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TOMM20 Gene

protein-coding GIFtS: 65
GCID: GC01M235272

Translocase Of Outer Mitochondrial Membrane 20 Homolog (Yeast)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Translocase Of Outer Mitochondrial Membrane 20 Homolog (Yeast)¹ ²		MOM19²
Translocase Of Outer Mitochondrial Membrane 20 Homolog Type II¹ ²		TOM20²
Mitochondrial 20 KDa Outer Membrane Protein² ³		Mitochondrial Import Receptor Subunit TOM20 Homolog²
Outer Mitochondrial Membrane Receptor Tom20² ³		KIAA0016³
MAS20²

External Ids:	HGNC: 20947¹	Entrez Gene: 9804²	Ensembl: ENSG00000173726⁷	OMIM: 601848⁵	UniProtKB: Q15388³

Export aliases for TOMM20 gene to outside databases

Previous GC identifers: GC00U913004 GC01M232313 GC01M231598 GC01M233339 GC01M205721

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TOMM20 Gene:

TOMM20 (translocase of outer mitochondrial membrane 20 homolog (yeast)) is a protein-coding gene. GO annotations related to this gene include unfolded protein binding and P-P-bond-hydrolysis-driven protein transmembrane transporter activity. An important paralog of this gene is TOMM20L.

UniProtKB/Swiss-Prot: TOM20_HUMAN, Q15388

Function: Central component of the receptor complex responsible for the recognition and translocation of

cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide

receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the

TOM40 translocation pore (By similarity)

Gene Wiki entry for TOMM20 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000001.10 NC_018912.2 NT_167186.2

Regulatory elements:

Regulatory transcription factor binding sites in the TOMM20 gene promoter:
Pax-2 HNF-4alpha2 Pax-2a NF-kappaB YY1 HNF-4alpha1 GATA-1 AREB6 Pax-2b NF-kappaB1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search Chromatin IP Primers for TOMM20

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TOMM20

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42 Ensembl cytogenetic band: 1q42.3 HGNC cytogenetic band: 1q42

TOMM20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOMM20 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M235272: view genomic region (about GC identifiers)

Start:	235,272,651 bp from pter	End:	235,292,256 bp from pter
Size:	19,606 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TOM20_HUMAN, Q15388 (See protein sequence)

Recommended Name: Mitochondrial import receptor subunit TOM20 homolog

Size: 145 amino acids; 16298 Da

Subunit: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which

consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts

with TOM22. Interacts with APEX1

1 PDB 3D structure from and Proteopedia for TOMM20:

4APO (3D)

Secondary accessions: A8K195 Q498B3 Q6IBT4

Explore the universe of human proteins at neXtProt for TOMM20: NX_Q15388

Explore proteomics data for TOMM20 at MOPED

Post-translational modifications:

Ubiquitination² at Lys56

Modification sites at PhosphoSitePlus

See TOMM20 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_055580.1

ENSEMBL proteins:

ENSP00000355566

Reactome Protein details: Q15388

TOMM20 Human Recombinant Protein Products:

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	Novus Biologicals TOMM20 Proteins Novus Biologicals TOMM20 Lysate
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	ProSpec Recombinant Protein for TOMM20
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	antibodies-online proteins for TOMM20 (4 products)
	Search antibodies-online for peptides for TOMM20

TOMM20 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of TOMM20
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	antibodies-online antibodies for TOMM20 (28 products)

TOMM20 Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	Cloud-Clone Corp. ELISAs for TOMM20 Cloud-Clone Corp. CLIAs for TOMM20
	Search eBioscience for ELISAs for TOMM20
	antibodies-online kits for TOMM20 (32 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:

IPR022422 MAS20_rcpt_metazoan

IPR023392 Tom20_dom

IPR002056 MAS20_rcpt-related

Graphical View of Domain Structure for InterPro Entry Q15388

ProtoNet protein and cluster: Q15388

1 Blocks protein domain: IPB002056 MAS20 protein import receptor signature

UniProtKB/Swiss-Prot: TOM20_HUMAN, Q15388

Similarity: Belongs to the Tom20 family

Find genes that share domains with TOMM20 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: TOM20_HUMAN, Q15388

Function: Central component of the receptor complex responsible for the recognition and translocation of

cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide

receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the

TOM40 translocation pore (By similarity)

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	14557246
GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	IDA	14557246
GO:0051082	unfolded protein binding	IDA	14557246

Find genes that share ontologies with TOMM20 About GenesLikeMe

Phenotypes:
1 GenomeRNAi human phenotype for TOMM20:

Synthetic lethal with Ras

1 MGI phenotypic allele

for Tomm20 (no phenotypes)

Find genes that share phenotypes with TOMM20 About GenesLikeMe

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for TOMM20

miRNA Products:		miRTarBase miRNAs that target TOMM20: hsa-let-7d-5p (MIRT032124), hsa-mir-221-3p (MIRT024153), hsa-mir-93-3p (MIRT038775), hsa-mir-155-5p (MIRT020995), hsa-mir-331-3p (MIRT043268), hsa-mir-503-5p (MIRT041097), hsa-mir-20a-5p (MIRT050518)

		Block miRNA regulation of human, mouse, rat TOMM20 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate TOMM20 (see all 52):
		hsa-miR-548j hsa-miR-607 hsa-miR-4328 hsa-miR-15a hsa-miR-938 hsa-miR-424 hsa-miR-9 hsa-miR-155

		SwitchGear 3'UTR luciferase reporter plasmid: TOMM20 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TOMM20
		Predesigned siRNA for gene silencing in human, mouse, rat TOMM20

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TOMM20

Clone Products:		OriGene clones in human, mouse for TOMM20 (see all 6) OriGene ORF clones in mouse, rat for TOMM20 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TOMM20 (NM_014765)
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		Addgene plasmids for TOMM20

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TOMM20
		Browse ESI BIO Cell Lines and PureStem Progenitors for TOMM20

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM20

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

TOM20_HUMAN, Q15388: Mitochondrion outer membrane; Single-pass membrane protein (Potential)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
mitochondrion	5
cytosol	2
extracellular	2
endoplasmic reticulum	1
nucleus	1
peroxisome	1
plasma membrane	1

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Gene Ontology (GO): 5 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IDA	--
GO:0005740	mitochondrial envelope	--	--
GO:0005741	mitochondrial outer membrane	--	--
GO:0005742	mitochondrial outer membrane translocase complex	TAS	14557246
GO:0016021	integral component of membrane	IEA	--

Find genes that share ontologies with TOMM20 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for TOMM20 About

See pathways by source

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by

SuperPath

Contained pathways About

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

Metabolism of proteins

0.30

Mitochondrial Protein Import

Mitochondrial Protein Import

Find genes that share SuperPaths with TOMM20 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

1 Reactome Pathway for TOMM20

Mitochondrial protein import

Pathway & Disease-focused RT² Profiler PCR Array including TOMM20:

Mitochondria in human mouse rat

Interactions:

GeneGlobe Interaction Network for TOMM20

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for TOMM20 (Q15388^{2, 3} ENSP00000355566⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 75)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BAG6	P46379²^,³	MINT-64241 I2D: score=5
ENSG00000096155	P46379²^,³	MINT-64241 I2D: score=5
ENSG00000227761	P46379²^,³	MINT-64241 I2D: score=5
ENSG00000228760	P46379²^,³	MINT-64241 I2D: score=5
ENSG00000229524	P46379²^,³	MINT-64241 I2D: score=5

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Gene Ontology (GO): 5 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006605	protein targeting	--	--
GO:0006626	protein targeting to mitochondrion	TAS	--
GO:0006886	intracellular protein transport	--	--
GO:0044267	cellular protein metabolic process	TAS	--
GO:0071806	protein transmembrane transport	IDA	14557246

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for TOMM20 (TOM20)

2 Novoseek inferred chemical compound relationships for TOMM20 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
malate	35.3	1	11029287 (1)
atp	0	1	9211931 (1)

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TOMM20 gene:

NM_014765.2

Unigene Cluster for TOMM20:

Translocase of outer mitochondrial membrane 20 homolog (yeast)

Hs.533192 [show with all ESTs]

Unigene Representative Sequence: NM_014765

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000366607(uc001hwl.3) ENST00000467767 ENST00000473132

miRNA Products:		Block miRNA regulation of human, mouse, rat TOMM20 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate TOMM20 (see all 52):
		hsa-miR-548j hsa-miR-607 hsa-miR-4328 hsa-miR-15a hsa-miR-938 hsa-miR-424 hsa-miR-9 hsa-miR-155

		SwitchGear 3'UTR luciferase reporter plasmid: TOMM20 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TOMM20
		Predesigned siRNA for gene silencing in human, mouse, rat TOMM20

Clone Products:		OriGene clones in human, mouse for TOMM20 (see all 6) OriGene ORF clones in mouse, rat for TOMM20 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TOMM20 (NM_014765)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOMM20
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Primer Products:		OriGene qPCR primer pairs and template standards for TOMM20 OriGene qSTAR qPCR primer pairs in human, mouse for TOMM20
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat TOMM20
		QuantiTect SYBR Green Assays in human, mouse, rat TOMM20
		QuantiFast Probe-based Assays in human, mouse, rat TOMM20

Additional mRNA sequence:

AK289810.1 BC000882.1 BC009886.2 BC066335.1 BC071994.1 BC100286.1 BC107851.1 CR456718.1

D13641.1

Selected DOTS entries (see all 33):

DT.95163931 DT.95163927 DT.100684522 DT.121335406 DT.85105182 DT.101983019 DT.100848050 DT.100684523

DT.95163913 DT.100658026 DT.121335384 DT.91794195 DT.101975247 DT.121335441 DT.100664733 DT.100865287

DT.95163929 DT.100705173 DT.100732175 DT.100854094 DT.102835480 DT.121335442 DT.121335446 DT.207468

Selected AceView cDNA sequences (see all 899):

AA724567 H99657 CB177879 AU128188 CD677576 AI203601 BU624747 NM_014765

AU120547 AA644550 AI284088 BM555447 AA634684 BU838445 BQ649285 BE350613

AI050868 BQ417009 AW002024 BF346299 BQ717850 BU181897 BQ416810 BP430526

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for TOMM20 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b
SP1:							-								-		-										-
SP2:							-
SP3:							-								-
SP4:							-						-		-		-		-		-						-
SP5:							-								-		-

ECgene alternative splicing isoforms for TOMM20

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TOMM20 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CAGATAACAT

About this image

TOMM20 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 17) fully expand


Brain (Nervous System) fully expand to see all 4 entries
Cerebral Cortex

Ovary (Reproductive System) fully expand to see all 2 entries
Ovarian Mesenchymal Stroma Cells Ovary Interstitium
Oviduct

Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast

Testis (Reproductive System)
Leydig Cells Testis Interstitium

Bone (Muscoskeletal System)
Bone Marrow

TOMM20 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

TOMM20 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.533192

Pathway & Disease-focused RT² Profiler PCR Array including TOMM20:

Mitochondria in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for TOMM20 OriGene qSTAR qPCR primer pairs in human, mouse for TOMM20
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat TOMM20
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		QuantiFast Probe-based Assays in human, mouse, rat TOMM20

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM20

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for TOMM20 gene from Selected species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tomm20^{1 , 5}	translocase of outer mitochondrial membrane 20 homolog (yeast) less^{1, 5}	92.18(n)¹ 99.31(a)¹		8 (74.64 cM)⁵ 67952¹ NM_024214.2¹ NP_077176.1¹ 126930664⁵
chicken (Gallus gallus)	Aves	TOMM20¹	translocase of outer mitochondrial membrane 20 homolog (yeast) less	85.98(n) 97.24(a)		426309 XM_423972.4 XP_423972.3
lizard (Anolis carolinensis)	Reptilia	TOMM20⁶	translocase of outer mitochondrial membrane 20 hom...	92(a)	1 ↔ 1	1(219649795-219660250)
African clawed frog (Xenopus laevis)	Amphibia	tomm20-pending-prov²	translocase of outer mitochondrial membrane 20 homolog (yeast) less	79.36(n)		BC041212.1
zebrafish (Danio rerio)	Actinopterygii	Dr.15589²	Transcribed sequence with moderate similarity to protein pirS66619 (H.sapiens) S66619 Mas 20 protein - human less	75.88(n)		CF595012.1
fruit fly (Drosophila melanogaster)	Insecta	Tom20¹	Translocase of outer membrane 20	58.6(n) 58.87(a)		40189 NM_001275156.1 NP_001262085.1
worm (Caenorhabditis elegans)	Secernentea	tomm-20¹	tomm-20	49.17(n) 43.26(a)		179691 NM_073691.5 NP_506092.1
wheat (Triticum aestivum)	Liliopsida	Ta.26866²	Triticum aestivum transcribed sequence with weak similarity to protein pirS66619 (H.sapiens) S66619 Mas 20 protein - human less	70.16(n)		CD491502.1

ENSEMBL Gene Tree for TOMM20 (if available)
TreeFam Gene Tree for TOMM20 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for TOMM20 gene

TOMM20L²

1 SIMAP similar gene for TOMM20 using alignment to 1 protein entry: TOM20_HUMAN:

TOMM20L

Find genes that share paralogs with TOMM20 About GenesLikeMe

5 Pseudogenes.org Pseudogenes for TOMM20
PGOHUM00000242811 PGOHUM00000237036 PGOHUM00000234849 PGOHUM00000232849 PGOHUM00000241843

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1134889^1,2	C,F,H	--	235272186(-)	`TTGTAG/ATTTTG`	1	--	int¹		10		MN NS EA NA WA	936
rs75000312^1,2	C	--	235272200(+)	`CTCTC-/AT/TA AGATC`	1	--	int¹		0	--	--	--	--
rs7411516^1,2	C,F,H	--	235272357(+)	`ACAAGC/TCTTCA`	1	--	int¹		16		NS EA NA	1614
rs143454227^1,2	C	--	235272373(+)	`CGCACA/GTCAGC`	1	--	int¹		0	--	--	--	--
rs75027125^1,2	C,F	--	235272407(+)	`ACGAAC/TCTGTT`	1	--	int¹		1		WA	118
rs115669824^1,2	C,F	--	235272428(+)	`TCCCAG/AGTGAC`	1	--	int¹		1		WA	118
rs74490586^1,2	C,F	--	235272545(+)	`GGCAGG/AGAAGC`	1	--	int¹		1		WA	118
rs186098881^1,2		--	235272578(+)	`AGACGG/TTAACA`	1	--	int¹		0	--	--	--	--
rs190625529^1,2		--	235272725(+)	`TTTTAC/TGTTAC`	1	--	ut3¹		0	--	--	--	--
rs183335513^1,2		--	235272892(+)	`CAAACA/GTTTAC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TOMM20 (235272651 - 235292256 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for TOMM20: About this table

Variant ID	Type	Subtype	PubMed ID
esv275126	CNV	Loss	21479260
nsv508699	CNV	Loss	20534489

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 601848 OMIM disorders: --

Find genes that share disorders with TOMM20 About GenesLikeMe

Genetic Association Database (GAD): TOMM20
Human Genome Epidemiology (HuGE) Navigator: TOMM20 (1 document)

Export disorders for TOMM20 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TOMM20 gene, integrated from 10 sources (see all 77):
(articles sorted by number of sources associating them with TOMM20)

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A human homolog of the mitochondrial protein import receptor Mom19 can assemble with the yeast mitochondrial receptor complex. (PubMed id 7498524)^{1, 2, 3} Seki N.... Pfanner N. (FEBS Lett. 1995)
Identification of the human mitochondrial protein import receptor, huMas20p. Complementation of delta mas20 in yeast. (PubMed id 7589431)^{1, 2, 3} Goping I.S.... Shore G.C. (FEBS Lett. 1995)
Gene structure of the human mitochondrial outer membrane receptor tom20 and evolutionary study of its family of processed pseudogenes. (PubMed id 10548729)^{1, 2, 9} Hernandez J.M.... Hernandez-Yago J. (Gene 1999)
Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)^{1, 4} Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (Nature 2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (Cell 2006)
Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20. (PubMed id 15733919)^{1, 3} LikiA8 V.A....Lithgow T. (J. Mol. Biol. 2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)^{1, 2} Nomura N.... Tabata S. (DNA Res. 1994)
Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity. (PubMed id 14699115)^{1, 9} Yano M....Mori M. (J. Biol. Chem. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9804	HGNC: 20947	AceView: TOMM20	Ensembl:ENSG00000173726	euGenes: HUgn9804
ECgene: TOMM20	H-InvDB: TOMM20

(According to HUGE)
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HUGE: KIAA0016

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TOMM20	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TOMM20	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TOMM20 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TOMM20 gene:
Search GeneIP for patents involving TOMM20

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TOMM20 Gene

Translocase Of Outer Mitochondrial Membrane 20 Homolog (Yeast)

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TOMM20 Gene

Translocase Of Outer Mitochondrial Membrane 20 Homolog (Yeast)

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