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Aliases for TNS2 Gene

Aliases for TNS2 Gene

  • Tensin 2 2 3 5
  • Tensin Like C1 Domain Containing Phosphatase (Tensin 2) 2 3
  • C1 Domain-Containing Phosphatase And Tensin Homolog 3 4
  • Tensin-Like C1 Domain-Containing Phosphatase 3 4
  • C1-TEN 3 4
  • TENC1 3 4
  • Tensin Like C1 Domain-Containing Phosphatase 2
  • EC 3.1.3.- 4
  • Tensin-2 3
  • KIAA1075 4
  • C1TEN 3

External Ids for TNS2 Gene

Previous HGNC Symbols for TNS2 Gene

  • TENC1

Summaries for TNS2 Gene

Entrez Gene Summary for TNS2 Gene

  • The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNS2 Gene

TNS2 (Tensin 2) is a Protein Coding gene. Among its related pathways are Adhesion and Cytoskeletal Signaling. GO annotations related to this gene include kinase binding and phosphoprotein phosphatase activity. An important paralog of this gene is TNS1.

UniProtKB/Swiss-Prot for TNS2 Gene

  • Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling.

Gene Wiki entry for TNS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNS2 Gene

Genomics for TNS2 Gene

Regulatory Elements for TNS2 Gene

Enhancers for TNS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F053043 0.6 FANTOM5 ENCODE 18.7 +2.6 2644 12.0 MLX DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC PPARGC1A MEF2D SSRP1 LOC283335 EIF4B TNS2 ENSG00000257500 LOC105378250 HOXC6 HOXC9 HOXC4 HOXC8 IGFBP6
GH12F053215 1 FANTOM5 ENCODE 8.9 +174.0 173955 10.1 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A ZNF2 ZNF207 ZNF143 MAP3K12 PFDN5 IGFBP6 ENSG00000257500 LOC105378250 ENSG00000260470 RARG TNS2 SP1 C12orf10
GH12F053060 0.9 Ensembl ENCODE 8.8 +20.0 19960 13.5 HDGF PKNOX1 MLX ARID4B SIN3A YBX1 DMAP1 ZNF48 ZNF2 SLC30A9 AAAS LOC100652999 IGFBP6 SOAT2 ZNF740 ITGB7 RNU6-333P ESPL1 PFDN5 C12orf10
GH12F052991 1.2 Ensembl ENCODE 8.8 -54.3 -54252 2.6 TBP SREBF2 ARID4B DMAP1 RAD21 RARA ZNF121 SCRT2 FOS SMARCC1 EIF4B KRT18 TNS2 SPRYD3 KRT8
GH12F053038 0.5 ENCODE 5 -8.0 -7963 1.4 PAF1 CTCF ZNF654 RAD21 NR2F2 ZFP69B ZNF121 SMC3 PRDM1 ZZZ3 EIF4B IGFBP6 PFDN5 LOC283335 SOAT2 C12orf10 TNS2 ENSG00000257475
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TNS2 on UCSC Golden Path with GeneCards custom track

Promoters for TNS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000430777 131 2201 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766

Genomic Location for TNS2 Gene

Chromosome:
12
Start:
53,046,969 bp from pter
End:
53,064,379 bp from pter
Size:
17,411 bases
Orientation:
Plus strand

Genomic View for TNS2 Gene

Genes around TNS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNS2 Gene

Proteins for TNS2 Gene

  • Protein details for TNS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q63HR2-TNS2_HUMAN
    Recommended name:
    Tensin-2
    Protein Accession:
    Q63HR2
    Secondary Accessions:
    • A2VDF2
    • A2VDF3
    • A2VDI8
    • A5PKY4
    • Q2NL80
    • Q76MW6
    • Q7Z5T9
    • Q8NFF9
    • Q8NFG0
    • Q96P25
    • Q9NT29
    • Q9UPS7

    Protein attributes for TNS2 Gene

    Size:
    1409 amino acids
    Molecular mass:
    152580 Da
    Quaternary structure:
    • Interacts with AXL. Interacts with SYK; leading to its phosphorylation (PubMed:22019427).
    SequenceCaution:
    • Sequence=AAI29829.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI29830.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI31504.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA83027.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH56176.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNS2 Gene

    Alternative splice isoforms for TNS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNS2 Gene

Post-translational modifications for TNS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TNS2 (tensin 2)
  • Abcam antibodies for TNS2

No data available for DME Specific Peptides for TNS2 Gene

Domains & Families for TNS2 Gene

Graphical View of Domain Structure for InterPro Entry

Q63HR2

UniProtKB/Swiss-Prot:

TNS2_HUMAN :
  • Contains 1 C2 tensin-type domain.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
Domain:
  • Contains 1 C2 tensin-type domain.
  • Contains 1 phosphatase tensin-type domain.
  • Contains 1 SH2 domain.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with TNS2: view

Function for TNS2 Gene

Molecular function for TNS2 Gene

UniProtKB/Swiss-Prot Function:
Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling.

Enzyme Numbers (IUBMB) for TNS2 Gene

Gene Ontology (GO) - Molecular Function for TNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0005515 protein binding IPI 16273093
GO:0016787 hydrolase activity IEA --
GO:0019900 kinase binding IPI 22019427
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TNS2: view
genes like me logo Genes that share phenotypes with TNS2: view

Animal Model Products

miRNA for TNS2 Gene

miRTarBase miRNAs that target TNS2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TNS2

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNS2 Gene

Localization for TNS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNS2 Gene

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the end of actin stress fibers. Detected in cytoplasmic punctate bodies (PubMed:22019427). {ECO:0000269 PubMed:22019427}.

Gene Ontology (GO) - Cellular Components for TNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA --
GO:0005925 focal adhesion IEA,IDA 16951145
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with TNS2: view

No data available for Subcellular locations from COMPARTMENTS for TNS2 Gene

Pathways & Interactions for TNS2 Gene

genes like me logo Genes that share pathways with TNS2: view

Pathways by source for TNS2 Gene

3 Cell Signaling Technology pathways for TNS2 Gene

Gene Ontology (GO) - Biological Process for TNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0006470 protein dephosphorylation IEA --
GO:0008285 negative regulation of cell proliferation IMP 16951145
GO:0014850 response to muscle activity IEA --
GO:0019725 cellular homeostasis IEA --
genes like me logo Genes that share ontologies with TNS2: view

No data available for SIGNOR curated interactions for TNS2 Gene

Drugs & Compounds for TNS2 Gene

(4) Additional Compounds for TNS2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with TNS2: view

Transcripts for TNS2 Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TNS2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNS2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: -
SP6: - - - - - -
SP7:
SP8:
SP9: -
SP10:
SP11: -
SP12:
SP13:
SP14: - - -

ExUns: 18b ^ 19a · 19b ^ 20a · 20b · 20c · 20d ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b · 25c · 25d ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c ^ 30 ^ 31
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - - - - - - - - - - - -
SP5: - - - - -
SP6:
SP7: -
SP8: - -
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:

Relevant External Links for TNS2 Gene

GeneLoc Exon Structure for
TNS2
ECgene alternative splicing isoforms for
TNS2

Expression for TNS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TNS2 Gene

This gene is overexpressed in Adipocyte (39.0) and Gallbladder (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TNS2 Gene



NURSA nuclear receptor signaling pathways regulating expression of TNS2 Gene:

TNS2

mRNA Expression by UniProt/SwissProt for TNS2 Gene:

Q63HR2-TNS2_HUMAN
Tissue specificity: Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and small intestine.
genes like me logo Genes that share expression patterns with TNS2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for TNS2 Gene

Orthologs for TNS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TENC1 34 35
  • 99.53 (n)
cow
(Bos Taurus)
Mammalia TENC1 34 35
  • 89.24 (n)
rat
(Rattus norvegicus)
Mammalia Tenc1 34
  • 86.32 (n)
dog
(Canis familiaris)
Mammalia TENC1 34 35
  • 86.3 (n)
mouse
(Mus musculus)
Mammalia Tenc1 34 35
  • 86.28 (n)
Tns2 16
lizard
(Anolis carolinensis)
Reptilia TENC1 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tenc1 34
  • 60.15 (n)
zebrafish
(Danio rerio)
Actinopterygii tenc1a 34 35
  • 60.96 (n)
tenc1b 35
  • 40 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta by 35
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-163 35
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
OneToMany
Species where no ortholog for TNS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TNS2 Gene

ENSEMBL:
Gene Tree for TNS2 (if available)
TreeFam:
Gene Tree for TNS2 (if available)

Paralogs for TNS2 Gene

Paralogs for TNS2 Gene

genes like me logo Genes that share paralogs with TNS2: view

Variants for TNS2 Gene

Sequence variations from dbSNP and Humsavar for TNS2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10431493 -- 53,062,835(+) ACTGT(C/T)GGGGA intron-variant
rs1043449 -- 53,064,054(+) GCCTG(C/T)TAAGT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs10437946 -- 53,048,612(+) CTCTC(C/T)AGTTA intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1048565 -- 53,064,805(-) TCCCC(A/G)TAACA downstream-variant-500B, utr-variant-3-prime
rs10747657 -- 53,045,825(+) CCCCC(A/G)CCCCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TNS2 Gene

Variant ID Type Subtype PubMed ID
dgv2644n54 CNV loss 21841781
esv28917 CNV loss 19812545
nsv1136150 CNV deletion 24896259
nsv470294 CNV loss 18288195
nsv517066 CNV loss 19592680
nsv558985 CNV loss 21841781
nsv558986 CNV loss 21841781

Variation tolerance for TNS2 Gene

Residual Variation Intolerance Score: 87.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.04; 90.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNS2 Gene

Disorders for TNS2 Gene

Relevant External Links for TNS2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNS2

No disorders were found for TNS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNS2 Gene

Publications for TNS2 Gene

  1. The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2. (PMID: 22019427) Moon K.D. … Geahlen R.L. (Biochim. Biophys. Acta 2012) 3 4 64
  2. Tensin 2 modulates cell contractility in 3D collagen gels through the RhoGAP DLC1. (PMID: 20069572) Clark K. … Critchley D.R. (J. Cell. Biochem. 2010) 3 22 64
  3. C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration. (PMID: 15817639) Hafizi S. … Dahlbaeck B. (FASEB J. 2005) 3 4 64
  4. Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration. (PMID: 11792844) Chen H. … Lo S.H. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4 64
  5. Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin. (PMID: 12470648) Hafizi S. … Dahlbaeck B. (Biochem. Biophys. Res. Commun. 2002) 3 4 64

Products for TNS2 Gene