TOMM20L Gene
protein-coding GIFtS: 37
GCID: GC14P058862
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translocase of outer mitochondrial membrane 20 homolog (yeast)-like
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Aliases
for TOMM20L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Translocase Of Outer Mitochondrial Membrane 20 Homolog (Yeast)-Like1 2 | | UNQ94381 2 | | TOMM20-Like Protein 12 | | Translocase Of Outer Mitochondrial Membrane 20 Homolog Type I2 |
Export aliases for TOMM20L gene to outside databasesPrevious GC identifers: GC14P057933 GC14P039027 |
Summaries
for TOMM20L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TOMM20L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TOMM20L gene promoter:
Sox5 p53 HNF-4alpha2 LUN-1 Nkx2-5 POU6F1 (c2) HNF-4alpha1 AREB6 FOXJ2 (long isoform) FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TOMM20L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOMM20L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q23.1 Ensembl cytogenetic band: 14q23.1 HGNC cytogenetic band: 14q23.1TOMM20L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P058862: view genomic region
(about GC identifiers)
Start:
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58,862,634 bp from pter |
End:
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58,875,419 bp from pter |
Size:
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12,786 bases |
Orientation:
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plus strand |
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Proteins
for TOMM20L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TO20L_HUMAN, Q6UXN7 (See
protein sequence)Recommended Name: TOMM20-like protein 1 Size: 152 amino acids; 17700 Da
Subcellular location: Mitochondrion outer membrane; Single-pass membrane protein (Potential)
Secondary accessions: B2RPR0Explore the universe of human proteins at neXtProt for TOMM20L: NX_Q6UXN7
TOMM20L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_997260.1
ENSEMBL proteins: ENSP00000354204 ENSP00000451683
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005742 | mitochondrial outer membrane translocase complex |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TOMM20L for ontologies About GeneDecksing
TOMM20L Antibody Products:
Assay Products for TOMM20L: |
Protein
Domains /
Families
for TOMM20L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TOMM20L for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6UXN7ProtoNet protein and cluster: Q6UXN7 1 Blocks protein family: IPB002056 MAS20 protein import receptor signature
UniProtKB/Swiss-Prot: TO20L_HUMAN, Q6UXN7Similarity: Belongs to the Tom20 family |
Function
for TOMM20L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM20L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM20L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TOMM20L (NM_207377) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TOMM20L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM20L |
|
Pathways & Interactions
for TOMM20L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TOMM20L
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/6 Interacting proteins for TOMM20L (ENSP000003542044) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006605 | protein targeting |
IEA | -- |
TOMM20L for ontologies About GeneDecksing
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Drugs & Compounds
for TOMM20L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TOMM20L
Search CenterWatch for drugs/clinical trials and news about TOMM20L / TO20L
|
Transcripts
for TOMM20L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TOMM20L gene: NM_207377.2 Unigene Cluster for TOMM20L: Translocase of outer mitochondrial membrane 20 homolog (yeast)-like Hs.592307 [show with all ESTs]Unigene Representative Sequence: AY3582662 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000360945(uc001xdr.1 uc010trq.1) ENST00000557754
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM20L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM20L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TOMM20L (NM_207377) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TOMM20L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM20L |
Additional cDNA sequence: AY358266.1 BC137557.1 BC137563.1 BC144709.1 2 DOTS entries: DT.101968142 DT.317242 8 AceView cDNA sequences: AA419058 NM_207377 BX093255 AY358266 H82628 AA730780 AA641594 R26004
GeneLoc Exon Structure
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Expression
for TOMM20L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TOMM20L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGAACAGG
About this image
See TOMM20L Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.592307
SABiosciences Custom PCR Arrays for TOMM20L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOMM20L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TOMM20L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOMM20L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOMM20L |
Orthologs
for TOMM20L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TOMM20L gene from 4/15 species (see all 15) About this table
ENSEMBL Gene Tree for TOMM20L (if available)
TreeFam Gene Tree for TOMM20L (if available) |
Paralogs
for TOMM20L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TOMM20L gene
- TOMM202
1 SIMAP similar gene for TOMM20L using alignment to 2 protein entries: TO20L_HUMAN (see all proteins):TOMM20
TOMM20L for paralogs About GeneDecksing
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Genomic Variants
for TOMM20L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TOMM20L (58862634 - 58875419 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TOMM20L: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOMM20L |
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Disorders
/ Diseases
for TOMM20L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TOMM20L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TOMM20L gene integrated from 9 sources:
(articles sorted by number of sources associating them with TOMM20L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20. (PubMed id 15733919)1, 3 Likic V.A....Lithgow T. (2005)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TOMM20L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TOMM20L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TOMM20L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TOMM20L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TOMM20L | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for TOMM20L gene:
Search GeneIP for patents involving TOMM20L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TOMM20L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TOMM20L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TOMM20L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOMM20L | | | OriGene Protein Over-expression Lysate for TOMM20L | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TOMM20L | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM20L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM20L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TOMM20L | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TOMM20L | | OriGene Custom Protein Services for TOMM20L | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TOMM20L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOMM20L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOMM20L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOMM20L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOMM20L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOMM20L |
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 | | | TOMM20L Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for TOMM20L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM20L |
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