TOE1 Gene
protein-coding GIFtS: 50
GCID: GC01P045805
|
|
target of EGR1, member 1 (nuclear)
| |
Aliases
for TOE1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Target Of EGR1, Member 1 (Nuclear)1 2 | | Target Of EGR1 Protein 12 |
Export aliases for TOE1 gene to outside databasesPrevious GC identifers: GC00U991071 GC01P045235 GC01P045218 GC01P045474 GC01P045577 GC01P043916 |
Summaries
for TOE1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TOE1_HUMAN, Q96GM8Function: Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediatesthe inhibitory growth effect of EGR1
Gene Wiki entry for TOE1
|
Genomic Views
for TOE1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TOE1 gene promoter:
E2F-3a E2F-4 STAT1 E2F-5 E2F-2 Evi-1 HEN1 E2F E2F-1 FOXO4
Other transcription factors
Search SABiosciences Chromatin IP Primers for TOE1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOE1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p33 Ensembl cytogenetic band: 1p34.1 HGNC cytogenetic band: 1p33TOE1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P045805: view genomic region
(about GC identifiers)
Start:
|
45,805,342 bp from pter |
End:
|
45,809,650 bp from pter |
Size:
|
4,309 bases |
Orientation:
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plus strand |
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Proteins
for TOE1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TOE1_HUMAN, Q96GM8 (See
protein sequence)Recommended Name: Target of EGR1 protein 1 Size: 510 amino acids; 56548 Da
Subcellular location: Nucleus, nucleolus. Nucleus speckle. Note=Localizes to nuclear speckles
1 PDB 3D structure from  and Proteopedia  for TOE1:2FC6 (3D)
Secondary accessions: Q6IA35 Q8IWN5 Q9H846Explore the universe of human proteins at neXtProt for TOE1: NX_Q96GM8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96GM8
TOE1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079353.3
ENSEMBL proteins: ENSP00000361162 ENSP00000438900
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TOE1 for ontologies About GeneDecksing
TOE1 Antibody Products:
Assay Products for TOE1: |
Protein
Domains /
Families
for TOE1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TOE1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96GM8ProtoNet protein and cluster: Q96GM8 1 Blocks protein family: IPB000571 Zn-finger
UniProtKB/Swiss-Prot: TOE1_HUMAN, Q96GM8Similarity: Belongs to the CAF1 familySimilarity: Contains 1 C3H1-type zinc finger |
Function
for TOE1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TOE1_HUMAN, Q96GM8Function: Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediatesthe inhibitory growth effect of EGR1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOE1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOE1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: TOE1 (NM_025077) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TOE1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOE1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOE1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
TOE1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for TOE1:
|
Pathways & Interactions
for TOE1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TOE1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 24)
5/36 Interacting proteins for TOE1 (Q96GM82, 3 ENSP000003611624) via UniProtKB, MINT, STRING, and/or I2D (see all 36)About this table
|
Drugs & Compounds
for TOE1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TOE1
Search CenterWatch for drugs/clinical trials and news about TOE1
|
Transcripts
for TOE1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TOE1 gene: NM_025077.3 Unigene Cluster for TOE1: Target of EGR1, member 1 (nuclear) Hs.525091 [show with all ESTs]Unigene Representative Sequence: NM_0250776 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372090(uc009vxq.3 uc010olm.2) ENST00000477731 ENST00000471337
ENST00000495703(uc010oln.1 uc001cnr.4) ENST00000460057 ENST00000539779
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOE1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOE1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TOE1 (NM_025077) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TOE1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOE1 |
Additional cDNA sequence: AK024011.1 AK293704.1 AK298162.1 AY169960.1 BC009364.2 CR457320.1 18 DOTS entries: DT.100708959 DT.416232 DT.97854702 DT.100663193 DT.99937199 DT.412280 DT.95178812 DT.97798730 DT.100765377 DT.121426007 DT.92443341 DT.100663185 DT.92059999 DT.121425936 DT.121425745 DT.100870054 DT.92443342 DT.95088446 24/186 AceView cDNA sequences (see all 186): BM664633 AL709966 CR591540 BE618211 CA309041 CR601438 BM786025 AA306293 BM787979 BI834157 BM449673 BG007074 BE790983 BI832558 AW272536 AI590068 BU623437 BX338089 AA866144 BU618393 BC009364 BG257276 AI745510 BX395622
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TOE1 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f | ^ | 9 | ^ | 10 |
|---|
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| SP1: | | | | | | | | | | | - | | - | | - | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TOE1
|
Expression
for TOE1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TOE1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGGACCATA
About this image
See TOE1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TOE1
SOURCE GeneReport for Unigene cluster: Hs.525091
SABiosciences Custom PCR Arrays for TOE1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOE1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TOE1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOE1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOE1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOE1 |
Orthologs
for TOE1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TOE1 gene from 6/21 species (see all 21) About this table
ENSEMBL Gene Tree for TOE1 (if available)
TreeFam Gene Tree for TOE1 (if available) |
Paralogs
for TOE1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TOE1 gene
TOE1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TOE1
PGOHUM00000246821
|
Genomic Variants
for TOE1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TOE1 (45805342 - 45809650 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TOE1
1 CNV: 8915 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOE1 |
|
Disorders
/ Diseases
for TOE1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TOE1 for disorders About GeneDecksing
OMIM gene information: 613931
OMIM disorders: --
1  disease for TOE1: About MalaCardsintermittent claudication
Export disorders for TOE1 gene to outside databases
|
Publications
for TOE1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TOE1 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with TOE1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- In vivo cloning and characterization of a new growth suppressor protein TOE1 as a direct target gene of Egr1. (PubMed id 12562764)1, 2, 3 De Belle I.... Adamson E.D. (2003)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
|
External Searches for TOE1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TOE1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TOE1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TOE1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TOE1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TOE1 gene:
Search GeneIP for patents involving TOE1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TOE1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TOE1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TOE1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOE1 | | | OriGene Protein Over-expression Lysate for TOE1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TOE1 | | OriGene 3'-UTR Clone for TOE1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOE1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOE1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TOE1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TOE1 | | OriGene Custom Protein Services for TOE1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TOE1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOE1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOE1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOE1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOE1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOE1 |
| |
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| | | | Search Tocris compounds for TOE1 |
| |  |  |  |  | | | | |
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 | | | TOE1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOE1 |
|  |  |  | | | | Search ThermoFisher Antibodies for TOE1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOE1 |
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