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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TOMM20 Gene

protein-coding   GIFtS: 57
GCID: GC01M235272

translocase of outer mitochondrial membrane 20 homolog (yeast)
 Explore 1 disease affiliated with
TOMM20 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TOMM20    

Aliases
for TOMM20 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Translocase Of Outer Mitochondrial Membrane 20 Homolog (Yeast)1 2     Mitochondrial 20 KDa Outer Membrane Protein2 3
MAS201 2     Outer Mitochondrial Membrane Receptor Tom202 3
MOM191 2     Mitochondrial Import Receptor Subunit TOM20 Homolog2
TOM201 2     Translocase Of Outer Mitochondrial Membrane 20 Homolog Type II2
KIAA00161 3     

External Ids:    HGNC: 209471   Entrez Gene: 98042   Ensembl: ENSG000001737267   OMIM: 6018485   UniProtKB: Q153883   

Export aliases for TOMM20 gene to outside databases

Previous GC identifers: GC00U913004 GC01M232313 GC01M231598 GC01M233339 GC01M205721


Summaries
for TOMM20 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TOM20_HUMAN, Q15388
Function: Central component of the receptor complex responsible for the recognition and translocation of cytosolically
synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of
the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By
similarity)

Gene Wiki entry for TOMM20


Genomic Views
for TOMM20 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TOMM20 gene promoter:
         Pax-2   HNF-4alpha2   Pax-2a   NF-kappaB   YY1   HNF-4alpha1   GATA-1   AREB6   Pax-2b   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TOMM20

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOMM20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42   Ensembl cytogenetic band:  1q42.3   HGNC cytogenetic band: 1q42

TOMM20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOMM20 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M235272:  view genomic region     (about GC identifiers)

Start:
 235,272,651 bp from pter      End:
 235,292,256 bp from pter
Size:
 19,606 bases      Orientation:
 minus strand

Proteins
for TOMM20 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TOM20_HUMAN, Q15388 (See protein sequence)
Recommended Name: Mitochondrial import receptor subunit TOM20 homolog  
Size: 145 amino acids; 16298 Da
Subunit: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which
consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with
TOM22. Interacts with APEX1
Subcellular location: Mitochondrion outer membrane; Single-pass membrane protein (Potential)
1 PDB 3D structure from and Proteopedia for TOMM20:
4APO (3D)    
Secondary accessions: A8K195 Q498B3 Q6IBT4

Explore the universe of human proteins at neXtProt for TOMM20: NX_Q15388

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15388

    • TOMM20 Protein expression data from MOPED and PaxDb:    About this image 
    TOMM20 Protein Expression
    REFSEQ proteins: NP_055580.1  
    ENSEMBL proteins: 
     ENSP00000355566  
    Reactome Protein details: Q15388
    Human Recombinant Protein Products for TOMM20: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate: TOMM20
    OriGene Custom Protein Services for TOMM20 
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    Novus Biologicals TOMM20 Protein
    Novus Biologicals TOMM20 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TOMM20

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005740mitochondrial envelope ----
    GO:0005742mitochondrial outer membrane translocase complex TAS15644312
    GO:0016021integral to membrane IEA--

    TOMM20 for ontologies           About GeneDecksing



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    Assay Products for TOMM20: 
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    Uscn ELISAs and CLIAs for TOMM20

    Protein Domains /
    Families
    for TOMM20 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TOMM20 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR022422 MAS20_rcpt_metazoan
     IPR023392 Tom20_dom
     IPR002056 MAS20_rcpt-related

    Graphical View of Domain Structure for InterPro Entry Q15388

    ProtoNet protein and cluster: Q15388

    1 Blocks protein family: IPB002056 MAS20 protein import receptor signature

    UniProtKB/Swiss-Prot: TOM20_HUMAN, Q15388
    Similarity: Belongs to the Tom20 family


    Function
    for TOMM20 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TOM20_HUMAN, Q15388
    Function: Central component of the receptor complex responsible for the recognition and translocation of cytosolically
    synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of
    the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By
    similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14557246
    GO:0015450P-P-bond-hydrolysis-driven protein transmembrane transporter activity IDA14557246
    GO:0051082unfolded protein binding IDA14557246
         
    TOMM20 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TOMM20:
     Synthetic lethal with Ras 

         1 MGI phenotypic allele for Tomm20 (no phenotypes)

    TOMM20 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TOMM20 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: TOMM20
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TOMM20
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate TOMM20 (see all 52):
    hsa-miR-548j hsa-miR-607 hsa-miR-4328 hsa-miR-15a hsa-miR-938 hsa-miR-424 hsa-miR-9 hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmid: TOMM20 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TOMM20 (see all 7)
    OriGene shRNA RFP: TOMM20
    Browse OriGene siRNA
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    Sirion Biotech Custom design and validation of potent shRNA sequences against TOMM20 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TOMM20
    Sirion Biotech Customized adenovirus for overexpression of TOMM20 
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM20 (see all 3)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM20 

    Cell Line
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    Search LifeMap BioReagents cell lines for TOMM20
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOMM20


    Pathways & Interactions
    for TOMM20 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Mitochondrial Protein Import
    		Mitochondrial Protein Import1.00
    2Asparagine N-linked glycosylation
    		Metabolism of proteins0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for TOMM20
        Mitochondrial Protein Import
    Metabolism of proteins



    TOMM20 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TOMM20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/58 Interacting proteins for TOMM20 (Q153882, 3 ENSP000003555664) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PINK1Q9BXM72, 3, ENSP000003642044MINT-7557121 MINT-7557138 I2D: score=1 STRING: ENSP00000364204
    BAXQ078122, 3, ENSP000002932884MINT-7948915 I2D: score=1 STRING: ENSP00000293288
    APOA1P026472, 3MINT-64236 I2D: score=5 
    BAG6P463792, 3MINT-64241 I2D: score=5 
    FEZ1Q996892, 3MINT-64240 I2D: score=5 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion TAS--
    GO:0044267cellular protein metabolic process TAS--

    TOMM20 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TOMM20 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TOMM20 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TOMM20
    2 Novoseek chemical compound relationships for TOMM20 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    malate 35.3 1 11029287 (1)
    atp 0 1 9211931 (1)

    Search CenterWatch for drugs/clinical trials and news about TOMM20 / TOM20 

    Transcripts
    for TOMM20 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TOMM20 gene: 
    NM_014765.2  

    Unigene Cluster for TOMM20:

    Translocase of outer mitochondrial membrane 20 homolog (yeast)
    Hs.533192  [show with all ESTs]
    Unigene Representative Sequence: NM_014765
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366607(uc001hwl.3) ENST00000467767 ENST00000473132

    miRNA
    Products:             		 OriGene 3'-UTR Clone: TOMM20
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TOMM20
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate TOMM20 (see all 52):
    hsa-miR-548j hsa-miR-607 hsa-miR-4328 hsa-miR-15a hsa-miR-938 hsa-miR-424 hsa-miR-9 hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmid: TOMM20 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TOMM20 (see all 7)
    OriGene shRNA RFP: TOMM20
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOMM20
    Sirion Biotech Custom design and validation of potent shRNA sequences against TOMM20 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOMM20
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    GenScript: all cDNA clones in your preferred vector: TOMM20 (NM_014765)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOMM20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOMM20 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TOMM20
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOMM20
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOMM20

    Additional cDNA sequence: 

    AK289810.1 BC000882.1 BC009886.2 BC066335.1 BC071994.1 BC100286.1 BC107851.1 CR456718.1 
    D13641.1 

    24/31 DOTS entries (see all 31):

    DT.95163931  DT.95163927  DT.100684522  DT.121335406  DT.85105182  DT.101983019  DT.100848050  DT.95163913 
    DT.100684523  DT.100658026  DT.121335384  DT.91794195  DT.121335441  DT.100664733  DT.100865287  DT.95163929 
    DT.100732175  DT.100854094  DT.101975247  DT.102835480  DT.121335442  DT.121335446  DT.207468  DT.95208000 

    24/899 AceView cDNA sequences (see all 899):

    AA130639 BM968080 BM785821 CD677576 AA669930 BF794279 CA311013 AI307157 
    BE774587 AW082401 AI348201 BP342883 CR620459 AI203601 AI017410 AW516234 
    AW072695 AI284088 AW316895 BF346299 CD518033 CR598588 AI445227 AW188312 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TOMM20 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b
    SP1:                    -                       -     -                             -               
    SP2:                    -                                                                           
    SP3:                    -                       -                                                   
    SP4:                    -                 -     -     -     -     -                 -               
    SP5:                    -                       -     -                                             


    ECgene alternative splicing isoforms for TOMM20

    Expression
    for TOMM20 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TOMM20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGATAACAT
    TOMM20 Expression
    About this image

    TOMM20 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TOMM20 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TOMM20

    SOURCE GeneReport for Unigene cluster: Hs.533192
        SABiosciences Expression via Pathway-Focused PCR Array including TOMM20: 
              Mitochondria in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for TOMM20 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TOMM20 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TOMM201 translocase of outer mitochondrial membrane 20 homolog more 85.98(n)
    97.24(a)    		   426309  XM_423972.3  XP_423972.3 
    African clawed frog
    (Xenopus laevis)    		 Amphibia tomm20-pending-prov2 translocase of outer mitochondrial membrane 20 homolog more 79.36(n)    BC041212.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.155892 Transcribed sequence with moderate similarity to protein more 75.88(n)    CF595012.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Tom201 Translocase of outer membrane 20 58.54(n)
    59.35(a)    		   40189  NM_140912.3  NP_649169.3 
    worm
    (Caenorhabditis elegans)    		 Secernentea tomm-201 Protein TOMM-20 49.17(n)
    43.26(a)    		   179691  NM_073691.4  NP_506092.1 
    wheat
    (Triticum aestivum)    		 Liliopsida Ta.268662 Triticum aestivum transcribed sequence with weak similarity more 70.16(n)    CD491502.1 


    ENSEMBL Gene Tree for TOMM20 (if available)
    TreeFam Gene Tree for TOMM20 (if available) 

    Paralogs
    for TOMM20 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TOMM20 gene
    TOMM20L2  
    1 SIMAP similar gene for TOMM20 using alignment to 1 protein entry:     TOM20_HUMAN:
    TOMM20L

    TOMM20 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for TOMM20
    PGOHUM00000242811 PGOHUM00000237036 PGOHUM00000234849 PGOHUM00000232849 PGOHUM00000241843


    Genomic Variants
    for TOMM20 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/354 NCBI SNPs in TOMM20 are shown (see all 354)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs11348891,2
    		C,F,H--235272186(-) TTGTAG/ATTTTG 1 -- int110Minor allele frequency- A:0.11MN NS EA NA WA 936
    rs2006123051,2
    		C--235272200(+) CTCTC-/ATAGATC 1 -- int10--------
    rs74115161,2
    		C,F,H--235272357(+) ACAAGC/TCNNNN 1 -- int116Minor allele frequency- T:0.07NS EA NA 1614
    rs1434542271,2
    		--235272373(+) CGCACA/GTCAGC 1 -- int10--------
    rs750271251,2
    		F--235272407(+) ACGAAC/TCTGTT 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1156698241,2
    		F--235272428(+) TCCCAG/AGTGAC 1 -- int11Minor allele frequency- A:0.06WA 118
    rs744905861,2
    		C,F--235272545(+) GGCAGG/AGAAGC 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1860988811,2
    		--235272578(+) AGACGG/TTAACA 1 -- int10--------
    rs1906255291,2
    		--235272725(+) TTTTAC/TGTTAC 1 -- ut310--------
    rs1833355131,2
    		--235272892(+) CAAACA/GTTTAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TOMM20 (235272651 - 235292256 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TOMM20: --

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    Disorders / Diseases
    for TOMM20 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TOMM20 for disorders           About GeneDecksing

    OMIM gene information: 601848    OMIM disorders: --

    1 disease for TOMM20:    About MalaCards
    cholesterol

    Human Genome Epidemiology (HuGE) Navigator: TOMM20 (1 document)

    Export disorders for TOMM20 gene to outside databases

    Publications
    for TOMM20 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TOMM20 gene, integrated from 9 sources (see all 70):
    (articles sorted by number of sources associating them with TOMM20)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A human homolog of the mitochondrial protein import receptor Mom19 can assemble with the yeast mitochondrial receptor complex. (PubMed id 7498524)1, 2, 3 Seki N.... Pfanner N. (1995)
    2. Identification of the human mitochondrial protein import receptor, huMas20p. Complementation of delta mas20 in yeast. (PubMed id 7589431)1, 2, 3 Goping I.S.... Shore G.C. (1995)
    3. Gene structure of the human mitochondrial outer membrane receptor tom20 and evolutionary study of its family of processed pseudogenes. (PubMed id 10548729)1, 2, 9 Hernandez J.M.... Hernandez-Yago J. (1999)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20. (PubMed id 15733919)1, 3 Likic V.A....Lithgow T. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2 Nomura N.... Tabata S. (1994)
    9. Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity. (PubMed id 14699115)1, 9 Yano M....Mori M. (2004)
    10. Functional analysis of human metaxin in mitochondrial protein import in cultured cells and its relationship with the Tom complex. (PubMed id 11027586)1, 9 Abdul K.M....Mori M. (2000)

    External Searches for TOMM20 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TOMM20 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9804 HGNC: 20947 AceView: TOMM20 Ensembl:ENSG00000173726 euGenes: HUgn9804
    ECgene: TOMM20 H-InvDB: TOMM20

    Other Databases showing TOMM20 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0016

    Specialized Databases showing TOMM20 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TOMM20 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TOMM20 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TOMM20 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TOMM20 gene:
    Search GeneIP for patents involving TOMM20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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