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Aliases for TNS4 Gene

Aliases for TNS4 Gene

  • Tensin 4 2 3 5
  • C-Terminal Tensin-Like Protein 3 4
  • C Terminal Tensin Like 2 3
  • CTEN 3 4
  • PP14434 3

External Ids for TNS4 Gene

Previous GeneCards Identifiers for TNS4 Gene

  • GC17M035886
  • GC17M038632
  • GC17M034425

Summaries for TNS4 Gene

GeneCards Summary for TNS4 Gene

TNS4 (Tensin 4) is a Protein Coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is TNS1.

UniProtKB/Swiss-Prot for TNS4 Gene

  • May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3.

Gene Wiki entry for TNS4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNS4 Gene

Genomics for TNS4 Gene

Regulatory Elements for TNS4 Gene

Enhancers for TNS4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TNS4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TNS4 Gene

Chromosome:
17
Start:
40,475,828 bp from pter
End:
40,501,681 bp from pter
Size:
25,854 bases
Orientation:
Minus strand

Genomic View for TNS4 Gene

Genes around TNS4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNS4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNS4 Gene

Proteins for TNS4 Gene

  • Protein details for TNS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZW8-TENS4_HUMAN
    Recommended name:
    Tensin-4
    Protein Accession:
    Q8IZW8
    Secondary Accessions:
    • A6NMJ7
    • Q71RB7
    • Q8WV64
    • Q96JV4

    Protein attributes for TNS4 Gene

    Size:
    715 amino acids
    Molecular mass:
    76764 Da
    Quaternary structure:
    • Binds to actin filaments and interacts with phosphotyrosine-containing proteins.
    SequenceCaution:
    • Sequence=AAQ15257.1; Type=Frameshift; Positions=85, 296, 472, 602; Evidence={ECO:0000305};

neXtProt entry for TNS4 Gene

Proteomics data for TNS4 Gene at MOPED

Post-translational modifications for TNS4 Gene

Other Protein References for TNS4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for TNS4

No data available for DME Specific Peptides for TNS4 Gene

Domains & Families for TNS4 Gene

Gene Families for TNS4 Gene

Protein Domains for TNS4 Gene

Suggested Antigen Peptide Sequences for TNS4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IZW8

UniProtKB/Swiss-Prot:

TENS4_HUMAN :
  • Contains 1 phosphatase tensin-type domain.
Domain:
  • Contains 1 phosphatase tensin-type domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with TNS4: view

Function for TNS4 Gene

Molecular function for TNS4 Gene

UniProtKB/Swiss-Prot Function:
May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3.

Gene Ontology (GO) - Molecular Function for TNS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with TNS4: view
genes like me logo Genes that share phenotypes with TNS4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNS4 Gene

Localization for TNS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNS4 Gene

Cell junction, focal adhesion. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNS4 Gene COMPARTMENTS Subcellular localization image for TNS4 gene
Compartment Confidence
cytoskeleton 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TNS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with TNS4: view

Pathways & Interactions for TNS4 Gene

SuperPathways for TNS4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TNS4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TNS4 Gene

Drugs & Compounds for TNS4 Gene

No Compound Related Data Available

Transcripts for TNS4 Gene

Unigene Clusters for TNS4 Gene

Tensin 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNS4 Gene

No ASD Table

Relevant External Links for TNS4 Gene

GeneLoc Exon Structure for
TNS4
ECgene alternative splicing isoforms for
TNS4

Expression for TNS4 Gene

mRNA expression in normal human tissues for TNS4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNS4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x15.2), Skin - Sun Exposed (Lower leg) (x13.9), Vagina (x5.2), and Minor Salivary Gland (x5.0).

Protein differential expression in normal tissues from HIPED for TNS4 Gene

This gene is overexpressed in Plasma (49.5) and Placenta (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNS4 Gene



SOURCE GeneReport for Unigene cluster for TNS4 Gene Hs.438292

mRNA Expression by UniProt/SwissProt for TNS4 Gene

Q8IZW8-TENS4_HUMAN
Tissue specificity: Prostate and placenta. Down regulated in prostate cancer.
genes like me logo Genes that share expression patterns with TNS4: view

Protein tissue co-expression partners for TNS4 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for TNS4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNS4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TNS4 35
  • 85.99 (n)
  • 81.79 (a)
TNS4 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNS4 35
  • 86.76 (n)
  • 83.5 (a)
TNS4 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tns4 35
  • 81.36 (n)
  • 77.23 (a)
Tns4 16
Tns4 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TNS4 35
  • 99.54 (n)
  • 98.97 (a)
TNS4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tns4 35
  • 80.45 (n)
  • 75.22 (a)
oppossum
(Monodelphis domestica)
Mammalia TNS4 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNS4 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNS4 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNS4 36
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tns4 35
  • 53.22 (n)
  • 44.88 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26026 35
fruit fly
(Drosophila melanogaster)
Insecta by 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-163 36
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
OneToMany
Species with no ortholog for TNS4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TNS4 Gene

ENSEMBL:
Gene Tree for TNS4 (if available)
TreeFam:
Gene Tree for TNS4 (if available)

Paralogs for TNS4 Gene

Paralogs for TNS4 Gene

(5) SIMAP similar genes for TNS4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TNS4: view

Variants for TNS4 Gene

Sequence variations from dbSNP and Humsavar for TNS4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs3764424 - 40,488,873(+) TGCGA(A/G)GGGAG reference, missense
rs2290207 - 40,484,492(-) TCAGA(A/G/T)TCGAC reference, missense
VAR_036515 A colorectal cancer sample
rs33923045 - 40,487,344(+) GTCTT(G/T)TACAC reference, missense
rs475298 -- 40,498,540(-) gggtg(C/T)agtac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNS4 Gene

Variant ID Type Subtype PubMed ID
nsv833445 CNV Loss 17160897
nsv908224 CNV Gain 21882294

Variation tolerance for TNS4 Gene

Residual Variation Intolerance Score: 49.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.18; 90.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNS4 Gene

HapMap Linkage Disequilibrium report
TNS4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNS4 Gene

Disorders for TNS4 Gene

Relevant External Links for TNS4

Genetic Association Database (GAD)
TNS4
Human Genome Epidemiology (HuGE) Navigator
TNS4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNS4

No disorders were found for TNS4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNS4 Gene

Publications for TNS4 Gene

  1. Cten, a COOH-terminal tensin-like protein with prostate restricted expression, is down-regulated in prostate cancer. (PMID: 12154022) Lo S.H. … Lo T.B. (Cancer Res. 2002) 2 3 4 23 67
  2. Cten mRNA expression was correlated with tumor progression in lung cancers. (PMID: 12711115) Sasaki H. … Fujii Y. (Lung Cancer 2003) 2 3 23
  3. CTEN/tensin 4 expression induces sensitivity to paclitaxel in prostate cancer. (PMID: 19725034) Li Y. … Namiki M. (Prostate 2010) 3 23
  4. Up-regulation of C-terminal tensin-like molecule promotes the tumorigenicity of colon cancer through beta-catenin. (PMID: 19487278) Liao Y.C. … Lo S.H. (Cancer Res. 2009) 3 23
  5. The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1. (PMID: 17190795) Liao Y.C. … Lo S.H. (J. Cell Biol. 2007) 3 23

Products for TNS4 Gene

Sources for TNS4 Gene

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