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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TOMM7 Gene

protein-coding   GIFtS: 50
GCID: GC07M022818

translocase of outer mitochondrial membrane 7 homolog (yeast)
  Search for TOMM7
in
MalaCards
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 Human Malady Compendium 
Biological research products
for TOMM7    

Aliases
for TOMM7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Translocase Of Outer Mitochondrial Membrane 7 Homolog (Yeast)1 2
Translocase Of Outer Membrane 7 KDa Subunit Homolog2 3
TOM72 3
6.2 Kd Protein2
Mitochondrial Import Receptor Subunit TOM7 Homolog2
TOMM073

External Ids:    HGNC: 216481   Entrez Gene: 545432   Ensembl: ENSG000001966837   OMIM: 6079805   UniProtKB: Q9P0U13   

Export aliases for TOMM7 gene to outside databases

Previous GC identifers: GC07M022560 GC07M022594 GC07M022626 GC07M022735


Summaries
for TOMM7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TOMM7:
This gene encodes a subunit of the translocase of the outer mitochondrial membrane. The encoded protein regulates the
assembly and stability of the translocase complex. (provided by RefSeq, Oct 2012)

UniProtKB/Swiss-Prot: TOM7_HUMAN, Q9P0U1
Function: Required for assembly and stability of the TOM complex




Genomic Views
for TOMM7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TOMM7 gene promoter:
         ISGF-3   LHX3b/Lhx3b   Pbx1a   POU3F1   Evi-1   E47   HFH-1   LHX3a/Lhx3a   Hand1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TOMM7 promoter sequence
   Search SABiosciences Chromatin IP Primers for TOMM7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOMM7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.3   Ensembl cytogenetic band:  7p15.3   HGNC cytogenetic band: 7p15.3

TOMM7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOMM7 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M022818:  view genomic region     (about GC identifiers)

Start:
 22,852,251 bp from pter      End:
 22,862,470 bp from pter
Size:
 10,220 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 22,903,376-22,913,545     

Proteins
for TOMM7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TOM7_HUMAN, Q9P0U1 (See protein sequence)
Recommended Name: Mitochondrial import receptor subunit TOM7 homolog  
Size: 55 amino acids; 6248 Da
Subunit: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which
consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70)
Subcellular location: Mitochondrion outer membrane; Single-pass membrane protein
Secondary accessions: O95939

Explore the universe of human proteins at neXtProt for TOMM7: NX_Q9P0U1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P0U1

    • TOMM7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_061932.1  
    ENSEMBL proteins: 
     ENSP00000351214   ENSP00000385203   ENSP00000361970  
    Reactome Protein details: Q9P0U1
    Human Recombinant Protein Products: 
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    Uscn Proteins for TOMM7

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA12198123
    GO:0005741mitochondrial outer membrane ----
    GO:0005742mitochondrial outer membrane translocase complex IDA12198123
    GO:0016021integral to membrane IEA--


    TOMM7 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TOMM7

    Protein Domains /
    Families
    for TOMM7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TOMM7 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR012621 Tom7

    Graphical View of Domain Structure for InterPro Entry Q9P0U1

    ProtoNet protein and cluster: Q9P0U1

    1 Blocks protein family: IPB012621 TOM7

    UniProtKB/Swiss-Prot: TOM7_HUMAN, Q9P0U1
    Similarity: Belongs to the Tom7 family


    Function
    for TOMM7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TOM7_HUMAN, Q9P0U1
    Function: Required for assembly and stability of the TOM complex

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for TOMM7

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TOMM7

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12198123
    GO:0008320protein transmembrane transporter activity TAS15644312
    GO:0015450P-P-bond-hydrolysis-driven protein transmembrane transporter activity IEA--


    TOMM7 for ontologies           About GeneDecksing



    Pathways & Interactions
    for TOMM7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Mitochondrial Protein Import
    		Mitochondrial Protein Import1.00
    2Asparagine N-linked glycosylation
    		Metabolism of proteins0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for TOMM7
        Mitochondrial Protein Import
    Metabolism of proteins



    TOMM7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TOMM7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/27 Interacting proteins for TOMM7 (Q9P0U11, 3 ENSP000003512144) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TOMM22Q9NS691, 3, ENSP000002160344EBI-1180558,EBI-1180569 I2D: score=2 STRING: ENSP00000216034
    TOMM40O960083, ENSP000002524874I2D: score=2 STRING: ENSP00000252487
    DNAJC19ENSP000003720054STRING: ENSP00000372005
    GRPEL1ENSP000002649544STRING: ENSP00000264954
    MTX1ENSP000003573604STRING: ENSP00000357360
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion TAS15644312
    GO:0006886intracellular protein transport ----
    GO:0044267cellular protein metabolic process TAS--


    TOMM7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TOMM7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TOMM7
    Search CenterWatch for drugs/clinical trials and news about TOMM7 / TOM7 

    Transcripts
    for TOMM7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TOMM7 gene: 
    NM_019059.3  

    Unigene Cluster for TOMM7:

    Translocase of outer mitochondrial membrane 7 homolog (yeast)
    Hs.112318  [show with all ESTs]
    Unigene Representative Sequence: CD048567
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000463284 ENST00000358435(uc003svk.3) ENST00000483581 ENST00000405021
    ENST00000372879 ENST00000496129

    miRNA
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    Inhib. RNA
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    Primer
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    Additional cDNA sequence: 

    AF086336.1 AF150733.1 AJ011007.1 AK026520.1 BC001732.1 BC071973.1 CR456960.1 

    15 DOTS entries:

    DT.100861392  DT.87017313  DT.102829396  DT.100689421  DT.120878158  DT.100806946  DT.100009074  DT.100057581 
    DT.121049623  DT.87001802  DT.92475107  DT.40286998  DT.95288390  DT.100891992  DT.121049619 

    24/652 AceView cDNA sequences (see all 652):

    AA864985 BG760143 BM764622 AA320314 AA640125 BQ670128 BQ935404 BE731106 
    AA872028 BQ056695 AA983421 F30546 BG761632 AA385602 AA516008 F36124 
    AI022931 BQ683453 F25361 AA314957 CR599481 BU164304 F31370 F34876 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TOMM7    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b
    SP1:                          -     -               
    SP2:                          -                     
    SP3:                    -     -     -               
    SP4:                                                


    ECgene alternative splicing isoforms for TOMM7

    Expression
    for TOMM7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TOMM7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAGATGTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See TOMM7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TOMM7

    SOURCE GeneReport for Unigene cluster: Hs.112318
        SABiosciences Custom PCR Arrays for TOMM7
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    In Situ
    Assay Products:     
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    Orthologs
    for TOMM7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TOMM7 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tomm71 , 5 translocase of outer mitochondrial membrane 7 homolog more1, 5 90.3(n)1
    94.55(a)1    		   5 (10.48 cM)5
    661691  NM_025394.31  NP_079670.11 
     238389445 
    chicken
    (Gallus gallus)    		 Aves TOMM71 translocase of outer mitochondrial membrane 7 homolog more 80.61(n)
    87.27(a)    		   420610  NM_001199617.1  NP_001186546.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TOMM76
    		 --
    		 82(a)
    		 1 ↔ 1
    		 6(30314884-30321641)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.253772 Xenopus laevis transcribed sequence with moderate similarity more 73.74(n)    BJ051727.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii tomm71 translocase of outer mitochondrial membrane 7 homolog more 76.97(n)
    83.64(a)    		   751649  NM_001161487.1  NP_001154959.1 


    ENSEMBL Gene Tree for TOMM7 (if available)
    TreeFam Gene Tree for TOMM7 (if available) 

    Paralogs
    for TOMM7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TOMM7 gene
    1 SIMAP similar gene for TOMM7 using alignment to 3 protein entries:     TOM7_HUMAN (see all proteins):
    TOM7

    TOMM7 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TOMM7
    PGOHUM00000245628 PGOHUM00000235547


    Genomic Variants
    for TOMM7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/268 NCBI SNPs in TOMM7 are shown (see all 268)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs732782661,2
    		C,--22851877(+) CCCAAC/TAGGCT 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs171472901,2
    		C,F,H,--22851967(+) TAGAAG/AAACGG 1 -- ds50018Minor allele frequency- A:0.15NA NS WA EA 694
    rs1812107961,2
    		--22851970(+) AAGAAC/TGGAAA 1 -- ds50010--------
    rs1866662791,2
    		--22851989(+) TAATAA/GAAGTA 1 -- ds50010--------
    rs1449771291,2
    		--22852049(+) AACTAC/GTTTCC 1 -- ds50010--------
    rs1125994041,2
    		C,--22852424(+) AAAAAT/ATTTTT 1 -- ut311Minor allele frequency- A:0.50WA 2
    rs778936811,2
    		F,--22852436(+) ATATCG/ATGATC 1 -- ut311Minor allele frequency- A:0.06WA 118
    rs22407281,2
    		C,F,--22852499(-) TGTGTA/GTACCT 1 -- ut31 ese312Minor allele frequency- G:0.42NA WA CSA EA 376
    rs22407271,2
    		C,F,H,--22852512(-) AACAGA/GGAATT 1 -- ut31 ese323Minor allele frequency- G:0.45EA NS NA WA CSA 3832
    rs10544711,2
    		C,F,A,H,--22852643(-) GTGGAA/TCTTGT 1 -- ut3196Minor allele frequency- T:0.48EA NS MN NA PA EU CA WA CSA 5990

    HapMap Linkage Disequilibrium report for TOMM7 (22852251 - 22862470 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for TOMM7
         1 CNV: 3670
         1 Indel: 99890

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOMM7
    DNA2.0 Custom Variant and Variant Library Synthesis for TOMM7

    Disorders / Diseases
    for TOMM7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TOMM7 for disorders           About MalaCards

    TOMM7 for disorders           About GeneDecksing

    OMIM gene information: 607980    OMIM disorders: --

    Human Genome Epidemiology (HuGE) Navigator: TOMM7 (2 documents)

    Export disorders for TOMM7 gene to outside databases

    Publications
    for TOMM7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TOMM7 gene, integrated from 9 sources (see all 16) (see top 10):
    (articles sorted by number of sources associating them with TOMM7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane. (PubMed id 12198123)1, 2, 3 Johnston A.J.... Ryan M.T. (2002)
    2. Cloning and characterization of the human novel gene encoding 6.2 kDa protein highly expressed upon ultraviolet irradiation in DNA-PK- deleted human glioma M059J cells. (PubMed id 10647823)1, 2, 3 Lee J.-S. (1999)
    3. Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. (PubMed id 18331822)1, 2, 9 Kato H. and Mihara K. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    11. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    12. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    External Searches for TOMM7 gene

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    Genome Databases showing TOMM7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54543 HGNC: 21648 AceView: TOMM7 Ensembl:ENSG00000196683 euGenes: HUgn54543
    ECgene: TOMM7 H-InvDB: TOMM7

    Other Databases showing TOMM7 gene

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    Specialized Databases showing TOMM7 gene

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    PharmGKB entry for TOMM7 Pharmacogenomics, SNPs, Pathways

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