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Aliases for TOB1 Gene

Aliases for TOB1 Gene

  • Transducer Of ERBB2, 1 2 3 5
  • Transducer Of ErbB-2 1 3 4
  • TROB1 3 4
  • TOB 3 4
  • Proliferation-Inducing Gene 49 3
  • APRO6 3
  • PIG49 3
  • TROB 3

External Ids for TOB1 Gene

Previous HGNC Symbols for TOB1 Gene

  • TROB1

Previous GeneCards Identifiers for TOB1 Gene

  • GC17M048653
  • GC17M051420
  • GC17M049281
  • GC17M049414
  • GC17M046294
  • GC17M048939
  • GC17M044308

Summaries for TOB1 Gene

Entrez Gene Summary for TOB1 Gene

  • This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for TOB1 Gene

TOB1 (Transducer Of ERBB2, 1) is a Protein Coding gene. Among its related pathways are Akt Signaling Pathway and Immune response IL-2 activation and signaling pathway. GO annotations related to this gene include transcription corepressor activity and SMAD binding. An important paralog of this gene is BTG4.

UniProtKB/Swiss-Prot for TOB1 Gene

  • Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex.

Gene Wiki entry for TOB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOB1 Gene

Genomics for TOB1 Gene

Regulatory Elements for TOB1 Gene

Promoters for TOB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TOB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TOB1 Gene

50,862,223 bp from pter
50,867,978 bp from pter
5,756 bases
Minus strand

Genomic View for TOB1 Gene

Genes around TOB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOB1 Gene

Proteins for TOB1 Gene

  • Protein details for TOB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Tob1
    Protein Accession:
    Secondary Accessions:
    • B2R9T0
    • D3DTY3
    • Q4KMQ0

    Protein attributes for TOB1 Gene

    345 amino acids
    Molecular mass:
    38155 Da
    Quaternary structure:
    • Interacts with ERBB2. Interacts with CNOT7 and CNOT8.

    Three dimensional structures from OCA and Proteopedia for TOB1 Gene

neXtProt entry for TOB1 Gene

Proteomics data for TOB1 Gene at MOPED

Post-translational modifications for TOB1 Gene

Other Protein References for TOB1 Gene

Antibody Products

No data available for DME Specific Peptides for TOB1 Gene

Domains & Families for TOB1 Gene

Protein Domains for TOB1 Gene

Suggested Antigen Peptide Sequences for TOB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BTG family.
  • Belongs to the BTG family.
genes like me logo Genes that share domains with TOB1: view

No data available for Gene Families for TOB1 Gene

Function for TOB1 Gene

Molecular function for TOB1 Gene

UniProtKB/Swiss-Prot Function:
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex.

Gene Ontology (GO) - Molecular Function for TOB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IEA --
genes like me logo Genes that share ontologies with TOB1: view
genes like me logo Genes that share phenotypes with TOB1: view

Animal Models for TOB1 Gene

MGI Knock Outs for TOB1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TOB1 Gene

Localization for TOB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOB1 Gene

Cytoplasm. Nucleus. Note=Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for TOB1 Gene COMPARTMENTS Subcellular localization image for TOB1 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for TOB1 Gene

Pathways & Interactions for TOB1 Gene

genes like me logo Genes that share pathways with TOB1: view

Pathways by source for TOB1 Gene

SIGNOR curated interactions for TOB1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for TOB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 8632892
GO:0009967 positive regulation of signal transduction TAS 8632892
GO:0030514 negative regulation of BMP signaling pathway IEA --
genes like me logo Genes that share ontologies with TOB1: view

Drugs & Compounds for TOB1 Gene

(3) Drugs for TOB1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TOB1: view

Transcripts for TOB1 Gene

Unigene Clusters for TOB1 Gene

Transducer of ERBB2, 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TOB1 Gene

No ASD Table

Relevant External Links for TOB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TOB1 Gene

mRNA expression in normal human tissues for TOB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TOB1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TOB1 Gene

SOURCE GeneReport for Unigene cluster for TOB1 Gene Hs.703321

mRNA Expression by UniProt/SwissProt for TOB1 Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with TOB1: view

Protein tissue co-expression partners for TOB1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TOB1 Gene

Orthologs for TOB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TOB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TOB1 35
  • 96.68 (n)
  • 98.83 (a)
TOB1 36
  • 99 (a)
(Canis familiaris)
Mammalia TOB1 35
  • 97.49 (n)
  • 99.42 (a)
TOB1 36
  • 70 (a)
(Mus musculus)
Mammalia Tob1 35
  • 91.01 (n)
  • 94.78 (a)
Tob1 16
Tob1 36
  • 93 (a)
(Pan troglodytes)
Mammalia TOB1 35
  • 99.81 (n)
  • 100 (a)
TOB1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tob1 35
  • 90.34 (n)
  • 94.49 (a)
(Monodelphis domestica)
Mammalia TOB1 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia TOB1 36
  • 92 (a)
(Gallus gallus)
Aves TOB1 35
  • 90.77 (n)
  • 97.23 (a)
TOB 36
  • 98 (a)
(Anolis carolinensis)
Reptilia TOB1 36
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11008 35
tob1 35
  • 73.01 (n)
  • 78.71 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68457 35
(Danio rerio)
Actinopterygii tob1 35
tob1a 35
  • 76.7 (n)
  • 84.64 (a)
tob1a 36
  • 85 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8983 35
fruit fly
(Drosophila melanogaster)
Insecta Tob 37
  • 62 (a)
Tob 36
  • 26 (a)
Species with no ortholog for TOB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TOB1 Gene

Gene Tree for TOB1 (if available)
Gene Tree for TOB1 (if available)

Paralogs for TOB1 Gene

Paralogs for TOB1 Gene

(3) SIMAP similar genes for TOB1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TOB1: view

Variants for TOB1 Gene

Sequence variations from dbSNP and Humsavar for TOB1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs3316 - 50,863,062(+) AAGAT(C/T)TCTCA reference, missense
rs4626 -- 50,863,061(-) GAGAA(A/G)TCTTT reference, synonymous-codon
rs1804535 -- 50,863,207(-) CTAAT(G/T)CCAAG reference, missense
rs7221352 -- 50,869,864(+) GGAGT(A/G)GAGGG upstream-variant-2KB
rs9903822 -- 50,869,445(+) TCGCC(A/T)GTAAT upstream-variant-2KB

Variation tolerance for TOB1 Gene

Residual Variation Intolerance Score: 43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TOB1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TOB1 Gene

Disorders for TOB1 Gene

Relevant External Links for TOB1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TOB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TOB1 Gene

Publications for TOB1 Gene

  1. Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity. (PMID: 8632892) Matsuda S. … Yamamoto T. (Oncogene 1996) 2 3 4 23 67
  2. Structural basis for the antiproliferative activity of the Tob-hCaf1 complex. (PMID: 19276069) Horiuchi M. … Inagaki F. (J. Biol. Chem. 2009) 3 23
  3. Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex. (PMID: 18377426) Miyasaka T. … Yamamoto T. (Cancer Sci. 2008) 3 23
  4. Human TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylation. (PMID: 17785442) Ezzeddine N. … Shyu A.B. (Mol. Cell. Biol. 2007) 2 3
  5. Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes. (PMID: 17164348) Tzachanis D. … Boussiotis V.A. (Blood 2007) 3 23

Products for TOB1 Gene

Sources for TOB1 Gene

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