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Aliases for TOMM20L Gene

Aliases for TOMM20L Gene

  • Translocase Of Outer Mitochondrial Membrane 20 Like 2 3 5
  • Translocase Of Outer Mitochondrial Membrane 20 Homolog Type I 2 3
  • Translocase Of Outer Mitochondrial Membrane 20 Homolog (Yeast)-Like 2
  • Translocase Of Outer Mitochondrial Membrane 20 Homolog-Like 3
  • TOMM20-Like Protein 1 3
  • UNQ9438 3

External Ids for TOMM20L Gene

Previous GeneCards Identifiers for TOMM20L Gene

  • GC14P057933
  • GC14P058862
  • GC14P039027

Summaries for TOMM20L Gene

GeneCards Summary for TOMM20L Gene

TOMM20L (Translocase Of Outer Mitochondrial Membrane 20 Like) is a Protein Coding gene. An important paralog of this gene is TOMM20.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOMM20L Gene

Genomics for TOMM20L Gene

Regulatory Elements for TOMM20L Gene

Enhancers for TOMM20L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G058280 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -114.2 -114163 2.4 PKNOX1 ATF1 FEZF1 YY1 TCF12 ZNF766 ELK1 FOS ZNF263 JUNB ACTR10 TOMM20L ENSG00000258682 ARID4A HMGB1P14 PIR55001
GH14G058296 1.7 FANTOM5 ENCODE dbSUPER 10.8 -97.5 -97479 4.4 PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 TOMM20L PSMA3-AS1 ARID4A ACTR10 GC14P058345
GH14G058329 1.2 Ensembl ENCODE 10.3 -65.0 -64956 1.9 HDGF PKNOX1 NFIB SIN3A BMI1 ZBTB40 RAD21 YY1 ZNF766 ZNF366 PSMA3-AS1 ENSG00000258682 TOMM20L GC14P058345 ARID4A
GH14G058104 0.8 ENCODE 10.3 -291.0 -290959 0.2 FOXA2 NFIB ZBTB21 JUN FEZF1 SALL2 CTBP1 GATA3 ZNF366 KLF8 ENSG00000259969 TOMM20L RPL31P4 LOC440181 GC14M058071 GC14P058110
GH14G058274 0.7 ENCODE dbSUPER 11.1 -120.5 -120471 1.9 POLR2A DPF2 PRDM1 TOMM20L PIR55001 HMGB1P14
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TOMM20L on UCSC Golden Path with GeneCards custom track

Promoters for TOMM20L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000069045 184 1001 HDGF FOXA2 ARID4B SIN3A DMAP1 ELK1 ZNF143 ZNF207 ZNF263 MXD4

Genomic Location for TOMM20L Gene

Chromosome:
14
Start:
58,395,916 bp from pter
End:
58,417,080 bp from pter
Size:
21,165 bases
Orientation:
Plus strand

Genomic View for TOMM20L Gene

Genes around TOMM20L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOMM20L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOMM20L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOMM20L Gene

Proteins for TOMM20L Gene

  • Protein details for TOMM20L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXN7-TO20L_HUMAN
    Recommended name:
    TOMM20-like protein 1
    Protein Accession:
    Q6UXN7
    Secondary Accessions:
    • B2RPR0

    Protein attributes for TOMM20L Gene

    Size:
    152 amino acids
    Molecular mass:
    17700 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TOMM20L Gene

Post-translational modifications for TOMM20L Gene

No Post-translational modifications

Other Protein References for TOMM20L Gene

No data available for DME Specific Peptides for TOMM20L Gene

Domains & Families for TOMM20L Gene

Protein Domains for TOMM20L Gene

Suggested Antigen Peptide Sequences for TOMM20L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UXN7

UniProtKB/Swiss-Prot:

TO20L_HUMAN :
  • Belongs to the Tom20 family.
Family:
  • Belongs to the Tom20 family.
genes like me logo Genes that share domains with TOMM20L: view

No data available for Gene Families for TOMM20L Gene

Function for TOMM20L Gene

Gene Ontology (GO) - Molecular Function for TOMM20L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015266 contributes_to protein channel activity IBA --
GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity IBA --
GO:0030943 mitochondrion targeting sequence binding IBA --
genes like me logo Genes that share ontologies with TOMM20L: view

Phenotypes for TOMM20L Gene

MGI mutant phenotypes for TOMM20L:
inferred from 1 alleles
GenomeRNAi human phenotypes for TOMM20L:
genes like me logo Genes that share phenotypes with TOMM20L: view

Animal Models for TOMM20L Gene

MGI Knock Outs for TOMM20L:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TOMM20L Gene

Localization for TOMM20L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOMM20L Gene

Mitochondrion outer membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TOMM20L gene
Compartment Confidence
mitochondrion 4
plasma membrane 1
extracellular 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TOMM20L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IEA --
GO:0005742 mitochondrial outer membrane translocase complex IBA,IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031307 integral component of mitochondrial outer membrane IBA --
genes like me logo Genes that share ontologies with TOMM20L: view

Pathways & Interactions for TOMM20L Gene

SuperPathways for TOMM20L Gene

No Data Available

Gene Ontology (GO) - Biological Process for TOMM20L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting IEA --
GO:0006886 intracellular protein transport IEA --
GO:0016031 tRNA import into mitochondrion IBA --
GO:0030150 protein import into mitochondrial matrix IBA --
GO:0070096 mitochondrial outer membrane translocase complex assembly IBA --
genes like me logo Genes that share ontologies with TOMM20L: view

No data available for Pathways by source and SIGNOR curated interactions for TOMM20L Gene

Drugs & Compounds for TOMM20L Gene

No Compound Related Data Available

Transcripts for TOMM20L Gene

mRNA/cDNA for TOMM20L Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TOMM20L Gene

Translocase of outer mitochondrial membrane 20 homolog (yeast)-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOMM20L Gene

No ASD Table

Relevant External Links for TOMM20L Gene

GeneLoc Exon Structure for
TOMM20L
ECgene alternative splicing isoforms for
TOMM20L

Expression for TOMM20L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TOMM20L Gene

mRNA differential expression in normal tissues according to GTEx for TOMM20L Gene

This gene is overexpressed in Testis (x28.4).

NURSA nuclear receptor signaling pathways regulating expression of TOMM20L Gene:

TOMM20L

SOURCE GeneReport for Unigene cluster for TOMM20L Gene:

Hs.592307
genes like me logo Genes that share expression patterns with TOMM20L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TOMM20L Gene

Orthologs for TOMM20L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TOMM20L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOMM20L 34 35
  • 99.34 (n)
cow
(Bos Taurus)
Mammalia TOMM20L 34
  • 87.25 (n)
-- 35
  • 37 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia TOMM20L 34 35
  • 83.77 (n)
rat
(Rattus norvegicus)
Mammalia Tomm20l 34
  • 74.05 (n)
mouse
(Mus musculus)
Mammalia Tomm20l 34 16 35
  • 71.05 (n)
oppossum
(Monodelphis domestica)
Mammalia TOMM20L 35
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TOMM20L 35
  • 38 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tom20 35
  • 26 (a)
ManyToMany
tomboy20 35
  • 26 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea tomm-20 35
  • 25 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOM20 37
Species where no ortholog for TOMM20L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TOMM20L Gene

ENSEMBL:
Gene Tree for TOMM20L (if available)
TreeFam:
Gene Tree for TOMM20L (if available)

Paralogs for TOMM20L Gene

Paralogs for TOMM20L Gene

(1) SIMAP similar genes for TOMM20L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TOMM20L: view

Variants for TOMM20L Gene

Sequence variations from dbSNP and Humsavar for TOMM20L Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000067104 -- 58,402,186(+) ACACT(-/TAAAA)TAATC intron-variant
rs1000199336 -- 58,416,477(+) CAAGA(C/T)ATTCT intron-variant
rs1000200113 -- 58,398,051(+) TAGAG(A/T)ATAAA intron-variant
rs1000242201 -- 58,409,647(+) GATCT(C/T)GGCTC intron-variant
rs1000296070 -- 58,409,959(+) CTCCT(A/G)GGCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TOMM20L Gene

Variant ID Type Subtype PubMed ID
esv2748733 CNV deletion 23290073

Variation tolerance for TOMM20L Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TOMM20L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TOMM20L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOMM20L Gene

Disorders for TOMM20L Gene

Relevant External Links for TOMM20L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TOMM20L

No disorders were found for TOMM20L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TOMM20L Gene

Publications for TOMM20L Gene

  1. Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20. (PMID: 15733919) LikiA8 V.A. … Lithgow T. (J. Mol. Biol. 2005) 2 3 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TOMM20L Gene

Sources for TOMM20L Gene

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