TOMM6 Gene
protein-coding GIFtS: 38
GCID: GC06P041755
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translocase of outer mitochondrial membrane 6 homolog (yeast)
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Aliases
for TOMM6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Translocase Of Outer Mitochondrial Membrane 6 Homolog (Yeast)1 2 | | Mitochondrial Import Receptor Subunit TOM6 Homolog2 | | OBTP1 2 3 | | Over-Expressed Breast Tumor Protein2 | | Overexpressed Breast Tumor Protein2 3 | | TOM63 | | Translocase Of Outer Membrane 6 KDa Subunit Homolog2 3 | | |
Export aliases for TOMM6 gene to outside databasesPrevious GC identifers: GC06P041864 GC06P041473 |
Summaries
for TOMM6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TOMM6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TOMM6 gene promoter:
E2F-4 E2F-3a C/EBPbeta E2F-5 Lmo2 E2F-2 Evi-1 MZF-1 E2F-1 E2F
Other transcription factors
Search SABiosciences Chromatin IP Primers for TOMM6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOMM6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.1 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p21.1TOMM6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P041755: view genomic region
(about GC identifiers)
Start:
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41,755,181 bp from pter |
End:
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41,757,636 bp from pter |
Size:
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2,456 bases |
Orientation:
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plus strand |
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Proteins
for TOMM6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TOM6_HUMAN, Q96B49 (See
protein sequence)Recommended Name: Mitochondrial import receptor subunit TOM6 homolog Size: 74 amino acids; 8002 Da
Subunit: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) whichconsists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70)
Subcellular location: Mitochondrion outer membrane
Secondary accessions: B2DG15 Q9UH52Explore the universe of human proteins at neXtProt for TOMM6: NX_Q96B49
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96B49
TOMM6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001127965.1
ENSEMBL proteins: ENSP00000381859 ENSP00000381856 Reactome Protein details: Q96B49
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
-- | -- | | GO:0005741 | mitochondrial outer membrane |
IEA | -- |
TOMM6 for ontologies About GeneDecksing
TOMM6 Antibody Products:
Assay Products for TOMM6: |
Protein
Domains /
Families
for TOMM6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96B49 UniProtKB/Swiss-Prot: TOM6_HUMAN, Q96B49Similarity: Belongs to the Tom6 family |
Function
for TOMM6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TOMM6 (NM_001134493) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TOMM6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM6 |
2 GenomeRNAi human phenotypes for TOMM6:
|
Pathways & Interactions
for TOMM6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Mitochondrial Protein Import | | | 2 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for TOMM6
TOMM6 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TOMM6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/25 Interacting proteins for TOMM6 (ENSP000003818564) via UniProtKB, MINT, STRING, and/or I2D (see all 25)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006626 | protein targeting to mitochondrion |
TAS | -- | | GO:0044267 | cellular protein metabolic process |
TAS | -- |
TOMM6 for ontologies About GeneDecksing
|
Drugs & Compounds
for TOMM6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TOMM6
Search CenterWatch for drugs/clinical trials and news about TOMM6 / TOM6
|
Transcripts
for TOMM6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TOMM6 gene: NM_001134493.1 Unigene Cluster for TOMM6: Translocase of outer mitochondrial membrane 6 homolog (yeast) Hs.731633 [show with all ESTs]Unigene Representative Sequence: BQ0575362 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000398884 ENST00000398881
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TOMM6 (NM_001134493) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TOMM6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM6 |
Additional cDNA sequence: AB435319.1 AF216754.1 AJ420506.1 BC015975.1 BC018624.1 BC022274.1 BC067252.1 BC107435.1 L34839.1 19 DOTS entries: DT.91683884 DT.95338066 DT.446079 DT.100827095 DT.92388410 DT.121327437 DT.121327449 DT.100827096 DT.91765233 DT.97864391 DT.102831347 DT.100827099 DT.91765226 DT.121327421 DT.121327574 DT.91765229 DT.95213540 DT.100829924 DT.95213518
GeneLoc Exon Structure
|
Expression
for TOMM6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TOMM6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCACCTCAGC
About this image
See TOMM6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TOMM6
SOURCE GeneReport for Unigene cluster: Hs.731633
SABiosciences Custom PCR Arrays for TOMM6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOMM6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TOMM6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOMM6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOMM6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM6 |
Orthologs
for TOMM6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TOMM6 gene from 2/7 species (see all 7) About this table
ENSEMBL Gene Tree for TOMM6 (if available)
TreeFam Gene Tree for TOMM6 (if available) |
Paralogs
for TOMM6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TOMM6 gene
TOMM6 for paralogs About GeneDecksing
5 Pseudogenes.org Pseudogenes for TOMM6
PGOHUM00000242540 PGOHUM00000239602 PGOHUM00000248203 PGOHUM00000246610 PGOHUM00000243438
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Genomic Variants
for TOMM6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TOMM6 (41755181 - 41757636 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TOMM6: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOMM6 |
|
Disorders
/ Diseases
for TOMM6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TOMM6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TOMM6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TOMM6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. (PubMed id 18331822)1, 2, 3 Kato H. and Mihara K. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC. (PubMed id 16097034)1 Gevaert K.... Vandekerckhove J. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Identification of genes overexpressed in tumors through preferential expression screening in trophoblasts. (PubMed id 7923143)1 Chassin D....Tournaire M. (1994)
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External Searches for TOMM6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TOMM6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TOMM6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TOMM6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TOMM6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TOMM6 gene:
Search GeneIP for patents involving TOMM6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TOMM6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TOMM6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TOMM6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOMM6 | | | OriGene Protein Over-expression Lysate for TOMM6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TOMM6 | | OriGene 3'-UTR Clone for TOMM6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TOMM6 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 |  |  |  | |
| | | | Search Tocris compounds for TOMM6 |
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 | | | TOMM6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM6 |
|  |  |  | | | | ThermoFisher Antibodies for TOMM6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM6 |
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