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TOMM22 Gene

protein-coding   GIFtS: 57
GCID: GC22P039077

Translocase Of Outer Mitochondrial Membrane 22 Homolog (Yeast)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Translocase Of Outer Mitochondrial Membrane 22 Homolog (Yeast)1 2     MSTP0652
TOM222 3 5     Mitochondrial Import Receptor Subunit TOM22 Homolog2
Translocase Of Outer Membrane 22 KDa Subunit Homolog2 3     Mitochondrial Import Receptor Tom222
1C9-22 3     hTom223
MST0652     

External Ids:    HGNC: 180021   Entrez Gene: 569932   Ensembl: ENSG000001002167   OMIM: 6070465   UniProtKB: Q9NS693   

Export aliases for TOMM22 gene to outside databases

Previous GC identifers: GC22P035692 GC22P037321 GC22P037402 GC22P022044


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TOMM22 Gene:
The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded
protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic
preproteins into the mitochondrion. (provided by RefSeq, Jul 2008)

GeneCards Summary for TOMM22 Gene:
TOMM22 (translocase of outer mitochondrial membrane 22 homolog (yeast)) is a protein-coding gene. Diseases associated with TOMM22 include intrahepatic cholangiocarcinoma, and cholangiocarcinoma. GO annotations related to this gene include protein transmembrane transporter activity.

UniProtKB/Swiss-Prot: TOM22_HUMAN, Q9NS69
Function: Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex)
responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins.
Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the
movement of preproteins into the translocation pore

Gene Wiki entry for TOMM22 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the TOMM22 gene promoter:
         SRY   AML1a   POU2F1   POU2F1a   FOXD1   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTOMM22 promoter sequence
   Search Chromatin IP Primers for TOMM22

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TOMM22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12-q13   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q12-q13

TOMM22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOMM22 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P039077:  view genomic region     (about GC identifiers)

Start:
39,077,953 bp from pter      End:
39,080,818 bp from pter
Size:
2,866 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TOM22_HUMAN, Q9NS69 (See protein sequence)
Recommended Name: Mitochondrial import receptor subunit TOM22 homolog  
Size: 142 amino acids; 15522 Da
Subunit: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which
consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts
with TOMM40. Interacts with PPP2R2B (By similarity)

Explore the universe of human proteins at neXtProt for TOMM22: NX_Q9NS69

Explore proteomics data for TOMM22 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys141
  • Modification sites at PhosphoSitePlus

  • See TOMM22 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_064628.1  
    ENSEMBL proteins: 
     ENSP00000216034  
    Reactome Protein details: Q9NS69

    TOMM22 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005683 Tom22

    Graphical View of Domain Structure for InterPro Entry Q9NS69

    ProtoNet protein and cluster: Q9NS69

    UniProtKB/Swiss-Prot: TOM22_HUMAN, Q9NS69
    Domain: Requires the transmembrane domain (TMD), a short segment (the import sequence) in the cytoplasmic domain
    localizing separately from the TMD and the C-tail signal in the C-terminal domain for efficient targeting and
    integration into the TOM complex (By similarity). The N-terminal domain (residues 1-62) is important for binding
    to the unfolded mature imported proteins. Residues (49-71) of the cytoplasmic domain interacts with TOMM20 while
    the C-terminal segment (residues 63-82) binds presequence of preproteins
    Similarity: Belongs to the Tom22 family


    TOMM22 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TOM22_HUMAN, Q9NS69
    Function: Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex)
    responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins.
    Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the
    movement of preproteins into the translocation pore

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12198123
    GO:0008320protein transmembrane transporter activity TAS15644312
         
    TOMM22 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TOMM22:
     Decreased cell number, increas  Decreased viability of wild-ty  Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TOMM22
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TOMM22
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TOMM22

    miRNA
    Products:
        
    miRTarBase miRNAs that target TOMM22:
    hsa-mir-296-3p (MIRT038383), hsa-mir-24-3p (MIRT030384), hsa-mir-99a-5p (MIRT048629), ebv-mir-bart16 (MIRT005470)

    Block miRNA regulation of human, mouse, rat TOMM22 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TOMM22 (see all 10):
    hsa-miR-4291 hsa-miR-455-5p hsa-miR-922 hsa-miR-759 hsa-miR-1227 hsa-miR-214 hsa-miR-548t hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidTOMM22 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TOMM22
    Predesigned siRNA for gene silencing in human, mouse, rat TOMM22

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: TOMM22 (NM_020243)
    Sino Biological Human cDNA Clone for TOMM22
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM22

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM22


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TOM22_HUMAN, Q9NS69: Mitochondrion outer membrane; Single-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol3
    endoplasmic reticulum1
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005741mitochondrial outer membrane ----
    GO:0005742mitochondrial outer membrane translocase complex IDA12198123
    GO:0005743mitochondrial inner membrane IEA--
    GO:0016021integral component of membrane IDA15644312

    TOMM22 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TOMM22 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    2Mitochondrial Protein Import
    Mitochondrial Protein Import

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for TOMM22
        Mitochondrial protein import



    TOMM22 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including TOMM22: 
              Mitochondria in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TOMM22

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TOMM22 (Q9NS691, 3 ENSP000002160344) via UniProtKB, MINT, STRING, and/or I2D (see all 84)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TOMM7Q9P0U11, 3, ENSP000003512144EBI-1047508,EBI-1180558 I2D: score=2 STRING: ENSP00000351214
    BAXQ078123, ENSP000002932884I2D: score=1 STRING: ENSP00000293288
    PHLDA3Q9Y5J53, ENSP000003562784I2D: score=1 STRING: ENSP00000356278
    PTP4A3O753653, ENSP000003322744I2D: score=1 STRING: ENSP00000332274
    TOMM40O960083, ENSP000002524874I2D: score=2 STRING: ENSP00000252487
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion TAS14557246
    GO:0006886intracellular protein transport ----
    GO:0044267cellular protein metabolic process TAS--
    GO:0045040protein import into mitochondrial outer membrane IDA15644312

    TOMM22 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TOMM22 (TOM22)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TOMM22 gene: 
    NM_020243.4  

    Unigene Cluster for TOMM22:

    Translocase of outer mitochondrial membrane 22 homolog (yeast)
    Hs.595072  [show with all ESTs]
    Unigene Representative Sequence: NM_020243
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216034(uc003awe.3) ENST00000492561
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TOMM22 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TOMM22 (see all 10):
    hsa-miR-4291 hsa-miR-455-5p hsa-miR-922 hsa-miR-759 hsa-miR-1227 hsa-miR-214 hsa-miR-548t hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidTOMM22 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TOMM22
    Predesigned siRNA for gene silencing in human, mouse, rat TOMM22
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    OriGene ORF clones in mouse, rat for TOMM22
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TOMM22 (NM_020243)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM22
    Primer
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    OriGene qPCR primer pairs and template standards for TOMM22
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TOMM22
      QuantiTect SYBR Green Assays in human, mouse, rat TOMM22
      QuantiFast Probe-based Assays in human, mouse, rat TOMM22

    Additional mRNA sequence: 

    AB040119.1 AB041906.1 AF163256.1 AK024731.1 AK223021.1 AK312076.1 BC009363.2 CR456475.1 

    14 DOTS entries:

    DT.100819731  DT.87016592  DT.447534  DT.120652130  DT.95364346  DT.100036926  DT.95306022  DT.91767780 
    DT.95206319  DT.120652076  DT.87012395  DT.91818530  DT.120652080  DT.120652132 

    Selected AceView cDNA sequences (see all 515):

    AW082589 CR619995 AF163256 BQ961547 AA975153 CR456410 AA904176 BM832285 
    AU105636 CR617759 AI122822 CA438687 BM021487 AL050345 CD626926 NM_015373 
    AA463665 BM831784 NM_001002880 AA236361 AI755110 BM831475 AA733214 BM773096 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TOMM22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACACAATGT
    TOMM22 Expression
    About this image


    TOMM22 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Negative 2 Thymocytes Thymus
     
     Eye (Sensory Organs)
             Retina
    TOMM22 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TOMM22 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.595072

    UniProtKB/Swiss-Prot: TOM22_HUMAN, Q9NS69
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Array including TOMM22: 
              Mitochondria in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TOMM22 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tomm221 , 5 translocase of outer mitochondrial membrane 22 homolog more1, 5 89.57(n)1
    93.89(a)1
      15 (37.85 cM)5
    2236961  NM_172609.31  NP_766197.21 
     796708615 
    chicken
    (Gallus gallus)
    Aves TOMM226
    translocase of outer mitochondrial membrane 22 hom...
    51(a)
    1 ↔ 1
    1(50701667-50704068)
    lizard
    (Anolis carolinensis)
    Reptilia TOMM226
    translocase of outer mitochondrial membrane 22 hom...
    77(a)
    1 ↔ 1
    5(24144229-24155133)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.67352 Transcribed sequence with weak similarity to protein more 73.2(n)    142016441 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa02g112 Danio rerio, clone IMAGE5410294, mRNA 72.7(n)    BC047825.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mge1 maggie 52.98(n)
    52.63(a)
      38459  NM_079186.4  NP_523910.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tomm-226
    Protein TOMM-22 (tomm-22) mRNA, complete cds
    34(a)
    1 ↔ 1
    II(468370-470475) WBGene00021133


    ENSEMBL Gene Tree for TOMM22 (if available)
    TreeFam Gene Tree for TOMM22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TOMM22 gene
    1 SIMAP similar gene for TOMM22 using alignment to 1 protein entry:     TOM22_HUMAN:
    MST065

    TOMM22 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for TOMM22 (see all 7)
    PGOHUM00000238936 PGOHUM00000242398 PGOHUM00000248357 PGOHUM00000237847 PGOHUM00000246123


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TOMM22 (see all 127)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1501064311,2
    C--39076085(+) GGTCAC/TGAGTT 1 -- us2k10--------
    rs1835540291,2
    --39076128(+) ATCTCC/TACTAA 1 -- us2k10--------
    rs413337481,2
    F--39076272(+) CGACAA/CGCAAG 1 -- us2k11Minor allele frequency- C:0.44EA 162
    rs48218131,2
    C,F,A,H--39076273(+) GACAGC/AGCAAG 1 -- us2k13Minor allele frequency- A:0.33NA 6
    rs781233721,2
    C,F--39076365(+) AAATCT/AATGTA 1 -- us2k12Minor allele frequency- A:0.04WA 120
    rs1414890781,2
    --39076453(+) GACACA/GCCGCA 1 -- us2k10--------
    rs169992241,2
    C,F,H--39076587(+) CTACCA/GAGTAA 1 -- us2k125Minor allele frequency- G:0.12NA NS EA WA 2782
    rs775905181,2
    C--39076595(+) TAAAAC/GATGGC 1 -- us2k10--------
    rs1878039151,2
    --39076760(+) ACTTGA/GGGAGG 1 -- us2k10--------
    rs746576881,2
    F--39076777(+) CAGTCG/AGATTG 1 -- us2k11Minor allele frequency- A:0.03NA 120

    HapMap Linkage Disequilibrium report for TOMM22 (39077953 - 39080818 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TOMM22:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508733CNV Insertion20534489
    nsv915067CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607046    OMIM disorders: --

    3 diseases for TOMM22:    
    About MalaCards
    intrahepatic cholangiocarcinoma    cholangiocarcinoma    malaria


    TOMM22 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TOMM22
    Human Genome Epidemiology (HuGE) Navigator: TOMM22 (1 document)

    Export disorders for TOMM22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TOMM22 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with TOMM22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and functional analysis of human Tom22 for protein import into mitochondria. (PubMed id 10982837)1, 2, 3, 9 Yano M.... Mori M. (Mol. Cell. Biol. 2000)
    2. Identification of mammalian Tom22 as a subunit of the preprotein translocase of the mitochondrial outer membrane. (PubMed id 10900208)1, 2, 3 Saeki K....Mihara K. (J. Biol. Chem. 2000)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    8. TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax. (PubMed id 17096026)1, 9 Bellot G....Vallette F.M. (Cell Death Differ. 2007)
    9. Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity. (PubMed id 14699115)1, 9 Yano M....Mori M. (J. Biol. Chem. 2004)
    10. Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane. (PubMed id 12198123)1, 9 Johnston A.J.... Ryan M.T. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56993 HGNC: 18002 AceView: TOMM22andPGEA1 Ensembl:ENSG00000100216 euGenes: HUgn56993
    ECgene: TOMM22 H-InvDB: TOMM22

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TOMM22 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TOMM22 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TOMM22 gene:
    Search GeneIP for patents involving TOMM22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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