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TOMM7 Gene

protein-coding   GIFtS: 51
GCID: GC07M022853

Translocase Of Outer Mitochondrial Membrane 7 Homolog (Yeast)

  Search for TOMM7
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Translocase Of Outer Mitochondrial Membrane 7 Homolog (Yeast)1 2
Translocase Of Outer Membrane 7 KDa Subunit Homolog2 3
TOM72 3
6.2 Kd Protein2
Mitochondrial Import Receptor Subunit TOM7 Homolog2
TOMM073

External Ids:    HGNC: 216481   Entrez Gene: 545432   Ensembl: ENSG000001966837   OMIM: 6079805   UniProtKB: Q9P0U13   

Export aliases for TOMM7 gene to outside databases

Previous GC identifers: GC07M022560 GC07M022594 GC07M022626 GC07M022818 GC07M022735


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TOMM7 Gene:
This gene encodes a subunit of the translocase of the outer mitochondrial membrane. The encoded protein regulates
the assembly and stability of the translocase complex. (provided by RefSeq, Oct 2012)

GeneCards Summary for TOMM7 Gene:
TOMM7 (translocase of outer mitochondrial membrane 7 homolog (yeast)) is a protein-coding gene. GO annotations related to this gene include protein transmembrane transporter activity.

UniProtKB/Swiss-Prot: TOM7_HUMAN, Q9P0U1
Function: Required for assembly and stability of the TOM complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the TOMM7 gene promoter:
         ISGF-3   LHX3b/Lhx3b   Pbx1a   POU3F1   Evi-1   E47   HFH-1   LHX3a/Lhx3a   Hand1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTOMM7 promoter sequence
   Search Chromatin IP Primers for TOMM7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TOMM7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.3   Ensembl cytogenetic band:  7p15.3   HGNC cytogenetic band: 7p15.3

TOMM7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOMM7 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M022853:  view genomic region     (about GC identifiers)

Start:
22,852,251 bp from pter      End:
22,862,470 bp from pter
Size:
10,220 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 22,903,376-22,913,545     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TOM7_HUMAN, Q9P0U1 (See protein sequence)
Recommended Name: Mitochondrial import receptor subunit TOM7 homolog  
Size: 55 amino acids; 6248 Da
Subunit: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which
consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70)
Secondary accessions: O95939

Explore the universe of human proteins at neXtProt for TOMM7: NX_Q9P0U1

Explore proteomics data for TOMM7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys17
  • Modification sites at PhosphoSitePlus

  • See TOMM7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061932.1  
    ENSEMBL proteins: 
     ENSP00000351214   ENSP00000385203   ENSP00000361970  
    Reactome Protein details: Q9P0U1

    TOMM7 Human Recombinant Protein Products:

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    Novus Biologicals TOMM7 Lysate
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for TOMM7

    TOMM7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Custom Antibody Services for TOMM7
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    Cloud-Clone Corp. Antibodies for TOMM7
    Search ThermoFisher Antibodies for TOMM7
    Search LSBio for Antibodies for TOMM7

    TOMM7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TOMM7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TOMM7
    Cloud-Clone Corp. CLIAs for TOMM7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR012621 Tom7

    Graphical View of Domain Structure for InterPro Entry Q9P0U1

    ProtoNet protein and cluster: Q9P0U1

    1 Blocks protein domain: IPB012621 TOM7

    UniProtKB/Swiss-Prot: TOM7_HUMAN, Q9P0U1
    Similarity: Belongs to the Tom7 family


    TOMM7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TOM7_HUMAN, Q9P0U1
    Function: Required for assembly and stability of the TOM complex

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12198123
    GO:0008320protein transmembrane transporter activity TAS15644312
         
    TOMM7 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TOMM7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TOMM7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TOMM7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TOMM7

    miRNA
    Products:
        
    miRTarBase miRNAs that target TOMM7:
    hsa-mir-615-3p (MIRT040020)

    Block miRNA regulation of human, mouse, rat TOMM7 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TOMM7
    SwitchGear 3'UTR luciferase reporter plasmidTOMM7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TOMM7
    Predesigned siRNA for gene silencing in human, mouse, rat TOMM7

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for TOMM7

    Clone
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    OriGene clones in human, mouse for TOMM7 (see all 6)
    OriGene ORF clones in mouse, rat for TOMM7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TOMM7 (NM_014820)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOMM7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM7

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TOM7_HUMAN, Q9P0U1: Mitochondrion outer membrane; Single-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA12198123
    GO:0005742mitochondrial outer membrane translocase complex IDA12198123
    GO:0016021integral component of membrane IEA--

    TOMM7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TOMM7 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    2Mitochondrial Protein Import
    Mitochondrial Protein Import

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for TOMM7
        Mitochondrial protein import



    TOMM7 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TOMM7
    Interactions:

        Search GeneGlobe Interaction Network for TOMM7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TOMM7 (Q9P0U11, 3 ENSP000003512144) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TOMM22Q9NS691, 3, ENSP000002160344EBI-1180558,EBI-1047508 I2D: score=2 STRING: ENSP00000216034
    TOMM40O960083, ENSP000002524874I2D: score=2 STRING: ENSP00000252487
    CHCHD4ENSP000002957674STRING: ENSP00000295767
    DNAJC19ENSP000003720054STRING: ENSP00000372005
    GFERENSP000002481144STRING: ENSP00000248114
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion TAS15644312
    GO:0030150protein import into mitochondrial matrix IEA--
    GO:0044267cellular protein metabolic process TAS--

    TOMM7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TOMM7 (TOM7)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TOMM7 gene: 
    NM_019059.3  

    Unigene Cluster for TOMM7:

    Translocase of outer mitochondrial membrane 7 homolog (yeast)
    Hs.112318  [show with all ESTs]
    Unigene Representative Sequence: CD048567
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000463284 ENST00000358435(uc003svk.3) ENST00000483581 ENST00000405021
    ENST00000372879 ENST00000496129
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TOMM7 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TOMM7
    SwitchGear 3'UTR luciferase reporter plasmidTOMM7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TOMM7
    Predesigned siRNA for gene silencing in human, mouse, rat TOMM7
    Clone
    Products:
         
    OriGene clones in human, mouse for TOMM7 (see all 6)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TOMM7 (NM_014820)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOMM7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM7
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TOMM7
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat TOMM7
      QuantiTect SYBR Green Assays in human, mouse, rat TOMM7
      QuantiFast Probe-based Assays in human, mouse, rat TOMM7

    Additional mRNA sequence: 

    AF086336.1 AF150733.1 AJ011007.1 AK026520.1 BC001732.1 BC071973.1 CR456960.1 

    15 DOTS entries:

    DT.100861392  DT.87017313  DT.102829396  DT.100689421  DT.120878158  DT.100806946  DT.100057581  DT.100009074 
    DT.121049623  DT.87001802  DT.92475107  DT.40286998  DT.95288390  DT.100891992  DT.121049619 

    652 AceView cDNA sequences (see top 24):

    N41855 BE391434 AA654904 F27385 CA866806 BU951799 BQ673586 AA385602 
    BC001732 BF025770 AA320314 AA640125 AW772838 F31347 BM849294 BM738805 
    BM840487 BQ935404 AA635536 F31370 BQ683453 BU191705 BG760143 BM764622 
    AA878329 BM761830 BQ642847 F25361 BG761632 BM673042 AI052423 C02394 
    BE731106 CD674314 BQ935480 F34828 BI710991 BU174237 AI022931 CR599481 
    BU528966 BU527334 BU174933 AA088601 AA872028 AA973392 AA516008 AI004087 
    BG219908 F34876 BQ680297 BU164304 F29525 BM760303 BM693017 AA314957 
    BQ214575 BU726515 BQ950878 AA864985 BQ226213 BU526762 F36124 AJ713108 
    BQ670128 BU166579 BQ066463 BE512790 CD251574 BQ056695 F30546 AW440882 
    BM840392 AA983421 AJ571784 BM838735 BG291300 BM046910 F27059 BM504715 
    F28781 BE166932 AA657783 BM010691 AI081267 BQ052333 F37503 BI117167 
    AA491805 BG423051 AA961025 BQ957485 BE122909 BE302745 W73149 AA873399 
    F19555 BQ672353 CD512737 BG756969 F26003 AA876351 AF086336 AA306205 
    BM791643 AA601970 BQ013721 F37570 BE166905 BF939976 AW518526 AI279125 
    BU501847 AW006968 BU542471 AA365883 BE392599 AI470256 F27735 BG766143 
    CD173105 F28746 NM_019059 AL120461 AA157326 BM044474 BG030532 F25748 
    CD176242 F32299 AA733085 F19187 AJ571936 BP373387 BG759782 BU899302 
    BG754182 BF026840 AW079431 AA770267 AW261972 BF975730 F28802 AA723130 
    BM689384 BE294417 BG685085 AJ011007 BQ677632 BI493285 BG756916 AA568254 
    F25330 AK026520 CA943824 AA367301 BF446391 AI268835 BF224263 CA455332 
    AF150733 F27895 AA576245 BG150499 CB156667 BQ549907 F25934 BM045052 
    CB958387 BE207548 CK903276 BF974825 F33279 AA515132 AA644209 CK820524 
    BI256614 BX345336 AA669713 CD516352 AA317851 CN484620 BE394515 AA363902 
    BC071973 BG332645 AW131452 F28367 F35517 BG761411 AW008704 BM558566 
    BG470826 AI311314 BE878782 AW273628 AI824129 F26026 BF974126 AI031923 
    F31130 F35977 F26838 AI817693 BF664386 BG774281 BF129131 F24766 
    AA557367 BE383821 BG340737 F20666 AI692598 BM009928 BI160960 AA508524 
    BE675529 AW161266 AA148508 AA737264 BU589437 AA211509 BM737763 AA157424 
    BM555777 AL706670 F33538 BG769466 AI499169 BU071895 AA864465 F35560 
    BG472261 BG684498 F25155 CB109376 BU502560 AA729891 BE786943 AJ573236 
    BE166926 F21240 F28421 BI756207 AA969469 AA635395 CR456960 BE166861 
    AA320703 BU539929 W33001 F37642 AA581779 AA040209 F31304 BE898486 
    BE076922 F23569 BG944367 AA194521 BF182810 AA186406 BI669114 BQ021437 
    CD175635 F22523 AW877529 BQ694253 F34417 AA894438 AA211557 CA866539 
    BU858772 BQ778264 BF312854 BU588331 F29715 AA632304 AA995548 AW168966 
    BG335819 AW797829 BU567108 AA831379 F30534 BU580518 F27946 CD247270 
    AI086612 F34000 CD175150 AA156616 F30626 AA186477 F34117 AA936775 
    BI490527 F28336 BE727673 F33860 BG501107 CD555983 BE166912 F28338 
    F32436 BG107438 CD388375 BU564274 AA961415 AA569094 BM691167 AI832508 
    F27502 BG684703 AI004544 AA911786 BE166927 BG764726 F25149 W65375 
    AW877522 AA095201 AA652224 BE166928 BE734067 F25201 AA352512 BU580975 
    BM788501 AA559144 F32478 AA344802 AI073649 AJ574576 F25625 AA468925 
    F28324 BM505037 BF211064 AA651971 AA215947 AI300884 F24994 AA559160 
    BU860663 CD175043 F24768 AA658921 CD250007 CB997799 CD385354 CD389440 
    AI479081 CD175515 CD175970 CD249695 CD175708 CD384875 CD389641 CD385131 
    CD174978 CD389241 CD246383 F30623 CD249492 CD385633 CD175775 CD172708 
    F25875 CB998618 AJ708084 CD387868 F29082 CD249035 BE076754 CD386526 
    CF123592 BM047712 CD512130 AW798130 CD385371 CD248894 BM915705 CA395995 
    CD389506 BF351394 AA384124 BM546471 F33873 BQ011368 CD173738 CD250132 
    BG211489 AJ707676 CD389960 CD176162 CD176187 AJ708187 CD173552 CD385209 
    CD387321 BU944961 AA558876 CD177647 AW872496 CD250080 BE877798 CD246229 
    BG108760 CD388715 CD556068 AA503188 BI598723 CD389456 CD386131 BM761820 
    F24614 CD389880 F37088 AA578105 BI766949 CD174250 CD175237 CD388543 
    CD175089 CD386740 CD389602 CD174353 BQ943840 F28309 AW877456 CD386130 
    CD556494 CD174271 AA485318 F37740 CD385278 BQ012614 AA714594 AA570050 
    CD386879 CD385105 CD387548 CD639151 CD177064 CD555931 CD247405 CD249365 
    AJ711274 CD385337 BU860904 CD387468 AA229239 CD173416 AW840534 CD174057 
    BQ010889 CD173996 BP343521 BI598162 F33527 CD175711 AW877523 CB159251 
    CD248200 AA577944 BQ012293 CD250338 CD172955 CD249342 BG716013 CD173697 
    AA805865 CF529798 AW872518 CD389969 CD386050 BU533301 BI668404 AA838831 
    BG251791 CD248279 CD174163 AW877524 AA484649 BG218906 CD174535 BF967262 
    BQ671600 AA661467 F26040 CD385320 BG701405 BG207316 BG753955 F32843 
    F23563 BG214176 CF995297 CD174600 CD175545 AW957295 F37648 BX416682 
    CD174198 F37636 CD629644 CA310793 AW877462 W07256 CD173687 BU953475 
    CD173472 CD172806 CD384986 BE207562 CD249662 BU588055 BE045278 CD173412 
    T25736 N83996 CD175556 CD386518 AW651775 BU601187 AI500606 CD176630 
    BQ672282 BM704944 CD173432 F37828 CD176510 BU899205 BP871277 F28208 
    F33149 AA484704 CD173849 CD175430 AW795374 AW877528 CB958503 F21221 
    BM916052 BE166866 CD249495 BE045269 CD176432 AA374033 CD173928 CD248049 
    F36137 BI553551 BF087991 CD174360 BG182445 AA047718 AW772589 BM853215 
    AA658948 AJ712467 CD387458 AW877458 AA714452 CF123829 BU955697 F23486 
    BU502427 CD172758 CD249986 CD107086 BF245098 CD384840 BI551924 BU961001 
    BX416681 CD173369 T47466 CD175879 AJ710038 AI749017 CD386981 CD172653 
    BG489506 AW103356 AW877537 BG396680 BP373213 AW795225 BI824148 BI767357 
    AW516726 BE076866 BF107507 BG473380 BG676902 CD247605 AA680245 BU597837 
    BG769435 BF973104 CD249942 BG150928 BE166917 BU535806 BU566721 BU930177 
    BG475379 BG770171 BU945026 BU787532 CD174070 BF974227 BG474914 BI756269 
    BF132499 BP374850 BQ334902 BG196460 CD629645 BE166913 F37833 AA862649 
    BQ306191 BG206813 BE774639 BX431338 AW840571 BE378383 CB146447 BQ306204 
    CD387047 CD247663 BG341285 AI557912 BU932760 BG686774 BE769376 CD389667 
    BE774628 F35099 BG339049 BM045128 CD385108 CD387730 CD388112 BE254343 
    BF680825 AV701243 AV701246 BI756926 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TOMM7    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b
    SP1:                          -     -               
    SP2:                          -                     
    SP3:                    -     -     -               
    SP4:                                                


    ECgene alternative splicing isoforms for TOMM7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TOMM7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGATGTGT
    TOMM7 Expression
    About this image


    TOMM7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Ovary (Reproductive System)
             Ovarian Somatic Cells Ovigerous Cord
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Tonsil (Hematopoietic System)
    TOMM7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TOMM7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.112318
        Custom PCR Arrays for TOMM7
    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TOMM7 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tomm71 , 5 translocase of outer mitochondrial membrane 7 homolog more1, 5 90.3(n)1
    94.55(a)1
      5 (10.48 cM)5
    661691  NM_025394.31  NP_079670.11 
     238389445 
    chicken
    (Gallus gallus)
    Aves TOMM71 translocase of outer mitochondrial membrane 7 homolog more 80.61(n)
    87.27(a)
      420610  NM_001199617.1  NP_001186546.1 
    lizard
    (Anolis carolinensis)
    Reptilia TOMM76
    translocase of outer mitochondrial membrane 7 homo...
    84(a)
    1 ↔ 1
    6(30312298-30321818)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.253772 Xenopus laevis transcribed sequence with moderate similarity more 73.74(n)    BJ051727.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tomm76
    translocase of outer mitochondrial membrane 7 homo...
    82(a)
    1 ↔ 1
    19(3109049-3118843) ENSDARG00000067717


    ENSEMBL Gene Tree for TOMM7 (if available)
    TreeFam Gene Tree for TOMM7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TOMM7 gene
    1 SIMAP similar gene for TOMM7 using alignment to 3 protein entries:     TOM7_HUMAN (see all proteins):
    TOM7

    TOMM7 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TOMM7
    PGOHUM00000245628 PGOHUM00000235547


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TOMM7 (see all 311)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs732782661,2
    C,F--22851877(+) CCCAAC/TAGGCT 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs171472901,2
    C,F,H--22851967(+) TAGAAG/AAACGG 1 -- ds50018Minor allele frequency- A:0.15NA NS WA EA 694
    rs1812107961,2
    --22851970(+) AAGAAC/TGGAAA 1 -- ds50010--------
    rs1866662791,2
    --22851989(+) TAATAA/GAAGTA 1 -- ds50010--------
    rs1449771291,2
    --22852049(+) AACTAC/GTTTCC 1 -- ds50010--------
    rs1125994041,2
    C--22852424(+) AAAAAT/ATTTTT 1 -- ut311Minor allele frequency- A:0.50WA 2
    rs778936811,2
    C,F--22852436(+) ATATCG/ATGATC 1 -- ut311Minor allele frequency- A:0.06WA 118
    rs22407281,2
    C,F--22852499(-) TGTGTA/GTACCT 1 -- ut31 ese312Minor allele frequency- G:0.42NA WA CSA EA 376
    rs22407271,2
    C,F,H--22852512(-) AACAGA/GGAATT 1 -- ut31 ese323Minor allele frequency- G:0.45EA NS NA WA CSA 3832
    rs1118246911,2
    C--22852591(+) AGCATA/TACACT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TOMM7 (22852251 - 22862470 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TOMM7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv272529CNV Insertion20981092
    esv269276CNV Insertion20981092
    esv2467344CNV Insertion19546169
    nsv526131CNV Loss19592680
    dgv2070e1CNV Complex17122850
    nsv7393OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TOMM7
    DNA2.0 Custom Variant and Variant Library Synthesis for TOMM7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607980    OMIM disorders: --


    TOMM7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TOMM7
    Human Genome Epidemiology (HuGE) Navigator: TOMM7 (2 documents)

    Export disorders for TOMM7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TOMM7 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with TOMM7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane. (PubMed id 12198123)1, 2, 3 Johnston A.J.... Ryan M.T. (J. Biol. Chem. 2002)
    2. Cloning and characterization of the human novel gene encoding 6.2 kDa protein highly expressed upon ultraviolet irradiation in DNA-PK- deleted human glioma M059J cells. (PubMed id 10647823)1, 2, 3 Lee J.-S. (DNA Seq. 1999)
    3. Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. (PubMed id 18331822)1, 2, 9 Kato H. and Mihara K. (Biochem. Biophys. Res. Commun. 2008)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Multiethnic meta-analysis of genome-wide association studies in &gt;100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. (PubMed id 23969696)1 Sabater-Lleal M....O'Donnell C.J. (Circulation 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54543 HGNC: 21648 AceView: TOMM7 Ensembl:ENSG00000196683 euGenes: HUgn54543
    ECgene: TOMM7 H-InvDB: TOMM7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TOMM7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TOMM7 gene:
    Search GeneIP for patents involving TOMM7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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