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Aliases for TOM1L2 Gene

Aliases for TOM1L2 Gene

  • Target Of Myb1 Like 2 Membrane Trafficking Protein 2 3 5
  • Target Of Myb1 (Chicken) Homolog-Like 1 2
  • Target Of Myb1-Like 2 (Chicken) 2
  • Target Of Myb-Like Protein 2 4

External Ids for TOM1L2 Gene

Previous GeneCards Identifiers for TOM1L2 Gene

  • GC17U990153
  • GC17M017693
  • GC17M017950
  • GC17M017691
  • GC17M017688
  • GC17M017746
  • GC17M017500

Summaries for TOM1L2 Gene

GeneCards Summary for TOM1L2 Gene

TOM1L2 (Target Of Myb1 Like 2 Membrane Trafficking Protein) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding and clathrin binding. An important paralog of this gene is TOM1L1.

UniProtKB/Swiss-Prot for TOM1L2 Gene

  • Probable role in protein transport. May regulate growth factor-induced mitogenic signaling.

Gene Wiki entry for TOM1L2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOM1L2 Gene

Genomics for TOM1L2 Gene

Regulatory Elements for TOM1L2 Gene

Promoters for TOM1L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TOM1L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TOM1L2 Gene

Chromosome:
17
Start:
17,843,508 bp from pter
End:
17,972,470 bp from pter
Size:
128,963 bases
Orientation:
Minus strand

Genomic View for TOM1L2 Gene

Genes around TOM1L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOM1L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOM1L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOM1L2 Gene

Proteins for TOM1L2 Gene

  • Protein details for TOM1L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZVM7-TM1L2_HUMAN
    Recommended name:
    TOM1-like protein 2
    Protein Accession:
    Q6ZVM7
    Secondary Accessions:
    • B7Z2L7
    • B7Z7F4
    • Q86V61
    • Q8TDE7
    • Q96M88

    Protein attributes for TOM1L2 Gene

    Size:
    507 amino acids
    Molecular mass:
    55556 Da
    Quaternary structure:
    • Interacts with clathrin, SRC and TOLLIP.
    SequenceCaution:
    • Sequence=AAL78338.1; Type=Frameshift; Positions=101, 121, 170; Evidence={ECO:0000305};

    Alternative splice isoforms for TOM1L2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TOM1L2 Gene

Proteomics data for TOM1L2 Gene at MOPED

Post-translational modifications for TOM1L2 Gene

  • Ubiquitination at Lys 101, Lys 106, Lys 145, Lys 400, and Lys 462
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for TOM1L2 Gene

Domains & Families for TOM1L2 Gene

Protein Domains for TOM1L2 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZVM7

UniProtKB/Swiss-Prot:

TM1L2_HUMAN :
  • The GAT domain mediates interaction with TOLLIP.
  • Belongs to the TOM1 family.
Domain:
  • The GAT domain mediates interaction with TOLLIP.
  • Contains 1 GAT domain.
  • Contains 1 VHS domain.
Family:
  • Belongs to the TOM1 family.
genes like me logo Genes that share domains with TOM1L2: view

No data available for Gene Families for TOM1L2 Gene

Function for TOM1L2 Gene

Molecular function for TOM1L2 Gene

GENATLAS Biochemistry:
v-Myb target gene-like 2,retroviral oncogene,involved in transformation of myelomonoctic cells,in the Smith-Magenis critical region
UniProtKB/Swiss-Prot Function:
Probable role in protein transport. May regulate growth factor-induced mitogenic signaling.
genes like me logo Genes that share phenotypes with TOM1L2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TOM1L2 Gene

Localization for TOM1L2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TOM1L2 Gene COMPARTMENTS Subcellular localization image for TOM1L2 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 3
cytoskeleton 2
endosome 2
golgi apparatus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TOM1L2 Gene

Pathways & Interactions for TOM1L2 Gene

SuperPathways for TOM1L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TOM1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IDA 16479011
genes like me logo Genes that share ontologies with TOM1L2: view

No data available for Pathways by source and SIGNOR curated interactions for TOM1L2 Gene

Drugs & Compounds for TOM1L2 Gene

No Compound Related Data Available

Transcripts for TOM1L2 Gene

Unigene Clusters for TOM1L2 Gene

Target of myb1-like 2 (chicken):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TOM1L2 Gene

No ASD Table

Relevant External Links for TOM1L2 Gene

GeneLoc Exon Structure for
TOM1L2
ECgene alternative splicing isoforms for
TOM1L2

Expression for TOM1L2 Gene

mRNA expression in normal human tissues for TOM1L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TOM1L2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.2), Adrenal (10.2), and Cervix (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TOM1L2 Gene



SOURCE GeneReport for Unigene cluster for TOM1L2 Gene Hs.462379

mRNA Expression by UniProt/SwissProt for TOM1L2 Gene

Q6ZVM7-TM1L2_HUMAN
Tissue specificity: Ubiquitously expressed with higher expression in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with TOM1L2: view

Protein tissue co-expression partners for TOM1L2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TOM1L2 Gene

Orthologs for TOM1L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TOM1L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOM1L2 35
  • 99.67 (n)
  • 99.8 (a)
TOM1L2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TOM1L2 36
  • 90 (a)
OneToOne
TOM1L2 35
  • 86.42 (n)
  • 94.26 (a)
dog
(Canis familiaris)
Mammalia TOM1L2 35
  • 91.72 (n)
  • 97.83 (a)
TOM1L2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tom1l2 36
  • 95 (a)
OneToOne
Tom1l2 16
Tom1l2 35
  • 87.64 (n)
  • 94.87 (a)
oppossum
(Monodelphis domestica)
Mammalia TOM1L2 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TOM1L2 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tom1l2 35
  • 88.52 (n)
  • 94.87 (a)
chicken
(Gallus gallus)
Aves TOM1L2 36
  • 90 (a)
OneToOne
TOM1L2 35
  • 79.68 (n)
  • 92.11 (a)
lizard
(Anolis carolinensis)
Reptilia TOM1L2 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1482 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tom1l2 35
  • 72.87 (n)
  • 82.57 (a)
zebrafish
(Danio rerio)
Actinopterygii TOM1L2 36
  • 72 (a)
OneToOne
LOC100535615 35
  • 70.36 (n)
  • 75.64 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006097 35
  • 53.67 (n)
  • 49.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3529 36
  • 41 (a)
OneToMany
CG3529 35
  • 53.31 (n)
  • 48.97 (a)
worm
(Caenorhabditis elegans)
Secernentea C07A12.7 35
  • 55.18 (n)
  • 52.62 (a)
C07A12.7 36
  • 46 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSE1 36
  • 13 (a)
OneToMany
GGA2 38
Species with no ortholog for TOM1L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TOM1L2 Gene

ENSEMBL:
Gene Tree for TOM1L2 (if available)
TreeFam:
Gene Tree for TOM1L2 (if available)

Paralogs for TOM1L2 Gene

Paralogs for TOM1L2 Gene

(4) SIMAP similar genes for TOM1L2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TOM1L2: view

Variants for TOM1L2 Gene

Sequence variations from dbSNP and Humsavar for TOM1L2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1052299 -- 17,847,105(-) GCTTA(C/T)CAGCA utr-variant-3-prime
rs1889014 -- 17,863,851(-) GTAGT(A/G)TCCAc intron-variant
rs1889015 -- 17,844,512(-) CCATC(C/T)GTCTG utr-variant-3-prime
rs3183702 -- 17,843,975(-) CATTG(C/T)CTGTC utr-variant-3-prime
rs3744113 -- 17,845,331(+) AATGA(C/T)GCCTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TOM1L2 Gene

Variant ID Type Subtype PubMed ID
nsv155 OTHER Inversion 15895083
nsv499114 OTHER Inversion 21111241
nsv907748 CNV Loss 21882294
dgv3072n71 CNV Loss 21882294
nsv833385 CNV Loss 17160897
dgv3073n71 CNV Loss 21882294
nsv522668 CNV Loss 19592680
dgv3074n71 CNV Loss 21882294
dgv3075n71 CNV Loss 21882294
dgv3076n71 CNV Loss 21882294
nsv907766 CNV Loss 21882294
nsv907768 CNV Loss 21882294
nsv510701 CNV Loss 20534489

Variation tolerance for TOM1L2 Gene

Residual Variation Intolerance Score: 17.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TOM1L2 Gene

HapMap Linkage Disequilibrium report
TOM1L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOM1L2 Gene

Disorders for TOM1L2 Gene

Relevant External Links for TOM1L2

Genetic Association Database (GAD)
TOM1L2
Human Genome Epidemiology (HuGE) Navigator
TOM1L2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TOM1L2

No disorders were found for TOM1L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TOM1L2 Gene

Publications for TOM1L2 Gene

  1. Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk. (PMID: 20167577) Reynolds C.A. … Prince J.A. (Hum. Mol. Genet. 2010) 3 48 67
  2. Transcription mapping in a medulloblastoma breakpoint interval and Smith-Magenis syndrome candidate region: identification of 53 transcriptional units and new candidate genes. (PMID: 10036180) Seranski P. … Poustka A. (Genomics 1999) 2 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  5. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. (PMID: 25260751) Charlaftis N. … Gallagher E. (EMBO J. 2014) 3

Products for TOM1L2 Gene

Sources for TOM1L2 Gene

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