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Aliases for TOMM5 Gene

Aliases for TOMM5 Gene

  • Translocase Of Outer Mitochondrial Membrane 5 Homolog (Yeast) 2 3
  • C9orf105 3 4
  • Tom5 3 4
  • Mitochondrial Import Receptor Subunit TOM5 Homolog 3
  • Mitochondrial Outer Membrane Protein TOM5 3
  • Chromosome 9 Open Reading Frame 105 2
  • BA613M10.3 3

External Ids for TOMM5 Gene

Previous Symbols for TOMM5 Gene

  • C9orf105

Summaries for TOMM5 Gene

GeneCards Summary for TOMM5 Gene

TOMM5 (Translocase Of Outer Mitochondrial Membrane 5 Homolog (Yeast)) is a Protein Coding gene. Diseases associated with TOMM5 include bronchiolitis obliterans organizing pneumonia and cryptogenic organizing pneumonia. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Mitochondrial Protein Import. GO annotations related to this gene include protein transporter activity. An important paralog of this gene is ENSG00000256966.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOMM5 Gene

Genomics for TOMM5 Gene

Genomic Location for TOMM5 Gene

Start:
37,582,646 bp from pter
End:
37,592,642 bp from pter
Size:
9,997 bases
Orientation:
Minus strand

Genomic View for TOMM5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TOMM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOMM5 Gene

Regulatory Elements for TOMM5 Gene

Proteins for TOMM5 Gene

  • Protein details for TOMM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4H5-TOM5_HUMAN
    Recommended name:
    Mitochondrial import receptor subunit TOM5 homolog
    Protein Accession:
    Q8N4H5
    Secondary Accessions:
    • B2DG07
    • F6S928
    • Q5JRT7

    Protein attributes for TOMM5 Gene

    Size:
    51 amino acids
    Molecular mass:
    6035 Da
    Quaternary structure:
    • Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).

    Alternative splice isoforms for TOMM5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TOMM5 Gene

Proteomics data for TOMM5 Gene at MOPED

Post-translational modifications for TOMM5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys10

Other Protein References for TOMM5 Gene

No data available for DME Specific Peptides for TOMM5 Gene

Domains for TOMM5 Gene

Protein Domains for TOMM5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TOMM5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N4H5

UniProtKB/Swiss-Prot:

TOM5_HUMAN
Family:
  • Belongs to the Tom5 family.:
    • Q8N4H5
genes like me logo Genes that share domains with TOMM5: view

No data available for Gene Families for TOMM5 Gene

Function for TOMM5 Gene

Gene Ontology (GO) - Molecular Function for TOMM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008565 contributes_to protein transporter activity IC 18331822
genes like me logo Genes that share ontologies with TOMM5: view
genes like me logo Genes that share phenotypes with TOMM5: view

miRNA for TOMM5 Gene

miRTarBase miRNAs that target TOMM5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TOMM5 Gene

Localization for TOMM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOMM5 Gene

Mitochondrion outer membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TOMM5 Gene COMPARTMENTS Subcellular localization image for TOMM5 gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for TOMM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005742 mitochondrial outer membrane translocase complex IDA 18331822
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TOMM5: view

Pathways for TOMM5 Gene

genes like me logo Genes that share pathways with TOMM5: view

Pathways by source for TOMM5 Gene

2 Reactome pathways for TOMM5 Gene

Interacting Proteins for TOMM5 Gene

Gene Ontology (GO) - Biological Process for TOMM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with TOMM5: view

Transcripts for TOMM5 Gene

mRNA/cDNA for TOMM5 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TOMM5 Gene

Translocase of outer mitochondrial membrane 5 homolog (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TOMM5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b
SP1: - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - -
SP5: -
SP6:

Relevant External Links for TOMM5 Gene

GeneLoc Exon Structure for
TOMM5
ECgene alternative splicing isoforms for
TOMM5

Expression for TOMM5 Gene

mRNA expression in normal human tissues for TOMM5 Gene

mRNA differential expression in normal tissues according to GTEx for TOMM5 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (4.9) and Brain - Cerebellum (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TOMM5 Gene

SOURCE GeneReport for Unigene cluster for TOMM5 Gene Hs.130774

genes like me logo Genes that share expressions with TOMM5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TOMM5 Gene

Orthologs for TOMM5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TOMM5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOMM5 35
  • 99.22 (n)
  • 98.82 (a)
TOMM5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TOMM5 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tomm5 16
Tomm5 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 65 (a)
OneToMany
Species with no ortholog for TOMM5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TOMM5 Gene

ENSEMBL:
Gene Tree for TOMM5 (if available)
TreeFam:
Gene Tree for TOMM5 (if available)

Paralogs for TOMM5 Gene

Paralogs for TOMM5 Gene

Pseudogenes.org Pseudogenes for TOMM5 Gene

genes like me logo Genes that share paralogs with TOMM5: view

Variants for TOMM5 Gene

Sequence variations from dbSNP and Humsavar for TOMM5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs3802416 -- 37,592,610(-) GAGGA(C/T)AGGCC utr-variant-5-prime
rs4271055 -- 37,592,815(+) GCTTA(C/T)AATCC upstream-variant-2KB
rs6476646 -- 37,593,419(+) GGTGA(C/T)TAGTA upstream-variant-2KB
rs7021977 -- 37,592,455(+) ATGGA(A/G)GAGAT reference, synonymous-codon
rs7042896 -- 37,593,747(+) CCTGA(C/T)CTCAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TOMM5 Gene

Variant ID Type Subtype PubMed ID
nsv893060 CNV Gain 21882294

Relevant External Links for TOMM5 Gene

HapMap Linkage Disequilibrium report
TOMM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOMM5 Gene

Disorders for TOMM5 Gene

genes like me logo Genes that share disorders with TOMM5: view

No data available for UniProtKB/Swiss-Prot for TOMM5 Gene

Publications for TOMM5 Gene

  1. Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. (PMID: 18331822) Kato H. … Mihara K. (Biochem. Biophys. Res. Commun. 2008) 2 3 4
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for TOMM5 Gene

Sources for TOMM5 Gene

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