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Aliases for TOMM34 Gene

Aliases for TOMM34 Gene

  • Translocase Of Outer Mitochondrial Membrane 34 2 3
  • Outer Mitochondrial Membrane Translocase (34kD) 2 3
  • Translocase Of Outer Membrane 34 KDa Subunit 3 4
  • HTom34 3 4
  • URCC3 3 4
  • HTOM34P 3
  • TOM34 3

External Ids for TOMM34 Gene

Previous GeneCards Identifiers for TOMM34 Gene

  • GC20M043299
  • GC20M043259
  • GC20M044209
  • GC20M044256
  • GC20M043004
  • GC20M043570
  • GC20M040312

Summaries for TOMM34 Gene

Entrez Gene Summary for TOMM34 Gene

  • The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats. [provided by RefSeq, Jul 2008]

GeneCards Summary for TOMM34 Gene

TOMM34 (Translocase Of Outer Mitochondrial Membrane 34) is a Protein Coding gene. GO annotations related to this gene include heat shock protein binding. An important paralog of this gene is SPAG1.

UniProtKB/Swiss-Prot for TOMM34 Gene

  • Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state.

Gene Wiki entry for TOMM34 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOMM34 Gene

Genomics for TOMM34 Gene

Regulatory Elements for TOMM34 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TOMM34 Gene

Chromosome:
20
Start:
44,942,130 bp from pter
End:
44,960,486 bp from pter
Size:
18,357 bases
Orientation:
Minus strand

Genomic View for TOMM34 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TOMM34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOMM34 Gene

Proteins for TOMM34 Gene

  • Protein details for TOMM34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15785-TOM34_HUMAN
    Recommended name:
    Mitochondrial import receptor subunit TOM34
    Protein Accession:
    Q15785
    Secondary Accessions:
    • Q53GH9
    • Q6IBN7
    • Q9NTZ3

    Protein attributes for TOMM34 Gene

    Size:
    309 amino acids
    Molecular mass:
    34559 Da
    Quaternary structure:
    • Interacts with HSP90A, VCP, ATP6M, KIAA0665, AMPK, and DMAP1 through its TPR repeat.

neXtProt entry for TOMM34 Gene

Proteomics data for TOMM34 Gene at MOPED

Post-translational modifications for TOMM34 Gene

  • Ubiquitination at Lys 278
  • Modification sites at PhosphoSitePlus

Other Protein References for TOMM34 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TOMM34 Gene

Domains & Families for TOMM34 Gene

Gene Families for TOMM34 Gene

Protein Domains for TOMM34 Gene

Graphical View of Domain Structure for InterPro Entry

Q15785

UniProtKB/Swiss-Prot:

TOM34_HUMAN :
  • Belongs to the Tom34 family.
  • Contains 6 TPR repeats.
Family:
  • Belongs to the Tom34 family.
Similarity:
  • Contains 6 TPR repeats.
genes like me logo Genes that share domains with TOMM34: view

Function for TOMM34 Gene

Molecular function for TOMM34 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state.

Gene Ontology (GO) - Molecular Function for TOMM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0031072 heat shock protein binding IPI 9660753
genes like me logo Genes that share ontologies with TOMM34: view
genes like me logo Genes that share phenotypes with TOMM34: view

Animal Models for TOMM34 Gene

MGI Knock Outs for TOMM34:

Animal Model Products

CRISPR Products

miRNA for TOMM34 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TOMM34

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TOMM34 Gene

Localization for TOMM34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOMM34 Gene

Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TOMM34 Gene COMPARTMENTS Subcellular localization image for TOMM34 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for TOMM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion --
GO:0005741 mitochondrial outer membrane IDA 9324309
genes like me logo Genes that share ontologies with TOMM34: view

Pathways & Interactions for TOMM34 Gene

SuperPathways for TOMM34 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TOMM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion IMP 9324309
genes like me logo Genes that share ontologies with TOMM34: view

No data available for Pathways by source and SIGNOR curated interactions for TOMM34 Gene

Drugs & Compounds for TOMM34 Gene

(1) Drugs for TOMM34 Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tegafur Pharma 75
genes like me logo Genes that share compounds with TOMM34: view

Transcripts for TOMM34 Gene

mRNA/cDNA for TOMM34 Gene

Unigene Clusters for TOMM34 Gene

Translocase of outer mitochondrial membrane 34:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TOMM34

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOMM34 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1: - -
SP2: - - - -
SP3: - - - - - -
SP4: -
SP5: - - - -
SP6: -

Relevant External Links for TOMM34 Gene

GeneLoc Exon Structure for
TOMM34
ECgene alternative splicing isoforms for
TOMM34

Expression for TOMM34 Gene

mRNA expression in normal human tissues for TOMM34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TOMM34 Gene

This gene is overexpressed in Testis (x4.9).

Protein differential expression in normal tissues from HIPED for TOMM34 Gene

This gene is overexpressed in Testis (10.7), Fetal ovary (8.4), Ovary (8.3), and Peripheral blood mononuclear cells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TOMM34 Gene



SOURCE GeneReport for Unigene cluster for TOMM34 Gene Hs.517066

mRNA Expression by UniProt/SwissProt for TOMM34 Gene

Q15785-TOM34_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expression patterns with TOMM34: view

Protein tissue co-expression partners for TOMM34 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for TOMM34 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TOMM34 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TOMM34 35
  • 86.52 (n)
  • 83.17 (a)
TOMM34 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TOMM34 35
  • 87.92 (n)
  • 83.17 (a)
TOMM34 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tomm34 35
  • 88.57 (n)
  • 88.03 (a)
Tomm34 16
Tomm34 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TOMM34 35
  • 99.89 (n)
  • 100 (a)
TOMM34 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tomm34 35
  • 89.1 (n)
  • 88.35 (a)
oppossum
(Monodelphis domestica)
Mammalia TOMM34 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TOMM34 35
  • 64.17 (n)
  • 61.56 (a)
TOMM34 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TOMM34 36
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tomm34 35
  • 58.53 (n)
  • 54.24 (a)
wufb96b08 35
tomm34 36
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG18472 36
  • 11 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOM70 36
  • 12 (a)
ManyToMany
TOM71 36
  • 10 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.524 36
  • 12 (a)
OneToMany
Species with no ortholog for TOMM34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TOMM34 Gene

ENSEMBL:
Gene Tree for TOMM34 (if available)
TreeFam:
Gene Tree for TOMM34 (if available)

Paralogs for TOMM34 Gene

Paralogs for TOMM34 Gene

(1) SIMAP similar genes for TOMM34 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TOMM34: view

Variants for TOMM34 Gene

Sequence variations from dbSNP and Humsavar for TOMM34 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1983688 -- 44,959,407(-) cagaa(A/G)aatag intron-variant, upstream-variant-2KB
rs2144649 -- 44,960,678(-) GAAAT(G/T)AGAGT upstream-variant-2KB
rs2180292 -- 44,960,992(-) TGATT(C/G)CCAAA upstream-variant-2KB
rs2234192 -- 44,961,105(-) ttgaa(C/G)agcaa upstream-variant-2KB
rs2234194 -- 44,960,466(-) GTCTC(G/T)CAGGC utr-variant-5-prime, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TOMM34 Gene

Variant ID Type Subtype PubMed ID
nsv518547 CNV Gain 19592680

Variation tolerance for TOMM34 Gene

Residual Variation Intolerance Score: 29.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TOMM34 Gene

HapMap Linkage Disequilibrium report
TOMM34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOMM34 Gene

Disorders for TOMM34 Gene

Relevant External Links for TOMM34

Genetic Association Database (GAD)
TOMM34
Human Genome Epidemiology (HuGE) Navigator
TOMM34
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TOMM34
genes like me logo Genes that share disorders with TOMM34: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TOMM34 Gene

Publications for TOMM34 Gene

  1. hTom34: a novel translocase for the import of proteins into human mitochondria. (PMID: 9324309) Nuttall S.D. … Hoogenraad N.J. (DNA Cell Biol. 1997) 2 23 67
  2. In vitro methylation of nuclear respiratory factor-2 binding sites suppresses the promoter activity of the human TOMM70 gene. (PMID: 18852034) Blesa J.R. … HernA!ndez-Yago J. (Gene 2008) 23 67
  3. NRF-2 transcription factor is required for human TOMM20 gene expression. (PMID: 17300881) Blesa J.R. … HernA!ndez-Yago J. (Gene 2007) 23 67
  4. Distinct functional contributions of 2 GABP-NRF-2 recognition sites within the context of the human TOMM70 promoter. (PMID: 17167546) Blesa J.R. … HernA!ndez-Yago J. (Biochem. Cell Biol. 2006) 23 67
  5. The enteropathogenic Escherichia coli (EPEC) Map effector is imported into the mitochondrial matrix by the TOM/Hsp70 system and alters organelle morphology. (PMID: 16548893) Papatheodorou P. … Rassow J. (Cell. Microbiol. 2006) 23 67

Products for TOMM34 Gene

Sources for TOMM34 Gene

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