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Aliases for TOMM5 Gene

Aliases for TOMM5 Gene

  • Translocase Of Outer Mitochondrial Membrane 5 2 3
  • Translocase Of Outer Mitochondrial Membrane 5 Homolog (Yeast) 2 5
  • C9orf105 3 4
  • Tom5 3 4
  • Translocase Of Outer Mitochondrial Membrane 5 Homolog 3
  • Mitochondrial Outer Membrane Protein TOM5 3
  • Chromosome 9 Open Reading Frame 105 2
  • BA613M10.3 3

External Ids for TOMM5 Gene

Previous HGNC Symbols for TOMM5 Gene

  • C9orf105

Summaries for TOMM5 Gene

GeneCards Summary for TOMM5 Gene

TOMM5 (Translocase Of Outer Mitochondrial Membrane 5) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Mitochondrial protein import. GO annotations related to this gene include protein transporter activity. An important paralog of this gene is ENSG00000256966.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOMM5 Gene

Genomics for TOMM5 Gene

Regulatory Elements for TOMM5 Gene

Promoters for TOMM5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TOMM5 on UCSC Golden Path with GeneCards custom track

Genomic Location for TOMM5 Gene

Chromosome:
9
Start:
37,582,646 bp from pter
End:
37,592,642 bp from pter
Size:
9,997 bases
Orientation:
Minus strand

Genomic View for TOMM5 Gene

Genes around TOMM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOMM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOMM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOMM5 Gene

Proteins for TOMM5 Gene

  • Protein details for TOMM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4H5-TOM5_HUMAN
    Recommended name:
    Mitochondrial import receptor subunit TOM5 homolog
    Protein Accession:
    Q8N4H5
    Secondary Accessions:
    • B2DG07
    • F6S928
    • Q5JRT7

    Protein attributes for TOMM5 Gene

    Size:
    51 amino acids
    Molecular mass:
    6035 Da
    Quaternary structure:
    • Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).

    Alternative splice isoforms for TOMM5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TOMM5 Gene

Proteomics data for TOMM5 Gene at MOPED

Post-translational modifications for TOMM5 Gene

  • Ubiquitination at Lys 10
  • Modification sites at PhosphoSitePlus

Other Protein References for TOMM5 Gene

No data available for DME Specific Peptides for TOMM5 Gene

Domains & Families for TOMM5 Gene

Protein Domains for TOMM5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TOMM5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N4H5

UniProtKB/Swiss-Prot:

TOM5_HUMAN :
  • Belongs to the Tom5 family.
Family:
  • Belongs to the Tom5 family.
genes like me logo Genes that share domains with TOMM5: view

Function for TOMM5 Gene

Phenotypes for TOMM5 Gene

GenomeRNAi human phenotypes for TOMM5:
genes like me logo Genes that share phenotypes with TOMM5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TOMM5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TOMM5 Gene

Localization for TOMM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOMM5 Gene

Mitochondrion outer membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TOMM5 Gene COMPARTMENTS Subcellular localization image for TOMM5 gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for TOMM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TOMM5: view

Pathways & Interactions for TOMM5 Gene

genes like me logo Genes that share pathways with TOMM5: view

Pathways by source for TOMM5 Gene

Interacting Proteins for TOMM5 Gene

Gene Ontology (GO) - Biological Process for TOMM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with TOMM5: view

No data available for SIGNOR curated interactions for TOMM5 Gene

Drugs & Compounds for TOMM5 Gene

No Compound Related Data Available

Transcripts for TOMM5 Gene

mRNA/cDNA for TOMM5 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TOMM5 Gene

Translocase of outer mitochondrial membrane 5 homolog (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TOMM5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b
SP1: - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - -
SP5: -
SP6:

Relevant External Links for TOMM5 Gene

GeneLoc Exon Structure for
TOMM5
ECgene alternative splicing isoforms for
TOMM5

Expression for TOMM5 Gene

mRNA expression in normal human tissues for TOMM5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TOMM5 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.9) and Brain - Cerebellum (x4.3).

Protein differential expression in normal tissues from HIPED for TOMM5 Gene

This gene is overexpressed in Hair follicle (28.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TOMM5 Gene



SOURCE GeneReport for Unigene cluster for TOMM5 Gene Hs.130774

genes like me logo Genes that share expression patterns with TOMM5: view

Protein tissue co-expression partners for TOMM5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TOMM5 Gene

Orthologs for TOMM5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TOMM5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOMM5 36
  • 99 (a)
OneToOne
TOMM5 35
  • 99.22 (n)
  • 98.82 (a)
cow
(Bos Taurus)
Mammalia TOMM5 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tomm5 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 65 (a)
OneToMany
Species with no ortholog for TOMM5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TOMM5 Gene

ENSEMBL:
Gene Tree for TOMM5 (if available)
TreeFam:
Gene Tree for TOMM5 (if available)

Paralogs for TOMM5 Gene

Paralogs for TOMM5 Gene

Pseudogenes.org Pseudogenes for TOMM5 Gene

genes like me logo Genes that share paralogs with TOMM5: view

Variants for TOMM5 Gene

Sequence variations from dbSNP and Humsavar for TOMM5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs4271055 -- 37,592,815(+) GCTTA(C/T)AATCC upstream-variant-2KB
rs7021977 -- 37,592,455(+) ATGGA(A/G)GAGAT reference, synonymous-codon
rs7042896 -- 37,593,747(+) CCTGA(C/T)CTCAG upstream-variant-2KB
rs10116200 -- 37,591,546(+) aatta(C/G)ccggg intron-variant
rs11311635 -- 37,593,358(+) TCAGA(-/G)GGGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TOMM5 Gene

Variant ID Type Subtype PubMed ID
nsv893060 CNV Gain 21882294

Variation tolerance for TOMM5 Gene

Residual Variation Intolerance Score: 69.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TOMM5 Gene

HapMap Linkage Disequilibrium report
TOMM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOMM5 Gene

Disorders for TOMM5 Gene

Relevant External Links for TOMM5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TOMM5

No disorders were found for TOMM5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TOMM5 Gene

Publications for TOMM5 Gene

  1. Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. (PMID: 18331822) Kato H. … Mihara K. (Biochem. Biophys. Res. Commun. 2008) 2 3 4 67
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for TOMM5 Gene

Sources for TOMM5 Gene

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