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Aliases for TOMM70A Gene

Aliases for TOMM70A Gene

  • Translocase Of Outer Mitochondrial Membrane 70 Homolog A (S. Cerevisiae) 2 3
  • Translocase Of Outer Mitochondrial Membrane 70 (Yeast) Homolog A 2
  • Translocase Of Outer Mitochondrial Membrane 70 Homolog A (Yeast) 2
  • Mitochondrial Precursor Proteins Import Receptor 4
  • Translocase Of Outer Membrane 70 KDa Subunit 4
  • KIAA0719 4
  • TOM70 4

External Ids for TOMM70A Gene

Previous GeneCards Identifiers for TOMM70A Gene

  • GC03P096528
  • GC03M099361
  • GC03M101363
  • GC03M101403
  • GC03M101564
  • GC03M100082
  • GC03M097450

Summaries for TOMM70A Gene

Entrez Gene Summary for TOMM70A Gene

  • This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins. [provided by RefSeq, Oct 2011]

GeneCards Summary for TOMM70A Gene

TOMM70A (Translocase Of Outer Mitochondrial Membrane 70 Homolog A (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Mitochondrial Protein Import. GO annotations related to this gene include protein transmembrane transporter activity. An important paralog of this gene is SPAG1.

UniProtKB/Swiss-Prot for TOMM70A Gene

  • Receptor that accelerates the import of all mitochondrial precursor proteins.

Gene Wiki entry for TOMM70A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOMM70A Gene

Genomics for TOMM70A Gene

Regulatory Elements for TOMM70A Gene

Genomic Location for TOMM70A Gene

Start:
100,363,431 bp from pter
End:
100,401,398 bp from pter
Size:
37,968 bases
Orientation:
Minus strand

Genomic View for TOMM70A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TOMM70A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOMM70A Gene

Proteins for TOMM70A Gene

  • Protein details for TOMM70A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94826-TOM70_HUMAN
    Recommended name:
    Mitochondrial import receptor subunit TOM70
    Protein Accession:
    O94826
    Secondary Accessions:
    • D3DN48

    Protein attributes for TOMM70A Gene

    Size:
    608 amino acids
    Molecular mass:
    67455 Da
    Quaternary structure:
    • Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with CAPN8 (By similarity).
    SequenceCaution:
    • Sequence=BAA34439.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TOMM70A Gene

Proteomics data for TOMM70A Gene at MOPED

Post-translational modifications for TOMM70A Gene

  • Ubiquitination at Lys168 and Lys441
  • Modification sites at PhosphoSitePlus

Other Protein References for TOMM70A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TOMM70A Gene

Domains for TOMM70A Gene

Gene Families for TOMM70A Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for TOMM70A Gene

Suggested Antigen Peptide Sequences for TOMM70A Gene

Graphical View of Domain Structure for InterPro Entry

O94826

UniProtKB/Swiss-Prot:

TOM70_HUMAN :
  • O94826
Family:
  • Belongs to the Tom70 family.
Similarity:
  • Contains 10 TPR repeats.
genes like me logo Genes that share domains with TOMM70A: view

Function for TOMM70A Gene

Molecular function for TOMM70A Gene

GENATLAS Biochemistry: translocase of outer mitochondrial membrane 70 (yeast) homolog A,Drosophila HSP70/HSP90 organizing protein homolog,involved in the import of preprotein into the mitochondria,thyroid hormone regulated in specific brain regions
UniProtKB/Swiss-Prot Function: Receptor that accelerates the import of all mitochondrial precursor proteins.

Gene Ontology (GO) - Molecular Function for TOMM70A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12526792
GO:0008320 protein transmembrane transporter activity TAS 15644312
genes like me logo Genes that share ontologies with TOMM70A: view
genes like me logo Genes that share phenotypes with TOMM70A: view

Animal Model Products

CRISPR Products

miRNA for TOMM70A Gene

miRTarBase miRNAs that target TOMM70A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TOMM70A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TOMM70A Gene

Localization for TOMM70A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOMM70A Gene

Mitochondrion outer membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TOMM70A Gene COMPARTMENTS Subcellular localization image for TOMM70A gene
Compartment Confidence
mitochondrion 5
cytosol 3
endoplasmic reticulum 1
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TOMM70A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005742 mitochondrial outer membrane translocase complex TAS 15644312
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with TOMM70A: view

Pathways for TOMM70A Gene

genes like me logo Genes that share pathways with TOMM70A: view

Pathways by source for TOMM70A Gene

2 Reactome pathways for TOMM70A Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TOMM70A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS 15644312
GO:0044267 cellular protein metabolic process TAS --
GO:0071806 protein transmembrane transport TAS 15644312
genes like me logo Genes that share ontologies with TOMM70A: view

Transcripts for TOMM70A Gene

mRNA/cDNA for TOMM70A Gene

Unigene Clusters for TOMM70A Gene

Translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TOMM70A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOMM70A Gene

No ASD Table

Relevant External Links for TOMM70A Gene

GeneLoc Exon Structure for
TOMM70A
ECgene alternative splicing isoforms for
TOMM70A

Expression for TOMM70A Gene

mRNA expression in normal human tissues for TOMM70A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TOMM70A Gene

SOURCE GeneReport for Unigene cluster for TOMM70A Gene Hs.227253

genes like me logo Genes that share expressions with TOMM70A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TOMM70A Gene

Orthologs for TOMM70A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TOMM70A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOMM70A 35
  • 99.73 (n)
  • 99.84 (a)
TOMM70A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TOMM70A 35
  • 93.75 (n)
  • 96.05 (a)
TOMM70A 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TOMM70A 35
  • 93.48 (n)
  • 96.71 (a)
TOMM70A 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tomm70a 35
  • 88.6 (n)
  • 92.6 (a)
Tomm70a 16
Tomm70a 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TOMM70A 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TOMM70A 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tomm70a 35
  • 88.96 (n)
  • 92.59 (a)
chicken
(Gallus gallus)
Aves TOMM70A 35
  • 82.56 (n)
  • 89.16 (a)
TOMM70A 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TOMM70A 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68780 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2314 35
tomm70a 35
  • 76.47 (n)
  • 85.38 (a)
zebrafish
(Danio rerio)
Actinopterygii tomm70a 35
  • 73.3 (n)
  • 83.56 (a)
tomm70a 36
  • 83 (a)
OneToOne
wufj58b04 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009497 35
  • 49.91 (n)
  • 46.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tom70 35
  • 50.28 (n)
  • 42.91 (a)
Tom70 36
  • 39 (a)
OneToOne
CG6756 37
  • 39 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR131W 35
  • 41.7 (n)
  • 26.98 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOM70 35
  • 44.3 (n)
  • 27.98 (a)
TOM70 36
  • 16 (a)
ManyToMany
TOM70 38
TOM71 36
  • 15 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F24046g 35
  • 45.99 (n)
  • 31.6 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04245 35
  • 44.29 (n)
  • 33.86 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tom70 35
  • 47.2 (n)
  • 31.03 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4827 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1056 36
  • 49 (a)
OneToOne
Species with no ortholog for TOMM70A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TOMM70A Gene

ENSEMBL:
Gene Tree for TOMM70A (if available)
TreeFam:
Gene Tree for TOMM70A (if available)

Paralogs for TOMM70A Gene

Paralogs for TOMM70A Gene

genes like me logo Genes that share paralogs with TOMM70A: view

Variants for TOMM70A Gene

Sequence variations from dbSNP and Humsavar for TOMM70A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs12591 -- 100,364,013(-) TGTTG(C/G)GAGTA utr-variant-3-prime
rs15266 -- 100,363,568(-) CTATT(C/G)CCTGT utr-variant-3-prime
rs16337 -- 100,364,588(-) TGGGC(-/TAT)AATAT utr-variant-3-prime
rs183932 -- 100,371,520(-) ggagg(C/T)tgagg intron-variant
rs277631 -- 100,379,308(-) TTTCT(C/T)TATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TOMM70A Gene

Variant ID Type Subtype PubMed ID
esv2725694 CNV Deletion 23290073
esv274093 CNV Insertion 20981092

Relevant External Links for TOMM70A Gene

HapMap Linkage Disequilibrium report
TOMM70A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOMM70A Gene

Disorders for TOMM70A Gene

Relevant External Links for TOMM70A

Genetic Association Database (GAD)
TOMM70A
Human Genome Epidemiology (HuGE) Navigator
TOMM70A
genes like me logo Genes that share disorders with TOMM70A: view

No data available for UniProtKB/Swiss-Prot for TOMM70A Gene

Publications for TOMM70A Gene

  1. Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a thyroid hormone-regulated gene in specific brain regions. (PMID: 10582581) Alvarez-Dolado M. … MuA+oz A. (J. Neurochem. 1999) 2 3 23
  2. Characterization of a human import component of the mitochondrial outer membrane, TOMM70A. (PMID: 12200962) Edmonson A.M. … Argyropoulos G. (Cell Commun. Adhes. 2002) 3 23
  3. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for TOMM70A Gene

Sources for TOMM70A Gene

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