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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TOM1 Gene

protein-coding   GIFtS: 62
GCID: GC22P035695

Target Of Myb1 (Chicken)

(Previous name: target of myb1 (chicken) homolog)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Target Of Myb1 (Chicken)1 2
Target Of Myb1 (Chicken) Homolog1
Target Of Myb 12
Target Of Myb Protein 12

External Ids:    HGNC: 119821   Entrez Gene: 100432   Ensembl: ENSG000001002847   OMIM: 6047005   UniProtKB: O607843   
ORGUL members:         
NONCODE14:n406661      

Export aliases for TOM1 gene to outside databases

Previous GC identifers: GC22P032391 GC22P034020 GC22P018656


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TOM1 Gene:
This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in
common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by
its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have
been found for this gene. (provided by RefSeq, Oct 2008)

GeneCards Summary for TOM1 Gene: 
TOM1 (target of myb1 (chicken)) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with TOM1 include chronic wasting disease, and adult acute lymphocytic leukemia. GO annotations related to this gene include protein binding. An important paralog of this gene is STAM2.

UniProtKB/Swiss-Prot: TOM1_HUMAN, O60784
Function: May be involved in intracellular trafficking. Probable association with membranes

Gene Wiki entry for TOM1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TOM1 gene promoter:
         Sox5   AP-1   ATF-2   c-Jun   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTOM1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TOM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q13.1

TOM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOM1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P035695:  view genomic region     (about GC identifiers)

Start:
35,695,268 bp from pter      End:
35,743,987 bp from pter
Size:
48,720 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TOM1_HUMAN, O60784 (See protein sequence)
Recommended Name: Target of Myb protein 1  
Size: 492 amino acids; 53818 Da
Subunit: Interacts with ZFYVE16; interaction is required to target it to endosomes
Subcellular location: Cytoplasm (Probable). Membrane; Peripheral membrane protein (Probable)
2 PDB 3D structures from and Proteopedia for TOM1:
1ELK (3D)        1WRD (3D)    
Secondary accessions: B4DEL9 B4DNA1 Q5TIJ6 Q86X74
Alternative splicing: 4 isoforms:  O60784-1   O60784-2   O60784-3   O60784-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TOM1: NX_O60784

Explore proteomics data for TOM1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60784

  • TOM1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TOM1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001129201.1  NP_001129202.1  NP_001129204.1  NP_005479.1  

    ENSEMBL proteins: 
     ENSP00000393714   ENSP00000394466   ENSP00000385906   ENSP00000394944   ENSP00000397492  
     ENSP00000379085   ENSP00000390429   ENSP00000389789   ENSP00000413697   ENSP00000394924  
     ENSP00000402556   ENSP00000398876   ENSP00000371465  

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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TOM1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005769early endosome IDA14613930
    GO:0005829cytosol IDA14613930
    GO:0016020membrane IDA14613930

    TOM1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR002014 VHS
     IPR004152 GAT
     IPR018205 VHS_subgr
     IPR008942 ENTH_VHS
     IPR014645 TOM1

    Graphical View of Domain Structure for InterPro Entry O60784

    ProtoNet protein and cluster: O60784

    2 Blocks protein domains:
    IPB002014 VHS
    IPB004152 GAT domain


    UniProtKB/Swiss-Prot: TOM1_HUMAN, O60784
    Similarity: Belongs to the TOM1 family
    Similarity: Contains 1 GAT domain
    Similarity: Contains 1 VHS domain


    TOM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TOM1_HUMAN, O60784
    Function: May be involved in intracellular trafficking. Probable association with membranes

         Genatlas biochemistry entry for TOM1:
    target of mybl (chicken ortholog),ubiquitous with highest expression in skeletal
    muscle,placenta,heart,liver,involved in the control of vesicular trafficking to lysosome (suppression of cell
    growth)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14613930
         
    TOM1 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for TOM1:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella-containin 

    Animal Models:
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    miRNA
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    hsa-mir-126 (MIRT000967)

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    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate TOM1 (see all 16):
    hsa-miR-126 hsa-miR-34c-5p hsa-miR-449b hsa-miR-449a hsa-miR-650 hsa-miR-124 hsa-miR-34a hsa-miR-2116*
    SwitchGear 3'UTR luciferase reporter plasmidTOM1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOM1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TOM1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1C-MYB transcription factor network
    C-MYB transcription factor network


    1 BioSystems Pathway for TOM1
        C-MYB transcription factor network



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TOM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/22 Interacting proteins for TOM1 (O607841, 2, 3 ENSP000004136974) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TOM1L1O756742, 3, ENSP000004089584MINT-7980618 MINT-7980599 I2D: score=1 STRING: ENSP00000408958
    ZFYVE16Q7Z3T81, 3, ENSP000003371594EBI-74634,EBI-298055 I2D: score=5 STRING: ENSP00000337159
    ZNF512BQ96KM62, 3MINT-60835 I2D: score=2 
    HGSO149642, 3, ENSP000003312014MINT-58566 I2D: score=1 STRING: ENSP00000331201
    IL1R1P147783, ENSP000002339464I2D: score=1 STRING: ENSP00000233946
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006897endocytosis NAS10329004
    GO:0015031protein transport NAS14613930
    GO:0016197endosomal transport TAS10329004

    TOM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TOM1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TOM1

    2 Novoseek inferred chemical compound relationships for TOM1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    propanil 90.2 4 10329004 (2), 14563850 (1), 14613930 (1)
    tyrosine 8.87 1 10329004 (1)

    Search CenterWatch for drugs/clinical trials and news about TOM1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TOM1 gene (4 alternative transcripts): 
    NM_001135729.1  NM_001135730.1  NM_001135732.1  NM_005488.2  

    Unigene Cluster for TOM1:

    Target of myb1 (chicken)
    Hs.474705  [show with all ESTs]
    Unigene Representative Sequence: AK097926
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000456128 ENST00000449058 ENST00000404284(uc003ano.3) ENST00000465529
    ENST00000487670 ENST00000439512 ENST00000424387 ENST00000395736 ENST00000449508
    ENST00000443206 ENST00000497448 ENST00000491987 ENST00000492723 ENST00000411850(uc011amj.2 uc003anp.3 uc003ann.3 uc011amk.2)
    ENST00000425375(uc011aml.2) ENST00000436462 ENST00000447733(uc011ami.2)
    ENST00000382034
    miRNA
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    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate TOM1 (see all 16):
    hsa-miR-126 hsa-miR-34c-5p hsa-miR-449b hsa-miR-449a hsa-miR-650 hsa-miR-124 hsa-miR-34a hsa-miR-2116*
    SwitchGear 3'UTR luciferase reporter plasmidTOM1 3' UTR sequence
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    Additional mRNA sequence: 

    AF040251.1 AJ006973.1 AK026576.1 AK090723.1 AK091958.1 AK097066.1 AK097926.1 AK293694.1 
    AK295918.1 AK296670.1 AK297827.1 AK314522.1 AY358980.1 BC040006.1 BC046151.1 CR456595.1 
    NR_024194.1 NR_024195.1 

    24/33 DOTS entries (see all 33):

    DT.117662  DT.99937389  DT.120669866  DT.100879921  DT.100879933  DT.100879929  DT.95242925  DT.100879939 
    DT.120669875  DT.120669870  DT.100028876  DT.100879925  DT.100879940  DT.100879920  DT.100879930  DT.92431542 
    DT.100879937  DT.100879938  DT.120669854  DT.120669896  DT.91979131  DT.100801815  DT.100879934  DT.100879936 

    24/354 AceView cDNA sequences (see all 354):

    AJ006973 BX331643 BM912395 BM547582 CB141386 AK097066 AL041625 BX326562 
    BU069230 BU553411 BX368813 CR617054 CA420680 BX430436 F13133 BC040006 
    BF515547 CD672145 BC046151 CR605275 CA773956 CR611082 NM_005488 H55094 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TOM1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b
    SP1:                          -                 -           -     -                                                           -                           
    SP2:                          -     -           -           -     -                             -                             -                           
    SP3:                          -     -           -           -     -                             -                             -                           
    SP4:                          -     -           -                                                                                                         
    SP5:                          -     -                                                                                                                     


    ECgene alternative splicing isoforms for TOM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TOM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTTGGCTG
    TOM1 Expression
    About this image


    See TOM1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TOM1

    SOURCE GeneReport for Unigene cluster: Hs.474705

    UniProtKB/Swiss-Prot: TOM1_HUMAN, O60784
    Tissue specificity: Widely expressed. Highly expressed in skeletal muscle, heart, placenta and liver

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TOM1 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tom11 , 5 target of myb1 homolog (chicken)1, 5 85.91(n)1
    89.23(a)1
      8 (35.57 cM)5
    219681  NM_001136259.11  NP_001129731.11 
     750336865 
    chicken
    (Gallus gallus)
    Aves TOM11 target of myb1 (chicken) 75.7(n)
    78.44(a)
      396049  NM_205144.1  NP_990475.1 
    lizard
    (Anolis carolinensis)
    Reptilia TOM16
    target of myb1 (chicken)
    72(a)
    1 ↔ 1
    5(21440266-21469371)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.150402 Transcribed sequence with weak similarity to protein more 76.53(n)    CF783101.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC056566.12   -- 78.82(n)    BC056566.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG35293   -- 41(a)   67B5   --
    worm
    (Caenorhabditis elegans)
    Secernentea C07A12.7b3
    C07A12.71
    Protein C07A12.71 48(a)
    (best of 2)3
    54.9(n)1
    50.74(a)1
      X(4553182-4556331)3
    1807231  NM_076376.31  NP_508777.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HSE16
    Subunit of the endosomal Vps27p-Hse1p complex requ...
    12(a)
    1 → many
    VIII(102612-103970)


    ENSEMBL Gene Tree for TOM1 (if available)
    TreeFam Gene Tree for TOM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TOM1 gene
    STAM22  TOM1L22  TOM1L12  STAM2  
    6 SIMAP similar genes for TOM1 using alignment to 10 protein entries:     TOM1_HUMAN (see all proteins):
    TOM1L2    TOM1L1    GGA3    GGA2    HGS    GGA1

    TOM1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1177 SNPs in TOM1 are shown (see all 1177)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1379706681,2
    --18654374(+) GTCCCA/CCCTAC 1 -- us2k10--------
    rs1387341,2
    C--18659433(+) TTTTT-/T/TTT 
            
    GAGAC
    6 -- int1 trp31NA 2
    rs769514101,2
    C,F--35693273(+) AAGAGG/TCTGAA 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1438589751,2
    --35693340(+) CTGTAA/CGCCAG 1 -- us2k10--------
    rs671259421,2
    C--35693376(+) TTTAAAAAT/-  
            
    AAATA
    1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1486163151,2
    --35693417(+) TTTCAA/GTAGCT 1 -- us2k10--------
    rs117052241,2
    C,H--35693507(+) gcagtA/Ggtgca 1 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs1880629851,2
    --35693535(+) GCTCCA/GCCTAC 1 -- us2k10--------
    rs1387201,2
    C--35693591(+) ACCAC-/GGCGC 
     CCACCAC
    CACGC
    1 -- us2k11Minor allele frequency- GGCGCCCACCAC:0.00NA 2
    rs1387211,2
    C,F,A,H--35693744(-) TGGCTG/CACACC 1 -- us2k13Minor allele frequency- C:0.17NA 6

    HapMap Linkage Disequilibrium report for TOM1 (35695268 - 35743987 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TOM1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv3610CNV Insertion18451855
    nsv914995CNV Loss21882294
    nsv914994CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604700    OMIM disorders: --

    5 diseases for TOM1:    About MalaCards
    chronic wasting disease    adult acute lymphocytic leukemia    acute lymphocytic leukemia    cystic fibrosis
    leukemia


    TOM1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for TOM1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 15056867 (2)

    Genetic Association Database (GAD): TOM1
    Human Genome Epidemiology (HuGE) Navigator: TOM1 (1 document)

    Export disorders for TOM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TOM1 gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with TOM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM. (PubMed id 10329004)1, 2, 3, 9 Seroussi E....Dumanski J.P. (1999)
    2. Endofin recruits TOM1 to endosomes. (PubMed id 14613930)1, 2, 9 Seet L.-F.... Hong W. (2004)
    3. Structure of the VHS domain of human Tom1 (target of myb 1): insights into interactions with proteins and membranes. (PubMed id 10985773)1, 2, 9 Misra S.... Hurley J.H. (2000)
    4. Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1. (PubMed id 17671966)1, 4 Potash J.B....McMahon F.J. (2008)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    8. Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes. (PubMed id 15047686)1, 3 Katoh Y....Nakayama K. (2004)
    9. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    10. Endofin recruits clathrin to early endosomes via TOM1. (PubMed id 15657082)1, 9 Seet L.F. and Hong W. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10043 HGNC: 11982 AceView: TOM1 Ensembl:ENSG00000100284 euGenes: HUgn10043
    ECgene: TOM1 H-InvDB: TOM1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TOM1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TOM1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TOM1 gene:
    Search GeneIP for patents involving TOM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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