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TOB1 Gene

protein-coding   GIFtS: 59
GCID: GC17M048939

Transducer Of ERBB2, 1


(Previous symbol: TROB1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transducer Of ERBB2, 11 2     PIG492
TROB11 2 3     TROB2
TOB2 3 5     Proliferation-Inducing Gene 492
Transducer Of ErbB-2 12 3     Protein Tob12
APRO62     

External Ids:    HGNC: 119791   Entrez Gene: 101402   Ensembl: ENSG000001412327   OMIM: 6055235   UniProtKB: P506163   

Export aliases for TOB1 gene to outside databases

Previous GC identifers: GC17M048653 GC17M051420 GC17M049281 GC17M049414 GC17M046294 GC17M044308


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TOB1 Gene:
This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this
family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may
function as a tumor suppressor. Alternate splicing results in multiple transcript variants. (provided by RefSeq,
Aug 2011)

GeneCards Summary for TOB1 Gene:
TOB1 (transducer of ERBB2, 1) is a protein-coding gene. GO annotations related to this gene include transcription corepressor activity and SMAD binding. An important paralog of this gene is BTG4.

UniProtKB/Swiss-Prot: TOB1_HUMAN, P50616
Function: Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the
CCR4-NOT complex

Gene Wiki entry for TOB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TOB1 gene promoter:
         c-Fos   AP-1   FOXO4   Pax-2   c-Jun   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TOB1 promoter sequence
   Search Chromatin IP Primers for TOB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TOB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21.33

TOB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TOB1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M048939:  view genomic region     (about GC identifiers)

Start:
48,939,584 bp from pter      End:
48,945,339 bp from pter
Size:
5,756 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TOB1_HUMAN, P50616 (See protein sequence)
Recommended Name: Protein Tob1  
Size: 345 amino acids; 38155 Da
Subunit: Interacts with ERBB2. Interacts with CNOT7 and CNOT8
2 PDB 3D structures from and Proteopedia for TOB1:
2D5R (3D)        2Z15 (3D)    
Secondary accessions: B2R9T0 D3DTY3 Q4KMQ0

Explore the universe of human proteins at neXtProt for TOB1: NX_P50616

Explore proteomics data for TOB1 at MOPED

Post-translational modifications: 

  • Phosphorylated on Ser and Thr residues1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TOB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001230806.1  NP_001230814.1  NP_005740.1  

    ENSEMBL proteins: 
     ENSP00000427695   ENSP00000268957  

    TOB1 Human Recombinant Protein Products:

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    Novus Biologicals TOB1 Protein
    Novus Biologicals TOB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TOB1

     
    Search eBioscience for Proteins for TOB1 

     
    antibodies-online proteins for TOB1 (2 products) 

     
    antibodies-online peptides for TOB1

    TOB1 Antibody Products:

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    antibodies-online antibodies for TOB1 (39 products) 

    TOB1 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TOB1
    Cloud-Clone Corp. CLIAs for TOB1
    Search eBioscience for ELISAs for TOB1 
    antibodies-online kits for TOB1 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR015676 Tob
     IPR002087 Anti_prolifrtn

    Graphical View of Domain Structure for InterPro Entry P50616

    ProtoNet protein and cluster: P50616

    1 Blocks protein domain: IPB002087 Anti-proliferative protein

    UniProtKB/Swiss-Prot: TOB1_HUMAN, P50616
    Similarity: Belongs to the BTG family


    Find genes that share domains with TOB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TOB1_HUMAN, P50616
    Function: Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the
    CCR4-NOT complex

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity ----
    GO:0005070SH3/SH2 adaptor activity TAS8632892
    GO:0005515protein binding IPI18377426
    GO:0030971receptor tyrosine kinase binding IDA8632892
    GO:0046332SMAD binding ----
         
    Find genes that share ontologies with TOB1           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tob1):
     cellular  skeleton 

    Find genes that share phenotypes with TOB1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tob1tm1Tya for TOB1

       genOway: Develop your customized and physiologically relevant rodent model for TOB1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TOB1:
    hsa-mir-641 (MIRT039574), hsa-mir-17-5p (MIRT050970), hsa-mir-218-5p (MIRT007049)

    Block miRNA regulation of human, mouse, rat TOB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TOB1 (see all 49):
    hsa-miR-345 hsa-miR-429 hsa-miR-25 hsa-miR-138-2* hsa-miR-218 hsa-miR-374c hsa-miR-186 hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidTOB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TOB1
    Predesigned siRNA for gene silencing in human, mouse, rat TOB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TOB1

    Clone
    Products:
         
    OriGene clones in human, mouse for TOB1 (see all 8)
    OriGene ORF clones in mouse, rat for TOB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TOB1 (NM_005749)
    Sino Biological Human cDNA Clone for TOB1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOB1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TOB1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TOB1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    cytoskeleton1
    extracellular1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0030014CCR4-NOT complex IDA--

    Find genes that share ontologies with TOB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TOB1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1IL-2 Gene Expression in Activated and Quiescent T-Cells
    TOB in T-Cell Signaling0.40
    IL-2 Gene Expression in Activated and Quiescent T-Cells0.40
    2Deadenylation-dependent mRNA decay
    RNA degradation0.48
    3Immune response IL 2 activation and signaling pathway
    Immune response IL 2 activation and signaling pathway0.41
    4Signaling by BMP
    BMP signalling and regulation0.35
    5DREAM Repression and Dynorphin Expression
    TOB in Osteoblast Signaling0.00


    Find genes that share SuperPaths with TOB1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TOB1
        IL-2 Gene Expression in Activated and Quiescent T-Cells
    TOB in T-Cell Signaling
    TOB in Osteoblast Signaling

    1 GeneGo (Thomson Reuters) Pathway for TOB1
        Immune response IL-2 activation and signaling pathway

    2 BioSystems Pathways for TOB1
        Diurnally regulated genes with circadian orthologs
    BMP signalling and regulation



    1 Kegg Pathway  (Kegg details for TOB1):
        RNA degradation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TOB1
    Interactions:

        GeneGlobe Interaction Network for TOB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TOB1 (P506161, 2, 3 ENSP000002689574) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CPEB3Q8NE351, 2, 3, ENSP000002659974EBI-723281,EBI-8596191 MINT-8176462 MINT-8176507 MINT-8176406 MINT-8176523 MINT-8173967 MINT-8176376 MINT-8176426 MINT-8176476 I2D: score=1 STRING: ENSP00000265997
    CNOT1A5YKK61, 3, ENSP000003209494STRING: ENSP00000320949 EBI-723281,EBI-1222758 I2D: score=1 
    CNOT3O751751, 3, ENSP000002212324EBI-723281,EBI-743073 I2D: score=1 STRING: ENSP00000221232
    CNOT6LQ96LI51, 3, ENSP000002649034EBI-723281,EBI-1046635 I2D: score=1 STRING: ENSP00000264903
    PABPC1P119401, 3, ENSP000003130074EBI-723281,EBI-81531 I2D: score=1 STRING: ENSP00000313007
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007184SMAD protein import into nucleus ----
    GO:0008285negative regulation of cell proliferation IDA19276069
    GO:0009967positive regulation of signal transduction TAS8632892
    GO:0017148negative regulation of translation IDA--
    GO:0030514negative regulation of BMP signaling pathway ----

    Find genes that share ontologies with TOB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TOB1

    3 Novoseek inferred chemical compound relationships for TOB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    proline 24.1 1 8632892 (1)
    glutamine 18 1 8632892 (1)
    tyrosine 5.41 2 11260258 (1)



    Find genes that share compounds with TOB1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TOB1 gene (3 alternative transcripts): 
    NM_001243877.1  NM_001243885.1  NM_005749.3  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000499247(uc021uac.1 uc002isw.3 uc010wmz.2) ENST00000268957
    ENST00000509385
    miRNA
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    Block miRNA regulation of human, mouse, rat TOB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TOB1 (see all 49):
    hsa-miR-345 hsa-miR-429 hsa-miR-25 hsa-miR-138-2* hsa-miR-218 hsa-miR-374c hsa-miR-186 hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidTOB1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TOB1
    Clone
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    OriGene ORF clones in mouse, rat for TOB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TOB1 (NM_005749)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TOB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TOB1
    Primer
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    OriGene qPCR primer pairs and template standards for TOB1
    OriGene qSTAR qPCR primer pairs in human, mouse for TOB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TOB1
      QuantiTect SYBR Green Assays in human, mouse, rat TOB1
      QuantiFast Probe-based Assays in human, mouse, rat TOB1

    Selected AceView cDNA sequences (see all 205):

    AW189175 AA972087 AA675892 BU581175 BU683928 AA452505 AI471670 AA630691 
    AI376248 AA258382 AI245035 AI634619 AI597828 AW338711 AW518019 CA453929 
    AI648668 AA454090 AW268878 AA429424 BF059277 AI792252 AW070568 CB163771 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TOB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAGAGGGA
    TOB1 Expression
    About this image


    TOB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             T Helper Cells Thymus
             Bone marrow-derived hematopoietic stem cells (family)
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Paraxial Mesoderm Cells Branchial Arch 1
     
     Head Mesenchyme (Muscoskeletal System)
             Paraxial Mesoderm Cells Branchial Arch 1
    TOB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TOB1 Protein Expression

    UniProtKB/Swiss-Prot: TOB1_HUMAN, P50616
    Tissue specificity: Ubiquitous

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    QuantiFast Probe-based Assays in human, mouse, rat TOB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TOB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TOB1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tob11 , 5 transducer of ErbB-2.11, 5 91.01(n)1
    94.78(a)1
      11 (58.90 cM)5
    220571  NM_009427.21  NP_033453.21 
     942114545 
    chicken
    (Gallus gallus)
    Aves TOB11 transducer of ERBB2, 1 90.77(n)
    97.23(a)
      395225  NM_001001467.1  NP_001001467.1 
    lizard
    (Anolis carolinensis)
    Reptilia TOB16
    transducer of ERBB2, 1
    94(a)
    1 ↔ 1
    2(117453808-117454806)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684572 hypothetical protein MGC68457 77.66(n)    BC060329.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tob12 transducer of ERBB2, 1 85.13(n)   386629  BC056290.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tob3 negative regulation of cell
    proliferation
    62(a)   14A8   --


    ENSEMBL Gene Tree for TOB1 (if available)
    TreeFam Gene Tree for TOB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for TOB1 gene
    BTG42  TOB22  BTG12  BTG32  BTG22  
    3 SIMAP similar genes for TOB1 using alignment to 1 protein entry:     TOB1_HUMAN:
    TOB2    BTG1    BTG2

    Find genes that share paralogs with TOB1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TOB1 (see all 91)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs781270361,2
    F--48939209(+) TCTCTC/GCATAT 3 -- int1 ds50011Minor allele frequency- G:0.01WA 118
    rs1474717311,2
    --48939368(+) GGGCTA/GTTAAA 3 -- int1 ds50010--------
    rs1399763041,2
    --48939439(+) AACCAC/TGATCT 3 -- int1 ds50010--------
    rs93035681,2
    C,F,A,H--48939527(+) TACAAC/TATAAT 3 -- int1 ds500131Minor allele frequency- T:0.33NS EA NA WA CSA 2953
    rs1828048151,2
    --48939578(+) GACAAC/TAGGCA 3 -- int1 ds50010--------
    rs1439368821,2
    --48939862(+) TAGTTC/GATGTC 3 -- ut310--------
    rs1861434801,2
    --48940061(+) TTATTA/GGTGCC 3 -- ut310--------
    rs561061591,2
    C--48940257(+) AGCTT-/AAAAAA 3 -- ut310--------
    rs46261,2
    C,F,O,A,H--48940422(-) GAGAAG/ATCTTT 6 /K syn148Minor allele frequency- A:0.33MN NS EA NA WA CSA EU 9939
    rs33161,2,,4
    C,H--48940423(+) AAGATT/CTCTCA 6 /K /R mis19Minor allele frequency- C:0.04MN NS EA NA 670

    HapMap Linkage Disequilibrium report for TOB1 (48939584 - 48945339 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TOB1: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TOB1
    DNA2.0 Custom Variant and Variant Library Synthesis for TOB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605523    OMIM disorders: --


    Find genes that share disorders with TOB1           About GenesLikeMe

    3 Novoseek inferred disease relationships for TOB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 4.09 4 14643028 (2), 16445768 (1)
    tumors 0 6 14643028 (2), 15766599 (1), 18657378 (1), 12756225 (1)
    cancer 0 9 14643028 (2), 12756225 (2), 18657378 (1)

    Genetic Association Database (GAD): TOB1
    Human Genome Epidemiology (HuGE) Navigator: TOB1 (2 documents)

    Export disorders for TOB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TOB1 gene, integrated from 10 sources (see all 69):
    (articles sorted by number of sources associating them with TOB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity. (PubMed id 8632892)1, 2, 3, 9 Matsuda S.... Yamamoto T. (Oncogene 1996)
    2. Structural basis for the antiproliferative activity of the Tob-hCaf1 complex. (PubMed id 19276069)1, 2, 9 Horiuchi M.... Inagaki F. (J. Biol. Chem. 2009)
    3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    4. Human TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylation. (PubMed id 17785442)1, 3 Ezzeddine N....Shyu A.B. (Mol. Cell. Biol. 2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Regulation of subcellular localization of the antiproliferative protein Tob by its nuclear export signal and bipartite nuclear localization signal sequences. (PubMed id 15051490)1, 9 Maekawa M....Nishida E. (Exp. Cell Res. 2004)
    7. Alteration of expression or phosphorylation status of tob, a novel tumor suppressor gene product, is an early event in lung cancer. (PubMed id 14643028)1, 9 Iwanaga K....Sueoka E. (Cancer Lett. 2003)
    8. Identification of the Anti-proliferative protein Tob as a MAPK substrate. (PubMed id 12151396)1, 9 Maekawa M....Tanoue T. (J. Biol. Chem. 2002)
    9. A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob. (PubMed id 11260258)1, 9 Suzuki T....Yamamoto T. (amp 2001)
    10. Interaction of anti-proliferative protein Tob with poly(A)-binding protein and inducible poly(A)-binding protein: implication of Tob in translational control. (PubMed id 15676026)1, 9 Okochi K....Yamamoto T. (amp 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10140 HGNC: 11979 AceView: TOB1 Ensembl:ENSG00000141232 euGenes: HUgn10140
    ECgene: TOB1 Kegg: 10140 H-InvDB: TOB1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TOB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TOB1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TOB1 gene:
    Search GeneIP for patents involving TOB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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