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TOMM34 Gene

protein-coding   GIFtS: 56
GCID: GC20M043570

Translocase Of Outer Mitochondrial Membrane 34

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Translocase Of Outer Mitochondrial Membrane 341 2     hTom342 3
Outer Mitochondrial Membrane Translocase (34kD)1 2     HTOM34P2
Translocase Of Outer Membrane 34 KDa Subunit2 3     TOM342
URCC32 3     Mitochondrial Import Receptor Subunit TOM342

External Ids:    HGNC: 157461   Entrez Gene: 109532   Ensembl: ENSG000000257727   UniProtKB: Q157853   

Export aliases for TOMM34 gene to outside databases

Previous GC identifers: GC20M043299 GC20M043259 GC20M044209 GC20M044256 GC20M043004 GC20M040312


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TOMM34 Gene:
The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded
protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import
into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer
mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats. (provided by RefSeq, Jul 2008)

GeneCards Summary for TOMM34 Gene:
TOMM34 (translocase of outer mitochondrial membrane 34) is a protein-coding gene. Diseases associated with TOMM34 include infertility, and breast cancer. GO annotations related to this gene include heat shock protein binding. An important paralog of this gene is TOMM70A.

UniProtKB/Swiss-Prot: TOM34_HUMAN, Q15785
Function: Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature
portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a
chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state

Gene Wiki entry for TOMM34 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TOMM34 gene promoter:
         AML1a   Pbx1a   Ik-3   NF-AT   GATA-1   NF-AT4   NF-AT2   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTOMM34 promoter sequence
   Search Chromatin IP Primers for TOMM34

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TOMM34


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q12-q13.1

TOMM34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOMM34 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M043570:  view genomic region     (about GC identifiers)

Start:
43,570,771 bp from pter      End:
43,589,127 bp from pter
Size:
18,357 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TOM34_HUMAN, Q15785 (See protein sequence)
Recommended Name: Mitochondrial import receptor subunit TOM34  
Size: 309 amino acids; 34559 Da
Subunit: Interacts with HSP90A, VCP, ATP6M, KIAA0665, AMPK, and DMAP1 through its TPR repeat
Secondary accessions: Q53GH9 Q6IBN7 Q9NTZ3

Explore the universe of human proteins at neXtProt for TOMM34: NX_Q15785

Explore proteomics data for TOMM34 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys278
  • Modification sites at PhosphoSitePlus

  • See TOMM34 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006800.2  
    ENSEMBL proteins: 
     ENSP00000361900  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTC: Tetratricopeptide (TTC) repeat domain containing

    5 InterPro protein domains:
     IPR001440 TPR_1
     IPR011990 TPR-like_helical
     IPR013105 TPR_2
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry Q15785

    ProtoNet protein and cluster: Q15785

    UniProtKB/Swiss-Prot: TOM34_HUMAN, Q15785
    Similarity: Belongs to the Tom34 family
    Similarity: Contains 6 TPR repeats


    TOMM34 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TOM34_HUMAN, Q15785
    Function: Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature
    portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a
    chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0031072heat shock protein binding IPI9660753
         
    TOMM34 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TOMM34:
     Decreased number of cells in m  Synthetic lethal with c-Myc af 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Tomm34):
     normal 

    TOMM34 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tomm34tm1Kate for TOMM34

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TOMM34
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TOMM34
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TOMM34

    miRNA
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    miRTarBase miRNAs that target TOMM34:
    hsa-mir-124-3p (MIRT022511), hsa-mir-16-5p (MIRT001404), hsa-mir-155-5p (MIRT020702), hsa-mir-24-3p (MIRT030429)

    Block miRNA regulation of human, mouse, rat TOMM34 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TOMM34 (see all 20):
    hsa-miR-607 hsa-miR-4254 hsa-miR-185* hsa-miR-520d-5p hsa-miR-330-5p hsa-miR-1224-3p hsa-miR-4267 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidTOMM34 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat TOMM34

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    Sino Biological Human cDNA Clone for TOMM34
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM34

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM34


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TOM34_HUMAN, Q15785: Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol3
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion ----
    GO:0005741mitochondrial outer membrane IDA9324309

    TOMM34 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including TOMM34: 
              Mitochondria in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TOMM34

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for TOMM34 (Q157853 ENSP000003619004) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VCPP550723, ENSP000003517774I2D: score=3 STRING: ENSP00000351777
    RAB11FIP3O751543, ENSP000002623054I2D: score=1 STRING: ENSP00000262305
    HSP90AA1P079003, ENSP000003351534I2D: score=3 STRING: ENSP00000335153
    DMAP1Q9NPF53, ENSP000003126974I2D: score=1 STRING: ENSP00000312697
    PRKAA1Q131313, ENSP000003461484I2D: score=2 STRING: ENSP00000346148
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion IMP9324309

    TOMM34 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TOMM34 (TOM34)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TOMM34 gene: 
    NM_006809.4  

    Unigene Cluster for TOMM34:

    Translocase of outer mitochondrial membrane 34
    Hs.517066  [show with all ESTs]
    Unigene Representative Sequence: AB085681
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000372813(uc002xmy.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TOMM34 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TOMM34 (see all 20):
    hsa-miR-607 hsa-miR-4254 hsa-miR-185* hsa-miR-520d-5p hsa-miR-330-5p hsa-miR-1224-3p hsa-miR-4267 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidTOMM34 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TOMM34
    Predesigned siRNA for gene silencing in human, mouse, rat TOMM34
    Clone
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    OriGene clones in human, mouse for TOMM34 (see all 6)
    OriGene ORF clones in mouse, rat for TOMM34
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TOMM34 (NM_006809)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOMM34
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM34
    Primer
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    OriGene qPCR primer pairs and template standards for TOMM34
    OriGene qSTAR qPCR primer pairs in human, mouse for TOMM34
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TOMM34
      QuantiTect SYBR Green Assays in human, mouse, rat TOMM34
      QuantiFast Probe-based Assays in human, mouse, rat TOMM34

    Additional mRNA sequence: 

    AB085681.1 AK000594.1 AK129538.1 AK222952.1 AK302128.1 AK307655.1 BC001763.1 BC006573.2 
    BC007423.2 BC014907.1 BT020008.1 BT020009.1 CR456765.1 U58970.1 

    15 DOTS entries:

    DT.92466703  DT.86851766  DT.120828512  DT.120828585  DT.120828530  DT.92466706  DT.99999478  DT.100821635 
    DT.100821640  DT.100821641  DT.100821642  DT.100821644  DT.120828589  DT.95068663  DT.95165797 

    Selected AceView cDNA sequences (see all 425):

    CD358172 CR590854 BE378775 CB127814 BP353252 CD513630 BI828005 AA369899 
    BI759494 CB160727 BU174223 BM743442 BG029655 BF796366 BU846340 BM799439 
    BQ000302 AI130910 CA447750 AI567286 BU902328 BQ004420 AA514531 BU624505 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TOMM34 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
    SP1:                          -                 -                                                                     
    SP2:                          -                 -                                   -     -                           
    SP3:                          -                 -                 -     -     -     -                                 
    SP4:                                            -                                                                     
    SP5:                          -           -     -     -                                                               


    ECgene alternative splicing isoforms for TOMM34

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TOMM34 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTCTGGGC
    TOMM34 Expression
    About this image


    TOMM34 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             XY Germ Cells Testis Cord
     
     Gonad
             XY Germ Cells Testis Cord
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
    TOMM34 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TOMM34 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517066

    UniProtKB/Swiss-Prot: TOM34_HUMAN, Q15785
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Array including TOMM34: 
              Mitochondria in human mouse rat

    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TOMM34
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    QuantiFast Probe-based Assays in human, mouse, rat TOMM34
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM34

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TOMM34 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tomm341 , 5 translocase of outer mitochondrial membrane 341, 5 88.57(n)1
    88.03(a)1
      2 (84.60 cM)5
    671451  NM_025996.41  NP_080272.11 
     1640535405 
    chicken
    (Gallus gallus)
    Aves TOMM341 translocase of outer mitochondrial membrane 34 64.17(n)
    61.56(a)
      419188  XM_417366.4  XP_417366.3 
    lizard
    (Anolis carolinensis)
    Reptilia TOMM346
    translocase of outer mitochondrial membrane 34
    64(a)
    1 ↔ 1
    4(143523993-143548497)
    zebrafish
    (Danio rerio)
    Actinopterygii wufb96b082 wufb96b08 74.88(n)   323361  BC049337.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG184726
    --
    11(a)
    many ↔ many
    3R(22773590-22775404)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TOM706
    TOM716
    Component of the TOM (translocase of outer membran...
    Mitochondrial outer membrane protein with similari...
    12(a)
    10(a)
    many ↔ many
    many ↔ many
    XIV(398684-400537) YNL121C
    VIII(342349-344268) YHR117W


    ENSEMBL Gene Tree for TOMM34 (if available)
    TreeFam Gene Tree for TOMM34 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TOMM34 gene
    TOMM70A2  TTC12  SPAG12  UNC45A2  UNC45B2  
    1 SIMAP similar gene for TOMM34 using alignment to 1 protein entry:     TOM34_HUMAN:
    SPAG1

    TOMM34 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TOMM34 (see all 427)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1431734461,2
    --43570352(+) CTCACC/TCCATA 1 -- ds50010--------
    rs756142031,2
    C,F--43570405(+) TCACTG/TGCTGT 1 -- ds50011Minor allele frequency- T:0.06WA 118
    rs1512331841,2
    --43570424(+) TGAGGA/GCCTTA 1 -- ds50010--------
    rs1140719731,2
    F--43570425(+) GAGGGC/TCTTAC 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1409352771,2
    --43570448(+) TCCACA/GGTGTT 1 -- ds50010--------
    rs119083481,2
    C,F,H--43570489(+) ATCTGG/CAACTC 1 -- ds500119Minor allele frequency- C:0.11NA NS EA CSA WA 1351
    rs1848444601,2
    --43570514(+) TTACTC/TAGGGA 1 -- ds50010--------
    rs1178877011,2
    C,F--43570615(+) CATGTG/TTGTGG 1 -- ds50011Minor allele frequency- T:0.02NA 120
    rs1487535671,2
    C--43570692(+) CACTG-/CTAT  
            
    CTATC
    1 -- ds50010--------
    rs1159438651,2
    C,F--43570747(+) CATGTC/TAATAA 1 -- ds50011Minor allele frequency- T:0.08WA 118

    HapMap Linkage Disequilibrium report for TOMM34 (43570771 - 43589127 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TOMM34:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv518547CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TOMM34
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for TOMM34:    
    About MalaCards
    infertility    breast cancer


    TOMM34 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TOMM34
    Human Genome Epidemiology (HuGE) Navigator: TOMM34 (1 document)

    Export disorders for TOMM34 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TOMM34 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with TOMM34)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. hTom34: a novel translocase for the import of proteins into human mitochondria. (PubMed id 9324309)1, 2, 3, 9 Nuttall S.D.... Hoogenraad N.J. (DNA Cell Biol. 1997)
    2. Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol. (PubMed id 11913976)1, 2, 9 Yang C.-S. and Weiner H. (Arch. Biochem. Biophys. 2002)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Identification of TOMM34, which shows elevated expression in the majority of human colon cancers, as a novel drug target. (PubMed id 16820880)1, 2 Shimokawa T....Furukawa Y. (Int. J. Oncol. 2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins. (PubMed id 11913975)1, 2 Mukhopadhyay A.... Weiner H. (Arch. Biochem. Biophys. 2002)
    8. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    9. Characterization of the novel mitochondrial protein import component, Tom34, in mammalian cells. (PubMed id 10101285)1, 2 Chewawiwat N.... Mori M. (J. Biochem. 1999)
    10. Specific binding of tetratricopeptide repeat proteins to the C- terminal 12-kDa domain of hsp90. (PubMed id 9660753)1, 2 Young J.C.... Hartl F.U. (J. Biol. Chem. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10953 HGNC: 15746 AceView: TOMM34 Ensembl:ENSG00000025772 euGenes: HUgn10953
    ECgene: TOMM34 H-InvDB: TOMM34

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TOMM34 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TOMM34 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TOMM34 gene:
    Search GeneIP for patents involving TOMM34

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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