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Aliases for TNXA Gene

Aliases for TNXA Gene

  • Tenascin XA (Pseudogene) 2 3 5
  • XA 3 4
  • Tenascin XA Pseudogene 3
  • Tenascin XA 2
  • D6S103E 3
  • TN-XA 4
  • HXBL 3
  • TNX 3

External Ids for TNXA Gene

Previous HGNC Symbols for TNXA Gene

  • TNX

Previous GeneCards Identifiers for TNXA Gene

  • GC06U990124
  • GC06M032084
  • GC06M031977
  • GC06M031979

Summaries for TNXA Gene

GeneCards Summary for TNXA Gene

TNXA (Tenascin XA (Pseudogene)) is a Pseudogene. Diseases associated with TNXA include Ehlers-Danlos Syndrome Due To Tenascin X Deficiency and Vesicoureteral Reflux 8.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNXA Gene

Genomics for TNXA Gene

Regulatory Elements for TNXA Gene

Enhancers for TNXA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TNXA on UCSC Golden Path with GeneCards custom track

Genomic Location for TNXA Gene

32,008,420 bp from pter
32,013,023 bp from pter
4,604 bases
Minus strand

Genomic View for TNXA Gene

Genes around TNXA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNXA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNXA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for TNXA Gene

  • Protein details for TNXA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative tenascin-XA
    Protein Accession:

    Protein attributes for TNXA Gene

    311 amino acids
    Molecular mass:
    33740 Da
    Quaternary structure:
    No Data Available
    • TNX genes are located in the class III HLA region within a complex locus, named RCCX module, containing genes for RP1/STK19, C4B, CYP21B/CYP21A2 and TNXB. Most chromosomes bear 2 modules, but monomodular and trimodular haplotypes are common in most populations. The bimodular haplotype results from the duplication of the RCCX module, leading to a duplicate containing RP2/RP1 pseudogene, C4A, CYP21A/CYP21A1P and TNXA. TNXA is a duplicated section of TNXB and probably consists in a truncated pseudogene: it contains a 120 bp deletion causing a frameshift and a premature stop codon that probably render the gene non-functional. In some pathologies, an unequal crossover between monomodular and bimodular RCCX results in a chromosome with a TNXB-TNXA hybrid gene, arising from a fusion between the TNXB gene of a monomodular RCCX and the TNXA gene of a bimodular RCCX. The TNXB-TNXA hybrid may correspond to TNXB-Short gene and may produce a functional protein.

neXtProt entry for TNXA Gene

Proteomics data for TNXA Gene at MOPED

Post-translational modifications for TNXA Gene

No Post-translational modifications

No data available for DME Specific Peptides for TNXA Gene

Domains & Families for TNXA Gene

Protein Domains for TNXA Gene


Suggested Antigen Peptide Sequences for TNXA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 fibronectin type-III domains.
  • Contains 3 fibronectin type-III domains.
genes like me logo Genes that share domains with TNXA: view

No data available for Gene Families for TNXA Gene

Function for TNXA Gene

Molecular function for TNXA Gene

GENATLAS Biochemistry:
tenascin-like XA,homologous to XBS,included in YA and overlapping CYP21P,both in opposite orientation,(see XA)

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TNXA Gene

Localization for TNXA Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TNXA Gene

Pathways & Interactions for TNXA Gene

SuperPathways for TNXA Gene

No Data Available

Interacting Proteins for TNXA Gene

Gene Ontology (GO) - Biological Process for TNXA Gene


No data available for Pathways by source and SIGNOR curated interactions for TNXA Gene

Drugs & Compounds for TNXA Gene

(17) Drugs for TNXA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(16) Additional Compounds for TNXA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNXA: view

Transcripts for TNXA Gene

mRNA/cDNA for TNXA Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TNXA Gene

Tenascin XA (pseudogene):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNXA Gene

No ASD Table

Relevant External Links for TNXA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNXA Gene

mRNA expression in normal human tissues for TNXA Gene

mRNA differential expression in normal tissues according to GTEx for TNXA Gene

This gene is overexpressed in Adrenal Gland (x37.3).

Protein differential expression in normal tissues from HIPED for TNXA Gene

This gene is overexpressed in Serum (54.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TNXA Gene

SOURCE GeneReport for Unigene cluster for TNXA Gene Hs.708061

mRNA Expression by UniProt/SwissProt for TNXA Gene

Tissue specificity: Expressed in the adrenal gland.
genes like me logo Genes that share expression patterns with TNXA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for TNXA Gene

Orthologs for TNXA Gene

Evolution for TNXA Gene

Gene Tree for TNXA (if available)
Gene Tree for TNXA (if available)

No data available for Orthologs for TNXA Gene

Paralogs for TNXA Gene

(5) SIMAP similar genes for TNXA Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TNXA: view

No data available for Paralogs for TNXA Gene

Variants for TNXA Gene

Sequence variations from dbSNP and Humsavar for TNXA Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs4959087 -- 32,011,083(+) AGGGC(A/G)GCTGG intron-variant
rs9501602 -- 32,011,488(+) TACAA(A/G)GACCC intron-variant
rs11967753 -- 32,011,728(+) AAAGC(C/G)GAGCA nc-transcript-variant
rs12206663 -- 32,011,295(+) AGGAA(C/T)AATGA intron-variant
rs12208559 -- 32,012,223(+) TGTAG(C/G)GGGTG nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for TNXA Gene

Variant ID Type Subtype PubMed ID
dgv1928e1 CNV Complex 17122850
nsv428141 CNV Gain+Loss 18775914
dgv1929e1 CNV Complex 17122850
dgv6604n71 CNV Loss 21882294
nsv284 CNV Loss 15895083
nsv5247 CNV Loss 18451855
dgv6607n71 CNV Loss 21882294
dgv6608n71 CNV Gain 21882294
dgv6610n71 CNV Gain 21882294
dgv6612n71 CNV Loss 21882294
dgv6613n71 CNV Loss 21882294
dgv6614n71 CNV Gain 21882294
dgv6615n71 CNV Gain 21882294
dgv6616n71 CNV Gain+Loss 21882294
esv28110 CNV Gain+Loss 19812545
dgv6617n71 CNV Gain+Loss 21882294
nsv10824 CNV Gain+Loss 18304495
dgv6620n71 CNV Gain 21882294
nsv819957 CNV Loss 19587683
dgv6621n71 CNV Gain 21882294
dgv6622n71 CNV Gain+Loss 21882294
nsv884617 CNV Gain 21882294
dgv20n31 CNV Duplication 19718026
nsv884626 CNV Loss 21882294
nsv884627 CNV Loss 21882294
dgv6623n71 CNV Loss 21882294
dgv6624n71 CNV Loss 21882294
dgv6625n71 CNV Gain 21882294
nsv823507 CNV Loss 20364138
dgv6626n71 CNV Gain+Loss 21882294
dgv6627n71 CNV Gain 21882294
dgv6628n71 CNV Loss 21882294
dgv6629n71 CNV Loss 21882294
nsv884657 CNV Gain 21882294
dgv6630n71 CNV Gain+Loss 21882294
dgv6631n71 CNV Loss 21882294
nsv823508 CNV Gain 20364138
nsv884663 CNV Gain 21882294
nsv884664 CNV Gain 21882294
nsv285 CNV Loss 15895083
esv2731825 CNV Deletion 23290073
nsv884665 CNV Loss 21882294

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for TNXA Gene

Disorders for TNXA Gene

MalaCards: The human disease database

(5) MalaCards diseases for TNXA Gene - From: OMIM, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ehlers-danlos syndrome due to tenascin x deficiency
  • ehlers-danlos-like syndrome due to tenascin-x deficiency
vesicoureteral reflux 8
  • vur8
scott syndrome
  • platelet factor x receptor deficiency
heparin-induced thrombocytopenia
  • hit
budd-chiari syndrome
  • hepatic vein thrombosis
- elite association - COSMIC cancer census association via MalaCards
Search TNXA in MalaCards View complete list of genes associated with diseases

Relevant External Links for TNXA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TNXA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNXA Gene

Publications for TNXA Gene

  1. Genetic basis of tobacco smoking: strong association of a specific major histocompatibility complex haplotype on chromosome 6 with smoking behavior. (PMID: 15339882) FA1st G. … Yu C.Y. (Int. Immunol. 2004) 3 48 67
  2. An unequal crossover between the RCCX modules of the human MHC leading to the presence of a CYP21B gene and a tenascin TNXB/TNXA-RP2 recombinant between C4A and C4B genes in a patient with juvenile rheumatoid arthritis. (PMID: 10343159) Rupert K.L. … Yu C.Y. (Exp. Clin. Immunogenet. 1999) 3 23
  3. The complete exon-intron structure of a human complement component C4A gene. DNA sequences, polymorphism, and linkage to the 21- hydroxylase gene. (PMID: 1988494) Yu C.Y. (J. Immunol. 1991) 2 3
  4. Transcript encoded on the opposite strand of the human steroid 21- hydroxylase/complement component C4 gene locus. (PMID: 2475872) Morel Y. … Miller W.L. (Proc. Natl. Acad. Sci. U.S.A. 1989) 2 3
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3

Products for TNXA Gene

Sources for TNXA Gene