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Aliases for TOB2 Gene

Aliases for TOB2 Gene

  • Transducer Of ERBB2, 2 2 3 5
  • Transducer Of ErbB-2 2 3 4
  • Protein Tob4 3 4
  • TROB2 3 4
  • TOB4 3 4
  • KIAA1663 4
  • TOBL 3

External Ids for TOB2 Gene

Previous HGNC Symbols for TOB2 Gene

  • TROB2

Previous GeneCards Identifiers for TOB2 Gene

  • GC22M038444
  • GC22M040072
  • GC22M040153
  • GC22M041829
  • GC22M024795

Summaries for TOB2 Gene

Entrez Gene Summary for TOB2 Gene

  • TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM, Apr 2004]

GeneCards Summary for TOB2 Gene

TOB2 (Transducer Of ERBB2, 2) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay and Signaling by BMP. GO annotations related to this gene include vitamin D receptor binding. An important paralog of this gene is TOB1.

UniProtKB/Swiss-Prot for TOB2 Gene

  • Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases.

Gene Wiki entry for TOB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOB2 Gene

Genomics for TOB2 Gene

Regulatory Elements for TOB2 Gene

Enhancers for TOB2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TOB2 on UCSC Golden Path with GeneCards custom track

Promoters for TOB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TOB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TOB2 Gene

41,433,488 bp from pter
41,448,230 bp from pter
14,743 bases
Minus strand

Genomic View for TOB2 Gene

Genes around TOB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOB2 Gene

Proteins for TOB2 Gene

  • Protein details for TOB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Tob2
    Protein Accession:
    Secondary Accessions:
    • Q6FHR7
    • Q6PIT9
    • Q9BY97
    • Q9UBI0

    Protein attributes for TOB2 Gene

    344 amino acids
    Molecular mass:
    36632 Da
    Quaternary structure:
    • Associates with CAF1.
    • Sequence=BAB33333.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TOB2 Gene


neXtProt entry for TOB2 Gene

Proteomics data for TOB2 Gene at MOPED

Post-translational modifications for TOB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TOB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TOB2 Gene

Domains & Families for TOB2 Gene

Protein Domains for TOB2 Gene

Suggested Antigen Peptide Sequences for TOB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BTG family.
  • Belongs to the BTG family.
genes like me logo Genes that share domains with TOB2: view

No data available for Gene Families for TOB2 Gene

Function for TOB2 Gene

Molecular function for TOB2 Gene

UniProtKB/Swiss-Prot Function:
Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases.
genes like me logo Genes that share phenotypes with TOB2: view

Animal Models for TOB2 Gene

MGI Knock Outs for TOB2:

Animal Model Products

miRNA for TOB2 Gene

miRTarBase miRNAs that target TOB2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TOB2 Gene

Localization for TOB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOB2 Gene


Subcellular locations from

Jensen Localization Image for TOB2 Gene COMPARTMENTS Subcellular localization image for TOB2 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TOB2 Gene

Pathways & Interactions for TOB2 Gene

genes like me logo Genes that share pathways with TOB2: view

Pathways by source for TOB2 Gene

1 BioSystems pathway for TOB2 Gene
1 KEGG pathway for TOB2 Gene

Gene Ontology (GO) - Biological Process for TOB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010468 regulation of gene expression IEA --
GO:0045778 positive regulation of ossification IEA --
genes like me logo Genes that share ontologies with TOB2: view

No data available for SIGNOR curated interactions for TOB2 Gene

Drugs & Compounds for TOB2 Gene

No Compound Related Data Available

Transcripts for TOB2 Gene

mRNA/cDNA for TOB2 Gene

Unigene Clusters for TOB2 Gene

Transducer of ERBB2, 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TOB2 Gene

ExUns: 1a · 1b ^ 2a · 2b

Relevant External Links for TOB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TOB2 Gene

mRNA expression in normal human tissues for TOB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TOB2 Gene

SOURCE GeneReport for Unigene cluster for TOB2 Gene Hs.474978

mRNA Expression by UniProt/SwissProt for TOB2 Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with TOB2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for TOB2 Gene

Orthologs for TOB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TOB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TOB2 35
  • 89.63 (n)
  • 91.86 (a)
TOB2 36
  • 94 (a)
(Canis familiaris)
Mammalia TOB2 35
  • 88.96 (n)
  • 91.34 (a)
TOB2 36
  • 93 (a)
(Mus musculus)
Mammalia Tob2 35
  • 87.89 (n)
  • 89.83 (a)
Tob2 16
Tob2 36
  • 90 (a)
(Pan troglodytes)
Mammalia TOB2 35
  • 99.9 (n)
  • 99.71 (a)
(Rattus norvegicus)
Mammalia Tob2 35
  • 87.89 (n)
  • 91.57 (a)
(Monodelphis domestica)
Mammalia TOB2 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia TOB2 36
  • 85 (a)
(Gallus gallus)
Aves TOB2 35
  • 81.24 (n)
  • 86.53 (a)
TOB2 36
  • 82 (a)
(Anolis carolinensis)
Reptilia TOB2 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2119 35
tob2 35
  • 71.92 (n)
  • 80.54 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12100 35
(Danio rerio)
Actinopterygii tob1b 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tob 37
  • 55 (a)
Tob 36
  • 25 (a)
Species with no ortholog for TOB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TOB2 Gene

Gene Tree for TOB2 (if available)
Gene Tree for TOB2 (if available)

Paralogs for TOB2 Gene

Paralogs for TOB2 Gene

(5) SIMAP similar genes for TOB2 Gene using alignment to 3 proteins: Pseudogenes for TOB2 Gene

genes like me logo Genes that share paralogs with TOB2: view

Variants for TOB2 Gene

Sequence variations from dbSNP and Humsavar for TOB2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs6609 -- 41,433,790(-) GATGT(C/G)TTTTT utr-variant-3-prime
rs79005 -- 41,439,540(+) AGACT(A/G)AGTCT intron-variant
rs106860 -- 41,444,403(-) TTCCT(A/G)GCTCC intron-variant, utr-variant-5-prime
rs34109631 -- 41,433,896(+) AAAGG(-/T)TTTAT utr-variant-3-prime
rs34272944 -- 41,442,951(+) CGGCG(-/A)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TOB2 Gene

Variant ID Type Subtype PubMed ID
nsv524585 CNV Loss 19592680
nsv915119 CNV Loss 21882294
nsv459888 CNV Gain 19166990
nsv516925 CNV Loss 19592680
nsv834207 CNV Loss 17160897
nsv834208 CNV Loss 17160897

Variation tolerance for TOB2 Gene

Residual Variation Intolerance Score: 68.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.39; 27.37% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TOB2 Gene

Disorders for TOB2 Gene

Relevant External Links for TOB2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TOB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TOB2 Gene

Publications for TOB2 Gene

  1. Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases. (PMID: 10602502) Ikematsu N. … Yamamoto T. (Oncogene 1999) 2 3 4 23 67
  2. Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex. (PMID: 11429045) Yoshida Y. … Yamamoto T. (Jpn. J. Cancer Res. 2001) 3 23
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3
  4. Upregulation of miR-362-3p Modulates Proliferation and Anchorage-Independent Growth by Directly Targeting Tob2 in Hepatocellular Carcinoma. (PMID: 25649327) Shen H. … Li Y. (J. Cell. Biochem. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for TOB2 Gene

Sources for TOB2 Gene