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Aliases for TOGARAM1 Gene

Aliases for TOGARAM1 Gene

  • TOG Array Regulator Of Axonemal Microtubules 1 2 3 5
  • KIAA0423 2 3 4
  • Family With Sequence Similarity 179 Member B 2 3
  • Protein FAM179B 3 4
  • Crescerin 2 3
  • TOG Array Regulator Of Axonemal Microtubules Protein 1 3
  • Family With Sequence Similarity 179, Member B 2
  • Crescerin-1 3
  • FAM179B 3

External Ids for TOGARAM1 Gene

Previous HGNC Symbols for TOGARAM1 Gene

  • KIAA0423
  • FAM179B

Summaries for TOGARAM1 Gene

GeneCards Summary for TOGARAM1 Gene

TOGARAM1 (TOG Array Regulator Of Axonemal Microtubules 1) is a Protein Coding gene. An important paralog of this gene is TOGARAM2.

UniProtKB/Swiss-Prot for TOGARAM1 Gene

  • Required for normal structure and function of primary cilia. Plays a role in the organization of axoneme microtubule bundles in primary cilia (By similarity). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4 (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOGARAM1 Gene

Genomics for TOGARAM1 Gene

Regulatory Elements for TOGARAM1 Gene

Enhancers for TOGARAM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G045138 0.4 FANTOM5 10.4 +176.3 176265 0.4 PRDM1 ENSG00000212615 PRPF39 LOC105370474 KLHL28 TOGARAM1 SNORD127 FANCM GC14M044793
GH14G045139 0.2 Ensembl 10.4 +176.7 176693 0.2 LOC105370474 ENSG00000212615 PRPF39 KLHL28 TOGARAM1 SNORD127 FANCM GC14M044793
GH14G044959 1.1 ENCODE 0.7 -0.3 -299 4.8 HDGF PKNOX1 FOXA2 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZBTB7B TOGARAM1 GC14M044938
GH14G044944 0.2 ENCODE 0.4 -16.7 -16731 1.0 C14orf28 SNORD127 GC14M044938 TOGARAM1
GH14G044940 0.2 ENCODE 0.3 -21.2 -21221 0.8 C14orf28 SNORD127 GC14M044938 TOGARAM1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TOGARAM1 on UCSC Golden Path with GeneCards custom track

Promoters for TOGARAM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000067969 -208 3601 HDGF PKNOX1 FOXA2 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZBTB7B

Genomic Location for TOGARAM1 Gene

Chromosome:
14
Start:
44,962,208 bp from pter
End:
45,074,431 bp from pter
Size:
112,224 bases
Orientation:
Plus strand

Genomic View for TOGARAM1 Gene

Genes around TOGARAM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOGARAM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOGARAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOGARAM1 Gene

Proteins for TOGARAM1 Gene

  • Protein details for TOGARAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4F4-CREC1_HUMAN
    Recommended name:
    Crescerin-1
    Protein Accession:
    Q9Y4F4
    Secondary Accessions:
    • Q68D66
    • Q6PG27

    Protein attributes for TOGARAM1 Gene

    Size:
    1720 amino acids
    Molecular mass:
    189360 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA24853.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH18354.1; Type=Frameshift; Positions=1069, 1506; Evidence={ECO:0000305};

    Alternative splice isoforms for TOGARAM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TOGARAM1 Gene

Post-translational modifications for TOGARAM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TOGARAM1 Gene

Domains & Families for TOGARAM1 Gene

Protein Domains for TOGARAM1 Gene

Suggested Antigen Peptide Sequences for TOGARAM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y4F4

UniProtKB/Swiss-Prot:

CREC1_HUMAN :
  • The TOG regions are composed of HEAT-type repeats that assemble into a solenoid structure. They mediate interaction with microtubules.
  • Belongs to the Crescerin family.
Domain:
  • The TOG regions are composed of HEAT-type repeats that assemble into a solenoid structure. They mediate interaction with microtubules.
Family:
  • Belongs to the Crescerin family.
genes like me logo Genes that share domains with TOGARAM1: view

No data available for Gene Families for TOGARAM1 Gene

Function for TOGARAM1 Gene

Molecular function for TOGARAM1 Gene

UniProtKB/Swiss-Prot Function:
Required for normal structure and function of primary cilia. Plays a role in the organization of axoneme microtubule bundles in primary cilia (By similarity). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4 (By similarity).
genes like me logo Genes that share phenotypes with TOGARAM1: view

Animal Model Products

miRNA for TOGARAM1 Gene

miRTarBase miRNAs that target TOGARAM1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TOGARAM1 Gene

Localization for TOGARAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOGARAM1 Gene

Cell projection, cilium. Cytoplasm, cytoskeleton. Note=Detected along the length of primary cilia and at the basal body. Colocalization with the cytoplasmic microtubule cytoskeleton upon heterologous expression is most likely an artifact. {ECO:0000250 UniProtKB:Q6A070}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TOGARAM1 gene
Compartment Confidence
cytoskeleton 4
nucleus 2
endoplasmic reticulum 2
extracellular 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TOGARAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 colocalizes_with microtubule IEA,ISS --
GO:0005929 cilium ISS,IEA --
GO:0036064 ciliary basal body ISS,IEA --
genes like me logo Genes that share ontologies with TOGARAM1: view

Pathways & Interactions for TOGARAM1 Gene

SuperPathways for TOGARAM1 Gene

No Data Available

Interacting Proteins for TOGARAM1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000355045%0d%0a9606.ENSP00000377262%0d%0a
Selected Interacting proteins: Q9Y4F4-CREC1_HUMAN ENSP00000355045 for TOGARAM1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for TOGARAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030030 cell projection organization IEA --
GO:0031116 positive regulation of microtubule polymerization IEA,ISS --
GO:0035082 axoneme assembly ISS --
GO:1905515 non-motile cilium assembly ISS --
genes like me logo Genes that share ontologies with TOGARAM1: view

No data available for Pathways by source and SIGNOR curated interactions for TOGARAM1 Gene

Transcripts for TOGARAM1 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOGARAM1 Gene

No ASD Table

Relevant External Links for TOGARAM1 Gene

GeneLoc Exon Structure for
TOGARAM1
ECgene alternative splicing isoforms for
TOGARAM1

Expression for TOGARAM1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TOGARAM1 Gene:

TOGARAM1

Evidence on tissue expression from TISSUES for TOGARAM1 Gene

  • Nervous system(4.4)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TOGARAM1 Gene

Orthologs for TOGARAM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TOGARAM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM179B 35 34
  • 99.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAM179B 35 34
  • 91.17 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM179B 35 34
  • 90.52 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam179b 34
  • 87.19 (n)
mouse
(Mus musculus)
Mammalia Fam179b 35 16 34
  • 86.32 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM179B 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM179B 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM179B 34
  • 67.68 (n)
lizard
(Anolis carolinensis)
Reptilia FAM179B 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495084 34
  • 56.62 (n)
zebrafish
(Danio rerio)
Actinopterygii FAM179B 35
  • 30 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42399 35
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea che-12 35
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 27 (a)
OneToMany
Species where no ortholog for TOGARAM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TOGARAM1 Gene

ENSEMBL:
Gene Tree for TOGARAM1 (if available)
TreeFam:
Gene Tree for TOGARAM1 (if available)

Paralogs for TOGARAM1 Gene

Paralogs for TOGARAM1 Gene

genes like me logo Genes that share paralogs with TOGARAM1: view

Variants for TOGARAM1 Gene

Sequence variations from dbSNP and Humsavar for TOGARAM1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000019977 -- 45,003,275(+) TAGGT(A/T)TTTTG intron-variant
rs1000030748 -- 45,053,558(+) GAATA(A/G)TATTA intron-variant
rs1000047015 -- 45,074,422(+) GGATT(G/T)ATTTC nc-transcript-variant, utr-variant-3-prime
rs1000062060 -- 45,022,305(+) CTACC(A/G)AAACT intron-variant
rs1000078024 -- 44,966,611(+) CTAAA(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TOGARAM1 Gene

Variant ID Type Subtype PubMed ID
dgv1904n100 CNV loss 25217958
esv2505295 CNV deletion 19546169
esv2748675 CNV deletion 23290073
esv3634341 CNV loss 21293372
nsv1038384 CNV loss 25217958
nsv1127379 CNV deletion 24896259
nsv1259 CNV deletion 18451855
nsv1260 CNV deletion 18451855
nsv832785 CNV loss 17160897

Variation tolerance for TOGARAM1 Gene

Residual Variation Intolerance Score: 5.41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.85; 83.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TOGARAM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TOGARAM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOGARAM1 Gene

Disorders for TOGARAM1 Gene

Relevant External Links for TOGARAM1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TOGARAM1

No disorders were found for TOGARAM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TOGARAM1 Gene

Publications for TOGARAM1 Gene

  1. Crescerin uses a TOG domain array to regulate microtubules in the primary cilium. (PMID: 26378256) Das A. … Slep K.C. (Mol. Biol. Cell 2015) 2 3 64
  2. Detection of hypothetical proteins in human fetal perireticular nucleus. (PMID: 16335990) Hepner F. … Lubec G. (J. Proteome Res. 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 3 4 64

Products for TOGARAM1 Gene

Sources for TOGARAM1 Gene

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