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Aliases for TNS1 Gene

Aliases for TNS1 Gene

  • Tensin 1 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 155 2 3
  • Matrix-Remodelling Associated 6 2 3
  • TNS 3 4
  • Matrix-Remodelling-Associated Protein 6 3
  • PPP1R155 3
  • Tensin-1 3
  • MSTP091 3
  • MSTP122 3
  • MSTP127 3
  • Tensin 2
  • MST091 3
  • MST122 3
  • MST127 3
  • MXRA6 3

External Ids for TNS1 Gene

Previous HGNC Symbols for TNS1 Gene

  • TNS
  • MXRA6

Previous GeneCards Identifiers for TNS1 Gene

  • GC02M218492
  • GC02M218375
  • GC02M218664
  • GC02M210519

Summaries for TNS1 Gene

Entrez Gene Summary for TNS1 Gene

  • The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

GeneCards Summary for TNS1 Gene

TNS1 (Tensin 1) is a Protein Coding gene. Diseases associated with TNS1 include Bannayan-Riley-Ruvalcaba Syndrome and Nut Allergy. Among its related pathways are Integrin Pathway and Focal Adhesion. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is TNS3.

UniProtKB/Swiss-Prot for TNS1 Gene

  • Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.

Gene Wiki entry for TNS1 Gene

Additional gene information for TNS1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNS1 Gene

Genomics for TNS1 Gene

GeneHancer (GH) Regulatory Elements for TNS1 Gene

Promoters and enhancers for TNS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I217939 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 576.6 +61.0 61026 5.5 HDGF ARID4B DMAP1 ZNF48 YY1 GLIS2 SP3 RXRA SP5 MIER2 TNS1 GC02P217941 LOC105373878 CXCR2 GC02P217959
GH02I217897 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 561.8 +100.5 100491 9.9 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 FOS TNS1 MIR6809 SLC11A1 LOC105373878 RUFY4 PNKD ARPC2 TMBIM1 GC02P217941
GH02I217999 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 550.8 -1.3 -1260 9.2 STAT1 MAZ ZNF189 MIER2 REST ATF2 SP1 JUND POLR2A CREB1 TNS1 RUFY4
GH02I217845 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 19.5 +150.2 150233 15.3 ZSCAN4 KLF17 RCOR1 FOS EGR2 MCM3 ZNF398 ZFP69B NFIC GLIS1 USP37 TNS1 AAMP LOC105373878 BCS1L CNOT9 PLCD4 PNKD ARPC2 GC02P217871
GH02I217926 Enhancer 1.9 VISTA FANTOM5 Ensembl ENCODE dbSUPER 11.4 +70.3 70299 12.6 CTCF KLF1 USF1 SIN3A MAX RAD21 RARA YY1 LCORL POLR2A SLC11A1 LOC105373878 TNS1 PNKD ARPC2 TMBIM1 GC02P217941 MIR6809
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TNS1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNS1 gene promoter:

Genomic Locations for TNS1 Gene

Genomic Locations for TNS1 Gene
chr2:217,799,789-218,002,995
(GRCh38/hg38)
Size:
203,207 bases
Orientation:
Minus strand
chr2:218,664,512-218,867,718
(GRCh37/hg19)

Genomic View for TNS1 Gene

Genes around TNS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNS1 Gene

Proteins for TNS1 Gene

  • Protein details for TNS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBL0-TENS1_HUMAN
    Recommended name:
    Tensin-1
    Protein Accession:
    Q9HBL0
    Secondary Accessions:
    • Q4ZG71
    • Q6IPI5

    Protein attributes for TNS1 Gene

    Size:
    1735 amino acids
    Molecular mass:
    185701 Da
    Quaternary structure:
    • Binds to actin filaments and interacts with phosphotyrosine-containing proteins. Interacts with STARD8.

    Alternative splice isoforms for TNS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNS1 Gene

Post-translational modifications for TNS1 Gene

No data available for DME Specific Peptides for TNS1 Gene

Domains & Families for TNS1 Gene

Suggested Antigen Peptide Sequences for TNS1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNS1: view

No data available for UniProtKB/Swiss-Prot for TNS1 Gene

Function for TNS1 Gene

Molecular function for TNS1 Gene

UniProtKB/Swiss-Prot Function:
Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.

Phenotypes From GWAS Catalog for TNS1 Gene

Gene Ontology (GO) - Molecular Function for TNS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 17190795
genes like me logo Genes that share ontologies with TNS1: view
genes like me logo Genes that share phenotypes with TNS1: view

Animal Models for TNS1 Gene

MGI Knock Outs for TNS1:

miRNA for TNS1 Gene

miRTarBase miRNAs that target TNS1

Clone Products

  • Addgene plasmids for TNS1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNS1 Gene

Localization for TNS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNS1 Gene

Cell surface. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Localized at cell periphery preferentially to fibrillar adhesions than focal adhesions. Translocates from the cell edge to cell center in an ITGB1BP1-dependent manner.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNS1 gene
Compartment Confidence
cytoskeleton 4
nucleus 4
cytosol 3
plasma membrane 2
extracellular 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TNS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005925 focal adhesion IDA 11023826
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with TNS1: view

Pathways & Interactions for TNS1 Gene

genes like me logo Genes that share pathways with TNS1: view

Pathways by source for TNS1 Gene

1 BioSystems pathway for TNS1 Gene
1 Qiagen pathway for TNS1 Gene

Gene Ontology (GO) - Biological Process for TNS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007044 cell-substrate junction assembly IEA --
GO:0010761 fibroblast migration IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with TNS1: view

No data available for SIGNOR curated interactions for TNS1 Gene

Drugs & Compounds for TNS1 Gene

No Compound Related Data Available

Transcripts for TNS1 Gene

Unigene Clusters for TNS1 Gene

Tensin 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for TNS1

Alternative Splicing Database (ASD) splice patterns (SP) for TNS1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - - - -
SP2: - - -
SP3:
SP4: - - - - -
SP5:
SP6: - - - -
SP7: - - - -
SP8:
SP9: - - -
SP10:
SP11:
SP12:
SP13:

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for TNS1 Gene

GeneLoc Exon Structure for
TNS1
ECgene alternative splicing isoforms for
TNS1

Expression for TNS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNS1 Gene

This gene is overexpressed in Artery - Tibial (x5.8) and Artery - Aorta (x4.5).

Protein differential expression in normal tissues from HIPED for TNS1 Gene

This gene is overexpressed in Urinary Bladder (12.2), Prostate (8.2), and Gallbladder (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TNS1 Gene



Protein tissue co-expression partners for TNS1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TNS1 Gene:

TNS1

SOURCE GeneReport for Unigene cluster for TNS1 Gene:

Hs.471381

mRNA Expression by UniProt/SwissProt for TNS1 Gene:

Q9HBL0-TENS1_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for TNS1 Gene

  • Heart(4.7)
  • Blood(4.5)
  • Liver(4.5)
  • Skin(4.4)
  • Nervous system(3.5)
  • Lung(3.4)
  • Muscle(3.3)
  • Kidney(3.1)
  • Intestine(3)
  • Thyroid gland(2.6)
  • Pancreas(2.5)
  • Stomach(2.5)
  • Eye(2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with TNS1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TNS1 Gene

Orthologs for TNS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNS1 33 34
  • 97.68 (n)
dog
(Canis familiaris)
Mammalia TNS1 33 34
  • 89.48 (n)
cow
(Bos Taurus)
Mammalia TNS1 33 34
  • 89.36 (n)
mouse
(Mus musculus)
Mammalia Tns1 33 16 34
  • 86.14 (n)
rat
(Rattus norvegicus)
Mammalia Tns1 33
  • 85.86 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TNS1 34
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNS1 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNS1 33
  • 71.76 (n)
lizard
(Anolis carolinensis)
Reptilia TNS1 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tns1 33
  • 66.94 (n)
zebrafish
(Danio rerio)
Actinopterygii tns1 33 34
  • 62.07 (n)
TNS1 (2 of 2) 34
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta by 34
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-163 34
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2758 33
Species where no ortholog for TNS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TNS1 Gene

ENSEMBL:
Gene Tree for TNS1 (if available)
TreeFam:
Gene Tree for TNS1 (if available)

Paralogs for TNS1 Gene

Variants for TNS1 Gene

Sequence variations from dbSNP and Humsavar for TNS1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
VAR_048004 A breast cancer sample p.Phe1093Leu
rs1000012011 -- 217,951,666(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000048965 -- 217,967,575(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000061527 -- 217,950,764(-) T/G genic_upstream_transcript_variant, intron_variant
rs1000069290 -- 217,911,105(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TNS1 Gene

Variant ID Type Subtype PubMed ID
dgv4174n100 CNV gain 25217958
dgv4175n100 CNV gain 25217958
esv1006594 CNV deletion 20482838
esv2229410 CNV deletion 18987734
esv2495817 CNV insertion 19546169
esv2664314 CNV deletion 23128226
esv2670055 CNV deletion 23128226
esv2721471 CNV deletion 23290073
esv2760585 CNV gain 21179565
esv3594325 CNV gain 21293372
esv3594326 CNV loss 21293372
nsv460102 CNV loss 19166990
nsv460103 CNV loss 19166990
nsv470517 CNV loss 18288195
nsv475517 CNV novel sequence insertion 20440878
nsv527822 CNV loss 19592680
nsv528835 CNV loss 19592680
nsv584486 CNV loss 21841781
nsv584487 CNV loss 21841781
nsv834541 CNV loss 17160897
nsv954834 CNV deletion 24416366

Variation tolerance for TNS1 Gene

Residual Variation Intolerance Score: 96.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.41; 98.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNS1 Gene

Human Gene Mutation Database (HGMD)
TNS1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNS1 Gene

Disorders for TNS1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TNS1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
bannayan-riley-ruvalcaba syndrome
  • brrs
nut allergy
  • allergy to nuts
proteus syndrome
  • gigantism, partial, of hands and feet, nevi, hemihypertrophy, and macrocephaly
cowden disease
  • cs
- elite association - COSMIC cancer census association via MalaCards
Search TNS1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TNS1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TNS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNS1 Gene

Publications for TNS1 Gene

  1. Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations. (PMID: 16953426) Beaty TH … Scott AF (Human genetics 2006) 3 22 44 58
  2. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PMID: 21998595) N'Diaye A … Haiman CA (PLoS genetics 2011) 3 44 58
  3. Genome-wide association study identifies five loci associated with lung function. (PMID: 20010834) Repapi E … Tobin MD (Nature genetics 2010) 3 44 58
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
  5. Molecular characterization of human tensin. (PMID: 11023826) Chen H … Lo SH (The Biochemical journal 2000) 3 4 58

Products for TNS1 Gene

  • Addgene plasmids for TNS1

Sources for TNS1 Gene

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