Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TOMM20 Gene

protein-coding   GIFtS: 65
GCID: GC01M235272

Translocase Of Outer Mitochondrial Membrane 20 Homolog (Yeast)

  Search for TOMM20
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Translocase Of Outer Mitochondrial Membrane 20 Homolog (Yeast)1 2     MOM192
Translocase Of Outer Mitochondrial Membrane 20 Homolog Type II1 2     TOM202
Mitochondrial 20 KDa Outer Membrane Protein2 3     Mitochondrial Import Receptor Subunit TOM20 Homolog2
Outer Mitochondrial Membrane Receptor Tom202 3     KIAA00163
MAS202     

External Ids:    HGNC: 209471   Entrez Gene: 98042   Ensembl: ENSG000001737267   OMIM: 6018485   UniProtKB: Q153883   

Export aliases for TOMM20 gene to outside databases

Previous GC identifers: GC00U913004 GC01M232313 GC01M231598 GC01M233339 GC01M205721


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for TOMM20 Gene:
TOMM20 (translocase of outer mitochondrial membrane 20 homolog (yeast)) is a protein-coding gene. GO annotations related to this gene include unfolded protein binding and P-P-bond-hydrolysis-driven protein transmembrane transporter activity. An important paralog of this gene is TOMM20L.

UniProtKB/Swiss-Prot: TOM20_HUMAN, Q15388
Function: Central component of the receptor complex responsible for the recognition and translocation of
cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide
receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the
TOM40 translocation pore (By similarity)

Gene Wiki entry for TOMM20 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TOMM20 gene promoter:
         Pax-2   HNF-4alpha2   Pax-2a   NF-kappaB   YY1   HNF-4alpha1   GATA-1   AREB6   Pax-2b   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TOMM20

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TOMM20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42   Ensembl cytogenetic band:  1q42.3   HGNC cytogenetic band: 1q42

TOMM20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOMM20 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M235272:  view genomic region     (about GC identifiers)

Start:
235,272,651 bp from pter      End:
235,292,256 bp from pter
Size:
19,606 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TOM20_HUMAN, Q15388 (See protein sequence)
Recommended Name: Mitochondrial import receptor subunit TOM20 homolog  
Size: 145 amino acids; 16298 Da
Subunit: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which
consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts
with TOM22. Interacts with APEX1
1 PDB 3D structure from and Proteopedia for TOMM20:
4APO (3D)    
Secondary accessions: A8K195 Q498B3 Q6IBT4

Explore the universe of human proteins at neXtProt for TOMM20: NX_Q15388

Explore proteomics data for TOMM20 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys56
  • Modification sites at PhosphoSitePlus

  • See TOMM20 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055580.1  
    ENSEMBL proteins: 
     ENSP00000355566  
    Reactome Protein details: Q15388

    TOMM20 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TOMM20
    OriGene Protein Over-expression Lysate for TOMM20
    OriGene MassSpec for TOMM20
    OriGene Custom Protein Services for TOMM20
    GenScript Custom Purified and Recombinant Proteins Services for TOMM20
    Novus Biologicals TOMM20 Proteins
    Novus Biologicals TOMM20 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TOMM20
    Cloud-Clone Corp. Proteins for TOMM20

     
    Search eBioscience for Proteins for TOMM20 

    TOMM20 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TOMM20
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TOMM20
    OriGene Custom Antibody Services for TOMM20
    Novus Biologicals TOMM20 Antibodies
    Abcam antibodies for TOMM20
    Cloud-Clone Corp. Antibodies for TOMM20
    Search ThermoFisher Antibodies for TOMM20
    LSBio Antibodies in human, mouse, rat for TOMM20

    TOMM20 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TOMM20
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TOMM20
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TOMM20
    Cloud-Clone Corp. CLIAs for TOMM20
    Search eBioscience for ELISAs for TOMM20 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR022422 MAS20_rcpt_metazoan
     IPR023392 Tom20_dom
     IPR002056 MAS20_rcpt-related

    Graphical View of Domain Structure for InterPro Entry Q15388

    ProtoNet protein and cluster: Q15388

    1 Blocks protein domain: IPB002056 MAS20 protein import receptor signature

    UniProtKB/Swiss-Prot: TOM20_HUMAN, Q15388
    Similarity: Belongs to the Tom20 family


    Find genes that share domains with TOMM20           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TOM20_HUMAN, Q15388
    Function: Central component of the receptor complex responsible for the recognition and translocation of
    cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide
    receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the
    TOM40 translocation pore (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14557246
    GO:0015450P-P-bond-hydrolysis-driven protein transmembrane transporter activity IDA14557246
    GO:0051082unfolded protein binding IDA14557246
         
    Find genes that share ontologies with TOMM20           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TOMM20:
     Synthetic lethal with Ras 

         1 MGI phenotypic allele for Tomm20 (no phenotypes)

    Find genes that share phenotypes with TOMM20           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TOMM20
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TOMM20

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TOMM20
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TOMM20

    miRNA
    Products:
        
    miRTarBase miRNAs that target TOMM20:
    hsa-let-7d-5p (MIRT032124), hsa-mir-221-3p (MIRT024153), hsa-mir-93-3p (MIRT038775), hsa-mir-155-5p (MIRT020995), hsa-mir-331-3p (MIRT043268), hsa-mir-503-5p (MIRT041097), hsa-mir-20a-5p (MIRT050518)

    Block miRNA regulation of human, mouse, rat TOMM20 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TOMM20 (see all 52):
    hsa-miR-548j hsa-miR-607 hsa-miR-4328 hsa-miR-15a hsa-miR-938 hsa-miR-424 hsa-miR-9 hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmidTOMM20 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TOMM20
    Predesigned siRNA for gene silencing in human, mouse, rat TOMM20

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TOMM20

    Clone
    Products:
         
    OriGene clones in human, mouse for TOMM20 (see all 6)
    OriGene ORF clones in mouse, rat for TOMM20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TOMM20 (NM_014765)
    Sino Biological Human cDNA Clone for TOMM20
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOMM20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM20
    Addgene plasmids for TOMM20 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TOMM20
    Browse ESI BIO Cell Lines and PureStem Progenitors for TOMM20 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM20


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TOM20_HUMAN, Q15388: Mitochondrion outer membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    extracellular2
    endoplasmic reticulum1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005740mitochondrial envelope ----
    GO:0005741mitochondrial outer membrane ----
    GO:0005742mitochondrial outer membrane translocase complex TAS14557246
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TOMM20           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TOMM20 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    2Mitochondrial Protein Import
    Mitochondrial Protein Import


    Find genes that share SuperPaths with TOMM20           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for TOMM20
        Mitochondrial protein import


        Pathway & Disease-focused RT2 Profiler PCR Array including TOMM20: 
              Mitochondria in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TOMM20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TOMM20 (Q153882, 3 ENSP000003555664) via UniProtKB, MINT, STRING, and/or I2D (see all 75)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG6P463792, 3MINT-64241 I2D: score=5 
    ENSG00000096155P463792, 3MINT-64241 I2D: score=5 
    ENSG00000227761P463792, 3MINT-64241 I2D: score=5 
    ENSG00000228760P463792, 3MINT-64241 I2D: score=5 
    ENSG00000229524P463792, 3MINT-64241 I2D: score=5 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006605protein targeting ----
    GO:0006626protein targeting to mitochondrion TAS--
    GO:0006886intracellular protein transport ----
    GO:0044267cellular protein metabolic process TAS--
    GO:0071806protein transmembrane transport IDA14557246

    Find genes that share ontologies with TOMM20           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TOMM20 (TOM20)

    2 Novoseek inferred chemical compound relationships for TOMM20 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    malate 35.3 1 11029287 (1)
    atp 0 1 9211931 (1)



    Find genes that share compounds with TOMM20           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TOMM20 gene: 
    NM_014765.2  

    Unigene Cluster for TOMM20:

    Translocase of outer mitochondrial membrane 20 homolog (yeast)
    Hs.533192  [show with all ESTs]
    Unigene Representative Sequence: NM_014765
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366607(uc001hwl.3) ENST00000467767 ENST00000473132
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TOMM20 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TOMM20 (see all 52):
    hsa-miR-548j hsa-miR-607 hsa-miR-4328 hsa-miR-15a hsa-miR-938 hsa-miR-424 hsa-miR-9 hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmidTOMM20 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TOMM20
    Predesigned siRNA for gene silencing in human, mouse, rat TOMM20
    Clone
    Products:
         
    OriGene clones in human, mouse for TOMM20 (see all 6)
    OriGene ORF clones in mouse, rat for TOMM20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TOMM20 (NM_014765)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOMM20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM20
    Addgene plasmids for TOMM20 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TOMM20
    OriGene qSTAR qPCR primer pairs in human, mouse for TOMM20
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TOMM20
      QuantiTect SYBR Green Assays in human, mouse, rat TOMM20
      QuantiFast Probe-based Assays in human, mouse, rat TOMM20

    Additional mRNA sequence: 

    AK289810.1 BC000882.1 BC009886.2 BC066335.1 BC071994.1 BC100286.1 BC107851.1 CR456718.1 
    D13641.1 

    Selected DOTS entries (see all 33):

    DT.95163931  DT.95163927  DT.100684522  DT.121335406  DT.85105182  DT.101983019  DT.100848050  DT.100684523 
    DT.95163913  DT.100658026  DT.121335384  DT.91794195  DT.101975247  DT.121335441  DT.100664733  DT.100865287 
    DT.95163929  DT.100705173  DT.100732175  DT.100854094  DT.102835480  DT.121335442  DT.121335446  DT.207468 

    Selected AceView cDNA sequences (see all 899):

    AA724567 H99657 CB177879 AU128188 CD677576 AI203601 BU624747 NM_014765 
    AU120547 AA644550 AI284088 BM555447 AA634684 BU838445 BQ649285 BE350613 
    AI050868 BQ417009 AW002024 BF346299 BQ717850 BU181897 BQ416810 BP430526 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TOMM20 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b
    SP1:                    -                       -     -                             -               
    SP2:                    -                                                                           
    SP3:                    -                       -                                                   
    SP4:                    -                 -     -     -     -     -                 -               
    SP5:                    -                       -     -                                             


    ECgene alternative splicing isoforms for TOMM20

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TOMM20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGATAACAT
    TOMM20 Expression
    About this image


    TOMM20 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    TOMM20 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TOMM20 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.533192
        Pathway & Disease-focused RT2 Profiler PCR Array including TOMM20: 
              Mitochondria in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TOMM20
    OriGene qSTAR qPCR primer pairs in human, mouse for TOMM20
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TOMM20
    QuantiTect SYBR Green Assays in human, mouse, rat TOMM20
    QuantiFast Probe-based Assays in human, mouse, rat TOMM20
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TOMM20 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tomm201 , 5 translocase of outer mitochondrial membrane 20 homolog more1, 5 92.18(n)1
    99.31(a)1
      8 (74.64 cM)5
    679521  NM_024214.21  NP_077176.11 
     1269306645 
    chicken
    (Gallus gallus)
    Aves TOMM201 translocase of outer mitochondrial membrane 20 homolog more 85.98(n)
    97.24(a)
      426309  XM_423972.4  XP_423972.3 
    lizard
    (Anolis carolinensis)
    Reptilia TOMM206
    translocase of outer mitochondrial membrane 20 hom...
    92(a)
    1 ↔ 1
    1(219649795-219660250)
    African clawed frog
    (Xenopus laevis)
    Amphibia tomm20-pending-prov2 translocase of outer mitochondrial membrane 20 homolog more 79.36(n)    BC041212.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.155892 Transcribed sequence with moderate similarity to protein more 75.88(n)    CF595012.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tom201 Translocase of outer membrane 20 58.6(n)
    58.87(a)
      40189  NM_001275156.1  NP_001262085.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tomm-201 tomm-20 49.17(n)
    43.26(a)
      179691  NM_073691.5  NP_506092.1 
    wheat
    (Triticum aestivum)
    Liliopsida Ta.268662 Triticum aestivum transcribed sequence with weak similarity more 70.16(n)    CD491502.1 


    ENSEMBL Gene Tree for TOMM20 (if available)
    TreeFam Gene Tree for TOMM20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TOMM20 gene
    TOMM20L2  
    1 SIMAP similar gene for TOMM20 using alignment to 1 protein entry:     TOM20_HUMAN:
    TOMM20L

    Find genes that share paralogs with TOMM20           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for TOMM20
    PGOHUM00000242811 PGOHUM00000237036 PGOHUM00000234849 PGOHUM00000232849 PGOHUM00000241843


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TOMM20 (see all 406)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs11348891,2
    C,F,H--235272186(-) TTGTAG/ATTTTG 1 -- int110Minor allele frequency- A:0.11MN NS EA NA WA 936
    rs750003121,2
    C--235272200(+) CTCTC-/AT/TA 
            
    AGATC
    1 -- int10--------
    rs74115161,2
    C,F,H--235272357(+) ACAAGC/TCTTCA 1 -- int116Minor allele frequency- T:0.07NS EA NA 1614
    rs1434542271,2
    C--235272373(+) CGCACA/GTCAGC 1 -- int10--------
    rs750271251,2
    C,F--235272407(+) ACGAAC/TCTGTT 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1156698241,2
    C,F--235272428(+) TCCCAG/AGTGAC 1 -- int11Minor allele frequency- A:0.06WA 118
    rs744905861,2
    C,F--235272545(+) GGCAGG/AGAAGC 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1860988811,2
    --235272578(+) AGACGG/TTAACA 1 -- int10--------
    rs1906255291,2
    --235272725(+) TTTTAC/TGTTAC 1 -- ut310--------
    rs1833355131,2
    --235272892(+) CAAACA/GTTTAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TOMM20 (235272651 - 235292256 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TOMM20:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv275126CNV Loss21479260
    nsv508699CNV Loss20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TOMM20
    DNA2.0 Custom Variant and Variant Library Synthesis for TOMM20

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601848    OMIM disorders: --


    Find genes that share disorders with TOMM20           About GenesLikeMe

    Genetic Association Database (GAD): TOMM20
    Human Genome Epidemiology (HuGE) Navigator: TOMM20 (1 document)

    Export disorders for TOMM20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TOMM20 gene, integrated from 10 sources (see all 77):
    (articles sorted by number of sources associating them with TOMM20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human homolog of the mitochondrial protein import receptor Mom19 can assemble with the yeast mitochondrial receptor complex. (PubMed id 7498524)1, 2, 3 Seki N.... Pfanner N. (FEBS Lett. 1995)
    2. Identification of the human mitochondrial protein import receptor, huMas20p. Complementation of delta mas20 in yeast. (PubMed id 7589431)1, 2, 3 Goping I.S.... Shore G.C. (FEBS Lett. 1995)
    3. Gene structure of the human mitochondrial outer membrane receptor tom20 and evolutionary study of its family of processed pseudogenes. (PubMed id 10548729)1, 2, 9 Hernandez J.M.... Hernandez-Yago J. (Gene 1999)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20. (PubMed id 15733919)1, 3 LikiA8 V.A....Lithgow T. (J. Mol. Biol. 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2 Nomura N.... Tabata S. (DNA Res. 1994)
    10. Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity. (PubMed id 14699115)1, 9 Yano M....Mori M. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9804 HGNC: 20947 AceView: TOMM20 Ensembl:ENSG00000173726 euGenes: HUgn9804
    ECgene: TOMM20 H-InvDB: TOMM20

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0016

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TOMM20 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TOMM20 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TOMM20 gene:
    Search GeneIP for patents involving TOMM20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of TOMM20
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TOMM20   OriGene RNAi products in human, mouse, rat for TOMM20  
     OriGene qPCR primer pairs and template standards for TOMM20   OriGene Protein Over-expression Lysate for TOMM20  
     OriGene MassSpec something-or-other for TOMM20   OriGene clones in human, mouse for TOMM20  
     OriGene qSTAR qPCR primer pairs in human, mouse for TOMM20   OriGene Purified Protein for TOMM20  
     OriGene ORF clones in mouse, rat for TOMM20   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TOMM20   OriGene Custom Protein Services for TOMM20  

     
     
     Block miRNA regulation of human, mouse, rat TOMM20 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TOMM20
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TOMM20 Predesigned siRNA for gene silencing in human, mouse, rat TOMM20
     QuantiFast Probe-based Assays in human, mouse, rat TOMM20 QuantiTect SYBR Green Assays in human, mouse, rat TOMM20
     PCR Arrays including human, mouse, rat TOMM20 Search Chromatin IP Primers for TOMM20
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TOMM20  GeneGlobe Interaction Network for TOMM20
     Regulatory tfbs in TOMM20 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TOMM20 GenScript cDNA clones with any tag delivered in your preferred vector for TOMM20
     GenScript Custom Assay Services for TOMM20 GenScript Custom overexpressing Cell Line Services for TOMM20
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TOMM20 (TOM20)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for TOMM20
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TOMM20 antibodies
     TOMM20 proteins
     TOMM20 lysates
     Antibodies for TOMM20
     See all of Abcam's Antibodies, Kits and Proteins for TOMM20
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for TOMM20
     Proteins for TOMM20
     Antibodies for TOMM20
     ELISAs for TOMM20
     CLIAs for TOMM20



     Browse ESI BIO Cell Lines and PureStem Progenitors for TOMM20
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM20
     SwitchGear 3'UTR luciferase reporter plasmids for TOMM20
     Browse SwitchGear Promoter luciferase reporter plasmids for TOMM20
     Search ThermoFisher Antibodies for TOMM20
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM20
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TOMM20
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TOMM20
     LSBio Antibodies in human, mouse, rat for TOMM20
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for TOMM20
      Search eBioscience for proteins for TOMM20
      Search eBioscience for elisas for TOMM20
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TOMM20 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4