TOB1 Gene

Aliases
for TOB1 gene

Previous GC identifers: GC17M048653 GC17M051420 GC17M049281 GC17M049414 GC17M046294 GC17M044308

Summaries
for TOB1 gene

Genomic Views
for TOB1 gene

RefSeq DNA sequence:

NC_000017.10  NC_018928.1  NT_010783.15  

SwitchGear Promoter luciferase reporter plasmids (see all 2): TOB1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TOB1

TOB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M048939:  view genomic region     (about GC identifiers)

Proteins
for TOB1 gene

2 PDB 3D structures from and Proteopedia for TOB1:

2D5R (3D)        2Z15 (3D)    

Explore the universe of human proteins at neXtProt for TOB1: NX_P50616

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: TOB1 OriGene Custom Protein Services for TOB1
	GenScript Custom Purified and Recombinant Proteins Services for TOB1
	Novus Biologicals TOB1 Protein Novus Biologicals TOB1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TOB1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

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	R&D Systems Antibodies for TOB1
	Browse OriGene Antibodies OriGene Custom Antibody Services for TOB1
	GenScript Custom Superior Antibodies Services for TOB1
	Novus Biologicals TOB1 Antibodies
	Abcam antibodies for TOB1
	Uscn Antibodies for TOB1
	ThermoFisher Antibodies for TOB1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TOB1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TOB1

Protein Domains /
Families
for TOB1 gene

ProtoNet protein and cluster: P50616

Function
for TOB1 gene

miRNA Products:		OriGene 3'-UTR Clone: TOB1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TOB1
		8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate TOB1 (see all 49):
		hsa-miR-345 hsa-miR-429 hsa-miR-25 hsa-miR-138-2* hsa-miR-218 hsa-miR-374c hsa-miR-186 hsa-miR-889
		SwitchGear 3'UTR luciferase reporter plasmid: TOB1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TOB1 (see all 7) OriGene shRNA RFP: TOB1 OriGene siRNA: TOB1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TOB1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TOB1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TOB1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TOB1 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TOB1 (NM_005749)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOB1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOB1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TOB1
		Search LifeMap BioReagents cell lines for TOB1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOB1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Tob1)

Pathways & Interactions
for TOB1 gene

	Super-pathway	contained gene-specific pathways
1	Immune response_IL-2 activation and signaling pathway	Immune response IL-2 activation and signaling pathway 1.00 Immune response_IL-2 activation and signaling pathway 1.00
2	TOB in T-Cell Signaling	TOB in T-Cell Signaling 1.00 IL-2 Gene Expression in Activated and Quiescent T-Cells 0.40
3	TOB in Osteoblast Signaling	TOB in Osteoblast Signaling 1.00
4	Diurnally regulated genes with circadian orthologs	Diurnally regulated genes with circadian orthologs 1.00
5	Deadenylation-dependent mRNA decay	RNA degradation 0.50

1 EMD Millipore Pathway for TOB1

Immune response IL-2 activation and signaling pathway

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TOB1

	IL-2 Gene Expression in Activated and Quiescent T-Cells
	TOB in T-Cell Signaling
	TOB in Osteoblast Signaling

1 GeneGo (Thomson Reuters) Pathway for TOB1

Immune response IL-2 activation and signaling pathway

2 BioSystems Pathways for TOB1

	Diurnally regulated genes with circadian orthologs
	BMP signalling and regulation

1         Kegg Pathway  (Kegg details for TOB1)

RNA degradation

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for TOB1 gene

Transcripts
for TOB1 gene

Expression
for TOB1 gene

TOB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTAAGAGGGA

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	Head MesenchymeBranchial Arch 1Paraxial Mesoderm Cells			Bone, Skeletal Muscle
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TOB1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TOB1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TOB1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TOB1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOB1

Orthologs
for TOB1 gene

Paralogs
for TOB1 gene

Paralogs for TOB1 gene

BTG4²  TOB2²  BTG3²  BTG1²  BTG2²  

3 SIMAP similar genes for TOB1 using alignment to 1 protein entry:     TOB1_HUMAN:

TOB2    BTG1    BTG2

TOB1 for paralogs           About GeneDecksing

Genomic Variants
for TOB1 gene

10/104 NCBI SNPs in TOB1 are shown (see all 104)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs781270361,2		--	48939209(+)	TCTCTC/GCATAT	3	--	ds5001 int1		1		WA	118
rs1474717311,2		--	48939368(+)	GGGCTA/GTTAAA	3	--	int1 ds5001		0	--	--	--	--
rs1399763041,2		--	48939439(+)	AACCAC/TGATCT	3	--	ds5001 int1		0	--	--	--	--
rs93035681,2	C,F,A,H,	--	48939527(+)	TACAAC/TATAAT	3	--	ds5001 int1		31		NS EA NA WA CSA	2953
rs1828048151,2		--	48939578(+)	GACAAC/TAGGCA	3	--	int1 ds5001		0	--	--	--	--
rs1439368821,2		--	48939862(+)	TAGTTC/GATGTC	3	--	ut31		0	--	--	--	--
rs1861434801,2		--	48940061(+)	TTATTA/GGTGCC	3	--	ut31		0	--	--	--	--
rs561061591,2	C	--	48940257(+)	AGCTT-/AAAAAA	3	--	ut31		0	--	--	--	--
rs46261,2	C,F,O,A,H,	--	48940422(-)	GAGAAG/ATCTTT	6	/K	syn1		48		MN NS EA NA WA CSA EU	9939
rs33161,2	C,F,H	--	48940423(+)	AAGATT/CTCTCA	6	/K /R	mis1		9		MN NS EA NA	670

HapMap Linkage Disequilibrium report for TOB1 (48939584 - 48945339 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for TOB1: --

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TOB1

DNA2.0 Custom Variant and Variant Library Synthesis for TOB1

Disorders / Diseases
for TOB1 gene

13 diseases for TOB1

3 Novoseek disease relationships for TOB1 gene    About this table

Publications
for TOB1 gene

PubMed articles for TOB1 gene, integrated from 9 sources (see all 66): (articles sorted by number of sources associating them with TOB1)

Utopia: connect your pdf to the dynamic world of online information

1. Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity. (PubMed id 8632892)^{1, 2, 3, 9} Matsuda S.... Yamamoto T. (1996)
2. Human TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylation. (PubMed id 17785442)^{1, 3} Ezzeddine N....Shyu A.B. (2007)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
4. Regulation of subcellular localization of the antiproliferative protein Tob by its nuclear export signal and bipartite nuclear localization signal sequences. (PubMed id 15051490)^{1, 9} Maekawa M....Nishida E. (2004)
5. Alteration of expression or phosphorylation status of tob, a novel tumor suppressor gene product, is an early event in lung cancer. (PubMed id 14643028)^{1, 9} Iwanaga K....Sueoka E. (2003)
6. Identification of the Anti-proliferative protein Tob as a MAPK substrate. (PubMed id 12151396)^{1, 9} Maekawa M....Tanoue T. (2002)
7. A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob. (PubMed id 11260258)^{1, 9} Suzuki T....Yamamoto T. (2001)
8. Interaction of anti-proliferative protein Tob with poly(A)-binding protein and inducible poly(A)-binding protein: implication of Tob in translational control. (PubMed id 15676026)^{1, 9} Okochi K....Yamamoto T. (2005)
9. Cloning and characterization of the mouse tob gene. (PubMed id 9210596)^{1, 9} Yoshida Y....Yamamoto T. (1997)
10. Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells. (PubMed id 11694881)^{1, 9} Tzachanis D....Boussiotis V.A. (2001)

External Searches for TOB1 gene

Genome Databases showing TOB1 gene

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Products
for TOB1 gene