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Aliases for TOMM40L Gene

Aliases for TOMM40L Gene

  • Translocase Of Outer Mitochondrial Membrane 40 Homolog (Yeast)-Like 2 3
  • Protein TOMM40-Like 3 4
  • TOMM40B 3 4
  • Translocase Of Outer Mitochondrial Membrane 40 Homolog-Like (Yeast) 2
  • Translocase Of Outer Mitochondrial Membrane 40 Homolog-Like 3
  • Mitochondrial Import Receptor Subunit TOM40B 3

External Ids for TOMM40L Gene

Previous GeneCards Identifiers for TOMM40L Gene

  • GC01P158009
  • GC01P159462
  • GC01P161195
  • GC01P132552

Summaries for TOMM40L Gene

GeneCards Summary for TOMM40L Gene

TOMM40L (Translocase Of Outer Mitochondrial Membrane 40 Homolog (Yeast)-Like) is a Protein Coding gene. Among its related pathways are Amyotrophic lateral sclerosis (ALS). GO annotations related to this gene include porin activity. An important paralog of this gene is TOMM40.

UniProtKB/Swiss-Prot for TOMM40L Gene

  • Potential channel-forming protein implicated in import of protein precursors into mitochondria.

Gene Wiki entry for TOMM40L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOMM40L Gene

Genomics for TOMM40L Gene

Regulatory Elements for TOMM40L Gene

Genomic Location for TOMM40L Gene

Start:
161,225,939 bp from pter
End:
161,230,746 bp from pter
Size:
4,808 bases
Orientation:
Plus strand

Genomic View for TOMM40L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TOMM40L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOMM40L Gene

Proteins for TOMM40L Gene

  • Protein details for TOMM40L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969M1-TM40L_HUMAN
    Recommended name:
    Mitochondrial import receptor subunit TOM40B
    Protein Accession:
    Q969M1
    Secondary Accessions:
    • B7Z4U0
    • D3DVG9

    Protein attributes for TOMM40L Gene

    Size:
    308 amino acids
    Molecular mass:
    33917 Da
    Quaternary structure:
    • Forms part of the preprotein translocase of the outer mitochondrial membrane (TOM complex) containing TOMM22, TOMM40, TOMM40L and TOMM70. Interacts with mitochondrial targeting sequences (By similarity).

    Alternative splice isoforms for TOMM40L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TOMM40L Gene

Proteomics data for TOMM40L Gene at MOPED

Post-translational modifications for TOMM40L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TOMM40L Gene

No data available for DME Specific Peptides for TOMM40L Gene

Domains for TOMM40L Gene

Protein Domains for TOMM40L Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q969M1

UniProtKB/Swiss-Prot:

TM40L_HUMAN :
  • Q969M1
Family:
  • Belongs to the Tom40 family.
genes like me logo Genes that share domains with TOMM40L: view

No data available for Gene Families for TOMM40L Gene

Function for TOMM40L Gene

Molecular function for TOMM40L Gene

UniProtKB/Swiss-Prot Function:
Potential channel-forming protein implicated in import of protein precursors into mitochondria.

Gene Ontology (GO) - Molecular Function for TOMM40L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0015288 porin activity IEA --
genes like me logo Genes that share ontologies with TOMM40L: view

Phenotypes for TOMM40L Gene

GenomeRNAi human phenotypes for TOMM40L:
genes like me logo Genes that share phenotypes with TOMM40L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TOMM40L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TOMM40L Gene

Localization for TOMM40L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOMM40L Gene

Mitochondrion outer membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TOMM40L Gene COMPARTMENTS Subcellular localization image for TOMM40L gene
Compartment Confidence
mitochondrion 5
cytosol 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TOMM40L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005741 mitochondrial outer membrane IEA --
GO:0043234 protein complex IDA --
GO:0046930 pore complex IEA --
genes like me logo Genes that share ontologies with TOMM40L: view

Pathways for TOMM40L Gene

genes like me logo Genes that share pathways with TOMM40L: view

Pathways by source for TOMM40L Gene

1 KEGG pathway for TOMM40L Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for TOMM40L Gene

Gene Ontology (GO) - Biological Process for TOMM40L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0008150 biological_process ND --
GO:0015031 protein transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with TOMM40L: view

Transcripts for TOMM40L Gene

Unigene Clusters for TOMM40L Gene

Translocase of outer mitochondrial membrane 40 homolog (yeast)-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TOMM40L

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOMM40L Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2:
SP3:
SP4: -

Relevant External Links for TOMM40L Gene

GeneLoc Exon Structure for
TOMM40L
ECgene alternative splicing isoforms for
TOMM40L

Expression for TOMM40L Gene

mRNA expression in normal human tissues for TOMM40L Gene

Protein differential expression in normal tissues for TOMM40L Gene

This gene is overexpressed in Frontal cortex (10.0), Retina (9.0), Peripheral blood mononuclear cells (8.1), Placenta (8.0), Fetal heart (7.5), Heart (7.5), and Blymphocyte (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TOMM40L Gene

SOURCE GeneReport for Unigene cluster for TOMM40L Gene Hs.321653

genes like me logo Genes that share expressions with TOMM40L: view

Expression partners for TOMM40L Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TOMM40L Gene

Orthologs for TOMM40L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TOMM40L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TOMM40L 35
  • 94.07 (n)
  • 98.22 (a)
TOM40B 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TOMM40L 35
  • 92.32 (n)
  • 99.35 (a)
TOMM40L 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tomm40l 35
  • 92.1 (n)
  • 97.73 (a)
Tomm40l 16
Tomm40l 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TOMM40L 35
  • 99.68 (n)
  • 100 (a)
TOMM40L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tomm40l 35
  • 91.56 (n)
  • 97.08 (a)
oppossum
(Monodelphis domestica)
Mammalia TOMM40L 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TOMM40L 36
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves TOMM40L 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tomm40l 35
  • 70.28 (n)
  • 72.29 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-71l1.1 35
  • 63.37 (n)
  • 62.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4520 36
  • 19 (a)
ManyToMany
Tom40 36
  • 37 (a)
ManyToMany
tomboy40 36
  • 39 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea tomm-40 36
  • 41 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOM40 36
  • 20 (a)
OneToMany
TOM40 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2065 36
  • 37 (a)
OneToMany
Species with no ortholog for TOMM40L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TOMM40L Gene

ENSEMBL:
Gene Tree for TOMM40L (if available)
TreeFam:
Gene Tree for TOMM40L (if available)

Paralogs for TOMM40L Gene

Paralogs for TOMM40L Gene

Selected SIMAP similar genes for TOMM40L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TOMM40L: view

Variants for TOMM40L Gene

Sequence variations from dbSNP and Humsavar for TOMM40L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs34197420 -- 161,228,458(+) GTGGG(-/C)ATCAG reference, frameshift-variant
rs36051050 -- 161,229,071(+) CATTG(-/T)GGCTT frameshift-variant, reference
rs41270855 -- 161,228,131(+) AGGGA(A/G)CAGGT intron-variant
rs61731576 -- 161,228,307(+) TACTC(C/G)GGTAT synonymous-codon, reference
rs74124676 -- 161,227,998(+) AGGAA(A/C/G)TGGGA intron-variant

Relevant External Links for TOMM40L Gene

HapMap Linkage Disequilibrium report
TOMM40L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TOMM40L Gene

Disorders for TOMM40L Gene

Relevant External Links for TOMM40L

Genetic Association Database (GAD)
TOMM40L
Human Genome Epidemiology (HuGE) Navigator
TOMM40L

No disorders were found for TOMM40L Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TOMM40L Gene

Publications for TOMM40L Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for TOMM40L Gene

Sources for TOMM40L Gene

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