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Aliases for TOGARAM2 Gene

Aliases for TOGARAM2 Gene

  • TOG Array Regulator Of Axonemal Microtubules 2 2 3 5
  • Family With Sequence Similarity 179 Member A 2 3
  • FAM179A 3 4
  • TOG Array Regulator Of Axonemal Microtubules Protein 2 3
  • Family With Sequence Similarity 179, Member A 2
  • Protein FAM179A 3
  • Crescerin 2 2
  • Crescerin-2 3

External Ids for TOGARAM2 Gene

Previous HGNC Symbols for TOGARAM2 Gene

  • FAM179A

Summaries for TOGARAM2 Gene

GeneCards Summary for TOGARAM2 Gene

TOGARAM2 (TOG Array Regulator Of Axonemal Microtubules 2) is a Protein Coding gene. An important paralog of this gene is TOGARAM1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOGARAM2 Gene

Genomics for TOGARAM2 Gene

Regulatory Elements for TOGARAM2 Gene

Enhancers for TOGARAM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G028747 2 FANTOM5 Ensembl ENCODE dbSUPER 18.8 -204.5 -204466 9.3 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 TRMT61B TOGARAM2 PPP1CB SPDYA ENSG00000230730 WDR43 FOSL2 LOC100505774
GH02G029008 1.3 Ensembl ENCODE dbSUPER 28.3 +57.0 56974 9.8 CTCF MAX EBF1 ZIC2 THRB RAD21 ZBTB40 ZKSCAN1 ZFHX2 GATA3 TOGARAM2 C2orf71 PPP1CB TRMT61B ENSG00000200283 LOC105374385
GH02G028893 1.1 ENCODE 30.8 -61.0 -61036 3.3 PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 TOGARAM2 WDR43 TRMT61B GC02P028913
GH02G028999 1.3 Ensembl ENCODE dbSUPER 23.1 +44.6 44572 3.2 CTCF USF1 ZMYM3 MAX CEBPG RAD21 ZIC2 ZNF335 EED SCRT2 TOGARAM2 PPP1CB ENSG00000200283 LOC105374385
GH02G028950 1.5 FANTOM5 Ensembl ENCODE 19.9 -4.7 -4713 3.0 FOXA2 DMAP1 RAD21 RARA YY1 TCF12 THAP11 MXD4 CEBPB REST TOGARAM2 TRMT61B WDR43 PPP1CB ENSG00000265706
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TOGARAM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TOGARAM2 Gene

Chromosome:
2
Start:
28,956,611 bp from pter
End:
29,061,373 bp from pter
Size:
104,763 bases
Orientation:
Plus strand

Genomic View for TOGARAM2 Gene

Genes around TOGARAM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOGARAM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOGARAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOGARAM2 Gene

Proteins for TOGARAM2 Gene

  • Protein details for TOGARAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZUX3-CREC2_HUMAN
    Recommended name:
    Crescerin-2
    Protein Accession:
    Q6ZUX3
    Secondary Accessions:
    • Q6ZUF5

    Protein attributes for TOGARAM2 Gene

    Size:
    1019 amino acids
    Molecular mass:
    111153 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TOGARAM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TOGARAM2 Gene

Post-translational modifications for TOGARAM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TOGARAM2 Gene

Domains & Families for TOGARAM2 Gene

Protein Domains for TOGARAM2 Gene

Suggested Antigen Peptide Sequences for TOGARAM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZUX3

UniProtKB/Swiss-Prot:

CREC2_HUMAN :
  • Belongs to the Crescerin family.
Family:
  • Belongs to the Crescerin family.
genes like me logo Genes that share domains with TOGARAM2: view

No data available for Gene Families for TOGARAM2 Gene

Function for TOGARAM2 Gene

Phenotypes for TOGARAM2 Gene

genes like me logo Genes that share phenotypes with TOGARAM2: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TOGARAM2 Gene

Localization for TOGARAM2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TOGARAM2 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TOGARAM2 Gene

Pathways & Interactions for TOGARAM2 Gene

SuperPathways for TOGARAM2 Gene

No Data Available

Interacting Proteins for TOGARAM2 Gene

Gene Ontology (GO) - Biological Process for TOGARAM2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TOGARAM2 Gene

Drugs & Compounds for TOGARAM2 Gene

No Compound Related Data Available

Transcripts for TOGARAM2 Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOGARAM2 Gene

No ASD Table

Relevant External Links for TOGARAM2 Gene

GeneLoc Exon Structure for
TOGARAM2
ECgene alternative splicing isoforms for
TOGARAM2

Expression for TOGARAM2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TOGARAM2 Gene:

TOGARAM2
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TOGARAM2 Gene

Orthologs for TOGARAM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TOGARAM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM179A 35 34
  • 98.66 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM179A 35 34
  • 83.19 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAM179A 35 34
  • 83.06 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam179a 34
  • 78.92 (n)
mouse
(Mus musculus)
Mammalia Fam179a 16 35 34
  • 78.74 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM179A 35
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM179A 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM179A 35 34
  • 61.12 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM179A 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam179a 34
  • 54.11 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG42399 35
  • 7 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea che-12 35
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 22 (a)
OneToMany
Species where no ortholog for TOGARAM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TOGARAM2 Gene

ENSEMBL:
Gene Tree for TOGARAM2 (if available)
TreeFam:
Gene Tree for TOGARAM2 (if available)

Paralogs for TOGARAM2 Gene

Paralogs for TOGARAM2 Gene

genes like me logo Genes that share paralogs with TOGARAM2: view

Variants for TOGARAM2 Gene

Sequence variations from dbSNP and Humsavar for TOGARAM2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000060434 -- 29,047,990(+) CTGTA(A/T)TAGCC intron-variant
rs1000109408 -- 29,025,309(+) CGAAA(C/G)CGCAC intron-variant
rs1000168627 -- 29,021,311(+) AAGCT(C/T)GGGAG intron-variant
rs1000171842 -- 28,989,769(+) AAGCG(A/G)TCAGA intron-variant
rs1000187873 -- 28,982,638(+) GTCAA(C/T)CTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TOGARAM2 Gene

Variant ID Type Subtype PubMed ID
dgv2088e59 CNV duplication 20981092
dgv213n21 CNV loss 19592680
dgv592e201 CNV deletion 23290073
dgv686e199 CNV deletion 23128226
dgv687e199 CNV deletion 23128226
dgv688e199 CNV deletion 23128226
esv1152713 CNV deletion 17803354
esv2162111 CNV deletion 18987734
esv2660458 CNV deletion 23128226
esv2670234 CNV deletion 23128226
esv2719845 CNV deletion 23290073
esv2719846 CNV deletion 23290073
esv2719847 CNV deletion 23290073
esv2719849 CNV deletion 23290073
esv2719852 CNV deletion 23290073
esv2719853 CNV deletion 23290073
esv2719854 CNV deletion 23290073
esv2719855 CNV deletion 23290073
esv2759035 CNV gain 17122850
esv2762437 CNV loss 21179565
esv34904 CNV gain 17911159
esv3583692 CNV loss 25503493
esv3583695 CNV loss 25503493
esv3583696 CNV loss 25503493
esv3590167 CNV gain 21293372
esv3590168 CNV loss 21293372
esv4275 CNV loss 18987735
esv7077 CNV loss 19470904
nsv1008490 CNV gain 25217958
nsv1072401 CNV deletion 25765185
nsv1134845 CNV deletion 24896259
nsv1138761 CNV deletion 24896259
nsv1151130 CNV duplication 26484159
nsv2657 CNV deletion 18451855
nsv525642 CNV gain 19592680
nsv528652 CNV gain 19592680
nsv581247 CNV loss 21841781

Variation tolerance for TOGARAM2 Gene

Residual Variation Intolerance Score: 99.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.30; 99.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TOGARAM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TOGARAM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOGARAM2 Gene

Disorders for TOGARAM2 Gene

Relevant External Links for TOGARAM2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TOGARAM2

No disorders were found for TOGARAM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TOGARAM2 Gene

Publications for TOGARAM2 Gene

  1. Crescerin uses a TOG domain array to regulate microtubules in the primary cilium. (PMID: 26378256) Das A. … Slep K.C. (Mol. Biol. Cell 2015) 2 3 64
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 2 3 64
  3. Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9. (PMID: 24376456) Simino J. … Rao D.C. (Front Genet 2013) 3 64
  4. Genome-wide association study of recurrent early-onset major depressive disorder. (PMID: 20125088) Shi J. … Levinson D.F. (Mol. Psychiatry 2011) 3 64
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64

Products for TOGARAM2 Gene

Sources for TOGARAM2 Gene

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