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Aliases for TNS3 Gene

Aliases for TNS3 Gene

  • Tensin 3 2 3
  • Tumor Endothelial Marker 6 2 3 4
  • TEM6 3 4 6
  • Tensin-Like SH2 Domain-Containing Protein 1 3 4
  • Tensin-Like SH2 Domain-Containing 1 2 3
  • TENS1 3 4
  • Tensin-Like SH2 Domain Containing 1 3
  • Thyroid Specific PTB Domain Protein 3
  • Tensin-3 3
  • TPP 4

External Ids for TNS3 Gene

Previous HGNC Symbols for TNS3 Gene

  • TENS1

Previous GeneCards Identifiers for TNS3 Gene

  • GC07M047088

Summaries for TNS3 Gene

GeneCards Summary for TNS3 Gene

TNS3 (Tensin 3) is a Protein Coding gene. An important paralog of this gene is TNS1.

UniProtKB/Swiss-Prot for TNS3 Gene

  • May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNS3 Gene

Genomics for TNS3 Gene

Regulatory Elements for TNS3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TNS3 Gene

Start:
47,275,154 bp from pter
End:
47,582,558 bp from pter
Size:
307,405 bases
Orientation:
Minus strand

Genomic View for TNS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNS3 Gene

Proteins for TNS3 Gene

  • Protein details for TNS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68CZ2-TENS3_HUMAN
    Recommended name:
    Tensin-3
    Protein Accession:
    Q68CZ2
    Secondary Accessions:
    • B2RNV1
    • Q6IPQ2
    • Q8IZW7
    • Q8NAD0
    • Q96PE0
    • Q96S48

    Protein attributes for TNS3 Gene

    Size:
    1445 amino acids
    Molecular mass:
    155266 Da
    Quaternary structure:
    • EGF promotes the interaction with EGFR. Interacts with PTK2/FAK1 and BCAR1. Tyrosine phosphorylation is critical for these interactions.

    Alternative splice isoforms for TNS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNS3 Gene

Proteomics data for TNS3 Gene at MOPED

Post-translational modifications for TNS3 Gene

  • EGF/epidermal growth factor induces tyrosine phosphorylation in a time- and dose-dependent manner
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TNS3 Gene

Domains for TNS3 Gene

Gene Families for TNS3 Gene

HGNC:
  • SH2D :SH2 domain containing

Suggested Antigen Peptide Sequences for TNS3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q68CZ2

UniProtKB/Swiss-Prot:

TENS3_HUMAN :
  • Q68CZ2
Domain:
  • Contains 1 C2 tensin-type domain.
  • Contains 1 phosphatase tensin-type domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with TNS3: view

Function for TNS3 Gene

Molecular function for TNS3 Gene

UniProtKB/Swiss-Prot Function: May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development (By similarity).
UniProtKB/Swiss-Prot Induction: Down-regulated by EGF.

Gene Ontology (GO) - Molecular Function for TNS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16273093
GO:0016791 phosphatase activity --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with TNS3: view
genes like me logo Genes that share phenotypes with TNS3: view

Animal Model Products

CRISPR Products

miRNA for TNS3 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNS3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TNS3 Gene

Localization for TNS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNS3 Gene

Cell junction, focal adhesion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNS3 Gene COMPARTMENTS Subcellular localization image for TNS3 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TNS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005925 focal adhesion IDA --
genes like me logo Genes that share ontologies with TNS3: view

Pathways for TNS3 Gene

SuperPathways for TNS3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TNS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IEA --
GO:0016311 dephosphorylation --
GO:0016477 cell migration IEA --
GO:0035556 intracellular signal transduction --
GO:0048286 lung alveolus development IEA --
genes like me logo Genes that share ontologies with TNS3: view

No data available for Pathways by source for TNS3 Gene

Transcripts for TNS3 Gene

Unigene Clusters for TNS3 Gene

Tensin 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNS3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TNS3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNS3 Gene

No ASD Table

Relevant External Links for TNS3 Gene

GeneLoc Exon Structure for
TNS3
ECgene alternative splicing isoforms for
TNS3

Expression for TNS3 Gene

mRNA expression in normal human tissues for TNS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNS3 Gene

SOURCE GeneReport for Unigene cluster for TNS3 Gene Hs.520814

mRNA Expression by UniProt/SwissProt for TNS3 Gene

Q68CZ2-TENS3_HUMAN
Tissue specificity: Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid tumor tissues and in anaplastic carcinomas.
genes like me logo Genes that share expressions with TNS3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TNS3 Gene

Orthologs for TNS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNS3 35
  • 99.47 (n)
  • 99.65 (a)
TNS3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TNS3 35
  • 82.96 (n)
  • 82.52 (a)
TNS3 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
TNS3 35
  • 80.27 (n)
  • 79.94 (a)
mouse
(Mus musculus)
Mammalia Tns3 35
  • 82.7 (n)
  • 83.65 (a)
Tns3 16
Tns3 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNS3 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNS3 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tns3 35
  • 83.03 (n)
  • 83.61 (a)
chicken
(Gallus gallus)
Aves TNS3 35
  • 67.78 (n)
  • 67.85 (a)
TNS3 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNS3 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16410 35
tns3 35
  • 58.97 (n)
  • 58.63 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.23447 35
TNS3 (1 of 3) 36
  • 44 (a)
OneToMany
TNS3 (2 of 3) 36
  • 72 (a)
OneToMany
TNS3 (3 of 3) 36
  • 44 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta by 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-163 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for TNS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TNS3 Gene

ENSEMBL:
Gene Tree for TNS3 (if available)
TreeFam:
Gene Tree for TNS3 (if available)

Paralogs for TNS3 Gene

Paralogs for TNS3 Gene

genes like me logo Genes that share paralogs with TNS3: view

Variants for TNS3 Gene

Sequence variations from dbSNP and Humsavar for TNS3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs3323 -- 47,359,800(+) TAGAA(A/G)GTATC intron-variant
rs9876 -- 47,275,693(-) TTCCA(C/T)GATTT utr-variant-3-prime
rs700755 -- 47,406,044(+) TGATG(A/G)GCCCG intron-variant
rs834591 -- 47,434,888(-) AGTTA(A/T)GGTAA intron-variant
rs834592 -- 47,434,730(+) GCTGC(C/T)GGCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNS3 Gene

Variant ID Type Subtype PubMed ID
esv2654714 CNV Insertion 19546169
nsv366041 CNV Loss 16902084
esv2734353 CNV Deletion 23290073
esv2734354 CNV Deletion 23290073
esv2734355 CNV Deletion 23290073
nsv365584 CNV Loss 16902084
nsv507387 CNV Insertion 20534489
esv271919 CNV Insertion 20981092
esv273058 CNV Insertion 20981092
esv2734356 CNV Deletion 23290073
esv2183820 CNV Deletion 18987734
esv2734357 CNV Deletion 23290073
esv271469 CNV Insertion 20981092
esv994753 CNV Deletion 20482838
nsv509196 CNV Insertion 20534489

Relevant External Links for TNS3 Gene

HapMap Linkage Disequilibrium report
TNS3
Human Gene Mutation Database (HGMD)
TNS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNS3 Gene

Disorders for TNS3 Gene

Relevant External Links for TNS3

Genetic Association Database (GAD)
TNS3
Human Genome Epidemiology (HuGE) Navigator
TNS3
genes like me logo Genes that share disorders with TNS3: view

No data available for UniProtKB/Swiss-Prot for TNS3 Gene

Publications for TNS3 Gene

  1. A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration. (PMID: 17643115) Katz M. … Yarden Y. (Nat. Cell Biol. 2007) 3 4 23
  2. Cell surface tumor endothelial markers are conserved in mice and humans. (PMID: 11559528) Carson-Walter E.B. … St Croix B. (Cancer Res. 2001) 2 3 4
  3. Tensin3 is a novel thyroid-specific gene. (PMID: 16461921) Maeda I. … Miyauchi A. (J. Mol. Endocrinol. 2006) 3 4
  4. Cytogenetic and molecular characterization of a de-novo t(2p;7p) translocation involving TNS3 and EXOC6B genes in a boy with a complex syndromic phenotype. (PMID: 18424204) Borsani G. … Barlati S. (Eur J Med Genet 2008) 3 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for TNS3 Gene

Sources for TNS3 Gene

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