Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TOMM6 Gene

Aliases for TOMM6 Gene

  • Translocase Of Outer Mitochondrial Membrane 6 2 3 5
  • Translocase Of Outer Membrane 6 KDa Subunit Homolog 3 4
  • Over-Expressed Breast Tumor Protein 2 3
  • Overexpressed Breast Tumor Protein 3 4
  • OBTP 3 4
  • TOM6 3 4
  • Translocase Of Outer Mitochondrial Membrane 6 Homolog (Yeast) 2
  • Translocase Of Outer Mitochondrial Membrane 6 Homolog 3
  • Mitochondrial Import Receptor Subunit TOM6 Homolog 3

External Ids for TOMM6 Gene

Previous GeneCards Identifiers for TOMM6 Gene

  • GC06P041864
  • GC06P041755
  • GC06P041473

Summaries for TOMM6 Gene

GeneCards Summary for TOMM6 Gene

TOMM6 (Translocase Of Outer Mitochondrial Membrane 6) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Mitophagy.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOMM6 Gene

Genomics for TOMM6 Gene

Regulatory Elements for TOMM6 Gene

Enhancers for TOMM6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TOMM6 on UCSC Golden Path with GeneCards custom track

Promoters for TOMM6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TOMM6 Gene

41,787,443 bp from pter
41,789,898 bp from pter
2,456 bases
Plus strand

Genomic View for TOMM6 Gene

Genes around TOMM6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOMM6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOMM6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOMM6 Gene

Proteins for TOMM6 Gene

  • Protein details for TOMM6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial import receptor subunit TOM6 homolog
    Protein Accession:
    Secondary Accessions:
    • B2DG15
    • Q9UH52

    Protein attributes for TOMM6 Gene

    74 amino acids
    Molecular mass:
    8002 Da
    Quaternary structure:
    • Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).

neXtProt entry for TOMM6 Gene

Post-translational modifications for TOMM6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TOMM6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TOMM6 Gene

Domains & Families for TOMM6 Gene

Protein Domains for TOMM6 Gene


Suggested Antigen Peptide Sequences for TOMM6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Tom6 family.
  • Belongs to the Tom6 family.
genes like me logo Genes that share domains with TOMM6: view

Function for TOMM6 Gene

Phenotypes for TOMM6 Gene

genes like me logo Genes that share phenotypes with TOMM6: view

Animal Model Products

CRISPR Products

miRNA for TOMM6 Gene

miRTarBase miRNAs that target TOMM6

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TOMM6 Gene

Localization for TOMM6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOMM6 Gene

Mitochondrion outer membrane.

Subcellular locations from

Jensen Localization Image for TOMM6 Gene COMPARTMENTS Subcellular localization image for TOMM6 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TOMM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005741 mitochondrial outer membrane TAS --
GO:0005742 mitochondrial outer membrane translocase complex IEA --
genes like me logo Genes that share ontologies with TOMM6: view

Pathways & Interactions for TOMM6 Gene

genes like me logo Genes that share pathways with TOMM6: view

Pathways by source for TOMM6 Gene

Interacting Proteins for TOMM6 Gene

Gene Ontology (GO) - Biological Process for TOMM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0016236 macroautophagy TAS --
genes like me logo Genes that share ontologies with TOMM6: view

No data available for SIGNOR curated interactions for TOMM6 Gene

Drugs & Compounds for TOMM6 Gene

No Compound Related Data Available

Transcripts for TOMM6 Gene

mRNA/cDNA for TOMM6 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TOMM6 Gene

Translocase of outer mitochondrial membrane 6 homolog (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOMM6 Gene

No ASD Table

Relevant External Links for TOMM6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TOMM6 Gene

mRNA expression in normal human tissues for TOMM6 Gene

Protein differential expression in normal tissues from HIPED for TOMM6 Gene

This gene is overexpressed in Nasal epithelium (48.3) and Pancreas (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TOMM6 Gene

Protein tissue co-expression partners for TOMM6 Gene

NURSA nuclear receptor signaling pathways regulating expression of TOMM6 Gene:


SOURCE GeneReport for Unigene cluster for TOMM6 Gene:

genes like me logo Genes that share expression patterns with TOMM6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TOMM6 Gene

Orthologs for TOMM6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TOMM6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TOMM6 34
  • 86.94 (n)
  • 93.24 (a)
-- 35
  • 91 (a)
TOMM6 35
  • 93 (a)
(Canis familiaris)
Mammalia TOMM6 34
  • 87.84 (n)
  • 93.24 (a)
TOMM6 35
  • 93 (a)
(Mus musculus)
Mammalia Tomm6 34
  • 83.33 (n)
  • 90.54 (a)
Tomm6 16
Tomm6 35
  • 91 (a)
(Pan troglodytes)
Mammalia LOC739793 34
  • 100 (n)
  • 100 (a)
TOMM6 35
  • 100 (a)
(Rattus norvegicus)
Mammalia Tomm6 34
  • 86.94 (n)
  • 91.89 (a)
(Monodelphis domestica)
Mammalia TOMM6 35
  • 61 (a)
(Danio rerio)
Actinopterygii TOMM6 35
  • 60 (a)
Species where no ortholog for TOMM6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TOMM6 Gene

Gene Tree for TOMM6 (if available)
Gene Tree for TOMM6 (if available)

Paralogs for TOMM6 Gene

genes like me logo Genes that share paralogs with TOMM6: view

No data available for Paralogs for TOMM6 Gene

Variants for TOMM6 Gene

Sequence variations from dbSNP and Humsavar for TOMM6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs70987535 -- 41,788,470(-) GTCTC(-/A)AAAAA intron-variant
rs11751964 -- 41,788,144(+) CTTTT(C/T)TGTTT intron-variant
rs75125977 -- 41,788,471(+) TTTTT(G/T)AGACG intron-variant
rs9471654 -- 41,788,146(+) ttttt(C/G)ttttt intron-variant
rs9471655 -- 41,788,148(+) tttgt(G/T)ttttt intron-variant

Variation tolerance for TOMM6 Gene

Gene Damage Index Score: 0.19; 4.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TOMM6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TOMM6 Gene

Disorders for TOMM6 Gene

Relevant External Links for TOMM6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TOMM6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TOMM6 Gene

Publications for TOMM6 Gene

  1. Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. (PMID: 18331822) Kato H. … Mihara K. (Biochem. Biophys. Res. Commun. 2008) 2 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 65
  4. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 65
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 65

Products for TOMM6 Gene

Sources for TOMM6 Gene

Loading form....