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TNS4 Gene

protein-coding   GIFtS: 56
GCID: GC17M038632

Tensin 4

  See TNS4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tensin 41 2
CTEN2 3 5
C Terminal Tensin Like1 2
C-Terminal Tensin-Like Protein2 3
tensin-42

External Ids:    HGNC: 243521   Entrez Gene: 849512   Ensembl: ENSG000001317467   OMIM: 6083855   UniProtKB: Q8IZW83   

Export aliases for TNS4 gene to outside databases

Previous GC identifers: GC17M035886 GC17M034425


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TNS4 Gene:
TNS4 (tensin 4) is a protein-coding gene. Diseases associated with TNS4 include kidney cancer. GO annotations related to this gene include actin binding. An important paralog of this gene is DNAJC6.

UniProtKB/Swiss-Prot: TENS4_HUMAN, Q8IZW8
Function: May be involved in cell migration, cartilage development and in linking signal transduction pathways to
the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3

Gene Wiki entry for TNS4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNS4 gene promoter:
         Bach1   GR   GR-beta   Meis-1b   Roaz   AREB6   IRF-7A   GR-alpha   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNS4 promoter sequence
   Search Chromatin IP Primers for TNS4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNS4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

TNS4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNS4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M038632:  view genomic region     (about GC identifiers)

Start:
38,632,080 bp from pter      End:
38,657,854 bp from pter
Size:
25,775 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TENS4_HUMAN, Q8IZW8 (See protein sequence)
Recommended Name: Tensin-4 precursor  
Size: 715 amino acids; 76764 Da
Subunit: Binds to actin filaments and interacts with phosphotyrosine-containing proteins (By similarity)
Sequence caution: Sequence=AAQ15257.1; Type=Frameshift; Positions=85, 296, 472, 602;
Secondary accessions: A6NMJ7 Q71RB7 Q8WV64 Q96JV4

Explore the universe of human proteins at neXtProt for TNS4: NX_Q8IZW8

Explore proteomics data for TNS4 at MOPED

Post-translational modifications: 

  • Proteolytically cleaved by caspase-3 during apoptosis1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TNS4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_116254.4  
    ENSEMBL proteins: 
     ENSP00000254051   ENSP00000463456  

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    Cloud-Clone Corp. Proteins for TNS4

     
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    antibodies-online proteins for TNS4 (4 products) 

     
    antibodies-online peptides for TNS4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    3 InterPro protein domains:
     IPR013625 PTB
     IPR000980 SH2
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q8IZW8

    ProtoNet protein and cluster: Q8IZW8

    2 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB013625 Tensin phosphotyrosine-binding domain


    UniProtKB/Swiss-Prot: TENS4_HUMAN, Q8IZW8
    Similarity: Contains 1 phosphatase tensin-type domain
    Similarity: Contains 1 SH2 domain


    Find genes that share domains with TNS4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TENS4_HUMAN, Q8IZW8
    Function: May be involved in cell migration, cartilage development and in linking signal transduction pathways to
    the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI17190795
         
    Find genes that share ontologies with TNS4           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TNS4

    miRNA
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    miRTarBase miRNAs that target TNS4:
    hsa-mir-335-5p (MIRT018760), hsa-mir-26b-5p (MIRT030073), hsa-mir-124-3p (MIRT023010), hsa-mir-1 (MIRT003769)

    Block miRNA regulation of human, mouse, rat TNS4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNS4 (see all 9):
    hsa-miR-588 hsa-miR-526b hsa-miR-548s hsa-miR-3926 hsa-miR-670 hsa-miR-654-5p hsa-miR-1827 hsa-miR-1207-5p
    SwitchGear 3'UTR luciferase reporter plasmidTNS4 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TENS4_HUMAN, Q8IZW8: Cell junction, focal adhesion. Cytoplasm, cytoskeleton
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol2
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0005925focal adhesion IDA17190795

    Find genes that share ontologies with TNS4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TNS4
    Interactions:

        Search GeneGlobe Interaction Network for TNS4

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for TNS4 (Q8IZW82, 3 ENSP000002540514) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319472, 3MINT-3974963 I2D: score=2 
    ERBB3P218602, 3, ENSP000002671014MINT-74507 I2D: score=1 STRING: ENSP00000267101
    EGFRP005332, 3, ENSP000002754934MINT-74506 I2D: score=1 STRING: ENSP00000275493
    UBCENSP000003448184STRING: ENSP00000344818
    PXNENSP000002283074STRING: ENSP00000228307
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0008104protein localization IDA17190795

    Find genes that share ontologies with TNS4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNS4 (TENS4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TNS4 gene: 
    NM_032865.5  

    Unigene Cluster for TNS4:

    Tensin 4
    Hs.438292  [show with all ESTs]
    Unigene Representative Sequence: AF370421
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394072(uc002huu.4) ENST00000254051(uc010cxb.3) ENST00000582747
    ENST00000497303
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TNS4 (see all 9):
    hsa-miR-588 hsa-miR-526b hsa-miR-548s hsa-miR-3926 hsa-miR-670 hsa-miR-654-5p hsa-miR-1827 hsa-miR-1207-5p
    SwitchGear 3'UTR luciferase reporter plasmidTNS4 3' UTR sequence
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    OriGene qPCR primer pairs and template standards for TNS4
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    Additional mRNA sequence: 

    AF370421.1 AF417488.1 AK027856.1 BC013373.2 BC018706.1 

    9 DOTS entries:

    DT.95292548  DT.100781354  DT.100009947  DT.100741944  DT.91706356  DT.92053909  DT.91668363  DT.92418153 
    DT.97771696 

    Selected AceView cDNA sequences (see all 122):

    BU169026 BC018706 BF988894 BQ023894 AA368182 BQ026124 BM557866 AW272596 
    BM909790 BQ684844 CA314003 AW272595 BU607467 BU754258 CB850856 BE607411 
    BU679164 BQ941312 BF001857 BF870437 BQ949444 AI831401 BM908322 BQ934801 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNS4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAATAAAA
    TNS4 Expression
    About this image


    TNS4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Lung (Respiratory System)
             Basal Cells Trachea
     
     Placenta (Extraembryonic Tissues)
    TNS4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNS4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.438292

    UniProtKB/Swiss-Prot: TENS4_HUMAN, Q8IZW8
    Tissue specificity: Prostate and placenta. Down regulated in prostate cancer

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TNS4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tns41 , 5 tensin 41, 5 81.36(n)1
    77.23(a)1
      11 (62.92 cM)5
    2171691  NM_172564.31  NP_766152.21 
     990656785 
    chicken
    (Gallus gallus)
    Aves TNS46
    tensin 4
    48(a)
    1 ↔ 1
    27(4448703-4462843)
    lizard
    (Anolis carolinensis)
    Reptilia TNS46
    tensin 4
    43(a)
    1 ↔ 1
    6(70223876-70246257)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.260262 Xenopus laevis transcribed sequence with weak similarity more 74.48(n)    CD100815.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta by6
    blistery
    21(a)
    1 → many
    3R(5353960-5358734)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-1636
    Protein TAG-163, isoform a (tag-163) mRNA, complet...
    15(a)
    1 → many
    I(5583405-5597332) WBGene00006508


    ENSEMBL Gene Tree for TNS4 (if available)
    TreeFam Gene Tree for TNS4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNS4 gene
    DNAJC62  PTEN2  TNS12  TPTE2  TENC12  GAK2  TPTE22  TNS32  
    5 SIMAP similar genes for TNS4 using alignment to 5 protein entries:     TENS4_HUMAN (see all proteins):
    DKFZp434G162    DKFZp434I2435    TNS1    TNS3    TENC1

    Find genes that share paralogs with TNS4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNS4 (see all 606)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365154
    A colorectal cancer sample4--see VAR_0365152 R C mis40--------
    rs1438652941,2
    --38631803(+) GCCCCA/GGGAAA 1 -- int10--------
    rs1463947331,2
    C--38631918(+) GTTTAC/G/TGAAGT 1 -- int10--------
    rs1397843261,2
    --38632017(+) CCCAAA/GTCAGT 1 -- int10--------
    rs1836987561,2
    --38632056(+) CAAGGG/TCACAG 1 -- int10--------
    rs1884095441,2
    --38632094(+) TGCAAA/GGACAA 1 -- ut310--------
    rs1927429431,2
    C--38632163(+) CCAGGC/TTGGGA 1 -- ut310--------
    rs357805671,2
    C,F,H--38632204(+) CACATT/CCTGCA 1 -- ut318Minor allele frequency- C:0.04NS NA WA 912
    rs578032571,2
    C--38632503(+) GTGGGG/TGTGGG 1 -- ut310--------
    rs1846235611,2
    C--38632516(+) AGAGCC/TCAGCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TNS4 (38632080 - 38657854 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TNS4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833445CNV Loss17160897
    nsv908224CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNS4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608385    OMIM disorders: --

    1 disease for TNS4:    
    About MalaCards
    kidney cancer


    Find genes that share disorders with TNS4           About GenesLikeMe

    2 Novoseek inferred disease relationships for TNS4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 9.27 6 17190795 (1), 12154022 (1), 12711115 (1), 19487278 (1) (see all 5)
    breast cancer 6.28 1 17643115 (1)

    Genetic Association Database (GAD): TNS4
    Human Genome Epidemiology (HuGE) Navigator: TNS4 (3 documents)

    Export disorders for TNS4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNS4 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with TNS4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cten, a COOH-terminal tensin-like protein with prostate restricted expression, is down-regulated in prostate cancer. (PubMed id 12154022)1, 2, 3, 9 Lo S.H. and Lo T.B. (Cancer Res. 2002)
    2. Cleavage of cten by caspase-3 during apoptosis. (PubMed id 15806167)1, 2, 9 Lo S.-S.... Lo S.H. (Oncogene 2005)
    3. Cten mRNA expression was correlated with tumor progression in lung cancers. (PubMed id 12711115)1, 3, 9 Sasaki H....Fujii Y. (Lung Cancer 2003)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. CTEN/tensin 4 expression induces sensitivity to paclitaxel in prostate cancer. (PubMed id 19725034)1, 9 Li Y....Namiki M. (Prostate 2010)
    9. Up-regulation of C-terminal tensin-like molecule promotes the tumorigenicity of colon cancer through beta-catenin. (PubMed id 19487278)1, 9 Liao Y.C....Lo S.H. (Cancer Res. 2009)
    10. The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1. (PubMed id 17190795)1, 9 Liao Y.C....Lo S.H. (J. Cell Biol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84951 HGNC: 24352 AceView: CTEN Ensembl:ENSG00000131746 euGenes: HUgn84951
    ECgene: TNS4 H-InvDB: TNS4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TNS4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNS4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNS4 gene:
    Search GeneIP for patents involving TNS4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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