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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TNXB Gene

protein-coding GIFtS: 61
GCID: GC06M032008

tenascin XB

(Previous symbols: TNXB1, TNXB2)

Explore 39 diseases affiliated with
TNXB via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tenascin XB¹ ²		HXBL² ³
TNXB1¹ ² ³ ⁵		TN-X² ³
TNXB2¹ ² ³ ⁵		EDS3²
XB¹ ² ³		TENX²
TNXBS¹ ² ⁵		Growth-Inhibiting Protein 45²
TNX² ³ ⁵		Tenascin XB1²
XBS¹ ²		Tenascin XB2²
Hexabrachion-Like Protein² ³		Tenascin-X¹

External Ids:	HGNC: 11976¹	Entrez Gene: 7148²	Ensembl: ENSG00000168477⁷	OMIM: 600985⁵	UniProtKB: P22105³

Export aliases for TNXB gene to outside databases

Previous GC identifers: GC06M032037 GC06M031779 GC06M032080 GC06M032085 GC06M032116 GC06M032087 GC06M032089 GC06M032091 GC06M032093 GC06M032095 GC06M032097 GC06M031976

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNXB:

This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have

anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix

maturation during wound healing, and its deficiency has been associated with the connective tissue disorder

Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on

chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is

incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is

unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript

variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TENX_HUMAN, P22105

Function: Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that

appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of

epithelial tumors

Gene Wiki entry for TNXB (Tenascin X)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NT_007592.15 NT_113891.2 NT_167244.1 NT_167245.1 NT_167246.1 NT_167247.1 NT_167248.1

NT_167249.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TNXB gene promoter:
AP-1 Sp1 Bach2 HOXA5 COMP1 Lmo2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TNXB promoter sequence

Search SABiosciences Chromatin IP Primers for TNXB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNXB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.3

TNXB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNXB gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M032008: view genomic region (about GC identifiers)

Start:	32,008,931 bp from pter	End:	32,083,111 bp from pter
Size:	74,181 bases	Orientation:	minus strand

6/7 alternative locations (see all 7):

Chr6-,ALT_REF_LOCI_1 32,052,787-32,073,546	Chr6-,ALT_REF_LOCI_2 31,957,379-32,064,799	Chr6-,ALT_REF_LOCI_3 31,984,751-32,063,968
Chr6-,ALT_REF_LOCI_5 32,000,196-32,068,404	Chr6-,ALT_REF_LOCI_4 31,995,078-32,028,488	Chr6-,ALT_REF_LOCI_6 31,966,588-32,047,111

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TENX_HUMAN, P22105 (See protein sequence)

Recommended Name: Tenascin-X precursor

Size: 4289 amino acids; 464325 Da

Subunit: Homotrimer. Interacts with type I, III and V collagens and tropoelastin via its 29th fibronectin type-III

domain

Subcellular location: Secreted, extracellular space, extracellular matrix

Developmental stage: Expression levels are lower in adults than in children

Caution: There are two genes for TN-X: TNXA and TNXB. TNXA is a partial gene which can sometimes recombine with TNXB

Sequence caution: Sequence=AAH33740.1; Type=Erroneous initiation; Sequence=CAB89296.1; Type=Erroneous initiation;

Sequence=CAI17414.1; Type=Erroneous gene model prediction; Sequence=CAI17471.1; Type=Erroneous gene model prediction;

Sequence=CAI18078.1; Type=Erroneous gene model prediction; Sequence=CAI18332.1; Type=Erroneous gene model prediction;

Sequence=CAQ09268.1; Type=Erroneous gene model prediction;

3 PDB 3D structures from and Proteopedia for TNXB:

2CUH (3D)

2CUI (3D)

2CUM (3D)

Secondary accessions: P78530 P78531 Q08424 Q08AM0 Q08AM1 Q59GU7 Q5SQD3 Q5ST74 Q7L8Q4 Q8N4R1 Q9NPK9

Q9UC10 Q9UC11 Q9UC12 Q9UC13 Q9UMG7

Alternative splicing: 3 isoforms: P22105-1 P22105-2 P22105-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TNXB: NX_P22105

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P22105

TNXB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_061978.6 NP_115859.2

ENSEMBL proteins:

ENSP00000364393 ENSP00000407685 ENSP00000418248 ENSP00000389946 ENSP00000364396

Human Recombinant Protein Products for TNXB:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for TNXB (Tenascin XB2)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: TNXB OriGene Custom Protein Services for TNXB
	GenScript Custom Purified and Recombinant Proteins Services for TNXB
	Novus Biologicals TNXB Protein Novus Biologicals TNXB Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TNXB

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	--	--
GO:0005578	proteinaceous extracellular matrix	NAS	7686164
GO:0005583	colocalizes with fibrillar collagen	IDA	16278880
GO:0005615	extracellular space	IDA	--
GO:0005622	intracellular	IDA	15102077

TNXB for ontologies About GeneDecksing

TNXB Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for TNXB (Tenascin XB2, Tenascin X)
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	GenScript Custom Superior Antibodies Services for TNXB
	Novus Biologicals TNXB Antibodies
	Abcam antibodies for TNXB
	Uscn Antibodies for TNXB
	Search ThermoFisher Antibodies for TNXB

Assay Products for TNXB:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TNXB
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TNXB

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TNXB for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR020837 Fibrinogen_CS

IPR000742 EG-like_dom

IPR003961 Fibronectin_type3

IPR013032 EGF-like_CS

IPR014715 Fibrinogen_a/b/g_C_2

Graphical View of Domain Structure for InterPro Entry P22105

ProtoNet protein and cluster: P22105

3 Blocks protein families:

IPB002049 Laminin-type EGF-like domain

IPB002181 Fibrinogen

IPB006210 Type I EGF

UniProtKB/Swiss-Prot: TENX_HUMAN, P22105

Similarity: Belongs to the tenascin family

Similarity: Contains 19 EGF-like domains

Similarity: Contains 1 fibrinogen C-terminal domain

Similarity: Contains 32 fibronectin type-III domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TENX_HUMAN, P22105

Function: Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that

appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of

epithelial tumors

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	--	--
GO:0005178	integrin binding	ISS	--
GO:0005518	collagen binding	IEA	--
GO:0008201	heparin binding	ISS	--

TNXB for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for TNXB:

Synthetic lethal with Ras

3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Tnxb):

integument

mortality/aging

tumorigenesis

TNXB for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Tnxb^tm1Kmat for TNXB

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TNXB

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TNXB Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNXB
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate TNXB (see all 13):
		hsa-miR-30c hsa-miR-3607-3p hsa-miR-137 hsa-miR-148b hsa-miR-30d hsa-miR-152 hsa-miR-942 hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: TNXB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNXB (see all 4) OriGene shRNA RFP: TNXB OriGene siRNA: TNXB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNXB
		Sirion Biotech Custom design and validation of potent shRNA sequences against TNXB

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TNXB
			Sirion Biotech Customized adenovirus for potent knockdown of TNXB

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNXB (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNXB (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TNXB (NM_019105)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNXB
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TNXB

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TNXB
		Search LifeMap BioReagents cell lines for TNXB
		Sirion Biotech Customized stable knockdown cell line services for TNXB Sirion Biotech Customized inducible knockdown cell line services for TNXB

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNXB

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Focal Adhesion

Focal Adhesion

1.00

Focal adhesion

0.66

ECM-receptor interaction

ECM-receptor interaction

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for TNXB

Focal Adhesion

2 Kegg Pathways (Kegg details for TNXB):

	Focal adhesion
	ECM-receptor interaction

TNXB for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TNXB

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

4 Interacting proteins for TNXB (P22105^{2, 3} ENSP00000364396⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
VEGFB	P49765³, ENSP00000311127⁴	I2D: score=1 STRING: ENSP00000311127
VEGFA	P15692³, ENSP00000361125⁴	I2D: score=1 STRING: ENSP00000361125
BANP	Q8N9N5³	I2D: score=1
--	P0C6Z1²	MINT-6770484

About this table

Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	--	--
GO:0006631	fatty acid metabolic process	IEA	--
GO:0006641	triglyceride metabolic process	IEA	--
GO:0007155	cell adhesion	ISS	--
GO:0007160	cell-matrix adhesion	IEA	--

TNXB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TNXB for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TNXB
4 Novoseek chemical compound relationships for TNXB gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
steroid	42.3	13	7686164 (2), 8614402 (2), 10343159 (1), 10859342 (1) (see all 7)
fibrinogen	21.1	2	9795100 (1), 17033827 (1)
threonine	15.2	1	10859342 (1)
serine	0	1	10859342 (1)

Search CenterWatch for drugs/clinical trials and news about TNXB / TENX

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TNXB gene (2 alternative transcripts):

NM_019105.6 NM_032470.3

Unigene Cluster for TNXB:

Tenascin XB

Hs.485104 [show with all ESTs]

Unigene Representative Sequence: NM_019105

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000375244 ENST00000490077(uc003nzh.1) ENST00000451343(uc003nzg.1)

ENST00000498094 ENST00000479795 ENST00000486148(uc010jts.1) ENST00000442721

ENST00000375247(uc003nzl.2)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TNXB Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNXB
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate TNXB (see all 13):
		hsa-miR-30c hsa-miR-3607-3p hsa-miR-137 hsa-miR-148b hsa-miR-30d hsa-miR-152 hsa-miR-942 hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: TNXB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNXB (see all 4) OriGene shRNA RFP: TNXB OriGene siRNA: TNXB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNXB
		Sirion Biotech Custom design and validation of potent shRNA sequences against TNXB

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNXB (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNXB (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TNXB (NM_019105)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNXB
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TNXB

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNXB Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TNXB
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNXB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNXB

Additional cDNA sequence:

AB209012.1 AK310080.1 BC033740.1 BC071883.1 BC125114.1 BC125115.1 BC130037.1 EU219621.1

M25813.1 U24488.1 U52699.1 U52700.1 X71923.1 X71927.1 Y13782.1 Y17865.1

Y17866.1 Y17867.1 Y17868.1

16 DOTS entries:

DT.446229 DT.91940211 DT.99966274 DT.100726147 DT.91753285 DT.91753287 DT.91949761 DT.95182965

DT.100727968 DT.91753283 DT.91835724 DT.91973904 DT.102830673 DT.121361465 DT.121361964 DT.95161691

24/262 AceView cDNA sequences (see all 262):

BC033740 AL520344 BM904001 AL044866 BP359599 AI637709 Y13782 BM712719

BF081859 BM561229 CD516083 AA713482 BM926447 BC077075 BM691419 BI011356

CB243599 BF245619 NR_001284 BI909316 AA828336 BF917399 NM_019105 BI914329

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TNXB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCTACCACA

About this image

TNXB expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Endocardium

Atrioventricular Node

Atrioventricular Node Cells

Myocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TNXB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNXB

SOURCE GeneReport for Unigene cluster: Hs.485104

UniProtKB/Swiss-Prot: TENX_HUMAN, P22105

Tissue specificity: Highly expressed in fetal adrenal, in fetal testis, fetal smooth, striated and cardiac muscle.

Isoform XB-short is only expressed in the adrenal gland

SABiosciences Custom PCR Arrays for TNXB

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNXB Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TNXB
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNXB

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNXB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TNXB gene from 4/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TNXB⁶	Uncharacterized protein	8(a)	possible ortholog	16(19936-27906)
lizard (Anolis carolinensis)	Reptilia	TNXB⁶	--	10(a)	1 ↔ 1	2(197917150-198018241)
African clawed frog (Xenopus laevis)	Amphibia	Xl.12557²	Xenopus laevis transcribed sequence with weak similarity to protein pirA40701 (H.sapiens) A40701 tenascin-X precursor - human less	71.87(n)		BX846582.1
zebrafish (Danio rerio)	Actinopterygii	Dr.18547²	Transcribed sequence with weak similarity to protein pirA40701 (H.sapiens) A40701 tenascin-X precursor - human less	76.5(n)		BQ419910.1

ENSEMBL Gene Tree for TNXB (if available)
TreeFam Gene Tree for TNXB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TNXB gene

TNR² FIBCD1² FCN3² FCN1² FCN2² TNN² MFAP4² FN1²

TNC² ANGPTL5²

16 SIMAP similar genes for TNXB using alignment to 18 protein entries: TENX_HUMAN (see all proteins):

dJ34F7.1 XB TNXA ANGPTL2 FCN3 FCN1

ANGPTL7 FCN2 MFAP4 ANGPT1 FIBCD1 FGL1

LFIRE1 SNED1 TNR TNC

TNXB for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for TNXB
PGOHUM00000243139 PGOHUM00000260124

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs121912575^1,2	C	pathogenic	31806525(-)	`TGCCCG/ATGGAA`	2	/M /V	mis¹		1		EU	569
rs201649053^1,2	C	other	31778018(+)	`GCACGA/GTGAAG`	2	T I	mis¹		0	--	--	--	--
rs59910551^1,2	F	--	31763847(+)	`GCTCCC/TGTAGA`	4	R G	mis¹		1		NS	72
rs9501600^1,2	F	--	31763913(+)	`GACAGC/TGCAGG`	4	T A	mis¹		1		NS	68
rs4959083^1,2	C,F,A,H	--	31763930(+)	`GCAAGC/TTGTTG`	4	N S	mis¹		3		NA	6
rs4959084^1,2	C,F,A	--	31763940(+)	`GGGGTC/TCCGAT`	4	N D	mis¹		3		NS NA	74
rs11755562^1,2	H	--	31764159(+)	`GCCTCA/GTCCCC`	4	D	syn¹		0	--	--	--	--
rs6941704^1,2	C,F	--	31764181(+)	`CCACGC/TGCATG`	4	H R	mis¹		3		NA	6
rs11965781^1,2	C,F,A,H	--	31764244(+)	`GGATAT/CGTGCC`	2	--	int¹		4		NA	8
rs2072631^1,2	C,F,A,H	--	31764295(-)	`GGGAAC/GTACGG`	2	--	int¹		8		NA WA	142

HapMap Linkage Disequilibrium report for TNXB (32008931 - 32083111 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 15 variations for TNXB
15 CNVs: 0599 36512 36511 31278 36507 3602 0600 69404 32786 32785 36509 69403 64474 59325 36510
Human Gene Mutation Database (HGMD): TNXB

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TNXB for disorders           About GeneDecksing

OMIM gene information: 600985
OMIM disorders: 606408  130020
UniProtKB/Swiss-Prot: TENX_HUMAN, P22105

Defects in TNXB are the cause of tenascin-X deficiency (TNXD) [MIM:606408]. TNXD leads to an

Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility.

Tenascin-X-deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos.

Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients

20/39 diseases for TNXB (see all 39): About MalaCards

ehlers-danlos syndrome ehlers-danlos due to tenascin x deficiency 21-hydroxylase deficiency mitral valve prolapse

connective tissue disease aortic aneurysm hypermobility syndrome abdominal aortic aneurysm

adrenal hyperplasia cervical incompetence juvenile rheumatoid arthritis systemic lupus erythematosus

lupus erythematosus pleomorphic adenoma rheumatoid arthritis malignant mesothelioma

alcoholic cardiomyopathy myocardial infarction hodgkin's lymphoma aneurysm disease

2 diseases from the University of Copenhagen DISEASES database for TNXB:

Ehlers-Danlos syndrome Hypermobility syndrome

10/11 Novoseek disease relationships for TNXB gene (see all 11) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tnx deficiency	94.9	5	19921645 (1), 9288108 (1), 17033827 (1)
ehlers-danlos syndrome	90.7	32	11642233 (4), 11925569 (4), 16278880 (2), 15366699 (2) (see all 20)
ehlers-danlos syndrome, type iii	85.4	3	19921645 (1), 15708907 (1), 15733269 (1)
hypermobility syndrome	68.9	2	15708907 (1), 16601453 (1)
collagen fibril	63.6	5	16278880 (1), 20089348 (1), 16331473 (1), 17033827 (1) (see all 5)
connective tissue diseases	50.2	4	18595676 (1), 15558324 (1), 11925569 (1)
aortic aneurysm abdominal	15	2	16567571 (2)
scar	11.4	5	17453911 (3)
inflammation	0	1	17234708 (1)
glioma	0	2	9144580 (1)

GeneTests: TNXB

Ehlers-Danlos Syndrome, Hypermobility Type

Genetic Association Database (GAD): TNXB
Human Genome Epidemiology (HuGE) Navigator: TNXB (19 documents)

Export disorders for TNXB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TNXB gene, integrated from 9 sources (see all 116):
(articles sorted by number of sources associating them with TNXB)

Utopia: connect your pdf to the dynamic
world of online information

Sequences promoting the transcription of the human XA gene overlapping P450c21A correctly predict the presence of a novel, adrenal-specific, truncated form of tenascin-X. (PubMed id 8530023)^{1, 2, 3, 9} Tee M.K.... Miller W.L. (1995)
Tenascin-X deficiency is associated with Ehlers-Danlos syndrome. (PubMed id 9288108)^{1, 4, 9} Burch G.H....Bristow J. (1997)
Interactions of human tenascin-X domains with dermal extracellular matrix molecules. (PubMed id 17033827)^{1, 2, 9} Egging D....Schalkwijk J. (2007)
A recessive form of the Ehlers-Danlos syndrome caused by tenascin-X deficiency. (PubMed id 11642233)^{1, 2, 9} Schalkwijk J.... Bristow J. (2001)
Identification and characterization of multiple species of tenascin-X in human serum. (PubMed id 17263730)^{1, 2, 9} Egging D.F.... Schalkwijk J. (2007)
Elastic fiber abnormalities in hypermobility type Ehlers-Danlos syndrome patients with tenascin-X mutations. (PubMed id 15733269)^{1, 2, 9} Zweers M.C....Schalkwijk J. (2005)
Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B. (PubMed id 7686164)^{1, 2, 9} Bristow J.... Miller W.L. (1993)
Lack of a genetic association between the TNXB locus and schizophrenia in a Chinese population. (PubMed id 14729256)^{1, 4, 9} Liu L.L....Hemmings G.P. (2004)
Alternate promoters and alternate splicing of human tenascin-X, a gene with 5' and 3' ends buried in other genes. (PubMed id 8923003)^{1, 2, 9} Speek M.... Miller W.L. (1996)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7148	HGNC: 11976	AceView: CREBL1andTNXB	Ensembl:ENSG00000168477	euGenes: HUgn7148
ECgene: TNXB	Kegg: 7148	H-InvDB: TNXB

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TNXB	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TNXB

Intellectual Property for TNXB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TNXB gene:
Search GeneIP for patents involving TNXB

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section


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