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Aliases for TOB1 Gene

Aliases for TOB1 Gene

  • Transducer Of ERBB2, 1 2 3 5
  • Transducer Of ErbB-2 1 3 4
  • TROB1 3 4
  • TOB 3 4
  • Proliferation-Inducing Gene 49 3
  • Protein Tob1 3
  • APRO5 3
  • APRO6 3
  • PIG49 3
  • TROB 3

External Ids for TOB1 Gene

Previous HGNC Symbols for TOB1 Gene

  • TROB1

Previous GeneCards Identifiers for TOB1 Gene

  • GC17M048653
  • GC17M051420
  • GC17M049281
  • GC17M049414
  • GC17M046294
  • GC17M048939
  • GC17M044308

Summaries for TOB1 Gene

Entrez Gene Summary for TOB1 Gene

  • This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for TOB1 Gene

TOB1 (Transducer Of ERBB2, 1) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay and MAPK Signaling: Mitogen Stimulation Pathway. GO annotations related to this gene include transcription corepressor activity and SMAD binding. An important paralog of this gene is TOB2.

UniProtKB/Swiss-Prot for TOB1 Gene

  • Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:8632892, PubMed:23236473). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257).

Gene Wiki entry for TOB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOB1 Gene

Genomics for TOB1 Gene

Regulatory Elements for TOB1 Gene

Enhancers for TOB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F050902 1.7 FANTOM5 Ensembl ENCODE 18.5 -39.4 -39423 10.4 HDGF PKNOX1 MLX ZFP64 ARID4B FEZF1 DMAP1 YY1 SLC30A9 FOS TOB1 ENSG00000247011 ENSG00000251665 WFIKKN2 CACNA1G-AS1 RSAD1 ENSG00000262006 LOC105371825
GH17F050889 1.3 Ensembl ENCODE 8.5 -23.8 -23766 4.8 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 SLC30A9 FOS ZNF263 SP3 TOB1-AS1 TOB1 LOC105371825 GC17M050874
GH17F050882 1.3 Ensembl ENCODE 8.2 -15.9 -15947 3.7 ATF1 ZFP64 ARID4B DMAP1 ZNF48 ZNF121 GATA2 FOS KDM4B SP5 ENSG00000247011 ENSG00000251665 WFIKKN2 TOB1-AS1 TOB1 TMEM92 GC17M050874 LOC105371825
GH17F050886 0.8 Ensembl ENCODE 8.2 -19.5 -19542 1.4 PKNOX1 PRDM10 ZBTB33 ZIC2 TOB1-AS1 TOB1 LOC105371825 GC17M050874
GH17F050914 1.8 FANTOM5 Ensembl ENCODE 1.9 -51.6 -51618 10.0 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ENSG00000251665 ENSG00000247011 LOC105371827 ENSG00000249658 LINC02071 ENSG00000206824 COL1A1 WFIKKN2 ENSG00000236472 NME2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TOB1 on UCSC Golden Path with GeneCards custom track

Promoters for TOB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001536597 1678 5001 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF263 SP3 NFYC MEF2D

Genomic Location for TOB1 Gene

Chromosome:
17
Start:
50,862,223 bp from pter
End:
50,867,978 bp from pter
Size:
5,756 bases
Orientation:
Minus strand

Genomic View for TOB1 Gene

Genes around TOB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOB1 Gene

Proteins for TOB1 Gene

  • Protein details for TOB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50616-TOB1_HUMAN
    Recommended name:
    Protein Tob1
    Protein Accession:
    P50616
    Secondary Accessions:
    • B2R9T0
    • D3DTY3
    • Q4KMQ0

    Protein attributes for TOB1 Gene

    Size:
    345 amino acids
    Molecular mass:
    38155 Da
    Quaternary structure:
    • Interacts with ERBB2 (PubMed:8632892). Interacts with CNOT7 (PubMed:19276069, PubMed:21336257, PubMed:23236473). Interacts with CPEB3 (via C-terminal RNA-binding region); recruits CNOT7 to CPEB3 to form a ternary complex required for mRNA deadenylation and decay (PubMed:21336257). Interacts with CNOT8 (PubMed:23236473). Interacts with CPEB4 (PubMed:21336257).

    Three dimensional structures from OCA and Proteopedia for TOB1 Gene

neXtProt entry for TOB1 Gene

Post-translational modifications for TOB1 Gene

Other Protein References for TOB1 Gene

No data available for DME Specific Peptides for TOB1 Gene

Domains & Families for TOB1 Gene

Gene Families for TOB1 Gene

Protein Domains for TOB1 Gene

Suggested Antigen Peptide Sequences for TOB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P50616

UniProtKB/Swiss-Prot:

TOB1_HUMAN :
  • Belongs to the BTG family.
Family:
  • Belongs to the BTG family.
genes like me logo Genes that share domains with TOB1: view

Function for TOB1 Gene

Molecular function for TOB1 Gene

UniProtKB/Swiss-Prot Function:
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:8632892, PubMed:23236473). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257).

Gene Ontology (GO) - Molecular Function for TOB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IBA --
GO:0005070 SH3/SH2 adaptor activity TAS 8632892
GO:0005515 protein binding IPI 18377426
GO:0030971 receptor tyrosine kinase binding IDA 8632892
GO:0046332 SMAD binding IEA --
genes like me logo Genes that share ontologies with TOB1: view
genes like me logo Genes that share phenotypes with TOB1: view

Animal Models for TOB1 Gene

MGI Knock Outs for TOB1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TOB1 Gene

Localization for TOB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOB1 Gene

Cytoplasm. Nucleus. Note=Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TOB1 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TOB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
GO:0005737 cytoplasm IEA,IBA --
GO:0030014 CCR4-NOT complex IDA 21336257
genes like me logo Genes that share ontologies with TOB1: view

Pathways & Interactions for TOB1 Gene

genes like me logo Genes that share pathways with TOB1: view

Pathways by source for TOB1 Gene

SIGNOR curated interactions for TOB1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for TOB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007184 SMAD protein import into nucleus IEA --
GO:0008285 negative regulation of cell proliferation IDA,TAS 8632892
GO:0009967 positive regulation of signal transduction IEA --
GO:0017148 negative regulation of translation IDA 23236473
GO:0030509 BMP signaling pathway IBA --
genes like me logo Genes that share ontologies with TOB1: view

Drugs & Compounds for TOB1 Gene

(3) Drugs for TOB1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TOB1: view

Transcripts for TOB1 Gene

Unigene Clusters for TOB1 Gene

Transducer of ERBB2, 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TOB1 Gene

No ASD Table

Relevant External Links for TOB1 Gene

GeneLoc Exon Structure for
TOB1
ECgene alternative splicing isoforms for
TOB1

Expression for TOB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TOB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TOB1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TOB1 Gene



Protein tissue co-expression partners for TOB1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TOB1 Gene:

TOB1

SOURCE GeneReport for Unigene cluster for TOB1 Gene:

Hs.703321

mRNA Expression by UniProt/SwissProt for TOB1 Gene:

P50616-TOB1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with TOB1: view

Primer Products

No data available for mRNA differential expression in normal tissues for TOB1 Gene

Orthologs for TOB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TOB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOB1 34 35
  • 99.81 (n)
dog
(Canis familiaris)
Mammalia TOB1 34 35
  • 97.49 (n)
cow
(Bos Taurus)
Mammalia TOB1 34 35
  • 96.68 (n)
oppossum
(Monodelphis domestica)
Mammalia TOB1 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TOB1 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tob1 34 16 35
  • 91.01 (n)
rat
(Rattus norvegicus)
Mammalia Tob1 34
  • 90.34 (n)
chicken
(Gallus gallus)
Aves TOB 35
  • 98 (a)
OneToOne
TOB1 34
  • 90.77 (n)
lizard
(Anolis carolinensis)
Reptilia TOB1 35
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tob1 34
  • 73.01 (n)
Str.11008 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68457 34
zebrafish
(Danio rerio)
Actinopterygii tob1a 34 35
  • 76.7 (n)
tob1 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8983 34
fruit fly
(Drosophila melanogaster)
Insecta Tob 36 35
  • 62 (a)
Species where no ortholog for TOB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TOB1 Gene

ENSEMBL:
Gene Tree for TOB1 (if available)
TreeFam:
Gene Tree for TOB1 (if available)

Paralogs for TOB1 Gene

Paralogs for TOB1 Gene

(3) SIMAP similar genes for TOB1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TOB1: view

Variants for TOB1 Gene

Sequence variations from dbSNP and Humsavar for TOB1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs111306769 -- 50,869,663(+) GCGCC(A/T)TTGCA upstream-variant-2KB
rs112426720 -- 50,866,607(+) TCCGG(A/G)CTCCA intron-variant, upstream-variant-2KB
rs112756487 -- 50,865,963(+) GAGGG(C/G)CCAGG intron-variant, upstream-variant-2KB
rs112757466 -- 50,863,460(+) CCGAA(C/T)TTGGT reference, synonymous-codon
rs113347817 -- 50,866,491(+) ACCCC(A/G)GTCCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TOB1 Gene

Variant ID Type Subtype PubMed ID
nsv1112713 CNV deletion 24896259

Variation tolerance for TOB1 Gene

Residual Variation Intolerance Score: 43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TOB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TOB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOB1 Gene

Disorders for TOB1 Gene

Relevant External Links for TOB1

Genetic Association Database (GAD)
TOB1
Human Genome Epidemiology (HuGE) Navigator
TOB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TOB1

No disorders were found for TOB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TOB1 Gene

Publications for TOB1 Gene

  1. Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity. (PMID: 8632892) Matsuda S. … Yamamoto T. (Oncogene 1996) 2 3 4 22 64
  2. Structural basis for the antiproliferative activity of the Tob-hCaf1 complex. (PMID: 19276069) Horiuchi M. … Inagaki F. (J. Biol. Chem. 2009) 3 4 22 64
  3. The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4- not complex. (PMID: 23236473) Doidge R. … Winkler G.S. (PLoS ONE 2012) 3 4 64
  4. Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase. (PMID: 21336257) Hosoda N. … Hoshino S. (EMBO J. 2011) 3 4 64
  5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64

Products for TOB1 Gene

Sources for TOB1 Gene

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