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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TOLLIP Gene

protein-coding   GIFtS: 64
GCID: GC11M001295

Toll Interacting Protein

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Toll Interacting Protein1 2
IL-1RAcPIP2
Adapter Protein2
Toll-Interacting Protein2

External Ids:    HGNC: 164761   Entrez Gene: 544722   Ensembl: ENSG000000789027   OMIM: 6062775   UniProtKB: Q9H0E23   

Export aliases for TOLLIP gene to outside databases

Previous GC identifers: GC11M001759 GC11M001558 GC11M001261 GC11M001262 GC11M001252 GC11M001087


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TOLLIP Gene:
This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling
cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1
receptor trafficking and in the turnover of IL1R-associated kinase. (provided by RefSeq, Aug 2011)

GeneCards Summary for TOLLIP Gene: 
TOLLIP (toll interacting protein) is a protein-coding gene. Diseases associated with TOLLIP include cervical squamous cell carcinoma, and nephrotic syndrome, and among its related super-pathways are Immune response TLR signaling pathways and Toll-like receptor signaling pathway. GO annotations related to this gene include kinase binding and signal transducer activity.

UniProtKB/Swiss-Prot: TOLIP_HUMAN, Q9H0E2
Function: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by
microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase
activity

Gene Wiki entry for TOLLIP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TOLLIP gene promoter:
         AhR   Elk-1   STAT1   Sp1   ATF-2   FOXD1   AP-4   ATF   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTOLLIP promoter sequence
   Search SABiosciences Chromatin IP Primers for TOLLIP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOLLIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p

TOLLIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOLLIP gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M001295:  view genomic region     (about GC identifiers)

Start:
1,295,598 bp from pter      End:
1,330,892 bp from pter
Size:
35,295 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TOLIP_HUMAN, Q9H0E2 (See protein sequence)
Recommended Name: Toll-interacting protein  
Size: 274 amino acids; 30282 Da
Subunit: Oligomerizes. Binds to TLR2 and the TLR4-MD2 complex via its C-terminus. Exists as complex with IRAK1 in
unstimulated cells. Upon IL-1 signaling, Tollip binds to the activated IL-1 receptor complex containing IL-1RI,
IL-1RacP and the adapter protein MyD88, where it interacts with the TIR domain of IL-1RacP. MyD88 then triggers
IRAK1 autophosphorylation, which in turn leads to the dissociation of IRAK1 from Tollip and IL-1RAcP. Interacts
with TOM1L2
Subcellular location: Cytoplasm (Probable)
Sequence caution: Sequence=BAB14283.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for TOLLIP:
1WGL (3D)    
Secondary accessions: Q9H9E6 Q9UJ69

Explore the universe of human proteins at neXtProt for TOLLIP: NX_Q9H0E2

Explore proteomics data for TOLLIP at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H0E2

  • TOLLIP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TOLLIP Protein Expression
    REFSEQ proteins: NP_061882.2  
    ENSEMBL proteins: 
     ENSP00000314733   ENSP00000434035   ENSP00000432668   ENSP00000263646   ENSP00000436393  
     ENSP00000432778   ENSP00000434494   ENSP00000437404  
    Reactome Protein details: Q9H0E2
    Human Recombinant Protein Products for TOLLIP: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TOLLIP
    OriGene Protein Over-expression Lysate for TOLLIP
    OriGene MassSpec for TOLLIP 
    OriGene Custom Protein Services for TOLLIP
    GenScript Custom Purified and Recombinant Proteins Services for TOLLIP
    Novus Biologicals TOLLIP Proteins
    Novus Biologicals TOLLIP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for TOLLIP
    Cloud-Clone Corp. Proteins for TOLLIP 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IC11441107
    GO:0005829cytosol TAS--
    GO:0016604nuclear body IEA--
    GO:0045092interleukin-18 receptor complex NAS10854325
    GO:0045323interleukin-1 receptor complex NAS10854325

    TOLLIP for ontologies           About GeneDecksing



    TOLLIP Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TOLLIP
    R&D Systems Antibodies for TOLLIP
    Cell Signaling Technology (CST) Antibodies for TOLLIP 
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    Novus Biologicals TOLLIP Antibodies
    Abcam antibodies for TOLLIP
    Cloud-Clone Corp. Antibodies for TOLLIP 
    ThermoFisher Antibodies for TOLLIP
    LSBio Antibodies in human, mouse, rat for TOLLIP 

    Assay Products for TOLLIP: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TOLLIP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TOLLIP 
    Cloud-Clone Corp. CLIAs for TOLLIP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR003892 CUE
     IPR000008 C2_Ca-dep
     IPR009060 UBA-like

    Graphical View of Domain Structure for InterPro Entry Q9H0E2

    ProtoNet protein and cluster: Q9H0E2

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB003892 Ubiquitin system component Cue


    UniProtKB/Swiss-Prot: TOLIP_HUMAN, Q9H0E2
    Similarity: Belongs to the tollip family
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 CUE domain


    TOLLIP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TOLIP_HUMAN, Q9H0E2
    Function: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by
    microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase
    activity

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity NAS11441107
    GO:0005150interleukin-1, Type I receptor binding IEA--
    GO:0005515protein binding IPI16189514
    GO:0019900kinase binding IPI10854325
    GO:0031624ubiquitin conjugating enzyme binding IEA--
         
    TOLLIP for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TOLLIP:
     Increased HPV18 LCR reporter a  Low eccentricity cells  Synthetic lethal with c-Myc af 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tollip):
     homeostasis/metabolism  immune system 

    TOLLIP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tolliptm1Kbns for TOLLIP

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TOLLIP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TOLLIP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TOLLIP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TOLLIP 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TOLLIP
    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate TOLLIP (see all 30):
    hsa-miR-548j hsa-miR-548i hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-378b hsa-miR-93 hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidTOLLIP 3' UTR sequence
    Inhib. RNA
    Products:
        
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOLLIP

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for TOLLIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TOLLIP (NM_019009)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOLLIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOLLIP
    Sirion Biotech Customized lentivirus for stable overexpression of TOLLIP 
                         Customized lentivirus expression plasmids for stable overexpression of TOLLIP 

    Cell Line
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    Search LifeMap BioReagents cell lines for TOLLIP
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOLLIP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TOLLIP About   (see all 13)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response0.94
    Immune response TLR signaling pathways0.94
    2Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.93
    3Interleukin-1 signaling
    IL1-mediated signaling events0.39
    Interleukin-1 signaling0.39
    4Toll Comparative Pathway
    Immune response IL-1 signaling pathway0.41
    IL-1 Pathway0.39
    5NF-KappaB Family Pathway
    NF-KappaB Family Pathway0.72
    NF-KappaB (p50-p65) Pathway0.72

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for TOLLIP
        Transcription NF-kB signaling pathway
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response IL-1 signaling pathway

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TOLLIP
        NF-KappaB (p50-p65) Pathway
    Toll-Like Receptors Pathway
    TRAF Pathway
    IL-1 Pathway
    NF-KappaB Family Pathway

    1 Cell Signaling Technology (CST) Pathway for TOLLIP
        NF-kappaB Signaling

    4 GeneGo (Thomson Reuters) Pathways for TOLLIP
        Transcription NF-kB signaling pathway
    Immune response TLR signaling pathways
    IL-1 beta-dependent CFTR expression
    Immune response IL-1 signaling pathway

    3 BioSystems Pathways for TOLLIP
        Apoptosis Modulation and Signaling
    Toll-like receptor signaling pathway
    IL1-mediated signaling events

    4        Reactome Pathways for TOLLIP
        Interleukin-1 signaling
    Cytokine Signaling in Immune system
    Signaling by Interleukins
    Immune System


    1         Kegg Pathway  (Kegg details for TOLLIP):
        Toll-like receptor signaling pathway


    TOLLIP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TOLLIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/99 Interacting proteins for TOLLIP (Q9H0E21, 3 ENSP000003147334) via UniProtKB, MINT, STRING, and/or I2D (see all 99)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TOM1L1O756741, 3, ENSP000004089584EBI-74615,EBI-712991 I2D: score=4 STRING: ENSP00000408958
    IRAK2O431871, 3, ENSP000002564584EBI-74615,EBI-447733 I2D: score=1 STRING: ENSP00000256458
    PEG10Q86TG71, 3, ENSP000004175874EBI-74615,EBI-2858265 I2D: score=1 STRING: ENSP00000417587
    WRNIP1Q96S551, 3, ENSP000003701504EBI-74615,EBI-2513471 I2D: score=1 STRING: ENSP00000370150
    ENSG00000206379O759553I2D: score=2 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response NAS10854325
    GO:0007165signal transduction IPI11441107
    GO:0007267cell-cell signaling TAS10854325
    GO:0016310phosphorylation IDA1085432
    GO:0033235positive regulation of protein sumoylation IEA--

    TOLLIP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TOLLIP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TOLLIP (TOLIP)

    10/30 Novoseek inferred chemical compound relationships for TOLLIP gene (see all 30)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 74.3 79 9678765 (2), 17855441 (2), 9199344 (1), 10026169 (1) (see all 65)
    phosphotyrosine 62.8 7 9482841 (1), 9710592 (1), 9737716 (1), 15737992 (1) (see all 7)
    phosphatidylinositol 3-phosphate 43.9 2 15140579 (1)
    phosphatidylinositol 43.6 9 19330070 (1), 17651088 (1), 7499252 (1), 15202725 (1) (see all 7)
    letrozole 43.3 5 15967659 (1), 17113978 (1), 17611101 (1), 15701882 (1) (see all 5)
    phosphoinositide 37 1 12521378 (1)
    phosphatidylinositol-3,4,5-trisphosphate 36.9 1 16172125 (1)
    ly294002 22.9 1 12621049 (1)
    inositol 22.1 1 9013643 (1)
    threonine 21.7 4 10854325 (1), 17276401 (1), 17625596 (1), 16107720 (1)

    Search CenterWatch for drugs/clinical trials and news about TOLLIP / TOLIP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TOLLIP gene: 
    NM_019009.3  

    Unigene Cluster for TOLLIP:

    Toll interacting protein
    Hs.368527  [show with all ESTs]
    Unigene Representative Sequence: NM_019009
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000317204(uc001lte.3 uc009ycu.3 uc001ltf.3) ENST00000527886(uc001ltd.3)
    ENST00000525159 ENST00000263646 ENST00000530506 ENST00000527938 ENST00000530541
    ENST00000528719 ENST00000527746 ENST00000527638 ENST00000532551 ENST00000530821
    ENST00000527085 ENST00000542915
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate TOLLIP (see all 30):
    hsa-miR-548j hsa-miR-548i hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-378b hsa-miR-93 hsa-miR-548d-5p
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    GenScript: all cDNA clones in your preferred vector: TOLLIP (NM_019009)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOLLIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOLLIP
    Sirion Biotech Customized lentivirus for stable overexpression of TOLLIP 
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    OriGene qPCR primer pairs and template standards for TOLLIP
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOLLIP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOLLIP

    Additional mRNA sequence: 

    AB209541.1 AJ242972.1 AK022871.1 AK090850.1 AK096693.1 AK127123.1 AK315592.1 AL136835.1 
    AY730683.1 BC004420.1 BC012057.1 BC018272.1 CR533477.1 

    15 DOTS entries:

    DT.120714802  DT.100793245  DT.444846  DT.100809199  DT.100705767  DT.102842608  DT.100793235  DT.100793236 
    DT.100793239  DT.120714755  DT.120714800  DT.75195364  DT.97846496  DT.100793243  DT.120714773 

    24/305 AceView cDNA sequences (see all 305):

    CA395299 BI767420 BU740722 BM069752 BE047886 AW294495 BE796029 AA363771 
    BU155728 AK090850 AW068487 CD243777 D62608 BX366329 BM702224 BI825192 
    BC004420 BM699139 BI766918 BI753044 BI753357 AI126693 AL136835 BX441711 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for TOLLIP (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d · 12e ·
    SP1:                          -     -     -                 -     -     -           -                             -     -     -                                 
    SP2:                                                        -     -     -           -                             -     -     -                                 
    SP3:                          -     -     -     -     -     -     -     -           -                             -     -     -                                 
    SP4:                          -     -     -                 -     -     -     -     -                             -     -     -                                 
    SP5:                          -     -     -     -     -     -     -     -           -                                                                           

    ExUns: 12f
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for TOLLIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TOLLIP expression in normal human tissues (normalized intensities)      TOLLIP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGTTCTGGA
    TOLLIP Expression
    About this image


    TOLLIP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             postcentral gyrus   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             testis ; cells in seminiferus ducts   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   

    See TOLLIP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TOLLIP

    SOURCE GeneReport for Unigene cluster: Hs.368527
        SABiosciences Expression via Pathway-Focused PCR Arrays including TOLLIP (see all 7): 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              PI3K-AKT Signaling Pathway in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Huntington's Disease in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TOLLIP gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tollip1 , 5 toll interacting protein1, 5 86.08(n)1
    93.04(a)1
      7 (87.34 cM)5
    544731  NM_023764.31  NP_076253.11 
     1418748135 
    chicken
    (Gallus gallus)
    Aves TOLLIP1 toll interacting protein 78.51(n)
    89.38(a)
      423099  NM_001006471.1  NP_001006471.1 
    lizard
    (Anolis carolinensis)
    Reptilia TOLLIP6
    Uncharacterized protein
    82(a)
    1 ↔ 1
    1(71857794-71896495)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.88752 Danio rerio mRNA similar to toll interacting protein more 81(n)    BC046009.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0036151 AGAP003615-PA 59.45(n)
    52.07(a)
      1274278  XM_562476.2  XP_562476.2 
    worm
    (Caenorhabditis elegans)
    Secernentea F25H2.13
    tli-11
    C2 domain3
    Protein TLI-11
    36(a)3
    49.64(n)1
    44.1(a)1
      I(10543147-10544024)3
    1729361  NM_060356.21  NP_492757.21 


    ENSEMBL Gene Tree for TOLLIP (if available)
    TreeFam Gene Tree for TOLLIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/920 SNPs in TOLLIP are shown (see all 920)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1920638721,2
    C--1295304(+) GGGTCA/GTGTTC 1 -- int10--------
    rs57440391,2
    C,F,H--1295334(-) CCAGGC/ACATTT 1 -- int111Minor allele frequency- A:0.04NA EU NS WA 1008
    rs1420667851,2
    --1295349(+) GAAAAC/GGCACC 1 -- int10--------
    rs1834328391,2
    --1295406(+) CCCACA/GCCCAC 1 -- int10--------
    rs57440381,2
    C,F--1295436(-) GTCCCA/GGGTGC 1 -- int16Minor allele frequency- G:0.13NA EU WA 334
    rs116071361,2
    C,H--1295522(+) TTGACA/GAGTGA 1 -- int11Minor allele frequency- G:0.00NA 2
    rs1454334181,2
    --1295589(+) CTCGGC/GAACAA 1 -- int10--------
    rs57440371,2
    C,F--1295596(-) ACCATG/ATTTGT 1 -- spd18Minor allele frequency- A:0.06NA EU WA 338
    rs1875657371,2
    --1295644(+) TATGGA/GTCATT 1 -- ut310--------
    rs1909560351,2
    --1295689(+) TTTACA/TATCAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TOLLIP (1295598 - 1330892 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/26 variations for TOLLIP (see all 26):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1001632CNV Deletion20482838
    esv1673155CNV Deletion17803354
    esv2743907CNV Deletion23290073
    esv2743878CNV Deletion23290073
    esv2669189CNV Deletion23128226
    esv1056483CNV Deletion17803354
    esv1170595CNV Insertion17803354
    dgv967n71CNV Loss21882294
    nsv469923CNV Loss18288195
    nsv467637CNV Loss19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606277    OMIM disorders: --

    20/24 diseases for TOLLIP (see all 24):    About MalaCards
    cervical squamous cell carcinoma    nephrotic syndrome    pertussis    atopic dermatitis
    down syndrome    dermatitis    huntington's disease    meningioma
    inflammatory bowel disease    chronic lymphocytic leukemia    melanoma    alcoholism
    squamous cell carcinoma    adenoma    cervicitis    hepatitis b
    endotheliitis    myeloid leukemia    leukemia    breast cancer


    TOLLIP for disorders           About GeneDecksing

    10/16 Novoseek inferred disease relationships for TOLLIP gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoproliferative syndrome 49.1 3 12242590 (1), 15661030 (1), 12629654 (1)
    x-linked lymphoproliferative syndrome 49 1 16081788 (1)
    necrosis 36.4 16 9620659 (1), 9744859 (1), 10964568 (1), 11784851 (1) (see all 14)
    tumors 30.8 28 15299064 (1), 9620659 (1), 9744859 (1), 10449755 (1) (see all 26)
    myeloid leukemia chronic 19.4 1 19966867 (1)
    breast cancer 9.52 3 17855441 (2), 15322292 (1)
    cancer 0.239 6 16787325 (1), 18620523 (1), 16480678 (1), 18451132 (1) (see all 6)
    nephrotic syndrome 0 1 12217865 (1)
    breast carcinoma 0 1 17218774 (1)
    shock 0 1 18035683 (1)

    Genetic Association Database (GAD): TOLLIP
    Human Genome Epidemiology (HuGE) Navigator: TOLLIP (12 documents)

    Export disorders for TOLLIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TOLLIP gene, integrated from 9 sources (see all 348):
    (articles sorted by number of sources associating them with TOLLIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tollip, a new component of the IL-1R1 pathway, links IRAK to the IL-1 receptor. (PubMed id 10854325)1, 2, 3, 9 Burns K.... Volpe F. (2000)
    2. Negative regulation of Toll-like receptor-mediated signaling by Tollip. (PubMed id 11751856)1, 2, 9 Zhang G. and Ghosh S. (2002)
    3. Association of toll-interacting protein gene polymorphisms with atopic dermatitis. (PubMed id 17362526)1, 4, 9 Schimming T.T....Hoffjan S. (2007)
    4. Recruitment of clathrin onto endosomes by the Tom1-Tollip complex. (PubMed id 16412388)1, 2, 9 Katoh Y.... Nakayama K. (2006)
    5. Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination. (PubMed id 18987746)1, 4, 9 Kimman T.G....Kerkhof M. (2008)
    6. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    7. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    8. Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (2010)
    9. Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (2010)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54472 HGNC: 16476 AceView: TOLLIP Ensembl:ENSG00000078902 euGenes: HUgn54472
    ECgene: TOLLIP Kegg: 54472 H-InvDB: TOLLIP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TOLLIP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TOLLIP gene:
    Search GeneIP for patents involving TOLLIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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