TOMM70A Gene
protein-coding GIFtS: 59
GCID: GC03M100082
|
|
translocase of outer mitochondrial membrane 70 homolog A...(Previous names: translocase of outer mitochondrial membrane 70 (yeast)...)
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Aliases
for TOMM70A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Translocase Of Outer Mitochondrial Membrane 70 Homolog A (S. Cerevisiae)1 2 | | Translocase Of Outer Mitochondrial Membrane 70 (Yeast) Homolog A1 | | KIAA07191 3 | | Translocase Of Outer Mitochondrial Membrane 70 Homolog A (Yeast)1 | | Mitochondrial Precursor Proteins Import Receptor2 3 | | Mitochondrial Import Receptor Subunit TOM702 | | Translocase Of Outer Membrane 70 KDa Subunit2 3 | | TOM703 |
Export aliases for TOMM70A gene to outside databasesPrevious GC identifers: GC03P096528 GC03M099361 GC03M101363 GC03M101403 GC03M101564 GC03M097450 |
Summaries
for TOMM70A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TOMM70A:
This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outermembrane complex. This protein is involved in the import of mitochondrial precursor proteins. (provided by RefSeq, Oct2011)
UniProtKB/Swiss-Prot: TOM70_HUMAN, O94826Function: Receptor that accelerates the import of all mitochondrial precursor proteins (By similarity)
Gene Wiki entry for TOMM70A
|
Genomic Views
for TOMM70A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TOMM70A gene promoter:
c-Fos AP-1 Pbx1a p53 STAT5A NF-kappaB YY1 NF-kappaB2 c-Jun NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TOMM70A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOMM70A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q12.2 Ensembl cytogenetic band: 3q12.2 HGNC cytogenetic band: 3q12.2TOMM70A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M100082: view genomic region
(about GC identifiers)
Start:
|
100,082,275 bp from pter |
End:
|
100,120,242 bp from pter |
Size:
|
37,968 bases |
Orientation:
|
minus strand |
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Proteins
for TOMM70A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TOM70_HUMAN, O94826 (See
protein sequence)Recommended Name: Mitochondrial import receptor subunit TOM70 Size: 608 amino acids; 67455 Da
Subunit: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) whichconsists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts withCAPN8 (By similarity)
Subcellular location: Mitochondrion outer membrane; Single-pass membrane protein (By similarity)
Sequence caution: Sequence=BAA34439.2; Type=Erroneous initiation;
Secondary accessions: D3DN48Explore the universe of human proteins at neXtProt for TOMM70A: NX_O94826
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O94826
TOMM70A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055635.3
ENSEMBL proteins: ENSP00000284320 Reactome Protein details: O94826
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TOMM70A for ontologies About GeneDecksing
TOMM70A Antibody Products:
Assay Products for TOMM70A: |
Protein
Domains /
Families
for TOMM70A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TOMM70A for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O94826ProtoNet protein and cluster: O94826 UniProtKB/Swiss-Prot: TOM70_HUMAN, O94826Similarity: Belongs to the Tom70 familySimilarity: Contains 10 TPR repeats |
Function
for TOMM70A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TOM70_HUMAN, O94826Function: Receptor that accelerates the import of all mitochondrial precursor proteins (By similarity) Genatlas biochemistry entry for TOMM70A:translocase of outer mitochondrial membrane 70 (yeast) homolog A,Drosophila HSP70/HSP90 organizing proteinhomolog,involved in the import of preprotein into the mitochondria,thyroid hormone regulated in specific brain regions
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM70A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM70A |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
TOMM70A for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for TOMM70A:
|
Pathways & Interactions
for TOMM70A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Mitochondrial Protein Import | | | 2 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for TOMM70A
TOMM70A for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TOMM70A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/75 Interacting proteins for TOMM70A (O948262, 3 ENSP000002843204) via UniProtKB, MINT, STRING, and/or I2D (see all 75)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006626 | protein targeting to mitochondrion |
TAS | 15644312 | | GO:0044267 | cellular protein metabolic process |
TAS | -- |
TOMM70A for ontologies About GeneDecksing
|
Drugs & Compounds
for TOMM70A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TOMM70A
Search CenterWatch for drugs/clinical trials and news about TOMM70A / TOM70
|
Transcripts
for TOMM70A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TOMM70A gene: NM_014820.4 Unigene Cluster for TOMM70A: Translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae) Hs.227253 [show with all ESTs]Unigene Representative Sequence: BC0655553 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000284320(uc003dtw.3) ENST00000483945 ENST00000492171
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM70A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM70A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TOMM70A (NM_014820) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TOMM70A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM70A |
Additional cDNA sequence: AB018262.1 AK074951.1 AK075080.1 AK075102.1 AK302796.1 BC003633.2 BC052994.1 BC065555.1 13 DOTS entries: DT.318250 DT.100822932 DT.95166676 DT.102833977 DT.120881705 DT.120881717 DT.403771 DT.120881709 DT.40217703 DT.40249429 DT.87010755 DT.97822527 DT.95307917 24/318 AceView cDNA sequences (see all 318): AI669017 CA396591 AI962408 BM311701 BM449461 BQ888724 BE502137 BE622070 BG032640 BU164797 AW069428 AB018262 BU735925 CD519608 AW102995 AI478170 NM_014820 BP356283 AA320578 BU616604 BF589581 AI078346 BU172321 CA444214
GeneLoc Exon Structure
|
Expression
for TOMM70A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TOMM70A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAATTCACC
About this image
See TOMM70A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TOMM70A
SOURCE GeneReport for Unigene cluster: Hs.227253
SABiosciences Expression via Pathway-Focused PCR Array including TOMM70A:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOMM70A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TOMM70A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOMM70A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOMM70A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM70A |
Orthologs
for TOMM70A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for TOMM70A gene from 6/29 species (see all 29) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TOMM70A1 |
translocase of outer mitochondrial membrane 70 homolog more |
82.9(n)
90.19(a) |
|
418387 XM_416605.3 XP_416605.1 |
lizard
(Anolis carolinensis) |
Reptilia |
TOMM70A6 |
-- |
94(a) |
1 ↔ 1 |
3(174188232-174201122) |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC687802 |
Translocase of outer mitochondrial membrane 70 homolog more |
78.91(n) |
|
BC059994.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufj58b042 |
wufj58b04 |
75.33(n) |
|
336229 BC059538.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG67563
Tom701 |
carrier3
Translocase of outer membrane 701 |
39(a)3
49.41(n)1
40.96(a)1 |
|
346181 NM_135692.11 NP_609536.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
TOM70(YNL121C)4
TOM701 |
Component of the TOM (translocase of outer membrane) more4
Tom70p1 |
44.26(n)1
27.87(a)1 |
|
14(400537-398684)4
8556021, 4 NP_014278.31 NP_014278.14 |
ENSEMBL Gene Tree for TOMM70A (if available)
TreeFam Gene Tree for TOMM70A (if available) |
Paralogs
for TOMM70A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TOMM70A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TOMM70A (100082275 - 100120242 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TOMM70A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOMM70A |
|
Disorders
/ Diseases
for TOMM70A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TOMM70A for disorders About GeneDecksing
OMIM gene information: 606081
OMIM disorders: --
5  diseases for TOMM70A: About MalaCardshepatitis c infertility hepatitis thyroiditis
malaria
Human Genome Epidemiology (HuGE) Navigator: TOMM70A (2 documents)
Export disorders for TOMM70A gene to outside databases
|
Publications
for TOMM70A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TOMM70A gene, integrated from 9 sources (see all 40):
(articles sorted by number of sources associating them with TOMM70A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a thyroid hormone-regulated gene in specific brain regions. (PubMed id 10582581)1, 3, 9 Alvarez-Dolado M....Munoz A. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (1998)
- Characterization of a human import component of the mitochondrial outer membrane, TOMM70A. (PubMed id 12200962)1, 9 Edmonson A.M....Argyropoulos G. (2002)
- Mitochondrial hexokinase HKI is a novel substrate of t he Parkin ubiquitin ligase. (PubMed id 23068103)1 Okatsu K....Matsuda N. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Translocase of outer mitochondrial membrane 70 induces interferon response and is impaired by hepatitis C virus NS3. (PubMed id 22032846)1 Kasama Y....Tsukiyama-Kohara K. (2012)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin. (PubMed id 22280891)1 Lazarou M....Youle R.J. (2012)
|
External Searches for TOMM70A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TOMM70A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TOMM70A gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TOMM70A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TOMM70A gene:
Search GeneIP for patents involving TOMM70A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TOMM70A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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 |
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| |
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| | | | Search Tocris compounds for TOMM70A |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | TOMM70A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM70A |
|  |  |  | | | | ThermoFisher Antibodies for TOMM70A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM70A |
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