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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNS3 Gene

protein-coding   GIFtS: 52
GCID: GC07M047281

Tensin 3

(Previous name: tensin-like SH2 domain-containing 1)
(Previous symbol: TENS1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tensin 31 2     Tensin-Like SH2 Domain-Containing Protein 12 3
TENS11 2 3     tensin-32
Tumor Endothelial Marker 61 2 3     Tensin-Like SH2 Domain Containing 12
TEM62 3 5     Thyroid Specific PTB Domain Protein2
Tensin-Like SH2 Domain-Containing 11 2     TPP3

External Ids:    HGNC: 216161   Entrez Gene: 647592   Ensembl: ENSG000001362057   OMIM: 6068255   UniProtKB: Q68CZ23   

Export aliases for TNS3 gene to outside databases

Previous GC identifer: GC07M047088


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TNS3 Gene: 
TNS3 (tensin 3) is a protein-coding gene. Diseases associated with TNS3 include silver-russell syndrome, and kidney cancer. GO annotations related to this gene include protein binding. An important paralog of this gene is PTEN.

UniProtKB/Swiss-Prot: TENS3_HUMAN, Q68CZ2
Function: May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex.
EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in
mammary cell migration. May be involved in cell migration and bone development (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNS3 gene promoter:
         Max1   AREB6   SRY   deltaCREB   FOXD3   Tal-1beta   ITF-2   c-Myc   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): TNS3 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNS3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p12.3   Ensembl cytogenetic band:  7p12.3   HGNC cytogenetic band: 7p12.3

TNS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNS3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M047281:  view genomic region     (about GC identifiers)

Start:
47,314,752 bp from pter      End:
47,622,156 bp from pter
Size:
307,405 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 47,354,555-47,661,993     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TENS3_HUMAN, Q68CZ2 (See protein sequence)
Recommended Name: Tensin-3  
Size: 1445 amino acids; 155266 Da
Subunit: EGF promotes the interaction with EGFR. Interacts with PTK2/FAK1 and BCAR1. Tyrosine phosphorylation is
critical for these interactions
Subcellular location: Cell junction, focal adhesion
Secondary accessions: B2RNV1 Q6IPQ2 Q8IZW7 Q8NAD0 Q96PE0 Q96S48
Alternative splicing: 4 isoforms:  Q68CZ2-1   Q68CZ2-2   Q68CZ2-3   Q68CZ2-4   

Explore the universe of human proteins at neXtProt for TNS3: NX_Q68CZ2

Explore proteomics data for TNS3 at MOPED 

Post-translational modifications:

  • UniProtKB: EGF/epidermal growth factor induces tyrosine phosphorylation in a time- and dose-dependent manner
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q68CZ2

  • TNS3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TNS3 Protein Expression
    REFSEQ proteins: NP_073585.8  
    ENSEMBL proteins: 
     ENSP00000387990   ENSP00000312143   ENSP00000414358   ENSP00000396914   ENSP00000389285  
     ENSP00000409415   ENSP00000388142   ENSP00000407464   ENSP00000381854   ENSP00000347968  
     ENSP00000388318  

    Human Recombinant Protein Products for TNS3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TNS3
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TNS3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005925focal adhesion IEA--

    TNS3 for ontologies           About GeneDecksing



    TNS3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TNS3
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    Cloud-Clone Corp. Antibodies for TNS3 
    Search ThermoFisher Antibodies for TNS3
    LSBio Antibodies in human, mouse, rat for TNS3 

    Assay Products for TNS3: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for TNS3 
    Cloud-Clone Corp. CLIAs for TNS3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SH2D: SH2 domain containing

    5/7 InterPro protein domains (see all 7):
     IPR014019 Phosphatase_tensin-typ
     IPR013625 PTB
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR006020 PTyr_interaction_dom
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q68CZ2

    ProtoNet protein and cluster: Q68CZ2

    3 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB006020 Phosphotyrosine interaction domain
    IPB013625 Tensin phosphotyrosine-binding domain


    UniProtKB/Swiss-Prot: TENS3_HUMAN, Q68CZ2
    Similarity: Contains 1 C2 tensin-type domain
    Similarity: Contains 1 phosphatase tensin-type domain
    Similarity: Contains 1 SH2 domain


    TNS3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TENS3_HUMAN, Q68CZ2
    Function: May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex.
    EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in
    mammary cell migration. May be involved in cell migration and bone development (By similarity)
    Induction: Down-regulated by EGF

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16273093
    GO:0016791phosphatase activity ----
    GO:0046872metal ion binding ----
         
    TNS3 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tns3):
     cellular  digestive/alimentary  growth/size  hematopoietic system  immune system 
     mortality/aging  respiratory system  skeleton 

    TNS3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TNS3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TNS3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNS3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNS3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNS3
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate TNS3 (see all 40):
    hsa-miR-579 hsa-miR-3664-5p hsa-miR-300 hsa-miR-200a hsa-miR-141 hsa-miR-1184 hsa-miR-1243 hsa-miR-28-5p
    SwitchGear 3'UTR luciferase reporter plasmidTNS3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TNS3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNS3

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of TNS3

    Clone
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    OriGene ORF clones in mouse, rat for TNS3
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    GenScript: all cDNA clones in your preferred vector: TNS3 (NM_022748)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNS3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNS3
    Sirion Biotech Customized lentivirus for stable overexpression of TNS3 
                         Customized lentivirus expression plasmids for stable overexpression of TNS3 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNS3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNS3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for TNS3 (Q68CZ21, 2, 3 ENSP000003121434) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046262, 3, ENSP000002695714MINT-74785 MINT-74786 I2D: score=2 STRING: ENSP00000269571
    ERBB3P218602, 3, ENSP000002671014MINT-74787 MINT-74788 I2D: score=2 STRING: ENSP00000267101
    BCAR1P569451, 3, ENSP000001623304EBI-1220488,EBI-702093 I2D: score=1 STRING: ENSP00000162330
    SRCP129311, 3, ENSP000003509414EBI-1220488,EBI-621482 I2D: score=1 STRING: ENSP00000350941
    CDH1P128301, 3, ENSP000002617694EBI-1220488,EBI-727477 I2D: score=1 STRING: ENSP00000261769
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0016311dephosphorylation ----
    GO:0016477cell migration IEA--
    GO:0035556intracellular signal transduction ----
    GO:0048286lung alveolus development IEA--

    TNS3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNS3 (TENS3)

    Search CenterWatch for drugs/clinical trials and news about TNS3 / TENS3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNS3 gene: 
    NM_022748.11  

    Unigene Cluster for TNS3:

    Tensin 3
    Hs.520814  [show with all ESTs]
    Unigene Representative Sequence: NM_022748
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000428457 ENST00000311160(uc022acn.1 uc003tnw.3) ENST00000457718
    ENST00000450444 ENST00000469470 ENST00000485555 ENST00000442536 ENST00000415929
    ENST00000413551 ENST00000434451 ENST00000474346 ENST00000398879(uc010kyo.1)
    ENST00000355730 ENST00000458317
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNS3
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate TNS3 (see all 40):
    hsa-miR-579 hsa-miR-3664-5p hsa-miR-300 hsa-miR-200a hsa-miR-141 hsa-miR-1184 hsa-miR-1243 hsa-miR-28-5p
    SwitchGear 3'UTR luciferase reporter plasmidTNS3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TNS3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNS3
    Clone
    Products:
         
    OriGene clones in human, mouse for TNS3 (see all 5)
    OriGene ORF clones in mouse, rat for TNS3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TNS3 (NM_022748)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNS3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNS3
    Sirion Biotech Customized lentivirus for stable overexpression of TNS3 
                         Customized lentivirus expression plasmids for stable overexpression of TNS3 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TNS3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TNS3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNS3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNS3

    Additional mRNA sequence: 

    AB062750.1 AB208995.1 AF378756.1 AF417489.1 AK001539.1 AK002151.1 AK023794.1 AK092864.1 
    AK310472.1 AL137468.1 AL833845.1 BC071791.1 BC137133.1 BC137134.1 BX648770.1 BX649002.1 
    CR749644.1 

    15 DOTS entries:

    DT.418860  DT.102843041  DT.101958181  DT.95097480  DT.100677166  DT.91819529  DT.121079065  DT.65288625 
    DT.40130292  DT.95092142  DT.121079009  DT.121079033  DT.95092143  DT.95158153  DT.95106163 

    24/313 AceView cDNA sequences (see all 313):

    AF417489 AI160176 AA046614 AA369620 AX747776 CF456305 BC071791 BG252262 
    BQ008901 BQ881569 AI147912 AA745687 AW440418 AI962940 BM981355 BM975038 
    CD678690 BF338534 BF115643 BU726443 BU617205 AI191442 BX345159 CA748544 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNS3 expression in normal human tissues (normalized intensities)      TNS3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAAAGTCA
    TNS3 Expression
    About this image


    TNS3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Endochondral Facial Bones
             skeleton/cranium/viscerocranium   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             sensory organ/nose/nasal septum   
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium/viscerocranium   
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Ovary (Reproductive System)
             Pre-Granulosa Cells Primordial Follicle

    See TNS3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNS3

    SOURCE GeneReport for Unigene cluster: Hs.520814

    UniProtKB/Swiss-Prot: TENS3_HUMAN, Q68CZ2
    Tissue specificity: Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at
    protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle,
    spleen, liver, and lung. Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid
    tumor tissues and in anaplastic carcinomas

        SABiosciences Custom PCR Arrays for TNS3
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNS3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNS3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TNS3 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tns31 , 5 tensin 31, 5 82.79(n)1
    83.72(a)1
      11 (4.99 cM)5
    3199391  NM_001083587.11  NP_001077056.11 
     84316525 
    chicken
    (Gallus gallus)
    Aves LOC1008571781 tensin-3-like 66.72(n)
    64.64(a)
      100857178  XM_003640747.1  XP_003640795.1 
    lizard
    (Anolis carolinensis)
    Reptilia TNS36
    Uncharacterized protein
    82(a)
    1 ↔ 1
    6(53925584-53958536)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.164102 Transcribed sequence with moderate similarity to protein more 75.97(n)    BX695335.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.234472 Transcribed sequence with moderate similarity to protein more 79.45(n)    57048926 
    fruit fly
    (Drosophila melanogaster)
    Insecta by6
    blistery
    27(a)
    1 → many
    3R(5353960-5358734)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-1636
    Protein TAG-163, isoform c
    22(a)
    1 → many
    I(5583405-5597332)


    ENSEMBL Gene Tree for TNS3 (if available)
    TreeFam Gene Tree for TNS3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNS3 gene
    PTEN2  DNAJC62  TNS12  TPTE2  TNS42  TENC12  GAK2  TPTE22  
    8 SIMAP similar genes for TNS3 using alignment to 8 protein entries:     TENS3_HUMAN (see all proteins):
    DKFZp434I2435    DKFZp434G162    TNS1    TNS4    PTEN    GAK
    PTEN2    TENC1

    TNS3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6634 SNPs in TNS3 are shown (see all 6634)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs745634491,2
    C,F--47314376(+) CCAGTG/ATGTGT 1 -- int11Minor allele frequency- A:0.06WA 118
    rs126711711,2
    C,H--47314464(+) CTTTGA/TATATA 1 -- int14Minor allele frequency- T:0.00NS EA 414
    rs1483848661,2
    C--47314591(+) ACACAC/TGCAGA 1 -- int10--------
    rs1913976821,2
    --47314685(+) GCACAC/TGCATA 1 -- int10--------
    rs731069921,2
    --47314686(+) CACACA/GCATAC 1 -- int10--------
    rs1472319561,2
    C--47314704(+) TGCAA-/ACACACA 1 -- int10--------
    rs1504144771,2
    --47314746(+) CTCACA/GGAGGC 1 -- int10--------
    rs1824341191,2
    --47314844(+) TTCATC/TTACAT 1 -- ut310--------
    rs1871587591,2
    --47315028(+) CCTGGC/TTATAA 1 -- ut310--------
    rs3752365571,2
    C--47315098(+) GTCCA-/GCGG  
      GAGCCC
    TGGAG
    1 -- ut310--------

    HapMap Linkage Disequilibrium report for TNS3 (47314752 - 47564752 bp, first 250kb of TNS3)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for TNS3 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734355CNV Deletion23290073
    esv994753CNV Deletion20482838
    esv2734353CNV Deletion23290073
    esv2183820CNV Deletion18987734
    esv2734357CNV Deletion23290073
    esv2734356CNV Deletion23290073
    esv2734354CNV Deletion23290073
    esv2654714CNV Insertion19546169
    esv271469CNV Insertion20981092
    esv271919CNV Insertion20981092


    Human Gene Mutation Database (HGMD): TNS3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TNS3
    DNA2.0 Custom Variant and Variant Library Synthesis for TNS3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606825    OMIM disorders: --

    5 diseases for TNS3:    About MalaCards
    silver-russell syndrome    kidney cancer    endotheliitis    thyroiditis
    adenoma


    TNS3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TNS3
    Human Genome Epidemiology (HuGE) Navigator: TNS3 (1 document)

    Export disorders for TNS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNS3 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with TNS3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cell surface tumor endothelial markers are conserved in mice and humans. (PubMed id 11559528)1, 2, 3 Carson-Walter E.B....St Croix B. (2001)
    2. A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration. (PubMed id 17643115)1, 2, 9 Katz M.... Yarden Y. (2007)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Tensin3 is a novel thyroid-specific gene. (PubMed id 16461921)1, 2 Maeda I.... Miyauchi A. (2006)
    5. Epidermal growth factor modulates tyrosine phosphorylation of a novel tensin family member, tensin3. (PubMed id 15140944)1, 2 Cui Y.... Lo S.H. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Cytogenetic and molecular characterization of a de-novo t(2p;7p) translocation involving TNS3 and EXOC6B genes in a boy with a complex syndromic phenotype. (PubMed id 18424204)1, 9 Borsani G....Barlati S. (2008)
    8. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64759 HGNC: 21616 AceView: TENS1 Ensembl:ENSG00000136205 euGenes: HUgn64759
    ECgene: TNS3 H-InvDB: TNS3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNS3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNS3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNS3 gene:
    Search GeneIP for patents involving TNS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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