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Aliases for TNS1 Gene

Aliases for TNS1 Gene

  • Tensin 1 2 3
  • TNS 3 4 6
  • Matrix-Remodelling Associated 6 2 3
  • Protein Phosphatase 1, Regulatory Subunit 155 3
  • Matrix-Remodelling-Associated Protein 6 3
  • Regulatory Subunit 155 2
  • Protein Phosphatase 1 2
  • PPP1R155 3
  • Tensin-1 3
  • MSTP091 3
  • MSTP122 3
  • MSTP127 3
  • Tensin 2
  • MST091 3
  • MST122 3
  • MST127 3
  • MXRA6 3

External Ids for TNS1 Gene

Previous HGNC Symbols for TNS1 Gene

  • TNS
  • MXRA6

Previous GeneCards Identifiers for TNS1 Gene

  • GC02M218492
  • GC02M218375
  • GC02M218664
  • GC02M210519

Summaries for TNS1 Gene

Entrez Gene Summary for TNS1 Gene

  • The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. A second transcript from this gene has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNS1 Gene

TNS1 (Tensin 1) is a Protein Coding gene. Diseases associated with TNS1 include bannayan-riley-ruvalcaba syndrome and ruvalcaba syndrome. Among its related pathways are Integrin Pathway and Focal adhesion. GO annotations related to this gene include actin binding. An important paralog of this gene is TNS4.

UniProtKB/Swiss-Prot for TNS1 Gene

  • Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.

Gene Wiki entry for TNS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNS1 Gene

Genomics for TNS1 Gene

Regulatory Elements for TNS1 Gene

Genomic Location for TNS1 Gene

Start:
217,799,789 bp from pter
End:
218,002,995 bp from pter
Size:
203,207 bases
Orientation:
Minus strand

Genomic View for TNS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNS1 Gene

Proteins for TNS1 Gene

  • Protein details for TNS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBL0-TENS1_HUMAN
    Recommended name:
    Tensin-1
    Protein Accession:
    Q9HBL0
    Secondary Accessions:
    • Q4ZG71
    • Q6IPI5

    Protein attributes for TNS1 Gene

    Size:
    1735 amino acids
    Molecular mass:
    185701 Da
    Quaternary structure:
    • Binds to actin filaments and interacts with phosphotyrosine-containing proteins. Interacts with STARD8.

    Alternative splice isoforms for TNS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNS1 Gene

Proteomics data for TNS1 Gene at MOPED

Post-translational modifications for TNS1 Gene

No data available for DME Specific Peptides for TNS1 Gene

Domains for TNS1 Gene

Gene Families for TNS1 Gene

HGNC:
  • DUSPQ :Protein tyrosine phosphatases / Class I Cys-based PTPs : PTENs
  • SH2D :SH2 domain containing

Suggested Antigen Peptide Sequences for TNS1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HBL0

UniProtKB/Swiss-Prot:

TENS1_HUMAN :
  • Q9HBL0
Domain:
  • Contains 1 C2 tensin-type domain.
  • Contains 1 phosphatase tensin-type domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with TNS1: view

Function for TNS1 Gene

Molecular function for TNS1 Gene

UniProtKB/Swiss-Prot Function: Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.

Gene Ontology (GO) - Molecular Function for TNS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 17190795
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with TNS1: view
genes like me logo Genes that share phenotypes with TNS1: view

Animal Models for TNS1 Gene

MGI Knock Outs for TNS1:

Animal Model Products

CRISPR Products

miRNA for TNS1 Gene

miRTarBase miRNAs that target TNS1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNS1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TNS1 Gene

Localization for TNS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNS1 Gene

Cell surface. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Localized at cell periphery preferentially to fibrillar adhesions than focal adhesions. Translocates from the cell edge to cell center in an ITGB1BP1-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNS1 Gene COMPARTMENTS Subcellular localization image for TNS1 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2
plasma membrane 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TNS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005925 focal adhesion IDA 11023826
GO:0009986 cell surface IEA --
GO:0030055 cell-substrate junction --
genes like me logo Genes that share ontologies with TNS1: view

Pathways for TNS1 Gene

genes like me logo Genes that share pathways with TNS1: view

Pathways by source for TNS1 Gene

1 Qiagen pathway for TNS1 Gene
1 BioSystems pathway for TNS1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TNS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007044 cell-substrate junction assembly IEA --
GO:0010761 fibroblast migration IEA --
GO:0035556 intracellular signal transduction --
genes like me logo Genes that share ontologies with TNS1: view

Transcripts for TNS1 Gene

Unigene Clusters for TNS1 Gene

Tensin 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNS1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TNS1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNS1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - - - -
SP2: - - -
SP3:
SP4: - - - - -
SP5:
SP6: - - - -
SP7: - - - -
SP8:
SP9: - - -
SP10:
SP11:
SP12:
SP13:

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for TNS1 Gene

GeneLoc Exon Structure for
TNS1
ECgene alternative splicing isoforms for
TNS1

Expression for TNS1 Gene

mRNA expression in normal human tissues for TNS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNS1 Gene

This gene is overexpressed in Artery - Tibial (5.8) and Artery - Aorta (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNS1 Gene

SOURCE GeneReport for Unigene cluster for TNS1 Gene Hs.471381

mRNA Expression by UniProt/SwissProt for TNS1 Gene

Q9HBL0-TENS1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with TNS1: view

In Situ Assay Products

Orthologs for TNS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNS1 35
  • 97.68 (n)
  • 97.46 (a)
TNS1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TNS1 35
  • 89.36 (n)
  • 93.16 (a)
TNS1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNS1 35
  • 89.48 (n)
  • 93.43 (a)
TNS1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tns1 35
  • 86.14 (n)
  • 89.8 (a)
Tns1 16
Tns1 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNS1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNS1 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tns1 35
  • 85.86 (n)
  • 89.03 (a)
chicken
(Gallus gallus)
Aves TNS1 35
  • 71.76 (n)
  • 73.52 (a)
lizard
(Anolis carolinensis)
Reptilia TNS1 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tns1 35
  • 66.94 (n)
  • 68.17 (a)
zebrafish
(Danio rerio)
Actinopterygii tns1 35
  • 62.07 (n)
  • 61.3 (a)
tns1 36
  • 53 (a)
OneToMany
TNS1 (2 of 2) 36
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta by 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-163 36
  • 26 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2758 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToMany
Species with no ortholog for TNS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TNS1 Gene

ENSEMBL:
Gene Tree for TNS1 (if available)
TreeFam:
Gene Tree for TNS1 (if available)

Paralogs for TNS1 Gene

Paralogs for TNS1 Gene

genes like me logo Genes that share paralogs with TNS1: view

Variants for TNS1 Gene

Sequence variations from dbSNP and Humsavar for TNS1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3746 -- 217,799,872(+) GACGC(A/G)TCAGT utr-variant-3-prime
rs3747 -- 217,799,910(+) GAGCA(G/T)ACACC utr-variant-3-prime
rs9579 -- 217,800,324(-) TTGGC(A/C)CCTCT utr-variant-3-prime
rs13454 -- 217,800,350(+) CCGAG(A/G)CCCCC utr-variant-3-prime
rs749386 -- 217,861,302(+) GAGAC(A/G)TGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNS1 Gene

Variant ID Type Subtype PubMed ID
nsv460102 CNV Loss 19166990
esv2495817 CNV Insertion 19546169
esv2229410 CNV Deletion 18987734
esv2664314 CNV Deletion 23128226
esv2721471 CNV Deletion 23290073
nsv470517 CNV Loss 18288195
nsv460103 CNV Loss 19166990
esv2670055 CNV Deletion 23128226
nsv834541 CNV Loss 17160897
nsv528835 CNV Loss 19592680
nsv875851 CNV Gain 21882294
nsv527822 CNV Loss 19592680
dgv4434n71 CNV Loss 21882294
esv1006594 CNV Deletion 20482838

Relevant External Links for TNS1 Gene

HapMap Linkage Disequilibrium report
TNS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNS1 Gene

Disorders for TNS1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for TNS1 Gene including...

Search for TNS1 Gene in MalaCards »

(3) University of Copenhagen DISEASES for TNS1 Gene

Relevant External Links for TNS1

Genetic Association Database (GAD)
TNS1
Human Genome Epidemiology (HuGE) Navigator
TNS1
genes like me logo Genes that share disorders with TNS1: view

No data available for UniProtKB/Swiss-Prot for TNS1 Gene

Publications for TNS1 Gene

  1. Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations. (PMID: 16953426) Beaty T.H. … Scott A.F. (Hum. Genet. 2006) 3 23 48
  2. Molecular characterization of human tensin. (PMID: 11023826) Chen H. … Lo S.H. (Biochem. J. 2000) 3 4
  3. Genome-wide association study identifies five loci associated with lung function. (PMID: 20010834) Repapi E. … Tobin M.D. (Nat. Genet. 2010) 3 48
  4. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PMID: 21998595) N'Diaye A. … Haiman C.A. (PLoS Genet. 2011) 3 48
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48

Products for TNS1 Gene

Sources for TNS1 Gene

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