Aliases for TNS2 Gene
External Ids for TNS2 Gene
Previous HGNC Symbols for TNS2 Gene
The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNS2 Gene
TNS2 (Tensin 2) is a Protein Coding gene. Among its related pathways are PI3K / Akt Signaling and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include kinase binding and phosphoprotein phosphatase activity. An important paralog of this gene is TNS1.
UniProtKB/Swiss-Prot for TNS2 Gene
Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling.