Aliases for TNS2 Gene
External Ids for TNS2 Gene
Previous HGNC Symbols for TNS2 Gene
The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNS2 Gene
TNS2 (Tensin 2) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and Adhesion. GO annotations related to this gene include kinase binding and phosphoprotein phosphatase activity. An important paralog of this gene is TNS1.
UniProtKB/Swiss-Prot for TNS2 Gene
Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling.