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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TOMM40 Gene

protein-coding   GIFtS: 57
GCID: GC19P045394

translocase of outer mitochondrial membrane 40 homolog (yeast)

 Explore 20 diseases affiliated with
TOMM40 via our new
 Human Malady Compendium 
Biological research products
for TOMM40
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Translocase Of Outer Mitochondrial Membrane 40 Homolog (Yeast)1 2     Protein Haymaker2 3
PEREC11 2 3 5     Translocase Of Outer Membrane 40 KDa Subunit Homolog2 3
TOM401 2 3 5     P38.51
C19orf11 2 3     Mitochondrial Import Receptor Subunit TOM40 Homolog2
D19S1177E1 2     Mitochondrial Outer Membrane Protein2
PER-EC11 2     

External Ids:    HGNC: 180011   Entrez Gene: 104522   Ensembl: ENSG000001302047   OMIM: 6080615   UniProtKB: O960083   

Export aliases for TOMM40 gene to outside databases

Previous GC identifers: GC19P046039 GC19P045785 GC19P050070 GC19P050086 GC19P041824


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TOMM40:
TOMM40 is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is
essential for protein import into mitochondria (Humphries et al., 2005 (PubMed 15644312)).(supplied by OMIM, May 2008)

UniProtKB/Swiss-Prot: TOM40_HUMAN, O96008
Function: Channel-forming protein essential for import of protein precursors into mitochondria (By similarity)

Gene Wiki entry for TOMM40


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TOMM40 gene promoter:
         E2F-3a   E2F-5   Sp1   AP-1   ATF-2   E2F-2   E2F   E2F-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTOMM40 promoter sequence
   Search SABiosciences Chromatin IP Primers for TOMM40

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOMM40


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13

TOMM40 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOMM40 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P045394:  view genomic region     (about GC identifiers)

Start:
45,393,826 bp from pter      End:
45,406,946 bp from pter
Size:
13,121 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TOM40_HUMAN, O96008 (See protein sequence)
Recommended Name: Mitochondrial import receptor subunit TOM40 homolog  
Size: 361 amino acids; 37893 Da
Subunit: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which
consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with
mitochondrial targeting sequences
Subcellular location: Mitochondrion outer membrane; Multi-pass membrane protein
Secondary accessions: Q86VW4 Q8WY09 Q8WY10 Q8WY11 Q9BR95
Alternative splicing: 2 isoforms:  O96008-1   O96008-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TOMM40: NX_O96008

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O96008

  • TOMM40 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001122388.1  NP_001122389.1  NP_006105.1  

    ENSEMBL proteins: 
     ENSP00000465611   ENSP00000252487   ENSP00000466084   ENSP00000410339   ENSP00000465032  
     ENSP00000465608   ENSP00000385184  
    Reactome Protein details: O96008
    Human Recombinant Protein Products: 
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    Uscn Proteins for TOMM40

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000299integral to membrane of membrane fraction ----
    GO:0005739NOT mitochondrion IMP11745481
    GO:0005741mitochondrial outer membrane ----
    GO:0005742mitochondrial outer membrane translocase complex IDA12198123
    GO:0016021integral to membrane IDA15644312


    TOMM40 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TOMM40 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR027246 Porin_Euk/Tom40
     IPR023614 Porin_dom

    Graphical View of Domain Structure for InterPro Entry O96008

    ProtoNet protein and cluster: O96008

    UniProtKB/Swiss-Prot: TOM40_HUMAN, O96008
    Similarity: Belongs to the Tom40 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TOM40_HUMAN, O96008
    Function: Channel-forming protein essential for import of protein precursors into mitochondria (By similarity)

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    hsa-miR-3607-3p hsa-miR-125a-5p hsa-miR-1321 hsa-miR-340 hsa-miR-125b hsa-miR-3662 hsa-miR-1231 hsa-miR-324-3p
    SwitchGear 3'UTR luciferase reporter plasmidTOMM40 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008308voltage-gated anion channel activity IEA--
    GO:0008320protein transmembrane transporter activity TAS15644312
    GO:0015288porin activity IEA--


    TOMM40 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TOMM40:
     Synthetic lethal with Ras 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Mitochondrial Protein Import
    Mitochondrial Protein Import1.00
    2Pathogenesis of ALS
    Amyotrophic lateral sclerosis (ALS)0.30
    3Asparagine N-linked glycosylation
    Metabolism of proteins0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for TOMM40
        Mitochondrial Protein Import
    Metabolism of proteins


    1         Kegg Pathway  (Kegg details for TOMM40):
        Amyotrophic lateral sclerosis (ALS)


    TOMM40 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TOMM40

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/32 Interacting proteins for TOMM40 (O960082, 3 ENSP000002524874) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAXQ078123, ENSP000002932884I2D: score=1 STRING: ENSP00000293288
    HLA-BP304803, ENSP000003991684I2D: score=1 STRING: ENSP00000399168
    TOMM22Q9NS693, ENSP000002160344I2D: score=2 STRING: ENSP00000216034
    TOMM7Q9P0U13, ENSP000003512144I2D: score=2 STRING: ENSP00000351214
    SEC24CP539923I2D: score=5 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion TAS--
    GO:0044267cellular protein metabolic process TAS--


    TOMM40 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TOMM40 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TOMM40
    5 Novoseek chemical compound relationships for TOMM40 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    benzodiazepine 45.3 4 20058813 (1), 11158628 (1), 15528269 (1), 10418986 (1)
    steroid 19.4 4 20058813 (1), 11158628 (1), 10418986 (1)
    atp 9.32 1 2163763 (1)
    cholesterol 7.73 6 11158628 (1), 15528269 (1), 19409385 (1), 10418986 (1)
    lipid 0 3 18208519 (1), 16260501 (1)

    2 PharmGKB related drug/compound annotations for TOMM40 gene
    Drug/compound PharmGKB Annotation
    "Antivirals for treatment of HIV infections, combinations"CA  
    ritonavirCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about TOMM40 / TOM40 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TOMM40 gene (3 alternative transcripts): 
    NM_001128916.1  NM_001128917.1  NM_006114.2  

    Unigene Cluster for TOMM40:

    Translocase of outer mitochondrial membrane 40 homolog (yeast)
    Hs.655909  [show with all ESTs]
    Unigene Representative Sequence: BC047528
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589253 ENST00000252487(uc002ozx.4) ENST00000592434 ENST00000426677(uc002paa.4)
    ENST00000589649 ENST00000592041 ENST00000405636(uc002ozz.3 uc002ozy.4)


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    hsa-miR-3607-3p hsa-miR-125a-5p hsa-miR-1321 hsa-miR-340 hsa-miR-125b hsa-miR-3662 hsa-miR-1231 hsa-miR-324-3p
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    Inhib. RNA
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    Additional cDNA sequence: 

    AF043250.1 AF316398.1 AF316399.1 AF316401.1 AF316402.1 BC001779.1 BC006413.1 BC012134.1 
    BC017224.2 BC047528.1 

    22 DOTS entries:

    DT.213308  DT.100877798  DT.100877801  DT.100877802  DT.97766761  DT.91765506  DT.121495293  DT.100772082 
    DT.100877785  DT.121495319  DT.100842091  DT.121495264  DT.95164854  DT.100836039  DT.100877783  DT.120664028 
    DT.100761034  DT.91888090  DT.95164836  DT.100667766  DT.121495313  DT.95100774 

    24/508 AceView cDNA sequences (see all 508):

    CA422508 BE397283 BG283881 BG251414 CA445920 BQ887598 CR600311 NM_006114 
    CR618807 BI518650 CR594218 CR621607 CR597944 H09599 BQ686683 BU854785 
    AI285023 CR593526 CR614435 BM763278 BF114617 CD108318 CR597932 CR623716 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TOMM40    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:              -                                                         
    SP2:              -                                                         
    SP3:                                                                        
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for TOMM40

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TOMM40 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTATAAGTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See TOMM40 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TOMM40

    SOURCE GeneReport for Unigene cluster: Hs.655909
        SABiosciences Expression via Pathway-Focused PCR Array including TOMM40: 
              Mitochondria in human mouse rat

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    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TOMM40

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TOMM40 gene from 8/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tomm401 , 5 translocase of outer mitochondrial membrane 40 homolog more1, 5 88.64(n)1
    93.07(a)1
      7 (9.94 cM)5
    533331  NM_001109748.11  NP_001103218.11 
     197013135 
    lizard
    (Anolis carolinensis)
    Reptilia TOMM406
    --
    82(a)
    1 ↔ 1
    GL343816.1(152587-161092)
    African clawed frog
    (Xenopus laevis)
    Amphibia tomm40-prov2 translocase of outer mitochondrial membrane 40 homolog more 77.19(n)    BC044706.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb68h072 wufb68h07 78.31(n)   322645  BC053295.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tom401 , 3 carrier3
    Translocase of outer membrane 401
    54(a)
    (best of 2)3
    58.33(n)1
    55.59(a)1
      1 7B73
    449781  NM_143746.31  NP_652003.21 
    worm
    (Caenorhabditis elegans)
    Secernentea C18E9.63
    tomm-401
    Protein TOMM-401 45(a)3
    51.48(n)1
    46.26(a)1
      II(8972283-8973474)3
    1744311  NM_063511.21  NP_495912.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G504001 mitochondrial import receptor subunit TOM40 43.22(n)
    32.32(a)
      841462  NM_103923.2  NP_175457.1 
    rice
    (Oryza sativa)
    Liliopsida --
    --
    outer mitochondrial membrane porin, putative, expr...
    outer mitochondrial membrane porin, putative, expr...
    27(a)
    26(a)
    many ↔ many
    many ↔ many
    3(11741307-11746674)
    1(9669749-9674723)


    ENSEMBL Gene Tree for TOMM40 (if available)
    TreeFam Gene Tree for TOMM40 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TOMM40 gene
    TOMM40L2  
    1 SIMAP similar gene for TOMM40 using alignment to 4 protein entries:     TOM40_HUMAN (see all proteins):
    TOMM40L

    TOMM40 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for TOMM40
    PGOHUM00000247707 PGOHUM00000248021 PGOHUM00000246360 PGOHUM00000240337 PGOHUM00000235552


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/297 NCBI SNPs in TOMM40 are shown (see all 297    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1379286911,2
    --45393144(+) AAGCTC/GGACTG 3 -- us2k10--------
    rs1892199081,2
    --45393147(+) CTCGAC/TTGAGT 3 -- us2k10--------
    rs1816202971,2
    --45393175(+) AGCCTA/GGGAAA 3 -- us2k10--------
    rs285339941,2
    F,--45393247(+) GCTACT/ACTGGA 3 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1434732971,2
    --45393352(+) CCTTGC/TCTTTA 3 -- us2k10--------
    rs81029771,2
    C,F,H,--45393473(+) GGAGCC/TCAAGG 3 -- us2k111Minor allele frequency- T:0.06NS EA NA WA 1212
    rs1173104491,2
    F,--45393516(+) AGAGGC/TAGAGT 3 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1505384851,2
    --45393663(+) TCTGGC/GCAATG 3 -- us2k10--------
    rs739369671,2
    C,--45393742(+) CCGCAG/ATGACG 3 -- us2k12Minor allele frequency- A:0.09WA 120
    rs1395649061,2
    --45393825(+) GGCATC/TGTGGG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for TOMM40 (45393826 - 45406946 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TOMM40: --
    Human Gene Mutation Database (HGMD): TOMM40

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TOMM40 for disorders           About GeneDecksing

    OMIM gene information: 608061    OMIM disorders: --

    20 diseases for TOMM40:    About MalaCards
    charcot-marie-tooth neuropathy    charcot-marie-tooth neuropathy type 2    charcot-marie-tooth neuropathy type 2a    charcot-marie-tooth disease
    mitochondrial complex i deficiency    amyotrophic lateral sclerosis (als)    amyotrophic lateral sclerosis    wolfram syndrome 2
    wolfram syndrome    lateral sclerosis    tooth disease    barth syndrome
    coronary heart disease    neuropathy    alzheimer's disease    dementia
    breast cancer    ischemia    cholesterol    hypoxia

    1 disease from the University of Copenhagen DISEASES database for TOMM40:
    Alzheimer's disease

    1 Novoseek disease relationship for TOMM40 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 0 1 16912318 (1)

    Human Genome Epidemiology (HuGE) Navigator: TOMM40 (16 documents)

    Export disorders for TOMM40 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TOMM40 gene, integrated from 9 sources (see all 137):
    (articles sorted by number of sources associating them with TOMM40)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Dissection of the mitochondrial import and assembly pathway for human Tom40. (PubMed id 15644312)1, 2, 3 Humphries A.D.... Ryan M.T. (2005)
    2. Genetic identity and differential expression of p38.5 (Haymaker) in human malignant and non-malignant cells. (PubMed id 11745481)1, 2, 9 Das B.... Norin A.J. (2001)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane. (PubMed id 12198123)1, 2 Johnston A.J.... Ryan M.T. (2002)
    5. Characterization of rat TOM40, a central component of the preprotein translocase of the mitochondrial outer membrane. (PubMed id 10980201)1, 3 Suzuki H....Mihara K. (2000)
    6. Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1. (PubMed id 10520737)1, 2 Freitas E.M.... Dawkins R.L. (1998)
    7. Hippocampal atrophy as a quantitative trait in a geno me-wide association study identifying novel susceptibility genes for Alzheimer' s disease. (PubMed id 19668339)1, 9 Potkin S.G....Macciardi F. (2009)
    8. Genome-wide association analysis of age-at-onset in Al zheimer's disease. (PubMed id 22005931)1 Kamboh M.I....Lopez O.L. (2012)
    9. Levels of cerebrospinal fluid neurofilament light prot ein in healthy elderly vary as a function of TOMM40 variants. (PubMed id 21983493)1 Bruno D....Blennow K. (2012)
    10. Genome-wide association study of Alzheimer's disease. (PubMed id 22832961)1 Kamboh M.I....Barmada M.M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10452 HGNC: 18001 AceView: TOMM40 Ensembl:ENSG00000130204 euGenes: HUgn10452
    ECgene: TOMM40 Kegg: 10452 H-InvDB: TOMM40

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TOMM40 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TOMM40 gene:
    Search GeneIP for patents involving TOMM40

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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