Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TOMM34 Gene

Aliases for TOMM34 Gene

  • Translocase Of Outer Mitochondrial Membrane 34 2 3 5
  • Outer Mitochondrial Membrane Translocase (34kD) 2 3
  • Translocase Of Outer Membrane 34 KDa Subunit 3 4
  • HTom34 3 4
  • URCC3 3 4
  • Mitochondrial Import Receptor Subunit TOM34 3
  • HTOM34P 3
  • TOM34 3

External Ids for TOMM34 Gene

Previous GeneCards Identifiers for TOMM34 Gene

  • GC20M043299
  • GC20M043259
  • GC20M044209
  • GC20M044256
  • GC20M043004
  • GC20M043570
  • GC20M040312

Summaries for TOMM34 Gene

Entrez Gene Summary for TOMM34 Gene

  • The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats. [provided by RefSeq, Jul 2008]

GeneCards Summary for TOMM34 Gene

TOMM34 (Translocase Of Outer Mitochondrial Membrane 34) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include heat shock protein binding. An important paralog of this gene is SPAG1.

UniProtKB/Swiss-Prot for TOMM34 Gene

  • Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state.

Gene Wiki entry for TOMM34 Gene

Additional gene information for TOMM34 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOMM34 Gene

Genomics for TOMM34 Gene

GeneHancer (GH) Regulatory Elements for TOMM34 Gene

Promoters and enhancers for TOMM34 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I044958 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 589.6 +0.4 377 2.9 HDGF FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B TOMM34 PABPC1L PIR52220
GH20I044961 Enhancer 0.7 ENCODE 550.8 -1.5 -1489 0.6 SMARCE1 JUN USF2 CBFA2T3 DPF2 EP300 MITF FOSL1 EGR1 SMARCA4 TOMM34 STK4-AS1
GH20I044909 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 10.7 +49.7 49741 2.9 HDGF CLOCK FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 PABPC1L YWHAB ENSG00000271984 ZSWIM1 SPATA25 TOMM34 STK4-AS1 STK4 DBNDD2 PIR52220
GH20I044965 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.2 -8.4 -8440 7.5 CLOCK MLX DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC SSRP1 STK4 PCIF1 SYS1 ENSG00000271984 PABPC1L DNTTIP1 OSER1 WFDC5 TOMM34 SERINC3
GH20I044989 Enhancer 1.1 Ensembl ENCODE dbSUPER 13 -31.4 -31438 4.6 MEIS2 PKNOX1 JUN ETV1 EBF1 ZFHX2 ZNF316 SCRT2 NFE2 MAFK STK4 STK4-AS1 TOMM34 ENSG00000252021
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TOMM34 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TOMM34 gene promoter:

Genomic Locations for TOMM34 Gene

Genomic Locations for TOMM34 Gene
chr20:44,942,130-44,960,486
(GRCh38/hg38)
Size:
18,357 bases
Orientation:
Minus strand
chr20:43,570,771-43,589,127
(GRCh37/hg19)

Genomic View for TOMM34 Gene

Genes around TOMM34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOMM34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOMM34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOMM34 Gene

Proteins for TOMM34 Gene

  • Protein details for TOMM34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15785-TOM34_HUMAN
    Recommended name:
    Mitochondrial import receptor subunit TOM34
    Protein Accession:
    Q15785
    Secondary Accessions:
    • Q53GH9
    • Q6IBN7
    • Q9NTZ3

    Protein attributes for TOMM34 Gene

    Size:
    309 amino acids
    Molecular mass:
    34559 Da
    Quaternary structure:
    • Interacts with HSP90A, VCP, ATP6M, KIAA0665, AMPK, and DMAP1 through its TPR repeat.

neXtProt entry for TOMM34 Gene

Post-translational modifications for TOMM34 Gene

Other Protein References for TOMM34 Gene

No data available for DME Specific Peptides for TOMM34 Gene

Domains & Families for TOMM34 Gene

Gene Families for TOMM34 Gene

Protein Domains for TOMM34 Gene

Graphical View of Domain Structure for InterPro Entry

Q15785

UniProtKB/Swiss-Prot:

TOM34_HUMAN :
  • Belongs to the Tom34 family.
Family:
  • Belongs to the Tom34 family.
genes like me logo Genes that share domains with TOMM34: view

Function for TOMM34 Gene

Molecular function for TOMM34 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state.

Phenotypes From GWAS Catalog for TOMM34 Gene

Gene Ontology (GO) - Molecular Function for TOMM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
GO:0031072 heat shock protein binding IPI 9660753
genes like me logo Genes that share ontologies with TOMM34: view
genes like me logo Genes that share phenotypes with TOMM34: view

Animal Models for TOMM34 Gene

MGI Knock Outs for TOMM34:

Animal Model Products

CRISPR Products

miRNA for TOMM34 Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TOMM34 Gene

Localization for TOMM34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOMM34 Gene

Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TOMM34 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TOMM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,HDA 21630459
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane IEA,IDA 9324309
genes like me logo Genes that share ontologies with TOMM34: view

Pathways & Interactions for TOMM34 Gene

SuperPathways for TOMM34 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TOMM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion IMP 9324309
genes like me logo Genes that share ontologies with TOMM34: view

No data available for Pathways by source and SIGNOR curated interactions for TOMM34 Gene

Drugs & Compounds for TOMM34 Gene

(6) Drugs for TOMM34 Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Levoleucovorin Approved, Investigational Pharma 777
Tegafur Approved, Investigational Pharma 105
leucovorin Approved Nutra 3402,1193
Antimetabolites Pharma 12587
Antimetabolites, Antineoplastic Pharma 7688
genes like me logo Genes that share compounds with TOMM34: view

Transcripts for TOMM34 Gene

mRNA/cDNA for TOMM34 Gene

Unigene Clusters for TOMM34 Gene

Translocase of outer mitochondrial membrane 34:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOMM34 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1: - -
SP2: - - - -
SP3: - - - - - -
SP4: -
SP5: - - - -
SP6: -

Relevant External Links for TOMM34 Gene

GeneLoc Exon Structure for
TOMM34
ECgene alternative splicing isoforms for
TOMM34

Expression for TOMM34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TOMM34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TOMM34 Gene

This gene is overexpressed in Testis (x4.9).

Protein differential expression in normal tissues from HIPED for TOMM34 Gene

This gene is overexpressed in Testis (10.7), Fetal ovary (8.4), Ovary (8.3), and Peripheral blood mononuclear cells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TOMM34 Gene



Protein tissue co-expression partners for TOMM34 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TOMM34 Gene:

TOMM34

SOURCE GeneReport for Unigene cluster for TOMM34 Gene:

Hs.517066

mRNA Expression by UniProt/SwissProt for TOMM34 Gene:

Q15785-TOM34_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for TOMM34 Gene

  • Kidney(4.4)
  • Nervous system(4.4)
  • Skin(4.3)
  • Liver(4.2)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with TOMM34: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TOMM34 Gene

Orthologs for TOMM34 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TOMM34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOMM34 33 34
  • 99.89 (n)
rat
(Rattus norvegicus)
Mammalia Tomm34 33
  • 89.1 (n)
mouse
(Mus musculus)
Mammalia Tomm34 33 16 34
  • 88.57 (n)
dog
(Canis familiaris)
Mammalia TOMM34 33 34
  • 87.92 (n)
cow
(Bos Taurus)
Mammalia TOMM34 33 34
  • 86.52 (n)
oppossum
(Monodelphis domestica)
Mammalia TOMM34 34
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 43 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TOMM34 33 34
  • 64.17 (n)
lizard
(Anolis carolinensis)
Reptilia TOMM34 34
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tomm34 33 34
  • 58.53 (n)
wufb96b08 33
fruit fly
(Drosophila melanogaster)
Insecta CG18472 34
  • 11 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOM70 34
  • 12 (a)
ManyToMany
TOM71 34
  • 10 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.524 34
  • 12 (a)
OneToMany
Species where no ortholog for TOMM34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TOMM34 Gene

ENSEMBL:
Gene Tree for TOMM34 (if available)
TreeFam:
Gene Tree for TOMM34 (if available)

Paralogs for TOMM34 Gene

Paralogs for TOMM34 Gene

(1) SIMAP similar genes for TOMM34 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TOMM34: view

Variants for TOMM34 Gene

Sequence variations from dbSNP and Humsavar for TOMM34 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000049628 -- 44,959,393(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000275661 -- 44,952,941(-) G/C intron_variant
rs1000305481 -- 44,958,326(-) T/G 5_prime_UTR_variant, intron_variant
rs1000397922 -- 44,945,496(-) G/A intron_variant
rs1000409621 -- 44,945,226(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TOMM34 Gene

Variant ID Type Subtype PubMed ID
nsv1056102 CNV loss 25217958
nsv518547 CNV gain 19592680
nsv586077 CNV gain 21841781

Variation tolerance for TOMM34 Gene

Residual Variation Intolerance Score: 29.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TOMM34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TOMM34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOMM34 Gene

Disorders for TOMM34 Gene

Additional Disease Information for TOMM34

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TOMM34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TOMM34 Gene

Publications for TOMM34 Gene

  1. hTom34: a novel translocase for the import of proteins into human mitochondria. (PMID: 9324309) Nuttall SD … Hoogenraad NJ (DNA and cell biology 1997) 2 3 4 22 58
  2. Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol. (PMID: 11913976) Yang CS … Weiner H (Archives of biochemistry and biophysics 2002) 3 4 22 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. Identification of TOMM34, which shows elevated expression in the majority of human colon cancers, as a novel drug target. (PMID: 16820880) Shimokawa T … Furukawa Y (International journal of oncology 2006) 3 4 58
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58

Products for TOMM34 Gene

Sources for TOMM34 Gene

Content
Loading form....