Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNS4 Gene

protein-coding   GIFtS: 51
GCID: GC17M038632

tensin 4

 Explore 11 diseases affiliated with
TNS4 via our new
 Human Malady Compendium 
Biological research products
for TNS4
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Tensin 41 2
CTEN1 2 3 5
C-Terminal Tensin-Like Protein2 3
C Terminal Tensin Like2
Tensin-41

External Ids:    HGNC: 243521   Entrez Gene: 849512   Ensembl: ENSG000001317467   OMIM: 6083855   UniProtKB: Q8IZW83   

Export aliases for TNS4 gene to outside databases

Previous GC identifers: GC17M035886 GC17M034425


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TENS4_HUMAN, Q8IZW8
Function: May be involved in cell migration, cartilage development and in linking signal transduction pathways to the
cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3

Gene Wiki entry for TNS4


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNS4 gene promoter:
         Bach1   GR   GR-beta   Meis-1b   Roaz   AREB6   IRF-7A   GR-alpha   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNS4 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNS4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNS4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

TNS4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNS4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M038632:  view genomic region     (about GC identifiers)

Start:
38,632,080 bp from pter      End:
38,657,854 bp from pter
Size:
25,775 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TENS4_HUMAN, Q8IZW8 (See protein sequence)
Recommended Name: Tensin-4 precursor  
Size: 715 amino acids; 76764 Da
Subunit: Binds to actin filaments and interacts with phosphotyrosine-containing proteins (By similarity)
Subcellular location: Cell junction, focal adhesion. Cytoplasm, cytoskeleton
Sequence caution: Sequence=AAQ15257.1; Type=Frameshift; Positions=85, 296, 472, 602;
Secondary accessions: A6NMJ7 Q71RB7 Q8WV64 Q96JV4

Explore the universe of human proteins at neXtProt for TNS4: NX_Q8IZW8

Post-translational modifications:

  • Proteolytically cleaved by caspase-3 during apoptosis1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IZW8

  • TNS4 Protein expression data from MOPED and PaxDb:    About this image 
    TNS4 Protein Expression
    REFSEQ proteins: NP_116254.4  
    ENSEMBL proteins: 
     ENSP00000254051   ENSP00000463456  

    Human Recombinant Protein Products for TNS4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: TNS4
    OriGene Custom Protein Services for TNS4 
    GenScript Custom Purified and Recombinant Proteins Services for TNS4
    Novus Biologicals TNS4 Protein
    Novus Biologicals TNS4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TNS4

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0005925focal adhesion IDA17190795

    TNS4 for ontologies           About GeneDecksing



    TNS4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for TNS4 (Tensin 4/CTEN)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TNS4 
    GenScript Custom Superior Antibodies Services for TNS4
    Novus Biologicals TNS4 Antibodies
    Abcam antibodies for TNS4 
    Uscn Antibodies for TNS4
    Search ThermoFisher Antibodies for TNS4

    Assay Products for TNS4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TNS4
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TNS4


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TNS4 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR013625 PTB
     IPR000980 SH2
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q8IZW8

    ProtoNet protein and cluster: Q8IZW8

    2 Blocks protein families:
    IPB000980 SH2 domain signature
    IPB013625 Tensin phosphotyrosine-binding domain


    UniProtKB/Swiss-Prot: TENS4_HUMAN, Q8IZW8
    Similarity: Contains 1 phosphatase tensin-type domain
    Similarity: Contains 1 SH2 domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TENS4_HUMAN, Q8IZW8
    Function: May be involved in cell migration, cartilage development and in linking signal transduction pathways to the
    cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI17190795
         
    TNS4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TNS4 

    miRNA
    Products:
        
    miRTarBase miRNAs that target TNS4:
    hsa-mir-1 (MIRT003769)

    OriGene 3'-UTR Clone: TNS4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNS4
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate TNS4 (see all 9):
    hsa-miR-588 hsa-miR-526b hsa-miR-548s hsa-miR-3926 hsa-miR-670 hsa-miR-654-5p hsa-miR-1827 hsa-miR-1207-5p
    SwitchGear 3'UTR luciferase reporter plasmidTNS4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNS4 (see all 7)
    OriGene shRNA RFP: TNS4
    OriGene siRNA: TNS4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNS4
    Sirion Biotech Custom design and validation of potent shRNA sequences against TNS4 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TNS4
    Sirion Biotech Customized adenovirus for overexpression of TNS4 
    Sirion Biotech Customized adenovirus for potent knockdown of TNS4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNS4 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNS4 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TNS4 (NM_032865)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNS4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNS4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TNS4
    Search LifeMap BioReagents cell lines for TNS4
    Sirion Biotech Customized stable knockdown cell line services for TNS4 
    Sirion Biotech Customized inducible knockdown cell line services for TNS4
    Sirion Biotech Customized stable overexpressing cell line services for TNS4
    Sirion Biotech Customized inducible overexpressing cell line services for TNS4

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNS4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TNS4

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for TNS4 (Q8IZW82, 3 ENSP000002540514) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319472, 3MINT-3974963 I2D: score=2 
    ERBB3P218602, 3, ENSP000002671014MINT-74507 I2D: score=1 STRING: ENSP00000267101
    EGFRP005332, 3, ENSP000002754934MINT-74506 I2D: score=1 STRING: ENSP00000275493
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0008104protein localization IDA17190795

    TNS4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNS4
    Search CenterWatch for drugs/clinical trials and news about TNS4 / TENS4 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNS4 gene: 
    NM_032865.5  

    Unigene Cluster for TNS4:

    Tensin 4
    Hs.438292  [show with all ESTs]
    Unigene Representative Sequence: AF370421
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394072(uc002huu.4) ENST00000254051(uc010cxb.3) ENST00000582747
    ENST00000497303

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: TNS4
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNS4
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate TNS4 (see all 9):
    hsa-miR-588 hsa-miR-526b hsa-miR-548s hsa-miR-3926 hsa-miR-670 hsa-miR-654-5p hsa-miR-1827 hsa-miR-1207-5p
    SwitchGear 3'UTR luciferase reporter plasmidTNS4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNS4 (see all 7)
    OriGene shRNA RFP: TNS4
    OriGene siRNA: TNS4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNS4
    Sirion Biotech Custom design and validation of potent shRNA sequences against TNS4 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNS4 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNS4 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TNS4 (NM_032865)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNS4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNS4 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNS4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TNS4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNS4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNS4

    Additional cDNA sequence: 

    AF370421.1 AF417488.1 AK027856.1 BC013373.2 BC018706.1 

    9 DOTS entries:

    DT.95292548  DT.100781354  DT.100009947  DT.100741944  DT.91706356  DT.92053909  DT.91668363  DT.92418153 
    DT.97771696 

    24/122 AceView cDNA sequences (see all 122):

    BM909790 BE607411 AI831401 BM908322 AW272596 BM557866 BQ684844 BF001857 
    BU607467 BF988894 AA368182 BU754258 BQ949444 BQ934801 BC018706 BQ026124 
    BU169026 CA314003 AW272595 BU679164 BQ023894 BF870437 CB850856 BQ941312 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNS4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAAATAAAA
    TNS4 Expression
    About this image
    See TNS4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNS4

    SOURCE GeneReport for Unigene cluster: Hs.438292

    UniProtKB/Swiss-Prot: TENS4_HUMAN, Q8IZW8
    Tissue specificity: Prostate and placenta. Down regulated in prostate cancer

        SABiosciences Custom PCR Arrays for TNS4
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNS4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TNS4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNS4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNS4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNS4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TNS4 gene from 7/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia TNS46
    TNS36
    --
    33(a)
    31(a)
    1 ↔ 1
    possible ortholog
    6(70224833-70246169)
    6(53927804-53939399)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.260262 Xenopus laevis transcribed sequence with weak similarity more 74.48(n)    CD100815.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01092286.16
    --
    32(a)
    1 ↔ 1
    2(23916-32332)
    fruit fly
    (Drosophila melanogaster)
    Insecta by6
    blistery
    21(a)
    1 ↔ 1
    3R(5353960-5358734)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-1636
    Temporarily Assigned Gene name family member (tag-...
    14(a)
    1 ↔ 1
    I(5583408-5597335)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PEN36
    PEN26
    phosphatidylinositol-3,4,5-trisphosphate 3-phospha...
    phosphatidylinositol-3,4,5-trisphosphate 3-phospha...
    5(a)
    5(a)
    possible ortholog
    possible ortholog
    3(18580609-18584535)
    3(6731376-6735623)
    rice
    (Oryza sativa)
    Liliopsida --
    PTEN, putative, expressed
    5(a)
    possible ortholog
    12(12318999-12327551)


    ENSEMBL Gene Tree for TNS4 (if available)
    TreeFam Gene Tree for TNS4 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNS4 gene
    TNS12  DNAJC62  PTEN2  TPTE2  TNS32  TENC12  GAK2  TPTE22  
    5 SIMAP similar genes for TNS4 using alignment to 5 protein entries:     TENS4_HUMAN (see all proteins):
    DKFZp434G162    DKFZp434I2435    TNS1    TNS3    TENC1

    TNS4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/474 NCBI SNPs in TNS4 are shown (see all 474    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1438652941,2
    --38631803(+) GCCCCA/GGGAAA 1 -- int10--------
    rs1463947331,2
    --38631918(+) GTTTAC/GGAAGT 1 -- int10--------
    rs1397843261,2
    --38632017(+) CCCAAA/GTCAGT 1 -- int10--------
    rs1836987561,2
    --38632056(+) CAAGGG/TCACAG 1 -- int10--------
    rs1884095441,2
    --38632094(+) TGCAAA/GGACAA 1 -- ut310--------
    rs1927429431,2
    --38632163(+) CCAGGC/TTGGGA 1 -- ut310--------
    rs357805671,2
    C,F,H--38632204(+) CACATT/CCTGCA 1 -- ut318Minor allele frequency- C:0.04NS NA WA 912
    rs1846235611,2
    --38632516(+) AGAGCC/TCAGCT 1 -- ut310--------
    rs585638081,2
    C,F--38632586(+) TGGCTG/TTGAGG 1 -- ut314Minor allele frequency- T:0.17CSA WA NA 242
    rs614813741,2
    C--38632622(+) TGTGT-/GTGTGT
            
    TGGAG
    1 -- ut311Minor allele frequency- GTGTGT:0.00NA 2

    HapMap Linkage Disequilibrium report for TNS4 (38632080 - 38657854 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TNS4: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNS4
    DNA2.0 Custom Variant and Variant Library Synthesis for TNS4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TNS4 for disorders           About GeneDecksing

    OMIM gene information: 608385    OMIM disorders: --

    11 diseases for TNS4:    About MalaCards
    thymoma    kidney cancer    liver cancer    colon cancer
    gastric cancer    breast carcinoma    colorectal cancer    lung cancer
    prostate cancer    prostatitis    carcinoma

    2 Novoseek disease relationships for TNS4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 9.27 6 17190795 (1), 12154022 (1), 12711115 (1), 19487278 (1) (see all 5)
    breast cancer 6.28 1 17643115 (1)

    Human Genome Epidemiology (HuGE) Navigator: TNS4 (3 documents)

    Export disorders for TNS4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNS4 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with TNS4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cten, a COOH-terminal tensin-like protein with prostate restricted expression, is down-regulated in prostate cancer. (PubMed id 12154022)1, 2, 3, 9 Lo S.H. and Lo T.B. (2002)
    2. Cleavage of cten by caspase-3 during apoptosis. (PubMed id 15806167)1, 2, 9 Lo S.-S.... Lo S.H. (2005)
    3. Cten mRNA expression was correlated with tumor progression in lung cancers. (PubMed id 12711115)1, 3, 9 Sasaki H....Fujii Y. (2003)
    4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. CTEN/tensin 4 expression induces sensitivity to pacli taxel in prostate cancer. (PubMed id 19725034)1, 9 Li Y....Namiki M. (2010)
    8. Up-regulation of C-terminal tensin-like molecule prom otes the tumorigenicity of colon cancer through beta-catenin. (PubMed id 19487278)1, 9 Liao Y.C....Lo S.H. (2009)
    9. The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1. (PubMed id 17190795)1, 9 Liao Y.C....Lo S.H. (2007)
    10. A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration. (PubMed id 17643115)1, 9 Katz M.... Yarden Y. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84951 HGNC: 24352 AceView: CTEN Ensembl:ENSG00000131746 euGenes: HUgn84951
    ECgene: TNS4 H-InvDB: TNS4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNS4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNS4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNS4 gene:
    Search GeneIP for patents involving TNS4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for TNS4 (Tensin 4/CTEN)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for TNS4  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNS4   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNS4  
     OriGene Protein Over-expression Lysate for TNS4   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TNS4   OriGene 3'-UTR Clone for TNS4  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNS4   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNS4  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TNS4   OriGene Custom Protein Services for TNS4  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TNS4
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNS4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNS4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNS4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNS4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNS4
     GenScript Custom Purified and Recombinant Proteins Services for TNS4 GenScript cDNA clones with any tag delivered in your preferred vector for TNS4
     GenScript Custom Assay Services for TNS4 GenScript Custom Superior Antibodies Services for TNS4
     GenScript Custom overexpressing Cell Line Services for TNS4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TNS4 promoter
     Search Chromatin IP Primers for TNS4
     RT2 qPCR Primer Assay in human, mouse, rat TNS4
     Search GNC Networks for TNS4
     SABiosciences Custom PCR Arrays for TNS4
     Search Tocris compounds for TNS4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TNS4 antibodies
     TNS4 proteins
     TNS4 lysates
     Antibodies for TNS4
     See all of Abcam's Antibodies, Kits and Proteins for TNS4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     TNS4 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for TNS4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNS4
     SwitchGear 3'UTR luciferase reporter plasmids for TNS4
     SwitchGear Promoter luciferase reporter plasmids for TNS4
     Search ThermoFisher Antibodies for TNS4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNS4
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TNS4
    Sirion Biotech Customized:
     stable knockdown cell line services for TNS4
     inducible knockdown cell line services for TNS4
     design and validation of potent shRNA sequences against TNS4
     adenovirus for potent knockdown of TNS4
     adenovirus for overexpression of TNS4
     stable overexpressing cell line services for TNS4
     inducible overexpressing cell line services for TNS4
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TNS4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4