Aliases for TOB1 Gene
External Ids for TOB1 Gene
Previous HGNC Symbols for TOB1 Gene
Previous GeneCards Identifiers for TOB1 Gene
This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
GeneCards Summary for TOB1 Gene
TOB1 (Transducer Of ERBB2, 1) is a Protein Coding gene. Among its related pathways are IL-2 Gene Expression in Activated and Quiescent T-Cells and DREAM Repression and Dynorphin Expression. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity and SMAD binding. An important paralog of this gene is TOB2.
UniProtKB/Swiss-Prot for TOB1 Gene
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:8632892, PubMed:23236473). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257).