TOMM7 Gene
protein-coding GIFtS: 50
GCID: GC07M022818
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|
translocase of outer mitochondrial membrane 7 homolog (yeast)
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Aliases
for TOMM7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Translocase Of Outer Mitochondrial Membrane 7 Homolog (Yeast)1 2 | | Translocase Of Outer Membrane 7 KDa Subunit Homolog2 3 | | TOM72 3 | | 6.2 Kd Protein2 | | Mitochondrial Import Receptor Subunit TOM7 Homolog2 | | TOMM073 |
Export aliases for TOMM7 gene to outside databasesPrevious GC identifers: GC07M022560 GC07M022594 GC07M022626 GC07M022735 |
Summaries
for TOMM7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TOMM7:
This gene encodes a subunit of the translocase of the outer mitochondrial membrane. The encoded protein regulates theassembly and stability of the translocase complex. (provided by RefSeq, Oct 2012)
UniProtKB/Swiss-Prot: TOM7_HUMAN, Q9P0U1Function: Required for assembly and stability of the TOM complex
|
Genomic Views
for TOMM7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TOMM7 gene promoter:
ISGF-3 LHX3b/Lhx3b Pbx1a POU3F1 Evi-1 E47 HFH-1 LHX3a/Lhx3a Hand1 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for TOMM7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOMM7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p15.3 Ensembl cytogenetic band: 7p15.3 HGNC cytogenetic band: 7p15.3TOMM7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M022818: view genomic region
(about GC identifiers)
Start:
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22,852,251 bp from pter |
End:
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22,862,470 bp from pter |
Size:
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10,220 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 22,903,376-22,913,545 |
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Proteins
for TOMM7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TOM7_HUMAN, Q9P0U1 (See
protein sequence)Recommended Name: Mitochondrial import receptor subunit TOM7 homolog Size: 55 amino acids; 6248 Da
Subunit: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) whichconsists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70)
Subcellular location: Mitochondrion outer membrane; Single-pass membrane protein
Secondary accessions: O95939Explore the universe of human proteins at neXtProt for TOMM7: NX_Q9P0U1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P0U1
TOMM7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061932.1
ENSEMBL proteins: ENSP00000351214 ENSP00000385203 ENSP00000361970 Reactome Protein details: Q9P0U1
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
TOMM7 for ontologies About GeneDecksing
TOMM7 Antibody Products:
Assay Products for TOMM7: |
Protein
Domains /
Families
for TOMM7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TOMM7 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9P0U1ProtoNet protein and cluster: Q9P0U1 1 Blocks protein family: IPB012621 TOM7
UniProtKB/Swiss-Prot: TOM7_HUMAN, Q9P0U1Similarity: Belongs to the Tom7 family |
Function
for TOMM7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TOM7_HUMAN, Q9P0U1Function: Required for assembly and stability of the TOM complex
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TOMM7 (NM_014820) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TOMM7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM7 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
TOMM7 for ontologies About GeneDecksing
|
Pathways & Interactions
for TOMM7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Mitochondrial Protein Import | | | 2 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for TOMM7
TOMM7 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TOMM7
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/27 Interacting proteins for TOMM7 (Q9P0U11, 3 ENSP000003512144) via UniProtKB, MINT, STRING, and/or I2D (see all 27)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006626 | protein targeting to mitochondrion |
TAS | 15644312 | | GO:0006886 | intracellular protein transport |
-- | -- | | GO:0044267 | cellular protein metabolic process |
TAS | -- |
TOMM7 for ontologies About GeneDecksing
|
Drugs & Compounds
for TOMM7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TOMM7
Search CenterWatch for drugs/clinical trials and news about TOMM7 / TOM7
|
Transcripts
for TOMM7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TOMM7 gene: NM_019059.3 Unigene Cluster for TOMM7: Translocase of outer mitochondrial membrane 7 homolog (yeast) Hs.112318 [show with all ESTs]Unigene Representative Sequence: CD0485676 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000463284 ENST00000358435(uc003svk.3) ENST00000483581 ENST00000405021
ENST00000372879 ENST00000496129
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TOMM7 (NM_014820) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TOMM7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM7 |
Additional cDNA sequence: AF086336.1 AF150733.1 AJ011007.1 AK026520.1 BC001732.1 BC071973.1 CR456960.1 15 DOTS entries: DT.100861392 DT.87017313 DT.102829396 DT.100689421 DT.120878158 DT.100806946 DT.100009074 DT.100057581 DT.121049623 DT.87001802 DT.92475107 DT.40286998 DT.95288390 DT.100891992 DT.121049619 24/652 AceView cDNA sequences (see all 652): AA864985 BG760143 BM764622 AA320314 AA640125 BQ670128 BQ935404 BE731106 AA872028 BQ056695 AA983421 F30546 BG761632 AA385602 AA516008 F36124 AI022931 BQ683453 F25361 AA314957 CR599481 BU164304 F31370 F34876
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for TOMM7 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b |
|---|
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| SP1: | | | | | | | | | - | | - | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TOMM7
|
Expression
for TOMM7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TOMM7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAGATGTGT
About this image
See TOMM7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TOMM7
SOURCE GeneReport for Unigene cluster: Hs.112318
SABiosciences Custom PCR Arrays for TOMM7
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TOMM7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOMM7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOMM7 |
Orthologs
for TOMM7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TOMM7 gene from 5/13 species (see all 13) About this table
ENSEMBL Gene Tree for TOMM7 (if available)
TreeFam Gene Tree for TOMM7 (if available) |
Paralogs
for TOMM7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TOMM7 gene
1 SIMAP similar gene for TOMM7 using alignment to 3 protein entries: TOM7_HUMAN (see all proteins):TOM7
TOMM7 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for TOMM7
PGOHUM00000245628 PGOHUM00000235547
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Genomic Variants
for TOMM7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TOMM7 (22852251 - 22862470 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TOMM7
1 CNV: 3670
1 Indel: 99890 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TOMM7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TOMM7 for disorders About MalaCards
TOMM7 for disorders About GeneDecksing
OMIM gene information: 607980
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: TOMM7 (2 documents)
Export disorders for TOMM7 gene to outside databases
|
Publications
for TOMM7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TOMM7 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with TOMM7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane. (PubMed id 12198123)1, 2, 3 Johnston A.J.... Ryan M.T. (2002)
- Cloning and characterization of the human novel gene encoding 6.2 kDa protein highly expressed upon ultraviolet irradiation in DNA-PK- deleted human glioma M059J cells. (PubMed id 10647823)1, 2, 3 Lee J.-S. (1999)
- Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. (PubMed id 18331822)1, 2, 9 Kato H. and Mihara K. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for TOMM7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TOMM7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TOMM7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TOMM7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TOMM7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TOMM7 gene:
Search GeneIP for patents involving TOMM7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TOMM7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TOMM7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TOMM7 | | Browse OriGene genome-wide validated SYBR primer pairs | | | OriGene Protein Over-expression Lysate for TOMM7 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TOMM7 | | OriGene 3'-UTR Clone for TOMM7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TOMM7 | | OriGene Custom Protein Services for TOMM7 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TOMM7 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOMM7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOMM7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOMM7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOMM7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOMM7 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TOMM7 |
| |  |  |  |  | | | | |
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 | | | TOMM7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for TOMM7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM7 |
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