Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TOM1L1 Gene

protein-coding   GIFtS: 53
GCID: GC17P052978

Target Of Myb1 (Chicken)-Like 1

(Previous name: target of myb1 (chicken) homolog-like 1)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Target Of Myb1 (Chicken)-Like 11 2     OK/KNS-CL.32
Src-Activating And Signaling Molecule Protein2 3     Src Activating And Signaling Molecule2
Target Of Myb-Like Protein 12 3     Target Of Myb 1-Like 12
SRCASM2 3     Target Of Myb1-Like 12
Target Of Myb1 (Chicken) Homolog-Like 11     TOM1-Like Protein 12

External Ids:    HGNC: 119831   Entrez Gene: 100402   Ensembl: ENSG000001411987   OMIM: 6047015   UniProtKB: O756743   

Export aliases for TOM1L1 gene to outside databases

Previous GC identifers: GC17P052708 GC17P055459 GC17P053320 GC17P053452 GC17P050333 GC17P048336


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for TOM1L1 Gene:
TOM1L1 (target of myb1 (chicken)-like 1) is a protein-coding gene. GO annotations related to this gene include protein kinase activator activity and SH3 domain binding. An important paralog of this gene is STAM2.

UniProtKB/Swiss-Prot: TM1L1_HUMAN, O75674
Function: Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of
various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting
intramolecular SH3-dependent interactions (By similarity)

Gene Wiki entry for TOM1L1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TOM1L1 gene promoter:
         GR   STAT1   AP-4   STAT1alpha   AREB6   FAC1   FOXO1a   c-Myb   GR-alpha   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTOM1L1 promoter sequence
   Search Chromatin IP Primers for TOM1L1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TOM1L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.2   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q23.2

TOM1L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOM1L1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P052978:  view genomic region     (about GC identifiers)

Start:
52,976,748 bp from pter      End:
53,039,328 bp from pter
Size:
62,581 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TM1L1_HUMAN, O75674 (See protein sequence)
Recommended Name: TOM1-like protein 1  
Size: 476 amino acids; 52989 Da
Subunit: Interacts with FYN, GRB2 and PIK3R1 when phosphorylated (By similarity). Interacts with LYN (By
similarity)
1 PDB 3D structure from and Proteopedia for TOM1L1:
3RRU (3D)    
Secondary accessions: Q53G06

Explore the universe of human proteins at neXtProt for TOM1L1: NX_O75674

Explore proteomics data for TOM1L1 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosines by FYN and LYN (By similarity)1
  • Ubiquitination2 at Lys5, Lys148, Lys191
  • Modification sites at PhosphoSitePlus

  • See TOM1L1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005477.2  
    ENSEMBL proteins: 
     ENSP00000458553   ENSP00000460823   ENSP00000459079   ENSP00000408958   ENSP00000343901  
     ENSP00000460721   ENSP00000461876   ENSP00000461284   ENSP00000459003   ENSP00000443099  
     ENSP00000458219   ENSP00000458918   ENSP00000460565   ENSP00000461215   ENSP00000458809  
     ENSP00000461396   ENSP00000460213   ENSP00000467227   ENSP00000441242  

    TOM1L1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TOM1L1
    OriGene Protein Over-expression Lysate for TOM1L1
    OriGene MassSpec for TOM1L1
    OriGene Custom Protein Services for TOM1L1
    GenScript Custom Purified and Recombinant Proteins Services for TOM1L1
    Novus Biologicals TOM1L1 Protein
    Novus Biologicals TOM1L1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TOM1L1

     
    Search eBioscience for Proteins for TOM1L1 

     
    antibodies-online proteins for TOM1L1 (7 products) 

     
    antibodies-online peptides for TOM1L1

    TOM1L1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TOM1L1
    OriGene Custom Antibody Services for TOM1L1
    Novus Biologicals TOM1L1 Antibodies
    Abcam antibodies for TOM1L1
    Cloud-Clone Corp. Antibodies for TOM1L1
    ThermoFisher Antibodies for TOM1L1
    antibodies-online antibodies for TOM1L1 (48 products) 

    TOM1L1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TOM1L1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TOM1L1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TOM1L1
    Cloud-Clone Corp. CLIAs for TOM1L1
    Search eBioscience for ELISAs for TOM1L1 
    antibodies-online kits for TOM1L1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 6):
     IPR002014 VHS
     IPR027428 TOM1L1
     IPR004152 GAT
     IPR018205 VHS_subgr
     IPR008942 ENTH_VHS

    Graphical View of Domain Structure for InterPro Entry O75674

    ProtoNet protein and cluster: O75674

    2 Blocks protein domains:
    IPB002014 VHS
    IPB004152 GAT domain


    UniProtKB/Swiss-Prot: TM1L1_HUMAN, O75674
    Similarity: Belongs to the TOM1 family
    Similarity: Contains 1 GAT domain
    Similarity: Contains 1 VHS domain


    Find genes that share domains with TOM1L1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TM1L1_HUMAN, O75674
    Function: Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of
    various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting
    intramolecular SH3-dependent interactions (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15611048
    GO:0017124SH3 domain binding IEA--
    GO:0019901protein kinase binding IPI16479011
    GO:0030276clathrin binding IDA16412388
    GO:0030295protein kinase activator activity IEA--
         
    Find genes that share ontologies with TOM1L1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TOM1L1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TOM1L1:
    hsa-mir-124-3p (MIRT002599), hsa-mir-92a-3p (MIRT049735)

    Block miRNA regulation of human, mouse, rat TOM1L1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TOM1L1 (see all 24):
    hsa-miR-181c hsa-miR-4272 hsa-miR-301a hsa-miR-944 hsa-miR-340 hsa-miR-519a hsa-miR-633 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidTOM1L1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TOM1L1
    Predesigned siRNA for gene silencing in human, mouse, rat TOM1L1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TOM1L1

    Clone
    Products:
         
    OriGene clones in human, mouse for TOM1L1 (see all 8)
    OriGene ORF clones in mouse, rat for TOM1L1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TOM1L1 (NM_005486)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOM1L1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOM1L1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TOM1L1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TOM1L1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOM1L1

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA4-10924) for TOM1L1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TM1L1_HUMAN, O75674: Golgi apparatus, Golgi stack. Endosome membrane (Potential). Cytoplasm (By similarity).
    Membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=A small proportion is
    membrane-associated (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol4
    endosome4
    lysosome4
    vacuole4
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA16412388
    GO:0005764lysosome TAS10329004
    GO:0005768endosome IDA15611048
    GO:0005795Golgi stack IEA--

    Find genes that share ontologies with TOM1L1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TOM1L1
    Interactions:

        GeneGlobe Interaction Network for TOM1L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TOM1L1 (O756741, 2, 3 ENSP000004089584) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC47Q96A332, 3, ENSP000002257264MINT-65105 I2D: score=5 STRING: ENSP00000225726
    AMFRQ9UKV52, 3, ENSP000002906494MINT-8247696 I2D: score=2 STRING: ENSP00000290649
    TSG101Q998162, 3, ENSP000002519684MINT-58564 I2D: score=2 STRING: ENSP00000251968
    VCPP550722, 3, ENSP000003517774MINT-8276971 I2D: score=2 STRING: ENSP00000351777
    VAV2P527351, 3, ENSP000003609164EBI-712991,EBI-297549 I2D: score=1 STRING: ENSP00000360916
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0007165signal transduction IDA16479011
    GO:0031954positive regulation of protein autophosphorylation IDA16479011
    GO:0032147activation of protein kinase activity IDA16479011
    GO:0043162ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway NAS15611048

    Find genes that share ontologies with TOM1L1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TOM1L1 (TM1L1)

    2 Novoseek inferred chemical compound relationships for TOM1L1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    propanil 89.6 3 16412388 (1), 15047686 (1), 15611048 (1)
    tyrosine 48.3 6 15579470 (2), 15611048 (2)



    Find genes that share compounds with TOM1L1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TOM1L1 gene: 
    NM_005486.2  

    Unigene Cluster for TOM1L1:

    Target of myb1 (chicken)-like 1
    Hs.153504  [show with all ESTs]
    Unigene Representative Sequence: NM_005486
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000570371(uc002iuc.3) ENST00000574744 ENST00000575882(uc002iud.2 uc010dca.1 uc010wnb.1 uc010wnc.1 uc010dbz.2 uc010wnd.1)
    ENST00000570965 ENST00000445275 ENST00000348161 ENST00000572405(uc002iub.3)
    ENST00000576932(uc010dcb.1) ENST00000572158 ENST00000572298 ENST00000536554
    ENST00000571319 ENST00000575333 ENST00000572360 ENST00000570499 ENST00000572576
    ENST00000573607 ENST00000575909
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TOM1L1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TOM1L1 (see all 24):
    hsa-miR-181c hsa-miR-4272 hsa-miR-301a hsa-miR-944 hsa-miR-340 hsa-miR-519a hsa-miR-633 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidTOM1L1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TOM1L1
    Predesigned siRNA for gene silencing in human, mouse, rat TOM1L1
    Clone
    Products:
         
    OriGene clones in human, mouse for TOM1L1 (see all 8)
    OriGene ORF clones in mouse, rat for TOM1L1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TOM1L1 (NM_005486)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOM1L1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOM1L1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TOM1L1
    OriGene qSTAR qPCR primer pairs in human, mouse for TOM1L1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TOM1L1
      QuantiTect SYBR Green Assays in human, mouse, rat TOM1L1
      QuantiFast Probe-based Assays in human, mouse, rat TOM1L1
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA4-10924) for TOM1L1 

    Additional mRNA sequence: 

    AB065085.1 AJ010071.1 AK001893.1 AK223125.1 AK300823.1 AK303912.1 AK303913.1 AK309164.1 
    AK315039.1 AK315907.1 BC029396.1 

    19 DOTS entries:

    DT.92452799  DT.100826978  DT.100826973  DT.100708137  DT.120913738  DT.92452815  DT.120913732  DT.86853933 
    DT.99994894  DT.120913725  DT.120913730  DT.120913748  DT.40283917  DT.92452810  DT.97802220  DT.120913761 
    DT.97781384  DT.97802833  DT.40264916 

    Selected AceView cDNA sequences (see all 215):

    AW780165 CB241257 BP377283 AA889971 BU623140 BQ009892 BM842867 BM684011 
    CR593166 AW016358 BM468636 AL599913 BQ225192 AA740164 BI760691 AI123490 
    BM932013 AI613215 BM788711 AA843483 AB065085 CB242196 AW105672 N22579 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TOM1L1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                -     -                                                                                             
    SP2:                                -     -                                                                                             
    SP3:                                -     -     -                                                                                       
    SP4:                                -     -     -     -                                                                                 
    SP5:                                -     -                                   -                                                         


    ECgene alternative splicing isoforms for TOM1L1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TOM1L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TOM1L1 Expression
    About this image


    TOM1L1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Thyroid (Endocrine System)
     
     Liver (Hepatobiliary System)
     
     Kidney (Urinary System)
     
     Stomach (Gastrointestinal Tract)
    TOM1L1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TOM1L1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.153504
        Custom PCR Arrays for TOM1L1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TOM1L1
    OriGene qSTAR qPCR primer pairs in human, mouse for TOM1L1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TOM1L1
    QuantiTect SYBR Green Assays in human, mouse, rat TOM1L1
    QuantiFast Probe-based Assays in human, mouse, rat TOM1L1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOM1L1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TOM1L1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tom1l11 , 5 target of myb1-like 1 (chicken)1, 5 82.99(n)1
    79.19(a)1
      11 (55.47 cM)5
    719431  NM_028011.21  NP_082287.11 
     906434655 
    chicken
    (Gallus gallus)
    Aves TOM1L11 target of myb1-like 1 63.51(n)
    57.71(a)
      417391  XM_415646.4  XP_415646.3 
    lizard
    (Anolis carolinensis)
    Reptilia TOM1L16
    target of myb1 (chicken)-like 1
    68(a)
    1 ↔ 1
    GL343242.1(1874870-1913470)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC527382 similar to Src activating and signaling molecule 73.19(n)    BC042344.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tom1l26
    target of myb1-like 2 (chicken)
    30(a)
    many ↔ many
    12(19402636-19434553) ENSDARG00000009217
    worm
    (Caenorhabditis elegans)
    Secernentea stam-16
    Protein STAM-1, isoform a
    14(a)
    many ↔ many
    I(5902095-5904689) WBGene00004109
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HSE16
    Subunit of the endosomal Vps27p-Hse1p complex requ...
    11(a)
    1 → many
    VIII(102612-103970) YHL002W


    ENSEMBL Gene Tree for TOM1L1 (if available)
    TreeFam Gene Tree for TOM1L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TOM1L1 gene
    STAM22  TOM1L22  TOM12  STAM2  
    5 SIMAP similar genes for TOM1L1 using alignment to 17 protein entries:     TM1L1_HUMAN (see all proteins):
    GGA2    TOM1    TOM1L2    GGA1    GGA3

    Find genes that share paralogs with TOM1L1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TOM1L1 (see all 1022)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1504794141,2
    C--52976066(+) GAAATC/TGTGGT 1 -- us2k10--------
    rs1830611871,2
    --52976070(+) TTGTGA/GTAAGA 1 -- us2k10--------
    rs1880963911,2
    --52976091(+) GGTGTC/TATTTT 1 -- us2k10--------
    rs1929084001,2
    --52976270(+) CAACAC/TCCTGG 1 -- us2k10--------
    rs733195471,2
    C,F--52976281(+) AGGGCA/GCAGGG 1 -- us2k12Minor allele frequency- G:0.10WA 120
    rs80671391,2
    C,F,H--52976319(+) CTGAGA/CTAGAA 1 -- us2k117Minor allele frequency- C:0.27NS EA NA WA CSA 1346
    rs733195481,2
    C,F--52976411(+) TTCTCG/AGTGCC 1 -- us2k12Minor allele frequency- A:0.10WA 120
    rs1383105601,2
    --52976435(+) GTAAGA/GAAATC 1 -- us2k10--------
    rs341373671,2
    C--52976459(+) AAAAAA/-GAAGA 1 -- us2k12Minor allele frequency- -:0.25NA CSA 4
    rs728409661,2
    C--52976459(+) AAAAAA/CAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TOM1L1 (52976748 - 53039328 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TOM1L1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2471400CNV Deletion19546169
    nsv457853CNV Loss19166990
    nsv908620CNV Loss21882294
    nsv111920CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TOM1L1
    DNA2.0 Custom Variant and Variant Library Synthesis for TOM1L1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604701    OMIM disorders: --


    Find genes that share disorders with TOM1L1           About GenesLikeMe

    1 Novoseek inferred disease relationship for TOM1L1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 15579470 (1), 15611048 (1)


    Export disorders for TOM1L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TOM1L1 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with TOM1L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM. (PubMed id 10329004)1, 2, 3 Seroussi E....Dumanski J.P. (Genomics 1999)
    2. Interactions of TOM1L1 with the multivesicular body sorting machinery. (PubMed id 15611048)1, 3, 9 Puertollano R. (J. Biol. Chem. 2005)
    3. TOM1L1 is a Lyn substrate involved in FcepsilonRI signaling in mast cells. (PubMed id 17977829)1, 3 Zhang J.... Siraganian R.P. (J. Biol. Chem. 2007)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Srcasm modulates EGF and Src-kinase signaling in keratinocytes. (PubMed id 15579470)1, 9 Li W....Seykora J. (J. Biol. Chem. 2005)
    6. Decreased Srcasm expression in hyperproliferative cutaneous lesions. (PubMed id 19220627)1, 9 Meulener M.C....Seykora J.T. (J. Cutan. Pathol. 2009)
    7. Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes. (PubMed id 15047686)1, 9 Katoh Y....Nakayama K. (J. Biol. Chem. 2004)
    8. Recruitment of clathrin onto endosomes by the Tom1-Tollip complex. (PubMed id 16412388)1, 9 Katoh Y.... Nakayama K. (Biochem. Biophys. Res. Commun. 2006)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Analysis of SRC oncogenic signaling in colorectal cancer by stable isotope labeling with heavy amino acids in mouse xenografts. (PubMed id 23023324)1 Sirvent A....Roche S. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10040 HGNC: 11983 AceView: TOM1L1 Ensembl:ENSG00000141198 euGenes: HUgn10040
    ECgene: TOM1L1 H-InvDB: TOM1L1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TOM1L1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TOM1L1 gene:
    Search GeneIP for patents involving TOM1L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TOM1L1   OriGene RNAi products in human, mouse, rat for TOM1L1  
     OriGene qPCR primer pairs and template standards for TOM1L1   OriGene Protein Over-expression Lysate for TOM1L1  
     OriGene MassSpec for TOM1L1   OriGene clones in human, mouse for TOM1L1  
     OriGene qSTAR qPCR primer pairs in human, mouse for TOM1L1   OriGene Purified Protein for TOM1L1  
     OriGene ORF clones in mouse, rat for TOM1L1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TOM1L1   OriGene Custom Protein Services for TOM1L1  

     
     
     Block miRNA regulation of human, mouse, rat TOM1L1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TOM1L1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TOM1L1 Predesigned siRNA for gene silencing in human, mouse, rat TOM1L1
     QuantiFast Probe-based Assays in human, mouse, rat TOM1L1 QuantiTect SYBR Green Assays in human, mouse, rat TOM1L1
     Custom PCR Arrays for TOM1L1 Search Chromatin IP Primers for TOM1L1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TOM1L1  GeneGlobe Interaction Network for TOM1L1
     Regulatory tfbs in TOM1L1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TOM1L1 GenScript cDNA clones with any tag delivered in your preferred vector for TOM1L1
     GenScript Custom Assay Services for TOM1L1 GenScript Custom overexpressing Cell Line Services for TOM1L1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TOM1L1 (TM1L1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TOM1L1 antibodies
     TOM1L1 proteins
     TOM1L1 lysates
     Antibodies for TOM1L1
     See all of Abcam's Antibodies, Kits and Proteins for TOM1L1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TOM1L1
     Antibodies for TOM1L1
     ELISAs for TOM1L1
     CLIAs for TOM1L1



     Browse ESI BIO Cell Lines and PureStem Progenitors for TOM1L1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOM1L1
     SwitchGear 3'UTR luciferase reporter plasmids for TOM1L1
     SwitchGear Promoter luciferase reporter plasmids for TOM1L1
     ThermoFisher Antibodies for TOM1L1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOM1L1
     Browse compounds at ApexBio
     Search Addgene for plasmids for TOM1L1
      Search eBioscience for proteins for TOM1L1
      Search eBioscience for elisas for TOM1L1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for TOM1L1
     antibodies-online antibodies for TOM1L1 (48 products)
     antibodies-online kits for TOM1L1 (4 products)
     antibodies-online peptides for TOM1L1
     antibodies-online proteins for TOM1L1 (7 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TOM1L1 gene at Home site.
    Version: 3.12.248 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4