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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TOMM20 Gene

protein-coding   GIFtS: 63
GCID: GC01M235272

Translocase Of Outer Mitochondrial Membrane 20 Homolog (Yeast)

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Translocase Of Outer Mitochondrial Membrane 20 Homolog (Yeast)1 2     MOM192
Translocase Of Outer Mitochondrial Membrane 20 Homolog Type II1 2     TOM202
Mitochondrial 20 KDa Outer Membrane Protein2 3     Mitochondrial Import Receptor Subunit TOM20 Homolog2
Outer Mitochondrial Membrane Receptor Tom202 3     KIAA00163
MAS202     

External Ids:    HGNC: 209471   Entrez Gene: 98042   Ensembl: ENSG000001737267   OMIM: 6018485   UniProtKB: Q153883   

Export aliases for TOMM20 gene to outside databases

Previous GC identifers: GC00U913004 GC01M232313 GC01M231598 GC01M233339 GC01M205721


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TOMM20 Gene: 
TOMM20 (translocase of outer mitochondrial membrane 20 homolog (yeast)) is a protein-coding gene. Diseases associated with TOMM20 include smallpox, and among its related super-pathways are Post-translational protein modification. GO annotations related to this gene include unfolded protein binding and P-P-bond-hydrolysis-driven protein transmembrane transporter activity. An important paralog of this gene is TOMM20L.

UniProtKB/Swiss-Prot: TOM20_HUMAN, Q15388
Function: Central component of the receptor complex responsible for the recognition and translocation of
cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide
receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the
TOM40 translocation pore (By similarity)

Gene Wiki entry for TOMM20 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TOMM20 gene promoter:
         Pax-2   HNF-4alpha2   Pax-2a   NF-kappaB   YY1   HNF-4alpha1   GATA-1   AREB6   Pax-2b   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TOMM20

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOMM20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42   Ensembl cytogenetic band:  1q42.3   HGNC cytogenetic band: 1q42

TOMM20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOMM20 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M235272:  view genomic region     (about GC identifiers)

Start:
235,272,651 bp from pter      End:
235,292,256 bp from pter
Size:
19,606 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TOM20_HUMAN, Q15388 (See protein sequence)
Recommended Name: Mitochondrial import receptor subunit TOM20 homolog  
Size: 145 amino acids; 16298 Da
Subunit: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which
consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts
with TOM22. Interacts with APEX1
Subcellular location: Mitochondrion outer membrane; Single-pass membrane protein (Potential)
1 PDB 3D structure from and Proteopedia for TOMM20:
4APO (3D)    
Secondary accessions: A8K195 Q498B3 Q6IBT4

Explore the universe of human proteins at neXtProt for TOMM20: NX_Q15388

Explore proteomics data for TOMM20 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15388

  • TOMM20 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TOMM20 Protein Expression
    REFSEQ proteins: NP_055580.1  
    ENSEMBL proteins: 
     ENSP00000355566  
    Reactome Protein details: Q15388
    Human Recombinant Protein Products for TOMM20: 
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    OriGene Protein Over-expression Lysate for TOMM20
    OriGene MassSpec for TOMM20 
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    Novus Biologicals TOMM20 Proteins
    Novus Biologicals TOMM20 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TOMM20 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005740mitochondrial envelope ----
    GO:0005741mitochondrial outer membrane ----
    GO:0005742mitochondrial outer membrane translocase complex TAS14557246
    GO:0016021integral to membrane IEA--

    TOMM20 for ontologies           About GeneDecksing



    TOMM20 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for TOMM20 

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    Cloud-Clone Corp. ELISAs for TOMM20 
    Cloud-Clone Corp. CLIAs for TOMM20


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR022422 MAS20_rcpt_metazoan
     IPR023392 Tom20_dom
     IPR002056 MAS20_rcpt-related

    Graphical View of Domain Structure for InterPro Entry Q15388

    ProtoNet protein and cluster: Q15388

    1 Blocks protein domain: IPB002056 MAS20 protein import receptor signature

    UniProtKB/Swiss-Prot: TOM20_HUMAN, Q15388
    Similarity: Belongs to the Tom20 family


    TOMM20 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TOM20_HUMAN, Q15388
    Function: Central component of the receptor complex responsible for the recognition and translocation of
    cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide
    receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the
    TOM40 translocation pore (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14557246
    GO:0015450P-P-bond-hydrolysis-driven protein transmembrane transporter activity IDA14557246
    GO:0051082unfolded protein binding IDA14557246
         
    TOMM20 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TOMM20:
     Synthetic lethal with Ras 

         1 MGI phenotypic allele for Tomm20 (no phenotypes)

    TOMM20 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TOMM20 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TOMM20

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TOMM20 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TOMM20 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TOMM20
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate TOMM20 (see all 52):
    hsa-miR-548j hsa-miR-607 hsa-miR-4328 hsa-miR-15a hsa-miR-938 hsa-miR-424 hsa-miR-9 hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmidTOMM20 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Search LifeMap BioReagents cell lines for TOMM20
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM20


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TOMM20 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    2Mitochondrial Protein Import
    Mitochondrial Protein Import

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2        Reactome Pathways for TOMM20
        Mitochondrial Protein Import
    Metabolism of proteins



    TOMM20 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TOMM20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/64 Interacting proteins for TOMM20 (Q153882, 3 ENSP000003555664) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG6P463792, 3MINT-64241 I2D: score=5 
    ENSG00000096155P463792, 3MINT-64241 I2D: score=5 
    ENSG00000227761P463792, 3MINT-64241 I2D: score=5 
    ENSG00000228760P463792, 3MINT-64241 I2D: score=5 
    ENSG00000229524P463792, 3MINT-64241 I2D: score=5 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006605protein targeting ----
    GO:0006626protein targeting to mitochondrion TAS--
    GO:0006886intracellular protein transport ----
    GO:0044267cellular protein metabolic process TAS--

    TOMM20 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TOMM20 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TOMM20 (TOM20)

    2 Novoseek inferred chemical compound relationships for TOMM20 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    malate 35.3 1 11029287 (1)
    atp 0 1 9211931 (1)

    Search CenterWatch for drugs/clinical trials and news about TOMM20 / TOM20

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TOMM20 gene: 
    NM_014765.2  

    Unigene Cluster for TOMM20:

    Translocase of outer mitochondrial membrane 20 homolog (yeast)
    Hs.533192  [show with all ESTs]
    Unigene Representative Sequence: NM_014765
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366607(uc001hwl.3) ENST00000467767 ENST00000473132
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TOMM20
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate TOMM20 (see all 52):
    hsa-miR-548j hsa-miR-607 hsa-miR-4328 hsa-miR-15a hsa-miR-938 hsa-miR-424 hsa-miR-9 hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmidTOMM20 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM20
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOMM20
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOMM20

    Additional mRNA sequence: 

    AK289810.1 BC000882.1 BC009886.2 BC066335.1 BC071994.1 BC100286.1 BC107851.1 CR456718.1 
    D13641.1 

    24/33 DOTS entries (see all 33):

    DT.95163931  DT.95163927  DT.100684522  DT.121335406  DT.85105182  DT.101983019  DT.100848050  DT.100684523 
    DT.95163913  DT.100658026  DT.121335384  DT.91794195  DT.101975247  DT.121335441  DT.100664733  DT.100865287 
    DT.95163929  DT.100705173  DT.100732175  DT.100854094  DT.102835480  DT.121335442  DT.121335446  DT.207468 

    24/899 AceView cDNA sequences (see all 899):

    AA296605 BP383385 AW516234 AA702290 BQ001808 AI021941 BM555447 BM670303 
    BQ423541 BF439717 AI888530 AI445301 AA476618 CA405733 BM754333 H99657 
    BQ424359 W63794 BE328713 CN480760 AW517692 BM686197 BI771420 CB120030 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TOMM20 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b
    SP1:                    -                       -     -                             -               
    SP2:                    -                                                                           
    SP3:                    -                       -                                                   
    SP4:                    -                 -     -     -     -     -                 -               
    SP5:                    -                       -     -                                             


    ECgene alternative splicing isoforms for TOMM20

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TOMM20 expression in normal human tissues (normalized intensities)      TOMM20 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGATAACAT
    TOMM20 Expression
    About this image


    TOMM20 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See TOMM20 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TOMM20

    SOURCE GeneReport for Unigene cluster: Hs.533192
        SABiosciences Expression via Pathway-Focused PCR Array including TOMM20: 
              Mitochondria in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOMM20
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TOMM20 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tomm201 , 5 translocase of outer mitochondrial membrane 20 homolog more1, 5 92.18(n)1
    99.31(a)1
      8 (74.64 cM)5
    679521  NM_024214.21  NP_077176.11 
     1269306645 
    chicken
    (Gallus gallus)
    Aves TOMM201 translocase of outer mitochondrial membrane 20 homolog more 85.98(n)
    97.24(a)
      426309  XM_423972.3  XP_423972.3 
    lizard
    (Anolis carolinensis)
    Reptilia TOMM206
    translocase of outer mitochondrial membrane 20 hom...
    91(a)
    1 ↔ 1
    1(219649795-219660250)
    African clawed frog
    (Xenopus laevis)
    Amphibia tomm20-pending-prov2 translocase of outer mitochondrial membrane 20 homolog more 79.36(n)    BC041212.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.155892 Transcribed sequence with moderate similarity to protein more 75.88(n)    CF595012.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tom201 Translocase of outer membrane 20 58.54(n)
    59.35(a)
      40189  NM_140912.3  NP_649169.3 
    worm
    (Caenorhabditis elegans)
    Secernentea tomm-201 Protein TOMM-20 49.17(n)
    43.26(a)
      179691  NM_073691.4  NP_506092.1 
    wheat
    (Triticum aestivum)
    Liliopsida Ta.268662 Triticum aestivum transcribed sequence with weak similarity more 70.16(n)    CD491502.1 


    ENSEMBL Gene Tree for TOMM20 (if available)
    TreeFam Gene Tree for TOMM20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TOMM20 gene
    TOMM20L2  
    1 SIMAP similar gene for TOMM20 using alignment to 1 protein entry:     TOM20_HUMAN:
    TOMM20L

    TOMM20 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for TOMM20
    PGOHUM00000242811 PGOHUM00000237036 PGOHUM00000234849 PGOHUM00000232849 PGOHUM00000241843


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/406 SNPs in TOMM20 are shown (see all 406)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0523664
    ----see VAR_0523662 P L mis40--------
    VAR_0523674
    ----see VAR_0523672 V L mis40--------
    rs11348891,2
    C,F,H--235272186(-) TTGTAG/ATTTTG 1 -- int110Minor allele frequency- A:0.11MN NS EA NA WA 936
    rs750003121,2
    C--235272200(+) CTCTC-/AT/TA 
            
    AGATC
    1 -- int10--------
    rs74115161,2
    C,F,H--235272357(+) ACAAGC/TCTTCA 1 -- int116Minor allele frequency- T:0.07NS EA NA 1614
    rs1434542271,2
    C--235272373(+) CGCACA/GTCAGC 1 -- int10--------
    rs750271251,2
    C,F--235272407(+) ACGAAC/TCTGTT 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1156698241,2
    C,F--235272428(+) TCCCAG/AGTGAC 1 -- int11Minor allele frequency- A:0.06WA 118
    rs744905861,2
    C,F--235272545(+) GGCAGG/AGAAGC 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1860988811,2
    --235272578(+) AGACGG/TTAACA 1 -- int10--------

    HapMap Linkage Disequilibrium report for TOMM20 (235272651 - 235292256 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TOMM20:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv275126CNV Loss21479260
    nsv508699CNV Loss20534489

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601848    OMIM disorders: --

    2 diseases for TOMM20:    About MalaCards
    smallpox    


    TOMM20 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TOMM20
    Human Genome Epidemiology (HuGE) Navigator: TOMM20 (1 document)

    Export disorders for TOMM20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TOMM20 gene, integrated from 9 sources (see all 76):
    (articles sorted by number of sources associating them with TOMM20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human homolog of the mitochondrial protein import receptor Mom19 can assemble with the yeast mitochondrial receptor complex. (PubMed id 7498524)1, 2, 3 Seki N.... Pfanner N. (1995)
    2. Identification of the human mitochondrial protein import receptor, huMas20p. Complementation of delta mas20 in yeast. (PubMed id 7589431)1, 2, 3 Goping I.S.... Shore G.C. (1995)
    3. Gene structure of the human mitochondrial outer membrane receptor tom20 and evolutionary study of its family of processed pseudogenes. (PubMed id 10548729)1, 2, 9 Hernandez J.M.... Hernandez-Yago J. (1999)
    4. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20. (PubMed id 15733919)1, 3 Likic V.A....Lithgow T. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2 Nomura N.... Tabata S. (1994)
    10. Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity. (PubMed id 14699115)1, 9 Yano M....Mori M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9804 HGNC: 20947 AceView: TOMM20 Ensembl:ENSG00000173726 euGenes: HUgn9804
    ECgene: TOMM20 H-InvDB: TOMM20

    (According to HUGE)
    About This Section
    HUGE: KIAA0016

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TOMM20 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TOMM20 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TOMM20 gene:
    Search GeneIP for patents involving TOMM20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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