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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TOM1L1 Gene

protein-coding   GIFtS: 52
GCID: GC17P052978

target of myb1 (chicken)-like 1

(Previous name: target of myb1 (chicken) homolog-like 1 )
 Explore 6 diseases affiliated with
TOM1L1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TOM1L1    

Aliases
for TOM1L1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Target Of Myb1 (Chicken)-Like 11 2     OK/KNS-CL.32
SRCASM1 2 3     Src Activating And Signaling Molecule2
Src-Activating And Signaling Molecule Protein2 3     Target Of Myb 1-Like 12
Target Of Myb-Like Protein 12 3     Target Of Myb1-Like 12
Target Of Myb1 (Chicken) Homolog-Like 11     TOM1-Like Protein 12

External Ids:    HGNC: 119831   Entrez Gene: 100402   Ensembl: ENSG000001411987   OMIM: 6047015   UniProtKB: O756743   

Export aliases for TOM1L1 gene to outside databases

Previous GC identifers: GC17P052708 GC17P055459 GC17P053320 GC17P053452 GC17P050333 GC17P048336


Summaries
for TOM1L1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TM1L1_HUMAN, O75674
Function: Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various
signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular
SH3-dependent interactions (By similarity)

Gene Wiki entry for TOM1L1


Genomic Views
for TOM1L1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TOM1L1 gene promoter:
         GR   STAT1   AP-4   STAT1alpha   AREB6   FAC1   FOXO1a   c-Myb   GR-alpha   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TOM1L1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TOM1L1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOM1L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.2   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q23.2

TOM1L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOM1L1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P052978:  view genomic region     (about GC identifiers)

Start:
 52,976,748 bp from pter      End:
 53,039,328 bp from pter
Size:
 62,581 bases      Orientation:
 plus strand

Proteins
for TOM1L1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TM1L1_HUMAN, O75674 (See protein sequence)
Recommended Name: TOM1-like protein 1  
Size: 476 amino acids; 52989 Da
Subunit: Interacts with FYN, GRB2 and PIK3R1 when phosphorylated (By similarity). Interacts with LYN (By similarity)
Subcellular location: Golgi apparatus, Golgi stack. Endosome membrane (Potential). Cytoplasm (By similarity). Membrane;
Peripheral membrane protein; Cytoplasmic side (By similarity). Note=A small proportion is membrane-associated (By
similarity)
1 PDB 3D structure from and Proteopedia for TOM1L1:
3RRU (3D)    
Secondary accessions: Q53G06

Explore the universe of human proteins at neXtProt for TOM1L1: NX_O75674

Post-translational modifications:

  • Phosphorylated on tyrosines by FYN and LYN (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75674

    • TOM1L1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005477.2  
    ENSEMBL proteins: 
     ENSP00000458553   ENSP00000460823   ENSP00000459079   ENSP00000408958   ENSP00000343901  
     ENSP00000460721   ENSP00000461876   ENSP00000461284   ENSP00000459003   ENSP00000443099  
     ENSP00000458219   ENSP00000458918   ENSP00000460565   ENSP00000461215   ENSP00000458809  
     ENSP00000461396   ENSP00000460213   ENSP00000467227   ENSP00000441242  

    Human Recombinant Protein Products: 
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    Novus Biologicals TOM1L1 Protein
    Novus Biologicals TOM1L1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TOM1L1

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005764lysosome TAS10329004
    GO:0005768endosome IDA15611048
    GO:0005795Golgi stack IEA--
    GO:0005829cytosol IDA15611048


    TOM1L1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for TOM1L1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TOM1L1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR002014 VHS
     IPR004152 GAT
     IPR018205 VHS_subgr
     IPR008942 ENTH_VHS
     IPR014645 TOM1

    Graphical View of Domain Structure for InterPro Entry O75674

    ProtoNet protein and cluster: O75674

    2 Blocks protein families:
    IPB002014 VHS
    IPB004152 GAT domain


    UniProtKB/Swiss-Prot: TM1L1_HUMAN, O75674
    Similarity: Belongs to the TOM1 family
    Similarity: Contains 1 GAT domain
    Similarity: Contains 1 VHS domain


    Function
    for TOM1L1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TM1L1_HUMAN, O75674
    Function: Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various
    signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular
    SH3-dependent interactions (By similarity)

    miRNA
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    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate TOM1L1 (see all 24):
    hsa-miR-181c hsa-miR-4272 hsa-miR-301a hsa-miR-944 hsa-miR-340 hsa-miR-519a hsa-miR-633 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmid: TOM1L1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: TOM1L1
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0017124SH3 domain binding IEA--
    GO:0030295protein kinase activator activity IEA--
    GO:0043130ubiquitin binding TAS15611048


    TOM1L1 for ontologies           About GeneDecksing



    Pathways & Interactions
    for TOM1L1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TOM1L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/42 Interacting proteins for TOM1L1 (O756741, 2, 3 ENSP000004089584) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC47Q96A332, 3, ENSP000002257264MINT-65105 I2D: score=5 STRING: ENSP00000225726
    AMFRQ9UKV52, 3, ENSP000002906494MINT-8247696 I2D: score=2 STRING: ENSP00000290649
    TSG101Q998162, 3, ENSP000002519684MINT-58564 I2D: score=2 STRING: ENSP00000251968
    VCPP550722, 3, ENSP000003517774MINT-8276971 I2D: score=2 STRING: ENSP00000351777
    VAV2P527351, 3, ENSP000003609164EBI-712991,EBI-297549 I2D: score=1 STRING: ENSP00000360916
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation ----
    GO:0006886intracellular protein transport IEA--
    GO:0043162ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway NAS15611048


    TOM1L1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TOM1L1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TOM1L1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TOM1L1
    2 Novoseek chemical compound relationships for TOM1L1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    propanil 89.6 3 16412388 (1), 15047686 (1), 15611048 (1)
    tyrosine 48.3 6 15579470 (2), 15611048 (2)

    Search CenterWatch for drugs/clinical trials and news about TOM1L1 / TM1L1 

    Transcripts
    for TOM1L1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TOM1L1 gene: 
    NM_005486.2  

    Unigene Cluster for TOM1L1:

    Target of myb1 (chicken)-like 1
    Hs.153504  [show with all ESTs]
    Unigene Representative Sequence: NM_005486
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000570371(uc002iuc.3) ENST00000574744 ENST00000575882(uc002iud.2 uc010dca.1 uc010wnb.1 uc010wnc.1 uc010dbz.2 uc010wnd.1)
    ENST00000570965 ENST00000445275 ENST00000348161 ENST00000572405(uc002iub.3)
    ENST00000576932(uc010dcb.1) ENST00000572158 ENST00000572298 ENST00000536554
    ENST00000571319 ENST00000575333 ENST00000572360 ENST00000570499 ENST00000572576
    ENST00000573607 ENST00000575909

    miRNA
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    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate TOM1L1 (see all 24):
    hsa-miR-181c hsa-miR-4272 hsa-miR-301a hsa-miR-944 hsa-miR-340 hsa-miR-519a hsa-miR-633 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmid: TOM1L1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: TOM1L1
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOM1L1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOM1L1

    Additional cDNA sequence: 

    AB065085.1 AJ010071.1 AK001893.1 AK223125.1 AK300823.1 AK303912.1 AK303913.1 AK309164.1 
    AK315039.1 AK315907.1 BC029396.1 

    19 DOTS entries:

    DT.92452799  DT.100826978  DT.100826973  DT.100708137  DT.120913738  DT.92452815  DT.120913732  DT.86853933 
    DT.99994894  DT.120913725  DT.120913730  DT.120913748  DT.40283917  DT.92452810  DT.97802220  DT.120913761 
    DT.97781384  DT.97802833  DT.40264916 

    24/215 AceView cDNA sequences (see all 215):

    AI123490 BM788711 AW016358 AI366889 R79692 BC029396 AI634439 BQ051429 
    AW105672 BQ225192 AI025620 BM932013 AB065085 AA457644 AA740164 BI760691 
    AI539557 BU623140 AL134445 BM769670 CR593166 AA457643 AA312488 N22579 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TOM1L1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                -     -                                                                                             
    SP2:                                -     -                                                                                             
    SP3:                                -     -     -                                                                                       
    SP4:                                -     -     -     -                                                                                 
    SP5:                                -     -                                   -                                                         


    ECgene alternative splicing isoforms for TOM1L1

    Expression
    for TOM1L1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TOM1L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See TOM1L1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TOM1L1

    SOURCE GeneReport for Unigene cluster: Hs.153504
        SABiosciences Custom PCR Arrays for TOM1L1
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    In Situ
    Assay Products:     
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    Orthologs
    for TOM1L1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TOM1L1 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TOM1L11 target of myb1 (chicken)-like 1 63.51(n)
    57.71(a)    		   417391  XM_415646.3  XP_415646.3 
    lizard
    (Anolis carolinensis)    		 Reptilia TOM1L16
    		 --
    		 68(a)
    		 1 ↔ 1
    		 GL343242.1(1875259-1913470)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC527382 similar to Src activating and signaling molecule 73.19(n)    BC042344.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G087906
    AT1G769706
    (see all 9)    		 Target of Myb protein 1
    (see all 9)    		 9(a)
    15(a)
    (see all 9)    		 many ↔ many
    many ↔ many
    (see all 9)    		 3(2667881-2671001)
    1(28922666-28925404)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 10)    		 VHS and GAT domain containing protein, expressed
    (see all 10)    		 14(a)
    14(a)
    (see all 10)    		 many ↔ many
    many ↔ many
    (see all 10)    		 10(22980611-22983543)
    2(28667133-28671003)


    ENSEMBL Gene Tree for TOM1L1 (if available)
    TreeFam Gene Tree for TOM1L1 (if available) 

    Paralogs
    for TOM1L1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TOM1L1 gene
    GGA22  TOM1L22  TOM12  GGA12  GGA32  
    5 SIMAP similar genes for TOM1L1 using alignment to 17 protein entries:     TM1L1_HUMAN (see all proteins):
    GGA2    TOM1    TOM1L2    GGA1    GGA3

    TOM1L1 for paralogs           About GeneDecksing



    Genomic Variants
    for TOM1L1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/847 NCBI SNPs in TOM1L1 are shown (see all 847)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs620735611,2
    		--48350678(+) AAAAAG/AGGGCA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1504794141,2
    		--52976066(+) GAAATC/TGTGGT 1 -- us2k10--------
    rs1830611871,2
    		--52976070(+) TTGTGA/GTAAGA 1 -- us2k10--------
    rs1880963911,2
    		--52976091(+) GGTGTC/TATTTT 1 -- us2k10--------
    rs1929084001,2
    		--52976270(+) CAACAC/TCCTGG 1 -- us2k10--------
    rs733195471,2
    		C,--52976281(+) AGGGCA/GCAGGG 1 -- us2k12Minor allele frequency- G:0.10WA 120
    rs80671391,2
    		C,F,H,--52976319(+) CTGAGA/CTAGAA 1 -- us2k117Minor allele frequency- C:0.27NS EA NA WA CSA 1346
    rs733195481,2
    		C,--52976411(+) TTCTCG/AGTGCC 1 -- us2k12Minor allele frequency- A:0.10WA 120
    rs1383105601,2
    		--52976435(+) GTAAGA/GAAATC 1 -- us2k10--------
    rs728409661,2
    		C,--52976459(+) AAAAAA/CAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TOM1L1 (52976748 - 53039328 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for TOM1L1
         2 CNVs: 102484 5869
         1 Indel: 60237

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    Disorders / Diseases
    for TOM1L1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TOM1L1 for disorders           About GeneDecksing

    OMIM gene information: 604701    OMIM disorders: --

    6 diseases for TOM1L1:    About MalaCards
    psoriasis    pancreatic cancer    colorectal cancer    pancreatitis
    esophagitis    carcinoma

    1 Novoseek disease relationship for TOM1L1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 15579470 (1), 15611048 (1)


    Export disorders for TOM1L1 gene to outside databases

    Publications
    for TOM1L1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TOM1L1 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with TOM1L1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM. (PubMed id 10329004)1, 2, 3 Seroussi E....Dumanski J.P. (1999)
    2. Interactions of TOM1L1 with the multivesicular body sorting machinery. (PubMed id 15611048)1, 3, 9 Puertollano R. (2005)
    3. TOM1L1 is a Lyn substrate involved in FcepsilonRI sig naling in mast cells. (PubMed id 17977829)1, 3 Zhang J....Siraganian R.P. (2007)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Srcasm modulates EGF and Src-kinase signaling in keratinocytes. (PubMed id 15579470)1, 9 Li W....Seykora J. (2005)
    6. Decreased Srcasm expression in hyperproliferative cutaneous lesions. (PubMed id 19220627)1, 9 Meulener M.C....Seykora J.T. (2009)
    7. Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes. (PubMed id 15047686)1, 9 Katoh Y....Nakayama K. (2004)
    8. Recruitment of clathrin onto endosomes by the Tom1-Tollip complex. (PubMed id 16412388)1, 9 Katoh Y.... Nakayama K. (2006)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    External Searches for TOM1L1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    OMIM
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    Genome Databases showing TOM1L1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10040 HGNC: 11983 AceView: TOM1L1 Ensembl:ENSG00000141198 euGenes: HUgn10040
    ECgene: TOM1L1 H-InvDB: TOM1L1

    Other Databases showing TOM1L1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TOM1L1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TOM1L1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TOM1L1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TOM1L1 gene:
    Search GeneIP for patents involving TOM1L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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