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Aliases for TNS2 Gene

Aliases for TNS2 Gene

  • Tensin 2 2 3 5
  • Tensin Like C1 Domain Containing Phosphatase (Tensin 2) 2 3
  • C1 Domain-Containing Phosphatase And Tensin Homolog 3 4
  • Tensin-Like C1 Domain-Containing Phosphatase 3 4
  • C1-TEN 3 4
  • TENC1 3 4
  • Tensin Like C1 Domain-Containing Phosphatase 2
  • EC 3.1.3.- 4
  • Tensin-2 3
  • KIAA1075 4
  • C1TEN 3

External Ids for TNS2 Gene

Previous HGNC Symbols for TNS2 Gene

  • TENC1

Summaries for TNS2 Gene

Entrez Gene Summary for TNS2 Gene

  • The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNS2 Gene

TNS2 (Tensin 2) is a Protein Coding gene. Among its related pathways are Adhesion and PI3K / Akt Signaling. GO annotations related to this gene include kinase binding and phosphoprotein phosphatase activity. An important paralog of this gene is TNS1.

UniProtKB/Swiss-Prot for TNS2 Gene

  • Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling.

Gene Wiki entry for TNS2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNS2 Gene

Genomics for TNS2 Gene

Regulatory Elements for TNS2 Gene

Enhancers for TNS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G053043 2.1 FANTOM5 Ensembl ENCODE dbSUPER 18.7 +2.6 2644 12.0 MLX AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC PPARGC1A MEF2D LOC283335 EIF4B TNS2 HOXC6 HOXC4 HOXC9 HOXC8 IGFBP6 C12orf10 SPRYD3
GH12G053215 1.8 FANTOM5 ENCODE dbSUPER 8.9 +174.0 173955 10.1 HDGF PKNOX1 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A ZNF2 ZBTB7B MAP3K12 RARG TNS2 SP1 IGFBP6 PFDN5 C12orf10 TARBP2 ZNF740 LOC100240734
GH12G053060 1.6 Ensembl ENCODE dbSUPER 8.8 +20.0 19960 13.5 HDGF PKNOX1 FOXA2 MLX AGO1 ARID4B SIN3A YBX1 DMAP1 ZNF2 PFDN5 AAAS LOC283335 LOC100652999 IGFBP6 SOAT2 ZNF740 ITGB7 RNU6-333P ESPL1
GH12G052991 1.5 Ensembl ENCODE dbSUPER 8.8 -54.3 -54252 2.6 FOXA2 ARID4B DMAP1 ZNF121 FOS REST PPARG ZNF592 MIER3 SMARCA4 EIF4B KRT18 TNS2 SPRYD3 KRT8
GH12G052974 1.6 Ensembl ENCODE dbSUPER 4.5 -70.9 -70851 3.5 HDGF FOXA2 PKNOX1 ARID4B SIN3A YBX1 ZNF2 ZBTB7B YY1 SLC30A9 EIF4B KRT18 KRT82 KRT71 KRT84 SOAT2 IGFBP6 KRT8 TNS2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNS2 on UCSC Golden Path with GeneCards custom track

Promoters for TNS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000268410 331 1401 HDGF PKNOX1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B

Genomic Location for TNS2 Gene

Chromosome:
12
Start:
53,046,969 bp from pter
End:
53,064,379 bp from pter
Size:
17,411 bases
Orientation:
Plus strand

Genomic View for TNS2 Gene

Genes around TNS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNS2 Gene

Proteins for TNS2 Gene

  • Protein details for TNS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q63HR2-TNS2_HUMAN
    Recommended name:
    Tensin-2
    Protein Accession:
    Q63HR2
    Secondary Accessions:
    • A2VDF2
    • A2VDF3
    • A2VDI8
    • A5PKY4
    • Q2NL80
    • Q76MW6
    • Q7Z5T9
    • Q8NFF9
    • Q8NFG0
    • Q96P25
    • Q9NT29
    • Q9UPS7

    Protein attributes for TNS2 Gene

    Size:
    1409 amino acids
    Molecular mass:
    152580 Da
    Quaternary structure:
    • Interacts with AXL. Interacts with SYK; leading to its phosphorylation (PubMed:22019427).
    SequenceCaution:
    • Sequence=AAI29829.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI29830.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI31504.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA83027.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH56176.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNS2 Gene

    Alternative splice isoforms for TNS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNS2 Gene

Post-translational modifications for TNS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TNS2 Gene

Domains & Families for TNS2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNS2: view

No data available for UniProtKB/Swiss-Prot for TNS2 Gene

Function for TNS2 Gene

Molecular function for TNS2 Gene

UniProtKB/Swiss-Prot Function:
Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling.

Enzyme Numbers (IUBMB) for TNS2 Gene

Gene Ontology (GO) - Molecular Function for TNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0005515 protein binding IPI 16273093
GO:0016787 hydrolase activity IEA --
GO:0019900 kinase binding IPI 22019427
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TNS2: view
genes like me logo Genes that share phenotypes with TNS2: view

Animal Model Products

CRISPR Products

miRNA for TNS2 Gene

miRTarBase miRNAs that target TNS2

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNS2 Gene

Localization for TNS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNS2 Gene

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the end of actin stress fibers. Detected in cytoplasmic punctate bodies (PubMed:22019427). {ECO:0000269 PubMed:22019427}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNS2 gene
Compartment Confidence
plasma membrane 3
nucleus 3
cytosol 2
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA --
GO:0005925 focal adhesion IDA,IEA 16951145
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with TNS2: view

Pathways & Interactions for TNS2 Gene

genes like me logo Genes that share pathways with TNS2: view

Pathways by source for TNS2 Gene

3 Cell Signaling Technology pathways for TNS2 Gene

Gene Ontology (GO) - Biological Process for TNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0006470 protein dephosphorylation IEA --
GO:0008285 negative regulation of cell proliferation IMP 16951145
GO:0014850 response to muscle activity IEA --
GO:0019725 cellular homeostasis IEA --
genes like me logo Genes that share ontologies with TNS2: view

No data available for SIGNOR curated interactions for TNS2 Gene

Drugs & Compounds for TNS2 Gene

(4) Additional Compounds for TNS2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Hexadecanoyl-3-(11-eicosenoyl)-sn-glycerol
  • 1-Palmitoyl-3-eicosenoyl-sn-glycerol
  • DAG(16:0/0:0/20:1)
  • DAG(16:0/0:0/20:1n9)
  • DAG(16:0/0:0/20:1w9)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with TNS2: view

Transcripts for TNS2 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TNS2