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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNS1 Gene

protein-coding   GIFtS: 59
GCID: GC02M218664

Tensin 1

(Previous names: tensin, matrix-remodelling associated 6)
(Previous symbols: TNS, MXRA6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tensin 11 2     MST1222
TNS1 2 3 5     MST1272
MXRA61 2     MSTP1222
Matrix-Remodelling Associated 61 2     MSTP1272
tensin1     Matrix-Remodelling-Associated Protein 62
MST0912     tensin-12

External Ids:    HGNC: 119731   Entrez Gene: 71452   Ensembl: ENSG000000793087   OMIM: 6000765   UniProtKB: Q9HBL03   

Export aliases for TNS1 gene to outside databases

Previous GC identifers: GC02M218492 GC02M218375 GC02M210519


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNS1 Gene:
The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell
attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2)
domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain
II. A second transcript from this gene has been described, but its full length nature has not been determined.
(provided by RefSeq, Jul 2008)

GeneCards Summary for TNS1 Gene: 
TNS1 (tensin 1) is a protein-coding gene. Diseases associated with TNS1 include peanut allergic reaction, and bannayan-riley-ruvalcaba syndrome, and among its related super-pathways are Focal Adhesion. GO annotations related to this gene include protein binding and actin binding. An important paralog of this gene is PTEN.

UniProtKB/Swiss-Prot: TENS1_HUMAN, Q9HBL0
Function: Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and
in linking signal transduction pathways to the cytoskeleton

Gene Wiki entry for TNS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNS1 gene promoter:
         c-Fos   AP-1   ATF-2   LUN-1   c-Jun   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TNS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35-q36   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35-q36

TNS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNS1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M218664:  view genomic region     (about GC identifiers)

Start:
218,664,512 bp from pter      End:
218,867,718 bp from pter
Size:
203,207 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TENS1_HUMAN, Q9HBL0 (See protein sequence)
Recommended Name: Tensin-1  
Size: 1735 amino acids; 185701 Da
Subunit: Binds to actin filaments and interacts with phosphotyrosine-containing proteins. Interacts with STARD8
Subcellular location: Cell surface. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Localized at cell
periphery preferentially to fibrillar adhesions than focal adhesions. Translocates from the cell edge to cell
center in an ITGB1BP1-dependent manner
Secondary accessions: Q4ZG71

Explore the universe of human proteins at neXtProt for TNS1: NX_Q9HBL0

Explore proteomics data for TNS1 at MOPED 

Post-translational modifications:

  • UniProtKB: Rapidly cleaved by calpain II
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HBL0

  • TNS1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TNS1 Protein Expression
    REFSEQ proteins: NP_072174.3  
    ENSEMBL proteins: 
     ENSP00000171887   ENSP00000394171   ENSP00000408724   ENSP00000406016   ENSP00000405460  
     ENSP00000400383   ENSP00000308321   ENSP00000414704   ENSP00000395615   ENSP00000404477  
     ENSP00000411349   ENSP00000393925  

    Human Recombinant Protein Products for TNS1: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TNS1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0005925focal adhesion IDA--
    GO:0009986cell surface IEA--
    GO:0030055cell-substrate junction ----

    TNS1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SH2D: SH2 domain containing
    DUSPQ: Protein tyrosine phosphatases / Class I Cys-based PTPs : PTENs

    5/7 InterPro protein domains (see all 7):
     IPR014019 Phosphatase_tensin-typ
     IPR013625 PTB
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR006020 PTyr_interaction_dom
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q9HBL0

    ProtoNet protein and cluster: Q9HBL0

    3 Blocks protein domains:
    IPB000209 Subtilisin serine protease family (S8) signature
    IPB000980 SH2 domain signature
    IPB013625 Tensin phosphotyrosine-binding domain


    UniProtKB/Swiss-Prot: TENS1_HUMAN, Q9HBL0
    Similarity: Contains 1 C2 tensin-type domain
    Similarity: Contains 1 phosphatase tensin-type domain
    Similarity: Contains 1 SH2 domain


    TNS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TENS1_HUMAN, Q9HBL0
    Function: Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and
    in linking signal transduction pathways to the cytoskeleton

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI17190795
    GO:0046872metal ion binding ----
         
    TNS1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TNS1:
     Decreased Wnt reporter activit  Increased mitotic index 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tns1):
     behavior/neurological  cardiovascular system  cellular  immune system  renal/urinary system 
     reproductive system 

    TNS1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tns1tm1Efu for TNS1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TNS1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TNS1

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    SwitchGear 3'UTR luciferase reporter plasmidTNS1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TNS1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Integrin-mediated cell adhesion0.38


    1 BioSystems Pathway for TNS1
        Integrin-mediated cell adhesion


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TNS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/15 Interacting proteins for TNS1 (Q9HBL02, 3 ENSP000001718874) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KLF10Q131182, 3, ENSP000002854074MINT-8259241 I2D: score=2 STRING: ENSP00000285407
    OSGEPQ9NPF42, 3, ENSP000002065424MINT-8265301 I2D: score=2 STRING: ENSP00000206542
    CAPN2P176552, 3, ENSP000002950064MINT-8216416 I2D: score=2 STRING: ENSP00000295006
    NPHP1O152593, ENSP000003131694I2D: score=1 STRING: ENSP00000313169
    BCAR1P569453, ENSP000001623304I2D: score=1 STRING: ENSP00000162330
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007044cell-substrate junction assembly IEA--
    GO:0010761fibroblast migration IEA--
    GO:0035556intracellular signal transduction ----

    TNS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNS1 (TENS1)

    Search CenterWatch for drugs/clinical trials and news about TNS1 / TENS1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNS1 gene: 
    NM_022648.4  

    Unigene Cluster for TNS1:

    Tensin 1
    Hs.471381  [show with all ESTs]
    Unigene Representative Sequence: NM_022648
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000171887(uc002vgq.2 uc002vgr.2 uc002vgs.2 uc002vgt.2 uc010zjv.1 uc010fvk.1)
    ENST00000446688 ENST00000490566 ENST00000419504 ENST00000430930(uc010fvj.1)
    ENST00000480416 ENST00000495556 ENST00000446903 ENST00000479185(uc010fvi.1)
    ENST00000480665 ENST00000413554 ENST00000310858(uc002vgu.3) ENST00000453356
    ENST00000492338 ENST00000413280(uc002vgv.1) ENST00000439083 ENST00000423413
    ENST00000449814
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    hsa-miR-548j hsa-miR-26a-2* hsa-miR-520e hsa-miR-520f hsa-miR-1321 hsa-miR-642a hsa-miR-4272 hsa-miR-106a
    SwitchGear 3'UTR luciferase reporter plasmidTNS1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB209238.1 AF116610.1 AF172820.1 AF173897.1 AF176917.1 AK001785.2 AK057328.1 AK300345.1 
    AK309785.1 AK310169.1 AL117537.1 BC014042.2 BC033065.1 BC051304.1 BC063142.1 BC071905.1 
    BC107758.1 BC116187.1 BC116188.1 BC126910.1 BC140942.1 BC141869.1 

    22 DOTS entries:

    DT.65288302  DT.95254148  DT.409061  DT.91638643  DT.102842684  DT.120930058  DT.102842683  DT.95081881 
    DT.100722094  DT.91762106  DT.100010105  DT.40284680  DT.97855834  DT.100000225  DT.100787292  DT.120930045 
    DT.91762101  DT.92007742  DT.40312695  DT.424486  DT.448615  DT.91762112 

    24/115 AceView cDNA sequences (see all 115):

    BM704950 AW848727 AI696766 BF222588 BU734360 AL117537 AL708889 BP363359 
    BF913272 AW578368 AI609948 BM976854 BM701389 BQ949180 AA777636 AW272238 
    BP372749 BG818827 AI034472 AL706926 BG767153 CA314624 CA424834 CA443544 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for TNS1 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:                                      -     -     -     -                       -                                   -                                       
    SP2:                                                  -     -                                                           -                                       
    SP3:                                                                                                                                                            
    SP4:              -                       -     -     -     -                                                                                                   
    SP5:                                                                                                                                                            

    ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37
    SP1:  -                                                                                                               
    SP2:                                                                                                                  
    SP3:                                                                    -                                             
    SP4:                                                                                                                  
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for TNS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNS1 expression in normal human tissues (normalized intensities)      TNS1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGTATTGT
    TNS1 Expression
    About this image


    TNS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Wharton's jelly-derived stem cells
             umbilical cord reticulocytes   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             umbilical cord reticulocytes   
     
     Smooth Muscle (Muscoskeletal System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Blood Brain Barrier (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier

    See TNS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNS1

    SOURCE GeneReport for Unigene cluster: Hs.471381

    UniProtKB/Swiss-Prot: TENS1_HUMAN, Q9HBL0
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including TNS1: 
              Focal Adhesions in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TNS1 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tns11 , 5 tensin 11, 5 86.22(n)1
    89.91(a)1
      1 (38.17 cM)5
    219611  NM_027884.31  NP_082160.31 
     739102315 
    chicken
    (Gallus gallus)
    Aves TNS11 tensin 1 71.74(n)
    73.69(a)
      396439  NM_205455.1  NP_990786.1 
    lizard
    (Anolis carolinensis)
    Reptilia TNS16
    tensin 1
    60(a)
    1 ↔ 1
    1(89060824-89472941)
    African clawed frog
    (Xenopus laevis)
    Amphibia CB559530.12   -- 75.28(n)    CB559530.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570439422   -- 77.78(n)    57043942 
    fruit fly
    (Drosophila melanogaster)
    Insecta by6
    blistery
    29(a)
    1 → many
    3R(5353960-5358734)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-1636
    Protein TAG-163, isoform c
    23(a)
    1 → many
    I(5583405-5597332)


    ENSEMBL Gene Tree for TNS1 (if available)
    TreeFam Gene Tree for TNS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNS1 gene
    PTEN2  DNAJC62  TPTE2  TNS42  TNS32  TENC12  GAK2  TPTE22  
    7 SIMAP similar genes for TNS1 using alignment to 18 protein entries:     TENS1_HUMAN (see all proteins):
    DKFZp434G162    TNS3    GAK    TNS4    PTEN    PTEN2
    DKFZp434I2435

    TNS1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3348 SNPs in TNS1 are shown (see all 3348)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0480044
    A breast cancer sample4--see VAR_0480042 F L mis40--------
    rs1834015721,2
    --218664072(+) GAACAC/TTGGGA 1 -- ds50010--------
    rs1413667411,2
    --218664151(+) CCGCCA/GCTCAG 1 -- ds50010--------
    rs789004531,2
    F--218664268(+) CACTCG/TGGCCA 1 -- ds50011Minor allele frequency- T:0.07EA 120
    rs621837511,2
    C,F--218664368(+) ACCACG/ACAGAT 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1390399581,2
    --218664429(+) AAGCCA/CACCTG 1 -- ds50010--------
    rs1422468011,2
    --218664488(+) TGTCCA/GAACAA 1 -- ds50010--------
    rs1888477831,2
    --218664507(+) GATAAC/TGGCAC 1 -- ds50010--------
    rs1508144971,2
    C--218664525(+) TCTTTA/GACTTT 1 -- ut310--------
    rs1925378031,2
    --218664552(+) TACAAC/TGCATT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TNS1 (218664512 - 218867718 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for TNS1 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2664314CNV Deletion23128226
    esv2721471CNV Deletion23290073
    esv1006594CNV Deletion20482838
    esv2229410CNV Deletion18987734
    esv2670055CNV Deletion23128226
    esv2495817CNV Insertion19546169
    nsv460103CNV Loss19166990
    nsv460102CNV Loss19166990
    nsv527822CNV Loss19592680
    nsv528835CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600076    OMIM disorders: --

    6 diseases for TNS1:    About MalaCards
    peanut allergic reaction    bannayan-riley-ruvalcaba syndrome    ruvalcaba syndrome    obstructive lung disease
    cowden disease    kidney cancer

    3 diseases from the University of Copenhagen DISEASES database for TNS1:
    Cowden disease     Cancer     Bannayan-Riley-Ruvalcaba syndrome

    TNS1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TNS1
    Human Genome Epidemiology (HuGE) Navigator: TNS1 (3 documents)

    Export disorders for TNS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNS1 gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with TNS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations. (PubMed id 16953426)1, 4, 9 Beaty T.H....Scott A.F. (2006)
    2. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PubMed id 21998595)1, 4 N'Diaye A....Haiman C.A. (2011)
    3. Genome-wide association study identifies five loci as sociated with lung function. (PubMed id 20010834)1, 4 Repapi E....Rudnicka A.R. (2010)
    4. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    5. Molecular characterization of human tensin. (PubMed id 11023826)1, 2 Chen H.... Lo S.H. (2000)
    6. Genome-wide joint meta-analysis of SNP and SNP-by-smok ing interaction identifies novel loci for pulmonary function. (PubMed id 23284291)1 Hancock D.B....London S.J. (2012)
    7. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    8. Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effec ts on lung function. (PubMed id 21965014)1 Soler Artigas M....Tobin M.D. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Identification of the human testis protein phosphatase 1 interactome. (PubMed id 21382349)1 Fardilha M....Silva E.F. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7145 HGNC: 11973 AceView: TNS Ensembl:ENSG00000079308 euGenes: HUgn7145
    ECgene: TNS1 H-InvDB: TNS1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TNS1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNS1 gene:
    Search GeneIP for patents involving TNS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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