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TOMM20L Gene

protein-coding   GIFtS: 39
GCID: GC14P058862

Translocase Of Outer Mitochondrial Membrane 20 Homolog (Yeast)-Like

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Translocase Of Outer Mitochondrial Membrane 20 Homolog (Yeast)-Like1 2
Translocase Of Outer Mitochondrial Membrane 20 Homolog Type I1 2
UNQ94382
TOMM20-Like Protein 12

External Ids:    HGNC: 337521   Entrez Gene: 3879902   Ensembl: ENSG000001968607   UniProtKB: Q6UXN73   

Export aliases for TOMM20L gene to outside databases

Previous GC identifers: GC14P057933 GC14P039027


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TOMM20L Gene:
TOMM20L (translocase of outer mitochondrial membrane 20 homolog (yeast)-like) is a protein-coding gene. An important paralog of this gene is TOMM20.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the TOMM20L gene promoter:
         Sox5   p53   HNF-4alpha2   LUN-1   Nkx2-5   POU6F1 (c2)   HNF-4alpha1   AREB6   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTOMM20L promoter sequence
   Search Chromatin IP Primers for TOMM20L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TOMM20L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.1   Ensembl cytogenetic band:  14q23.1   HGNC cytogenetic band: 14q23.1

TOMM20L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOMM20L gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P058862:  view genomic region     (about GC identifiers)

Start:
58,862,634 bp from pter      End:
58,875,419 bp from pter
Size:
12,786 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB/Swiss-Prot: TO20L_HUMAN, Q6UXN7 (See protein sequence)
Recommended Name: TOMM20-like protein 1  
Size: 152 amino acids; 17700 Da
Secondary accessions: B2RPR0

Explore the universe of human proteins at neXtProt for TOMM20L: NX_Q6UXN7

Explore proteomics data for TOMM20L at MOPED


See TOMM20L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_997260.1  
ENSEMBL proteins: 
 ENSP00000354204   ENSP00000451683  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:
 IPR022422 MAS20_rcpt_metazoan
 IPR023392 Tom20_dom
 IPR002056 MAS20_rcpt-related

Graphical View of Domain Structure for InterPro Entry Q6UXN7

ProtoNet protein and cluster: Q6UXN7

1 Blocks protein domain: IPB002056 MAS20 protein import receptor signature

UniProtKB/Swiss-Prot: TO20L_HUMAN, Q6UXN7
Similarity: Belongs to the Tom20 family


Find genes that share domains with TOMM20L           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     1 MGI phenotypic allele for Tomm20l (no phenotypes)

Find genes that share phenotypes with TOMM20L           About GenesLikeMe

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TOMM20L
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SwitchGear 3'UTR luciferase reporter plasmidTOMM20L 3' UTR sequence
Inhib. RNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TO20L_HUMAN, Q6UXN7: Mitochondrion outer membrane; Single-pass membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion5
cytosol1
extracellular1
golgi apparatus1
plasma membrane1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005742mitochondrial outer membrane translocase complex IEA--
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with TOMM20L           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TOMM20L
Interactions:

    Search GeneGlobe Interaction Network for TOMM20L

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

Selected Interacting proteins for TOMM20L (ENSP000003542044) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
InteractantInteraction Details
GeneCardExternal ID(s)
TOMM7ENSP000003512144STRING: ENSP00000351214
PEX19ENSP000003570514STRING: ENSP00000357051
TOMM40ENSP000002524874STRING: ENSP00000252487
TOMM40LENSP000003569664STRING: ENSP00000356966
TOMM70AENSP000002843204STRING: ENSP00000284320
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Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006605protein targeting IEA--
GO:0006886intracellular protein transport ----

Find genes that share ontologies with TOMM20L           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TOMM20L (TO20L)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TOMM20L gene: 
NM_207377.2  

Unigene Cluster for TOMM20L:

Translocase of outer mitochondrial membrane 20 homolog (yeast)-like
Hs.592307  [show with all ESTs]
Unigene Representative Sequence: AY358266
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000360945(uc001xdr.1 uc010trq.1) ENST00000557754
miRNA
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hsa-miR-3688-3p hsa-miR-522 hsa-miR-224*
SwitchGear 3'UTR luciferase reporter plasmidTOMM20L 3' UTR sequence
Inhib. RNA
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  QuantiFast Probe-based Assays in human, mouse, rat TOMM20L

Additional mRNA sequence: 

AY358266.1 BC137557.1 BC137563.1 BC144709.1 

2 DOTS entries:

DT.101968142  DT.317242 

8 AceView cDNA sequences:

AA419058 NM_207377 AY358266 BX093255 H82628 AA730780 AA641594 R26004 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TOMM20L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AATGAACAGG
TOMM20L Expression
About this image

TOMM20L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TOMM20L Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.592307
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for TOMM20L gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tomm20l1 , 5 translocase of outer mitochondrial membrane 20 homolog more1, 5 71.05(n)1
60.53(a)1
  12 (29.39 cM)5
752661  NM_029227.11  NP_083503.11 
 711114285 
lizard
(Anolis carolinensis)
Reptilia TOMM20L6
translocase of outer mitochondrial membrane 20 hom...
38(a)
1 ↔ 1
GL343459.1(399509-411346)
fruit fly
(Drosophila melanogaster)
Insecta tomboy206
Tom206
Translocase of outer membrane 20
26(a)
26(a)
many ↔ many
many ↔ many
3R(6561068-6561679)
3L(19993744-19995546)
worm
(Caenorhabditis elegans)
Secernentea tomm-206
Protein TOMM-20 (tomm-20) mRNA, complete cds
25(a)
1 → many
V(12342310-12343469) WBGene00009092


ENSEMBL Gene Tree for TOMM20L (if available)
TreeFam Gene Tree for TOMM20L (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TOMM20L gene
TOMM202  
1 SIMAP similar gene for TOMM20L using alignment to 2 protein entries:     TO20L_HUMAN (see all proteins):
TOMM20

Find genes that share paralogs with TOMM20L           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TOMM20L (see all 242)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1181509871,2
C,F--58860687(+) GCTGAC/TACTAT 1 -- us2k11Minor allele frequency- T:0.02NA 120
rs80038411,2
C,F,H--58860893(+) CCtatC/Atatct 1 -- us2k113Minor allele frequency- A:0.48NS EA NA 1970
rs124315131,2
C,A,H--58860897(+) TCTATA/CTCTAT 1 -- us2k13Minor allele frequency- C:0.00NA 6
rs80038451,2
C,H--58860899(+) tatctA/Ctatat 1 -- us2k13Minor allele frequency- C:0.00NA 6
rs714214531,2
C--58860925(+) TATTTT/ATTTTT 1 -- us2k12Minor allele frequency- A:0.00NA 4
rs1891014751,2
--58861024(+) CTCCCC/TGCCTC 1 -- us2k10--------
rs1818319321,2
--58861406(+) TTTATC/TGAGAC 1 -- us2k10--------
rs71460351,2
C,H--58861450(+) gtgacG/Acaatc 1 -- us2k19Minor allele frequency- A:0.00NA WA CSA 16
rs1873249481,2
C--58861474(+) ACCTCC/TGCCTC 1 -- us2k10--------
rs1420893841,2
--58861655(+) GCTGGC/GATTAC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for TOMM20L (58862634 - 58875419 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for TOMM20L:    About this table    
Variant IDTypeSubtypePubMed ID
esv2748733CNV Deletion23290073
nsv901985CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TOMM20L gene integrated from 10 sources:
(articles sorted by number of sources associating them with TOMM20L)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20. (PubMed id 15733919)1, 3 LikiA8 V.A....Lithgow T. (J. Mol. Biol. 2005)
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
  3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 387990 HGNC: 33752 AceView: UNQ9438 Ensembl:ENSG00000196860 euGenes: HUgn387990
ECgene: TOMM20L H-InvDB: TOMM20L

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TOMM20L Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TOMM20L gene:
Search GeneIP for patents involving TOMM20L

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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