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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TOM1 Gene

protein-coding GIFtS: 61
GCID: GC22P035695

target of myb1 (chicken)

(Previous name: target of myb1 (chicken) homolog )

Explore 8 diseases affiliated with
TOM1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Target Of Myb1 (Chicken)¹ ²
Target Of Myb1 (Chicken) Homolog¹
Target Of Myb 1²
Target Of Myb Protein 1²

External Ids:	HGNC: 11982¹	Entrez Gene: 10043²	Ensembl: ENSG00000100284⁷	OMIM: 604700⁵	UniProtKB: O60784³

ORGUL members:
	NONCODE:n406661

Export aliases for TOM1 gene to outside databases

Previous GC identifers: GC22P032391 GC22P034020 GC22P018656

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TOM1:

This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common

with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its

interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been

found for this gene. (provided by RefSeq, Oct 2008)

UniProtKB/Swiss-Prot: TOM1_HUMAN, O60784

Function: May be involved in intracellular trafficking. Probable association with membranes

Gene Wiki entry for TOM1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TOM1 gene promoter:
Sox5 AP-1 ATF-2 c-Jun YY1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TOM1 promoter sequence

Search SABiosciences Chromatin IP Primers for TOM1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOM1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q12.3 HGNC cytogenetic band: 22q13.1

TOM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOM1 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P035695: view genomic region (about GC identifiers)

Start:	35,695,268 bp from pter	End:	35,743,987 bp from pter
Size:	48,720 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TOM1_HUMAN, O60784 (See protein sequence)

Recommended Name: Target of Myb protein 1

Size: 492 amino acids; 53818 Da

Subunit: Interacts with ZFYVE16; interaction is required to target it to endosomes

Subcellular location: Cytoplasm (Probable). Membrane; Peripheral membrane protein (Probable)

2 PDB 3D structures from and Proteopedia for TOM1:

1ELK (3D)

1WRD (3D)

Secondary accessions: B4DEL9 B4DNA1 Q5TIJ6 Q86X74

Alternative splicing: 4 isoforms: O60784-1 O60784-2 O60784-3 O60784-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TOM1: NX_O60784

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O60784

TOM1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001129201.1 NP_001129202.1 NP_001129204.1 NP_005479.1

ENSEMBL proteins:

ENSP00000393714 ENSP00000394466 ENSP00000385906 ENSP00000338422 ENSP00000394944

ENSP00000397492 ENSP00000379085 ENSP00000390429 ENSP00000389789 ENSP00000413697

ENSP00000394924 ENSP00000402556 ENSP00000398876 ENSP00000371465

Human Recombinant Protein Products for TOM1:

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	Novus Biologicals TOM1 Proteins Novus Biologicals TOM1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TOM1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005769	early endosome	IDA	14613930
GO:0005829	cytosol	IDA	14613930
GO:0016020	membrane	IDA	14613930

TOM1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for TOM1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TOM1 for domains About GeneDecksing

5 InterPro domains/families:

IPR002014 VHS

IPR004152 GAT

IPR018205 VHS_subgr

IPR008942 ENTH_VHS

IPR014645 TOM1

Graphical View of Domain Structure for InterPro Entry O60784

ProtoNet protein and cluster: O60784

2 Blocks protein families:

IPB002014 VHS

IPB004152 GAT domain

UniProtKB/Swiss-Prot: TOM1_HUMAN, O60784

Similarity: Belongs to the TOM1 family

Similarity: Contains 1 GAT domain

Similarity: Contains 1 VHS domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TOM1_HUMAN, O60784

Function: May be involved in intracellular trafficking. Probable association with membranes

Genatlas biochemistry entry for TOM1:

target of mybl (chicken ortholog),ubiquitous with highest expression in skeletal muscle,placenta,heart,liver,involved

in the control of vesicular trafficking to lysosome (suppression of cell growth)

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	14613930

TOM1 for ontologies About GeneDecksing

Phenotypes:
5 GenomeRNAi human phenotypes for TOM1:

Decreased Salmonella enterica	Decreased Salmonella enterica	Decreased Salmonella enterica	Decreased Salmonella enterica
Decreased Salmonella-containin

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TOM1

miRNA Products:		miRTarBase miRNAs that target TOM1: hsa-mir-126 (MIRT000967)

		OriGene 3'-UTR Clone (see all 4): TOM1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TOM1
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate TOM1 (see all 16):
		hsa-miR-126 hsa-miR-34c-5p hsa-miR-449b hsa-miR-449a hsa-miR-650 hsa-miR-124 hsa-miR-34a hsa-miR-2116*

		SwitchGear 3'UTR luciferase reporter plasmid: TOM1 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOM1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

C-MYB transcription factor network

C-MYB transcription factor network

1.00

1 BioSystems Pathway for TOM1

C-MYB transcription factor network

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TOM1

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

5/22 Interacting proteins for TOM1 (O60784^{1, 2, 3} ENSP00000413697⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 22)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TOM1L1	O75674²^,³, ENSP00000408958⁴	MINT-7980618 MINT-7980599 I2D: score=1 STRING: ENSP00000408958
ZFYVE16	Q7Z3T8¹^,³, ENSP00000337159⁴	EBI-74634,EBI-298055 I2D: score=5 STRING: ENSP00000337159
ZNF512B	Q96KM6²^,³	MINT-60835 I2D: score=2
HGS	O14964²^,³, ENSP00000331201⁴	MINT-58566 I2D: score=1 STRING: ENSP00000331201
IL1R1	P14778³, ENSP00000233946⁴	I2D: score=1 STRING: ENSP00000233946

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006886	intracellular protein transport	IEA	--
GO:0006897	endocytosis	NAS	10329004
GO:0015031	protein transport	NAS	14613930
GO:0016197	endosomal transport	TAS	10329004

TOM1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TOM1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TOM1
2 Novoseek chemical compound relationships for TOM1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
propanil	90.2	4	10329004 (2), 14563850 (1), 14613930 (1)
tyrosine	8.87	1	10329004 (1)

Search CenterWatch for drugs/clinical trials and news about TOM1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TOM1 gene (4 alternative transcripts):

NM_001135729.1 NM_001135730.1 NM_001135732.1 NM_005488.2

Unigene Cluster for TOM1:

Target of myb1 (chicken)

Hs.474705 [show with all ESTs]

Unigene Representative Sequence: AK097926

18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):

ENST00000456128 ENST00000449058 ENST00000404284(uc003ano.3) ENST00000465529

ENST00000337040 ENST00000487670 ENST00000439512 ENST00000424387 ENST00000395736

ENST00000449508 ENST00000443206 ENST00000497448 ENST00000491987 ENST00000492723

ENST00000411850(uc011amj.2 uc003anp.3 uc003ann.3 uc011amk.2)

ENST00000425375(uc011aml.2) ENST00000436462 ENST00000447733(uc011ami.2)

miRNA Products:		OriGene 3'-UTR Clone (see all 4): TOM1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TOM1
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate TOM1 (see all 16):
		hsa-miR-126 hsa-miR-34c-5p hsa-miR-449b hsa-miR-449a hsa-miR-650 hsa-miR-124 hsa-miR-34a hsa-miR-2116*

		SwitchGear 3'UTR luciferase reporter plasmid: TOM1 3' UTR sequence

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Additional cDNA sequence:

AF040251.1 AJ006973.1 AK026576.1 AK090723.1 AK091958.1 AK097066.1 AK097926.1 AK293694.1

AK295918.1 AK296670.1 AK297827.1 AK314522.1 AY358980.1 BC040006.1 BC046151.1 CR456595.1

NR_024194.1 NR_024195.1

24/33 DOTS entries (see all 33):

DT.117662 DT.99937389 DT.120669866 DT.100879921 DT.100879933 DT.100879929 DT.95242925 DT.100879939

DT.120669875 DT.120669870 DT.100028876 DT.100879925 DT.100879940 DT.100879920 DT.100879930 DT.92431542

DT.100879937 DT.100879938 DT.120669854 DT.120669896 DT.91979131 DT.100801815 DT.100879934 DT.100879936

24/354 AceView cDNA sequences (see all 354):

AI610200 CB215604 BU069230 CR596343 AI224382 BC046151 BE139562 CF139315

BX388271 CR608920 BQ937460 BX361023 BQ956663 BM808757 BX366226 BP344592

AL041625 BX430436 F10736 CR595971 AJ006973 BQ896596 BQ051481 BC040006

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TOM1 (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	^	16	^	17a	·	17b
SP1:									-						-				-		-																				-
SP2:									-		-				-				-		-										-										-
SP3:									-		-				-				-		-										-										-
SP4:									-		-				-
SP5:									-		-

ECgene alternative splicing isoforms for TOM1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TOM1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTTTGGCTG

About this image
See TOM1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TOM1

SOURCE GeneReport for Unigene cluster: Hs.474705

UniProtKB/Swiss-Prot: TOM1_HUMAN, O60784

Tissue specificity: Widely expressed. Highly expressed in skeletal muscle, heart, placenta and liver

SABiosciences Custom PCR Arrays for TOM1

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOM1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TOM1 gene from 8/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TOM1¹	target of myb1 (chicken)	75.7(n) 78.44(a)		396049 NM_205144.1 NP_990475.1
lizard (Anolis carolinensis)	Reptilia	-- --	--	77(a) 68(a)	1 ↔ many 1 ↔ many	5(21438759-21449001) 5(21449005-21465009)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.15040²	Transcribed sequence with weak similarity to protein more	76.53(n)		CF783101.1
zebrafish (Danio rerio)	Actinopterygii	BC056566.1²	--	78.82(n)		BC056566.1
fruit fly (Drosophila melanogaster)	Insecta	CG3529³	--	41(a)		67B5 --
worm (Caenorhabditis elegans)	Secernentea	C07A12.7b³ C07A12.7¹	Protein C07A12.7¹	48(a) (best of 2)³ 54.9(n)¹ 50.74(a)¹		X(4553182-4556331)³ 180723¹ NM_076376.3¹ NP_508777.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G76970⁶ AT1G21380⁶ (see all 9)	Target of Myb protein 1 (see all 9)	20(a) 19(a) (see all 9)	many ↔ many many ↔ many (see all 9)	1(28922666-28925404) 1(7485636-7488713)
rice (Oryza sativa)	Liliopsida	-- -- (see all 10)	VHS and GAT domain containing protein, expressed (see all 10)	18(a) 18(a) (see all 10)	many ↔ many many ↔ many (see all 10)	2(28667133-28671003) 10(22980611-22983543)

ENSEMBL Gene Tree for TOM1 (if available)
TreeFam Gene Tree for TOM1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TOM1 gene

GGA2² TOM1L2² TOM1L1² GGA1² GGA3²

6 SIMAP similar genes for TOM1 using alignment to 10 protein entries: TOM1_HUMAN (see all proteins):

TOM1L2 TOM1L1 GGA3 GGA2 HGS GGA1

TOM1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs76951410^1,2	C	--	35693273(+)	`AAGAGG/TCTGAA`	1	--	us2k¹		1		WA	2
rs143858975^1,2		--	35693340(+)	`CTGTAA/CGCCAG`	1	--	us2k¹		0	--	--	--	--
rs138719^1,2	C	--	35693373(+)	`TTTAA-/AAAT AAATA`	1	--	us2k¹ tfbs³		1		NA	2
rs67125942^1,2	C	--	35693373(+)	`TTTAAAAAT/- AAATA`	1	--	us2k¹		1		CSA	2
rs148616315^1,2		--	35693417(+)	`TTTCAA/GTAGCT`	1	--	us2k¹		0	--	--	--	--
rs11705224^1,2	C,H	--	35693507(+)	`GCAGTA/GGTGCA`	1	--	us2k¹		1		CSA	1
rs188062985^1,2		--	35693535(+)	`GCTCCA/GCCTAC`	1	--	us2k¹		0	--	--	--	--
rs138720^1,2	C	--	35693591(+)	`ACCAC-/GGCGC CCACCACCACGC`	1	--	us2k¹		1		NA	2
rs138721^1,2	C,A,H	--	35693744(-)	`TGGCTG/CACACC`	1	--	us2k¹		3		NA	6
rs138722^1,2	C,F,O,A,H	--	35693778(-)	`GTGGAA/GTCATA`	1	--	us2k¹ tfbs³		13		NA WA CSA EA	512

HapMap Linkage Disequilibrium report for TOM1 (35695268 - 35743987 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TOM1
1 CNV: 36019

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TOM1 for disorders           About GeneDecksing

OMIM gene information: 604700    OMIM disorders: --

8 diseases for TOM1:    About MalaCards

adult acute lymphocytic leukemia bipolar affective disorder chronic wasting disease acute lymphocytic leukemia

lymphocytic leukemia cystic fibrosis fibrosis leukemia

1 Novoseek disease relationship for TOM1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	3	15056867 (2)

Human Genome Epidemiology (HuGE) Navigator: TOM1 (1 document)

Export disorders for TOM1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TOM1 gene, integrated from 9 sources (see all 46):
(articles sorted by number of sources associating them with TOM1)

Utopia: connect your pdf to the dynamic
world of online information

TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM. (PubMed id 10329004)^{1, 2, 3, 9} Seroussi E....Dumanski J.P. (1999)
Endofin recruits TOM1 to endosomes. (PubMed id 14613930)^{1, 2, 9} Seet L.-F.... Hong W. (2004)
Structure of the VHS domain of human Tom1 (target of myb 1): insights into interactions with proteins and membranes. (PubMed id 10985773)^{1, 2, 9} Misra S.... Hurley J.H. (2000)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (2004)
Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes. (PubMed id 15047686)^{1, 3} Katoh Y....Nakayama K. (2004)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I....O'Brien K.P. (1999)
Endofin recruits clathrin to early endosomes via TOM1. (PubMed id 15657082)^{1, 9} Seet L.F. and Hong W. (2005)
miR-126 is downregulated in cystic fibrosis airway ep ithelial cells and regulates TOM1 expression. (PubMed id 20083669)^{1, 9} Oglesby I.K....Greene C.M. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10043	HGNC: 11982	AceView: TOM1	Ensembl:ENSG00000100284	euGenes: HUgn10043
ECgene: TOM1	H-InvDB: TOM1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TOM1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TOM1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TOM1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TOM1 gene:
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GeneCards and IP:
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