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Aliases for TOMM6 Gene

Aliases for TOMM6 Gene

  • Translocase Of Outer Mitochondrial Membrane 6 Homolog (Yeast) 2 3
  • Translocase Of Outer Membrane 6 KDa Subunit Homolog 3 4
  • Over-Expressed Breast Tumor Protein 2 3
  • Overexpressed Breast Tumor Protein 3 4
  • OBTP 3 4
  • TOM6 3 4
  • Mitochondrial Import Receptor Subunit TOM6 Homolog 3

External Ids for TOMM6 Gene

Previous GeneCards Identifiers for TOMM6 Gene

  • GC06P041864
  • GC06P041473

Summaries for TOMM6 Gene

GeneCards Summary for TOMM6 Gene

TOMM6 (Translocase Of Outer Mitochondrial Membrane 6 Homolog (Yeast)) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Mitochondrial Protein Import.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOMM6 Gene

Genomics for TOMM6 Gene

Regulatory Elements for TOMM6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TOMM6 Gene

Start:
41,787,443 bp from pter
End:
41,789,898 bp from pter
Size:
2,456 bases
Orientation:
Plus strand

Genomic View for TOMM6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TOMM6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOMM6 Gene

Proteins for TOMM6 Gene

  • Protein details for TOMM6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B49-TOM6_HUMAN
    Recommended name:
    Mitochondrial import receptor subunit TOM6 homolog
    Protein Accession:
    Q96B49
    Secondary Accessions:
    • B2DG15
    • Q9UH52

    Protein attributes for TOMM6 Gene

    Size:
    74 amino acids
    Molecular mass:
    8002 Da
    Quaternary structure:
    • Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).

neXtProt entry for TOMM6 Gene

Proteomics data for TOMM6 Gene at MOPED

Post-translational modifications for TOMM6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TOMM6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TOMM6 Gene

Domains for TOMM6 Gene

Protein Domains for TOMM6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TOMM6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96B49

UniProtKB/Swiss-Prot:

TOM6_HUMAN :
  • Q96B49
Family:
  • Belongs to the Tom6 family.
genes like me logo Genes that share domains with TOMM6: view

No data available for Gene Families for TOMM6 Gene

Function for TOMM6 Gene

Phenotypes for TOMM6 Gene

genes like me logo Genes that share phenotypes with TOMM6: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TOMM6 Gene

Localization for TOMM6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOMM6 Gene

Mitochondrion outer membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TOMM6 Gene COMPARTMENTS Subcellular localization image for TOMM6 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TOMM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005742 mitochondrial outer membrane translocase complex IEA --
genes like me logo Genes that share ontologies with TOMM6: view

Pathways for TOMM6 Gene

genes like me logo Genes that share pathways with TOMM6: view

Pathways by source for TOMM6 Gene

2 Reactome pathways for TOMM6 Gene

Interacting Proteins for TOMM6 Gene

Gene Ontology (GO) - Biological Process for TOMM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with TOMM6: view

Transcripts for TOMM6 Gene

mRNA/cDNA for TOMM6 Gene

(9) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TOMM6 Gene

Translocase of outer mitochondrial membrane 6 homolog (yeast):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TOMM6

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TOMM6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOMM6 Gene

No ASD Table

Relevant External Links for TOMM6 Gene

GeneLoc Exon Structure for
TOMM6
ECgene alternative splicing isoforms for
TOMM6

Expression for TOMM6 Gene

mRNA expression in normal human tissues for TOMM6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TOMM6 Gene

SOURCE GeneReport for Unigene cluster for TOMM6 Gene Hs.731633

genes like me logo Genes that share expressions with TOMM6: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TOMM6 Gene

Orthologs for TOMM6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TOMM6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC739793 35
  • 100 (n)
  • 100 (a)
TOMM6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 91 (a)
OneToMany
TOMM6 35
  • 86.94 (n)
  • 93.24 (a)
TOMM6 36
  • 93 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TOMM6 35
  • 87.84 (n)
  • 93.24 (a)
TOMM6 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tomm6 35
  • 83.33 (n)
  • 90.54 (a)
Tomm6 16
Tomm6 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TOMM6 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tomm6 35
  • 86.94 (n)
  • 91.89 (a)
zebrafish
(Danio rerio)
Actinopterygii TOMM6 36
  • 60 (a)
OneToOne
Species with no ortholog for TOMM6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TOMM6 Gene

ENSEMBL:
Gene Tree for TOMM6 (if available)
TreeFam:
Gene Tree for TOMM6 (if available)

Paralogs for TOMM6 Gene

genes like me logo Genes that share paralogs with TOMM6: view

No data available for Paralogs for TOMM6 Gene

Variants for TOMM6 Gene

Sequence variations from dbSNP and Humsavar for TOMM6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs9471654 -- 41,788,146(+) ttttt(C/G)ttttt intron-variant
rs9471655 -- 41,788,148(+) tttgt(G/T)ttttt intron-variant
rs9471656 -- 41,788,890(+) acagg(C/G)gcgca intron-variant
rs9471657 -- 41,789,177(+) TCGTT(A/C)ACTGT intron-variant
rs11751964 -- 41,788,144(+) CTTTT(C/T)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TOMM6 Gene

Variant ID Type Subtype PubMed ID
nsv885833 CNV Loss 21882294

Relevant External Links for TOMM6 Gene

HapMap Linkage Disequilibrium report
TOMM6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOMM6 Gene

Disorders for TOMM6 Gene

No disorders were found for TOMM6 Gene.

No data available for UniProtKB/Swiss-Prot for TOMM6 Gene

Publications for TOMM6 Gene

  1. Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. (PMID: 18331822) Kato H. … Mihara K. (Biochem. Biophys. Res. Commun. 2008) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Identification of genes overexpressed in tumors through preferential expression screening in trophoblasts. (PMID: 7923143) Chassin D. … Tournaire M. (Cancer Res. 1994) 3

Products for TOMM6 Gene

Sources for TOMM6 Gene

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