Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TOB2 Gene

protein-coding   GIFtS: 60
GCID: GC22M041829

Transducer Of ERBB2, 2


(Previous symbol: TROB2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Transducer Of ERBB2, 21 2     TOB42 3
TROB21 2 3     KIAA16633 5
Protein Tob42 3     TOBL2
Transducer Of ErbB-2 22 3     Protein Tob22

External Ids:    HGNC: 119801   Entrez Gene: 107662   Ensembl: ENSG000001838647   OMIM: 6073965   UniProtKB: Q141063   

Export aliases for TOB2 gene to outside databases

Previous GC identifers: GC22M038444 GC22M040072 GC22M040153 GC22M024795


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TOB2 Gene:
TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are
involved in the regulation of cell cycle progression.(supplied by OMIM, Apr 2004)

GeneCards Summary for TOB2 Gene:
TOB2 (transducer of ERBB2, 2) is a protein-coding gene. Diseases associated with TOB2 include vitiligo, and breast cancer. GO annotations related to this gene include vitamin D receptor binding. An important paralog of this gene is BTG4.

UniProtKB/Swiss-Prot: TOB2_HUMAN, Q14106
Function: Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases

Gene Wiki entry for TOB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000022.11  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TOB2 gene promoter:
         NF-YB   CBF-B   CBF-A   NF-YA   NF-YC   CP1C   CP1A   CBF(2)   CBF-C   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TOB2 promoter sequence
   Search Chromatin IP Primers for TOB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TOB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.2   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.2

TOB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOB2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M041829:  view genomic region     (about GC identifiers)

Start:
41,829,492 bp from pter      End:
41,843,027 bp from pter
Size:
13,536 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TOB2_HUMAN, Q14106 (See protein sequence)
Recommended Name: Protein Tob2  
Size: 344 amino acids; 36632 Da
Subunit: Associates with CAF1
Sequence caution: Sequence=BAB33333.1; Type=Erroneous initiation;
Secondary accessions: Q6FHR7 Q9BY97 Q9UBI0

Explore the universe of human proteins at neXtProt for TOB2: NX_Q14106

Explore proteomics data for TOB2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TOB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057356.1  
    ENSEMBL proteins: 
     ENSP00000331305   ENSP00000388549  

    TOB2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TOB2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TOB2
    GenScript Custom Purified and Recombinant Proteins Services for TOB2
    Novus Biologicals TOB2 Protein
    Novus Biologicals TOB2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TOB2

    TOB2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TOB2
    OriGene Custom Antibody Services for TOB2
    Novus Biologicals TOB2 Antibodies
    Abcam antibodies for TOB2
    Cloud-Clone Corp. Antibodies for TOB2
    ThermoFisher Antibodies for TOB2
    LSBio Antibodies in human, mouse, rat for TOB2

    TOB2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TOB2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TOB2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TOB2
    Cloud-Clone Corp. CLIAs for TOB2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR009818 Ataxin-2_C
     IPR015676 Tob
     IPR002087 Anti_prolifrtn
     IPR015678 Tob2

    Graphical View of Domain Structure for InterPro Entry Q14106

    ProtoNet protein and cluster: Q14106

    2 Blocks protein domains:
    IPB002087 Anti-proliferative protein
    IPB009818 Ataxin-2


    UniProtKB/Swiss-Prot: TOB2_HUMAN, Q14106
    Similarity: Belongs to the BTG family


    TOB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TOB2_HUMAN, Q14106
    Function: Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0042809vitamin D receptor binding IEA--
         
    TOB2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TOB2:
     Decreased POU5F1-GFP protein e 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tob2):
     cellular  hematopoietic system  immune system  skeleton 

    TOB2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TOB2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TOB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TOB2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TOB2

    miRNA
    Products:
        
    miRTarBase miRNAs that target TOB2:
    hsa-mir-320a (MIRT044604), hsa-mir-378a-3p (MIRT005483), hsa-mir-122-5p (MIRT023391), hsa-mir-221-3p (MIRT046940), hsa-mir-302a-3p (MIRT006203), hsa-mir-744-5p (MIRT037545), hsa-mir-106b-3p (MIRT038591), hsa-mir-877-5p (MIRT037245)

    Block miRNA regulation of human, mouse, rat TOB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TOB2 (see all 108):
    hsa-miR-520e hsa-miR-4272 hsa-miR-219-5p hsa-miR-3653 hsa-miR-3613-3p hsa-miR-155* hsa-miR-92b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidTOB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TOB2
    Predesigned siRNA for gene silencing in human, mouse, rat TOB2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TOB2

    Clone
    Products:
         
    OriGene clones in human, mouse for TOB2 (see all 7)
    OriGene ORF clones in mouse, rat for TOB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TOB2 (NM_016272)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOB2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TOB2
    Browse ESI BIO Cell Lines and PureStem Progenitors for TOB2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOB2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TOB2_HUMAN, Q14106: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    extracellular1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10602502
    GO:0005737cytoplasm IEA--

    TOB2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TOB2 About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    RNA degradation0.48
    2Signaling by BMP
    BMP signalling and regulation0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TOB2
        BMP signalling and regulation


    1 Kegg Pathway  (Kegg details for TOB2):
        RNA degradation


    TOB2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TOB2
    Interactions:

        Search GeneGlobe Interaction Network for TOB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for TOB2 (Q141061, 2, 3 ENSP000003313054) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CPEB3Q8NE352, 3, ENSP000002659974MINT-8176448 I2D: score=1 STRING: ENSP00000265997
    CNOT7Q9UIV13, ENSP000003552794I2D: score=2 STRING: ENSP00000355279
    RPS6KA1Q154183, ENSP000003632774I2D: score=2 STRING: ENSP00000363277
    VDRP114733, ENSP000002290224I2D: score=1 STRING: ENSP00000229022
    PABPC1P119401EBI-2562000,EBI-81531
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007292female gamete generation TAS10602502
    GO:0008285negative regulation of cell proliferation TAS10602502
    GO:0010468regulation of gene expression IEA--
    GO:0045671negative regulation of osteoclast differentiation IEA--
    GO:0045778positive regulation of ossification IEA--

    TOB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TOB2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TOB2 gene: 
    NM_016272.3  

    Unigene Cluster for TOB2:

    Transducer of ERBB2, 2
    Hs.474978  [show with all ESTs]
    Unigene Representative Sequence: NM_016272
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327492(uc003azz.1) ENST00000434408
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TOB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TOB2 (see all 108):
    hsa-miR-520e hsa-miR-4272 hsa-miR-219-5p hsa-miR-3653 hsa-miR-3613-3p hsa-miR-155* hsa-miR-92b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidTOB2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TOB2
    Predesigned siRNA for gene silencing in human, mouse, rat TOB2
    Clone
    Products:
         
    OriGene clones in human, mouse for TOB2 (see all 7)
    OriGene ORF clones in mouse, rat for TOB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TOB2 (NM_016272)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOB2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TOB2
    OriGene qSTAR qPCR primer pairs in human, mouse for TOB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TOB2
      QuantiTect SYBR Green Assays in human, mouse, rat TOB2
      QuantiFast Probe-based Assays in human, mouse, rat TOB2

    Additional mRNA sequence: 

    AB035207.1 AB051450.1 AL133080.1 BC038957.1 CR456594.1 CR541684.1 D64109.1 

    9 DOTS entries:

    DT.212023  DT.95276261  DT.99946039  DT.99999081  DT.100821273  DT.87001086  DT.91748775  DT.95276263 
    DT.121499280 

    Selected AceView cDNA sequences (see all 330):

    BM473927 CR601882 BX500842 BX488925 AA689493 BG764318 AB051450 BF769782 
    BM550270 BE048297 BX374991 BQ223444 BU521142 CR456594 AI190831 BQ185645 
    BM795385 BU521126 BM474715 BQ889066 AW002647 BQ719948 BM924676 CD676094 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TOB2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for TOB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TOB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATACATAATA
    TOB2 Expression
    About this image


    TOB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule
    TOB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TOB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.474978

    UniProtKB/Swiss-Prot: TOB2_HUMAN, Q14106
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for TOB2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TOB2
    OriGene qSTAR qPCR primer pairs in human, mouse for TOB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TOB2
    QuantiTect SYBR Green Assays in human, mouse, rat TOB2
    QuantiFast Probe-based Assays in human, mouse, rat TOB2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for TOB2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tob21 , 5 transducer of ERBB2, 21, 5 87.89(n)1
    89.83(a)1
      15 (38.26 cM)5
    572591  NM_020507.31  NP_065253.11 
     818482705 
    chicken
    (Gallus gallus)
    Aves TOB21 transducer of ERBB2, 2 81.24(n)
    86.53(a)
      417992  NM_001012534.1  NP_001012552.1 
    lizard
    (Anolis carolinensis)
    Reptilia TOB26
    transducer of ERBB2, 2
    81(a)
    1 ↔ 1
    5(26454027-26455065)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.121002 Xenopus laevis mRNA for Tob, complete cds 78.84(n)    AB056893.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tob1b6
    transducer of ERBB2, 1b
    62(a)
    many ↔ many
    12(1044228-1047498) ENSDARG00000021372
    fruit fly
    (Drosophila melanogaster)
    Insecta Tob3 negative regulation of cell
    proliferation
    55(a)   14A8   --


    ENSEMBL Gene Tree for TOB2 (if available)
    TreeFam Gene Tree for TOB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TOB2 gene
    BTG42  TOB12  BTG12  BTG32  BTG22  
    5 SIMAP similar genes for TOB2 using alignment to 3 protein entries:     TOB2_HUMAN (see all proteins):
    pp14762    TOB1    BTG1    BTG2    BTG4

    TOB2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TOB2
    PGOHUM00000243100


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TOB2 (see all 307)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1449003631,2
    --41829020(+) AAGGGC/TTGAGA 1 -- ds50010--------
    rs1926583921,2
    --41829070(+) AAGCTC/GTTCTC 1 -- ds50010--------
    rs72850411,2
    C,F,A,H--41829149(+) TCCCCT/GCTCTC 1 -- ds500125Minor allele frequency- G:0.14NS EA NA WA CSA 2231
    rs1828718631,2
    --41829170(+) GAATAA/GACAAT 1 -- ds50010--------
    rs1458713131,2
    C--41829180(+) TTCCT-/AAAG  
     AGCCATG
    AAGTA
    1 -- ds50010--------
    rs60023821,2
    F,H--41829320(+) ATCCTG/TTGTTG 1 -- ds50014Minor allele frequency- T:0.00NS EA 420
    rs1392444751,2
    C--41829503(+) TATTAC/TGTATC 1 -- ut310--------
    rs1884877841,2
    --41829539(+) ATCTGC/GAACAA 1 -- ut310--------
    rs563946341,2
    C--41829548(+) AATAGA/GAACTG 1 -- ut310--------
    rs1928810801,2
    --41829707(+) TCCCCA/GGGCTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TOB2 (41829492 - 41843027 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TOB2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834208CNV Loss17160897
    nsv516925CNV Loss19592680
    nsv834207CNV Loss17160897
    nsv915119CNV Loss21882294
    nsv524585CNV Loss19592680
    nsv459888CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TOB2
    DNA2.0 Custom Variant and Variant Library Synthesis for TOB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607396    OMIM disorders: --

    3 diseases for TOB2:    
    About MalaCards
    vitiligo    breast cancer    neuronitis


    TOB2 for disorders           About GeneDecksing


    Export disorders for TOB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TOB2 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with TOB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases. (PubMed id 10602502)1, 2, 3, 9 Ikematsu N.... Yamamoto T. (Oncogene 1999)
    2. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I.... Wright H. (Nature 1999)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    5. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PubMed id 11258795)1, 2 Hirosawa M.... Ohara O. (DNA Res. 2001)
    6. Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex. (PubMed id 11429045)1, 9 Yoshida Y....Yamamoto T. (Jpn. J. Cancer Res. 2001)
    7. Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo. (PubMed id 22561518)1 Jin Y....Spritz R.A. (Nat. Genet. 2012)
    8. Evidence providing new insights into TOB-promoted deadenylation and supporting a link between TOB's deadenylation-enhancing and antiproliferative activities. (PubMed id 22252318)1 Ezzeddine N....Shyu A.B. (Mol. Cell. Biol. 2012)
    9. Myc/miR-378/TOB2/cyclin D1 functional module regulates oncogenic transformation. (PubMed id 21242960)1 Feng M....Yu Q. (Oncogene 2011)
    10. Mammalian hyperplastic discs homolog EDD regulates miRNA-mediated gene silencing. (PubMed id 21726813)1 Su H....Wang X. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10766 HGNC: 11980 AceView: TOB2 Ensembl:ENSG00000183864 euGenes: HUgn10766
    ECgene: TOB2 Kegg: 10766 H-InvDB: TOB2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1663

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TOB2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TOB2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TOB2 gene:
    Search GeneIP for patents involving TOB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TOB2   OriGene RNAi products in human, mouse, rat for TOB2  
     OriGene qPCR primer pairs and template standards for TOB2   OriGene Protein Over-expression Lysate for TOB2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TOB2  
     OriGene qSTAR qPCR primer pairs in human, mouse for TOB2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TOB2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TOB2   OriGene Custom Protein Services for TOB2  

     
     
     Block miRNA regulation of human, mouse, rat TOB2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TOB2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TOB2 Predesigned siRNA for gene silencing in human, mouse, rat TOB2
     QuantiFast Probe-based Assays in human, mouse, rat TOB2 QuantiTect SYBR Green Assays in human, mouse, rat TOB2
     Custom PCR Arrays for TOB2 Search Chromatin IP Primers for TOB2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TOB2  Search GeneGlobe Interaction Network for TOB2
     Regulatory tfbs in TOB2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TOB2 GenScript cDNA clones with any tag delivered in your preferred vector for TOB2
     GenScript Custom Assay Services for TOB2 GenScript Custom overexpressing Cell Line Services for TOB2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TOB2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TOB2 antibodies
     TOB2 proteins
     TOB2 lysates
     Antibodies for TOB2
     See all of Abcam's Antibodies, Kits and Proteins for TOB2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TOB2
     Antibodies for TOB2
     ELISAs for TOB2
     CLIAs for TOB2



     Browse ESI BIO Cell Lines and PureStem Progenitors for TOB2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOB2
     SwitchGear 3'UTR luciferase reporter plasmids for TOB2
     SwitchGear Promoter luciferase reporter plasmids for TOB2
     ThermoFisher Antibodies for TOB2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOB2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TOB2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TOB2
     LSBio Antibodies in human, mouse, rat for TOB2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TOB2 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4