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TOE1 Gene

protein-coding   GIFtS: 51
GCID: GC01P045805

Target Of EGR1, Member 1 (Nuclear)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Target Of EGR1, Member 1 (Nuclear)1 2
Target Of EGR1 Protein 12

External Ids:    HGNC: 159541   Entrez Gene: 1140342   Ensembl: ENSG000001327737   OMIM: 6139315   UniProtKB: Q96GM83   

Export aliases for TOE1 gene to outside databases

Previous GC identifers: GC00U991071 GC01P045235 GC01P045218 GC01P045474 GC01P045577 GC01P043916


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TOE1 Gene:
TOE1 (target of EGR1, member 1 (nuclear)) is a protein-coding gene. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot: TOE1_HUMAN, Q96GM8
Function: Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression.
Mediates the inhibitory growth effect of EGR1

Gene Wiki entry for TOE1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TOE1 gene promoter:
         E2F-3a   E2F-4   STAT1   E2F-5   E2F-2   Evi-1   HEN1   E2F   E2F-1   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TOE1 promoter sequence
   Search Chromatin IP Primers for TOE1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TOE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p33

TOE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOE1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P045805:  view genomic region     (about GC identifiers)

Start:
45,805,342 bp from pter      End:
45,809,650 bp from pter
Size:
4,309 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TOE1_HUMAN, Q96GM8 (See protein sequence)
Recommended Name: Target of EGR1 protein 1  
Size: 510 amino acids; 56548 Da
1 PDB 3D structure from and Proteopedia for TOE1:
2FC6 (3D)    
Secondary accessions: Q6IA35 Q8IWN5 Q9H846

Explore the universe of human proteins at neXtProt for TOE1: NX_Q96GM8

Explore proteomics data for TOE1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TOE1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079353.3  
    ENSEMBL proteins: 
     ENSP00000361162   ENSP00000438900  

    TOE1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TOE1

     
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    Search eBioscience for ELISAs for TOE1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR000571 Znf_CCCH
     IPR006941 RNase_CAF1
     IPR012337 RNaseH-like_dom

    Graphical View of Domain Structure for InterPro Entry Q96GM8

    ProtoNet protein and cluster: Q96GM8

    1 Blocks protein domain: IPB000571 Zn-finger

    UniProtKB/Swiss-Prot: TOE1_HUMAN, Q96GM8
    Similarity: Belongs to the CAF1 family
    Similarity: Contains 1 C3H1-type zinc finger


    Find genes that share domains with TOE1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TOE1_HUMAN, Q96GM8
    Function: Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression.
    Mediates the inhibitory growth effect of EGR1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0005515protein binding IPI19508870
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with TOE1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TOE1:
     Increased HPV18 LCR reporter a  Low eccentricity cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TOE1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TOE1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TOE1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TOE1:
    hsa-let-7b-5p (MIRT032323), hsa-mir-320a (MIRT044528)

    Block miRNA regulation of human, mouse, rat TOE1 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate TOE1:
    hsa-miR-3671 hsa-miR-548a-3p hsa-miR-129-5p hsa-miR-1267 hsa-miR-548e hsa-miR-552
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TOE1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: TOE1 (NM_025077)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOE1

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    Browse ESI BIO Cell Lines and PureStem Progenitors for TOE1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOE1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TOE1_HUMAN, Q96GM8: Nucleus, nucleolus. Nucleus speckle. Note=Localizes to nuclear speckles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IEA--
    GO:0016607nuclear speck IEA--

    Find genes that share ontologies with TOE1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TOE1
    Interactions:

        Search GeneGlobe Interaction Network for TOE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for TOE1 (Q96GM81, 2, 3 ENSP000003611624) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046371, 2, 3, ENSP000002693054EBI-717460,EBI-366083 MINT-7144884 MINT-7144912 MINT-7144895 I2D: score=1 STRING: ENSP00000269305
    ABCF3Q9NUQ82, 3MINT-65158 I2D: score=5 
    APLP1P516932, 3MINT-64599 I2D: score=5 
    SH3GL3Q999632, 3MINT-64605 I2D: score=5 
    SUMO1P631652, 3MINT-64601 I2D: score=5 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TOE1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TOE1 gene: 
    NM_025077.3  

    Unigene Cluster for TOE1:

    Target of EGR1, member 1 (nuclear)
    Hs.525091  [show with all ESTs]
    Unigene Representative Sequence: NM_025077
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372090(uc009vxq.3 uc010olm.2) ENST00000477731 ENST00000471337
    ENST00000495703(uc010oln.1 uc001cnr.4) ENST00000460057 ENST00000539779

    miRNA
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    Block miRNA regulation of human, mouse, rat TOE1 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate TOE1:
    hsa-miR-3671 hsa-miR-548a-3p hsa-miR-129-5p hsa-miR-1267 hsa-miR-548e hsa-miR-552
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TOE1
    Clone
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    OriGene clones in human, mouse for TOE1 (see all 6)
    OriGene ORF clones in mouse, rat for TOE1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TOE1 (NM_025077)
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    Primer
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    OriGene qPCR primer pairs and template standards for TOE1
    OriGene qSTAR qPCR primer pairs in human, mouse for TOE1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TOE1
      QuantiTect SYBR Green Assays in human, mouse, rat TOE1
      QuantiFast Probe-based Assays in human, mouse, rat TOE1

    Additional mRNA sequence: 

    AK024011.1 AK293704.1 AK298162.1 AY169960.1 BC009364.2 CR457320.1 

    18 DOTS entries:

    DT.100708959  DT.416232  DT.97854702  DT.100663193  DT.99937199  DT.412280  DT.95178812  DT.97798730 
    DT.100765377  DT.121426007  DT.92443341  DT.100663185  DT.92059999  DT.121425936  DT.121425745  DT.92443342 
    DT.100870054  DT.95088446 

    Selected AceView cDNA sequences (see all 186):

    BI324947 BX395622 CD369976 AU142883 CR598664 AI475471 AI745510 BE618211 
    BG257276 AI339149 AI187709 CR591540 BI253196 BU618393 AA766200 BM457200 
    CA422070 BM711367 BC009364 BM664633 CR608938 CR616202 AI590068 BG055810 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TOE1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9 ^ 10
    SP1:                                -     -     -                       -                 -                                                         
    SP2:                                      -     -                       -                 -                                                         
    SP3:                                      -     -                       -     -           -                                                         
    SP4:                                            -                       -                 -                                                         
    SP5:                                                                    -                 -                                                         


    ECgene alternative splicing isoforms for TOE1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TOE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGGACCATA
    TOE1 Expression
    About this image

    TOE1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TOE1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.525091
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOE1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TOE1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Toe11 , 5 target of EGR1, member 1 (nuclear)1, 5 84.38(n)1
    81.76(a)1
      4 (53.33 cM)5
    682761  NM_026654.21  NP_080930.11 
     1167943105 
    chicken
    (Gallus gallus)
    Aves TOE11 target of EGR1, member 1 (nuclear) 62.47(n)
    60.13(a)
      424595  XM_422434.4  XP_422434.2 
    lizard
    (Anolis carolinensis)
    Reptilia TOE16
    target of EGR1, member 1 (nuclear)
    52(a)
    1 ↔ 1
    4(110217537-110257100)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.339242 Xenopus laevis transcribed sequence with weak similarity more 74.73(n)    BU899752.1 
    zebrafish
    (Danio rerio)
    Actinopterygii toe11 target of EGR1, member 1 (nuclear) 59.09(n)
    56.73(a)
      568260  NM_001256682.1  NP_001243611.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_Y57A10A.251 CELE_Y57A10A.25 47.93(n)
    37.47(a)
      174866  NM_064201.3  NP_496602.1 


    ENSEMBL Gene Tree for TOE1 (if available)
    TreeFam Gene Tree for TOE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TOE1 gene

    Find genes that share paralogs with TOE1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TOE1
    PGOHUM00000246821


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TOE1 (see all 48)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37486471,2
    C,H--45808172(-) GCATAG/AAAGTT 2 /F syn1 ese36Minor allele frequency- A:0.00NS EA NA 418
    rs1854061091,2
    C--45808199(+) CTGGGA/TACCTT 2 G syn10--------
    rs2014031651,2
    --45808280(+) CGTTTC/TGTGGC 2 F syn10--------
    rs1378966241,2
    F--45808281(+) GTTTCG/ATGGCC 2 /M /V mis11Minor allele frequency- A:0.00NA 4552
    rs412691071,2
    C--45808469(+) TCTTAC/TGGAGC 1 -- int10--------
    rs1127749971,2
    C--45808498(+) TTACCC/TTCTTG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs2010200601,2
    --45808526(+) GGAAAA/TTGGGA 2 N I mis10--------
    rs1448292691,2
    C--45808538(+) GCAGCG/AGGCAG 2 /Q /R mis11Minor allele frequency- A:0.00NA 4546
    rs1476255971,2
    --45808542(+) CGGGCA/GGCTGG 2 A syn10--------
    rs1422712201,2
    C,F--45808589(+) TTCCAG/CCATGA 2 /T /S mis11Minor allele frequency- C:0.00NA 4552

    HapMap Linkage Disequilibrium report for TOE1 (45805342 - 45809650 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TOE1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2750837CNV Loss17911159

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TOE1
    DNA2.0 Custom Variant and Variant Library Synthesis for TOE1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613931    OMIM disorders: --


    Find genes that share disorders with TOE1           About GenesLikeMe


    Export disorders for TOE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TOE1 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with TOE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. In vivo cloning and characterization of a new growth suppressor protein TOE1 as a direct target gene of Egr1. (PubMed id 12562764)1, 2, 3 De Belle I.... Adamson E.D. (J. Biol. Chem. 2003)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6. (PubMed id 23151878)1 Evsyukova I....Garcia-Blanco M.A. (RNA 2013)
    7. Dynamic protein-protein interaction wiring of the human spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (Mol. Cell 2012)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (amp 2012)
    10. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Free Text  

      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 114034 HGNC: 15954 AceView: TOE1 Ensembl:ENSG00000132773 euGenes: HUgn114034
    ECgene: TOE1 H-InvDB: TOE1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TOE1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TOE1 gene:
    Search GeneIP for patents involving TOE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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