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TNRC6C Gene

protein-coding   GIFtS: 51
GCID: GC17P076002

Trinucleotide Repeat Containing 6C

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Trinucleotide Repeat Containing 6C1 2
KIAA15823 5
Trinucleotide Repeat-Containing Gene 6C Protein2

External Ids:    HGNC: 293181   Entrez Gene: 576902   Ensembl: ENSG000000786877   OMIM: 6107415   UniProtKB: Q9HCJ03   

Export aliases for TNRC6C gene to outside databases

Previous GC identifers: GC17P073557 GC17P071424


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TNRC6C Gene:
TNRC6C (trinucleotide repeat containing 6C) is a protein-coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is TNRC6B.

UniProtKB/Swiss-Prot: TNR6C_HUMAN, Q9HCJ0
Function: Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent
translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates
with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN
deadenylase complexes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNRC6C gene promoter:
         c-Fos   AP-1   JunB   Fra-1   FosB   STAT5A   HNF-3beta   JunD   Cart-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNRC6C promoter sequence
   Search Chromatin IP Primers for TNRC6C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNRC6C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

TNRC6C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNRC6C gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P076002:  view genomic region     (about GC identifiers)

Start:
76,000,249 bp from pter      End:
76,104,916 bp from pter
Size:
104,668 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TNR6C_HUMAN, Q9HCJ0 (See protein sequence)
Recommended Name: Trinucleotide repeat-containing gene 6C protein  
Size: 1690 amino acids; 175964 Da
Subunit: Interacts with one or more of the argonaute family proteins AGO1, AGO2, AGO3 and AGO4. Interacts with
PABPC1 and EIF4G1. Interacts with CNOT1; the interaction is direct and mediates the association with the CCR4-NOT
complex. Interacts with PAN3; the interaction mediates the association with the PAN complex
Sequence caution: Sequence=BAB13408.2; Type=Erroneous initiation; Sequence=BAB71179.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for TNRC6C:
2DKL (3D)        2X04 (3D)        3KTP (3D)    
Secondary accessions: Q86UE5 Q8N3D8 Q96MU9
Alternative splicing: 2 isoforms:  Q9HCJ0-1   Q9HCJ0-2   

Explore the universe of human proteins at neXtProt for TNRC6C: NX_Q9HCJ0

Explore proteomics data for TNRC6C at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TNRC6C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001136112.1  NP_061869.2  

    ENSEMBL proteins: 
     ENSP00000467154   ENSP00000468647   ENSP00000466277   ENSP00000465707   ENSP00000336783  
     ENSP00000301624   ENSP00000440310   ENSP00000442421  
    Reactome Protein details: Q9HCJ0

    TNRC6C Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TNRC: Trinucleotide (CAG) repeat containing

    Selected InterPro protein domains (see all 7):
     IPR000449 UBA/Ts_N
     IPR015940 UBA/transl_elong_EF1B_N_euk
     IPR000504 RRM_dom
     IPR019486 Argonaute_hook_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q9HCJ0

    ProtoNet protein and cluster: Q9HCJ0

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: TNR6C_HUMAN, Q9HCJ0
    Domain: The silencing domain, also known as C-terminal effector domain (CED), can act in autonomous repression,
    including both translational inhibition and mRNA degradation
    Similarity: Belongs to the GW182 family
    Similarity: Contains 1 RRM (RNA recognition motif) domain
    Similarity: Contains 1 UBA domain


    Find genes that share domains with TNRC6C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNR6C_HUMAN, Q9HCJ0
    Function: Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent
    translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates
    with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN
    deadenylase complexes

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI19383768
         
    Find genes that share ontologies with TNRC6C           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TNRC6C:
     Increased cell death in HCC-19  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TNRC6C

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    hsa-mir-30b-5p (MIRT023444)

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    hsa-miR-124* hsa-miR-411* hsa-miR-26a-2* hsa-miR-520f hsa-miR-106a hsa-miR-938 hsa-miR-138-2* hsa-miR-759
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    Find genes that share ontologies with TNRC6C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNRC6C About   (see all 13)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82
    2PI-3K cascade
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    GAB1 signalosome0.93
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    PI-3K cascade0.88
    Signaling by ERBB40.66
    3Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    4beta-catenin independent WNT signaling
    beta-catenin independent WNT signaling0.79
    Ca2+ pathway0.43
    Signaling by Wnt0.79
    5Regulatory RNA pathways
    Regulatory RNA pathways0.88
    Post-transcriptional Silencing By Small RNAs0.00


    Find genes that share SuperPaths with TNRC6C           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected Reactome Pathways for TNRC6C (see all 6)
        Oxidative Stress Induced Senescence
    Pre-NOTCH Transcription and Translation
    Oncogene Induced Senescence
    Ca2+ pathway
    Post-transcriptional silencing by small RNAs


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TNRC6C
    Interactions:

        Search GeneGlobe Interaction Network for TNRC6C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for TNRC6C (Q9HCJ01, 2, 3 ENSP000003367834) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PABPC1P119401, 2, 3, ENSP000003130074EBI-6507625,EBI-81531 MINT-8092527 MINT-8091337 MINT-8092558 MINT-8092542 MINT-8092511 I2D: score=1 STRING: ENSP00000313007
    AGO2Q9UKV81, ENSP000002205924EBI-6507625,EBI-528269 STRING: ENSP00000220592
    CNOT1A5YKK61, ENSP000003209494STRING: ENSP00000320949 EBI-6507625,EBI-1222758
    CNOT2Q9NZN81, ENSP000002291954EBI-6507625,EBI-743033 STRING: ENSP00000229195
    MAPK6Q166593I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001706endoderm formation ----
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007219Notch signaling pathway TAS--
    GO:0007492endoderm development ----
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--

    Find genes that share ontologies with TNRC6C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNRC6C (TNR6C)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TNRC6C gene (2 alternative transcripts): 
    NM_001142640.1  NM_018996.3  

    Unigene Cluster for TNRC6C:

    Trinucleotide repeat containing 6C
    Hs.569831  [show with all ESTs]
    Unigene Representative Sequence: NM_001142640
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000588847 ENST00000588061 ENST00000585438 ENST00000588549 ENST00000591851
    ENST00000587990 ENST00000592251 ENST00000592566 ENST00000335749(uc002juf.2)
    ENST00000301624(uc002juc.2 uc002jud.2 uc002jue.2) ENST00000541771
    ENST00000544502
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TNRC6C (see all 175):
    hsa-miR-124* hsa-miR-411* hsa-miR-26a-2* hsa-miR-520f hsa-miR-106a hsa-miR-938 hsa-miR-138-2* hsa-miR-759
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      QuantiFast Probe-based Assays in human, mouse, rat TNRC6C

    Additional mRNA sequence: 

    AB046802.2 AK000022.1 AK056421.1 AK092762.1 AK098609.1 AL834429.1 BC039479.1 BC045631.1 

    13 DOTS entries:

    DT.100688925  DT.212209  DT.100751142  DT.95142253  DT.313263  DT.95120672  DT.95262106  DT.97840953 
    DT.411483  DT.70102036  DT.92024400  DT.91652404  DT.91984097 

    Selected AceView cDNA sequences (see all 143):

    AW005636 AI621245 BM705048 BQ270535 AB046802 CF142528 AI079837 AL834429 
    BG697692 BQ888996 BM724760 BX324371 AW291575 BM799796 AW450020 AI473204 
    BG014692 BF953623 H41583 H52758 CB118008 AA255824 BX509007 BQ772814 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TNRC6C    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
    SP1:        -                                         -                             -                 -                                             
    SP2:                                                  -                             -                 -           -                                 
    SP3:        -                                                                                                                                       
    SP4:                                                                                                                                                


    ECgene alternative splicing isoforms for TNRC6C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNRC6C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TNRC6C Expression
    About this image

    TNRC6C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNRC6C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.569831
        Custom PCR Arrays for TNRC6C
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNRC6C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TNRC6C gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnrc6c1 , 5 trinucleotide repeat containing 6C1, 5 90.11(n)1
    91.26(a)1
      11 (82.96 cM)5
    2173511  NM_198022.21  NP_932139.21 
     1176545735 
    chicken
    (Gallus gallus)
    Aves TNRC6C1 trinucleotide repeat containing 6C 86.95(n)
    89.39(a)
      417348  XM_004946099.1  XP_004946156.1 
    lizard
    (Anolis carolinensis)
    Reptilia TNRC6C6
    trinucleotide repeat containing 6C
    78(a)
    1 ↔ 1
    2(110769568-110893206)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tnrc6c1 trinucleotide repeat containing 6C 78.35(n)
    77.42(a)
      100496469  XM_004918433.1  XP_004918490.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.127902 Transcribed sequences 75.01(n)    57095760 
    fruit fly
    (Drosophila melanogaster)
    Insecta gw6
    gawky
    24(a)
    1 → many
    4(669667-681234)


    ENSEMBL Gene Tree for TNRC6C (if available)
    TreeFam Gene Tree for TNRC6C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNRC6C gene
    TNRC6B2  TNRC6A2  
    2 SIMAP similar genes for TNRC6C using alignment to 5 protein entries:     TNR6C_HUMAN (see all proteins):
    TNRC6A    TNRC6B

    Find genes that share paralogs with TNRC6C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNRC6C (see all 2252)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs98963711,2
    C,F,A,H--75998370(+) TGAAGG/AGTAAC 2 -- us2k123Minor allele frequency- A:0.49NS EA NA WA CSA 2347
    rs1844574811,2
    --75998377(+) TAACAC/GATTCT 2 -- us2k10--------
    rs1181311051,2
    F--75998461(+) CATTTA/GAAGCC 2 -- us2k11Minor allele frequency- G:0.01NA 120
    rs98957981,2
    C,F,H--75998478(+) TGTGGC/TTCCCG 2 -- us2k15Minor allele frequency- T:0.03NS EA WA 516
    rs1889747331,2
    --75998570(+) TTTATA/GCTTGT 2 -- us2k10--------
    rs620785501,2
    C,F--75998773(+) GTTCGA/CGACTA 2 -- us2k18Minor allele frequency- C:0.35WA NA EA 368
    rs1123594801,2
    C,F--75998796(+) TAGCAT/CGCCAT 2 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1381689811,2
    --75999003(+) GTGATG/TAAAAT 2 -- us2k10--------
    rs1437218001,2
    C--75999112(+) AGAATA/GCGGGA 2 -- us2k10--------
    rs99009411,2
    C,F--75999116(+) TGCGGG/TATAGT 2 -- us2k12Minor allele frequency- T:0.03WA 120

    HapMap Linkage Disequilibrium report for TNRC6C (76000249 - 76104916 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for TNRC6C:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv570e199CNV Deletion23128226
    dgv3277n71CNV Loss21882294
    dgv3275n71CNV Loss21882294
    nsv2153CNV Loss18451855
    nsv908860CNV Loss21882294
    dgv3276n71CNV Loss21882294
    dgv3278n71CNV Loss21882294
    nsv833554CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNRC6C
    DNA2.0 Custom Variant and Variant Library Synthesis for TNRC6C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610741    OMIM disorders: --


    Find genes that share disorders with TNRC6C           About GenesLikeMe


    Export disorders for TNRC6C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNRC6C gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with TNRC6C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression. (PubMed id 19304925)1, 2 Zipprich J.T.... Filipowicz W. (RNA 2009)
    2. The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins. (PubMed id 19383768)1, 2 Lazzaretti D.... Izaurralde E. (RNA 2009)
    3. Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. (PubMed id 19716330)1, 2 Fabian M.R.... Sonenberg N. (Mol. Cell 2009)
    4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)1, 2 Zody M.C.... Nusbaum C. (Nature 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    8. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    9. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. (PubMed id 23400010)1 Del-Aguila J.L....Boerwinkle E. (Pharmacogenomics J. 2013)
    10. miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT. (PubMed id 21984185)2 Fabian M.R.... Sonenberg N. (Nat. Struct. Mol. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57690 HGNC: 29318 AceView: KIAA1582 Ensembl:ENSG00000078687 euGenes: HUgn57690
    ECgene: TNRC6C H-InvDB: TNRC6C

    (According to HUGE)
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    HUGE: KIAA1582

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TNRC6C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TNRC6C gene:
    Search GeneIP for patents involving TNRC6C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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