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Aliases for TNS2 Gene

Aliases for TNS2 Gene

  • Tensin 2 2 3
  • TENC1 3 4 6
  • Tensin Like C1 Domain Containing Phosphatase (Tensin 2) 2 3
  • C1 Domain-Containing Phosphatase And Tensin Homolog 3 4
  • Tensin Like C1 Domain-Containing Phosphatase 2 3
  • Tensin-Like C1 Domain-Containing Phosphatase 3 4
  • KIAA1075 4 6
  • C1-TEN 3 4
  • C1TEN 3 6
  • EC 3.1.3.- 4
  • Tensin-2 3

External Ids for TNS2 Gene

Previous HGNC Symbols for TNS2 Gene

  • TENC1

Summaries for TNS2 Gene

Entrez Gene Summary for TNS2 Gene

  • The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNS2 Gene

TNS2 (Tensin 2) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and Adhesion. An important paralog of this gene is TNS1.

UniProtKB/Swiss-Prot for TNS2 Gene

  • Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling.

Gene Wiki entry for TNS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNS2 Gene

Genomics for TNS2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TNS2 Gene

Start:
53,046,969 bp from pter
End:
53,064,379 bp from pter
Size:
17,411 bases
Orientation:
Plus strand

Genomic View for TNS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNS2 Gene

No data available for Regulatory Elements for TNS2 Gene

Proteins for TNS2 Gene

  • Protein details for TNS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q63HR2-TNS2_HUMAN
    Recommended name:
    Tensin-2
    Protein Accession:
    Q63HR2
    Secondary Accessions:
    • A2VDF2
    • A2VDF3
    • A2VDI8
    • A5PKY4
    • Q2NL80
    • Q76MW6
    • Q7Z5T9
    • Q8NFF9
    • Q8NFG0
    • Q96P25
    • Q9NT29
    • Q9UPS7

    Protein attributes for TNS2 Gene

    Size:
    1409 amino acids
    Molecular mass:
    152580 Da
    Quaternary structure:
    • Interacts with AXL. Interacts with SYK; leading to its phosphorylation (PubMed:22019427).
    SequenceCaution:
    • Sequence=AAI29829.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI29830.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI31504.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA83027.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH56176.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNS2 Gene

    Alternative splice isoforms for TNS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNS2 Gene

Proteomics data for TNS2 Gene at MOPED

Post-translational modifications for TNS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TNS2 Gene

Domains for TNS2 Gene

Gene Families for TNS2 Gene

HGNC:
  • DUSPQ :Protein tyrosine phosphatases / Class I Cys-based PTPs : PTENs
  • SH2D :SH2 domain containing

Graphical View of Domain Structure for InterPro Entry

Q63HR2

UniProtKB/Swiss-Prot:

TNS2_HUMAN :
  • Q63HR2
Domain:
  • Contains 1 C2 tensin-type domain.
  • Contains 1 phosphatase tensin-type domain.
  • Contains 1 SH2 domain.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with TNS2: view

No data available for Suggested Antigen Peptide Sequences for TNS2 Gene

Function for TNS2 Gene

Molecular function for TNS2 Gene

UniProtKB/Swiss-Prot Function:
Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling.

Enzyme Numbers (IUBMB) for TNS2 Gene

Gene Ontology (GO) - Molecular Function for TNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0005515 protein binding IPI 16273093
GO:0019900 kinase binding IPI 22019427
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TNS2: view
genes like me logo Genes that share phenotypes with TNS2: view

miRNA for TNS2 Gene

miRTarBase miRNAs that target TNS2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNS2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TNS2 Gene

Localization for TNS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNS2 Gene

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the end of actin stress fibers. Detected in cytoplasmic punctate bodies (PubMed:22019427). {ECO:0000269 PubMed:22019427}.

Gene Ontology (GO) - Cellular Components for TNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005925 focal adhesion IDA 16951145
genes like me logo Genes that share ontologies with TNS2: view

No data available for Subcellular locations from COMPARTMENTS for TNS2 Gene

Pathways for TNS2 Gene

genes like me logo Genes that share pathways with TNS2: view

Pathways by source for TNS2 Gene

3 Cell Signaling Technology pathways for TNS2 Gene

Gene Ontology (GO) - Biological Process for TNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0008285 negative regulation of cell proliferation IMP 16951145
GO:0014850 response to muscle activity IEA --
GO:0016311 dephosphorylation IEA --
GO:0019725 cellular homeostasis IEA --
genes like me logo Genes that share ontologies with TNS2: view

Transcripts for TNS2 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNS2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNS2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: -
SP6: - - - - - -
SP7:
SP8:
SP9: -
SP10:
SP11: -
SP12:
SP13:
SP14: - - -

ExUns: 18b ^ 19a · 19b ^ 20a · 20b · 20c · 20d ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b · 25c · 25d ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c ^ 30 ^ 31
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - - - - - - - - - - - -
SP5: - - - - -
SP6:
SP7: -
SP8: - -
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:

Relevant External Links for TNS2 Gene

GeneLoc Exon Structure for
TNS2
ECgene alternative splicing isoforms for
TNS2

Expression for TNS2 Gene

mRNA expression in normal human tissues for TNS2 Gene

Protein differential expression in normal tissues for TNS2 Gene

This gene is overexpressed in Adipocyte (39.0) and Gallbladder (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TNS2 Gene

mRNA Expression by UniProt/SwissProt for TNS2 Gene

Q63HR2-TNS2_HUMAN
Tissue specificity: Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and small intestine.
genes like me logo Genes that share expressions with TNS2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Expression partners for TNS2 Gene

Orthologs for TNS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNS2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TENC1 35
  • 89.24 (n)
  • 93.04 (a)
TENC1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TENC1 35
  • 86.3 (n)
  • 90.08 (a)
TENC1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tenc1 35
  • 86.28 (n)
  • 90.64 (a)
Tenc1 16
Tenc1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TENC1 35
  • 99.53 (n)
  • 99.57 (a)
TENC1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tenc1 35
  • 86.32 (n)
  • 90.56 (a)
lizard
(Anolis carolinensis)
Reptilia TENC1 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tenc1 35
  • 60.15 (n)
  • 59.45 (a)
zebrafish
(Danio rerio)
Actinopterygii tenc1a 35
  • 60.96 (n)
  • 60.74 (a)
tenc1a 36
  • 43 (a)
OneToMany
tenc1b 36
  • 40 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta by 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-163 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for TNS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TNS2 Gene

ENSEMBL:
Gene Tree for TNS2 (if available)
TreeFam:
Gene Tree for TNS2 (if available)

Paralogs for TNS2 Gene

Paralogs for TNS2 Gene

genes like me logo Genes that share paralogs with TNS2: view

Variants for TNS2 Gene

Sequence variations from dbSNP and Humsavar for TNS2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2280446 -- 53,058,168(-) TGACT(A/G)TGCCG intron-variant
rs2293061 -- 53,058,954(-) CAGCT(C/G)TCGGG intron-variant
rs10431493 -- 53,062,835(+) ACTGT(C/T)GGGGA intron-variant
rs11170389 -- 53,058,065(+) CATCA(C/G)CCTGG missense, reference
rs11170390 -- 53,061,633(+) AAGGC(A/G)GTGAG intron-variant

Relevant External Links for TNS2 Gene

HapMap Linkage Disequilibrium report
TNS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TNS2 Gene

Disorders for TNS2 Gene

No disorders were found for TNS2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TNS2 Gene

Publications for TNS2 Gene

  1. C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration. (PMID: 15817639) Hafizi S. … Dahlbaeck B. (FASEB J. 2005) 3 4
  2. The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2. (PMID: 22019427) Moon K.D. … Geahlen R.L. (Biochim. Biophys. Acta 2012) 3 4
  3. Tensin 2 modulates cell contractility in 3D collagen gels through the RhoGAP DLC1. (PMID: 20069572) Clark K. … Critchley D.R. (J. Cell. Biochem. 2010) 3 23
  4. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 3 4
  5. Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration. (PMID: 11792844) Chen H. … Lo S.H. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4

Products for TNS2 Gene

Sources for TNS2 Gene

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