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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TOMM20 Gene

protein-coding GIFtS: 63
GCID: GC01M235272

Translocase Of Outer Mitochondrial Membrane 20 Homolog (Yeast)

See related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Translocase Of Outer Mitochondrial Membrane 20 Homolog (Yeast)¹ ²		MOM19²
Translocase Of Outer Mitochondrial Membrane 20 Homolog Type II¹ ²		TOM20²
Mitochondrial 20 KDa Outer Membrane Protein² ³		Mitochondrial Import Receptor Subunit TOM20 Homolog²
Outer Mitochondrial Membrane Receptor Tom20² ³		KIAA0016³
MAS20²

External Ids:	HGNC: 20947¹	Entrez Gene: 9804²	Ensembl: ENSG00000173726⁷	OMIM: 601848⁵	UniProtKB: Q15388³

Export aliases for TOMM20 gene to outside databases

Previous GC identifers: GC00U913004 GC01M232313 GC01M231598 GC01M233339 GC01M205721

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TOMM20 Gene:

TOMM20 (translocase of outer mitochondrial membrane 20 homolog (yeast)) is a protein-coding gene. Diseases associated with TOMM20 include smallpox, and among its related super-pathways are Post-translational protein modification. GO annotations related to this gene include unfolded protein binding and P-P-bond-hydrolysis-driven protein transmembrane transporter activity. An important paralog of this gene is TOMM20L.

UniProtKB/Swiss-Prot: TOM20_HUMAN, Q15388

Function: Central component of the receptor complex responsible for the recognition and translocation of

cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide

receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the

TOM40 translocation pore (By similarity)

Gene Wiki entry for TOMM20 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.2 NT_167186.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TOMM20 gene promoter:
Pax-2 HNF-4alpha2 Pax-2a NF-kappaB YY1 HNF-4alpha1 GATA-1 AREB6 Pax-2b NF-kappaB1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for TOMM20

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOMM20

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42 Ensembl cytogenetic band: 1q42.3 HGNC cytogenetic band: 1q42

TOMM20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOMM20 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M235272: view genomic region (about GC identifiers)

Start:	235,272,651 bp from pter	End:	235,292,256 bp from pter
Size:	19,606 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TOM20_HUMAN, Q15388 (See protein sequence)

Recommended Name: Mitochondrial import receptor subunit TOM20 homolog

Size: 145 amino acids; 16298 Da

Subunit: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which

consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts

with TOM22. Interacts with APEX1

Subcellular location: Mitochondrion outer membrane; Single-pass membrane protein (Potential)

1 PDB 3D structure from and Proteopedia for TOMM20:

4APO (3D)

Secondary accessions: A8K195 Q498B3 Q6IBT4

Explore the universe of human proteins at neXtProt for TOMM20: NX_Q15388

Explore proteomics data for TOMM20 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q15388

TOMM20 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_055580.1

ENSEMBL proteins:

ENSP00000355566

Reactome Protein details: Q15388
Human Recombinant Protein Products for TOMM20:

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	Novus Biologicals TOMM20 Proteins Novus Biologicals TOMM20 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for TOMM20

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IDA	--
GO:0005740	mitochondrial envelope	--	--
GO:0005741	mitochondrial outer membrane	--	--
GO:0005742	mitochondrial outer membrane translocase complex	TAS	14557246
GO:0016021	integral to membrane	IEA	--

TOMM20 for ontologies About GeneDecksing

TOMM20 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of TOMM20
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	Novus Biologicals TOMM20 Antibodies
	Abcam antibodies for TOMM20
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	LSBio Antibodies in human, mouse, rat for TOMM20

Assay Products for TOMM20:

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	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for TOMM20 Cloud-Clone Corp. CLIAs for TOMM20

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

3 InterPro protein domains:

IPR022422 MAS20_rcpt_metazoan

IPR023392 Tom20_dom

IPR002056 MAS20_rcpt-related

Graphical View of Domain Structure for InterPro Entry Q15388

ProtoNet protein and cluster: Q15388

1 Blocks protein domain: IPB002056 MAS20 protein import receptor signature

UniProtKB/Swiss-Prot: TOM20_HUMAN, Q15388

Similarity: Belongs to the Tom20 family

TOMM20 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TOM20_HUMAN, Q15388

Function: Central component of the receptor complex responsible for the recognition and translocation of

cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide

receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the

TOM40 translocation pore (By similarity)

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	14557246
GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	IDA	14557246
GO:0051082	unfolded protein binding	IDA	14557246

TOMM20 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for TOMM20:

Synthetic lethal with Ras

1 MGI phenotypic allele

for Tomm20 (no phenotypes)

TOMM20 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for TOMM20

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TOMM20

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TOMM20

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TOMM20

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TOMM20
		8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate TOMM20 (see all 52):
		hsa-miR-548j hsa-miR-607 hsa-miR-4328 hsa-miR-15a hsa-miR-938 hsa-miR-424 hsa-miR-9 hsa-miR-155

		SwitchGear 3'UTR luciferase reporter plasmid: TOMM20 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for TOMM20
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOMM20

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TOMM20
			Sirion Biotech Customized adenovirus for overexpression of TOMM20

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for TOMM20 (see all 6) OriGene ORF clones in mouse, rat for TOMM20 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TOMM20 (NM_014765)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TOMM20
		Search LifeMap BioReagents cell lines for TOMM20

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM20

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for TOMM20 About

See pathways by source

SuperPath

Contained pathways About

Asparagine N-linked glycosylation

Metabolism of proteins

0.35

Mitochondrial Protein Import

Mitochondrial Protein Import

Pathways by source See SuperPaths
Show all pathways

2 Reactome Pathways for TOMM20

	Mitochondrial Protein Import
	Metabolism of proteins

TOMM20 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TOMM20

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/64 Interacting proteins for TOMM20 (Q15388^{2, 3} ENSP00000355566⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 64)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BAG6	P46379²^,³	MINT-64241 I2D: score=5
ENSG00000096155	P46379²^,³	MINT-64241 I2D: score=5
ENSG00000227761	P46379²^,³	MINT-64241 I2D: score=5
ENSG00000228760	P46379²^,³	MINT-64241 I2D: score=5
ENSG00000229524	P46379²^,³	MINT-64241 I2D: score=5

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006605	protein targeting	--	--
GO:0006626	protein targeting to mitochondrion	TAS	--
GO:0006886	intracellular protein transport	--	--
GO:0044267	cellular protein metabolic process	TAS	--

TOMM20 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TOMM20 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TOMM20 (TOM20)

2 Novoseek inferred chemical compound relationships for TOMM20 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
malate	35.3	1	11029287 (1)
atp	0	1	9211931 (1)

Search CenterWatch for drugs/clinical trials and news about TOMM20 / TOM20

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TOMM20 gene:

NM_014765.2

Unigene Cluster for TOMM20:

Translocase of outer mitochondrial membrane 20 homolog (yeast)

Hs.533192 [show with all ESTs]

Unigene Representative Sequence: NM_014765

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000366607(uc001hwl.3) ENST00000467767 ENST00000473132

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TOMM20
		8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate TOMM20 (see all 52):
		hsa-miR-548j hsa-miR-607 hsa-miR-4328 hsa-miR-15a hsa-miR-938 hsa-miR-424 hsa-miR-9 hsa-miR-155

		SwitchGear 3'UTR luciferase reporter plasmid: TOMM20 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for TOMM20
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Clone Products:		OriGene clones in human, mouse for TOMM20 (see all 6) OriGene ORF clones in mouse, rat for TOMM20 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TOMM20 (NM_014765)
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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TOMM20
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOMM20
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOMM20

Additional mRNA sequence:

AK289810.1 BC000882.1 BC009886.2 BC066335.1 BC071994.1 BC100286.1 BC107851.1 CR456718.1

D13641.1

24/33 DOTS entries (see all 33):

DT.95163931 DT.95163927 DT.100684522 DT.121335406 DT.85105182 DT.101983019 DT.100848050 DT.100684523

DT.95163913 DT.100658026 DT.121335384 DT.91794195 DT.101975247 DT.121335441 DT.100664733 DT.100865287

DT.95163929 DT.100705173 DT.100732175 DT.100854094 DT.102835480 DT.121335442 DT.121335446 DT.207468

24/899 AceView cDNA sequences (see all 899):

AA296605 BP383385 AW516234 AA702290 BQ001808 AI021941 BM555447 BM670303

BQ423541 BF439717 AI888530 AI445301 AA476618 CA405733 BM754333 H99657

BQ424359 W63794 BE328713 CN480760 AW517692 BM686197 BI771420 CB120030

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TOMM20 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b
SP1:							-								-		-										-
SP2:							-
SP3:							-								-
SP4:							-						-		-		-		-		-						-
SP5:							-								-		-

ECgene alternative splicing isoforms for TOMM20

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TOMM20 expression in normal human tissues (normalized intensities) TOMM20 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CAGATAACAT

About this image

TOMM20 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/34 selected tissues (see all 34) fully expand


Epithelium
vagina ; squamous epithelial cells

Uterus
uterus, post-menopause ; glandular cells

Testis (Reproductive System) fully expand to see all 4 entries
Leydig Cells Testis Interstitium
seminal vesicle ; glandular cells

Colon (Gastrointestinal Tract) fully expand to see all 4 entries
colon ; peripheral nerve/ganglion

Brain (Nervous System) fully expand to see all 4 entries
Cerebral Cortex

See TOMM20 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TOMM20

SOURCE GeneReport for Unigene cluster: Hs.533192

SABiosciences Expression via Pathway-Focused PCR Array including TOMM20:

Mitochondria in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOMM20

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM20

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TOMM20 gene from 8/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tomm20^{1 , 5}	translocase of outer mitochondrial membrane 20 homolog (yeast) less^{1, 5}	92.18(n)¹ 99.31(a)¹		8 (74.64 cM)⁵ 67952¹ NM_024214.2¹ NP_077176.1¹ 126930664⁵
chicken (Gallus gallus)	Aves	TOMM20¹	translocase of outer mitochondrial membrane 20 homolog (yeast) less	85.98(n) 97.24(a)		426309 XM_423972.3 XP_423972.3
lizard (Anolis carolinensis)	Reptilia	TOMM20⁶	translocase of outer mitochondrial membrane 20 hom...	91(a)	1 ↔ 1	1(219649795-219660250)
African clawed frog (Xenopus laevis)	Amphibia	tomm20-pending-prov²	translocase of outer mitochondrial membrane 20 homolog (yeast) less	79.36(n)		BC041212.1
zebrafish (Danio rerio)	Actinopterygii	Dr.15589²	Transcribed sequence with moderate similarity to protein pirS66619 (H.sapiens) S66619 Mas 20 protein - human less	75.88(n)		CF595012.1
fruit fly (Drosophila melanogaster)	Insecta	Tom20¹	Translocase of outer membrane 20	58.54(n) 59.35(a)		40189 NM_140912.3 NP_649169.3
worm (Caenorhabditis elegans)	Secernentea	tomm-20¹	Protein TOMM-20	49.17(n) 43.26(a)		179691 NM_073691.4 NP_506092.1
wheat (Triticum aestivum)	Liliopsida	Ta.26866²	Triticum aestivum transcribed sequence with weak similarity to protein pirS66619 (H.sapiens) S66619 Mas 20 protein - human less	70.16(n)		CD491502.1

ENSEMBL Gene Tree for TOMM20 (if available)
TreeFam Gene Tree for TOMM20 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TOMM20 gene

TOMM20L²

1 SIMAP similar gene for TOMM20 using alignment to 1 protein entry: TOM20_HUMAN:

TOMM20L

TOMM20 for paralogs About GeneDecksing

5 Pseudogenes.org Pseudogenes for TOMM20
PGOHUM00000242811 PGOHUM00000237036 PGOHUM00000234849 PGOHUM00000232849 PGOHUM00000241843

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_052366⁴		--	--	see VAR_052366	2	P L	mis⁴		0	--	--	--	--
VAR_052367⁴		--	--	see VAR_052367	2	V L	mis⁴		0	--	--	--	--
rs1134889^1,2	C,F,H	--	235272186(-)	`TTGTAG/ATTTTG`	1	--	int¹		10		MN NS EA NA WA	936
rs75000312^1,2	C	--	235272200(+)	`CTCTC-/AT/TA AGATC`	1	--	int¹		0	--	--	--	--
rs7411516^1,2	C,F,H	--	235272357(+)	`ACAAGC/TCTTCA`	1	--	int¹		16		NS EA NA	1614
rs143454227^1,2	C	--	235272373(+)	`CGCACA/GTCAGC`	1	--	int¹		0	--	--	--	--
rs75027125^1,2	C,F	--	235272407(+)	`ACGAAC/TCTGTT`	1	--	int¹		1		WA	118
rs115669824^1,2	C,F	--	235272428(+)	`TCCCAG/AGTGAC`	1	--	int¹		1		WA	118
rs74490586^1,2	C,F	--	235272545(+)	`GGCAGG/AGAAGC`	1	--	int¹		1		WA	118
rs186098881^1,2		--	235272578(+)	`AGACGG/TTAACA`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TOMM20 (235272651 - 235292256 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for TOMM20: About this table

Variant ID	Type	Subtype	PubMed ID
esv275126	CNV	Loss	21479260
nsv508699	CNV	Loss	20534489

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 601848 OMIM disorders: --

2 diseases for TOMM20: About MalaCards

smallpox

TOMM20 for disorders About GeneDecksing

Genetic Association Database (GAD): TOMM20
Human Genome Epidemiology (HuGE) Navigator: TOMM20 (1 document)

Export disorders for TOMM20 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TOMM20 gene, integrated from 9 sources (see all 76):
(articles sorted by number of sources associating them with TOMM20)

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A human homolog of the mitochondrial protein import receptor Mom19 can assemble with the yeast mitochondrial receptor complex. (PubMed id 7498524)^{1, 2, 3} Seki N.... Pfanner N. (1995)
Identification of the human mitochondrial protein import receptor, huMas20p. Complementation of delta mas20 in yeast. (PubMed id 7589431)^{1, 2, 3} Goping I.S.... Shore G.C. (1995)
Gene structure of the human mitochondrial outer membrane receptor tom20 and evolutionary study of its family of processed pseudogenes. (PubMed id 10548729)^{1, 2, 9} Hernandez J.M.... Hernandez-Yago J. (1999)
Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)^{1, 4} Hendrickson S.L....O'Brien S.J. (2010)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20. (PubMed id 15733919)^{1, 3} Likic V.A....Lithgow T. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)^{1, 2} Nomura N.... Tabata S. (1994)
Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity. (PubMed id 14699115)^{1, 9} Yano M....Mori M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9804	HGNC: 20947	AceView: TOMM20	Ensembl:ENSG00000173726	euGenes: HUgn9804
ECgene: TOMM20	H-InvDB: TOMM20

(According to HUGE)
About This Section

HUGE: KIAA0016

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TOMM20	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TOMM20	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TOMM20 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TOMM20 gene:
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GeneCards and IP:
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TOMM20 Gene

Translocase Of Outer Mitochondrial Membrane 20 Homolog (Yeast)

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TOMM20 Gene

Translocase Of Outer Mitochondrial Membrane 20 Homolog (Yeast)

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