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Aliases for TOMM70 Gene

Aliases for TOMM70 Gene

  • Translocase Of Outer Mitochondrial Membrane 70 2 3
  • TOMM70A 3 4 5
  • Translocase Of Outer Mitochondrial Membrane 70 Homolog A (S. Cerevisiae) 2 5
  • Mitochondrial Precursor Proteins Import Receptor 3 4
  • Translocase Of Outer Membrane 70 KDa Subunit 3 4
  • Tom70 3 4
  • Translocase Of Outer Mitochondrial Membrane 70 (Yeast) Homolog A 2
  • Translocase Of Outer Mitochondrial Membrane 70 Homolog A (Yeast) 2
  • Translocase Of Outer Mitochondrial Membrane 70 Homolog A 3
  • KIAA0719 4

External Ids for TOMM70 Gene

Previous HGNC Symbols for TOMM70 Gene

  • TOMM70A

Summaries for TOMM70 Gene

Entrez Gene Summary for TOMM70 Gene

  • This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins. [provided by RefSeq, Oct 2011]

GeneCards Summary for TOMM70 Gene

TOMM70 (Translocase Of Outer Mitochondrial Membrane 70) is a Protein Coding gene. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Transport to the Golgi and subsequent modification. An important paralog of this gene is TTC1.

UniProtKB/Swiss-Prot for TOMM70 Gene

  • Receptor that accelerates the import of all mitochondrial precursor proteins.

Gene Wiki entry for TOMM70 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOMM70 Gene

Genomics for TOMM70 Gene

Regulatory Elements for TOMM70 Gene

Enhancers for TOMM70 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TOMM70 on UCSC Golden Path with GeneCards custom track

Genomic Location for TOMM70 Gene

Chromosome:
3
Start:
100,363,431 bp from pter
End:
100,401,398 bp from pter
Size:
37,968 bases
Orientation:
Minus strand

Genomic View for TOMM70 Gene

Genes around TOMM70 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOMM70 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOMM70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOMM70 Gene

Proteins for TOMM70 Gene

  • Protein details for TOMM70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94826-TOM70_HUMAN
    Recommended name:
    Mitochondrial import receptor subunit TOM70
    Protein Accession:
    O94826
    Secondary Accessions:
    • D3DN48

    Protein attributes for TOMM70 Gene

    Size:
    608 amino acids
    Molecular mass:
    67455 Da
    Quaternary structure:
    • Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with CAPN8 (By similarity).
    SequenceCaution:
    • Sequence=BAA34439.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TOMM70 Gene

Proteomics data for TOMM70 Gene at MOPED

Post-translational modifications for TOMM70 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TOMM70 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TOMM70 Gene

Domains & Families for TOMM70 Gene

Protein Domains for TOMM70 Gene

Suggested Antigen Peptide Sequences for TOMM70 Gene

Graphical View of Domain Structure for InterPro Entry

O94826

UniProtKB/Swiss-Prot:

TOM70_HUMAN :
  • Belongs to the Tom70 family.
  • Contains 10 TPR repeats.
Family:
  • Belongs to the Tom70 family.
Similarity:
  • Contains 10 TPR repeats.
genes like me logo Genes that share domains with TOMM70: view

Function for TOMM70 Gene

Molecular function for TOMM70 Gene

UniProtKB/Swiss-Prot Function:
Receptor that accelerates the import of all mitochondrial precursor proteins.

Gene Ontology (GO) - Molecular Function for TOMM70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008320 protein transmembrane transporter activity TAS 15644312
genes like me logo Genes that share ontologies with TOMM70: view
genes like me logo Genes that share phenotypes with TOMM70: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TOMM70 Gene

Localization for TOMM70 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOMM70 Gene

Mitochondrion outer membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TOMM70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TOMM70: view

No data available for Subcellular locations from COMPARTMENTS for TOMM70 Gene

Pathways & Interactions for TOMM70 Gene

genes like me logo Genes that share pathways with TOMM70: view

Pathways by source for TOMM70 Gene

Gene Ontology (GO) - Biological Process for TOMM70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with TOMM70: view

No data available for SIGNOR curated interactions for TOMM70 Gene

Drugs & Compounds for TOMM70 Gene

No Compound Related Data Available

Transcripts for TOMM70 Gene

mRNA/cDNA for TOMM70 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TOMM70 Gene

No ASD Table

Relevant External Links for TOMM70 Gene

GeneLoc Exon Structure for
TOMM70
ECgene alternative splicing isoforms for
TOMM70

Expression for TOMM70 Gene

No Expression Related Data Available

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TOMM70 Gene

Orthologs for TOMM70 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TOMM70 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TOMM70A 35
  • 93.75 (n)
  • 96.05 (a)
TOMM70A 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TOMM70A 35
  • 93.48 (n)
  • 96.71 (a)
TOMM70A 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tomm70a 35
  • 88.6 (n)
  • 92.6 (a)
Tomm70a 16
Tomm70a 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TOMM70A 35
  • 99.73 (n)
  • 99.84 (a)
TOMM70A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tomm70a 35
  • 88.96 (n)
  • 92.59 (a)
oppossum
(Monodelphis domestica)
Mammalia TOMM70A 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TOMM70A 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves TOMM70A 35
  • 82.56 (n)
  • 89.16 (a)
TOMM70A 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TOMM70A 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2314 35
tomm70a 35
  • 76.47 (n)
  • 85.38 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68780 35
zebrafish
(Danio rerio)
Actinopterygii tomm70a 35
  • 73.3 (n)
  • 83.56 (a)
wufj58b04 35
tomm70a 36
  • 83 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009497 35
  • 49.91 (n)
  • 46.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tom70 35
  • 50.28 (n)
  • 42.91 (a)
Tom70 36
  • 39 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR131W 35
  • 41.7 (n)
  • 26.98 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F24046g 35
  • 45.99 (n)
  • 31.6 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOM70 35
  • 44.3 (n)
  • 27.98 (a)
TOM70 36
  • 16 (a)
ManyToMany
TOM71 36
  • 15 (a)
ManyToMany
TOM70 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4827 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04245 35
  • 44.29 (n)
  • 33.86 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tom70 35
  • 47.2 (n)
  • 31.03 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1056 36
  • 49 (a)
OneToOne
Species with no ortholog for TOMM70:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TOMM70 Gene

ENSEMBL:
Gene Tree for TOMM70 (if available)
TreeFam:
Gene Tree for TOMM70 (if available)

Paralogs for TOMM70 Gene

Paralogs for TOMM70 Gene

genes like me logo Genes that share paralogs with TOMM70: view

Variants for TOMM70 Gene

Sequence variations from dbSNP and Humsavar for TOMM70 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs12591 -- 100,364,013(-) TGTTG(C/G)GAGTA utr-variant-3-prime
rs15266 -- 100,363,568(-) CTATT(C/G)CCTGT utr-variant-3-prime
rs16337 -- 100,364,588(-) TGGGC(-/TAT)AATAT utr-variant-3-prime
rs367622 -- 100,371,383(-) ggagg(C/T)tgagg intron-variant
rs183932 -- 100,371,520(-) ggagg(C/T)tgagg intron-variant

Variation tolerance for TOMM70 Gene

Residual Variation Intolerance Score: 17.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TOMM70 Gene

HapMap Linkage Disequilibrium report
TOMM70

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TOMM70 Gene

Disorders for TOMM70 Gene

Relevant External Links for TOMM70

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TOMM70

No disorders were found for TOMM70 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TOMM70 Gene

Publications for TOMM70 Gene

  1. Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a thyroid hormone-regulated gene in specific brain regions. (PMID: 10582581) Alvarez-Dolado M. … MuA+oz A. (J. Neurochem. 1999) 2 3 23 67
  2. Characterization of a human import component of the mitochondrial outer membrane, TOMM70A. (PMID: 12200962) Edmonson A.M. … Argyropoulos G. (Cell Commun. Adhes. 2002) 3 23
  3. Parkin maintains mitochondrial levels of the protective Parkinson's disease-related enzyme 17-I^ hydroxysteroid dehydrogenase type 10. (PMID: 25591737) Bertolin G. … Corti O. (Cell Death Differ. 2015) 3
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  5. Tom70 mediates Sendai virus-induced apoptosis on mitochondria. (PMID: 25609812) Wei B. … Wang C. (J. Virol. 2015) 3

Products for TOMM70 Gene

Sources for TOMM70 Gene

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