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Aliases for TOMM20 Gene

Aliases for TOMM20 Gene

  • Translocase Of Outer Mitochondrial Membrane 20 Homolog (Yeast) 2 3
  • Translocase Of Outer Mitochondrial Membrane 20 Homolog Type II 2 3
  • Mitochondrial 20 KDa Outer Membrane Protein 3 4
  • Outer Mitochondrial Membrane Receptor Tom20 3 4
  • Mitochondrial Import Receptor Subunit TOM20 Homolog 3
  • KIAA0016 4
  • MAS20 3
  • MOM19 3
  • TOM20 3

External Ids for TOMM20 Gene

Summaries for TOMM20 Gene

GeneCards Summary for TOMM20 Gene

TOMM20 (Translocase Of Outer Mitochondrial Membrane 20 Homolog (Yeast)) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Mitochondrial Protein Import. GO annotations related to this gene include unfolded protein binding and P-P-bond-hydrolysis-driven protein transmembrane transporter activity. An important paralog of this gene is TOMM20L.

UniProtKB/Swiss-Prot for TOMM20 Gene

  • Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).

Gene Wiki entry for TOMM20 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOMM20 Gene

Genomics for TOMM20 Gene

Genomic Location for TOMM20 Gene

Start:
235,109,336 bp from pter
End:
235,128,941 bp from pter
Size:
19,606 bases
Orientation:
Minus strand

Genomic View for TOMM20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TOMM20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOMM20 Gene

Regulatory Elements for TOMM20 Gene

Proteins for TOMM20 Gene

  • Protein details for TOMM20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15388-TOM20_HUMAN
    Recommended name:
    Mitochondrial import receptor subunit TOM20 homolog
    Protein Accession:
    Q15388
    Secondary Accessions:
    • A8K195
    • Q498B3
    • Q6IBT4

    Protein attributes for TOMM20 Gene

    Size:
    145 amino acids
    Molecular mass:
    16298 Da
    Quaternary structure:
    • Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with TOM22. Interacts with APEX1.

    Three dimensional structures from OCA and Proteopedia for TOMM20 Gene

neXtProt entry for TOMM20 Gene

Proteomics data for TOMM20 Gene at MOPED

Post-translational modifications for TOMM20 Gene

  • Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys56

Other Protein References for TOMM20 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TOMM20 Gene

Domains for TOMM20 Gene

Protein Domains for TOMM20 Gene

UniProtKB/Swiss-Prot:

TOM20_HUMAN
Family:
  • Belongs to the Tom20 family.:
    • Q15388
genes like me logo Genes that share domains with TOMM20: view

No data available for Gene Families for TOMM20 Gene

Function for TOMM20 Gene

Molecular function for TOMM20 Gene

UniProtKB/Swiss-Prot Function: Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).

Gene Ontology (GO) - Molecular Function for TOMM20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14557246
GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity IDA 14557246
GO:0051082 unfolded protein binding IDA 14557246
genes like me logo Genes that share ontologies with TOMM20: view

Phenotypes for TOMM20 Gene

GenomeRNAi human phenotypes for TOMM20:
genes like me logo Genes that share phenotypes with TOMM20: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TOMM20 Gene

Localization for TOMM20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOMM20 Gene

Mitochondrion outer membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TOMM20 Gene COMPARTMENTS Subcellular localization image for TOMM20 gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 2
endoplasmic reticulum 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TOMM20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005740 mitochondrial envelope --
GO:0005741 mitochondrial outer membrane --
GO:0005742 mitochondrial outer membrane translocase complex TAS 14557246
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TOMM20: view

Pathways for TOMM20 Gene

genes like me logo Genes that share pathways with TOMM20: view

Pathways by source for TOMM20 Gene

2 Reactome pathways for TOMM20 Gene

Gene Ontology (GO) - Biological Process for TOMM20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting --
GO:0006626 protein targeting to mitochondrion TAS --
GO:0006886 intracellular protein transport --
GO:0044267 cellular protein metabolic process TAS --
GO:0071806 protein transmembrane transport IDA 14557246
genes like me logo Genes that share ontologies with TOMM20: view

Compounds for TOMM20 Gene

(2) Novoseek inferred chemical compound relationships for TOMM20 Gene

Compound -log(P) Hits PubMed IDs
malate 35.3 1
atp 0 1
genes like me logo Genes that share compounds with TOMM20: view

Transcripts for TOMM20 Gene

mRNA/cDNA for TOMM20 Gene

Unigene Clusters for TOMM20 Gene

Translocase of outer mitochondrial membrane 20 homolog (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TOMM20 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b
SP1: - - - -
SP2: -
SP3: - -
SP4: - - - - - - -
SP5: - - -
SP6: - - -
SP7: - -

Relevant External Links for TOMM20 Gene

GeneLoc Exon Structure for
TOMM20
ECgene alternative splicing isoforms for
TOMM20

Expression for TOMM20 Gene

mRNA expression in normal human tissues for TOMM20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TOMM20 Gene

SOURCE GeneReport for Unigene cluster for TOMM20 Gene Hs.533192

genes like me logo Genes that share expressions with TOMM20: view

Orthologs for TOMM20 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TOMM20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOMM20 36
  • 99.54 (n)
  • 100 (a)
TOMM20 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TOMM20 36
  • 94.94 (n)
  • 100 (a)
TOMM20 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TOMM20 36
  • 94.25 (n)
  • 99.31 (a)
TOMM20 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tomm20 36
  • 92.18 (n)
  • 99.31 (a)
Tomm20 16
Tomm20 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TOMM20 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TOMM20 37
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tomm20 36
  • 91.95 (n)
  • 97.93 (a)
chicken
(Gallus gallus)
Aves TOMM20 36
  • 85.98 (n)
  • 97.24 (a)
TOMM20 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TOMM20 37
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia tomm20-pending-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11143 36
tomm20 36
  • 79.54 (n)
  • 88.97 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6481 36
zebrafish
(Danio rerio)
Actinopterygii Dr.15589 36
tomm20b 36
  • 74.94 (n)
  • 86.9 (a)
tomm20b 37
  • 50 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012339 36
  • 61.07 (n)
  • 59.2 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tom20 36
  • 58.6 (n)
  • 58.87 (a)
Tom20 37
  • 45 (a)
ManyToMany
tomboy20 37
  • 39 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea tomm-20 36
  • 49.17 (n)
  • 43.26 (a)
tomm-20 37
  • 33 (a)
OneToMany
wheat
(Triticum aestivum)
Liliopsida Ta.26866 36
Species with no ortholog for TOMM20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for TOMM20 Gene

ENSEMBL:
Gene Tree for TOMM20 (if available)
TreeFam:
Gene Tree for TOMM20 (if available)

Paralogs for TOMM20 Gene

Paralogs for TOMM20 Gene

Selected SIMAP similar genes for TOMM20 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TOMM20: view

Variants for TOMM20 Gene

Sequence variations from dbSNP and Humsavar for TOMM20 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7930 -- 235,109,879(-) AGAAC(A/G)AAAAA utr-variant-3-prime
rs11301 -- 235,109,864(-) CAGAT(C/T)TCAGT utr-variant-3-prime
rs1130651 -- 235,111,855(-) TCATT(C/T)TATAA utr-variant-3-prime
rs1130654 -- 235,111,816(-) GATTT(C/T)GTTTA utr-variant-3-prime
rs1134889 -- 235,108,871(-) TTGTA(A/G)TTTTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TOMM20 Gene

Variant ID Type Subtype PubMed ID
nsv508699 CNV Loss 20534489
esv275126 CNV Loss 21479260

Relevant External Links for TOMM20 Gene

HapMap Linkage Disequilibrium report
TOMM20

Disorders for TOMM20 Gene

Relevant External Links for TOMM20

Genetic Association Database (GAD)
TOMM20
Human Genome Epidemiology (HuGE) Navigator
TOMM20
genes like me logo Genes that share disorders with TOMM20: view

No data available for UniProtKB/Swiss-Prot for TOMM20 Gene

Publications for TOMM20 Gene

  1. Gene structure of the human mitochondrial outer membrane receptor tom20 and evolutionary study of its family of processed pseudogenes. (PMID: 10548729) Hernandez J.M. … Hernandez-Yago J. (Gene 1999) 3 4 23
  2. A human homolog of the mitochondrial protein import receptor Mom19 can assemble with the yeast mitochondrial receptor complex. (PMID: 7498524) Seki N. … Pfanner N. (FEBS Lett. 1995) 2 3 4
  3. Identification of the human mitochondrial protein import receptor, huMas20p. Complementation of delta mas20 in yeast. (PMID: 7589431) Goping I.S. … Shore G.C. (FEBS Lett. 1995) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20. (PMID: 15733919) LikiA8 V.A. … Lithgow T. (J. Mol. Biol. 2005) 2 3

Products for TOMM20 Gene

Sources for TOMM20 Gene

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