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Aliases for TOE1 Gene

Aliases for TOE1 Gene

  • Target Of EGR1, Member 1 (Nuclear) 2 3

External Ids for TOE1 Gene

Previous GeneCards Identifiers for TOE1 Gene

  • GC00U991071
  • GC01P045235
  • GC01P045218
  • GC01P045474
  • GC01P045577
  • GC01P045805
  • GC01P043916

Summaries for TOE1 Gene

GeneCards Summary for TOE1 Gene

TOE1 (Target Of EGR1, Member 1 (Nuclear)) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for TOE1 Gene

  • Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1.

Gene Wiki entry for TOE1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOE1 Gene

Genomics for TOE1 Gene

Regulatory Elements for TOE1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TOE1 Gene

45,339,670 bp from pter
45,343,978 bp from pter
4,309 bases
Plus strand

Genomic View for TOE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TOE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOE1 Gene

Proteins for TOE1 Gene

  • Protein details for TOE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Target of EGR1 protein 1
    Protein Accession:
    Secondary Accessions:
    • B4DEM6
    • Q6IA35
    • Q8IWN5
    • Q9H846

    Protein attributes for TOE1 Gene

    510 amino acids
    Molecular mass:
    56548 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TOE1 Gene

    Alternative splice isoforms for TOE1 Gene


neXtProt entry for TOE1 Gene

Proteomics data for TOE1 Gene at MOPED

Post-translational modifications for TOE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TOE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TOE1 Gene

Domains for TOE1 Gene

Protein Domains for TOE1 Gene

Suggested Antigen Peptide Sequences for TOE1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CAF1 family.
  • Contains 1 C3H1-type zinc finger.
  • Belongs to the CAF1 family.
  • Contains 1 C3H1-type zinc finger.
genes like me logo Genes that share domains with TOE1: view

No data available for Gene Families for TOE1 Gene

Function for TOE1 Gene

Molecular function for TOE1 Gene

UniProtKB/Swiss-Prot Function:
Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1.

Gene Ontology (GO) - Molecular Function for TOE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 19508870
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TOE1: view

Phenotypes for TOE1 Gene

GenomeRNAi human phenotypes for TOE1:
genes like me logo Genes that share phenotypes with TOE1: view

Animal Model Products

miRNA for TOE1 Gene

miRTarBase miRNAs that target TOE1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TOE1 Gene

Localization for TOE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOE1 Gene

Nucleus, nucleolus. Nucleus speckle. Note=Localizes to nuclear speckles.

Subcellular locations from

Jensen Localization Image for TOE1 Gene COMPARTMENTS Subcellular localization image for TOE1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TOE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with TOE1: view

Pathways for TOE1 Gene

SuperPathways for TOE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TOE1 Gene


No data available for Pathways by source for TOE1 Gene

Transcripts for TOE1 Gene

Unigene Clusters for TOE1 Gene

Target of EGR1, member 1 (nuclear):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TOE1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOE1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9 ^ 10
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - -
SP5: - -
SP6: - - - - - -
SP7: - - - -
SP8: - - -

Relevant External Links for TOE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TOE1 Gene

mRNA expression in normal human tissues for TOE1 Gene

Protein differential expression in normal tissues for TOE1 Gene

This gene is overexpressed in Breast (38.6) and Lung (20.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TOE1 Gene

SOURCE GeneReport for Unigene cluster for TOE1 Gene Hs.525091

genes like me logo Genes that share expressions with TOE1: view

Expression partners for TOE1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TOE1 Gene

Orthologs for TOE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TOE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TOE1 35
  • 87.65 (n)
  • 87.84 (a)
TOE1 36
  • 85 (a)
(Canis familiaris)
Mammalia TOE1 35
  • 87.88 (n)
  • 89.16 (a)
TOE1 36
  • 89 (a)
(Mus musculus)
Mammalia Toe1 35
  • 84.38 (n)
  • 81.76 (a)
Toe1 16
Toe1 36
  • 82 (a)
(Pan troglodytes)
Mammalia TOE1 35
  • 99.54 (n)
  • 99.22 (a)
TOE1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Toe1 35
  • 85.96 (n)
  • 85.79 (a)
(Monodelphis domestica)
Mammalia TOE1 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
-- 36
  • 57 (a)
(Gallus gallus)
Aves TOE1 35
  • 62.47 (n)
  • 60.13 (a)
TOE1 36
  • 52 (a)
(Anolis carolinensis)
Reptilia TOE1 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15814 35
toe1 35
  • 60.78 (n)
  • 58.19 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33924 35
(Danio rerio)
Actinopterygii toe1 35
  • 59.09 (n)
  • 56.73 (a)
toe1 36
  • 52 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11004 35
(Caenorhabditis elegans)
Secernentea CELE_Y57A10A.25 35
  • 47.93 (n)
  • 37.47 (a)
parn-2 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for TOE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TOE1 Gene

Gene Tree for TOE1 (if available)
Gene Tree for TOE1 (if available)

Paralogs for TOE1 Gene Pseudogenes for TOE1 Gene

genes like me logo Genes that share paralogs with TOE1: view

No data available for Paralogs for TOE1 Gene

Variants for TOE1 Gene

Sequence variations from dbSNP and Humsavar for TOE1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3748647 -- 45,342,500(-) GCATA(A/G)AAGTT reference, synonymous-codon, nc-transcript-variant
rs9429157 - 45,343,191(+) ACGAC(A/G)TAGGG missense, reference, nc-transcript-variant
rs41269107 -- 45,342,797(+) TCTTA(C/T)GGAGC intron-variant, nc-transcript-variant
rs61323219 - 45,343,310(+) AAACC(A/G)AGCAG missense, reference, nc-transcript-variant
rs112774997 -- 45,342,826(+) TTACC(C/T)TCTTG intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for TOE1 Gene

Variant ID Type Subtype PubMed ID
esv2750837 CNV Loss 17911159

Relevant External Links for TOE1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOE1 Gene

Disorders for TOE1 Gene

No disorders were found for TOE1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TOE1 Gene

Publications for TOE1 Gene

  1. In vivo cloning and characterization of a new growth suppressor protein TOE1 as a direct target gene of Egr1. (PMID: 12562764) De Belle I. … Adamson E.D. (J. Biol. Chem. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for TOE1 Gene

Sources for TOE1 Gene

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