TOLLIP Gene
protein-coding GIFtS: 61
GCID: GC11M001295
|
|
toll interacting protein
| |
Aliases
for TOLLIP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Toll Interacting Protein1 2 | | IL-1RAcPIP1 2 | | Adapter Protein2 | | Toll-Interacting Protein2 |
Export aliases for TOLLIP gene to outside databasesPrevious GC identifers: GC11M001759 GC11M001558 GC11M001261 GC11M001262 GC11M001252 GC11M001087 |
Summaries
for TOLLIP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TOLLIP:
This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascadecomponents. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor traffickingand in the turnover of IL1R-associated kinase. (provided by RefSeq, Aug 2011)
UniProtKB/Swiss-Prot: TOLIP_HUMAN, Q9H0E2Function: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbialproducts. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity
Gene Wiki entry for TOLLIP
|
Genomic Views
for TOLLIP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TOLLIP gene promoter:
AhR Elk-1 STAT1 Sp1 ATF-2 FOXD1 AP-4 ATF GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TOLLIP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOLLIP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11pTOLLIP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M001295: view genomic region
(about GC identifiers)
Start:
|
1,295,598 bp from pter |
End:
|
1,330,892 bp from pter |
Size:
|
35,295 bases |
Orientation:
|
minus strand |
|
Proteins
for TOLLIP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TOLIP_HUMAN, Q9H0E2 (See
protein sequence)Recommended Name: Toll-interacting protein Size: 274 amino acids; 30282 Da
Subunit: Oligomerizes. Binds to TLR2 and the TLR4-MD2 complex via its C-terminus. Exists as complex with IRAK1 inunstimulated cells. Upon IL-1 signaling, Tollip binds to the activated IL-1 receptor complex containing IL-1RI,IL-1RacP and the adapter protein MyD88, where it interacts with the TIR domain of IL-1RacP. MyD88 then triggers IRAK1autophosphorylation, which in turn leads to the dissociation of IRAK1 from Tollip and IL-1RAcP. Interacts with TOM1L2
Subcellular location: Cytoplasm (Probable)
Sequence caution: Sequence=BAB14283.1; Type=Erroneous initiation;
1 PDB 3D structure from  and Proteopedia  for TOLLIP:1WGL (3D)
Secondary accessions: Q9H9E6 Q9UJ69Explore the universe of human proteins at neXtProt for TOLLIP: NX_Q9H0E2
Post-translational modifications:
Phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H0E2
TOLLIP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061882.2
ENSEMBL proteins: ENSP00000314733 ENSP00000434035 ENSP00000432668 ENSP00000263646 ENSP00000436393 ENSP00000432778 ENSP00000434494 ENSP00000437404 Reactome Protein details: Q9H0E2
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
TOLLIP for ontologies About GeneDecksing
TOLLIP Antibody Products:
Assay Products for TOLLIP: |
Protein
Domains /
Families
for TOLLIP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TOLLIP for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H0E2ProtoNet protein and cluster: Q9H0E2 2 Blocks protein families: IPB000008 C2 domain IPB003892 Ubiquitin system component Cue
UniProtKB/Swiss-Prot: TOLIP_HUMAN, Q9H0E2Similarity: Belongs to the tollip familySimilarity: Contains 1 C2 domainSimilarity: Contains 1 CUE domain |
Function
for TOLLIP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TOLIP_HUMAN, Q9H0E2Function: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbialproducts. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOLLIP (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOLLIP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TOLLIP (NM_019009) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TOLLIP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOLLIP |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOLLIP |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
TOLLIP for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for TOLLIP:
Animal Models:
Mouse knock-out Tolliptm1Kbns for TOLLIP
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Tollip):
TOLLIP for phenotypes About GeneDecksing
|
Pathways & Interactions
for TOLLIP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune response_IL-1 signaling pathway | | | 2 | Interleukin-1 signaling | | | 3 | Transcription NF-kB signaling pathway | | | 4 | Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response | | | 5 | TRAF Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for TOLLIP
5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TOLLIP
1 
Cell Signaling Technology (CST) Pathway for TOLLIP
4  GeneGo (Thomson Reuters) Pathways for TOLLIP
3  BioSystems Pathways for TOLLIP
5 
Reactome Pathways for TOLLIP
1 
Kegg Pathway (Kegg details for TOLLIP):
TOLLIP for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TOLLIP
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/95 Interacting proteins for TOLLIP (Q9H0E21, 3 ENSP000003147334) via UniProtKB, MINT, STRING, and/or I2D (see all 95)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| TOM1L1 | O756741, 3, ENSP000004089584 | EBI-74615,EBI-712991 I2D:
score=4 STRING: ENSP00000408958 | | IRAK2 | O431871, 3, ENSP000002564584 | EBI-74615,EBI-447733 I2D:
score=1 STRING: ENSP00000256458 | | PEG10 | Q86TG71, 3, ENSP000004175874 | EBI-74615,EBI-2858265 I2D:
score=1 STRING: ENSP00000417587 | | WRNIP1 | Q96S551, 3, ENSP000003701504 | EBI-74615,EBI-2513471 I2D:
score=1 STRING: ENSP00000370150 | | DAZAP2 | Q150381, 3, ENSP000004049684 | EBI-74615,EBI-724310 I2D:
score=3 STRING: ENSP00000404968 |
About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
TOLLIP for ontologies About GeneDecksing
|
Drugs & Compounds
for TOLLIP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TOLLIP for compounds About GeneDecksing
 Browse Tocris compounds for TOLLIP
10/30 Novoseek chemical compound relationships for TOLLIP gene (see all 30) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
74.3 |
79 |
9678765 (2), 17855441 (2), 9199344 (1), 10026169 (1) (see all 65) |
| phosphotyrosine |
62.8 |
7 |
9482841 (1), 9710592 (1), 9737716 (1), 15737992 (1) (see all 7) |
| phosphatidylinositol 3-phosphate |
43.9 |
2 |
15140579 (1) |
| phosphatidylinositol |
43.6 |
9 |
19330070 (1), 17651088 (1), 7499252 (1), 15202725 (1) (see all 7) |
| letrozole |
43.3 |
5 |
15967659 (1), 17113978 (1), 17611101 (1), 15701882 (1) (see all 5) |
| phosphoinositide |
37 |
1 |
12521378 (1) |
| phosphatidylinositol-3,4,5-trisphosphate |
36.9 |
1 |
16172125 (1) |
| ly294002 |
22.9 |
1 |
12621049 (1) |
| inositol |
22.1 |
1 |
9013643 (1) |
| threonine |
21.7 |
4 |
10854325 (1), 17276401 (1), 17625596 (1), 16107720 (1) |
Search CenterWatch for drugs/clinical trials and news about TOLLIP / TOLIP
|
Transcripts
for TOLLIP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TOLLIP gene: NM_019009.3 Unigene Cluster for TOLLIP: Toll interacting protein Hs.368527 [show with all ESTs]Unigene Representative Sequence: NM_01900914 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000317204(uc001lte.3 uc009ycu.3 uc001ltf.3) ENST00000527886(uc001ltd.3)
ENST00000525159 ENST00000263646 ENST00000530506 ENST00000527938 ENST00000530541
ENST00000528719 ENST00000527746 ENST00000527638 ENST00000532551 ENST00000530821
ENST00000527085 ENST00000542915
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOLLIP (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOLLIP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TOLLIP (NM_019009) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TOLLIP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOLLIP |
Additional cDNA sequence: AB209541.1 AJ242972.1 AK022871.1 AK090850.1 AK096693.1 AK127123.1 AK315592.1 AL136835.1 AY730683.1 BC004420.1 BC012057.1 BC018272.1 CR533477.1 15 DOTS entries: DT.120714802 DT.100793245 DT.444846 DT.100809199 DT.100705767 DT.102842608 DT.100793235 DT.100793236 DT.100793239 DT.120714755 DT.120714800 DT.75195364 DT.97846496 DT.100793243 DT.120714773 24/305 AceView cDNA sequences (see all 305): BQ961826 CF145912 BE795865 AL136835 BC004420 AI278273 AW027877 BE047886 BM069752 BX441711 AA363771 AI288458 AA360511 AI686617 BE796029 BM915457 AI215164 AW294495 BX366329 CA309889 BE675106 BU195369 AI880708 BI825192
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for TOLLIP (see all 13) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | · | 12d | · | 12e | · |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | | | | | - | | - | | - | | | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | | | | | - | | - | | - | | - | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 12f |
|---|
|
| SP1: | | | |
| SP2: | | | |
| SP3: | | | |
| SP4: | | | |
| SP5: | | |
ECgene alternative splicing isoforms for TOLLIP
|
Expression
for TOLLIP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TOLLIP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCGTTCTGGA
About this image
See TOLLIP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TOLLIP
SOURCE GeneReport for Unigene cluster: Hs.368527
SABiosciences Expression via Pathway-Focused PCR Arrays including TOLLIP (see all 7):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOLLIP
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TOLLIP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOLLIP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOLLIP | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOLLIP |
Orthologs
for TOLLIP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TOLLIP gene from 6/19 species (see all 19) About this table
ENSEMBL Gene Tree for TOLLIP (if available)
TreeFam Gene Tree for TOLLIP (if available) |
Paralogs
for TOLLIP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TOLLIP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TOLLIP (1295598 - 1330892 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for TOLLIP
5 CNVs: 3831 10344 29887 65837 29888
6 Indels: 24650 85588 75492 24649 75493 85589 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOLLIP |
|
Disorders
/ Diseases
for TOLLIP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TOLLIP for disorders About GeneDecksing
OMIM gene information: 606277
OMIM disorders: --
20/27  diseases for TOLLIP (see all 27): About MalaCardslymphoproliferative syndrome cervical squamous cell carcinoma squamous cell carcinoma inflammatory bowel disease
atopic dermatitis chronic lymphocytic leukemia lymphocytic leukemia down syndrome
dermatitis huntington's disease hepatitis b breast cancer
leukemia pertussis twinning cervicitis
carcinoma meningioma melanoma lung cancer
10/16 Novoseek disease relationships for TOLLIP gene (see all 16) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| lymphoproliferative syndrome |
49.1 |
3 |
12242590 (1), 15661030 (1), 12629654 (1) |
| x-linked lymphoproliferative syndrome |
49 |
1 |
16081788 (1) |
| necrosis |
36.4 |
16 |
9620659 (1), 9744859 (1), 10964568 (1), 11784851 (1) (see all 14) |
| tumors |
30.8 |
28 |
15299064 (1), 9620659 (1), 9744859 (1), 10449755 (1) (see all 26) |
| myeloid leukemia chronic |
19.4 |
1 |
19966867 (1) |
| breast cancer |
9.52 |
3 |
17855441 (2), 15322292 (1) |
| cancer |
0.239 |
6 |
16787325 (1), 18620523 (1), 16480678 (1), 18451132 (1) (see all 6) |
| nephrotic syndrome |
0 |
1 |
12217865 (1) |
| breast carcinoma |
0 |
1 |
17218774 (1) |
| shock |
0 |
1 |
18035683 (1) |
Human Genome Epidemiology (HuGE) Navigator: TOLLIP (12 documents)
Export disorders for TOLLIP gene to outside databases
|
Publications
for TOLLIP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TOLLIP gene, integrated from 9 sources (see all 342):
(articles sorted by number of sources associating them with TOLLIP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Tollip, a new component of the IL-1R1 pathway, links IRAK to the IL-1 receptor. (PubMed id 10854325)1, 2, 3, 9 Burns K.... Volpe F. (2000)
- Negative regulation of Toll-like receptor-mediated signaling by Tollip. (PubMed id 11751856)1, 2, 9 Zhang G. and Ghosh S. (2002)
- Recruitment of clathrin onto endosomes by the Tom1-Tollip complex. (PubMed id 16412388)1, 2, 9 Katoh Y.... Nakayama K. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- The IL1 receptor accessory protein is responsible for the recruitment of the interleukin-1 receptor associated kinase to the IL1/IL1 receptor I complex. (PubMed id 9426216)1, 3 Volpe F....Ray K. (1997)
- Diversification of TOLLIP isoforms in mouse and man. (PubMed id 19444506)1, 9 Lo Y.L....Wells C.A. (2009)
- Down syndrome candidate region-1 protein interacts wi th Tollip and positively modulates interleukin-1 receptor-mediated signaling. (PubMed id 19716405)1, 9 Lee J.Y....Chung K.C. (2009)
- Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes. (PubMed id 15047686)1, 9 Katoh Y....Nakayama K. (2004)
|
External Searches for TOLLIP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TOLLIP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing TOLLIP gene
(According to HUGE)
About This Section
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Specialized Databases showing TOLLIP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for TOLLIP | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for TOLLIP gene:
Search GeneIP for patents involving TOLLIP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TOLLIP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for TOLLIP | | OriGene shRNA RFP for TOLLIP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TOLLIP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOLLIP | | | OriGene Protein Over-expression Lysate for TOLLIP | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TOLLIP | | OriGene 3'-UTR Clone for TOLLIP | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOLLIP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOLLIP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TOLLIP | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TOLLIP | | OriGene Custom Protein Services for TOLLIP | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TOLLIP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOLLIP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOLLIP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOLLIP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOLLIP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOLLIP |
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| | Antibodies & Assays for TOLLIP |
| | | | Search Tocris compounds for TOLLIP |
| |  |  |  |  | | | | | | Recombinant Protein for TOLLIP |
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 | | | TOLLIP Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOLLIP |
|  |  |  | | | | ThermoFisher Antibody for TOLLIP |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOLLIP |
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