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Aliases for TNS1 Gene

Aliases for TNS1 Gene

  • Tensin 1 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 155 2 3
  • Matrix-Remodelling Associated 6 2 3
  • TNS 3 4
  • Matrix-Remodelling-Associated Protein 6 3
  • PPP1R155 3
  • Tensin-1 3
  • MSTP091 3
  • MSTP122 3
  • MSTP127 3
  • Tensin 2
  • MST091 3
  • MST122 3
  • MST127 3
  • MXRA6 3

External Ids for TNS1 Gene

Previous HGNC Symbols for TNS1 Gene

  • TNS
  • MXRA6

Previous GeneCards Identifiers for TNS1 Gene

  • GC02M218492
  • GC02M218375
  • GC02M218664
  • GC02M210519

Summaries for TNS1 Gene

Entrez Gene Summary for TNS1 Gene

  • The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

GeneCards Summary for TNS1 Gene

TNS1 (Tensin 1) is a Protein Coding gene. Diseases associated with TNS1 include Bannayan-Riley-Ruvalcaba Syndrome and Cowden Syndrome 1. Among its related pathways are Focal Adhesion and Integrin Pathway. GO annotations related to this gene include poly(A) RNA binding and actin binding. An important paralog of this gene is TNS3.

UniProtKB/Swiss-Prot for TNS1 Gene

  • Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.

Gene Wiki entry for TNS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNS1 Gene

Genomics for TNS1 Gene

Regulatory Elements for TNS1 Gene

Enhancers for TNS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F217939 1.4 FANTOM5 ENCODE 26.6 +61.0 61026 5.5 MLX ARID4B FEZF1 DMAP1 ZNF48 YY1 GLIS2 ZNF143 FOS SP5 TNS1 LOC105373878 CXCR2 GC02P217941 LOC105373879
GH02F217845 1.8 FANTOM5 Ensembl ENCODE 19.5 +150.2 150233 15.3 HDGF PKNOX1 MLX ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 LOC105373876 STK36 AAMP LOC105373878 BCS1L TNS1 CNOT9 ENSG00000231597 ENSG00000227021 RNF25
GH02F217926 2 VISTA FANTOM5 Ensembl ENCODE 11.4 +70.3 70300 12.6 HDAC1 FEZF1 RAD21 RARA YY1 ZNF335 FOS CEBPB REST NR2F2 SLC11A1 LOC105373878 TNS1 PNKD ARPC2 TMBIM1 GC02P217941 MIR6809
GH02F217897 1.7 FANTOM5 Ensembl ENCODE 11.8 +100.5 100492 9.9 PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 SLC30A9 ZNF143 SLC11A1 LOC105373878 TNS1 RUFY4 PNKD ARPC2 TMBIM1 MIR6809 GC02P217941
GH02F217797 1.3 FANTOM5 Ensembl ENCODE 11.1 +204.7 204695 2.6 PKNOX1 SAP130 MLX ZNF48 RARA ZNF316 POLR2A EED NFE2 MAFK LOC105373878 TNS1 DIRC3 ARPC2 GC02M217800 RPL7L1P9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNS1 on UCSC Golden Path with GeneCards custom track

Promoters for TNS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001661443 595 1601 CTCF SMARCA4 POLR2A

Genomic Location for TNS1 Gene

217,799,789 bp from pter
218,002,995 bp from pter
203,207 bases
Minus strand

Genomic View for TNS1 Gene

Genes around TNS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNS1 Gene

Proteins for TNS1 Gene

  • Protein details for TNS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q4ZG71
    • Q6IPI5

    Protein attributes for TNS1 Gene

    1735 amino acids
    Molecular mass:
    185701 Da
    Quaternary structure:
    • Binds to actin filaments and interacts with phosphotyrosine-containing proteins. Interacts with STARD8.

    Alternative splice isoforms for TNS1 Gene


neXtProt entry for TNS1 Gene

Post-translational modifications for TNS1 Gene

No data available for DME Specific Peptides for TNS1 Gene

Domains & Families for TNS1 Gene

Suggested Antigen Peptide Sequences for TNS1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C2 tensin-type domain.
  • Contains 1 C2 tensin-type domain.
  • Contains 1 phosphatase tensin-type domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with TNS1: view

Function for TNS1 Gene

Molecular function for TNS1 Gene

UniProtKB/Swiss-Prot Function:
Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.

Gene Ontology (GO) - Molecular Function for TNS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 17190795
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with TNS1: view
genes like me logo Genes that share phenotypes with TNS1: view

Animal Models for TNS1 Gene

MGI Knock Outs for TNS1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNS1 Gene

Localization for TNS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNS1 Gene

Cell surface. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Localized at cell periphery preferentially to fibrillar adhesions than focal adhesions. Translocates from the cell edge to cell center in an ITGB1BP1-dependent manner.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNS1 gene
Compartment Confidence
cytoskeleton 4
nucleus 4
cytosol 3
plasma membrane 2
extracellular 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TNS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005925 focal adhesion IEA,IDA 11023826
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with TNS1: view

Pathways & Interactions for TNS1 Gene

genes like me logo Genes that share pathways with TNS1: view

Pathways by source for TNS1 Gene

1 BioSystems pathway for TNS1 Gene
1 Qiagen pathway for TNS1 Gene

Gene Ontology (GO) - Biological Process for TNS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007044 cell-substrate junction assembly IEA --
GO:0010761 fibroblast migration IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with TNS1: view

No data available for SIGNOR curated interactions for TNS1 Gene

Transcripts for TNS1 Gene

Unigene Clusters for TNS1 Gene

Tensin 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNS1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - - - -
SP2: - - -
SP4: - - - - -
SP6: - - - -
SP7: - - - -
SP9: - - -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37
SP1: -
SP3: -
SP8: -

Relevant External Links for TNS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNS1 Gene

This gene is overexpressed in Artery - Tibial (x5.8) and Artery - Aorta (x4.5).

Protein differential expression in normal tissues from HIPED for TNS1 Gene

This gene is overexpressed in Urinary Bladder (12.2), Prostate (8.2), and Gallbladder (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TNS1 Gene

Protein tissue co-expression partners for TNS1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TNS1 Gene:


SOURCE GeneReport for Unigene cluster for TNS1 Gene:


mRNA Expression by UniProt/SwissProt for TNS1 Gene:

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with TNS1: view

Primer Products

Orthologs for TNS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNS1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TNS1 34 35
  • 97.68 (n)
(Canis familiaris)
Mammalia TNS1 34 35
  • 89.48 (n)
(Bos Taurus)
Mammalia TNS1 34 35
  • 89.36 (n)
(Mus musculus)
Mammalia Tns1 34 16 35
  • 86.14 (n)
(Rattus norvegicus)
Mammalia Tns1 34
  • 85.86 (n)
(Ornithorhynchus anatinus)
Mammalia TNS1 35
  • 79 (a)
(Monodelphis domestica)
Mammalia TNS1 35
  • 73 (a)
(Gallus gallus)
Aves TNS1 34
  • 71.76 (n)
(Anolis carolinensis)
Reptilia TNS1 35
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tns1 34
  • 66.94 (n)
(Danio rerio)
Actinopterygii tns1 34 35
  • 62.07 (n)
TNS1 (2 of 2) 35
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta by 35
  • 29 (a)
(Caenorhabditis elegans)
Secernentea tag-163 35
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2758 34
Species where no ortholog for TNS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TNS1 Gene

Gene Tree for TNS1 (if available)
Gene Tree for TNS1 (if available)

Paralogs for TNS1 Gene

Variants for TNS1 Gene

Sequence variations from dbSNP and Humsavar for TNS1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_048004 A breast cancer sample
rs1000978 -- 217,841,444(-) TTGTT(G/T)TGTTT intron-variant
rs1000979 -- 217,841,264(-) GCAGG(A/G)CATCG intron-variant, reference, missense
rs1000980 -- 217,841,225(-) TCTCC(A/G)CCGGC intron-variant, reference, missense
rs1004814 -- 217,847,583(-) GAAGC(A/G)ACTTC upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TNS1 Gene

Variant ID Type Subtype PubMed ID
nsv954834 CNV deletion 24416366
nsv834541 CNV loss 17160897
nsv584487 CNV loss 21841781
nsv584486 CNV loss 21841781
nsv528835 CNV loss 19592680
nsv527822 CNV loss 19592680
nsv475517 CNV novel sequence insertion 20440878
nsv470517 CNV loss 18288195
nsv460103 CNV loss 19166990
nsv460102 CNV loss 19166990
esv3594326 CNV loss 21293372
esv3594325 CNV gain 21293372
esv2760585 CNV gain 21179565
esv2721471 CNV deletion 23290073
esv2670055 CNV deletion 23128226
esv2664314 CNV deletion 23128226
esv2495817 CNV insertion 19546169
esv2229410 CNV deletion 18987734
esv1006594 CNV deletion 20482838
dgv4175n100 CNV gain 25217958
dgv4174n100 CNV gain 25217958

Variation tolerance for TNS1 Gene

Residual Variation Intolerance Score: 96.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.41; 98.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNS1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNS1 Gene

Disorders for TNS1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TNS1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bannayan-riley-ruvalcaba syndrome
  • bannayan-zonana syndrome
cowden syndrome 1
  • lhermitte-duclos syndrome
- elite association - COSMIC cancer census association via MalaCards
Search TNS1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TNS1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TNS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNS1 Gene

Publications for TNS1 Gene

  1. Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations. (PMID: 16953426) Beaty T.H. … Scott A.F. (Hum. Genet. 2006) 3 22 46 64
  2. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PMID: 21998595) N'Diaye A. … Haiman C.A. (PLoS Genet. 2011) 3 46 64
  3. Genome-wide association study identifies five loci associated with lung function. (PMID: 20010834) Repapi E. … Tobin M.D. (Nat. Genet. 2010) 3 46 64
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
  5. Molecular characterization of human tensin. (PMID: 11023826) Chen H. … Lo S.H. (Biochem. J. 2000) 3 4 64

Products for TNS1 Gene

Sources for TNS1 Gene

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