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Aliases for TNS3 Gene

Aliases for TNS3 Gene

  • Tensin 3 2 3 5
  • Tumor Endothelial Marker 6 2 3 4
  • Tensin-Like SH2 Domain-Containing Protein 1 3 4
  • Tensin-Like SH2 Domain-Containing 1 2 3
  • TENS1 3 4
  • TEM6 3 4
  • Tensin-Like SH2 Domain Containing 1 3
  • Thyroid Specific PTB Domain Protein 3
  • TPP 4

External Ids for TNS3 Gene

Previous HGNC Symbols for TNS3 Gene

  • TENS1

Previous GeneCards Identifiers for TNS3 Gene

  • GC07M047088

Summaries for TNS3 Gene

GeneCards Summary for TNS3 Gene

TNS3 (Tensin 3) is a Protein Coding gene. Diseases associated with TNS3 include anisakiasis and primary syphilis. GO annotations related to this gene include phosphatase activity. An important paralog of this gene is TNS1.

UniProtKB/Swiss-Prot for TNS3 Gene

  • May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNS3 Gene

Genomics for TNS3 Gene

Regulatory Elements for TNS3 Gene

Promoters for TNS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TNS3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TNS3 Gene

Chromosome:
7
Start:
47,275,144 bp from pter
End:
47,582,558 bp from pter
Size:
307,415 bases
Orientation:
Minus strand

Genomic View for TNS3 Gene

Genes around TNS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNS3 Gene

Proteins for TNS3 Gene

  • Protein details for TNS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68CZ2-TENS3_HUMAN
    Recommended name:
    Tensin-3
    Protein Accession:
    Q68CZ2
    Secondary Accessions:
    • B2RNV1
    • Q6IPQ2
    • Q8IZW7
    • Q8NAD0
    • Q96PE0
    • Q96S48

    Protein attributes for TNS3 Gene

    Size:
    1445 amino acids
    Molecular mass:
    155266 Da
    Quaternary structure:
    • EGF promotes the interaction with EGFR. Interacts with PTK2/FAK1 and BCAR1. Tyrosine phosphorylation is critical for these interactions.

    Alternative splice isoforms for TNS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNS3 Gene

Proteomics data for TNS3 Gene at MOPED

Post-translational modifications for TNS3 Gene

  • EGF/epidermal growth factor induces tyrosine phosphorylation in a time- and dose-dependent manner.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for TNS3 Gene

Domains & Families for TNS3 Gene

Suggested Antigen Peptide Sequences for TNS3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q68CZ2

UniProtKB/Swiss-Prot:

TENS3_HUMAN :
  • Contains 1 C2 tensin-type domain.
Domain:
  • Contains 1 C2 tensin-type domain.
  • Contains 1 phosphatase tensin-type domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with TNS3: view

Function for TNS3 Gene

Molecular function for TNS3 Gene

UniProtKB/Swiss-Prot Function:
May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development (By similarity).
UniProtKB/Swiss-Prot Induction:
Down-regulated by EGF.
genes like me logo Genes that share phenotypes with TNS3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TNS3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNS3 Gene

Localization for TNS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNS3 Gene

Cell junction, focal adhesion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNS3 Gene COMPARTMENTS Subcellular localization image for TNS3 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TNS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with TNS3: view

Pathways & Interactions for TNS3 Gene

SuperPathways for TNS3 Gene

No Data Available

SIGNOR curated interactions for TNS3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TNS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048286 lung alveolus development IEA --
genes like me logo Genes that share ontologies with TNS3: view

No data available for Pathways by source for TNS3 Gene

Drugs & Compounds for TNS3 Gene

No Compound Related Data Available

Transcripts for TNS3 Gene

Unigene Clusters for TNS3 Gene

Tensin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNS3 Gene

No ASD Table

Relevant External Links for TNS3 Gene

GeneLoc Exon Structure for
TNS3
ECgene alternative splicing isoforms for
TNS3

Expression for TNS3 Gene

mRNA expression in normal human tissues for TNS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TNS3 Gene

This gene is overexpressed in Placenta (14.3), Ovary (7.4), and Spleen (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNS3 Gene



SOURCE GeneReport for Unigene cluster for TNS3 Gene Hs.520814

mRNA Expression by UniProt/SwissProt for TNS3 Gene

Q68CZ2-TENS3_HUMAN
Tissue specificity: Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid tumor tissues and in anaplastic carcinomas.
genes like me logo Genes that share expression patterns with TNS3: view

Protein tissue co-expression partners for TNS3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TNS3 Gene

Orthologs for TNS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNS3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TNS3 35
  • 82.96 (n)
  • 82.52 (a)
TNS3 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNS3 35
  • 80.27 (n)
  • 79.94 (a)
-- 36
  • 79 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tns3 35
  • 82.7 (n)
  • 83.65 (a)
Tns3 16
Tns3 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TNS3 35
  • 99.47 (n)
  • 99.65 (a)
TNS3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tns3 35
  • 83.03 (n)
  • 83.61 (a)
oppossum
(Monodelphis domestica)
Mammalia TNS3 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNS3 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNS3 35
  • 67.78 (n)
  • 67.85 (a)
TNS3 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNS3 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16410 35
tns3 35
  • 58.97 (n)
  • 58.63 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.23447 35
TNS3 (1 of 3) 36
  • 44 (a)
OneToMany
TNS3 (2 of 3) 36
  • 72 (a)
OneToMany
TNS3 (3 of 3) 36
  • 44 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta by 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-163 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for TNS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TNS3 Gene

ENSEMBL:
Gene Tree for TNS3 (if available)
TreeFam:
Gene Tree for TNS3 (if available)

Paralogs for TNS3 Gene

Paralogs for TNS3 Gene

genes like me logo Genes that share paralogs with TNS3: view

Variants for TNS3 Gene

Sequence variations from dbSNP and Humsavar for TNS3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2293362 - 47,368,846(+) CTATA(A/C/G)TGGTG reference, missense
rs7808646 - 47,368,611(+) TGGGC(C/T)GGCTC reference, missense
rs3807590 - 47,303,307(-) CGCCC(A/G)AGGAG reference, missense
rs3323 -- 47,359,800(+) TAGAA(A/G)GTATC intron-variant
rs9876 -- 47,275,693(-) TTCCA(C/T)GATTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TNS3 Gene

Variant ID Type Subtype PubMed ID
esv2654714 CNV Insertion 19546169
nsv366041 CNV Loss 16902084
esv2734353 CNV Deletion 23290073
esv2734354 CNV Deletion 23290073
esv2734355 CNV Deletion 23290073
nsv365584 CNV Loss 16902084
nsv507387 CNV Insertion 20534489
esv271919 CNV Insertion 20981092
esv273058 CNV Insertion 20981092
esv2734356 CNV Deletion 23290073
esv2183820 CNV Deletion 18987734
esv2734357 CNV Deletion 23290073
esv271469 CNV Insertion 20981092
esv994753 CNV Deletion 20482838
nsv509196 CNV Insertion 20534489

Variation tolerance for TNS3 Gene

Residual Variation Intolerance Score: 15.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.35; 70.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNS3 Gene

HapMap Linkage Disequilibrium report
TNS3
Human Gene Mutation Database (HGMD)
TNS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNS3 Gene

Disorders for TNS3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TNS3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
anisakiasis
  • infection by anisakis larva
primary syphilis
  • early symptomatic syphilis
- elite association - COSMIC cancer census association via MalaCards
Search TNS3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TNS3

Genetic Association Database (GAD)
TNS3
Human Genome Epidemiology (HuGE) Navigator
TNS3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNS3
genes like me logo Genes that share disorders with TNS3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNS3 Gene

Publications for TNS3 Gene

  1. Cell surface tumor endothelial markers are conserved in mice and humans. (PMID: 11559528) Carson-Walter E.B. … St Croix B. (Cancer Res. 2001) 2 3 4 67
  2. Cytogenetic and molecular characterization of a de-novo t(2p;7p) translocation involving TNS3 and EXOC6B genes in a boy with a complex syndromic phenotype. (PMID: 18424204) Borsani G. … Barlati S. (Eur J Med Genet 2008) 3 23
  3. A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration. (PMID: 17643115) Katz M. … Yarden Y. (Nat. Cell Biol. 2007) 3 23
  4. In silico prediction of physical protein interactions and characterization of interactome orphans. (PMID: 25402006) Kotlyar M. … Jurisica I. (Nat. Methods 2015) 3
  5. SUV420H2 suppresses breast cancer cell invasion through down regulation of the SH2 domain-containing focal adhesion protein tensin-3. (PMID: 25814362) Shinchi Y. … Matsuura N. (Exp. Cell Res. 2015) 3

Products for TNS3 Gene

Sources for TNS3 Gene

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