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Aliases for TOLLIP Gene

Aliases for TOLLIP Gene

  • Toll Interacting Protein 2 3
  • Toll-Interacting Protein 3
  • Adapter Protein 3
  • IL-1RAcPIP 3

External Ids for TOLLIP Gene

Summaries for TOLLIP Gene

Entrez Gene Summary for TOLLIP Gene

  • This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. [provided by RefSeq, Aug 2011]

GeneCards Summary for TOLLIP Gene

TOLLIP (Toll Interacting Protein) is a Protein Coding gene. Among its related pathways are NF-KappaB Family Pathway and NF-KappaB Family Pathway. GO annotations related to this gene include signal transducer activity and kinase binding.

UniProtKB/Swiss-Prot for TOLLIP Gene

  • Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851).

Gene Wiki entry for TOLLIP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOLLIP Gene

Genomics for TOLLIP Gene

Genomic Location for TOLLIP Gene

Start:
1,274,368 bp from pter
End:
1,309,662 bp from pter
Size:
35,295 bases
Orientation:
Minus strand

Genomic View for TOLLIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TOLLIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOLLIP Gene

Regulatory Elements for TOLLIP Gene

Proteins for TOLLIP Gene

  • Protein details for TOLLIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0E2-TOLIP_HUMAN
    Recommended name:
    Toll-interacting protein
    Protein Accession:
    Q9H0E2
    Secondary Accessions:
    • B3KXC6
    • Q9H9E6
    • Q9UJ69

    Protein attributes for TOLLIP Gene

    Size:
    274 amino acids
    Molecular mass:
    30282 Da
    Quaternary structure:
    • Oligomerizes. Binds to TLR2 and the TLR4-MD2 complex via its C-terminus. Exists as complex with IRAK1 in unstimulated cells. Upon IL-1 signaling, Tollip binds to the activated IL-1 receptor complex containing IL-1RI, IL-1RacP and the adapter protein MyD88, where it interacts with the TIR domain of IL-1RacP. MyD88 then triggers IRAK1 autophosphorylation, which in turn leads to the dissociation of IRAK1 from Tollip and IL-1RAcP. Interacts with TOM1L2. Interacts with ATG8 family proteins (via AIM motifs), and ubiquitin (via CUE domain).
    SequenceCaution:
    • Sequence=BAB14283.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TOLLIP Gene

    Alternative splice isoforms for TOLLIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TOLLIP Gene

Proteomics data for TOLLIP Gene at MOPED

Post-translational modifications for TOLLIP Gene

  • Phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys63, Lys66, Lys96, Lys102, Lys146, and Lys150

Other Protein References for TOLLIP Gene

No data available for DME Specific Peptides for TOLLIP Gene

Domains for TOLLIP Gene

Protein Domains for TOLLIP Gene

UniProtKB/Swiss-Prot:

TOLIP_HUMAN
Domain:
  • Both ATG8-interaction motifs (AIM1 and AIM2) are required for the association with ATG8 family proteins.:
    • Q9H0E2
  • Contains 1 C2 domain.:
    • Q9H0E2
  • Contains 1 CUE domain.:
    • Q9H0E2
Family:
  • Belongs to the tollip family.:
    • Q9H0E2
genes like me logo Genes that share domains with TOLLIP: view

No data available for Gene Families for TOLLIP Gene

Function for TOLLIP Gene

Molecular function for TOLLIP Gene

UniProtKB/Swiss-Prot Function: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851).

Gene Ontology (GO) - Molecular Function for TOLLIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity NAS 11441107
GO:0005150 interleukin-1, Type I receptor binding IEA --
GO:0005515 protein binding IPI 14563850
GO:0019900 kinase binding IPI 10854325
GO:0031624 ubiquitin conjugating enzyme binding IEA --
genes like me logo Genes that share ontologies with TOLLIP: view
genes like me logo Genes that share phenotypes with TOLLIP: view

Animal Models for TOLLIP Gene

MGI Knock Outs for TOLLIP:

miRNA for TOLLIP Gene

miRTarBase miRNAs that target TOLLIP

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TOLLIP Gene

Localization for TOLLIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOLLIP Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TOLLIP Gene COMPARTMENTS Subcellular localization image for TOLLIP gene
Compartment Confidence
plasma membrane 5
cytosol 4
endosome 2
nucleus 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TOLLIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IC 11441107
GO:0005829 cytosol TAS --
GO:0016604 nuclear body IEA --
GO:0045092 interleukin-18 receptor complex NAS 10854325
GO:0045323 interleukin-1 receptor complex NAS 10854325
genes like me logo Genes that share ontologies with TOLLIP: view

Pathways for TOLLIP Gene

genes like me logo Genes that share pathways with TOLLIP: view

Gene Ontology (GO) - Biological Process for TOLLIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0006954 inflammatory response NAS 10854325
GO:0007165 signal transduction IPI 11441107
GO:0007267 cell-cell signaling TAS 10854325
GO:0016310 phosphorylation IDA 1085432
genes like me logo Genes that share ontologies with TOLLIP: view

Compounds for TOLLIP Gene

(30) Novoseek inferred chemical compound relationships for TOLLIP Gene

Compound -log(P) Hits PubMed IDs
tyrosine 74.3 67
phosphotyrosine 62.8 7
phosphatidylinositol 3-phosphate 43.9 1
phosphatidylinositol 43.6 7
letrozole 43.3 5
genes like me logo Genes that share compounds with TOLLIP: view

Transcripts for TOLLIP Gene

Unigene Clusters for TOLLIP Gene

Toll interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TOLLIP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d · 12e ·
SP1: - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - -
SP7: - -
SP8: - - - - - - - - - - - - - - -
SP9: - - - - -
SP10: - - - - - -
SP11:
SP12: - - -
SP13: - -

ExUns: 12f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for TOLLIP Gene

GeneLoc Exon Structure for
TOLLIP
ECgene alternative splicing isoforms for
TOLLIP

Expression for TOLLIP Gene

mRNA expression in normal human tissues for TOLLIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TOLLIP Gene

SOURCE GeneReport for Unigene cluster for TOLLIP Gene Hs.368527

genes like me logo Genes that share expressions with TOLLIP: view

Orthologs for TOLLIP Gene

This gene was present in the common ancestor of animals.

Orthologs for TOLLIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOLLIP 36
  • 87.75 (n)
  • 85.61 (a)
cow
(Bos Taurus)
Mammalia TOLLIP 36
  • 88.6 (n)
  • 92.28 (a)
TOLLIP 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TOLLIP 36
  • 87.79 (n)
  • 92.31 (a)
TOLLIP 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tollip 36
  • 86.08 (n)
  • 93.04 (a)
Tollip 16
Tollip 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TOLLIP 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TOLLIP 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tollip 36
  • 85.84 (n)
  • 93.41 (a)
chicken
(Gallus gallus)
Aves TOLLIP 36
  • 78.51 (n)
  • 89.38 (a)
TOLLIP 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TOLLIP 37
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tollip 36
  • 74.63 (n)
  • 81.72 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.8875 36
tollip 36
  • 76.47 (n)
  • 83.82 (a)
tollip 37
  • 81 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003615 36
  • 59.21 (n)
  • 52.03 (a)
worm
(Caenorhabditis elegans)
Secernentea tli-1 36
  • 49.34 (n)
  • 44.1 (a)
tli-1 37
  • 40 (a)
OneToOne
F25H2.1 38
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6903 37
  • 37 (a)
OneToOne
Species with no ortholog for TOLLIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TOLLIP Gene

ENSEMBL:
Gene Tree for TOLLIP (if available)
TreeFam:
Gene Tree for TOLLIP (if available)

Paralogs for TOLLIP Gene

No data available for Paralogs for TOLLIP Gene

Variants for TOLLIP Gene

Sequence variations from dbSNP and Humsavar for TOLLIP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs908225 -- 1,291,999(+) TCTAA(C/T)CAAAG intron-variant
rs2271599 -- 1,298,116(+) AGACT(C/T)GTGCT intron-variant
rs2292635 -- 1,289,915(+) TGTCC(C/T)TGGAA intron-variant
rs3168046 -- 1,275,419(-) TCAGG(C/T)GGGAC utr-variant-3-prime
rs3750920 -- 1,288,726(+) GACTC(C/T)GGGAT synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for TOLLIP Gene

Variant ID Type Subtype PubMed ID
nsv469923 CNV Loss 18288195
esv2743878 CNV Deletion 23290073
esv2669189 CNV Deletion 23128226
essv22587 CNV CNV 17122850
nsv896644 CNV Loss 21882294
dgv963n71 CNV Loss 21882294
dgv966n71 CNV Loss 21882294
dgv967n71 CNV Loss 21882294
dgv968n71 CNV Loss 21882294
dgv969n71 CNV Loss 21882294
dgv970n71 CNV Loss 21882294
nsv467637 CNV Loss 19166990
dgv971n71 CNV Loss 21882294
dgv972n71 CNV Loss 21882294
nsv825693 CNV Gain 20364138
nsv825694 CNV Gain 20364138
nsv896687 CNV Loss 21882294
dgv973n71 CNV Loss 21882294
esv1170595 CNV Insertion 17803354
esv1001632 CNV Deletion 20482838
nsv818794 CNV Loss 17921354
esv21758 CNV Gain 19812545
nsv39591 CNV Loss 16902084
esv1673155 CNV Deletion 17803354
esv1056483 CNV Deletion 17803354
esv2743907 CNV Deletion 23290073

Relevant External Links for TOLLIP Gene

HapMap Linkage Disequilibrium report
TOLLIP

Disorders for TOLLIP Gene

(16) Novoseek inferred disease relationships for TOLLIP Gene

Disease -log(P) Hits PubMed IDs
lymphoproliferative syndrome 49.1 3
x-linked lymphoproliferative syndrome 49 1
necrosis 36.4 14
tumors 30.8 26
myeloid leukemia chronic 19.4 1

Relevant External Links for TOLLIP

Genetic Association Database (GAD)
TOLLIP
Human Genome Epidemiology (HuGE) Navigator
TOLLIP
genes like me logo Genes that share disorders with TOLLIP: view

No data available for UniProtKB/Swiss-Prot for TOLLIP Gene

Publications for TOLLIP Gene

  1. Tollip, a new component of the IL-1R1 pathway, links IRAK to the IL-1 receptor. (PMID: 10854325) Burns K. … Volpe F. (Nat. Cell Biol. 2000) 2 3 4 23
  2. Recruitment of clathrin onto endosomes by the Tom1-Tollip complex. (PMID: 16412388) Katoh Y. … Nakayama K. (Biochem. Biophys. Res. Commun. 2006) 3 4 23
  3. Association of toll-interacting protein gene polymorphisms with atopic dermatitis. (PMID: 17362526) Schimming T.T. … Hoffjan S. (BMC Dermatol. 2007) 3 23 49
  4. Negative regulation of Toll-like receptor-mediated signaling by Tollip. (PMID: 11751856) Zhang G. … Ghosh S. (J. Biol. Chem. 2002) 3 4 23
  5. Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination. (PMID: 18987746) Kimman T.G. … Kerkhof M. (PLoS ONE 2008) 3 23 49

Products for TOLLIP Gene

Sources for TOLLIP Gene

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