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Aliases for TOMM20 Gene

Aliases for TOMM20 Gene

  • Translocase Of Outer Mitochondrial Membrane 20 Homolog (Yeast) 2 3
  • Translocase Of Outer Mitochondrial Membrane 20 Homolog Type II 2 3
  • Mitochondrial 20 KDa Outer Membrane Protein 3 4
  • Outer Mitochondrial Membrane Receptor Tom20 3 4
  • KIAA0016 4
  • MAS20 3
  • MOM19 3
  • TOM20 3

External Ids for TOMM20 Gene

Previous GeneCards Identifiers for TOMM20 Gene

  • GC00U913004
  • GC01M232313
  • GC01M231598
  • GC01M233339
  • GC01M235272
  • GC01M205721

Summaries for TOMM20 Gene

GeneCards Summary for TOMM20 Gene

TOMM20 (Translocase Of Outer Mitochondrial Membrane 20 Homolog (Yeast)) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Glucose / Energy Metabolism. GO annotations related to this gene include unfolded protein binding and P-P-bond-hydrolysis-driven protein transmembrane transporter activity. An important paralog of this gene is TOMM20L.

UniProtKB/Swiss-Prot for TOMM20 Gene

  • Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).

Gene Wiki entry for TOMM20 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOMM20 Gene

Genomics for TOMM20 Gene

Regulatory Elements for TOMM20 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TOMM20 Gene

Chromosome:
1
Start:
235,109,336 bp from pter
End:
235,128,941 bp from pter
Size:
19,606 bases
Orientation:
Minus strand

Genomic View for TOMM20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TOMM20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOMM20 Gene

Proteins for TOMM20 Gene

  • Protein details for TOMM20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15388-TOM20_HUMAN
    Recommended name:
    Mitochondrial import receptor subunit TOM20 homolog
    Protein Accession:
    Q15388
    Secondary Accessions:
    • A8K195
    • Q498B3
    • Q6IBT4

    Protein attributes for TOMM20 Gene

    Size:
    145 amino acids
    Molecular mass:
    16298 Da
    Quaternary structure:
    • Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with TOM22. Interacts with APEX1.

    Three dimensional structures from OCA and Proteopedia for TOMM20 Gene

neXtProt entry for TOMM20 Gene

Proteomics data for TOMM20 Gene at MOPED

Post-translational modifications for TOMM20 Gene

  • Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
  • Ubiquitination at Lys 35, Lys 56, Lys 61, and Lys 68
  • Modification sites at PhosphoSitePlus

Other Protein References for TOMM20 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TOMM20 (TOM20)

No data available for DME Specific Peptides for TOMM20 Gene

Domains & Families for TOMM20 Gene

Protein Domains for TOMM20 Gene

Suggested Antigen Peptide Sequences for TOMM20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15388

UniProtKB/Swiss-Prot:

TOM20_HUMAN :
  • Belongs to the Tom20 family.
Family:
  • Belongs to the Tom20 family.
genes like me logo Genes that share domains with TOMM20: view

No data available for Gene Families for TOMM20 Gene

Function for TOMM20 Gene

Molecular function for TOMM20 Gene

UniProtKB/Swiss-Prot Function:
Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).

Gene Ontology (GO) - Molecular Function for TOMM20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14557246
GO:0015266 contributes_to protein channel activity IBA --
GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity IDA 14557246
GO:0030943 mitochondrion targeting sequence binding IBA --
GO:0051082 unfolded protein binding IDA 14557246
genes like me logo Genes that share ontologies with TOMM20: view

Phenotypes for TOMM20 Gene

genes like me logo Genes that share phenotypes with TOMM20: view

Animal Model Products

CRISPR Products

miRNA for TOMM20 Gene

miRTarBase miRNAs that target TOMM20

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TOMM20

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TOMM20 Gene

Localization for TOMM20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOMM20 Gene

Mitochondrion outer membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TOMM20 Gene COMPARTMENTS Subcellular localization image for TOMM20 gene
Compartment Confidence
mitochondrion 5
cytosol 2
chloroplast 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TOMM20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005740 mitochondrial envelope --
GO:0005741 mitochondrial outer membrane TAS --
GO:0005742 mitochondrial outer membrane translocase complex TAS 14557246
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with TOMM20: view

Pathways & Interactions for TOMM20 Gene

genes like me logo Genes that share pathways with TOMM20: view

Pathways by source for TOMM20 Gene

2 Cell Signaling Technology pathways for TOMM20 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TOMM20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000423 macromitophagy TAS --
GO:0006605 protein targeting --
GO:0006626 protein targeting to mitochondrion TAS --
GO:0006886 intracellular protein transport --
GO:0016031 tRNA import into mitochondrion IBA --
genes like me logo Genes that share ontologies with TOMM20: view

No data available for SIGNOR curated interactions for TOMM20 Gene

Drugs & Compounds for TOMM20 Gene

(1) Drugs for TOMM20 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Pharma Activator 0

(1) Additional Compounds for TOMM20 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
malate
genes like me logo Genes that share compounds with TOMM20: view

Transcripts for TOMM20 Gene

mRNA/cDNA for TOMM20 Gene

Unigene Clusters for TOMM20 Gene

Translocase of outer mitochondrial membrane 20 homolog (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TOMM20

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOMM20 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b
SP1: - - - -
SP2: -
SP3: - -
SP4: - - - - - - -
SP5: - - -
SP6: - - -
SP7: - -

Relevant External Links for TOMM20 Gene

GeneLoc Exon Structure for
TOMM20
ECgene alternative splicing isoforms for
TOMM20

Expression for TOMM20 Gene

mRNA expression in normal human tissues for TOMM20 Gene

Protein differential expression in normal tissues from HIPED for TOMM20 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.1), Bone (8.1), and Brain (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TOMM20 Gene



SOURCE GeneReport for Unigene cluster for TOMM20 Gene Hs.533192

genes like me logo Genes that share expression patterns with TOMM20: view

Protein tissue co-expression partners for TOMM20 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TOMM20 Gene

Orthologs for TOMM20 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TOMM20 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TOMM20 35
  • 94.94 (n)
  • 100 (a)
TOMM20 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TOMM20 35
  • 94.25 (n)
  • 99.31 (a)
TOMM20 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tomm20 35
  • 92.18 (n)
  • 99.31 (a)
Tomm20 16
Tomm20 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TOMM20 35
  • 99.54 (n)
  • 100 (a)
TOMM20 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tomm20 35
  • 91.95 (n)
  • 97.93 (a)
oppossum
(Monodelphis domestica)
Mammalia TOMM20 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TOMM20 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves TOMM20 35
  • 85.98 (n)
  • 97.24 (a)
TOMM20 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TOMM20 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11143 35
tomm20 35
  • 79.54 (n)
  • 88.97 (a)
African clawed frog
(Xenopus laevis)
Amphibia tomm20-pending-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.15589 35
tomm20b 35
  • 74.94 (n)
  • 86.9 (a)
tomm20b 36
  • 50 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6481 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012339 35
  • 61.07 (n)
  • 59.2 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tom20 35
  • 58.6 (n)
  • 58.87 (a)
Tom20 36
  • 45 (a)
ManyToMany
tomboy20 36
  • 39 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea tomm-20 35
  • 49.17 (n)
  • 43.26 (a)
tomm-20 36
  • 33 (a)
OneToMany
wheat
(Triticum aestivum)
Liliopsida Ta.26866 35
Species with no ortholog for TOMM20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for TOMM20 Gene

ENSEMBL:
Gene Tree for TOMM20 (if available)
TreeFam:
Gene Tree for TOMM20 (if available)

Paralogs for TOMM20 Gene

Paralogs for TOMM20 Gene

(1) SIMAP similar genes for TOMM20 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TOMM20: view

Variants for TOMM20 Gene

Sequence variations from dbSNP and Humsavar for TOMM20 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs6913 -- 235,112,052(-) AATGT(C/T)AACAT utr-variant-3-prime
rs7930 -- 235,109,879(-) AGAAC(A/G)AAAAA utr-variant-3-prime
rs11301 -- 235,109,864(-) CAGAT(C/T)TCAGT utr-variant-3-prime
rs1130651 -- 235,111,855(-) TCATT(C/T)TATAA utr-variant-3-prime
rs1130654 -- 235,111,816(-) GATTT(C/T)GTTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TOMM20 Gene

Variant ID Type Subtype PubMed ID
nsv508699 CNV Loss 20534489
esv275126 CNV Loss 21479260

Variation tolerance for TOMM20 Gene

Residual Variation Intolerance Score: 42.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TOMM20 Gene

HapMap Linkage Disequilibrium report
TOMM20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOMM20 Gene

Disorders for TOMM20 Gene

Relevant External Links for TOMM20

Genetic Association Database (GAD)
TOMM20
Human Genome Epidemiology (HuGE) Navigator
TOMM20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TOMM20
genes like me logo Genes that share disorders with TOMM20: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TOMM20 Gene

Publications for TOMM20 Gene

  1. Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. (PMID: 18331822) Kato H. … Mihara K. (Biochem. Biophys. Res. Commun. 2008) 23 67
  2. Biogenesis of the mitochondrial TOM complex: Mim1 promotes insertion and assembly of signal-anchored receptors. (PMID: 17974559) Becker T. … Wiedemann N. (J. Biol. Chem. 2008) 23 67
  3. Two-color far-field fluorescence nanoscopy. (PMID: 17307826) Donnert G. … Hell S.W. (Biophys. J. 2007) 23 67
  4. Chronic exposure to sub-lethal beta-amyloid (Abeta) inhibits the import of nuclear-encoded proteins to mitochondria in differentiated PC12 cells. (PMID: 17868329) Sirk D. … Mills L.R. (J. Neurochem. 2007) 23 67
  5. Tom20 recognizes mitochondrial presequences through dynamic equilibrium among multiple bound states. (PMID: 17948058) Saitoh T. … Kohda D. (EMBO J. 2007) 23 67

Products for TOMM20 Gene

Sources for TOMM20 Gene

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