Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TOMM22 Gene

Aliases for TOMM22 Gene

  • Translocase Of Outer Mitochondrial Membrane 22 Homolog (Yeast) 2 3
  • TOM22 3 4 6
  • Translocase Of Outer Membrane 22 KDa Subunit Homolog 3 4
  • 1C9-2 3 4
  • Mitochondrial Import Receptor Subunit TOM22 Homolog 3
  • Mitochondrial Import Receptor Tom22 3
  • MSTP065 3
  • MST065 3
  • HTom22 4

External Ids for TOMM22 Gene

Summaries for TOMM22 Gene

Entrez Gene Summary for TOMM22 Gene

  • The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion. [provided by RefSeq, Jul 2008]

GeneCards Summary for TOMM22 Gene

TOMM22 (Translocase Of Outer Mitochondrial Membrane 22 Homolog (Yeast)) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Mitochondrial Protein Import. GO annotations related to this gene include protein transmembrane transporter activity.

UniProtKB/Swiss-Prot for TOMM22 Gene

  • Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore.

Gene Wiki entry for TOMM22 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOMM22 Gene

Genomics for TOMM22 Gene

Genomic Location for TOMM22 Gene

Start:
38,681,948 bp from pter
End:
38,685,421 bp from pter
Size:
3,474 bases
Orientation:
Plus strand

Genomic View for TOMM22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TOMM22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOMM22 Gene

Regulatory Elements for TOMM22 Gene

Proteins for TOMM22 Gene

  • Protein details for TOMM22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS69-TOM22_HUMAN
    Recommended name:
    Mitochondrial import receptor subunit TOM22 homolog
    Protein Accession:
    Q9NS69
    Secondary Accessions:

    Protein attributes for TOMM22 Gene

    Size:
    142 amino acids
    Molecular mass:
    15522 Da
    Quaternary structure:
    • Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with TOMM40. Interacts with PPP2R2B (By similarity).

neXtProt entry for TOMM22 Gene

Proteomics data for TOMM22 Gene at MOPED

Post-translational modifications for TOMM22 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys141

Other Protein References for TOMM22 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TOMM22 Gene

Domains for TOMM22 Gene

Protein Domains for TOMM22 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TOM22_HUMAN
Domain:
  • Requires the transmembrane domain (TMD), a short segment (the import sequence) in the cytoplasmic domain localizing separately from the TMD and the C-tail signal in the C-terminal domain for efficient targeting and integration into the TOM complex (By similarity). The N-terminal domain (residues 1-62) is important for binding to the unfolded mature imported proteins. Residues (49-71) of the cytoplasmic domain interacts with TOMM20 while the C-terminal segment (residues 63-82) binds presequence of preproteins.:
    • Q9NS69
Family:
  • Belongs to the Tom22 family.:
    • Q9NS69
genes like me logo Genes that share domains with TOMM22: view

No data available for Gene Families for TOMM22 Gene

Function for TOMM22 Gene

Molecular function for TOMM22 Gene

UniProtKB/Swiss-Prot Function: Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore.

Gene Ontology (GO) - Molecular Function for TOMM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12198123
GO:0008320 protein transmembrane transporter activity TAS 15644312
genes like me logo Genes that share ontologies with TOMM22: view
genes like me logo Genes that share phenotypes with TOMM22: view

miRNA for TOMM22 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TOMM22 Gene

Localization for TOMM22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOMM22 Gene

Mitochondrion outer membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TOMM22 Gene COMPARTMENTS Subcellular localization image for TOMM22 gene
Compartment Confidence
mitochondrion 5
cytosol 3
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TOMM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005741 mitochondrial outer membrane --
GO:0005742 mitochondrial outer membrane translocase complex IDA 12198123
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with TOMM22: view

Pathways for TOMM22 Gene

genes like me logo Genes that share pathways with TOMM22: view

Pathways by source for TOMM22 Gene

2 Reactome pathways for TOMM22 Gene

Gene Ontology (GO) - Biological Process for TOMM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion TAS 14557246
GO:0006886 intracellular protein transport --
GO:0044267 cellular protein metabolic process TAS --
GO:0045040 protein import into mitochondrial outer membrane IDA 15644312
genes like me logo Genes that share ontologies with TOMM22: view

Transcripts for TOMM22 Gene

mRNA/cDNA for TOMM22 Gene

Unigene Clusters for TOMM22 Gene

Translocase of outer mitochondrial membrane 22 homolog (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TOMM22 Gene

No ASD Table

Relevant External Links for TOMM22 Gene

GeneLoc Exon Structure for
TOMM22
ECgene alternative splicing isoforms for
TOMM22

Expression for TOMM22 Gene

mRNA expression in normal human tissues for TOMM22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TOMM22 Gene

SOURCE GeneReport for Unigene cluster for TOMM22 Gene Hs.595072

mRNA Expression by UniProt/SwissProt for TOMM22 Gene

Q9NS69-TOM22_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with TOMM22: view

Orthologs for TOMM22 Gene

This gene was present in the common ancestor of animals.

Orthologs for TOMM22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOMM22 36
  • 100 (n)
  • 100 (a)
TOMM22 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TOMM22 36
  • 91.93 (n)
  • 98.44 (a)
TOMM22 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 95 (a)
OneToMany
-- 37
  • 90 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tomm22 36
  • 89.57 (n)
  • 93.89 (a)
Tomm22 16
Tomm22 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 52 (a)
OneToMany
-- 37
  • 80 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TOMM22 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tomm22 36
  • 89.06 (n)
  • 93.13 (a)
chicken
(Gallus gallus)
Aves TOMM22 37
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TOMM22 37
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6735 36
tomm22 36
  • 66.67 (n)
  • 74.8 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7281 36
zebrafish
(Danio rerio)
Actinopterygii tomm22 37
  • 65 (a)
OneToOne
wufa02g11 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005376 36
  • 53.61 (n)
  • 51.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta mge 36
  • 52.98 (n)
  • 52.63 (a)
mge 37
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tomm-22 37
  • 34 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 53 (a)
OneToOne
Species with no ortholog for TOMM22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TOMM22 Gene

ENSEMBL:
Gene Tree for TOMM22 (if available)
TreeFam:
Gene Tree for TOMM22 (if available)

Paralogs for TOMM22 Gene

Selected SIMAP similar genes for TOMM22 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TOMM22: view

No data available for Paralogs for TOMM22 Gene

Variants for TOMM22 Gene

Sequence variations from dbSNP and Humsavar for TOMM22 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs14570 -- 38,684,389(-) TGCAG(A/G)GGAAA utr-variant-3-prime
rs1056610 -- 38,684,073(+) GCAGA(C/T)GGTTA utr-variant-3-prime
rs1056631 -- 38,684,218(+) ttttt(A/T)aaaGA utr-variant-3-prime
rs1056661 -- 38,684,240(+) GGGGC(A/G)GGACA utr-variant-3-prime
rs1056691 -- 38,684,355(+) CAGAA(G/T)GGGGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TOMM22 Gene

Variant ID Type Subtype PubMed ID
nsv508733 CNV Insertion 20534489
nsv915067 CNV Loss 21882294

Relevant External Links for TOMM22 Gene

HapMap Linkage Disequilibrium report
TOMM22

Disorders for TOMM22 Gene

Relevant External Links for TOMM22

Genetic Association Database (GAD)
TOMM22
Human Genome Epidemiology (HuGE) Navigator
TOMM22
genes like me logo Genes that share disorders with TOMM22: view

No data available for UniProtKB/Swiss-Prot for TOMM22 Gene

Publications for TOMM22 Gene

  1. Identification and functional analysis of human Tom22 for protein import into mitochondria. (PMID: 10982837) Yano M. … Mori M. (Mol. Cell. Biol. 2000) 2 3 4 23
  2. Identification of mammalian Tom22 as a subunit of the preprotein translocase of the mitochondrial outer membrane. (PMID: 10900208) Saeki K. … Mihara K. (J. Biol. Chem. 2000) 2 3 4
  3. Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity. (PMID: 14699115) Yano M. … Mori M. (J. Biol. Chem. 2004) 3 23
  4. TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax. (PMID: 17096026) Bellot G. … Vallette F.M. (Cell Death Differ. 2007) 3 23
  5. Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane. (PMID: 12198123) Johnston A.J. … Ryan M.T. (J. Biol. Chem. 2002) 3 23

Products for TOMM22 Gene

Sources for TOMM22 Gene

Back to Top

Content