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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TOMM7 Gene

protein-coding   GIFtS: 50
GCID: GC07M022818

Translocase Of Outer Mitochondrial Membrane 7 Homolog (Yeast)

  Search for TOMM7
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Translocase Of Outer Mitochondrial Membrane 7 Homolog (Yeast)1 2
Translocase Of Outer Membrane 7 KDa Subunit Homolog2 3
TOM72 3
6.2 Kd Protein2
Mitochondrial Import Receptor Subunit TOM7 Homolog2
TOMM073

External Ids:    HGNC: 216481   Entrez Gene: 545432   Ensembl: ENSG000001966837   OMIM: 6079805   UniProtKB: Q9P0U13   

Export aliases for TOMM7 gene to outside databases

Previous GC identifers: GC07M022560 GC07M022594 GC07M022626 GC07M022735


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TOMM7 Gene:
This gene encodes a subunit of the translocase of the outer mitochondrial membrane. The encoded protein regulates
the assembly and stability of the translocase complex. (provided by RefSeq, Oct 2012)

GeneCards Summary for TOMM7 Gene: 
TOMM7 (translocase of outer mitochondrial membrane 7 homolog (yeast)) is a protein-coding gene. Among its related super-pathways are Post-translational protein modification. GO annotations related to this gene include protein transmembrane transporter activity and P-P-bond-hydrolysis-driven protein transmembrane transporter activity.

UniProtKB/Swiss-Prot: TOM7_HUMAN, Q9P0U1
Function: Required for assembly and stability of the TOM complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TOMM7 gene promoter:
         ISGF-3   LHX3b/Lhx3b   Pbx1a   POU3F1   Evi-1   E47   HFH-1   LHX3a/Lhx3a   Hand1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTOMM7 promoter sequence
   Search SABiosciences Chromatin IP Primers for TOMM7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOMM7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.3   Ensembl cytogenetic band:  7p15.3   HGNC cytogenetic band: 7p15.3

TOMM7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOMM7 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M022818:  view genomic region     (about GC identifiers)

Start:
22,852,251 bp from pter      End:
22,862,470 bp from pter
Size:
10,220 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 22,903,376-22,913,545     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TOM7_HUMAN, Q9P0U1 (See protein sequence)
Recommended Name: Mitochondrial import receptor subunit TOM7 homolog  
Size: 55 amino acids; 6248 Da
Subunit: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which
consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70)
Subcellular location: Mitochondrion outer membrane; Single-pass membrane protein
Secondary accessions: O95939

Explore the universe of human proteins at neXtProt for TOMM7: NX_Q9P0U1

Explore proteomics data for TOMM7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P0U1

  • TOMM7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TOMM7 Protein Expression
    REFSEQ proteins: NP_061932.1  
    ENSEMBL proteins: 
     ENSP00000351214   ENSP00000385203   ENSP00000361970  
    Reactome Protein details: Q9P0U1
    Human Recombinant Protein Products for TOMM7: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for TOMM7
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    Novus Biologicals TOMM7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TOMM7 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA12198123
    GO:0005742mitochondrial outer membrane translocase complex IDA12198123
    GO:0016021integral to membrane IEA--

    TOMM7 for ontologies           About GeneDecksing



    TOMM7 Antibody Products: 
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    Assay Products for TOMM7: 
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    Cloud-Clone Corp. ELISAs for TOMM7 
    Cloud-Clone Corp. CLIAs for TOMM7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR012621 Tom7

    Graphical View of Domain Structure for InterPro Entry Q9P0U1

    ProtoNet protein and cluster: Q9P0U1

    1 Blocks protein domain: IPB012621 TOM7

    UniProtKB/Swiss-Prot: TOM7_HUMAN, Q9P0U1
    Similarity: Belongs to the Tom7 family


    TOMM7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TOM7_HUMAN, Q9P0U1
    Function: Required for assembly and stability of the TOM complex

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12198123
    GO:0008320protein transmembrane transporter activity TAS15644312
         
    TOMM7 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TOMM7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TOMM7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TOMM7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TOMM7 

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TOMM7
    SwitchGear 3'UTR luciferase reporter plasmidTOMM7 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TOMM7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOMM7

    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of TOMM7

    Clone
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    GenScript: all cDNA clones in your preferred vector: TOMM7 (NM_014820)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOMM7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM7
    Sirion Biotech Customized lentivirus for stable overexpression of TOMM7 
                         Customized lentivirus expression plasmids for stable overexpression of TOMM7 

    Cell Line
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    Search LifeMap BioReagents cell lines for TOMM7
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TOMM7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    2Mitochondrial Protein Import
    Mitochondrial Protein Import

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for TOMM7
        Mitochondrial Protein Import
    Metabolism of proteins



    TOMM7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TOMM7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/27 Interacting proteins for TOMM7 (Q9P0U11, 3 ENSP000003512144) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TOMM22Q9NS691, 3, ENSP000002160344EBI-1180558,EBI-1047508 I2D: score=2 STRING: ENSP00000216034
    TOMM40O960083, ENSP000002524874I2D: score=2 STRING: ENSP00000252487
    DNAJC19ENSP000003720054STRING: ENSP00000372005
    GRPEL1ENSP000002649544STRING: ENSP00000264954
    MTX1ENSP000003573604STRING: ENSP00000357360
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion TAS15644312
    GO:0030150protein import into mitochondrial matrix IEA--
    GO:0044267cellular protein metabolic process TAS--

    TOMM7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TOMM7 (TOM7)

    Search CenterWatch for drugs/clinical trials and news about TOMM7 / TOM7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TOMM7 gene: 
    NM_019059.3  

    Unigene Cluster for TOMM7:

    Translocase of outer mitochondrial membrane 7 homolog (yeast)
    Hs.112318  [show with all ESTs]
    Unigene Representative Sequence: CD048567
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000463284 ENST00000358435(uc003svk.3) ENST00000483581 ENST00000405021
    ENST00000372879 ENST00000496129
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TOMM7
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TOMM7
    SwitchGear 3'UTR luciferase reporter plasmidTOMM7 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TOMM7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOMM7
    Clone
    Products:
         
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    OriGene ORF clones in mouse, rat for TOMM7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TOMM7 (NM_014820)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOMM7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM7
    Sirion Biotech Customized lentivirus for stable overexpression of TOMM7 
                         Customized lentivirus expression plasmids for stable overexpression of TOMM7 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TOMM7
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat TOMM7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOMM7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOMM7

    Additional mRNA sequence: 

    AF086336.1 AF150733.1 AJ011007.1 AK026520.1 BC001732.1 BC071973.1 CR456960.1 

    15 DOTS entries:

    DT.100861392  DT.87017313  DT.102829396  DT.100689421  DT.120878158  DT.100806946  DT.100057581  DT.100009074 
    DT.121049623  DT.87001802  DT.92475107  DT.40286998  DT.95288390  DT.100891992  DT.121049619 

    652 AceView cDNA sequences (see top 24):

    BE731106 C02394 N41855 AW772838 AI022931 F25361 AA872028 BM761830 
    BU191705 AA640125 BG219908 AA088601 BM840487 BQ066463 BU166579 BU726515 
    BQ214575 BU174237 BQ935480 BU174933 BQ642847 AA385602 CD674314 BM673042 
    AI004087 AA983421 BQ226213 BQ056695 BG761632 AA320314 F34828 F31370 
    BM764622 AA864985 BU164304 BM738805 BQ950878 BF025770 AA314957 AJ713108 
    AW440882 F31347 AA654904 BE391434 BM693017 BG760143 BQ680297 BE512790 
    BU951799 BM849294 BU528966 AA878329 AA635536 F36124 BU527334 BQ683453 
    BU526762 BM760303 CD251574 F30546 F34876 F29525 BI710991 BM840392 
    AJ571784 BQ935404 AA516008 BQ673586 AA973392 BQ670128 F27385 CR599481 
    CA866806 AI052423 BC001732 AA363902 F32299 BE207548 CK903276 AJ573236 
    AA367301 AI824129 BE294417 BQ957485 BM046910 BE166905 F28421 BG754182 
    AA211509 AW273628 BE878782 BP373387 F37503 F33279 AA729891 BE786943 
    F25155 AA770267 BG766143 AA365883 F26026 AA576245 AA568254 BQ677632 
    BM737763 AA557367 AA306205 AW161266 BM558566 AK026520 AA737264 F35517 
    AW006968 F27735 CK820524 F35977 AA733085 BG774281 AW518526 AI311314 
    BM010691 BE302745 F25330 BM689384 AA864465 BG761411 F35560 F26838 
    W73149 BF129131 BM044474 BG684498 CA943824 CD173105 AL120461 BI493285 
    AW008704 CD516352 BX345336 BG423051 BQ052333 BI256614 BM838735 BG769466 
    BQ549907 BF974825 AJ011007 F33538 AI081267 BE392599 CB156667 BM555777 
    BG332645 BI117167 AI279125 BF975730 BE675529 AA723130 F28802 AW261972 
    BM009928 BU589437 BG685085 CD176242 F24766 AA961025 BG150499 F19187 
    BG030532 BG756969 BE166932 CB958387 BF026840 BG472261 AA157326 BM504715 
    BQ672353 AA157424 BF224263 BE122909 AA491805 AA644209 BQ013721 BF939976 
    AA508524 BF664386 AW131452 F20666 BM791643 AA601970 BF446391 CN484620 
    F28746 F31130 AA515132 F25748 BG470826 BG759782 AW079431 F27059 
    F21240 F37570 CD512737 BE383821 BI160960 AA657783 AA317851 F19555 
    AA148508 F28781 BG756916 BF974126 AI031923 AI499169 BU899302 F28367 
    BM045052 BG340737 BU071895 CB109376 BE166926 AA669713 F26003 AA876351 
    BC071973 F25934 AI692598 AI470256 AF086336 AI817693 AA873399 AF150733 
    CA455332 BU502560 BG291300 F27895 BI756207 AJ571936 BU501847 AI268835 
    NM_019059 BE394515 AL706670 BU542471 AA936775 AA635395 CD247270 BE166861 
    F28324 F29715 W65375 CD388375 F37642 AA352512 F30534 AA581779 
    AA652224 F24994 AA186477 AA995548 AA186406 BG684703 BE898486 AA969469 
    BM691167 AI086612 AA559160 F28336 AA320703 F28338 BU539929 BM788501 
    AA961415 BG501107 AA651971 BI490527 BQ778264 BF211064 AI300884 AA632304 
    AI004544 F27502 BU860663 W33001 BI669114 BQ694253 AW877522 CD175150 
    BU567108 AA831379 AA040209 F25201 BM505037 BG764726 AA095201 CR456960 
    BU588331 AA468925 F32436 BU564274 BF182810 BG944367 BG335819 AI832508 
    F34000 F25625 AJ574576 BE734067 BE166928 AA215947 AA569094 CD175635 
    BQ021437 AW168966 CA866539 AA211557 F22523 F34117 AA911786 F34417 
    CD175043 AA894438 F25149 F33860 BU858772 BE166927 AA344802 F31304 
    AA194521 BF312854 F23569 BG107438 AI073649 F27946 BE076922 AW797829 
    AW877529 AA559144 F30626 CD555983 BE727673 AA156616 F32478 BU580518 
    BE166912 BU580975 AJ707676 CD173996 CD247405 CA395995 CD174057 AA229239 
    CD249492 BM546471 CD389440 F33873 CD512130 CD175515 BQ012614 F37088 
    CD249342 CD174163 CD387868 BU533301 CD389241 CD172955 BG251791 CD389456 
    CD385371 BG716013 CD388715 AW872518 CD385633 CD386526 BQ012293 BP343521 
    F33527 CD176162 AW877456 CD173552 BQ943840 CD386130 AA658921 BE076754 
    CD385354 CB159251 BI598723 CD174250 CD389641 CD250080 AA805865 CD175970 
    CD385337 BQ011368 AW877524 BI598162 CD389880 F24614 AJ708187 BG211489 
    BU944961 CD248894 CD386050 AA384124 CB998618 CF529798 CD174978 CD177064 
    CD389969 CD176187 BM047712 AW798130 CD385131 BF351394 CD385209 CD248279 
    CD250132 CD246229 F30623 BI766949 CD249035 CD385278 F25875 CD386740 
    AA714594 CD556068 CD173697 CD389506 CD386131 CD389602 CD175237 AA558876 
    F29082 CD249365 CD175775 AA570050 BI668404 CB997799 CD174353 AA485318 
    BE877798 CD639151 AJ711274 CD250007 CD389960 BU860904 CD555931 CD386879 
    CD174271 AA578105 F37740 CD387468 CD388543 CD172708 CD384875 CD173738 
    CF123592 CD385105 AW840534 CD175089 CD556494 AW877523 CD387548 CD387321 
    AA503188 AA838831 F28309 F24768 CD246383 BM761820 CD175711 CD177647 
    AW872496 CD249695 BG108760 CD173416 BM915705 AJ708084 AI479081 CD248200 
    CD250338 AA577944 CD175708 BQ010889 F37636 CD176432 CD174198 BX416682 
    CD173928 AW957295 BP871277 BM916052 BG207316 AW877462 BE045278 CD173412 
    F21221 F23563 F32843 CD176630 CD175556 BM704944 BG218906 BU601187 
    F28208 T25736 AW651775 W07256 CD173472 AA661467 CD248049 AA374033 
    BI553551 CD386518 CD385320 BG701405 BE207562 CD249662 CD172806 BG753955 
    N83996 F36137 BQ672282 CD174600 AA484704 F37828 BE045269 BU899205 
    AA484649 CD176510 CD384986 CD249495 CD173849 BU588055 BF967262 F37648 
    AW877528 CA310793 CB958503 BQ671600 CD175430 CD173687 F33149 BE166866 
    CD173432 F26040 AW795374 CF995297 CD175545 CD174535 AI500606 BU953475 
    BG214176 CD629644 BU502427 CD249986 BG182445 AJ712467 CD386981 CD173369 
    CD387458 AW103356 CD384840 BX416681 BF245098 CF123829 BI551924 BU961001 
    BG489506 BU955697 AA714452 AJ710038 CD175879 T47466 AW772589 AI749017 
    AA047718 BM853215 AW877537 CD172758 CD172653 AA658948 F23486 AW877458 
    CD107086 BF087991 CD174360 BF132499 AW795225 BP374850 CD174070 BG676902 
    AW516726 BI756269 CD249942 BU930177 BG475379 BG473380 BE166917 BF974227 
    BI824148 BE076866 BG769435 BI767357 AA680245 CD247605 BG474914 BQ334902 
    BG150928 BP373213 BU787532 BU945026 BG196460 BU597837 BU566721 BU535806 
    BG770171 BG396680 BF107507 BF973104 AW840571 BX431338 BE378383 BE166913 
    CB146447 BQ306191 CD629645 AA862649 BE774639 BQ306204 BG206813 F37833 
    CD387730 AI557912 BI756926 BF680825 F35099 CD247663 BG686774 CD385108 
    CD388112 BE774628 BG339049 BE769376 BM045128 BU932760 AV701246 BE254343 
    CD389667 BG341285 CD387047 AV701243 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TOMM7    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b
    SP1:                          -     -               
    SP2:                          -                     
    SP3:                    -     -     -               
    SP4:                                                


    ECgene alternative splicing isoforms for TOMM7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TOMM7 expression in normal human tissues (normalized intensities)      TOMM7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGATGTGT
    TOMM7 Expression
    About this image


    TOMM7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)
             Ovarian Somatic Cells Ovigerous Cord
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Tonsil (Hematopoietic System)

    See TOMM7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TOMM7

    SOURCE GeneReport for Unigene cluster: Hs.112318
        SABiosciences Custom PCR Arrays for TOMM7
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TOMM7 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tomm71 , 5 translocase of outer mitochondrial membrane 7 homolog more1, 5 90.3(n)1
    94.55(a)1
      5 (10.48 cM)5
    661691  NM_025394.31  NP_079670.11 
     238389445 
    chicken
    (Gallus gallus)
    Aves TOMM71 translocase of outer mitochondrial membrane 7 homolog more 80.61(n)
    87.27(a)
      420610  NM_001199617.1  NP_001186546.1 
    lizard
    (Anolis carolinensis)
    Reptilia TOMM76
    translocase of outer mitochondrial membrane 7 homo...
    80(a)
    1 ↔ 1
    6(30312298-30321818)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.253772 Xenopus laevis transcribed sequence with moderate similarity more 73.74(n)    BJ051727.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tomm71 translocase of outer mitochondrial membrane 7 homolog more 76.97(n)
    83.64(a)
      751649  NM_001161487.1  NP_001154959.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tom76
    Translocase of outer membrane 7
    50(a)
    1 ↔ 1
    2R(4839193-4839685)


    ENSEMBL Gene Tree for TOMM7 (if available)
    TreeFam Gene Tree for TOMM7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TOMM7 gene
    1 SIMAP similar gene for TOMM7 using alignment to 3 protein entries:     TOM7_HUMAN (see all proteins):
    TOM7

    TOMM7 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TOMM7
    PGOHUM00000245628 PGOHUM00000235547


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/311 SNPs in TOMM7 are shown (see all 311)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs732782661,2
    C,F--22851877(+) CCCAAC/TAGGCT 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs171472901,2
    C,F,H--22851967(+) TAGAAG/AAACGG 1 -- ds50018Minor allele frequency- A:0.15NA NS WA EA 694
    rs1812107961,2
    --22851970(+) AAGAAC/TGGAAA 1 -- ds50010--------
    rs1866662791,2
    --22851989(+) TAATAA/GAAGTA 1 -- ds50010--------
    rs1449771291,2
    --22852049(+) AACTAC/GTTTCC 1 -- ds50010--------
    rs1125994041,2
    C--22852424(+) AAAAAT/ATTTTT 1 -- ut311Minor allele frequency- A:0.50WA 2
    rs778936811,2
    C,F--22852436(+) ATATCG/ATGATC 1 -- ut311Minor allele frequency- A:0.06WA 118
    rs22407281,2
    C,F--22852499(-) TGTGTA/GTACCT 1 -- ut31 ese312Minor allele frequency- G:0.42NA WA CSA EA 376
    rs22407271,2
    C,F,H--22852512(-) AACAGA/GGAATT 1 -- ut31 ese323Minor allele frequency- G:0.45EA NS NA WA CSA 3832
    rs1118246911,2
    C--22852591(+) AGCATA/TACACT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TOMM7 (22852251 - 22862470 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TOMM7:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv272529CNV Insertion20981092
    esv269276CNV Insertion20981092
    esv2467344CNV Insertion19546169
    nsv526131CNV Loss19592680
    dgv2070e1CNV Complex17122850
    nsv7393OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TOMM7 for disorders           About MalaCards
    OMIM gene information: 607980    OMIM disorders: --


    TOMM7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TOMM7
    Human Genome Epidemiology (HuGE) Navigator: TOMM7 (2 documents)

    Export disorders for TOMM7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TOMM7 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with TOMM7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane. (PubMed id 12198123)1, 2, 3 Johnston A.J.... Ryan M.T. (2002)
    2. Cloning and characterization of the human novel gene encoding 6.2 kDa protein highly expressed upon ultraviolet irradiation in DNA-PK- deleted human glioma M059J cells. (PubMed id 10647823)1, 2, 3 Lee J.-S. (1999)
    3. Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. (PubMed id 18331822)1, 2, 9 Kato H. and Mihara K. (2008)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54543 HGNC: 21648 AceView: TOMM7 Ensembl:ENSG00000196683 euGenes: HUgn54543
    ECgene: TOMM7 H-InvDB: TOMM7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TOMM7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TOMM7 gene:
    Search GeneIP for patents involving TOMM7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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