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Aliases for TNS1 Gene

Aliases for TNS1 Gene

  • Tensin 1 2 3 5
  • Matrix-Remodelling Associated 6 2 3
  • TNS 3 4
  • Protein Phosphatase 1, Regulatory Subunit 155 3
  • Matrix-Remodelling-Associated Protein 6 3
  • Regulatory Subunit 155 2
  • Protein Phosphatase 1 2
  • PPP1R155 3
  • MSTP091 3
  • MSTP122 3
  • MSTP127 3
  • Tensin 2
  • MST091 3
  • MST122 3
  • MST127 3
  • MXRA6 3

External Ids for TNS1 Gene

Previous HGNC Symbols for TNS1 Gene

  • TNS
  • MXRA6

Previous GeneCards Identifiers for TNS1 Gene

  • GC02M218492
  • GC02M218375
  • GC02M218664
  • GC02M210519

Summaries for TNS1 Gene

Entrez Gene Summary for TNS1 Gene

  • The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

GeneCards Summary for TNS1 Gene

TNS1 (Tensin 1) is a Protein Coding gene. Diseases associated with TNS1 include Cowden Disease. Among its related pathways are Focal Adhesion and Integrin Pathway. GO annotations related to this gene include poly(A) RNA binding and actin binding. An important paralog of this gene is TNS4.

UniProtKB/Swiss-Prot for TNS1 Gene

  • Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.

Gene Wiki entry for TNS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNS1 Gene

Genomics for TNS1 Gene

Regulatory Elements for TNS1 Gene

Enhancers for TNS1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TNS1 on UCSC Golden Path with GeneCards custom track

Promoters for TNS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TNS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TNS1 Gene

Chromosome:
2
Start:
217,799,789 bp from pter
End:
218,002,995 bp from pter
Size:
203,207 bases
Orientation:
Minus strand

Genomic View for TNS1 Gene

Genes around TNS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNS1 Gene

Proteins for TNS1 Gene

  • Protein details for TNS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBL0-TENS1_HUMAN
    Recommended name:
    Tensin-1
    Protein Accession:
    Q9HBL0
    Secondary Accessions:
    • Q4ZG71
    • Q6IPI5

    Protein attributes for TNS1 Gene

    Size:
    1735 amino acids
    Molecular mass:
    185701 Da
    Quaternary structure:
    • Binds to actin filaments and interacts with phosphotyrosine-containing proteins. Interacts with STARD8.

    Alternative splice isoforms for TNS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNS1 Gene

Proteomics data for TNS1 Gene at MOPED

Post-translational modifications for TNS1 Gene

No data available for DME Specific Peptides for TNS1 Gene

Domains & Families for TNS1 Gene

Suggested Antigen Peptide Sequences for TNS1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HBL0

UniProtKB/Swiss-Prot:

TENS1_HUMAN :
  • Contains 1 C2 tensin-type domain.
Domain:
  • Contains 1 C2 tensin-type domain.
  • Contains 1 phosphatase tensin-type domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with TNS1: view

Function for TNS1 Gene

Molecular function for TNS1 Gene

UniProtKB/Swiss-Prot Function:
Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.

Gene Ontology (GO) - Molecular Function for TNS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with TNS1: view
genes like me logo Genes that share phenotypes with TNS1: view

Animal Models for TNS1 Gene

MGI Knock Outs for TNS1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNS1 Gene

Localization for TNS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNS1 Gene

Cell surface. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Localized at cell periphery preferentially to fibrillar adhesions than focal adhesions. Translocates from the cell edge to cell center in an ITGB1BP1-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNS1 Gene COMPARTMENTS Subcellular localization image for TNS1 gene
Compartment Confidence
cytoskeleton 4
nucleus 4
cytosol 3
plasma membrane 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TNS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0030055 cell-substrate junction IEA --
genes like me logo Genes that share ontologies with TNS1: view

Pathways & Interactions for TNS1 Gene

genes like me logo Genes that share pathways with TNS1: view

Pathways by source for TNS1 Gene

1 BioSystems pathway for TNS1 Gene
1 Qiagen pathway for TNS1 Gene

Gene Ontology (GO) - Biological Process for TNS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010761 fibroblast migration IEA --
genes like me logo Genes that share ontologies with TNS1: view

No data available for SIGNOR curated interactions for TNS1 Gene

Drugs & Compounds for TNS1 Gene

No Compound Related Data Available

Transcripts for TNS1 Gene

Unigene Clusters for TNS1 Gene

Tensin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNS1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - - - -
SP2: - - -
SP3:
SP4: - - - - -
SP5:
SP6: - - - -
SP7: - - - -
SP8:
SP9: - - -
SP10:
SP11:
SP12:
SP13:

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for TNS1 Gene

GeneLoc Exon Structure for
TNS1
ECgene alternative splicing isoforms for
TNS1

Expression for TNS1 Gene

mRNA expression in normal human tissues for TNS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNS1 Gene

This gene is overexpressed in Artery - Tibial (x5.8) and Artery - Aorta (x4.5).

Protein differential expression in normal tissues from HIPED for TNS1 Gene

This gene is overexpressed in Urinary Bladder (12.2), Prostate (8.2), and Gallbladder (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNS1 Gene



SOURCE GeneReport for Unigene cluster for TNS1 Gene Hs.471381

mRNA Expression by UniProt/SwissProt for TNS1 Gene

Q9HBL0-TENS1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with TNS1: view

Protein tissue co-expression partners for TNS1 Gene

- Elite partner

Primer Products

Orthologs for TNS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TNS1 35
  • 89.36 (n)
  • 93.16 (a)
TNS1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNS1 35
  • 89.48 (n)
  • 93.43 (a)
TNS1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tns1 35
  • 86.14 (n)
  • 89.8 (a)
Tns1 16
Tns1 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TNS1 35
  • 97.68 (n)
  • 97.46 (a)
TNS1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tns1 35
  • 85.86 (n)
  • 89.03 (a)
oppossum
(Monodelphis domestica)
Mammalia TNS1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNS1 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNS1 35
  • 71.76 (n)
  • 73.52 (a)
lizard
(Anolis carolinensis)
Reptilia TNS1 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tns1 35
  • 66.94 (n)
  • 68.17 (a)
zebrafish
(Danio rerio)
Actinopterygii tns1 35
  • 62.07 (n)
  • 61.3 (a)
tns1 36
  • 53 (a)
OneToMany
TNS1 (2 of 2) 36
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta by 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-163 36
  • 26 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2758 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToMany
Species with no ortholog for TNS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TNS1 Gene

ENSEMBL:
Gene Tree for TNS1 (if available)
TreeFam:
Gene Tree for TNS1 (if available)

Paralogs for TNS1 Gene

Paralogs for TNS1 Gene

genes like me logo Genes that share paralogs with TNS1: view

Variants for TNS1 Gene

Sequence variations from dbSNP and Humsavar for TNS1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs11680854 - 217,882,350(+) CCTTG(A/C)ATTTT nc-transcript-variant, reference, missense
rs3815849 - 217,848,746(+) TGGGC(A/G/T)GGACC nc-transcript-variant, reference, missense
rs3796033 - 217,848,559(+) CACTG(A/G)TGTTG nc-transcript-variant, reference, missense
rs3796028 - 217,830,379(+) GATCC(A/G)TCTTC intron-variant, nc-transcript-variant, reference, missense
rs2571445 - 217,818,431(-) TCGGC(C/T)GGCGG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TNS1 Gene

Variant ID Type Subtype PubMed ID
nsv460102 CNV Loss 19166990
esv2495817 CNV Insertion 19546169
esv2229410 CNV Deletion 18987734
esv2664314 CNV Deletion 23128226
esv2721471 CNV Deletion 23290073
nsv470517 CNV Loss 18288195
nsv460103 CNV Loss 19166990
esv2670055 CNV Deletion 23128226
nsv834541 CNV Loss 17160897
nsv528835 CNV Loss 19592680
nsv875851 CNV Gain 21882294
nsv527822 CNV Loss 19592680
dgv4434n71 CNV Loss 21882294
esv1006594 CNV Deletion 20482838

Variation tolerance for TNS1 Gene

Residual Variation Intolerance Score: 96.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.41; 98.85% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TNS1 Gene

Disorders for TNS1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TNS1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cowden disease
  • dysplastic gangliocytoma of cerebellum
- elite association - COSMIC cancer census association via MalaCards
Search TNS1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TNS1

Genetic Association Database (GAD)
TNS1
Human Genome Epidemiology (HuGE) Navigator
TNS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNS1
genes like me logo Genes that share disorders with TNS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNS1 Gene

Publications for TNS1 Gene

  1. Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations. (PMID: 16953426) Beaty T.H. … Scott A.F. (Hum. Genet. 2006) 3 23 48 67
  2. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome. (PMID: 24728074) Leung K.K. … Jones R.B. (Mol. Cell Proteomics 2014) 3
  5. Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. (PMID: 24388013) Ferreira M.A. … Hopper J.L. (J. Allergy Clin. Immunol. 2013) 3

Products for TNS1 Gene

Sources for TNS1 Gene

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