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Aliases for TOMM7 Gene

Aliases for TOMM7 Gene

  • Translocase Of Outer Mitochondrial Membrane 7 Homolog (Yeast) 2 3
  • Translocase Of Outer Membrane 7 KDa Subunit Homolog 3 4
  • TOM7 3 4
  • Mitochondrial Import Receptor Subunit TOM7 Homolog 3
  • 6.2 Kd Protein 3
  • TOMM07 4

External Ids for TOMM7 Gene

Summaries for TOMM7 Gene

Entrez Gene Summary for TOMM7 Gene

  • This gene encodes a subunit of the translocase of the outer mitochondrial membrane. The encoded protein regulates the assembly and stability of the translocase complex. [provided by RefSeq, Oct 2012]

GeneCards Summary for TOMM7 Gene

TOMM7 (Translocase Of Outer Mitochondrial Membrane 7 Homolog (Yeast)) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Mitochondrial Protein Import. GO annotations related to this gene include protein transmembrane transporter activity.

UniProtKB/Swiss-Prot for TOMM7 Gene

  • Required for assembly and stability of the TOM complex. Positive regulator of PARK2 translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOMM7 Gene

Genomics for TOMM7 Gene

Genomic Location for TOMM7 Gene

Start:
22,812,628 bp from pter
End:
22,822,852 bp from pter
Size:
10,225 bases
Orientation:
Minus strand

Genomic View for TOMM7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TOMM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOMM7 Gene

Regulatory Elements for TOMM7 Gene

Proteins for TOMM7 Gene

  • Protein details for TOMM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0U1-TOM7_HUMAN
    Recommended name:
    Mitochondrial import receptor subunit TOM7 homolog
    Protein Accession:
    Q9P0U1
    Secondary Accessions:
    • O95939

    Protein attributes for TOMM7 Gene

    Size:
    55 amino acids
    Molecular mass:
    6248 Da
    Quaternary structure:
    • Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).

neXtProt entry for TOMM7 Gene

Proteomics data for TOMM7 Gene at MOPED

Post-translational modifications for TOMM7 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys17

Other Protein References for TOMM7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TOMM7 Gene

Domains for TOMM7 Gene

Protein Domains for TOMM7 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

TOM7_HUMAN
Family:
  • Belongs to the Tom7 family.:
    • Q9P0U1
genes like me logo Genes that share domains with TOMM7: view

No data available for Gene Families for TOMM7 Gene

Function for TOMM7 Gene

Molecular function for TOMM7 Gene

UniProtKB/Swiss-Prot Function: Required for assembly and stability of the TOM complex. Positive regulator of PARK2 translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria.

Gene Ontology (GO) - Molecular Function for TOMM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12198123
GO:0008320 protein transmembrane transporter activity TAS 15644312
genes like me logo Genes that share ontologies with TOMM7: view

miRNA for TOMM7 Gene

miRTarBase miRNAs that target TOMM7

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TOMM7 Gene

Localization for TOMM7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOMM7 Gene

Mitochondrion outer membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TOMM7 Gene COMPARTMENTS Subcellular localization image for TOMM7 gene
Compartment Confidence
mitochondrion 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TOMM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 12198123
GO:0005742 mitochondrial outer membrane translocase complex IDA 12198123
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TOMM7: view

Pathways for TOMM7 Gene

genes like me logo Genes that share pathways with TOMM7: view

Pathways by source for TOMM7 Gene

2 Reactome pathways for TOMM7 Gene

Gene Ontology (GO) - Biological Process for TOMM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS 15644312
GO:0030150 protein import into mitochondrial matrix IEA --
GO:0044267 cellular protein metabolic process TAS --
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
genes like me logo Genes that share ontologies with TOMM7: view

Transcripts for TOMM7 Gene

Unigene Clusters for TOMM7 Gene

Translocase of outer mitochondrial membrane 7 homolog (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TOMM7 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1: - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for TOMM7 Gene

GeneLoc Exon Structure for
TOMM7
ECgene alternative splicing isoforms for
TOMM7

Expression for TOMM7 Gene

mRNA expression in normal human tissues for TOMM7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TOMM7 Gene

SOURCE GeneReport for Unigene cluster for TOMM7 Gene Hs.112318

genes like me logo Genes that share expressions with TOMM7: view

Orthologs for TOMM7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TOMM7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOMM7 36
  • 98.79 (n)
  • 98.18 (a)
TOMM7 37
  • 41 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TOMM7 36
  • 92.12 (n)
  • 98.18 (a)
TOMM7 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TOMM7 36
  • 90.3 (n)
  • 98.18 (a)
TOMM7 37
  • 45 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tomm7 36
  • 90.3 (n)
  • 94.55 (a)
Tomm7 16
Tomm7 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TOMM7 37
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TOMM7 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tomm7 36
  • 89.7 (n)
  • 94.55 (a)
chicken
(Gallus gallus)
Aves TOMM7 36
  • 80.61 (n)
  • 87.27 (a)
lizard
(Anolis carolinensis)
Reptilia TOMM7 37
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25377 36
zebrafish
(Danio rerio)
Actinopterygii tomm7 37
  • 82 (a)
OneToOne
Species with no ortholog for TOMM7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TOMM7 Gene

ENSEMBL:
Gene Tree for TOMM7 (if available)
TreeFam:
Gene Tree for TOMM7 (if available)

Paralogs for TOMM7 Gene

Selected SIMAP similar genes for TOMM7 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for TOMM7 Gene

genes like me logo Genes that share paralogs with TOMM7: view

No data available for Paralogs for TOMM7 Gene

Variants for TOMM7 Gene

Sequence variations from dbSNP and Humsavar for TOMM7 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs981792 -- 22,822,020(-) TTGGG(G/T)ttttt intron-variant
rs981793 -- 22,821,933(-) aacct(C/T)cccct intron-variant
rs1054471 -- 22,813,024(-) GTGGA(A/T)CTTGT utr-variant-3-prime
rs1474349 -- 22,814,146(+) CCTGG(A/G)AAACA intron-variant
rs2240726 -- 22,813,516(-) ATCTA(A/G)TAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TOMM7 Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
dgv2070e1 CNV Complex 17122850
nsv526131 CNV Loss 19592680
esv2467344 CNV Insertion 19546169
esv269276 CNV Insertion 20981092
esv272529 CNV Insertion 20981092

Relevant External Links for TOMM7 Gene

HapMap Linkage Disequilibrium report
TOMM7

Disorders for TOMM7 Gene

Relevant External Links for TOMM7

Genetic Association Database (GAD)
TOMM7
Human Genome Epidemiology (HuGE) Navigator
TOMM7
genes like me logo Genes that share disorders with TOMM7: view

No data available for UniProtKB/Swiss-Prot for TOMM7 Gene

Publications for TOMM7 Gene

  1. Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. (PMID: 18331822) Kato H. … Mihara K. (Biochem. Biophys. Res. Commun. 2008) 3 4 23
  2. Cloning and characterization of the human novel gene encoding 6.2 kDa protein highly expressed upon ultraviolet irradiation in DNA-PK- deleted human glioma M059J cells. (PMID: 10647823) Lee J.-S. (DNA Seq. 1999) 2 3 4
  3. Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane. (PMID: 12198123) Johnston A.J. … Ryan M.T. (J. Biol. Chem. 2002) 2 3 4
  4. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  5. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson S.A. … Youle R.J. (Nature 2013) 3 4

Products for TOMM7 Gene

Sources for TOMM7 Gene

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