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Aliases for TOMM7 Gene

Aliases for TOMM7 Gene

  • Translocase Of Outer Mitochondrial Membrane 7 2 3 5
  • Translocase Of Outer Membrane 7 KDa Subunit Homolog 3 4
  • TOM7 3 4
  • Translocase Of Outer Mitochondrial Membrane 7 Homolog (Yeast) 2
  • Translocase Of Outer Mitochondrial Membrane 7 Homolog 3
  • Mitochondrial Import Receptor Subunit TOM7 Homolog 3
  • 6.2 Kd Protein 3
  • TOMM07 4

External Ids for TOMM7 Gene

Previous GeneCards Identifiers for TOMM7 Gene

  • GC07M022560
  • GC07M022594
  • GC07M022626
  • GC07M022818
  • GC07M022735

Summaries for TOMM7 Gene

Entrez Gene Summary for TOMM7 Gene

  • This gene encodes a subunit of the translocase of the outer mitochondrial membrane. The encoded protein regulates the assembly and stability of the translocase complex. [provided by RefSeq, Oct 2012]

GeneCards Summary for TOMM7 Gene

TOMM7 (Translocase Of Outer Mitochondrial Membrane 7) is a Protein Coding gene. Among its related pathways are Pink/Parkin Mediated Mitophagy and Mitochondrial protein import. GO annotations related to this gene include protein transmembrane transporter activity.

UniProtKB/Swiss-Prot for TOMM7 Gene

  • Required for assembly and stability of the TOM complex. Positive regulator of PARK2 translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOMM7 Gene

Genomics for TOMM7 Gene

Regulatory Elements for TOMM7 Gene

Enhancers for TOMM7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F022819 0.4 ENCODE 60.3 +1.1 1073 4.1 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 TOMM7 ENSG00000228649 EEF1A1P6 TRA2A FAM126A PIR54491
GH07F022809 0.2 ENCODE 59.2 +11.7 11691 3.5 BRD4 MNT ZNF121 ZNF316 GATA2 SMARCA4 POLR2A PBX2 NFE2 EMSY TOMM7 ENSG00000228649 FAM126A PIR54491
GH07F022852 1.3 FANTOM5 Ensembl ENCODE 34.5 -34.4 -34447 9.8 PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 CBX5 ZNF143 TOMM7 ENSG00000228649 FAM126A LOC541472 IL6 ENSG00000226329 STEAP1B SNORD93
GH07F022841 1.1 Ensembl ENCODE 19.8 -20.1 -20061 2.8 STAT1 PKNOX1 NR2F1 POLR2A SMARCA4 PBX2 NR2F6 NR2C2 TOMM7 ENSG00000228649 FAM126A GC07P022837 GC07P022853
GH07F022786 0.2 ENCODE 18.8 +36.2 36185 0.9 ELF3 PKNOX1 ATF1 MLX ARID4B BMI1 DMAP1 THRB RAD21 RARA TOMM7 GC07M022788 RPS26P32
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TOMM7 on UCSC Golden Path with GeneCards custom track

Promoters for TOMM7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000309143 652 2801 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143

Genomic Location for TOMM7 Gene

Chromosome:
7
Start:
22,812,628 bp from pter
End:
22,822,852 bp from pter
Size:
10,225 bases
Orientation:
Minus strand

Genomic View for TOMM7 Gene

Genes around TOMM7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOMM7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOMM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOMM7 Gene

Proteins for TOMM7 Gene

  • Protein details for TOMM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0U1-TOM7_HUMAN
    Recommended name:
    Mitochondrial import receptor subunit TOM7 homolog
    Protein Accession:
    Q9P0U1
    Secondary Accessions:
    • O95939

    Protein attributes for TOMM7 Gene

    Size:
    55 amino acids
    Molecular mass:
    6248 Da
    Quaternary structure:
    • Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).

neXtProt entry for TOMM7 Gene

Post-translational modifications for TOMM7 Gene

  • Ubiquitination at Lys 17
  • Modification sites at PhosphoSitePlus

Other Protein References for TOMM7 Gene

No data available for DME Specific Peptides for TOMM7 Gene

Domains & Families for TOMM7 Gene

Protein Domains for TOMM7 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9P0U1

UniProtKB/Swiss-Prot:

TOM7_HUMAN :
  • Belongs to the Tom7 family.
Family:
  • Belongs to the Tom7 family.
genes like me logo Genes that share domains with TOMM7: view

Function for TOMM7 Gene

Molecular function for TOMM7 Gene

UniProtKB/Swiss-Prot Function:
Required for assembly and stability of the TOM complex. Positive regulator of PARK2 translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria.

Gene Ontology (GO) - Molecular Function for TOMM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12198123
GO:0008320 protein transmembrane transporter activity TAS 15644312
GO:0015266 contributes_to protein channel activity IBA --
genes like me logo Genes that share ontologies with TOMM7: view

Phenotypes for TOMM7 Gene

GenomeRNAi human phenotypes for TOMM7:
genes like me logo Genes that share phenotypes with TOMM7: view

Animal Model Products

miRNA for TOMM7 Gene

miRTarBase miRNAs that target TOMM7

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TOMM7 Gene

Localization for TOMM7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOMM7 Gene

Mitochondrion outer membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TOMM7 Gene COMPARTMENTS Subcellular localization image for TOMM7 gene
Compartment Confidence
mitochondrion 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TOMM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 12198123
GO:0005741 mitochondrial outer membrane TAS --
GO:0005742 mitochondrial outer membrane translocase complex IEA,TAS 24270810
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TOMM7: view

Pathways & Interactions for TOMM7 Gene

genes like me logo Genes that share pathways with TOMM7: view

Pathways by source for TOMM7 Gene

Gene Ontology (GO) - Biological Process for TOMM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS 15644312
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0016236 macroautophagy TAS --
GO:0030150 protein import into mitochondrial matrix IEA,IBA --
genes like me logo Genes that share ontologies with TOMM7: view

No data available for SIGNOR curated interactions for TOMM7 Gene

Transcripts for TOMM7 Gene

Unigene Clusters for TOMM7 Gene

Translocase of outer mitochondrial membrane 7 homolog (yeast):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOMM7 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1: - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for TOMM7 Gene

GeneLoc Exon Structure for
TOMM7
ECgene alternative splicing isoforms for
TOMM7

Expression for TOMM7 Gene

mRNA expression in normal human tissues for TOMM7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TOMM7 Gene

This gene is overexpressed in Pancreas (30.9) and Heart (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TOMM7 Gene



NURSA nuclear receptor signaling pathways regulating expression of TOMM7 Gene:

TOMM7

SOURCE GeneReport for Unigene cluster for TOMM7 Gene:

Hs.112318
genes like me logo Genes that share expression patterns with TOMM7: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TOMM7 Gene

Orthologs for TOMM7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TOMM7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOMM7 34 35
  • 98.79 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TOMM7 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TOMM7 34 35
  • 92.12 (n)
dog
(Canis familiaris)
Mammalia TOMM7 34 35
  • 90.3 (n)
mouse
(Mus musculus)
Mammalia Tomm7 34 16 35
  • 90.3 (n)
rat
(Rattus norvegicus)
Mammalia Tomm7 34
  • 89.7 (n)
oppossum
(Monodelphis domestica)
Mammalia TOMM7 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves TOMM7 34
  • 80.61 (n)
lizard
(Anolis carolinensis)
Reptilia TOMM7 35
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25377 34
zebrafish
(Danio rerio)
Actinopterygii tomm7 35
  • 82 (a)
OneToOne
Species where no ortholog for TOMM7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TOMM7 Gene

ENSEMBL:
Gene Tree for TOMM7 (if available)
TreeFam:
Gene Tree for TOMM7 (if available)

Paralogs for TOMM7 Gene

(1) SIMAP similar genes for TOMM7 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for TOMM7 Gene

genes like me logo Genes that share paralogs with TOMM7: view

No data available for Paralogs for TOMM7 Gene

Variants for TOMM7 Gene

Sequence variations from dbSNP and Humsavar for TOMM7 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10224273 -- 22,821,300(+) AGCTG(C/T)GCGGG intron-variant
rs10224533 -- 22,821,522(+) ggagg(G/T)agcta intron-variant
rs10238497 -- 22,815,829(+) AAAAA(A/G)AAAAA intron-variant
rs10250212 -- 22,816,781(+) AATTA(A/C)TTGGG intron-variant
rs10259561 -- 22,819,474(+) CAAGC(A/G)ATTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TOMM7 Gene

Variant ID Type Subtype PubMed ID
esv2467344 CNV insertion 19546169
esv2759518 CNV loss 17122850
nsv1027363 CNV gain 25217958
nsv1132042 CNV deletion 24896259
nsv526131 CNV loss 19592680
nsv7393 OTHER inversion 18451855

Variation tolerance for TOMM7 Gene

Residual Variation Intolerance Score: 68.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TOMM7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TOMM7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOMM7 Gene

Disorders for TOMM7 Gene

Relevant External Links for TOMM7

Genetic Association Database (GAD)
TOMM7
Human Genome Epidemiology (HuGE) Navigator
TOMM7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TOMM7

No disorders were found for TOMM7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TOMM7 Gene

Publications for TOMM7 Gene

  1. Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. (PMID: 18331822) Kato H. … Mihara K. (Biochem. Biophys. Res. Commun. 2008) 3 4 22 64
  2. Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane. (PMID: 12198123) Johnston A.J. … Ryan M.T. (J. Biol. Chem. 2002) 2 3 4 64
  3. Cloning and characterization of the human novel gene encoding 6.2 kDa protein highly expressed upon ultraviolet irradiation in DNA-PK- deleted human glioma M059J cells. (PMID: 10647823) Lee J.-S. (DNA Seq. 1999) 2 3 4 64
  4. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson S.A. … Youle R.J. (Nature 2013) 3 4 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for TOMM7 Gene

Sources for TOMM7 Gene

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