Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TOMM5 Gene

Aliases for TOMM5 Gene

  • Translocase Of Outer Mitochondrial Membrane 5 2 3 5
  • C9orf105 3 4
  • Tom5 3 4
  • Translocase Of Outer Mitochondrial Membrane 5 Homolog (Yeast) 2
  • Translocase Of Outer Mitochondrial Membrane 5 Homolog 3
  • Mitochondrial Import Receptor Subunit TOM5 Homolog 3
  • Mitochondrial Outer Membrane Protein TOM5 3
  • Chromosome 9 Open Reading Frame 105 2
  • BA613M10.3 3

External Ids for TOMM5 Gene

Previous HGNC Symbols for TOMM5 Gene

  • C9orf105

Summaries for TOMM5 Gene

GeneCards Summary for TOMM5 Gene

TOMM5 (Translocase Of Outer Mitochondrial Membrane 5) is a Protein Coding gene. Among its related pathways are Mitochondrial protein import and Pink/Parkin Mediated Mitophagy. GO annotations related to this gene include protein transporter activity. An important paralog of this gene is ENSG00000256966.

Additional gene information for TOMM5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOMM5 Gene

Genomics for TOMM5 Gene

Regulatory Elements for TOMM5 Gene

Enhancers for TOMM5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H037485 1.3 ENCODE dbSUPER 10.8 +105.8 105842 3 HDGF FOXA2 PKNOX1 ATF1 ARNT ARID4B SIN3A DMAP1 YY1 GLIS2 RPL21P83 POLR1E ZCCHC7 EXOSC3 ZBTB5 FBXO10 ENSG00000234160 TRMT10B TOMM5 ENSG00000256966
GH09H037593 1.1 Ensembl ENCODE 7.9 -1.9 -1940 1 CTCF SAP130 TAL1 RAD21 RFX5 YY1 ZNF664 TCF12 GATA2 NCOR1 TOMM5 FRMPD1
GH09H037590 1.1 ENCODE 7.2 +0.7 700 2 HDGF FOXA2 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZCCHC7 EXOSC3 POLR1E TOMM5 ENSG00000256966 GC09P037586
GH09H037621 0.5 ENCODE 12.6 -28.8 -28817 0 ZNF316 NFE2 MAFK ENSG00000256966 TOMM5 FBXO10 FRMPD1 GC09M037636
GH09H037667 0.5 Ensembl ENCODE 10.7 -75.6 -75579 0 TOMM5 ENSG00000256966 FBXO10 FRMPD1 RN7SKP171 GC09M037661 TRMT10B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TOMM5 on UCSC Golden Path with GeneCards custom track

Promoters for TOMM5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000234879 242 1601 HDGF FOXA2 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for TOMM5 Gene

Chromosome:
9
Start:
37,582,646 bp from pter
End:
37,592,642 bp from pter
Size:
9,997 bases
Orientation:
Minus strand

Genomic View for TOMM5 Gene

Genes around TOMM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOMM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOMM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOMM5 Gene

Proteins for TOMM5 Gene

  • Protein details for TOMM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4H5-TOM5_HUMAN
    Recommended name:
    Mitochondrial import receptor subunit TOM5 homolog
    Protein Accession:
    Q8N4H5
    Secondary Accessions:
    • B2DG07
    • F6S928
    • Q5JRT7

    Protein attributes for TOMM5 Gene

    Size:
    51 amino acids
    Molecular mass:
    6035 Da
    Quaternary structure:
    • Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).

    Alternative splice isoforms for TOMM5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TOMM5 Gene

Post-translational modifications for TOMM5 Gene

  • Ubiquitination at posLast=1010
  • Modification sites at PhosphoSitePlus

Other Protein References for TOMM5 Gene

No data available for DME Specific Peptides for TOMM5 Gene

Domains & Families for TOMM5 Gene

Gene Families for TOMM5 Gene

Protein Domains for TOMM5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TOMM5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N4H5

UniProtKB/Swiss-Prot:

TOM5_HUMAN :
  • Belongs to the Tom5 family.
Family:
  • Belongs to the Tom5 family.
genes like me logo Genes that share domains with TOMM5: view

Function for TOMM5 Gene

Gene Ontology (GO) - Molecular Function for TOMM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008565 contributes_to protein transporter activity IC 18331822
genes like me logo Genes that share ontologies with TOMM5: view

Phenotypes for TOMM5 Gene

GenomeRNAi human phenotypes for TOMM5:
genes like me logo Genes that share phenotypes with TOMM5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TOMM5

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TOMM5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TOMM5 Gene

Localization for TOMM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOMM5 Gene

Mitochondrion outer membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TOMM5 gene
Compartment Confidence
mitochondrion 5
extracellular 2
cytosol 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TOMM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005741 mitochondrial outer membrane TAS --
GO:0005742 mitochondrial outer membrane translocase complex IDA 18331822
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TOMM5: view

Pathways & Interactions for TOMM5 Gene

genes like me logo Genes that share pathways with TOMM5: view

Pathways by source for TOMM5 Gene

Interacting Proteins for TOMM5 Gene

Gene Ontology (GO) - Biological Process for TOMM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion IC 18331822
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0016236 macroautophagy TAS --
genes like me logo Genes that share ontologies with TOMM5: view

No data available for SIGNOR curated interactions for TOMM5 Gene

Drugs & Compounds for TOMM5 Gene

No Compound Related Data Available

Transcripts for TOMM5 Gene

mRNA/cDNA for TOMM5 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TOMM5 Gene

Translocase of outer mitochondrial membrane 5 homolog (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TOMM5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TOMM5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b
SP1: - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - -
SP5: -
SP6:

Relevant External Links for TOMM5 Gene

GeneLoc Exon Structure for
TOMM5
ECgene alternative splicing isoforms for
TOMM5

Expression for TOMM5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TOMM5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TOMM5 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.9) and Brain - Cerebellum (x4.3).

Protein differential expression in normal tissues from HIPED for TOMM5 Gene

This gene is overexpressed in Hair follicle (28.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TOMM5 Gene



Protein tissue co-expression partners for TOMM5 Gene

NURSA nuclear receptor signaling pathways regulating expression of TOMM5 Gene:

TOMM5

SOURCE GeneReport for Unigene cluster for TOMM5 Gene:

Hs.130774
genes like me logo Genes that share expression patterns with TOMM5: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TOMM5 Gene

Orthologs for TOMM5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TOMM5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOMM5 33 34
  • 99.22 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 86 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TOMM5 34
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tomm5 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 65 (a)
OneToMany
Species where no ortholog for TOMM5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TOMM5 Gene

ENSEMBL:
Gene Tree for TOMM5 (if available)
TreeFam:
Gene Tree for TOMM5 (if available)

Paralogs for TOMM5 Gene

Paralogs for TOMM5 Gene

Pseudogenes.org Pseudogenes for TOMM5 Gene

genes like me logo Genes that share paralogs with TOMM5: view

Variants for TOMM5 Gene

Sequence variations from dbSNP and Humsavar for TOMM5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1001020310 -- 37,590,632(+) TTATA(C/T)TTCAA intron-variant
rs1001055087 -- 37,590,039(+) AAATG(G/T)TATGC intron-variant
rs1001355089 -- 37,590,302(+) TAGGA(C/G)GATCA intron-variant
rs1001585147 -- 37,591,910(+) GAGCT(A/C)TTTCA intron-variant
rs1001649974 -- 37,591,649(+) ACTGC(A/G)CCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TOMM5 Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259

Variation tolerance for TOMM5 Gene

Residual Variation Intolerance Score: 69.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TOMM5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TOMM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOMM5 Gene

Disorders for TOMM5 Gene

Relevant External Links for TOMM5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TOMM5

No disorders were found for TOMM5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TOMM5 Gene

Publications for TOMM5 Gene

  1. Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. (PMID: 18331822) Kato H … Mihara K (Biochemical and biophysical research communications 2008) 2 3 4 60
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 60

Products for TOMM5 Gene

Sources for TOMM5 Gene

Content
Loading form....