TNS4 Gene
protein-coding GIFtS: 51
GCID: GC17M038632
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|
tensin 4
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Aliases for TNS4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Tensin 41 2 | | CTEN1 2 3 5 | | C-Terminal Tensin-Like Protein2 3 | | C Terminal Tensin Like2 | | Tensin-41 |
Export aliases for TNS4 gene to outside databasesPrevious GC identifers: GC17M035886 GC17M034425 |
Summaries for TNS4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: TENS4_HUMAN, Q8IZW8Function: May be involved in cell migration, cartilage development and in linking signal transduction pathways to thecytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3 Gene Wiki entry for TNS4
|
Genomic Views for TNS4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TNS4 gene promoter: Bach1 GR GR-beta Meis-1b Roaz AREB6 IRF-7A GR-alpha Meis-1a Meis-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for TNS4
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNS4 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.2 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q21.2TNS4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M038632: view genomic region
(about GC identifiers)
Start:
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38,632,080 bp from pter |
End:
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38,657,854 bp from pter |
Size:
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25,775 bases |
Orientation:
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minus strand |
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Proteins for TNS4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: TENS4_HUMAN, Q8IZW8 (See
protein sequence)Recommended Name: Tensin-4 precursor Size: 715 amino acids; 76764 Da
Subunit: Binds to actin filaments and interacts with phosphotyrosine-containing proteins (By similarity)
Subcellular location: Cell junction, focal adhesion. Cytoplasm, cytoskeleton
Sequence caution: Sequence=AAQ15257.1; Type=Frameshift; Positions=85, 296, 472, 602;
Secondary accessions: A6NMJ7 Q71RB7 Q8WV64 Q96JV4Explore the universe of human proteins at neXtProt for TNS4: NX_Q8IZW8
Post-translational modifications:
Proteolytically cleaved by caspase-3 during apoptosis1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IZW8 TNS4 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins: NP_116254.4 ENSEMBL proteins: ENSP00000254051 ENSP00000463456 Human Recombinant Protein Products for TNS4:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TNS4 for ontologies About GeneDecksing
TNS4 Antibody Products: Assay Products for TNS4: |
Protein
Domains / Families for TNS4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TNS4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IZW8ProtoNet protein and cluster: Q8IZW8 2 Blocks protein families: IPB000980 SH2 domain signature IPB013625 Tensin phosphotyrosine-binding domain
UniProtKB/Swiss-Prot: TENS4_HUMAN, Q8IZW8Similarity: Contains 1 phosphatase tensin-type domainSimilarity: Contains 1 SH2 domain |
Function for TNS4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: TENS4_HUMAN, Q8IZW8Function: May be involved in cell migration, cartilage development and in linking signal transduction pathways to thecytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3 Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
TNS4 for ontologies About GeneDecksing
Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNS4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNS4 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TNS4 (NM_032865) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TNS4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNS4  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNS4 |
|
Pathways & Interactions for TNS4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TNS4
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
 4 Interacting proteins for TNS4 (Q8IZW82, 3 ENSP000002540514) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
TNS4 for ontologies About GeneDecksing
|
Drugs & Compounds for TNS4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for TNS4 Search CenterWatch for drugs/clinical trials and news about TNS4 / TENS4 
|
Transcripts for TNS4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for TNS4 gene: NM_032865.5 Unigene Cluster for TNS4: Tensin 4 Hs.438292 [show with all ESTs]Unigene Representative Sequence: AF3704214 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000394072(uc002huu.4) ENST00000254051(uc010cxb.3) ENST00000582747 ENST00000497303
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNS4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNS4 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TNS4 (NM_032865) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TNS4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNS4  |
Additional cDNA sequence: AF370421.1 AF417488.1 AK027856.1 BC013373.2 BC018706.1 9 DOTS entries: DT.95292548 DT.100781354 DT.100009947 DT.100741944 DT.91706356 DT.92053909 DT.91668363 DT.92418153 DT.97771696 24/122 AceView cDNA sequences (see all 122): BM909790 BE607411 AI831401 BM908322 AW272596 BM557866 BQ684844 BF001857 BU607467 BF988894 AA368182 BU754258 BQ949444 BQ934801 BC018706 BQ026124 BU169026 CA314003 AW272595 BU679164 BQ023894 BF870437 CB850856 BQ941312 GeneLoc Exon Structure
|
Expression for TNS4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TNS4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AAAAATAAAA
 About this image See TNS4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TNS4
SOURCE GeneReport for Unigene cluster: Hs.438292
UniProtKB/Swiss-Prot: TENS4_HUMAN, Q8IZW8Tissue specificity: Prostate and placenta. Down regulated in prostate cancer SABiosciences Custom PCR Arrays for TNS4
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNS4 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TNS4 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNS4 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNS4 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNS4 |
Orthologs for TNS4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TNS4 gene from 7/23 species (see all 23) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
lizard (Anolis carolinensis) |
Reptilia |
TNS46TNS36 |
-- |
33(a)31(a) |
1 ↔ 1possible ortholog |
6(70224833-70246169) 6(53927804-53939399) |
African clawed frog (Xenopus laevis) |
Amphibia |
Xl.260262 |
Xenopus laevis transcribed sequence with weak similarity more |
74.48(n) |
  |
CD100815.1 |
zebrafish (Danio rerio) |
Actinopterygii |
CABZ01092286.16 |
-- |
32(a) |
1 ↔ 1 |
2(23916-32332) |
fruit fly (Drosophila melanogaster) |
Insecta |
by6 |
blistery |
21(a) |
1 ↔ 1 |
3R(5353960-5358734) |
worm (Caenorhabditis elegans) |
Secernentea |
tag-1636 |
Temporarily Assigned Gene name family member (tag-... |
14(a) |
1 ↔ 1 |
I(5583408-5597335) |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
PEN36PEN26 |
phosphatidylinositol-3,4,5-trisphosphate 3-phospha...phosphatidylinositol-3,4,5-trisphosphate 3-phospha... |
5(a)5(a) |
possible orthologpossible ortholog |
3(18580609-18584535) 3(6731376-6735623) |
rice (Oryza sativa) |
Liliopsida |
-- |
PTEN, putative, expressed |
5(a) |
possible ortholog |
12(12318999-12327551) |
ENSEMBL Gene Tree for TNS4 (if available) TreeFam Gene Tree for TNS4 (if available)  |
Paralogs for TNS4 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for TNS4 gene
- TNS12 DNAJC62 PTEN2 TPTE2 TNS32 TENC12 GAK2 TPTE22
5 SIMAP similar genes for TNS4 using alignment to 5 protein entries: TENS4_HUMAN (see all proteins):DKFZp434G162 DKFZp434I2435 TNS1 TNS3 TENC1
TNS4 for paralogs About GeneDecksing
|
Genomic Variants for TNS4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 17 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for TNS4 (38632080 - 38657854 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TNS4: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNS4 |
|
Disorders
/ Diseases for TNS4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TNS4 for disorders About GeneDecksing
OMIM gene information: 608385
OMIM disorders: --
11 diseases for TNS4: About MalaCardsthymoma kidney cancer liver cancer colon cancer gastric cancer breast carcinoma colorectal cancer lung cancer prostate cancer prostatitis carcinoma
2 Novoseek disease relationships for TNS4 gene About this table
Human Genome Epidemiology (HuGE) Navigator: TNS4 (3 documents) Export disorders for TNS4 gene to outside databases
|
Publications for TNS4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TNS4 gene, integrated from 9 sources (see all 31): (articles sorted by number of sources associating them with TNS4) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Cten, a COOH-terminal tensin-like protein with prostate restricted expression, is down-regulated in prostate cancer. (PubMed id 12154022)1, 2, 3, 9 Lo S.H. and Lo T.B. (2002)
- Cleavage of cten by caspase-3 during apoptosis. (PubMed id 15806167)1, 2, 9 Lo S.-S.... Lo S.H. (2005)
- Cten mRNA expression was correlated with tumor progression in lung cancers. (PubMed id 12711115)1, 3, 9 Sasaki H....Fujii Y. (2003)
- Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- CTEN/tensin 4 expression induces sensitivity to pacli taxel in prostate cancer. (PubMed id 19725034)1, 9 Li Y....Namiki M. (2010)
- Up-regulation of C-terminal tensin-like molecule prom otes the tumorigenicity of colon cancer through beta-catenin. (PubMed id 19487278)1, 9 Liao Y.C....Lo S.H. (2009)
- The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1. (PubMed id 17190795)1, 9 Liao Y.C....Lo S.H. (2007)
- A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration. (PubMed id 17643115)1, 9 Katz M.... Yarden Y. (2007)
|
External Searches for TNS4 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TNS4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TNS4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TNS4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
|
About This Section
| Patent Information for TNS4 gene: Search GeneIP for patents involving TNS4
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for TNS4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
 | |
 | |
 |
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 | | TNS4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNS4 |
|  |  |  |  | | | Search ThermoFisher Antibodies for TNS4 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNS4 |
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