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TOLLIP Gene

protein-coding   GIFtS: 65
GCID: GC11M001295

Toll Interacting Protein

  Search for TOLLIP
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Toll Interacting Protein1 2
IL-1RAcPIP2
Adapter Protein2
Toll-Interacting Protein2

External Ids:    HGNC: 164761   Entrez Gene: 544722   Ensembl: ENSG000000789027   OMIM: 6062775   UniProtKB: Q9H0E23   

Export aliases for TOLLIP gene to outside databases

Previous GC identifers: GC11M001759 GC11M001558 GC11M001261 GC11M001262 GC11M001252 GC11M001087


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TOLLIP Gene:
This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling
cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1
receptor trafficking and in the turnover of IL1R-associated kinase. (provided by RefSeq, Aug 2011)

GeneCards Summary for TOLLIP Gene:
TOLLIP (toll interacting protein) is a protein-coding gene. GO annotations related to this gene include kinase binding and signal transducer activity.

UniProtKB/Swiss-Prot: TOLIP_HUMAN, Q9H0E2
Function: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by
microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase
activity

Gene Wiki entry for TOLLIP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the TOLLIP gene promoter:
         AhR   Elk-1   STAT1   Sp1   ATF-2   FOXD1   AP-4   ATF   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTOLLIP promoter sequence
   Search Chromatin IP Primers for TOLLIP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TOLLIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p

TOLLIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOLLIP gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M001295:  view genomic region     (about GC identifiers)

Start:
1,295,598 bp from pter      End:
1,330,892 bp from pter
Size:
35,295 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TOLIP_HUMAN, Q9H0E2 (See protein sequence)
Recommended Name: Toll-interacting protein  
Size: 274 amino acids; 30282 Da
Subunit: Oligomerizes. Binds to TLR2 and the TLR4-MD2 complex via its C-terminus. Exists as complex with IRAK1 in
unstimulated cells. Upon IL-1 signaling, Tollip binds to the activated IL-1 receptor complex containing IL-1RI,
IL-1RacP and the adapter protein MyD88, where it interacts with the TIR domain of IL-1RacP. MyD88 then triggers
IRAK1 autophosphorylation, which in turn leads to the dissociation of IRAK1 from Tollip and IL-1RAcP. Interacts
with TOM1L2
Sequence caution: Sequence=BAB14283.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for TOLLIP:
1WGL (3D)    
Secondary accessions: Q9H9E6 Q9UJ69

Explore the universe of human proteins at neXtProt for TOLLIP: NX_Q9H0E2

Explore proteomics data for TOLLIP at MOPED

Post-translational modifications: 

  • Phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products1
  • Ubiquitination2 at Lys63, Lys66, Lys96, Lys102, Lys146, Lys150
  • Modification sites at PhosphoSitePlus

  • See TOLLIP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061882.2  
    ENSEMBL proteins: 
     ENSP00000314733   ENSP00000434035   ENSP00000432668   ENSP00000263646   ENSP00000436393  
     ENSP00000432778   ENSP00000434494   ENSP00000437404  
    Reactome Protein details: Q9H0E2

    TOLLIP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for TOLLIP
    OriGene Protein Over-expression Lysate for TOLLIP
    OriGene MassSpec for TOLLIP
    OriGene Custom Protein Services for TOLLIP
    GenScript Custom Purified and Recombinant Proteins Services for TOLLIP
    Novus Biologicals TOLLIP Proteins
    Novus Biologicals TOLLIP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TOLLIP
    Cloud-Clone Corp. Proteins for TOLLIP

     
    Search eBioscience for Proteins for TOLLIP 

    TOLLIP Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TOLLIP
    R&D Systems Antibodies for TOLLIP
    Cell Signaling Technology (CST) Antibodies for TOLLIP 
    OriGene Antibodies for TOLLIP
    OriGene Custom Antibody Services for TOLLIP
    Novus Biologicals TOLLIP Antibodies
    Abcam antibodies for TOLLIP
    Cloud-Clone Corp. Antibodies for TOLLIP
    ThermoFisher Antibodies for TOLLIP
    LSBio Antibodies in human, mouse, rat for TOLLIP

    TOLLIP Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TOLLIP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TOLLIP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TOLLIP
    Cloud-Clone Corp. CLIAs for TOLLIP
    Search eBioscience for ELISAs for TOLLIP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR003892 CUE
     IPR000008 C2_dom
     IPR009060 UBA-like

    Graphical View of Domain Structure for InterPro Entry Q9H0E2

    ProtoNet protein and cluster: Q9H0E2

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB003892 Ubiquitin system component Cue


    UniProtKB/Swiss-Prot: TOLIP_HUMAN, Q9H0E2
    Similarity: Belongs to the tollip family
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 CUE domain


    Find genes that share domains with TOLLIP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TOLIP_HUMAN, Q9H0E2
    Function: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by
    microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase
    activity

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity NAS11441107
    GO:0005150interleukin-1, Type I receptor binding IEA--
    GO:0005515protein binding IPI16189514
    GO:0019900kinase binding IPI10854325
    GO:0031624ubiquitin conjugating enzyme binding IEA--
         
    Find genes that share ontologies with TOLLIP           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TOLLIP:
     Increased HPV18 LCR reporter a  Low eccentricity cells  Synthetic lethal with c-Myc af 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tollip):
     homeostasis/metabolism  immune system 

    Find genes that share phenotypes with TOLLIP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tolliptm1Kbns for TOLLIP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TOLLIP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TOLLIP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TOLLIP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TOLLIP

    miRNA
    Products:
        
    miRTarBase miRNAs that target TOLLIP:
    hsa-mir-93-5p (MIRT028044), hsa-mir-130b-3p (MIRT020158), hsa-mir-193b-3p (MIRT041248)

    Block miRNA regulation of human, mouse, rat TOLLIP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TOLLIP (see all 30):
    hsa-miR-548j hsa-miR-548i hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-378b hsa-miR-93 hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidTOLLIP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TOLLIP
    Predesigned siRNA for gene silencing in human, mouse, rat TOLLIP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TOLLIP

    Clone
    Products:
         
    OriGene clones in human, mouse for TOLLIP (see all 6)
    OriGene ORF clones in mouse, rat for TOLLIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TOLLIP (NM_019009)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOLLIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOLLIP

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TOLLIP
    Browse ESI BIO Cell Lines and PureStem Progenitors for TOLLIP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOLLIP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TOLIP_HUMAN, Q9H0E2: Cytoplasm (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    endosome2
    nucleus2
    extracellular1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IC11441107
    GO:0005829cytosol TAS--
    GO:0016604nuclear body IEA--
    GO:0045092interleukin-18 receptor complex NAS10854325
    GO:0045323interleukin-1 receptor complex NAS10854325

    Find genes that share ontologies with TOLLIP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TOLLIP About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    2Immune response Bacterial infections in normal airways
    Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response0.47
    Transcription NF kB signaling pathway0.32
    IL 1 beta dependent CFTR expression0.43
    3Interleukin-1 signaling
    Interleukin-1 signaling0.45
    IL1-mediated signaling events0.45
    4NF-KappaB Family Pathway
    NF-KappaB (p50-p65) Pathway0.72
    NF-KappaB Family Pathway0.72
    5TRAF Pathway
    TRAF Pathway0.42
    Toll-Like Receptors Pathway0.41


    Find genes that share SuperPaths with TOLLIP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TOLLIP
        NF-KappaB (p50-p65) Pathway
    Toll-Like Receptors Pathway
    TRAF Pathway
    IL-1 Pathway
    NF-KappaB Family Pathway

    1 Cell Signaling Technology (CST) Pathway for TOLLIP
        NF-kappaB Signaling

    4 GeneGo (Thomson Reuters) Pathways for TOLLIP
        Transcription NF-kB signaling pathway
    Immune response TLR signaling pathways
    IL-1 beta-dependent CFTR expression
    Immune response IL-1 signaling pathway

    4 BioSystems Pathways for TOLLIP
        Apoptosis Modulation and Signaling
    Toll-like receptor signaling pathway
    IL1-mediated signaling events
    Regulation of toll-like receptor signaling pathway

    1 Reactome Pathway for TOLLIP
        Interleukin-1 signaling


    1 Kegg Pathway  (Kegg details for TOLLIP):
        Toll-like receptor signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TOLLIP (see all 7): 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Huntington's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TOLLIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TOLLIP (Q9H0E21, 3 ENSP000003147334) via UniProtKB, MINT, STRING, and/or I2D (see all 99)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TOM1L1O756741, 3, ENSP000004089584EBI-74615,EBI-712991 I2D: score=4 STRING: ENSP00000408958
    IRAK2O431871, 3, ENSP000002564584EBI-74615,EBI-447733 I2D: score=1 STRING: ENSP00000256458
    PEG10Q86TG71, 3, ENSP000004175874EBI-74615,EBI-2858265 I2D: score=1 STRING: ENSP00000417587
    WRNIP1Q96S551, 3, ENSP000003701504EBI-74615,EBI-2513471 I2D: score=1 STRING: ENSP00000370150
    ENSG00000206379O759553I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response NAS10854325
    GO:0007165signal transduction IPI11441107
    GO:0007267cell-cell signaling TAS10854325
    GO:0016310phosphorylation IDA1085432
    GO:0030855epithelial cell differentiation IEP--

    Find genes that share ontologies with TOLLIP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TOLLIP (TOLIP)

    Selected Novoseek inferred chemical compound relationships for TOLLIP gene (see all 30)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 74.3 79 9678765 (2), 17855441 (2), 9199344 (1), 10026169 (1) (see all 65)
    phosphotyrosine 62.8 7 9482841 (1), 9710592 (1), 9737716 (1), 15737992 (1) (see all 7)
    phosphatidylinositol 3-phosphate 43.9 2 15140579 (1)
    phosphatidylinositol 43.6 9 19330070 (1), 17651088 (1), 7499252 (1), 15202725 (1) (see all 7)
    letrozole 43.3 5 15967659 (1), 17113978 (1), 17611101 (1), 15701882 (1) (see all 5)
    phosphoinositide 37 1 12521378 (1)
    phosphatidylinositol-3,4,5-trisphosphate 36.9 1 16172125 (1)
    ly294002 22.9 1 12621049 (1)
    inositol 22.1 1 9013643 (1)
    threonine 21.7 4 10854325 (1), 17276401 (1), 17625596 (1), 16107720 (1)



    Find genes that share compounds with TOLLIP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TOLLIP gene: 
    NM_019009.3  

    Unigene Cluster for TOLLIP:

    Toll interacting protein
    Hs.368527  [show with all ESTs]
    Unigene Representative Sequence: NM_019009
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000317204(uc001lte.3 uc009ycu.3 uc001ltf.3) ENST00000527886(uc001ltd.3)
    ENST00000525159 ENST00000263646 ENST00000530506 ENST00000527938 ENST00000530541
    ENST00000528719 ENST00000527746 ENST00000527638 ENST00000532551 ENST00000530821
    ENST00000527085 ENST00000542915
    miRNA
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    Block miRNA regulation of human, mouse, rat TOLLIP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TOLLIP (see all 30):
    hsa-miR-548j hsa-miR-548i hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-378b hsa-miR-93 hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidTOLLIP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TOLLIP
    Clone
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    OriGene ORF clones in mouse, rat for TOLLIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TOLLIP (NM_019009)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOLLIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOLLIP
    Primer
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    OriGene qPCR primer pairs and template standards for TOLLIP
    OriGene qSTAR qPCR primer pairs in human, mouse for TOLLIP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TOLLIP
      QuantiTect SYBR Green Assays in human, mouse, rat TOLLIP
      QuantiFast Probe-based Assays in human, mouse, rat TOLLIP

    Additional mRNA sequence: 

    AB209541.1 AJ242972.1 AK022871.1 AK090850.1 AK096693.1 AK127123.1 AK315592.1 AL136835.1 
    AY730683.1 BC004420.1 BC012057.1 BC018272.1 CR533477.1 

    15 DOTS entries:

    DT.120714802  DT.100793245  DT.444846  DT.100809199  DT.100705767  DT.102842608  DT.100793235  DT.100793236 
    DT.100793239  DT.120714755  DT.120714800  DT.75195364  DT.97846496  DT.100793243  DT.120714773 

    Selected AceView cDNA sequences (see all 305):

    AA363771 AW294488 CB148295 BU195369 BU952267 BM794375 BP338109 AI215164 
    BM702224 CF145912 AI480274 BU740722 BM915457 CD243777 BQ961826 AI686617 
    BE047886 BE796029 AK090850 AI278273 BI767420 AA360511 AI078838 BE795865 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TOLLIP (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d · 12e ·
    SP1:                          -     -     -                 -     -     -           -                             -     -     -                                 
    SP2:                                                        -     -     -           -                             -     -     -                                 
    SP3:                          -     -     -     -     -     -     -     -           -                             -     -     -                                 
    SP4:                          -     -     -                 -     -     -     -     -                             -     -     -                                 
    SP5:                          -     -     -     -     -     -     -     -           -                                                                           

    ExUns: 12f
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for TOLLIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TOLLIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGTTCTGGA
    TOLLIP Expression
    About this image


    TOLLIP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    TOLLIP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TOLLIP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.368527
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TOLLIP (see all 7): 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Huntington's Disease in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TOLLIP gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tollip1 , 5 toll interacting protein1, 5 86.08(n)1
    93.04(a)1
      7 (87.34 cM)5
    544731  NM_023764.31  NP_076253.11 
     1418748135 
    chicken
    (Gallus gallus)
    Aves TOLLIP1 toll interacting protein 78.51(n)
    89.38(a)
      423099  NM_001006471.1  NP_001006471.1 
    lizard
    (Anolis carolinensis)
    Reptilia TOLLIP6
    toll interacting protein
    82(a)
    1 ↔ 1
    1(71857794-71896495)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tollip1 toll interacting protein 74.63(n)
    81.72(a)
      448770  NM_001006922.1  NP_001006923.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.88752 Danio rerio mRNA similar to toll interacting protein more 81(n)    BC046009.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0036151 AgaP_AGAP003615 59.21(n)
    52.03(a)
      1274278  XM_562476.3  XP_562476.3 
    worm
    (Caenorhabditis elegans)
    Secernentea F25H2.13
    tli-11
    C2 domain3
    tli-11
    36(a)3
    49.34(n)1
    44.1(a)1
      I(10543147-10544024)3
    1729361  NM_060356.21  NP_492757.21 


    ENSEMBL Gene Tree for TOLLIP (if available)
    TreeFam Gene Tree for TOLLIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TOLLIP (see all 920)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1920638721,2
    C--1295304(+) GGGTCA/GTGTTC 1 -- int10--------
    rs57440391,2
    C,F,H--1295334(-) CCAGGC/ACATTT 1 -- int111Minor allele frequency- A:0.04NA EU NS WA 1008
    rs1420667851,2
    --1295349(+) GAAAAC/GGCACC 1 -- int10--------
    rs1834328391,2
    --1295406(+) CCCACA/GCCCAC 1 -- int10--------
    rs57440381,2
    C,F--1295436(-) GTCCCA/GGGTGC 1 -- int16Minor allele frequency- G:0.13NA EU WA 334
    rs116071361,2
    C,H--1295522(+) TTGACA/GAGTGA 1 -- int11Minor allele frequency- G:0.00NA 2
    rs1454334181,2
    --1295589(+) CTCGGC/GAACAA 1 -- int10--------
    rs57440371,2
    C,F--1295596(-) ACCATG/ATTTGT 1 -- spd18Minor allele frequency- A:0.06NA EU WA 338
    rs1875657371,2
    --1295644(+) TATGGA/GTCATT 1 -- ut310--------
    rs1909560351,2
    --1295689(+) TTTACA/TATCAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TOLLIP (1295598 - 1330892 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TOLLIP (see all 26):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1001632CNV Deletion20482838
    esv1673155CNV Deletion17803354
    esv2743907CNV Deletion23290073
    esv2743878CNV Deletion23290073
    esv2669189CNV Deletion23128226
    esv1056483CNV Deletion17803354
    esv1170595CNV Insertion17803354
    dgv967n71CNV Loss21882294
    nsv469923CNV Loss18288195
    nsv467637CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TOLLIP
    DNA2.0 Custom Variant and Variant Library Synthesis for TOLLIP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606277    OMIM disorders: --


    Find genes that share disorders with TOLLIP           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TOLLIP gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoproliferative syndrome 49.1 3 12242590 (1), 15661030 (1), 12629654 (1)
    x-linked lymphoproliferative syndrome 49 1 16081788 (1)
    necrosis 36.4 16 9620659 (1), 9744859 (1), 10964568 (1), 11784851 (1) (see all 14)
    tumors 30.8 28 15299064 (1), 9620659 (1), 9744859 (1), 10449755 (1) (see all 26)
    myeloid leukemia chronic 19.4 1 19966867 (1)
    breast cancer 9.52 3 17855441 (2), 15322292 (1)
    cancer 0.239 6 16787325 (1), 18620523 (1), 16480678 (1), 18451132 (1) (see all 6)
    nephrotic syndrome 0 1 12217865 (1)
    breast carcinoma 0 1 17218774 (1)
    shock 0 1 18035683 (1)

    Genetic Association Database (GAD): TOLLIP
    Human Genome Epidemiology (HuGE) Navigator: TOLLIP (12 documents)

    Export disorders for TOLLIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TOLLIP gene, integrated from 10 sources (see all 351):
    (articles sorted by number of sources associating them with TOLLIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tollip, a new component of the IL-1R1 pathway, links IRAK to the IL-1 receptor. (PubMed id 10854325)1, 2, 3, 9 Burns K.... Volpe F. (Nat. Cell Biol. 2000)
    2. Negative regulation of Toll-like receptor-mediated signaling by Tollip. (PubMed id 11751856)1, 2, 9 Zhang G. and Ghosh S. (J. Biol. Chem. 2002)
    3. Association of toll-interacting protein gene polymorphisms with atopic dermatitis. (PubMed id 17362526)1, 4, 9 Schimming T.T....Hoffjan S. (BMC Dermatol. 2007)
    4. Recruitment of clathrin onto endosomes by the Tom1-Tollip complex. (PubMed id 16412388)1, 2, 9 Katoh Y.... Nakayama K. (Biochem. Biophys. Res. Commun. 2006)
    5. Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination. (PubMed id 18987746)1, 4, 9 Kimman T.G....Kerkhof M. (PLoS ONE 2008)
    6. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    7. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    8. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    9. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54472 HGNC: 16476 AceView: TOLLIP Ensembl:ENSG00000078902 euGenes: HUgn54472
    ECgene: TOLLIP Kegg: 54472 H-InvDB: TOLLIP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TOLLIP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TOLLIP gene:
    Search GeneIP for patents involving TOLLIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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