TOMM22 Gene
protein-coding GIFtS: 53
GCID: GC22P039077
|
|
translocase of outer mitochondrial membrane 22 homolog (yeast)
| |
Aliases
for TOMM22 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Translocase Of Outer Mitochondrial Membrane 22 Homolog (Yeast)1 2 | | MSTP0652 | | TOM221 2 3 5 | | Mitochondrial Import Receptor Subunit TOM22 Homolog2 | | Translocase Of Outer Membrane 22 KDa Subunit Homolog2 3 | | Mitochondrial Import Receptor Tom222 | | 1C9-22 3 | | HTom221 | | MST0652 | | |
Export aliases for TOMM22 gene to outside databasesPrevious GC identifers: GC22P035692 GC22P037321 GC22P037402 GC22P022044 |
Summaries
for TOMM22 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TOMM22:
The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encodedprotein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolicpreproteins into the mitochondrion. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TOM22_HUMAN, Q9NS69Function: Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsiblefor the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with theperipheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins intothe translocation pore
Gene Wiki entry for TOMM22
|
Genomic Views
for TOMM22 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TOMM22 gene promoter:
SRY AML1a POU2F1 POU2F1a FOXD1 Nkx2-5
Other transcription factors
Search SABiosciences Chromatin IP Primers for TOMM22
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOMM22 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q12-q13 Ensembl cytogenetic band: 22q13.1 HGNC cytogenetic band: 22q12-q13TOMM22 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P039077: view genomic region
(about GC identifiers)
Start:
|
39,077,953 bp from pter |
End:
|
39,080,818 bp from pter |
Size:
|
2,866 bases |
Orientation:
|
plus strand |
|
Proteins
for TOMM22 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TOM22_HUMAN, Q9NS69 (See
protein sequence)Recommended Name: Mitochondrial import receptor subunit TOM22 homolog Size: 142 amino acids; 15522 Da
Subunit: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) whichconsists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts withTOMM40. Interacts with PPP2R2B (By similarity)
Subcellular location: Mitochondrion outer membrane; Single-pass membrane protein (By similarity)Explore the universe of human proteins at neXtProt for TOMM22: NX_Q9NS69
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NS69
TOMM22 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_064628.1
ENSEMBL proteins: ENSP00000216034 Reactome Protein details: Q9NS69
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
TOMM22 for ontologies About GeneDecksing
TOMM22 Antibody Products:
Assay Products for TOMM22: |
Protein
Domains /
Families
for TOMM22 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TOMM22 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NS69ProtoNet protein and cluster: Q9NS69 UniProtKB/Swiss-Prot: TOM22_HUMAN, Q9NS69Domain: Requires the transmembrane domain (TMD), a short segment (the import sequence) in the cytoplasmic domainlocalizing separately from the TMD and the C-tail signal in the C-terminal domain for efficient targeting andintegration into the TOM complex (By similarity). The N-terminal domain (residues 1-62) is important for binding tothe unfolded mature imported proteins. Residues (49-71) of the cytoplasmic domain interacts with TOMM20 while theC-terminal segment (residues 63-82) binds presequence of preproteinsSimilarity: Belongs to the Tom22 family |
Function
for TOMM22 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TOM22_HUMAN, Q9NS69Function: Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsiblefor the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with theperipheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins intothe translocation pore
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM22
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM22 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
TOMM22 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for TOMM22:
|
Pathways & Interactions
for TOMM22 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Mitochondrial Protein Import | | | 2 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for TOMM22
TOMM22 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TOMM22
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/39 Interacting proteins for TOMM22 (Q9NS691, 3 ENSP000002160344) via UniProtKB, MINT, STRING, and/or I2D (see all 39)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006626 | protein targeting to mitochondrion |
TAS | -- | | GO:0044267 | cellular protein metabolic process |
TAS | -- | | GO:0045040 | protein import into mitochondrial outer membrane |
IDA | 15644312 |
TOMM22 for ontologies About GeneDecksing
|
Drugs & Compounds
for TOMM22 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TOMM22
Search CenterWatch for drugs/clinical trials and news about TOMM22 / TOM22
|
Transcripts
for TOMM22 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TOMM22 gene: NM_020243.4 Unigene Cluster for TOMM22: Translocase of outer mitochondrial membrane 22 homolog (yeast) Hs.595072 [show with all ESTs]Unigene Representative Sequence: NM_0202432 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000216034(uc003awe.3) ENST00000492561
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM22 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM22
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TOMM22 (NM_020243) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TOMM22 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM22 |
Additional cDNA sequence: AB040119.1 AB041906.1 AF163256.1 AK024731.1 AK223021.1 AK312076.1 BC009363.2 CR456475.1 14 DOTS entries: DT.100819731 DT.87016592 DT.447534 DT.120652130 DT.95364346 DT.100036926 DT.95206319 DT.95306022 DT.91767780 DT.120652076 DT.120652080 DT.120652132 DT.87012395 DT.91818530 24/515 AceView cDNA sequences (see all 515): AL050345 CR619995 AW874604 AA733214 CA432856 CD626926 AU099418 AA877750 CR610817 H55702 BU580575 BQ961547 AW372438 BU633560 AW015368 BM458890 BX391149 AI091474 AI122822 BM831784 BU553560 NM_015373 CD672638 BU189351
GeneLoc Exon Structure
|
Expression
for TOMM22 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TOMM22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACACAATGT
About this image
See TOMM22 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TOMM22
SOURCE GeneReport for Unigene cluster: Hs.595072
UniProtKB/Swiss-Prot: TOM22_HUMAN, Q9NS69Tissue specificity: Ubiquitous
SABiosciences Expression via Pathway-Focused PCR Array including TOMM22:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOMM22
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TOMM22 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOMM22 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOMM22 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM22 |
Orthologs
for TOMM22 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TOMM22 gene from 7/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Tomm221 , 5 |
translocase of outer mitochondrial membrane 22 homolog more1, 5 |
89.44(n)1
94.37(a)1 |
|
15 (37.85 cM)5
2236961 NM_172609.31 NP_766197.21
796708615 |
chicken
(Gallus gallus) |
Aves |
TOMM221 |
translocase of outer mitochondrial membrane 22 homolog more |
76.29(n)
83.8(a) |
|
770933 XM_001234245.2 XP_001234246.1 |
lizard
(Anolis carolinensis) |
Reptilia |
TOMM226 |
-- |
77(a) |
1 ↔ 1 |
5(24144229-24155131) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.67352 |
Transcribed sequence with weak similarity to protein more |
73.2(n) |
|
142016441 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufa02g112 |
Danio rerio, clone IMAGE5410294, mRNA |
72.7(n) |
|
BC047825.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
mge1 |
maggie |
51.52(n)
43.94(a) |
|
38459 NM_079186.3 NP_523910.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
tomm-226 |
Protein TOMM-22 |
34(a) |
1 ↔ 1 |
II(468370-470482) |
ENSEMBL Gene Tree for TOMM22 (if available)
TreeFam Gene Tree for TOMM22 (if available) |
Paralogs
for TOMM22 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TOMM22 gene
1 SIMAP similar gene for TOMM22 using alignment to 1 protein entry: TOM22_HUMAN:MST065
TOMM22 for paralogs About GeneDecksing
5/7 Pseudogenes.org Pseudogenes for TOMM22 (see all 7)
PGOHUM00000238936 PGOHUM00000242398 PGOHUM00000248357 PGOHUM00000237847 PGOHUM00000246123
|
Genomic Variants
for TOMM22 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TOMM22 (39077953 - 39080818 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TOMM22: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOMM22 |
|
Disorders
/ Diseases
for TOMM22 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TOMM22 for disorders About GeneDecksing
OMIM gene information: 607046
OMIM disorders: --
2  diseases for TOMM22: About MalaCardsintrahepatic cholangiocarcinoma cholangiocarcinoma
Human Genome Epidemiology (HuGE) Navigator: TOMM22 (1 document)
Export disorders for TOMM22 gene to outside databases
|
Publications
for TOMM22 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TOMM22 gene, integrated from 9 sources (see all 44):
(articles sorted by number of sources associating them with TOMM22) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and functional analysis of human Tom22 for protein import into mitochondria. (PubMed id 10982837)1, 2, 3, 9 Yano M.... Mori M. (2000)
- Identification of mammalian Tom22 as a subunit of the preprotein translocase of the mitochondrial outer membrane. (PubMed id 10900208)1, 2, 3 Saeki K....Mihara K. (2000)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax. (PubMed id 17096026)1, 9 Bellot G....Vallette F.M. (2007)
- Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity. (PubMed id 14699115)1, 9 Yano M....Mori M. (2004)
- Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane. (PubMed id 12198123)1, 9 Johnston A.J.... Ryan M.T. (2002)
- Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. (PubMed id 18331822)2, 9 Kato H. and Mihara K. (2008)
|
External Searches for TOMM22 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TOMM22 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TOMM22 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TOMM22 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TOMM22 gene:
Search GeneIP for patents involving TOMM22
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TOMM22 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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