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Aliases for TOMM6 Gene

Aliases for TOMM6 Gene

  • Translocase Of Outer Mitochondrial Membrane 6 2 3 5
  • Translocase Of Outer Membrane 6 KDa Subunit Homolog 3 4
  • Over-Expressed Breast Tumor Protein 2 3
  • Overexpressed Breast Tumor Protein 3 4
  • OBTP 3 4
  • TOM6 3 4
  • Translocase Of Outer Mitochondrial Membrane 6 Homolog (Yeast) 2
  • Translocase Of Outer Mitochondrial Membrane 6 Homolog 3
  • Mitochondrial Import Receptor Subunit TOM6 Homolog 3

External Ids for TOMM6 Gene

Previous GeneCards Identifiers for TOMM6 Gene

  • GC06P041864
  • GC06P041755
  • GC06P041473

Summaries for TOMM6 Gene

GeneCards Summary for TOMM6 Gene

TOMM6 (Translocase Of Outer Mitochondrial Membrane 6) is a Protein Coding gene. Among its related pathways are Mitochondrial protein import and Pink/Parkin Mediated Mitophagy.

Additional gene information for TOMM6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOMM6 Gene

Genomics for TOMM6 Gene

Regulatory Elements for TOMM6 Gene

Enhancers for TOMM6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H042040 2 FANTOM5 Ensembl ENCODE dbSUPER 11 +258.9 258886 11 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D SSRP1 ENSG00000124593 CCND3 RNU6-761P ENSG00000207371 MED20 BYSL FRS3 PRICKLE4 USP49 TOMM6
GH06H042020 2 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +238.0 237954 8.8 HDGF PKNOX1 FOXA2 ARNT ZNF766 ZNF143 ZNF207 FOS REST ZNF592 ENSG00000124593 MED20 CCND3 TAF8 USP49 PRICKLE4 FRS3 ENSG00000207371 BYSL TOMM6
GH06H041934 1.8 FANTOM5 ENCODE dbSUPER 10.7 +151.3 151263 8.9 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ENSG00000124593 MED20 USP49 FRS3 ENSG00000207371 BYSL RNU6-761P RPL7L1 PRICKLE4 TOMM6
GH06H042029 1.5 Ensembl ENCODE dbSUPER 10.7 +243.4 243409 2 HDGF ATF1 ARNT TCF12 ZNF766 GATA2 FOS ATF7 NCOA1 ZNF592 ENSG00000124593 USP49 FRS3 PRICKLE4 TOMM6 MED20 ENSG00000207371 BYSL ENSG00000206977 ENSG00000214732
GH06H042038 1.4 Ensembl ENCODE dbSUPER 11 +251.7 251695 2.1 HDAC1 HDGF TBL1XR1 SIN3A ZNF766 ELK1 EGR1 ZNF143 ATF7 RUNX3 ENSG00000124593 RNU6-761P MED20 ENSG00000207371 BYSL PRICKLE4 FRS3 USP49 TOMM6 ENSG00000206977
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TOMM6 on UCSC Golden Path with GeneCards custom track

Promoters for TOMM6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for TOMM6 Gene

Genomic Locations for TOMM6 Gene
2,456 bases
Plus strand

Genomic View for TOMM6 Gene

Genes around TOMM6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOMM6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOMM6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOMM6 Gene

Proteins for TOMM6 Gene

  • Protein details for TOMM6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial import receptor subunit TOM6 homolog
    Protein Accession:
    Secondary Accessions:
    • B2DG15
    • Q9UH52

    Protein attributes for TOMM6 Gene

    74 amino acids
    Molecular mass:
    8002 Da
    Quaternary structure:
    • Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).

neXtProt entry for TOMM6 Gene

Post-translational modifications for TOMM6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TOMM6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TOMM6 Gene

Domains & Families for TOMM6 Gene

Gene Families for TOMM6 Gene

Protein Domains for TOMM6 Gene


Suggested Antigen Peptide Sequences for TOMM6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Tom6 family.
  • Belongs to the Tom6 family.
genes like me logo Genes that share domains with TOMM6: view

Function for TOMM6 Gene

Phenotypes From GWAS Catalog for TOMM6 Gene

Phenotypes for TOMM6 Gene

genes like me logo Genes that share phenotypes with TOMM6: view

miRNA for TOMM6 Gene

miRTarBase miRNAs that target TOMM6

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TOMM6 Gene

Localization for TOMM6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOMM6 Gene

Mitochondrion outer membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TOMM6 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TOMM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005741 mitochondrial outer membrane TAS --
GO:0005742 mitochondrial outer membrane translocase complex IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TOMM6: view

Pathways & Interactions for TOMM6 Gene

genes like me logo Genes that share pathways with TOMM6: view

Pathways by source for TOMM6 Gene

Gene Ontology (GO) - Biological Process for TOMM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0016236 macroautophagy TAS --
genes like me logo Genes that share ontologies with TOMM6: view

No data available for SIGNOR curated interactions for TOMM6 Gene

Drugs & Compounds for TOMM6 Gene

No Compound Related Data Available

Transcripts for TOMM6 Gene

mRNA/cDNA for TOMM6 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TOMM6 Gene

Translocase of outer mitochondrial membrane 6 homolog (yeast):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOMM6 Gene

No ASD Table

Relevant External Links for TOMM6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TOMM6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TOMM6 Gene

Protein differential expression in normal tissues from HIPED for TOMM6 Gene

This gene is overexpressed in Nasal epithelium (48.3) and Pancreas (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TOMM6 Gene

Protein tissue co-expression partners for TOMM6 Gene

NURSA nuclear receptor signaling pathways regulating expression of TOMM6 Gene:


SOURCE GeneReport for Unigene cluster for TOMM6 Gene:


Evidence on tissue expression from TISSUES for TOMM6 Gene

  • Nervous system(4.5)
  • Bone marrow(4.4)
  • Skin(4.4)
  • Adrenal gland(2.1)
  • Lymph node(2.1)
  • Heart(2)
  • Kidney(2)
  • Muscle(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with TOMM6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TOMM6 Gene

Orthologs for TOMM6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TOMM6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC739793 33
  • 100 (n)
TOMM6 34
  • 100 (a)
(Bos Taurus)
Mammalia -- 34
  • 91 (a)
TOMM6 33 34
  • 86.94 (n)
(Canis familiaris)
Mammalia TOMM6 33 34
  • 87.84 (n)
(Rattus norvegicus)
Mammalia Tomm6 33
  • 86.94 (n)
(Mus musculus)
Mammalia Tomm6 33 16 34
  • 83.33 (n)
(Monodelphis domestica)
Mammalia TOMM6 34
  • 61 (a)
(Danio rerio)
Actinopterygii TOMM6 34
  • 60 (a)
Species where no ortholog for TOMM6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TOMM6 Gene

Gene Tree for TOMM6 (if available)
Gene Tree for TOMM6 (if available)

Paralogs for TOMM6 Gene

genes like me logo Genes that share paralogs with TOMM6: view

No data available for Paralogs for TOMM6 Gene

Variants for TOMM6 Gene

Sequence variations from dbSNP and Humsavar for TOMM6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000565706 -- 41,787,689(+) CGAAG(C/T)TTTCC downstream-variant-500B, utr-variant-5-prime
rs1002066436 -- 41,786,702(+) CTAGC(C/T)GCGGT intron-variant, upstream-variant-2KB
rs1002401169 -- 41,787,387(+) TCCAC(A/C)GGCTG downstream-variant-500B, upstream-variant-2KB
rs1003020767 -- 41,790,184(+) TAGTG(C/T)ACCAG downstream-variant-500B, utr-variant-3-prime
rs1003081403 -- 41,789,722(+) GTCCA(C/T)GCAGA intron-variant, utr-variant-3-prime

Variation tolerance for TOMM6 Gene

Gene Damage Index Score: 0.19; 4.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TOMM6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TOMM6 Gene

Disorders for TOMM6 Gene

Relevant External Links for TOMM6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TOMM6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TOMM6 Gene

Publications for TOMM6 Gene

  1. Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. (PMID: 18331822) Kato H … Mihara K (Biochemical and biophysical research communications 2008) 2 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60
  4. A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells. (PMID: 26272612) Dai FF … Wheeler MB (The Journal of biological chemistry 2015) 3 60
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome AS … Carapito C (Proteomics 2015) 4 60

Products for TOMM6 Gene

Sources for TOMM6 Gene

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