Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TOP1 Gene

protein-coding   GIFtS: 68
GCID: GC20P039657

Topoisomerase (DNA) I

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Topoisomerase (DNA) I1 2
EC 5.99.1.23 8
TOPI2
DNA Topoisomerase 12
Type I DNA Topoisomerase2
DNA Topoisomerase I3

External Ids:    HGNC: 119861   Entrez Gene: 71502   Ensembl: ENSG000001989007   OMIM: 1264205   UniProtKB: P113873   

Export aliases for TOP1 gene to outside databases

Previous GC identifers: GC20P039385 GC20P040295 GC20P040342 GC20P039090 GC20P036395


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TOP1 Gene:
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during
transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows
the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome
20 and has pseudogenes which reside on chromosomes 1 and 22. (provided by RefSeq, Jul 2008)

GeneCards Summary for TOP1 Gene: 
TOP1 (topoisomerase (DNA) I) is a protein-coding gene. Diseases associated with TOP1 include scleroderma, and molluscum contagiosum, and among its related super-pathways are Cell cycle Transition and termination of DNA replication and Irinotecan Pathway, Pharmacokinetics. GO annotations related to this gene include chromatin binding and DNA topoisomerase type II (ATP-hydrolyzing) activity. An important paralog of this gene is TOP1MT.

UniProtKB/Swiss-Prot: TOP1_HUMAN, P11387
Function: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and
transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand
break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the
catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and
the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus
removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to
expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Regulates the
alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells

summary for TOP1 Gene:
Topoisomerases are ubiquitously expressed enzymes that overcome topological problems in genomic DNA, which
can result from DNA replication, transcription and repair. Common problems such as overwinding (positive
supercoiling), knots and tangles are resolved by topoisomerases by catalysing the breaking of one or two
strands of DNA. Topoisomerase type I enzymes cut just one strand of the DNA double helix, and hence relax
supercoiling of the DNA. Four genes encode Type I topoisomerases, which include nuclear topoisomerase I
(TOP1) and mitochondrial topoisomerase I (TOP1MT). Type I enzymes can also be sub-divided into Types A and B
based on their different catalytic mechanism for generating single DNA strand breaks. TOP1 and TOP1MT are
both type 1B since they form 3'-phosphotyrosyl bonds. Camptothecin is a natural product inhibitor of TOP1
that has led to the discovery of derivatives that are clinically used anti-cancer drugs. Such inhibitors
trap the enzyme in a cleavage complex with DNA. Type II topoisomerases (IIA and IIB) are particular
important for the disentanglement of DNA, which is overcome by generating double stranded DNA breaks.
Dysregulation of type II enzymes can therefore have a potentially significant genotoxic effect. There is a
broad range of topoisomerase II inhibitors that are used clinically as anticancer agents.

Gene Wiki entry for TOP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TOP1 gene promoter:
         CREB   c-Fos   Sp1   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TOP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TOP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12-q13.1   Ensembl cytogenetic band:  20q12   HGNC cytogenetic band: 20q12-q13.1

TOP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOP1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P039657:  view genomic region     (about GC identifiers)

Start:
39,657,458 bp from pter      End:
39,753,127 bp from pter
Size:
95,670 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TOP1_HUMAN, P11387 (See protein sequence)
Recommended Name: DNA topoisomerase 1  
Size: 765 amino acids; 90726 Da
Subunit: Monomer. Interacts with SV40 Large T antigen; this interactions allows viral DNA replication
Subcellular location: Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Diffuse nuclear localization with some
enrichment in nucleoli. On CPT treatment, cleared from nucleoli into nucleoplasm. Sumolyated forms found in both
nucleoplasm and nucleoli
Miscellaneous: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas
prokaryotic enzymes relax only negative supercoils
Sequence caution: Sequence=CAA36834.1; Type=Erroneous gene model prediction;
6/15 PDB 3D structures from and Proteopedia for TOP1 (see all 15):
1A31 (3D)        1A35 (3D)        1A36 (3D)        1EJ9 (3D)        1K4S (3D)        1K4T (3D)    
Secondary accessions: A8KA78 E1P5W3 O43256 Q12855 Q12856 Q15610 Q5TFY3 Q9UJN0

Explore the universe of human proteins at neXtProt for TOP1: NX_P11387

Explore proteomics data for TOP1 at MOPED 

Post-translational modifications:

  • UniProtKB: Sumoylated. Lys-117 is the main site of sumoylation. Sumoylation plays a role in partitioning TOP1 between
    nucleoli and nucleoplasm. Levels are dramatically increased on camptothecin (CPT) treatment
  • UniProtKB: Phosphorylation at Ser-506 by CK2 increases binding to supercoiled DNA and sensitivity to camptothecin
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P11387

  • 4/27 DME Specific Peptides for TOP1 (P11387) (see all 27)
     DFLGKDS  VKFYYDG  KHKDKHK  LRAGNEK 

    TOP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TOP1 Protein Expression
    REFSEQ proteins: NP_003277.1  
    ENSEMBL proteins: 
     ENSP00000354522  

    Human Recombinant Protein Products for TOP1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TOP1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TOP1
    GenScript Custom Purified and Recombinant Proteins Services for TOP1
    Novus Biologicals TOP1 Protein
    Novus Biologicals TOP1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for TOP1
    Cloud-Clone Corp. Proteins for TOP1 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000228colocalizes with nuclear chromosome IDA9049244
    GO:0000932cytoplasmic mRNA processing body IDA12878161
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm IDA9049244
    GO:0005694chromosome ----

    TOP1 for ontologies           About GeneDecksing



    TOP1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TOP1
    OriGene Custom Antibody Services for TOP1
    GenScript Custom Superior Antibodies Services for TOP1
    Novus Biologicals TOP1 Antibodies
    Abcam antibodies for TOP1
    Cloud-Clone Corp. Antibodies for TOP1 
    ThermoFisher Antibodies for TOP1
    LSBio Antibodies in human, mouse, rat for TOP1 

    Assay Products for TOP1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TOP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TOP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TOP1 
    Cloud-Clone Corp. CLIAs for TOP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/12 InterPro protein domains (see all 12):
     IPR013030 TopoI_DNA-bd_mixed-a/b_euk
     IPR008336 TopoI_DNA-bd_euk
     IPR001631 TopoI
     IPR018521 TopoI_AS
     IPR014727 TopoI_cat_a/b-sub_euk

    Graphical View of Domain Structure for InterPro Entry P11387

    ProtoNet protein and cluster: P11387

    2 Blocks protein domains:
    IPB001631 Eukaryotic-like DNA topoisomerase I
    IPB008336 Eukaryotic DNA topoisomerase I


    UniProtKB/Swiss-Prot: TOP1_HUMAN, P11387
    Similarity: Belongs to the type IB topoisomerase family


    TOP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TOP1_HUMAN, P11387
    Function: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and
    transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand
    break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the
    catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and
    the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus
    removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to
    expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Regulates the
    alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells
    Catalytic activity: ATP-independent breakage of single-stranded DNA, followed by passage and rejoining
    Enzyme regulation: Specifically inhibited by camptothecin (CPT), a plant alkaloid with antitumor activity

         Genatlas biochemistry entry for TOP1:
    DNA topoisomerase I,ubiquitous,catalyzing the ATP independent breakage and rejoining of single strand of
    DNA,relaxing negatively supercoiled DNA,involved in DNA repair

         Enzyme Number (IUBMB): EC 5.99.1.21 2

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA17355975
    GO:0003682chromatin binding IDA9049244
    GO:0003917DNA topoisomerase type I activity IMP17355975
    GO:0003918DNA topoisomerase type II (ATP-hydrolyzing) activity IEA--
    GO:0005515protein binding IPI10352183
         
    TOP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Top1):
     mortality/aging 

    TOP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Top1tm1Unc for TOP1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TOP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TOP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TOP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TOP1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TOP1
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate TOP1 (see all 52):
    hsa-miR-549 hsa-miR-4307 hsa-miR-3607-3p hsa-miR-1197 hsa-miR-139-5p hsa-miR-25 hsa-miR-485-3p hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidTOP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TOP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TOP1
    Sirion Biotech Customized adenovirus for overexpression of TOP1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TOP1 (see all 5)
    OriGene ORF clones in mouse, rat for TOP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TOP1 (NM_003286)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOP1
    Sirion Biotech Customized lentivirus for stable overexpression of TOP1 
                         Customized lentivirus expression plasmids for stable overexpression of TOP1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TOP1
    Search LifeMap BioReagents cell lines for TOP1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TOP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cell cycle Transition and termination of DNA replacation
    Cell cycle Transition and termination of DNA replication0.95
    Cell cycle Transition and termination of DNA replacation0.95
    2Irinotecan Pathway, Pharmacokinetics
    Irinotecan Pathway, Pharmacodynamics0.50
    3Cell cycle Chromosome condensation in prometaphase
    Cell cycle Chromosome condensation in prometaphase1.00
    4Apoptosis and survival Caspase cascade
    Caspase cascade in apoptosis0.42
    5Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for TOP1
        Cell cycle Transition and termination of DNA replacation
    Cell cycle Chromosome condensation in prometaphase


    2 GeneGo (Thomson Reuters) Pathways for TOP1
        Cell cycle Chromosome condensation in prometaphase
    Cell cycle Transition and termination of DNA replication

    2 BioSystems Pathways for TOP1
        Integrated Pancreatic Cancer Pathway
    Caspase cascade in apoptosis

    1 PharmGKB Pathway for TOP1
        Irinotecan Pathway, Pharmacodynamics


    TOP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TOP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/542 Interacting proteins for TOP1 (P113871, 2, 3 ENSP000003545224) via UniProtKB, MINT, STRING, and/or I2D (see all 542)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IBA--
    GO:0006265DNA topological change IDA14594810
    GO:0006338chromatin remodeling IBA--
    GO:0007059chromosome segregation IBA--
    GO:0012501programmed cell death NAS17172417

    TOP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TOP1 for compounds           About GeneDecksing

    EMD Millipore small molecules for TOP1:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for TOP1

    Compounds for TOP1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CPT 11DNA topoisomerase I inhibitor; antitumor[100286-90-6]
    Doxorubicin hydrochlorideAntitumor antibiotic agent. Inhibits DNA topoisomerase II[25316-40-9]
    EtoposideTopoisomerase II inhibitor[33419-42-0]
    SN 38DNA topoisomerase I inhibitor; antitumor[86639-52-3]
    CamptothecinDNA topoisomerase inhibitor[7689-03-4]

    7 DrugBank Compounds for TOP1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    TopotecanTopotecan Hcl (see all 5)119413-54-6targetinhibitor9885371 11752352 12437383 12855624 8853931 11443926 12520736 9122737 11166732
    IrinotecanCamptothecin-11 (see all 2)100286-90-6targetinhibitor15975002 19852077 15170677 9342501 11752352 15255290 16309825 16454746
    Camptothecin(+)-camptothecin (see all 8)7689-03-4target--18056711 11752352 10592235 18061144
    Sodium stibogluconateAntimony sodium gluconate (see all 6)16037-91-5targetinhibitor15562618 2835038 10592235
    Lucanthone1-((2-(Diethylamino)ethyl)amino)-4-methylthioxanthen-9-one (see all 7)479-50-5targetinhibitor9169823 10487533
    2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM-- --target--10592235
    4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE-- --target--10592235

    10/124 Novoseek inferred chemical compound relationships for TOP1 gene (see all 124)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    camptothecin 98 1214 11479235 (8), 9305865 (7), 7538195 (7), 14729676 (6) (see all 99)
    topotecan 96 364 9717830 (4), 8621255 (3), 15471886 (3), 14587067 (3) (see all 99)
    irinotecan 92.1 270 18823053 (3), 2168285 (3), 15160997 (3), 8162152 (2) (see all 99)
    9-aminocamptothecin 90.7 43 8892462 (2), 9815685 (2), 8634995 (1), 10912951 (1) (see all 24)
    sn 38 88.5 30 15574786 (2), 9771954 (1), 9825730 (1), 11000580 (1) (see all 28)
    lurtotecan 86.4 13 8611374 (1), 9328158 (1), 11870164 (1), 7834631 (1) (see all 11)
    tdp-1 86.2 52 15494395 (6), 15920477 (3), 16793421 (2), 13679147 (2) (see all 23)
    rebeccamycin 85.8 25 11032967 (3), 12901916 (2), 10322124 (2), 11733535 (1) (see all 19)
    saintopin 82.8 29 9203632 (5), 1646001 (3), 7961822 (2), 7890748 (2) (see all 7)
    9-nitrocamptothecin 82.5 27 11585748 (1), 18434109 (1), 11193897 (1), 9328159 (1) (see all 13)

    Search CenterWatch for drugs/clinical trials and news about TOP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TOP1 gene: 
    NM_003286.2  

    Unigene Cluster for TOP1:

    Topoisomerase (DNA) I
    Hs.472737  [show with all ESTs]
    Unigene Representative Sequence: NM_003286
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000361337(uc010ggd.1 uc010gge.1 uc002xjl.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TOP1
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate TOP1 (see all 52):
    hsa-miR-549 hsa-miR-4307 hsa-miR-3607-3p hsa-miR-1197 hsa-miR-139-5p hsa-miR-25 hsa-miR-485-3p hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidTOP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TOP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOP1
    Clone
    Products:
         
    OriGene clones in human, mouse for TOP1 (see all 5)
    OriGene ORF clones in mouse, rat for TOP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TOP1 (NM_003286)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOP1
    Sirion Biotech Customized lentivirus for stable overexpression of TOP1 
                         Customized lentivirus expression plasmids for stable overexpression of TOP1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TOP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TOP1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOP1

    Additional mRNA sequence: 

    AK225095.1 AK292943.1 AK310508.1 AK310516.1 BC000943.2 BC004475.2 BC039009.1 BC056681.1 
    BC067349.1 BC136297.1 J03250.1 M27913.1 U07804.1 U07806.1 X16479.2 

    14 DOTS entries:

    DT.97780620  DT.425139  DT.99987653  DT.75183810  DT.99955016  DT.120819606  DT.40209313  DT.95191468 
    DT.120819634  DT.40261268  DT.86840413  DT.95194887  DT.95191472  DT.95210182 

    24/299 AceView cDNA sequences (see all 299):

    BX391491 F07589 BX393368 AA371544 CA438301 BX403047 BC056681 CR604483 
    CA488073 AI859596 BU737645 BU625720 AI493041 BP871306 BM541278 AV708869 
    BF109124 R00391 BU632004 BC004475 R76489 BU686012 CB852622 BM974259 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TOP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTCCCTTT
    TOP1 Expression
    About this image


    See TOP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TOP1

    SOURCE GeneReport for Unigene cluster: Hs.472737

    UniProtKB/Swiss-Prot: TOP1_HUMAN, P11387
    Tissue specificity: Endothelial cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including TOP1: 
              Multiple Sclerosis in human mouse rat
              Cancer Drug Resistance in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TOP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TOP1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOP1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TOP1 gene from 10/28 species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Top11 , 5 topoisomerase (DNA) I1, 5 90.85(n)1
    97.25(a)1
      2 (80.96 cM)5
    219691  NM_009408.21  NP_033434.21 
     1606458885 
    chicken
    (Gallus gallus)
    Aves TOP11 topoisomerase (DNA) I 83.73(n)
    92.91(a)
      396004  NM_205110.1  NP_990441.1 
    lizard
    (Anolis carolinensis)
    Reptilia TOP16
    topoisomerase (DNA) I
    90(a)
    1 ↔ 1
    GL343291.1(732962-828849)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.622 Xenopus laevis DNA topoisomerase I (TOP1) mRNA, complete more 78.4(n)    L07777.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570641002   -- 75.23(n)    57064100 
    fruit fly
    (Drosophila melanogaster)
    Insecta Top11 , 3 embryonic morphogenesis DNA
    topoisomerase I3
    Topoisomerase 11
    67(a)3
    61.72(n)1
    63.27(a)1
      1 13B63
    324581  NM_001014742.11  NP_001014742.11 
    worm
    (Caenorhabditis elegans)
    Secernentea top-11 Protein TOP-1 59.05(n)
    58.77(a)
      266847  NM_060936.4  NP_493337.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TOP11 Top1p 52.39(n)
    45.73(a)
      854156   NP_014637.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TOP1BETA1 DNA topoisomerase 1 beta 51.8(n)
    43.41(a)
      835624  NM_124913.3  NP_200342.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g01546001 hypothetical protein 50.87(n)
    44.06(a)
      4344685  NM_001067550.1  NP_001061015.1 


    ENSEMBL Gene Tree for TOP1 (if available)
    TreeFam Gene Tree for TOP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TOP1 gene
    TOP1MT2  
    1 SIMAP similar gene for TOP1 using alignment to 4 protein entries:     TOP1_HUMAN (see all proteins):
    TOP1MT

    TOP1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TOP1
    PGOHUM00000245083


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1678 SNPs in TOP1 are shown (see all 1678)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0075314
    CPT-resistant lung cancer4--see VAR_0075312 T A mis40--------
    VAR_0106674
    CPT-resistant leukemia4--see VAR_0106672 N S mis40--------
    VAR_0106664
    CPT-resistant leukemia4--see VAR_0106662 M T mis40--------
    VAR_0075304
    CPT-resistant leukemia4--see VAR_0075302 D G mis40--------
    VAR_0365554
    Breast cancer4--see VAR_0365552 K R mis40--------
    rs1820487021,2
    C--39623374(+) GGCCAA/GGCTGT 1 -- us2k10--------
    rs1472233141,2
    C--39623454(+) CCACCA/GCGCCT 1 -- us2k10--------
    rs1857151511,2
    --39623460(+) CGCCTG/TGCCTA 1 -- us2k10--------
    rs1901281211,2
    --39623461(+) GCCTGA/GCCTAT 1 -- us2k10--------
    rs1825271121,2
    C--39623508(+) TAGTGC/TGCCGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TOP1 (39657458 - 39753127 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TOP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833982CNV Loss17160897
    nsv833983CNV Loss17160897


    Human Gene Mutation Database (HGMD): TOP1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TOP1
    DNA2.0 Custom Variant and Variant Library Synthesis for TOP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 126420    OMIM disorders: --

    UniProtKB/Swiss-Prot: TOP1_HUMAN, P11387
  • Note=A chromosomal aberration involving TOP1 is found in a form of therapy-related myelodysplastic
    syndrome. Translocation t(11;20)(p15;q11) with NUP98

  • 20/111 diseases for TOP1 (see all 111):    About MalaCards
    scleroderma    molluscum contagiosum    pericardial effusion    ganglioneuroblastoma
    esophageal cancer    uterine carcinosarcoma    hereditary ataxia    collecting duct carcinoma
    xeroderma pigmentosum, group a    chronic myelomonocytic leukemia    leukopenia    xeroderma pigmentosum
    werner syndrome    systemic scleroderma    balanitis    silicosis
    rheumatic disease    central nervous system lymphoma    chronic graft versus host disease    colon cancer

    11 diseases from the University of Copenhagen DISEASES database for TOP1:
    Neutropenia     Systemic scleroderma     Colorectal cancer     Lung cancer
    Diarrhea     Ovarian cancer     Thrombocytopenia     Leukemia
    Vaccinia     Axonal neuropathy     Carcinoma

    TOP1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/93 Novoseek inferred disease relationships for TOP1 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    scan1 81.7 13 15920477 (2), 17600775 (1), 17707402 (1), 16935573 (1)
    solid tumor 67.7 36 16807458 (2), 8835290 (1), 9058732 (1), 10021292 (1) (see all 32)
    neutropenia 67.3 5 8611374 (1), 11081458 (1), 19604089 (1), 15470958 (1) (see all 5)
    sclerosis systemic 66.6 45 7615831 (2), 11465716 (2), 19211583 (2), 1319697 (2) (see all 37)
    colon carcinoma 66.3 16 11594758 (2), 1310066 (1), 9321666 (1), 18538108 (1) (see all 15)
    cancer 64.2 186 19584232 (3), 15735043 (2), 11020283 (2), 12852757 (2) (see all 99)
    ovarian cancer 61.8 29 16462890 (4), 18405948 (2), 9497914 (2), 10502731 (2) (see all 21)
    small cell lung cancer 61.7 16 17645849 (2), 8853931 (1), 15735665 (1), 19996589 (1) (see all 15)
    leukemia p388 61.6 7 9927631 (1), 11205907 (1), 9892183 (1), 11118036 (1) (see all 5)
    leukemia 60.8 40 17418582 (2), 1997159 (1), 1848545 (1), 8914817 (1) (see all 36)

    Genetic Association Database (GAD): TOP1
    Human Genome Epidemiology (HuGE) Navigator: TOP1 (3 documents)

    Export disorders for TOP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TOP1 gene, integrated from 9 sources (see all 1448):
    (articles sorted by number of sources associating them with TOP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sumoylation of topoisomerase I is involved in its partitioning between nucleoli and nucleoplasm and its clearing from nucleoli in response to camptothecin. (PubMed id 12149243)1, 2, 9 Rallabhandi P....D'Arpa P. (2002)
    2. 8-Oxoguanine rearranges the active site of human topoisomerase I. (PubMed id 12209008)1, 2, 9 Lesher D.T....Redinbo M.R. (2002)
    3. Pharmacodynamic genes do not influence risk of neutro penia in cancer patients treated with moderately high-dose irinotecan. (PubMed id 19604089)1, 4, 9 Hoskins J.M....Innocenti F. (2009)
    4. Mutation at the catalytic site of topoisomerase I in CEM/C2, a human leukemia cell line resistant to camptothecin. (PubMed id 7882333)1, 2, 9 Fujimori A.... Pommier Y. (1995)
    5. The mechanism of topoisomerase I poisoning by a camptothecin analog. (PubMed id 12426403)1, 2, 9 Staker B.L....Stewart L. (2002)
    6. Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites. (PubMed id 1849260)1, 2, 9 Tamura H.... Nishikawa K. (1991)
    7. Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565)1, 4 Teslovich T.M....Kathiresan S. (2010)
    8. Simian virus 40 DNA replication is dependent on an interaction between topoisomerase I and the C-terminal end of T antigen. (PubMed id 18003733)1, 2 Khopde S. and Simmons D.T. (2008)
    9. The role of lysine 532 in the catalytic mechanism of human topoisomerase I. (PubMed id 14594810)1, 2 Interthal H....Champoux J.J. (2004)
    10. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7150 HGNC: 11986 AceView: TOP1 Ensembl:ENSG00000198900 euGenes: HUgn7150
    ECgene: TOP1 H-InvDB: TOP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TOP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TOP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TOP1 gene:
    Search GeneIP for patents involving TOP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore small molecules (inhibitor) for TOP1
     Browse Kits and Assays available from EMD Millipore
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TOP1   OriGene RNAi products in human, mouse, rat for TOP1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for TOP1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TOP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for TOP1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TOP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TOP1   OriGene Custom Protein Services for TOP1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TOP1
     QIAGEN SeqTarget long-range PCR primers for resequencing TOP1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOP1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOP1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOP1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOP1
     GenScript Custom Purified and Recombinant Proteins Services for TOP1 GenScript cDNA clones with any tag delivered in your preferred vector for TOP1
     GenScript Custom Assay Services for TOP1 GenScript Custom Superior Antibodies Services for TOP1
     GenScript Custom overexpressing Cell Line Services for TOP1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TOP1 promoter
     Search Chromatin IP Primers for TOP1
     RT2 qPCR Primer Assay in human, mouse, rat TOP1
     GNC Network for TOP1
     SABiosciences PCR Arrays including human, mouse, rat TOP1
     Tocris compounds for TOP1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for TOP1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TOP1 antibodies
     TOP1 proteins
     TOP1 lysates
     Antibodies for TOP1
     See all of Abcam's Antibodies, Kits and Proteins for TOP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for TOP1




     Proteins for TOP1
     Antibodies for TOP1
     ELISAs for TOP1
     CLIAs for TOP1
     Search LifeMap BioReagents cell lines for TOP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOP1
     SwitchGear 3'UTR luciferase reporter plasmids for TOP1
     SwitchGear Promoter luciferase reporter plasmids for TOP1
     ThermoFisher Antibodies for TOP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOP1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TOP1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TOP1
    Customized:
     lentivirus for stable overexpression of TOP1
     lentivirus expression plasmids for stable overexpression of TOP1
     adenovirus for overexpression of TOP1
     LSBio Antibodies in human, mouse, rat for TOP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TOP1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4