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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TOMM5 Gene

protein-coding   GIFtS: 41
GCID: GC09M037582

translocase of outer mitochondrial membrane 5 homolog (yeast)

(Previous name: chromosome 9 open reading frame 105 )
(Previous symbol: C9orf105)
 Explore 1 disease affiliated with
TOMM5 via our new
 Human Malady Compendium 
Biological research products
for TOMM5
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Translocase Of Outer Mitochondrial Membrane 5 Homolog (Yeast)1 2     Tom52
C9orf1051 2 3     Mitochondrial Import Receptor Subunit TOM5 Homolog2
BA613M10.31     Mitochondrial Outer Membrane Protein TOM52
Chromosome 9 Open Reading Frame 1051     TOM53
RP11-263I4.12     

External Ids:    HGNC: 313691   Entrez Gene: 4015052   Ensembl: ENSG000001757687   UniProtKB: Q8N4H53   

Export aliases for TOMM5 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TOMM5 gene promoter:
         STAT1   AML1a   STAT1beta   LCR-F1   Evi-1   STAT1alpha   POU2F1   POU2F1a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TOMM5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOMM5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.2   Ensembl cytogenetic band:  9p13.2   HGNC cytogenetic band: 9p13.2

TOMM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOMM5 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M037582:  view genomic region     (about GC identifiers)

Start:
37,582,643 bp from pter      End:
37,592,639 bp from pter
Size:
9,997 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TOM5_HUMAN, Q8N4H5 (See protein sequence)
Recommended Name: Mitochondrial import receptor subunit TOM5 homolog  
Size: 51 amino acids; 6035 Da
Subunit: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which
consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70)
Subcellular location: Mitochondrion outer membrane; Single-pass membrane protein
Secondary accessions: B2DG07

Explore the universe of human proteins at neXtProt for TOMM5: NX_Q8N4H5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N4H5

  • TOMM5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001001790.1  NP_001127956.1  NP_001127957.1  

    ENSEMBL proteins: 
     ENSP00000438585   ENSP00000367004   ENSP00000313584   ENSP00000384411   ENSP00000438204  
    Reactome Protein details: Q8N4H5
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: TOMM5
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TOMM5

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005742mitochondrial outer membrane translocase complex IDA18331822
    GO:0016021integral to membrane IEA--


    TOMM5 for ontologies           About GeneDecksing



    TOMM5 Antibody Products: 
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    Novus Biologicals TOMM5 Antibody
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    Uscn Antibodies for TOMM5
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    Uscn ELISAs and CLIAs for TOMM5


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8N4H5

    UniProtKB/Swiss-Prot: TOM5_HUMAN, Q8N4H5
    Similarity: Belongs to the Tom5 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 2): TOMM5
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TOMM5
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate TOMM5:
    hsa-miR-4314 hsa-miR-935 hsa-miR-2116 hsa-miR-1914 hsa-miR-493
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: TOMM5
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    Clone
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    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM5

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008565contributes to protein transporter activity IC18331822


    TOMM5 for ontologies           About GeneDecksing


    Animal Models:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tomm5):
     cardiovascular system  hematopoietic system  immune system  mortality/aging  respiratory system 

    TOMM5 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Mitochondrial Protein Import
    Mitochondrial Protein Import1.00
    2Asparagine N-linked glycosylation
    Metabolism of proteins0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for TOMM5
        Mitochondrial Protein Import
    Metabolism of proteins



    TOMM5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TOMM5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/27 Interacting proteins for TOMM5 (ENSP000003844114) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHCHD4ENSP000002957674STRING: ENSP00000295767
    DNAJC19ENSP000003720054STRING: ENSP00000372005
    GFERENSP000002481144STRING: ENSP00000248114
    GRPEL1ENSP000002649544STRING: ENSP00000264954
    MTX2ENSP000002494424STRING: ENSP00000249442
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion TAS--
    GO:0044267cellular protein metabolic process TAS--


    TOMM5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TOMM5
    Search CenterWatch for drugs/clinical trials and news about TOMM5 / TOM5 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TOMM5 gene (3 alternative transcripts): 
    NM_001001790.2  NM_001134484.1  NM_001134485.1  

    Unigene Cluster for TOMM5:

    Translocase of outer mitochondrial membrane 5 homolog (yeast)
    Hs.130774  [show with all ESTs]
    Unigene Representative Sequence: CR627326
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000540941(uc004aae.4) ENST00000377773(uc011lql.2 uc004aaf.3)
    ENST00000321301(uc010mlx.3) ENST00000401811 ENST00000544379

    miRNA
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    OriGene 3'-UTR Clone (see all 2): TOMM5
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TOMM5
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate TOMM5:
    hsa-miR-4314 hsa-miR-935 hsa-miR-2116 hsa-miR-1914 hsa-miR-493
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TOMM5 (see all 4)
    OriGene shRNA RFP: TOMM5
    OriGene siRNA: TOMM5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOMM5
    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM5 (see all 5)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOMM5
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    Additional cDNA sequence: 

    AB435233.1 AK125697.1 BC029423.1 BC034247.1 CR627326.1 

    15 DOTS entries:

    DT.101980979  DT.117212  DT.100682525  DT.121192777  DT.121643500  DT.40126229  DT.97784668  DT.91924719 
    DT.97861910  DT.92434831  DT.121192635  DT.121192741  DT.121192850  DT.100037526  DT.95094501 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TOMM5 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b
    SP1:                                      -                 -     -     -               
    SP2:                          -     -     -           -     -     -     -               
    SP3:                          -     -     -                                             
    SP4:                                -     -                                             
    SP5:                                      -                                             


    ECgene alternative splicing isoforms for TOMM5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TOMM5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGAATAAAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See TOMM5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TOMM5

    SOURCE GeneReport for Unigene cluster: Hs.130774
        SABiosciences Custom PCR Arrays for TOMM5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TOMM5 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tomm55 translocase of outer mitochondrial membrane 5 homolog more   --   4 (23.72 cM) 45105208 
    chicken
    (Gallus gallus)
    Aves TOMM56
    Uncharacterized protein
    65(a)
    1 → many
    Z(74124520-74125003)


    ENSEMBL Gene Tree for TOMM5 (if available)
    TreeFam Gene Tree for TOMM5 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TOMM5 gene
    ENSG000002569662  

    TOMM5 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TOMM5
    PGOHUM00000243044 PGOHUM00000243317


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/111 NCBI SNPs in TOMM5 are shown (see all 111    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1155288641,2
    F,--37587911(+) CAGAAT/GCCTAA 3 -- int11Minor allele frequency- G:0.03WA 118
    rs1471110261,2
    --37588027(+) AATCAC/TGACCG 3 -- int10--------
    rs1481520031,2
    --37588031(+) ACGACC/TGTCAC 3 -- int10--------
    rs1144780491,2
    F,--37588032(+) CGACCG/ATCACA 3 -- int11Minor allele frequency- A:0.03WA 118
    rs780900511,2
    F,--37588105(+) TCCTGG/AGGAGA 3 -- int11Minor allele frequency- A:0.02EA 120
    rs1419332311,2
    --37588140(+) CTCAAA/CAAACT 3 -- int10--------
    rs1506495421,2
    --37588189(+) TTTGGC/TAGTAT 3 -- int10--------
    rs1875619371,2
    --37588737(+) GCTTTG/TAAGGT 3 -- ut310--------
    rs78558241,2
    C,F,A,H,--37588842(+) GGAGTC/TGAAAC 3 -- ut31 ese35Minor allele frequency- T:0.08NS EA WA 536
    rs2009345551,2
    --37588867(+) TCATAC/TCGTGC 3 -- ut310--------

    HapMap Linkage Disequilibrium report for TOMM5 (37582643 - 37592639 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TOMM5: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOMM5
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TOMM5 for disorders           About GeneDecksing

    1 disease for TOMM5:    About MalaCards
    barth syndrome

    2 diseases from the University of Copenhagen DISEASES database for TOMM5:
    Cryptogenic organizing pneumonia     Bronchiolitis obliterans organizing pneumonia

    Export disorders for TOMM5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TOMM5 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with TOMM5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. (PubMed id 18331822)1, 2, 3 Kato H. and Mihara K. (2008)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 401505 HGNC: 31369 Ensembl:ENSG00000175768 euGenes: HUgn401505 ECgene: TOMM5
    H-InvDB: TOMM5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TOMM5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TOMM5 gene:
    Search GeneIP for patents involving TOMM5

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