Aliases for TNS1 Gene
External Ids for TNS1 Gene
Previous HGNC Symbols for TNS1 Gene
Previous GeneCards Identifiers for TNS1 Gene
The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
GeneCards Summary for TNS1 Gene
TNS1 (Tensin 1) is a Protein Coding gene. Diseases associated with TNS1 include Bannayan-Riley-Ruvalcaba Syndrome and Cowden Syndrome 1. Among its related pathways are Focal Adhesion and Integrin Pathway. GO annotations related to this gene include poly(A) RNA binding and actin binding. An important paralog of this gene is TNS3.
UniProtKB/Swiss-Prot for TNS1 Gene
Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.