes like me logo Genes that share compounds with TOP1: view

Transcripts for TOP1 Gene

mRNA/cDNA for TOP1 Gene

Unigene Clusters for TOP1 Gene

Topoisomerase (DNA) I:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TOP1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TOP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOP1 Gene

No ASD Table

Relevant External Links for TOP1 Gene

GeneLoc Exon Structure for
TOP1
ECgene alternative splicing isoforms for
TOP1

Expression for TOP1 Gene

mRNA expression in normal human tissues for TOP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TOP1 Gene

SOURCE GeneReport for Unigene cluster for TOP1 Gene Hs.472737

mRNA Expression by UniProt/SwissProt for TOP1 Gene

P11387-TOP1_HUMAN
Tissue specificity: Endothelial cells.
genes like me logo Genes that share expressions with TOP1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TOP1 Gene

Orthologs for TOP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TOP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOP1 35
  • 99.78 (n)
  • 100 (a)
TOP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TOP1 35
  • 93.86 (n)
  • 97.91 (a)
TOP1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TOP 36
  • 98 (a)
OneToOne
TOP1 35
  • 93.81 (n)
  • 97.25 (a)
mouse
(Mus musculus)
Mammalia Top1 35
  • 90.85 (n)
  • 97.25 (a)
Top1 16
Top1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TOP1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TOP1 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Top1 35
  • 90.72 (n)
  • 97.25 (a)
chicken
(Gallus gallus)
Aves TOP1 35
  • 83.25 (n)
  • 92.26 (a)
TOP1 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TOP1 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.62 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496521 35
  • 74.83 (n)
  • 82.78 (a)
zebrafish
(Danio rerio)
Actinopterygii top1 36
  • 72 (a)
OneToMany
TOP1 (1 of 3) 36
  • 62 (a)
OneToMany
top1l 35
  • 74.66 (n)
  • 80.93 (a)
top1l 36
  • 82 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004078 35
  • 63.92 (n)
  • 69.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta Top1 35
  • 65.2 (n)
  • 69.23 (a)
Top1 36
  • 45 (a)
OneToMany
Top1 37
  • 67 (a)
worm
(Caenorhabditis elegans)
Secernentea top-1 35
  • 63.29 (n)
  • 66.67 (a)
top-1 36
  • 49 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL008C 35
  • 57.23 (n)
  • 52.6 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOP1 35
  • 56.88 (n)
  • 53.83 (a)
TOP1 36
  • 39 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C06116g 35
  • 55.49 (n)
  • 52.44 (a)
soybean
(Glycine max)
eudicotyledons Gma.6815 35
thale cress
(Arabidopsis thaliana)
eudicotyledons TOP1BETA 35
  • 55.58 (n)
  • 49.44 (a)
corn
(Zea mays)
Liliopsida Zm.5813 35
rice
(Oryza sativa)
Liliopsida Os08g0154600 35
  • 55.25 (n)
  • 51.11 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.26671 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09118 35
  • 55.54 (n)
  • 49.27 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes top1 35
  • 56.41 (n)
  • 53.47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8887 36
  • 63 (a)
OneToMany
Species with no ortholog for TOP1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for TOP1 Gene

ENSEMBL:
Gene Tree for TOP1 (if available)
TreeFam:
Gene Tree for TOP1 (if available)

Paralogs for TOP1 Gene

Paralogs for TOP1 Gene

Selected SIMAP similar genes for TOP1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for TOP1 Gene

genes like me logo Genes that share paralogs with TOP1: view

Variants for TOP1 Gene

Sequence variations from dbSNP and Humsavar for TOP1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs735114 -- 41,077,569(-) GTAAA(A/C)CAACA intron-variant
rs1546915 -- 41,094,216(-) TTTAC(A/G)TAACA intron-variant
rs1997833 -- 41,061,702(+) TATGT(C/T)TAATT intron-variant
rs2064402 -- 41,032,356(+) TTTAT(A/T)TTTAA intron-variant
rs2076574 -- 41,092,733(-) CCTGA(C/T)GCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TOP1 Gene

Variant ID Type Subtype PubMed ID
nsv833982 CNV Loss 17160897
nsv833983 CNV Loss 17160897

Relevant External Links for TOP1 Gene

HapMap Linkage Disequilibrium report
TOP1
Human Gene Mutation Database (HGMD)
TOP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOP1 Gene

Disorders for TOP1 Gene

UniProtKB/Swiss-Prot

TOP1_HUMAN
  • Note=A chromosomal aberration involving TOP1 is found in a form of therapy-related myelodysplastic syndrome. Translocation t(11;20)(p15;q11) with NUP98.

(93) Novoseek inferred disease relationships for TOP1 Gene

Disease -log(P) Hits PubMed IDs
scan1 81.7 5
solid tumor 67.7 33
neutropenia 67.3 5
sclerosis systemic 66.6 43
colon carcinoma 66.3 16

Relevant External Links for TOP1

Genetic Association Database (GAD)
TOP1
Human Genome Epidemiology (HuGE) Navigator
TOP1
genes like me logo Genes that share disorders with TOP1: view

Publications for TOP1 Gene

  1. Mutation at the catalytic site of topoisomerase I in CEM/C2, a human leukemia cell line resistant to camptothecin. (PMID: 7882333) Fujimori A. … Pommier Y. (Cancer Res. 1995) 3 4 23
  2. Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites. (PMID: 1849260) Tamura H. … Nishikawa K. (Nucleic Acids Res. 1991) 3 4 23
  3. Sumoylation of topoisomerase I is involved in its partitioning between nucleoli and nucleoplasm and its clearing from nucleoli in response to camptothecin. (PMID: 12149243) Rallabhandi P. … D'Arpa P. (J. Biol. Chem. 2002) 3 4 23
  4. 8-Oxoguanine rearranges the active site of human topoisomerase I. (PMID: 12209008) Lesher D.T. … Redinbo M.R. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4 23
  5. The mechanism of topoisomerase I poisoning by a camptothecin analog. (PMID: 12426403) Staker B.L. … Stewart L. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4 23

Products for TOP1 Gene

Sources for TOP1 Gene

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