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TOMM70A Gene

protein-coding   GIFtS: 62
GCID: GC03M100082

Translocase Of Outer Mitochondrial Membrane 70 Homolog A...

(Previous names: translocase of outer mitochondrial membrane 70 (yeast) homolog...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Translocase Of Outer Mitochondrial Membrane 70 Homolog A (S.
Cerevisiae)1 2
     Translocase Of Outer Mitochondrial Membrane 70 Homolog A (Yeast)1
Mitochondrial Precursor Proteins Import Receptor2 3     Mitochondrial Import Receptor Subunit TOM702
Translocase Of Outer Membrane 70 KDa Subunit2 3     KIAA07193
Translocase Of Outer Mitochondrial Membrane 70 (Yeast) Homolog A1     TOM703

External Ids:    HGNC: 119851   Entrez Gene: 98682   Ensembl: ENSG000001541747   OMIM: 6060815   UniProtKB: O948263   

Export aliases for TOMM70A gene to outside databases

Previous GC identifers: GC03P096528 GC03M099361 GC03M101363 GC03M101403 GC03M101564 GC03M097450


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TOMM70A Gene:
This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the
outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins. (provided by
RefSeq, Oct 2011)

GeneCards Summary for TOMM70A Gene:
TOMM70A (translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include protein transmembrane transporter activity. An important paralog of this gene is TTC1.

UniProtKB/Swiss-Prot: TOM70_HUMAN, O94826
Function: Receptor that accelerates the import of all mitochondrial precursor proteins (By similarity)

Gene Wiki entry for TOMM70A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TOMM70A gene promoter:
         c-Fos   AP-1   Pbx1a   p53   STAT5A   NF-kappaB   YY1   NF-kappaB2   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTOMM70A promoter sequence
   Search Chromatin IP Primers for TOMM70A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TOMM70A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q12.2   Ensembl cytogenetic band:  3q12.2   HGNC cytogenetic band: 3q12.2

TOMM70A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOMM70A gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M100082:  view genomic region     (about GC identifiers)

Start:
100,082,275 bp from pter      End:
100,120,242 bp from pter
Size:
37,968 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TOM70_HUMAN, O94826 (See protein sequence)
Recommended Name: Mitochondrial import receptor subunit TOM70  
Size: 608 amino acids; 67455 Da
Subunit: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which
consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts
with CAPN8 (By similarity)
Sequence caution: Sequence=BAA34439.2; Type=Erroneous initiation;
Secondary accessions: D3DN48

Explore the universe of human proteins at neXtProt for TOMM70A: NX_O94826

Explore proteomics data for TOMM70A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys168, Lys441
  • Modification sites at PhosphoSitePlus

  • See TOMM70A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055635.3  
    ENSEMBL proteins: 
     ENSP00000284320  
    Reactome Protein details: O94826

    TOMM70A Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTC: Tetratricopeptide (TTC) repeat domain containing

    4 InterPro protein domains:
     IPR001440 TPR_1
     IPR011990 TPR-like_helical
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry O94826

    ProtoNet protein and cluster: O94826

    UniProtKB/Swiss-Prot: TOM70_HUMAN, O94826
    Similarity: Belongs to the Tom70 family
    Similarity: Contains 10 TPR repeats


    Find genes that share domains with TOMM70A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TOM70_HUMAN, O94826
    Function: Receptor that accelerates the import of all mitochondrial precursor proteins (By similarity)

         Genatlas biochemistry entry for TOMM70A:
    translocase of outer mitochondrial membrane 70 (yeast) homolog A,Drosophila HSP70/HSP90 organizing protein
    homolog,involved in the import of preprotein into the mitochondria,thyroid hormone regulated in specific brain
    regions

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12526792
    GO:0008320protein transmembrane transporter activity TAS15644312
         
    Find genes that share ontologies with TOMM70A           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for TOMM70A:
     Decreased Tat-dependent transc  Decreased p24 protein expressi  Synthetic lethal with c-Myc af  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TOMM70A
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    miRNA
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    miRTarBase miRNAs that target TOMM70A:
    hsa-mir-342-3p (MIRT043714), hsa-mir-148b-3p (MIRT019499)

    Block miRNA regulation of human, mouse, rat TOMM70A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TOMM70A (see all 53):
    hsa-miR-411* hsa-miR-21* hsa-miR-607 hsa-miR-3607-3p hsa-miR-379* hsa-miR-188-5p hsa-miR-4272 hsa-miR-1294
    SwitchGear 3'UTR luciferase reporter plasmidTOMM70A 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat TOMM70A

    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM70A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TOM70_HUMAN, O94826: Mitochondrion outer membrane; Single-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol3
    endoplasmic reticulum1
    extracellular1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005742mitochondrial outer membrane translocase complex TAS15644312
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TOMM70A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TOMM70A About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    2Mitochondrial Protein Import
    Mitochondrial Protein Import


    Find genes that share SuperPaths with TOMM70A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for TOMM70A
        Mitochondrial protein import


        Pathway & Disease-focused RT2 Profiler PCR Array including TOMM70A: 
              Mitochondria in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TOMM70A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TOMM70A (O948262, 3 ENSP000002843204) via UniProtKB, MINT, STRING, and/or I2D (see all 120)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=2 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=2 
    ENSG00000215328P081073I2D: score=2 
    ENSG00000224501P081073I2D: score=2 
    ENSG00000231555P081073I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion TAS15644312
    GO:0044267cellular protein metabolic process TAS--
    GO:0071806protein transmembrane transport TAS15644312

    Find genes that share ontologies with TOMM70A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TOMM70A (TOM70)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TOMM70A gene: 
    NM_014820.4  

    Unigene Cluster for TOMM70A:

    Translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
    Hs.227253  [show with all ESTs]
    Unigene Representative Sequence: BC065555
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000284320(uc003dtw.3) ENST00000483945 ENST00000492171
    miRNA
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    Block miRNA regulation of human, mouse, rat TOMM70A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TOMM70A (see all 53):
    hsa-miR-411* hsa-miR-21* hsa-miR-607 hsa-miR-3607-3p hsa-miR-379* hsa-miR-188-5p hsa-miR-4272 hsa-miR-1294
    SwitchGear 3'UTR luciferase reporter plasmidTOMM70A 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat TOMM70A
    Clone
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    GenScript: all cDNA clones in your preferred vector: TOMM70A (NM_014820)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOMM70A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM70A
    Primer
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    OriGene qPCR primer pairs and template standards for TOMM70A
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TOMM70A
      QuantiTect SYBR Green Assays in human, mouse, rat TOMM70A
      QuantiFast Probe-based Assays in human, mouse, rat TOMM70A

    Additional mRNA sequence: 

    AB018262.1 AK074951.1 AK075080.1 AK075102.1 AK302796.1 BC003633.2 BC052994.1 BC065555.1 

    13 DOTS entries:

    DT.318250  DT.100822932  DT.95166676  DT.102833977  DT.120881705  DT.120881717  DT.403771  DT.40217703 
    DT.40249429  DT.87010755  DT.97822527  DT.120881709  DT.95307917 

    Selected AceView cDNA sequences (see all 318):

    BE779136 BX500530 BM449461 T32002 BX482828 BF589581 CB148962 AA134420 
    AW471382 AW470297 CA444214 AI962408 BE672376 AW167186 BG163860 AW009918 
    AW468485 BU735925 AI078346 CR596819 BP356283 AW069428 BF057808 BQ888724 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TOMM70A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATTCACC
    TOMM70A Expression
    About this image


    TOMM70A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Thymus (Hematopoietic System)
             Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    TOMM70A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TOMM70A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.227253
        Pathway & Disease-focused RT2 Profiler PCR Array including TOMM70A: 
              Mitochondria in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for TOMM70A
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    QuantiFast Probe-based Assays in human, mouse, rat TOMM70A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM70A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TOMM70A gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tomm70a1 , 5 translocase of outer mitochondrial membrane 70 homolog more1, 5 88.6(n)1
    92.6(a)1
      16 (34.22 cM)5
    281851  NM_138599.51  NP_613065.21 
     571217145 
    chicken
    (Gallus gallus)
    Aves TOMM70A1 translocase of outer mitochondrial membrane 70 homolog more 82.56(n)
    89.16(a)
      418387  XM_416605.4  XP_416605.2 
    lizard
    (Anolis carolinensis)
    Reptilia TOMM70A6
    translocase of outer mitochondrial membrane 70 hom...
    94(a)
    1 ↔ 1
    3(174188232-174201140)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687802 Translocase of outer mitochondrial membrane 70 homolog more 78.91(n)    BC059994.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj58b042 wufj58b04 75.33(n)   336229  BC059538.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG67563
    Tom701
    carrier3
    Translocase of outer membrane 701
    39(a)3
    50.28(n)1
    42.91(a)1
      346181  NM_135692.11  NP_609536.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TOM70(YNL121C)4
    TOM701
    Component of the TOM (translocase of outer membrane) more4
    TOM701
    44.3(n)1
    27.98(a)1
      14(400537-398684)4
    8556021, 4  NP_014278.31  NP_014278.14 


    ENSEMBL Gene Tree for TOMM70A (if available)
    TreeFam Gene Tree for TOMM70A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TOMM70A gene
    TTC12  TOMM342  SPAG12  UNC45A2  UNC45B2  

    Find genes that share paralogs with TOMM70A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TOMM70A (see all 677)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs729414541,2
    C,F--100081811(+) GGAGGG/AGTGGA 1 -- ds50015Minor allele frequency- A:0.16WA NA EA 362
    rs1141904231,2
    C,F--100081831(+) GAAACT/GCCACC 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs754338551,2
    F--100081837(+) CCACCA/GTTCAT 1 -- ds50011Minor allele frequency- G:0.05WA 118
    rs1476709751,2
    --100081901(+) TCAAAC/GTTATT 1 -- ds50010--------
    rs1124774571,2
    F--100081924(+) GAGATG/TCACTG 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs358195211,2
    C--100081968(+) CTACCT/-TTTTT 1 -- ds50012Minor allele frequency- -:0.25NA CSA 4
    rs3771027991,2
    C--100082054(+) CCTCCA/GCTCCC 1 -- ds50010--------
    rs1501736571,2
    --100082061(+) CTCCCA/GGGTTC 1 -- ds50010--------
    rs1905775471,2
    --100082129(+) CACCCA/GGCTAC 1 -- ds50010--------
    rs1386412511,2
    --100082229(+) CTAAAC/GTGCTG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TOMM70A (100082275 - 100120242 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TOMM70A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2725694CNV Deletion23290073
    esv274093CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TOMM70A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606081    OMIM disorders: --


    Find genes that share disorders with TOMM70A           About GenesLikeMe

    Genetic Association Database (GAD): TOMM70A
    Human Genome Epidemiology (HuGE) Navigator: TOMM70A (2 documents)

    Export disorders for TOMM70A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TOMM70A gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with TOMM70A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a thyroid hormone-regulated gene in specific brain regions. (PubMed id 10582581)1, 3, 9 Alvarez-Dolado M....MuA+oz A. (J. Neurochem. 1999)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    5. Characterization of a human import component of the mitochondrial outer membrane, TOMM70A. (PubMed id 12200962)1, 9 Edmonson A.M....Argyropoulos G. (amp 2002)
    6. The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN-dependent mitochondrial clearance. (PubMed id 24149440)1 Bertolin G....Corti O. (Autophagy 2013)
    7. Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. (PubMed id 23503661)1 Sarraf S.A....Harper J.W. (Nature 2013)
    8. Tom70 is essential for PINK1 import into mitochondria. (PubMed id 23472196)1 Kato H....Kozjak-Pavlovic V. (PLoS ONE 2013)
    9. Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)1 Zanon A....Pichler I. (PLoS ONE 2013)
    10. Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. (PubMed id 23798571)1 Roy S.J....Parent J.L. (Mol. Endocrinol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9868 HGNC: 11985 AceView: TOMM70A Ensembl:ENSG00000154174 euGenes: HUgn9868
    ECgene: TOMM70A H-InvDB: TOMM70A

    (According to HUGE)
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    HUGE: KIAA0719

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TOMM70A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TOMM70A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TOMM70A gene:
    Search GeneIP for patents involving TOMM70A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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