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Aliases for TOM1L1 Gene

Aliases for TOM1L1 Gene

  • Target Of Myb1 (Chicken)-Like 1 2 3
  • Src-Activating And Signaling Molecule Protein 3 4
  • Target Of Myb-Like Protein 1 3 4
  • SRCASM 3 4
  • Target Of Myb1 (Chicken) Homolog-Like 1 2
  • Src Activating And Signaling Molecule 3
  • Target Of Myb 1-Like 1 3
  • Target Of Myb1-Like 1 3
  • TOM1-Like Protein 1 3
  • OK/KNS-CL.3 3

External Ids for TOM1L1 Gene

Summaries for TOM1L1 Gene

GeneCards Summary for TOM1L1 Gene

TOM1L1 (Target Of Myb1 (Chicken)-Like 1) is a Protein Coding gene. GO annotations related to this gene include SH3 domain binding and protein kinase activator activity. An important paralog of this gene is STAM2.

UniProtKB/Swiss-Prot for TOM1L1 Gene

  • Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity).

Gene Wiki entry for TOM1L1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOM1L1 Gene

Genomics for TOM1L1 Gene

Genomic Location for TOM1L1 Gene

Start:
54,899,387 bp from pter
End:
54,961,967 bp from pter
Size:
62,581 bases
Orientation:
Plus strand

Genomic View for TOM1L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TOM1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOM1L1 Gene

Regulatory Elements for TOM1L1 Gene

Proteins for TOM1L1 Gene

  • Protein details for TOM1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75674-TM1L1_HUMAN
    Recommended name:
    TOM1-like protein 1
    Protein Accession:
    O75674
    Secondary Accessions:
    • B7Z9E2
    • Q53G06
    • Q8N749

    Protein attributes for TOM1L1 Gene

    Size:
    476 amino acids
    Molecular mass:
    52989 Da
    Quaternary structure:
    • Interacts with FYN, GRB2 and PIK3R1 when phosphorylated. Interacts with LYN.

    Three dimensional structures from OCA and Proteopedia for TOM1L1 Gene

    Alternative splice isoforms for TOM1L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TOM1L1 Gene

Proteomics data for TOM1L1 Gene at MOPED

Post-translational modifications for TOM1L1 Gene

No data available for DME Specific Peptides for TOM1L1 Gene

Domains for TOM1L1 Gene

Protein Domains for TOM1L1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

TM1L1_HUMAN
Domain:
  • Contains 1 GAT domain.:
    • O75674
  • Contains 1 VHS domain.:
    • O75674
Family:
  • Belongs to the TOM1 family.:
    • O75674
genes like me logo Genes that share domains with TOM1L1: view

No data available for Gene Families for TOM1L1 Gene

Function for TOM1L1 Gene

Molecular function for TOM1L1 Gene

UniProtKB/Swiss-Prot Function: Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity).

Gene Ontology (GO) - Molecular Function for TOM1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15611048
GO:0017124 SH3 domain binding IEA --
GO:0019901 protein kinase binding IPI 16479011
GO:0030276 clathrin binding IDA 16412388
GO:0030295 protein kinase activator activity IEA --
genes like me logo Genes that share ontologies with TOM1L1: view

miRNA for TOM1L1 Gene

miRTarBase miRNAs that target TOM1L1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TOM1L1 Gene

Localization for TOM1L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOM1L1 Gene

Golgi apparatus, Golgi stack. Endosome membrane. Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Note=A small proportion is membrane-associated. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TOM1L1 Gene COMPARTMENTS Subcellular localization image for TOM1L1 gene
Compartment Confidence
golgi apparatus 5
cytosol 4
endosome 4
lysosome 4
vacuole 4
nucleus 2

Gene Ontology (GO) - Cellular Components for TOM1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IDA 16412388
GO:0005764 lysosome TAS 10329004
GO:0005768 endosome IDA 15611048
GO:0005794 Golgi apparatus --
genes like me logo Genes that share ontologies with TOM1L1: view

Pathways for TOM1L1 Gene

SuperPathways for TOM1L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TOM1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0007165 signal transduction IDA 16479011
GO:0031954 positive regulation of protein autophosphorylation IDA 16479011
GO:0032147 activation of protein kinase activity IDA 16479011
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway NAS 15611048
genes like me logo Genes that share ontologies with TOM1L1: view

No data available for Pathways by source for TOM1L1 Gene

Compounds for TOM1L1 Gene

(2) Novoseek inferred chemical compound relationships for TOM1L1 Gene

Compound -log(P) Hits PubMed IDs
propanil 89.6 3
tyrosine 48.3 4
genes like me logo Genes that share compounds with TOM1L1: view

Transcripts for TOM1L1 Gene

Unigene Clusters for TOM1L1 Gene

Target of myb1 (chicken)-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TOM1L1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6: -
SP7:
SP8: - - - - - - - - - - - -

Relevant External Links for TOM1L1 Gene

GeneLoc Exon Structure for
TOM1L1
ECgene alternative splicing isoforms for
TOM1L1

Expression for TOM1L1 Gene

mRNA expression in normal human tissues for TOM1L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TOM1L1 Gene

SOURCE GeneReport for Unigene cluster for TOM1L1 Gene Hs.153504

genes like me logo Genes that share expressions with TOM1L1: view

Orthologs for TOM1L1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TOM1L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOM1L1 36
  • 99.58 (n)
  • 99.58 (a)
TOM1L1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TOM1L1 36
  • 88.34 (n)
  • 85.29 (a)
TOM1L1 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TOM1L1 36
  • 88.21 (n)
  • 86.02 (a)
TOM1L1 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tom1l1 36
  • 82.99 (n)
  • 79.19 (a)
Tom1l1 16
Tom1l1 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TOM1L1 37
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TOM1L1 37
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tom1l1 36
  • 83.33 (n)
  • 81.57 (a)
chicken
(Gallus gallus)
Aves TOM1L1 36
  • 63.51 (n)
  • 57.71 (a)
TOM1L1 37
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TOM1L1 37
  • 68 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC52738 36
tropical clawed frog
(Silurana tropicalis)
Amphibia tom1l1 36
  • 57.21 (n)
  • 47.75 (a)
zebrafish
(Danio rerio)
Actinopterygii tom1l2 37
  • 30 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea stam-1 37
  • 14 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSE1 37
  • 11 (a)
OneToMany
Species with no ortholog for TOM1L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TOM1L1 Gene

ENSEMBL:
Gene Tree for TOM1L1 (if available)
TreeFam:
Gene Tree for TOM1L1 (if available)

Paralogs for TOM1L1 Gene

Paralogs for TOM1L1 Gene

genes like me logo Genes that share paralogs with TOM1L1: view

Variants for TOM1L1 Gene

Sequence variations from dbSNP and Humsavar for TOM1L1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1138696 -- 54,938,400(+) gaggc(A/G)gaaga intron-variant
rs1962045 -- 54,918,789(+) tattt(C/T)tcctc intron-variant
rs2332305 -- 54,901,313(+) AGATC(A/T)GAAGA intron-variant
rs2332312 -- 54,919,068(+) TTTAT(A/G)TATAA intron-variant
rs2332313 -- 54,941,464(+) TCTTC(G/T)GTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TOM1L1 Gene

Variant ID Type Subtype PubMed ID
nsv908620 CNV Loss 21882294
nsv457853 CNV Loss 19166990
esv2471400 CNV Deletion 19546169
nsv111920 CNV Loss 16902084

Relevant External Links for TOM1L1 Gene

HapMap Linkage Disequilibrium report
TOM1L1

Disorders for TOM1L1 Gene

(1) Novoseek inferred disease relationships for TOM1L1 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2
genes like me logo Genes that share disorders with TOM1L1: view

No data available for UniProtKB/Swiss-Prot for TOM1L1 Gene

Publications for TOM1L1 Gene

  1. Interactions of TOM1L1 with the multivesicular body sorting machinery. (PMID: 15611048) Puertollano R. (J. Biol. Chem. 2005) 2 3 23
  2. TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM. (PMID: 10329004) Seroussi E. … Dumanski J.P. (Genomics 1999) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Recruitment of clathrin onto endosomes by the Tom1-Tollip complex. (PMID: 16412388) Katoh Y. … Nakayama K. (Biochem. Biophys. Res. Commun. 2006) 3 23
  5. Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes. (PMID: 15047686) Katoh Y. … Nakayama K. (J. Biol. Chem. 2004) 3 23

Products for TOM1L1 Gene

Sources for TOM1L1 Gene

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