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Aliases for TOMM6 Gene

Aliases for TOMM6 Gene

  • Translocase Of Outer Mitochondrial Membrane 6 2 3
  • Translocase Of Outer Mitochondrial Membrane 6 Homolog (Yeast) 2 5
  • Translocase Of Outer Membrane 6 KDa Subunit Homolog 3 4
  • Over-Expressed Breast Tumor Protein 2 3
  • Overexpressed Breast Tumor Protein 3 4
  • OBTP 3 4
  • TOM6 3 4
  • Translocase Of Outer Mitochondrial Membrane 6 Homolog 3

External Ids for TOMM6 Gene

Previous GeneCards Identifiers for TOMM6 Gene

  • GC06P041864
  • GC06P041755
  • GC06P041473

Summaries for TOMM6 Gene

GeneCards Summary for TOMM6 Gene

TOMM6 (Translocase Of Outer Mitochondrial Membrane 6) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Mitochondrial protein import.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOMM6 Gene

Genomics for TOMM6 Gene

Regulatory Elements for TOMM6 Gene

Promoters for TOMM6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TOMM6 on UCSC Golden Path with GeneCards custom track

Genomic Location for TOMM6 Gene

Chromosome:
6
Start:
41,787,443 bp from pter
End:
41,789,898 bp from pter
Size:
2,456 bases
Orientation:
Plus strand

Genomic View for TOMM6 Gene

Genes around TOMM6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOMM6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOMM6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOMM6 Gene

Proteins for TOMM6 Gene

  • Protein details for TOMM6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B49-TOM6_HUMAN
    Recommended name:
    Mitochondrial import receptor subunit TOM6 homolog
    Protein Accession:
    Q96B49
    Secondary Accessions:
    • B2DG15
    • Q9UH52

    Protein attributes for TOMM6 Gene

    Size:
    74 amino acids
    Molecular mass:
    8002 Da
    Quaternary structure:
    • Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).

neXtProt entry for TOMM6 Gene

Proteomics data for TOMM6 Gene at MOPED

Post-translational modifications for TOMM6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TOMM6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TOMM6 Gene

Domains & Families for TOMM6 Gene

Protein Domains for TOMM6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TOMM6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96B49

UniProtKB/Swiss-Prot:

TOM6_HUMAN :
  • Belongs to the Tom6 family.
Family:
  • Belongs to the Tom6 family.
genes like me logo Genes that share domains with TOMM6: view

Function for TOMM6 Gene

Phenotypes for TOMM6 Gene

genes like me logo Genes that share phenotypes with TOMM6: view

Animal Model Products

CRISPR Products

miRNA for TOMM6 Gene

miRTarBase miRNAs that target TOMM6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TOMM6 Gene

Localization for TOMM6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOMM6 Gene

Mitochondrion outer membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TOMM6 Gene COMPARTMENTS Subcellular localization image for TOMM6 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TOMM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane TAS --
genes like me logo Genes that share ontologies with TOMM6: view

Pathways & Interactions for TOMM6 Gene

genes like me logo Genes that share pathways with TOMM6: view

Pathways by source for TOMM6 Gene

Interacting Proteins for TOMM6 Gene

Gene Ontology (GO) - Biological Process for TOMM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with TOMM6: view

No data available for SIGNOR curated interactions for TOMM6 Gene

Drugs & Compounds for TOMM6 Gene

No Compound Related Data Available

Transcripts for TOMM6 Gene

mRNA/cDNA for TOMM6 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TOMM6 Gene

Translocase of outer mitochondrial membrane 6 homolog (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TOMM6 Gene

No ASD Table

Relevant External Links for TOMM6 Gene

GeneLoc Exon Structure for
TOMM6
ECgene alternative splicing isoforms for
TOMM6

Expression for TOMM6 Gene

mRNA expression in normal human tissues for TOMM6 Gene

Protein differential expression in normal tissues from HIPED for TOMM6 Gene

This gene is overexpressed in Nasal epithelium (48.3) and Pancreas (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TOMM6 Gene



SOURCE GeneReport for Unigene cluster for TOMM6 Gene Hs.731633

genes like me logo Genes that share expression patterns with TOMM6: view

Protein tissue co-expression partners for TOMM6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TOMM6 Gene

Orthologs for TOMM6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TOMM6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC739793 35
  • 100 (n)
  • 100 (a)
TOMM6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 91 (a)
OneToMany
TOMM6 36
  • 93 (a)
OneToMany
TOMM6 35
  • 86.94 (n)
  • 93.24 (a)
dog
(Canis familiaris)
Mammalia TOMM6 35
  • 87.84 (n)
  • 93.24 (a)
TOMM6 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tomm6 36
  • 91 (a)
OneToOne
Tomm6 16
Tomm6 35
  • 83.33 (n)
  • 90.54 (a)
oppossum
(Monodelphis domestica)
Mammalia TOMM6 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tomm6 35
  • 86.94 (n)
  • 91.89 (a)
zebrafish
(Danio rerio)
Actinopterygii TOMM6 36
  • 60 (a)
OneToOne
Species with no ortholog for TOMM6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TOMM6 Gene

ENSEMBL:
Gene Tree for TOMM6 (if available)
TreeFam:
Gene Tree for TOMM6 (if available)

Paralogs for TOMM6 Gene

genes like me logo Genes that share paralogs with TOMM6: view

No data available for Paralogs for TOMM6 Gene

Variants for TOMM6 Gene

Sequence variations from dbSNP and Humsavar for TOMM6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs9471657 -- 41,789,177(+) TCGTT(A/C)ACTGT intron-variant
rs11751964 -- 41,788,144(+) CTTTT(C/T)TGTTT intron-variant
rs41273794 -- 41,787,970(+) TGCCT(C/T)ACTGA intron-variant
rs34682878 -- 41,788,056(+) ATCAA(-/G)GGGAA intron-variant
rs56956965 -- 41,788,145(+) TTTTT(-/CT/TG)GTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TOMM6 Gene

Variant ID Type Subtype PubMed ID
nsv885833 CNV Loss 21882294

Variation tolerance for TOMM6 Gene

Gene Damage Index Score: 0.19; 4.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TOMM6 Gene

HapMap Linkage Disequilibrium report
TOMM6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOMM6 Gene

Disorders for TOMM6 Gene

Relevant External Links for TOMM6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TOMM6

No disorders were found for TOMM6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TOMM6 Gene

Publications for TOMM6 Gene

  1. Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. (PMID: 18331822) Kato H. … Mihara K. (Biochem. Biophys. Res. Commun. 2008) 2 3 4 67
  2. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3
  3. Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC. (PMID: 16097034) Gevaert K. … Vandekerckhove J. (Proteomics 2005) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for TOMM6 Gene

Sources for TOMM6 Gene

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