Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TOMM22 Gene

Aliases for TOMM22 Gene

  • Translocase Of Outer Mitochondrial Membrane 22 2 3 5
  • Translocase Of Outer Membrane 22 KDa Subunit Homolog 3 4
  • 1C9-2 3 4
  • TOM22 3 4
  • Translocase Of Outer Mitochondrial Membrane 22 Homolog (Yeast) 2
  • Translocase Of Outer Mitochondrial Membrane 22 Homolog 3
  • Mitochondrial Import Receptor Subunit TOM22 Homolog 3
  • Mitochondrial Import Receptor Tom22 3
  • MSTP065 3
  • MST065 3
  • HTom22 4

External Ids for TOMM22 Gene

Previous GeneCards Identifiers for TOMM22 Gene

  • GC22P035692
  • GC22P037321
  • GC22P037402
  • GC22P039077
  • GC22P022044

Summaries for TOMM22 Gene

Entrez Gene Summary for TOMM22 Gene

  • The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion. [provided by RefSeq, Jul 2008]

GeneCards Summary for TOMM22 Gene

TOMM22 (Translocase Of Outer Mitochondrial Membrane 22) is a Protein Coding gene. Diseases associated with TOMM22 include Spinocerebellar Ataxia 12. Among its related pathways are Pink/Parkin Mediated Mitophagy and Mitochondrial protein import. GO annotations related to this gene include protein transmembrane transporter activity.

UniProtKB/Swiss-Prot for TOMM22 Gene

  • Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore.

Gene Wiki entry for TOMM22 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOMM22 Gene

Genomics for TOMM22 Gene

Regulatory Elements for TOMM22 Gene

Enhancers for TOMM22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F038775 0.2 Ensembl 5.6 +94.0 93953 0.6 ZFHX2 PRDM10 KDM1A EGR2 ENSG00000228274 TOMM22 GC22M041089 PIR46258 ENSG00000273076
GH22F039170 1.7 FANTOM5 Ensembl ENCODE 4.9 +493.6 493553 9.8 MLX ARID4B FEZF1 DMAP1 ZNF2 SLC30A9 ZNF143 FOS ZNF263 SP5 PDGFB APOBEC3G SUN2 ENSG00000273076 TOMM22 ATF4 APOBEC3D JOSD1 GTPBP1 APOBEC3H
GH22F038681 0.2 ENCODE 0.8 +0.2 154 1.9 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 CBY1 SNORD83B SNORD83A KDELR3 ENSG00000230149 ENSG00000273076 PRDX3P1 ENSG00000230912 CSNK1E ENSG00000228274
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TOMM22 on UCSC Golden Path with GeneCards custom track

Promoters for TOMM22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000085525 153 1800 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207

Genomic Location for TOMM22 Gene

Chromosome:
22
Start:
38,681,948 bp from pter
End:
38,685,421 bp from pter
Size:
3,474 bases
Orientation:
Plus strand

Genomic View for TOMM22 Gene

Genes around TOMM22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOMM22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOMM22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOMM22 Gene

Proteins for TOMM22 Gene

  • Protein details for TOMM22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS69-TOM22_HUMAN
    Recommended name:
    Mitochondrial import receptor subunit TOM22 homolog
    Protein Accession:
    Q9NS69

    Protein attributes for TOMM22 Gene

    Size:
    142 amino acids
    Molecular mass:
    15522 Da
    Quaternary structure:
    • Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70) (PubMed:18331822). Interacts with TOMM40. Interacts with PPP2R2B (By similarity).

neXtProt entry for TOMM22 Gene

Post-translational modifications for TOMM22 Gene

  • Ubiquitination at Lys 141
  • Modification sites at PhosphoSitePlus

Other Protein References for TOMM22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TOMM22 Gene

Domains & Families for TOMM22 Gene

Protein Domains for TOMM22 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NS69

UniProtKB/Swiss-Prot:

TOM22_HUMAN :
  • Requires the transmembrane domain (TMD), a short segment (the import sequence) in the cytoplasmic domain localizing separately from the TMD and the C-tail signal in the C-terminal domain for efficient targeting and integration into the TOM complex (By similarity). The N-terminal domain (residues 1-62) is important for binding to the unfolded mature imported proteins. Residues (49-71) of the cytoplasmic domain interacts with TOMM20 while the C-terminal segment (residues 63-82) binds presequence of preproteins.
  • Belongs to the Tom22 family.
Domain:
  • Requires the transmembrane domain (TMD), a short segment (the import sequence) in the cytoplasmic domain localizing separately from the TMD and the C-tail signal in the C-terminal domain for efficient targeting and integration into the TOM complex (By similarity). The N-terminal domain (residues 1-62) is important for binding to the unfolded mature imported proteins. Residues (49-71) of the cytoplasmic domain interacts with TOMM20 while the C-terminal segment (residues 63-82) binds presequence of preproteins.
Family:
  • Belongs to the Tom22 family.
genes like me logo Genes that share domains with TOMM22: view

Function for TOMM22 Gene

Molecular function for TOMM22 Gene

UniProtKB/Swiss-Prot Function:
Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore.

Gene Ontology (GO) - Molecular Function for TOMM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12198123
GO:0008320 protein transmembrane transporter activity TAS 15644312
GO:0015266 contributes_to protein channel activity IBA --
genes like me logo Genes that share ontologies with TOMM22: view
genes like me logo Genes that share phenotypes with TOMM22: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TOMM22 Gene

Localization for TOMM22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOMM22 Gene

Mitochondrion outer membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TOMM22 Gene COMPARTMENTS Subcellular localization image for TOMM22 gene
Compartment Confidence
mitochondrion 5
cytosol 4
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TOMM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA --
GO:0005741 mitochondrial outer membrane TAS --
GO:0005742 mitochondrial outer membrane translocase complex IDA 12198123
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with TOMM22: view

Pathways & Interactions for TOMM22 Gene

genes like me logo Genes that share pathways with TOMM22: view

Pathways by source for TOMM22 Gene

Gene Ontology (GO) - Biological Process for TOMM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS 14557246
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0015031 protein transport IEA --
GO:0016236 macroautophagy TAS --
genes like me logo Genes that share ontologies with TOMM22: view

No data available for SIGNOR curated interactions for TOMM22 Gene

Transcripts for TOMM22 Gene

mRNA/cDNA for TOMM22 Gene

Unigene Clusters for TOMM22 Gene

Translocase of outer mitochondrial membrane 22 homolog (yeast):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOMM22 Gene

No ASD Table

Relevant External Links for TOMM22 Gene

GeneLoc Exon Structure for
TOMM22
ECgene alternative splicing isoforms for
TOMM22

Expression for TOMM22 Gene

mRNA expression in normal human tissues for TOMM22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TOMM22 Gene

This gene is overexpressed in Nasal epithelium (26.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TOMM22 Gene



Protein tissue co-expression partners for TOMM22 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TOMM22 Gene:

TOMM22

SOURCE GeneReport for Unigene cluster for TOMM22 Gene:

Hs.595072

mRNA Expression by UniProt/SwissProt for TOMM22 Gene:

Q9NS69-TOM22_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with TOMM22: view

Primer Products

No data available for mRNA differential expression in normal tissues for TOMM22 Gene

Orthologs for TOMM22 Gene

This gene was present in the common ancestor of animals.

Orthologs for TOMM22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOMM22 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 95 (a)
OneToMany
-- 35
  • 90 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TOMM22 34 35
  • 91.93 (n)
mouse
(Mus musculus)
Mammalia Tomm22 34 16 35
  • 89.57 (n)
rat
(Rattus norvegicus)
Mammalia Tomm22 34
  • 89.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TOMM22 35
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 80 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
chicken
(Gallus gallus)
Aves TOMM22 35
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TOMM22 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tomm22 34
  • 66.67 (n)
Str.6735 34
zebrafish
(Danio rerio)
Actinopterygii tomm22 35
  • 65 (a)
OneToOne
wufa02g11 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7281 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005376 34
  • 53.61 (n)
fruit fly
(Drosophila melanogaster)
Insecta mge 34 35
  • 52.98 (n)
worm
(Caenorhabditis elegans)
Secernentea tomm-22 35
  • 34 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
OneToOne
Species where no ortholog for TOMM22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TOMM22 Gene

ENSEMBL:
Gene Tree for TOMM22 (if available)
TreeFam:
Gene Tree for TOMM22 (if available)

Paralogs for TOMM22 Gene

(1) SIMAP similar genes for TOMM22 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TOMM22: view

No data available for Paralogs for TOMM22 Gene

Variants for TOMM22 Gene

Sequence variations from dbSNP and Humsavar for TOMM22 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1056610 -- 38,684,073(+) GCAGA(C/T)GGTTA utr-variant-3-prime
rs1056631 -- 38,684,218(+) ttttt(A/T)aaaGA utr-variant-3-prime
rs1056661 -- 38,684,240(+) GGGGC(A/G)GGACA utr-variant-3-prime
rs1056691 -- 38,684,355(+) CAGAA(G/T)GGGGA utr-variant-3-prime
rs112928978 -- 38,680,133(+) AAAAT(-/A)CAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TOMM22 Gene

Variant ID Type Subtype PubMed ID
nsv508733 CNV insertion 20534489

Variation tolerance for TOMM22 Gene

Residual Variation Intolerance Score: 42.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TOMM22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TOMM22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOMM22 Gene

Disorders for TOMM22 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TOMM22 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spinocerebellar ataxia 12
  • spinocerebellar ataxia type 12
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TOMM22

Genetic Association Database (GAD)
TOMM22
Human Genome Epidemiology (HuGE) Navigator
TOMM22
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TOMM22
genes like me logo Genes that share disorders with TOMM22: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TOMM22 Gene

Publications for TOMM22 Gene

  1. Identification and functional analysis of human Tom22 for protein import into mitochondria. (PMID: 10982837) Yano M. … Mori M. (Mol. Cell. Biol. 2000) 2 3 4 22 64
  2. Identification of mammalian Tom22 as a subunit of the preprotein translocase of the mitochondrial outer membrane. (PMID: 10900208) Saeki K. … Mihara K. (J. Biol. Chem. 2000) 2 3 4 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. (PMID: 18331822) Kato H. … Mihara K. (Biochem. Biophys. Res. Commun. 2008) 4 22 64
  5. TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax. (PMID: 17096026) Bellot G. … Vallette F.M. (Cell Death Differ. 2007) 3 22 64

Products for TOMM22 Gene

Sources for TOMM22 Gene

Content
Loading form....