Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TOMM34 Gene

protein-coding   GIFtS: 51
GCID: GC20M043570

translocase of outer mitochondrial membrane 34

 Explore 3 diseases affiliated with
TOMM34 via our new
 Human Malady Compendium 
Biological research products
for TOMM34
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Translocase Of Outer Mitochondrial Membrane 341 2     URCC32 3
HTOM34P1 2     HTom341
TOM341 2     Mitochondrial Import Receptor Subunit TOM342
Translocase Of Outer Membrane 34 KDa Subunit2 3     Outer Mitochondrial Membrane Translocase (34kD)2

External Ids:    HGNC: 157461   Entrez Gene: 109532   Ensembl: ENSG000000257727   UniProtKB: Q157853   

Export aliases for TOMM34 gene to outside databases

Previous GC identifers: GC20M043299 GC20M043259 GC20M044209 GC20M044256 GC20M043004 GC20M040312


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TOMM34:
The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein
has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into
mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial
membrane, has a weak ATPase activity and contains 6 TPR repeats. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TOM34_HUMAN, Q15785
Function: Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature
portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a
chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state

Gene Wiki entry for TOMM34


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TOMM34 gene promoter:
         AML1a   Pbx1a   Ik-3   NF-AT   GATA-1   NF-AT4   NF-AT2   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTOMM34 promoter sequence
   Search SABiosciences Chromatin IP Primers for TOMM34

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOMM34


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q12-q13.1

TOMM34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOMM34 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M043570:  view genomic region     (about GC identifiers)

Start:
43,570,771 bp from pter      End:
43,589,127 bp from pter
Size:
18,357 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TOM34_HUMAN, Q15785 (See protein sequence)
Recommended Name: Mitochondrial import receptor subunit TOM34  
Size: 309 amino acids; 34559 Da
Subunit: Interacts with HSP90A, VCP, ATP6M, KIAA0665, AMPK, and DMAP1 through its TPR repeat
Subcellular location: Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side
Secondary accessions: Q53GH9 Q6IBN7 Q9NTZ3

Explore the universe of human proteins at neXtProt for TOMM34: NX_Q15785

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15785

  • TOMM34 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006800.2  
    ENSEMBL proteins: 
     ENSP00000361900  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: TOMM34
    OriGene Protein Over-expression Lysate: TOMM34
    OriGene Custom Protein Services for TOMM34 
    GenScript Custom Purified and Recombinant Proteins Services for TOMM34
    Novus Biologicals TOMM34 Protein
    Novus Biologicals TOMM34 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TOMM34

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005741mitochondrial outer membrane IDA9324309
    GO:0016021integral to membrane TAS9324309


    TOMM34 for ontologies           About GeneDecksing



    TOMM34 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 10): TOMM34
    OriGene Custom Antibody Services for TOMM34 
    GenScript Custom Superior Antibodies Services for TOMM34
    Novus Biologicals TOMM34 Antibodies
    Search for Antibodies for TOMM34 at Abcam  
    Uscn Antibodies for TOMM34
    Search ThermoFisher Antibodies for TOMM34

    Assay Products for TOMM34: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TOMM34
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TOMM34


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TOMM34 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR001440 TPR-1
     IPR011990 TPR-like_helical
     IPR013105 TPR_2
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry Q15785

    ProtoNet protein and cluster: Q15785

    UniProtKB/Swiss-Prot: TOM34_HUMAN, Q15785
    Similarity: Belongs to the Tom34 family
    Similarity: Contains 6 TPR repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TOM34_HUMAN, Q15785
    Function: Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature
    portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a
    chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state

    miRNA
    Products:
        
    miRTarBase miRNAs that target TOMM34:
    hsa-mir-16 (MIRT001404)

    OriGene 3'-UTR Clone: TOMM34
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TOMM34
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate TOMM34 (see all 20):
    hsa-miR-607 hsa-miR-4254 hsa-miR-185* hsa-miR-520d-5p hsa-miR-330-5p hsa-miR-1224-3p hsa-miR-4267 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidTOMM34 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TOMM34 (see all 7)
    OriGene shRNA RFP: TOMM34
    OriGene siRNA: TOMM34
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOMM34

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TOMM34

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM34 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM34
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TOMM34 (NM_006809)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOMM34
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM34 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TOMM34
    Search LifeMap BioReagents cell lines for TOMM34

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM34

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031072heat shock protein binding IPI9660753


    TOMM34 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for TOMM34:
     Decreased number of cells in m  Synthetic lethal with c-Myc af 

    Animal Models:
         Mouse knock-out Tomm34tm1Kate for TOMM34
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Tomm34):
     normal 

    TOMM34 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TOMM34

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/12 Interacting proteins for TOMM34 (Q157853 ENSP000003619004) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VCPP550723, ENSP000003517774I2D: score=3 STRING: ENSP00000351777
    RAB11FIP3O751543, ENSP000002623054I2D: score=1 STRING: ENSP00000262305
    HSP90AA1P079003, ENSP000003351534I2D: score=3 STRING: ENSP00000335153
    DMAP1Q9NPF53, ENSP000003126974I2D: score=1 STRING: ENSP00000312697
    ATP6V1DQ9Y5K83, ENSP000002164424I2D: score=2 STRING: ENSP00000216442
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion IMP9324309


    TOMM34 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TOMM34
    Search CenterWatch for drugs/clinical trials and news about TOMM34 / TOM34 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TOMM34 gene: 
    NM_006809.4  

    Unigene Cluster for TOMM34:

    Translocase of outer mitochondrial membrane 34
    Hs.517066  [show with all ESTs]
    Unigene Representative Sequence: AB085681
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000372813(uc002xmy.3)

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: TOMM34
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TOMM34
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate TOMM34 (see all 20):
    hsa-miR-607 hsa-miR-4254 hsa-miR-185* hsa-miR-520d-5p hsa-miR-330-5p hsa-miR-1224-3p hsa-miR-4267 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidTOMM34 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TOMM34 (see all 7)
    OriGene shRNA RFP: TOMM34
    OriGene siRNA: TOMM34
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOMM34
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM34 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM34
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TOMM34 (NM_006809)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOMM34
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM34 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOMM34
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TOMM34
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOMM34
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOMM34

    Additional cDNA sequence: 

    AB085681.1 AK000594.1 AK129538.1 AK222952.1 AK302128.1 AK307655.1 BC001763.1 BC006573.2 
    BC007423.2 BC014907.1 BT020008.1 BT020009.1 CR456765.1 U58970.1 

    15 DOTS entries:

    DT.92466703  DT.86851766  DT.120828512  DT.120828585  DT.120828530  DT.92466706  DT.99999478  DT.100821635 
    DT.100821640  DT.100821641  DT.100821642  DT.100821644  DT.120828589  DT.95068663  DT.95165797 

    24/425 AceView cDNA sequences (see all 425):

    CR615090 BX383447 AA729009 BQ073206 CA394108 BM015673 BU075639 CD675967 
    AA887404 BI828005 CA447053 BM746291 CR591871 BE908341 AI125470 BQ052064 
    BM744535 BF796379 CR590854 BE388278 BM467358 BM743237 BI823933 CR617290 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TOMM34 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
    SP1:                          -                 -                                                                     
    SP2:                          -                 -                                   -     -                           
    SP3:                          -                 -                 -     -     -     -                                 
    SP4:                                            -                                                                     
    SP5:                          -           -     -     -                                                               


    ECgene alternative splicing isoforms for TOMM34

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TOMM34 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTTCTGGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    TOMM34 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesSecondary SpermatocyteGerm Cells, Male Gametocytes
    HeartOutflow TractHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TOMM34 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TOMM34

    SOURCE GeneReport for Unigene cluster: Hs.517066

    UniProtKB/Swiss-Prot: TOM34_HUMAN, Q15785
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including TOMM34: 
              Mitochondria in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOMM34
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TOMM34
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOMM34
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOMM34
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM34

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TOMM34 gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves TOMM341 translocase of outer mitochondrial membrane 34 64.3(n)
    61.15(a)
      419188  XM_417366.3  XP_417366.3 
    lizard
    (Anolis carolinensis)
    Reptilia TOMM346
    --
    45(a)
    1 ↔ 1
    4(143524250-143541959)
    zebrafish
    (Danio rerio)
    Actinopterygii wufb96b082 wufb96b08 74.88(n)   323361  BC049337.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta spag6
    spaghetti
    8(a)
    1 → many
    2R(20046888-20049021)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 3)
    heat shock protein STI, putative, expressed
    (see all 3)
    9(a)
    8(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    6(3041191-3045239)
    6(3034392-3038391)


    ENSEMBL Gene Tree for TOMM34 (if available)
    TreeFam Gene Tree for TOMM34 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TOMM34 gene
    RPAP32  STIP12  TTC12  SPAG12  
    1 SIMAP similar gene for TOMM34 using alignment to 1 protein entry:     TOM34_HUMAN:
    SPAG1

    TOMM34 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/347 NCBI SNPs in TOMM34 are shown (see all 347    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1431734461,2
    --43570352(+) CTCACC/TCCATA 1 -- ds50010--------
    rs756142031,2
    C,F,--43570405(+) TCACTG/TGCTGT 1 -- ds50011Minor allele frequency- T:0.06WA 118
    rs1512331841,2
    --43570424(+) TGAGGA/GCCTTA 1 -- ds50010--------
    rs1140719731,2
    F,--43570425(+) GAGGGC/TCTTAC 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1409352771,2
    --43570448(+) TCCACA/GGTGTT 1 -- ds50010--------
    rs119083481,2
    C,F,H,--43570489(+) ATCTGG/CAACTC 1 -- ds500119Minor allele frequency- C:0.11NA NS EA CSA WA 1351
    rs1848444601,2
    --43570514(+) TTACTC/TAGGGA 1 -- ds50010--------
    rs1178877011,2
    C,F,--43570615(+) CATGTG/TTGTGG 1 -- ds50011Minor allele frequency- T:0.02NA 120
    rs1487535671,2
    --43570692(+) CACTG-/CTAT  
            
    CTATC
    1 -- ds50010--------
    rs1159438651,2
    C,F,--43570747(+) CATGTC/TAATAA 1 -- ds50011Minor allele frequency- T:0.08WA 118

    HapMap Linkage Disequilibrium report for TOMM34 (43570771 - 43589127 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TOMM34: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOMM34
    DNA2.0 Custom Variant and Variant Library Synthesis for TOMM34

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TOMM34 for disorders           About GeneDecksing

    3 diseases for TOMM34:    About MalaCards
    colon cancer    infertility    malaria

    Human Genome Epidemiology (HuGE) Navigator: TOMM34 (1 document)

    Export disorders for TOMM34 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TOMM34 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with TOMM34)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. hTom34: a novel translocase for the import of proteins into human mitochondria. (PubMed id 9324309)1, 2, 3, 9 Nuttall S.D.... Hoogenraad N.J. (1997)
    2. Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol. (PubMed id 11913976)1, 2, 9 Yang C.-S. and Weiner H. (2002)
    3. Identification of TOMM34, which shows elevated expression in the majority of human colon cancers, as a novel drug target. (PubMed id 16820880)1, 2 Shimokawa T....Furukawa Y. (2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins. (PubMed id 11913975)1, 2 Mukhopadhyay A.... Weiner H. (2002)
    7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    8. Characterization of the novel mitochondrial protein import component, Tom34, in mammalian cells. (PubMed id 10101285)1, 2 Chewawiwat N.... Mori M. (1999)
    9. Specific binding of tetratricopeptide repeat proteins to the C- terminal 12-kDa domain of hsp90. (PubMed id 9660753)1, 2 Young J.C.... Hartl F.U. (1998)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10953 HGNC: 15746 AceView: TOMM34 Ensembl:ENSG00000025772 euGenes: HUgn10953
    ECgene: TOMM34 H-InvDB: TOMM34

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TOMM34 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TOMM34 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TOMM34 gene:
    Search GeneIP for patents involving TOMM34

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for TOMM34   OriGene shRNA RFP for TOMM34  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TOMM34   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOMM34  
     OriGene Protein Over-expression Lysate for TOMM34   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TOMM34   OriGene 3'-UTR Clone for TOMM34  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM34   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM34  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for TOMM34   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TOMM34   OriGene Custom Protein Services for TOMM34  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TOMM34
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOMM34
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOMM34
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOMM34
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOMM34
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOMM34
     GenScript Custom Purified and Recombinant Proteins Services for TOMM34 GenScript cDNA clones with any tag delivered in your preferred vector for TOMM34
     GenScript Custom Assay Services for TOMM34 GenScript Custom Superior Antibodies Services for TOMM34
     GenScript Custom overexpressing Cell Line Services for TOMM34 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TOMM34 promoter
     Search Chromatin IP Primers for TOMM34
     RT2 qPCR Primer Assay in human, mouse, rat TOMM34
     Search GNC Networks for TOMM34
     SABiosciences PCR Arrays including human, mouse, rat TOMM34
     Search Tocris compounds for TOMM34
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TOMM34 antibodies
     TOMM34 proteins
     TOMM34 lysates
     Search for Antibodies for TOMM34 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TOMM34
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     TOMM34 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for TOMM34
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM34
     SwitchGear 3'UTR luciferase reporter plasmids for TOMM34
     SwitchGear Promoter luciferase reporter plasmids for TOMM34
     Search ThermoFisher Antibodies for TOMM34
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM34
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TOMM34 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4