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Aliases for TOMM20 Gene

Aliases for TOMM20 Gene

  • Translocase Of Outer Mitochondrial Membrane 20 2 3
  • Translocase Of Outer Mitochondrial Membrane 20 Homolog Type II 2 3
  • Translocase Of Outer Mitochondrial Membrane 20 Homolog (Yeast) 2 5
  • Mitochondrial 20 KDa Outer Membrane Protein 3 4
  • Outer Mitochondrial Membrane Receptor Tom20 3 4
  • KIAA0016 4
  • MAS20 3
  • MOM19 3
  • TOM20 3

External Ids for TOMM20 Gene

Previous GeneCards Identifiers for TOMM20 Gene

  • GC00U913004
  • GC01M232313
  • GC01M231598
  • GC01M233339
  • GC01M235272
  • GC01M205721

Summaries for TOMM20 Gene

GeneCards Summary for TOMM20 Gene

TOMM20 (Translocase Of Outer Mitochondrial Membrane 20) is a Protein Coding gene. Diseases associated with TOMM20 include perry syndrome. Among its related pathways are Transport to the Golgi and subsequent modification and Mitochondrial protein import. GO annotations related to this gene include unfolded protein binding and P-P-bond-hydrolysis-driven protein transmembrane transporter activity. An important paralog of this gene is TOMM20L.

UniProtKB/Swiss-Prot for TOMM20 Gene

  • Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).

Gene Wiki entry for TOMM20 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOMM20 Gene

Genomics for TOMM20 Gene

Regulatory Elements for TOMM20 Gene

Promoters for TOMM20 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TOMM20 on UCSC Golden Path with GeneCards custom track

Genomic Location for TOMM20 Gene

Chromosome:
1
Start:
235,109,336 bp from pter
End:
235,128,941 bp from pter
Size:
19,606 bases
Orientation:
Minus strand

Genomic View for TOMM20 Gene

Genes around TOMM20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOMM20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOMM20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOMM20 Gene

Proteins for TOMM20 Gene

  • Protein details for TOMM20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15388-TOM20_HUMAN
    Recommended name:
    Mitochondrial import receptor subunit TOM20 homolog
    Protein Accession:
    Q15388
    Secondary Accessions:
    • A8K195
    • Q498B3
    • Q6IBT4

    Protein attributes for TOMM20 Gene

    Size:
    145 amino acids
    Molecular mass:
    16298 Da
    Quaternary structure:
    • Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with TOM22. Interacts with APEX1.

    Three dimensional structures from OCA and Proteopedia for TOMM20 Gene

neXtProt entry for TOMM20 Gene

Proteomics data for TOMM20 Gene at MOPED

Post-translational modifications for TOMM20 Gene

  • Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
  • Ubiquitination at Lys 35, Lys 56, Lys 61, and Lys 68
  • Modification sites at PhosphoSitePlus

Other Protein References for TOMM20 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TOMM20 (TOM20)

No data available for DME Specific Peptides for TOMM20 Gene

Domains & Families for TOMM20 Gene

Protein Domains for TOMM20 Gene

Suggested Antigen Peptide Sequences for TOMM20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15388

UniProtKB/Swiss-Prot:

TOM20_HUMAN :
  • Belongs to the Tom20 family.
Family:
  • Belongs to the Tom20 family.
genes like me logo Genes that share domains with TOMM20: view

Function for TOMM20 Gene

Molecular function for TOMM20 Gene

UniProtKB/Swiss-Prot Function:
Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).

Gene Ontology (GO) - Molecular Function for TOMM20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051082 unfolded protein binding IEA,IDA 14557246
genes like me logo Genes that share ontologies with TOMM20: view
genes like me logo Genes that share phenotypes with TOMM20: view

Animal Model Products

CRISPR Products

miRNA for TOMM20 Gene

miRTarBase miRNAs that target TOMM20

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TOMM20 Gene

Localization for TOMM20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOMM20 Gene

Mitochondrion outer membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TOMM20 Gene COMPARTMENTS Subcellular localization image for TOMM20 gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 2
chloroplast 1
endoplasmic reticulum 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TOMM20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005742 mitochondrial outer membrane translocase complex IEA,TAS 14557246
genes like me logo Genes that share ontologies with TOMM20: view

Pathways & Interactions for TOMM20 Gene

genes like me logo Genes that share pathways with TOMM20: view

Pathways by source for TOMM20 Gene

Gene Ontology (GO) - Biological Process for TOMM20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016031 tRNA import into mitochondrion IBA --
genes like me logo Genes that share ontologies with TOMM20: view

No data available for SIGNOR curated interactions for TOMM20 Gene

Drugs & Compounds for TOMM20 Gene

(1) Drugs for TOMM20 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for TOMM20 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TOMM20: view

Transcripts for TOMM20 Gene

mRNA/cDNA for TOMM20 Gene

Unigene Clusters for TOMM20 Gene

Translocase of outer mitochondrial membrane 20 homolog (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOMM20 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b
SP1: - - - -
SP2: -
SP3: - -
SP4: - - - - - - -
SP5: - - -
SP6: - - -
SP7: - -

Relevant External Links for TOMM20 Gene

GeneLoc Exon Structure for
TOMM20
ECgene alternative splicing isoforms for
TOMM20

Expression for TOMM20 Gene

mRNA expression in normal human tissues for TOMM20 Gene

Protein differential expression in normal tissues from HIPED for TOMM20 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.1), Bone (8.1), and Brain (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TOMM20 Gene



SOURCE GeneReport for Unigene cluster for TOMM20 Gene Hs.533192

genes like me logo Genes that share expression patterns with TOMM20: view

Protein tissue co-expression partners for TOMM20 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TOMM20 Gene

Orthologs for TOMM20 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TOMM20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOMM20 36
  • 100 (a)
OneToOne
TOMM20 35
  • 99.54 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia TOMM20 35
  • 94.94 (n)
  • 100 (a)
TOMM20 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TOMM20 36
  • 99 (a)
OneToOne
TOMM20 35
  • 94.25 (n)
  • 99.31 (a)
mouse
(Mus musculus)
Mammalia Tomm20 16
Tomm20 36
  • 99 (a)
OneToOne
Tomm20 35
  • 92.18 (n)
  • 99.31 (a)
oppossum
(Monodelphis domestica)
Mammalia TOMM20 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TOMM20 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tomm20 35
  • 91.95 (n)
  • 97.93 (a)
chicken
(Gallus gallus)
Aves TOMM20 35
  • 85.98 (n)
  • 97.24 (a)
TOMM20 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TOMM20 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia tomm20-pending-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11143 35
tomm20 35
  • 79.54 (n)
  • 88.97 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6481 35
zebrafish
(Danio rerio)
Actinopterygii tomm20b 36
  • 50 (a)
OneToOne
Dr.15589 35
tomm20b 35
  • 74.94 (n)
  • 86.9 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012339 35
  • 61.07 (n)
  • 59.2 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tom20 36
  • 45 (a)
ManyToMany
tomboy20 36
  • 39 (a)
ManyToMany
Tom20 35
  • 58.6 (n)
  • 58.87 (a)
worm
(Caenorhabditis elegans)
Secernentea tomm-20 35
  • 49.17 (n)
  • 43.26 (a)
tomm-20 36
  • 33 (a)
OneToMany
wheat
(Triticum aestivum)
Liliopsida Ta.26866 35
Species with no ortholog for TOMM20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for TOMM20 Gene

ENSEMBL:
Gene Tree for TOMM20 (if available)
TreeFam:
Gene Tree for TOMM20 (if available)

Paralogs for TOMM20 Gene

Paralogs for TOMM20 Gene

(1) SIMAP similar genes for TOMM20 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TOMM20: view

Variants for TOMM20 Gene

Sequence variations from dbSNP and Humsavar for TOMM20 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_052366 -
VAR_052367 -
rs7930 -- 235,109,879(-) AGAAC(A/G)AAAAA utr-variant-3-prime
rs4075195 -- 235,125,097(+) TACAC(C/T)TCAAG intron-variant
rs4076568 -- 235,125,254(+) ttgtc(A/G)cccag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TOMM20 Gene

Variant ID Type Subtype PubMed ID
nsv508699 CNV Loss 20534489
esv275126 CNV Loss 21479260

Variation tolerance for TOMM20 Gene

Residual Variation Intolerance Score: 42.4% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TOMM20 Gene

HapMap Linkage Disequilibrium report
TOMM20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOMM20 Gene

Disorders for TOMM20 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TOMM20 Gene - From: DISEASES

Disorder Aliases PubMed IDs
perry syndrome
  • parkinsonism with alveolar hypoventilation and mental depression
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TOMM20

Genetic Association Database (GAD)
TOMM20
Human Genome Epidemiology (HuGE) Navigator
TOMM20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TOMM20
genes like me logo Genes that share disorders with TOMM20: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TOMM20 Gene

Publications for TOMM20 Gene

  1. A human homolog of the mitochondrial protein import receptor Mom19 can assemble with the yeast mitochondrial receptor complex. (PMID: 7498524) Seki N. … Pfanner N. (FEBS Lett. 1995) 2 3 4 67
  2. Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20. (PMID: 15733919) LikiA8 V.A. … Lithgow T. (J. Mol. Biol. 2005) 2 3
  3. Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity. (PMID: 14699115) Yano M. … Mori M. (J. Biol. Chem. 2004) 3 23
  4. AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and preproteins. (PMID: 14557246) Yano M. … Mori M. (J. Cell Biol. 2003) 3 23
  5. Identification and functional analysis of human Tom22 for protein import into mitochondria. (PMID: 10982837) Yano M. … Mori M. (Mol. Cell. Biol. 2000) 3 23

Products for TOMM20 Gene

Sources for TOMM20 Gene

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