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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TOMM7 Gene

protein-coding   GIFtS: 50
GCID: GC07M022818

translocase of outer mitochondrial membrane 7 homolog (yeast)

  Search for TOMM7
in our new
 Human Malady Compendium 
Biological research products
for TOMM7
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Translocase Of Outer Mitochondrial Membrane 7 Homolog (Yeast)1 2
Translocase Of Outer Membrane 7 KDa Subunit Homolog2 3
TOM72 3
6.2 Kd Protein2
Mitochondrial Import Receptor Subunit TOM7 Homolog2
TOMM073

External Ids:    HGNC: 216481   Entrez Gene: 545432   Ensembl: ENSG000001966837   OMIM: 6079805   UniProtKB: Q9P0U13   

Export aliases for TOMM7 gene to outside databases

Previous GC identifers: GC07M022560 GC07M022594 GC07M022626 GC07M022735


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TOMM7:
This gene encodes a subunit of the translocase of the outer mitochondrial membrane. The encoded protein regulates the
assembly and stability of the translocase complex. (provided by RefSeq, Oct 2012)

UniProtKB/Swiss-Prot: TOM7_HUMAN, Q9P0U1
Function: Required for assembly and stability of the TOM complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TOMM7 gene promoter:
         ISGF-3   LHX3b/Lhx3b   Pbx1a   POU3F1   Evi-1   E47   HFH-1   LHX3a/Lhx3a   Hand1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTOMM7 promoter sequence
   Search SABiosciences Chromatin IP Primers for TOMM7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOMM7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.3   Ensembl cytogenetic band:  7p15.3   HGNC cytogenetic band: 7p15.3

TOMM7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOMM7 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M022818:  view genomic region     (about GC identifiers)

Start:
22,852,251 bp from pter      End:
22,862,470 bp from pter
Size:
10,220 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 22,903,376-22,913,545     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TOM7_HUMAN, Q9P0U1 (See protein sequence)
Recommended Name: Mitochondrial import receptor subunit TOM7 homolog  
Size: 55 amino acids; 6248 Da
Subunit: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which
consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70)
Subcellular location: Mitochondrion outer membrane; Single-pass membrane protein
Secondary accessions: O95939

Explore the universe of human proteins at neXtProt for TOMM7: NX_Q9P0U1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P0U1

  • TOMM7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_061932.1  
    ENSEMBL proteins: 
     ENSP00000351214   ENSP00000385203   ENSP00000361970  
    Reactome Protein details: Q9P0U1
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    Uscn Proteins for TOMM7

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA12198123
    GO:0005741mitochondrial outer membrane ----
    GO:0005742mitochondrial outer membrane translocase complex IDA12198123
    GO:0016021integral to membrane IEA--


    TOMM7 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TOMM7 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR012621 Tom7

    Graphical View of Domain Structure for InterPro Entry Q9P0U1

    ProtoNet protein and cluster: Q9P0U1

    1 Blocks protein family: IPB012621 TOM7

    UniProtKB/Swiss-Prot: TOM7_HUMAN, Q9P0U1
    Similarity: Belongs to the Tom7 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TOM7_HUMAN, Q9P0U1
    Function: Required for assembly and stability of the TOM complex

    miRNA
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    Inhib. RNA
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12198123
    GO:0008320protein transmembrane transporter activity TAS15644312
    GO:0015450P-P-bond-hydrolysis-driven protein transmembrane transporter activity IEA--


    TOMM7 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Mitochondrial Protein Import
    Mitochondrial Protein Import1.00
    2Asparagine N-linked glycosylation
    Metabolism of proteins0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for TOMM7
        Mitochondrial Protein Import
    Metabolism of proteins



    TOMM7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TOMM7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/27 Interacting proteins for TOMM7 (Q9P0U11, 3 ENSP000003512144) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TOMM22Q9NS691, 3, ENSP000002160344EBI-1180558,EBI-1180569 I2D: score=2 STRING: ENSP00000216034
    TOMM40O960083, ENSP000002524874I2D: score=2 STRING: ENSP00000252487
    DNAJC19ENSP000003720054STRING: ENSP00000372005
    GRPEL1ENSP000002649544STRING: ENSP00000264954
    MTX1ENSP000003573604STRING: ENSP00000357360
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion TAS15644312
    GO:0006886intracellular protein transport ----
    GO:0044267cellular protein metabolic process TAS--


    TOMM7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TOMM7
    Search CenterWatch for drugs/clinical trials and news about TOMM7 / TOM7 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TOMM7 gene: 
    NM_019059.3  

    Unigene Cluster for TOMM7:

    Translocase of outer mitochondrial membrane 7 homolog (yeast)
    Hs.112318  [show with all ESTs]
    Unigene Representative Sequence: CD048567
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000463284 ENST00000358435(uc003svk.3) ENST00000483581 ENST00000405021
    ENST00000372879 ENST00000496129

    miRNA
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    Inhib. RNA
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    Clone
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOMM7

    Additional cDNA sequence: 

    AF086336.1 AF150733.1 AJ011007.1 AK026520.1 BC001732.1 BC071973.1 CR456960.1 

    15 DOTS entries:

    DT.100861392  DT.87017313  DT.102829396  DT.100689421  DT.120878158  DT.100806946  DT.100009074  DT.100057581 
    DT.121049623  DT.87001802  DT.92475107  DT.40286998  DT.95288390  DT.100891992  DT.121049619 

    652 AceView cDNA sequences (see top 24):

    AA864985 BG760143 BM764622 AA320314 AA640125 BQ670128 BQ935404 BE731106 
    AA872028 BQ056695 AA983421 F30546 BG761632 AA385602 AA516008 F36124 
    AI022931 BQ683453 F25361 AA314957 CR599481 BU164304 F31370 F34876 
    BQ950878 AW440882 BU174933 BQ066463 BU166579 AJ571784 BQ935480 F34828 
    BF025770 BC001732 BM849294 AW772838 AA088601 BU174237 BE512790 AJ713108 
    AA635536 BU726515 BM840487 BU528966 BM760303 BG219908 BQ214575 BQ642847 
    AI052423 BM840392 CD674314 C02394 BI710991 BQ680297 BU527334 BE391434 
    F27385 BM738805 AI004087 F31347 N41855 BM673042 F29525 BQ226213 
    BM761830 AA878329 AA654904 BQ673586 AA973392 BM693017 BU191705 CA866806 
    BU951799 CD251574 BU526762 BE166926 BX345336 BG761411 BE166905 AA770267 
    CB958387 F28421 BU589437 BG685085 BG291300 F25330 AW131452 BF939976 
    F19555 AW261972 F31130 BF664386 AA576245 BG769466 F27735 AL706670 
    BE383821 AA876351 BE122909 AA657783 BE294417 BC071973 AI470256 F20666 
    F32299 BE207548 BG684498 AI081267 AW079431 BM010691 BQ013721 AI499169 
    BG756916 BM838735 AA211509 F26026 BE878782 F27895 BM046910 AA317851 
    F35517 F35977 BM558566 BF129131 BE675529 F26003 AA508524 AA363902 
    AJ011007 AA873399 CD176242 BG754182 BF974825 AA669713 AA568254 BU502560 
    F35560 AA367301 CD173105 CD516352 NM_019059 BU501847 BQ672353 F37570 
    BE392599 AJ571936 F24766 F33279 BG759782 AI268835 CN484620 BI256614 
    CK820524 BG340737 BM045052 F33538 AA601970 F28746 BM791643 BI117167 
    AA157424 BM737763 AL120461 AF150733 BF224263 BQ677632 BI493285 CA455332 
    F25155 BE302745 BF974126 F28781 AI031923 BF446391 F28802 AA723130 
    BF975730 AA729891 BU071895 BE786943 F25934 BM044474 F25748 W73149 
    AA148508 AW518526 CK903276 BU899302 AI311314 CA943824 F27059 BM689384 
    BG756969 CD512737 CB156667 AW006968 BG423051 AA157326 BM009928 AI824129 
    BU542471 BG472261 AI817693 BQ549907 BG470826 AW273628 AA557367 F37503 
    AA733085 BI160960 BQ052333 AA737264 AA306205 AA644209 AW008704 BM504715 
    BP373387 F28367 BF026840 AK026520 AA864465 AI692598 AA961025 AI279125 
    BG332645 BE394515 AW161266 F26838 F19187 BE166932 BM555777 F21240 
    AJ573236 BG766143 CB109376 AA515132 BI756207 BQ957485 AA491805 AA365883 
    BG030532 BG150499 BG774281 AF086336 BE166928 F37642 AA186477 AA344802 
    BF211064 AA651971 AA194521 AA468925 AA040209 BG764726 W33001 F28338 
    BF312854 BQ694253 BQ778264 AA961415 BG944367 BE166927 BM505037 AI086612 
    AI832508 CD175150 BU858772 CD555983 AA894438 F31304 BG107438 F33860 
    BF182810 AW877529 BU539929 F32436 F27946 AW797829 F28324 AI004544 
    AA969469 F34417 AI073649 CR456960 AW877522 F23569 F34000 F27502 
    F32478 AA559144 BI490527 AA211557 CA866539 F30626 F24994 BE166861 
    AJ574576 BQ021437 BM788501 F25625 AA352512 F30534 BU580975 BG501107 
    AA095201 BU567108 F29715 AA831379 BU580518 BE727673 AA995548 AA936775 
    AA632304 AA215947 BE076922 AA320703 BU564274 AA156616 BE898486 BU588331 
    AA635395 CD388375 AA559160 F22523 W65375 AA911786 F34117 AW168966 
    BG335819 BG684703 AI300884 AA186406 BU860663 BI669114 F25201 CD175635 
    CD175043 AA652224 BM691167 BE734067 F28336 F25149 BE166912 AA569094 
    AA581779 CD247270 CA395995 CD385337 BI598723 F37740 CB998618 CD385131 
    CD173697 AJ708187 CD173996 CD387548 CD246383 BQ010889 F33527 AJ707676 
    AA838831 AW877456 CD250338 CD246229 CD174057 BE877798 CD386879 AA805865 
    CD248279 CD175708 AW877524 CD385371 CD387468 AW840534 CD385105 CD173552 
    BG211489 CD385278 CD389241 AJ711274 CD556494 CD387321 BE076754 CD389969 
    AA577944 AA503188 CD249492 CD175089 BU860904 F25875 AA714594 CD175970 
    BM761820 CD247405 AA229239 BU944961 CF123592 BM047712 CD386740 BG108760 
    CD174353 AA485318 CD174271 BQ943840 AA558876 CD175711 BQ012293 CD248200 
    CD174978 CD248894 CF529798 BM915705 AA384124 AJ708084 AW872496 BU533301 
    CD177647 BG716013 CD172708 AW798130 CD249365 CD175775 CD512130 CD384875 
    CB997799 CD385633 CD250007 F24614 BI598162 CD389880 CD386526 CD177064 
    CD249035 BI668404 CD385209 F29082 CD389960 BF351394 BG251791 AW877523 
    CD386131 F33873 CD388715 CD389440 BM546471 AW872518 BP343521 CD386050 
    CD176162 CD389641 BQ012614 AA570050 CD173738 BI766949 F37088 CD172955 
    CD389506 CD250132 CD249342 CD174250 BQ011368 CD387868 F28309 CD175515 
    CD639151 CB159251 CD388543 CD389602 AI479081 CD385354 AA578105 CD174163 
    CD173416 CD386130 CD556068 CD555931 F30623 CD250080 AA658921 CD176187 
    CD175237 CD249695 F24768 CD389456 BU953475 AA484649 CD174535 CD173687 
    CD176630 AW877528 BF967262 CD385320 CD249495 F21221 CA310793 F37636 
    BQ671600 W07256 BG218906 CB958503 F23563 BP871277 CD174600 BM704944 
    CD175545 CD173849 F37648 BG701405 CD629644 CD386518 AA661467 BE045269 
    BX416682 AW651775 AW795374 CD176432 BG207316 CD173472 BE045278 CD173412 
    F32843 F36137 BQ672282 BG753955 AA374033 F28208 BU601187 BM916052 
    CD172806 BG214176 CD173928 CD175556 AW957295 CD174198 CD175430 AI500606 
    F37828 CD249662 CD173432 AW877462 T25736 AA484704 CF995297 BI553551 
    CD176510 BE166866 CD248049 BE207562 BU588055 F26040 N83996 CD384986 
    F33149 BU899205 AA714452 CD384840 F23486 BU955697 BI551924 BU502427 
    AW877458 AW103356 BF245098 CD172758 CD172653 AA658948 CD174360 AW772589 
    T47466 CD173369 CD175879 AA047718 BU961001 CF123829 AW877537 BF087991 
    AJ710038 CD387458 CD107086 CD386981 BM853215 BG489506 BX416681 AI749017 
    AJ712467 CD249986 BG182445 BI824148 BG474914 AW795225 BG196460 AA680245 
    BG150928 BU787532 BI767357 BF132499 BU535806 AW516726 BF107507 BE166917 
    BI756269 CD247605 BG676902 BG396680 BQ334902 BG475379 BP373213 BG769435 
    BF973104 BE076866 CD249942 BU597837 BP374850 BU930177 CD174070 BG770171 
    BU945026 BF974227 BG473380 BU566721 BX431338 BQ306204 BG206813 BE774639 
    CB146447 AA862649 F37833 BE378383 AW840571 CD629645 BE166913 BQ306191 
    CD388112 BI756926 F35099 AV701243 AV701246 BG686774 BU932760 BF680825 
    BM045128 CD387730 BE769376 BE254343 CD247663 AI557912 BE774628 CD385108 
    CD389667 BG341285 BG339049 CD387047 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TOMM7    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b
    SP1:                          -     -               
    SP2:                          -                     
    SP3:                    -     -     -               
    SP4:                                                


    ECgene alternative splicing isoforms for TOMM7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TOMM7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAGATGTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See TOMM7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TOMM7

    SOURCE GeneReport for Unigene cluster: Hs.112318
        SABiosciences Custom PCR Arrays for TOMM7
    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TOMM7 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tomm71 , 5 translocase of outer mitochondrial membrane 7 homolog more1, 5 90.3(n)1
    94.55(a)1
      5 (10.48 cM)5
    661691  NM_025394.31  NP_079670.11 
     238389445 
    chicken
    (Gallus gallus)
    Aves TOMM71 translocase of outer mitochondrial membrane 7 homolog more 80.61(n)
    87.27(a)
      420610  NM_001199617.1  NP_001186546.1 
    lizard
    (Anolis carolinensis)
    Reptilia TOMM76
    --
    82(a)
    1 ↔ 1
    6(30314884-30321641)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.253772 Xenopus laevis transcribed sequence with moderate similarity more 73.74(n)    BJ051727.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tomm71 translocase of outer mitochondrial membrane 7 homolog more 76.97(n)
    83.64(a)
      751649  NM_001161487.1  NP_001154959.1 


    ENSEMBL Gene Tree for TOMM7 (if available)
    TreeFam Gene Tree for TOMM7 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TOMM7 gene
    1 SIMAP similar gene for TOMM7 using alignment to 3 protein entries:     TOM7_HUMAN (see all proteins):
    TOM7

    TOMM7 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TOMM7
    PGOHUM00000245628 PGOHUM00000235547


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/268 NCBI SNPs in TOMM7 are shown (see all 268    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs732782661,2
    C,--22851877(+) CCCAAC/TAGGCT 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs171472901,2
    C,F,H,--22851967(+) TAGAAG/AAACGG 1 -- ds50018Minor allele frequency- A:0.15NA NS WA EA 694
    rs1812107961,2
    --22851970(+) AAGAAC/TGGAAA 1 -- ds50010--------
    rs1866662791,2
    --22851989(+) TAATAA/GAAGTA 1 -- ds50010--------
    rs1449771291,2
    --22852049(+) AACTAC/GTTTCC 1 -- ds50010--------
    rs1125994041,2
    C,--22852424(+) AAAAAT/ATTTTT 1 -- ut311Minor allele frequency- A:0.50WA 2
    rs778936811,2
    F,--22852436(+) ATATCG/ATGATC 1 -- ut311Minor allele frequency- A:0.06WA 118
    rs22407281,2
    C,F,--22852499(-) TGTGTA/GTACCT 1 -- ut31 ese312Minor allele frequency- G:0.42NA WA CSA EA 376
    rs22407271,2
    C,F,H,--22852512(-) AACAGA/GGAATT 1 -- ut31 ese323Minor allele frequency- G:0.45EA NS NA WA CSA 3832
    rs10544711,2
    C,F,A,H,--22852643(-) GTGGAA/TCTTGT 1 -- ut3196Minor allele frequency- T:0.48EA NS MN NA PA EU CA WA CSA 5990

    HapMap Linkage Disequilibrium report for TOMM7 (22852251 - 22862470 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for TOMM7
         1 CNV: 3670
         1 Indel: 99890

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TOMM7 for disorders           About MalaCards

    TOMM7 for disorders           About GeneDecksing

    OMIM gene information: 607980    OMIM disorders: --

    Human Genome Epidemiology (HuGE) Navigator: TOMM7 (2 documents)

    Export disorders for TOMM7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TOMM7 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with TOMM7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane. (PubMed id 12198123)1, 2, 3 Johnston A.J.... Ryan M.T. (2002)
    2. Cloning and characterization of the human novel gene encoding 6.2 kDa protein highly expressed upon ultraviolet irradiation in DNA-PK- deleted human glioma M059J cells. (PubMed id 10647823)1, 2, 3 Lee J.-S. (1999)
    3. Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. (PubMed id 18331822)1, 2, 9 Kato H. and Mihara K. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54543 HGNC: 21648 AceView: TOMM7 Ensembl:ENSG00000196683 euGenes: HUgn54543
    ECgene: TOMM7 H-InvDB: TOMM7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TOMM7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TOMM7 gene:
    Search GeneIP for patents involving TOMM7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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