Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNRC6C Gene

protein-coding   GIFtS: 50
GCID: GC17P076002

Trinucleotide Repeat Containing 6C

  Search for TNRC6C
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Trinucleotide Repeat Containing 6C1 2
KIAA15823 5
Trinucleotide Repeat-Containing Gene 6C Protein2

External Ids:    HGNC: 293181   Entrez Gene: 576902   Ensembl: ENSG000000786877   OMIM: 6107415   UniProtKB: Q9HCJ03   

Export aliases for TNRC6C gene to outside databases

Previous GC identifers: GC17P073557 GC17P071424


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TNRC6C Gene: 
TNRC6C (trinucleotide repeat containing 6C) is a protein-coding gene. Among its related super-pathways are Signaling by FGFR and Constitutive PI3K/AKT Signaling in Cancer. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is TNRC6B.

UniProtKB/Swiss-Prot: TNR6C_HUMAN, Q9HCJ0
Function: Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent
translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates
with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN
deadenylase complexes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNRC6C gene promoter:
         c-Fos   AP-1   JunB   Fra-1   FosB   STAT5A   HNF-3beta   JunD   Cart-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNRC6C promoter sequence
   Search SABiosciences Chromatin IP Primers for TNRC6C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNRC6C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

TNRC6C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNRC6C gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P076002:  view genomic region     (about GC identifiers)

Start:
76,000,249 bp from pter      End:
76,104,916 bp from pter
Size:
104,668 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TNR6C_HUMAN, Q9HCJ0 (See protein sequence)
Recommended Name: Trinucleotide repeat-containing gene 6C protein  
Size: 1690 amino acids; 175964 Da
Subunit: Interacts with one or more of the argonaute family proteins AGO1, AGO2, AGO3 and AGO4. Interacts with
PABPC1 and EIF4G1. Interacts with CNOT1; the interaction is direct and mediates the association with the CCR4-NOT
complex. Interacts with PAN3; the interaction mediates the association with the PAN complex
Sequence caution: Sequence=BAB13408.2; Type=Erroneous initiation; Sequence=BAB71179.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for TNRC6C:
2DKL (3D)        2X04 (3D)        3KTP (3D)    
Secondary accessions: Q86UE5 Q8N3D8 Q96MU9
Alternative splicing: 2 isoforms:  Q9HCJ0-1   Q9HCJ0-2   

Explore the universe of human proteins at neXtProt for TNRC6C: NX_Q9HCJ0

Explore proteomics data for TNRC6C at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HCJ0

  • TNRC6C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TNRC6C Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001136112.1  NP_061869.2  

    ENSEMBL proteins: 
     ENSP00000467154   ENSP00000468647   ENSP00000466277   ENSP00000465707   ENSP00000336783  
     ENSP00000301624   ENSP00000440310   ENSP00000442421  
    Reactome Protein details: Q9HCJ0
    Human Recombinant Protein Products for TNRC6C: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TNRC6C
    GenScript Custom Purified and Recombinant Proteins Services for TNRC6C
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TNRC6C 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    TNRC6C for ontologies           About GeneDecksing



    TNRC6C Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TNRC6C
    GenScript Custom Superior Antibodies Services for TNRC6C
    Novus Biologicals TNRC6C Antibodies
    Abcam antibodies for TNRC6C
    Cloud-Clone Corp. Antibodies for TNRC6C 
    Search ThermoFisher Antibodies for TNRC6C
    Search LSBio for Antibodies for TNRC6C 

    Assay Products for TNRC6C: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TNRC6C
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TNRC6C
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TNRC6C 
    Cloud-Clone Corp. CLIAs for TNRC6C


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TNRC: Trinucleotide (CAG) repeat containing

    5/8 InterPro protein domains (see all 8):
     IPR000449 UBA/transl_elong_EF1B_N
     IPR026804 GW182_fam
     IPR015940 UBA/transl_elong_EF1B_N_euk
     IPR000504 RRM_dom
     IPR019486 Argonaute_hook_dom

    Graphical View of Domain Structure for InterPro Entry Q9HCJ0

    ProtoNet protein and cluster: Q9HCJ0

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: TNR6C_HUMAN, Q9HCJ0
    Domain: The silencing domain, also known as C-terminal effector domain (CED), can act in autonomous repression,
    including both translational inhibition and mRNA degradation
    Similarity: Belongs to the GW182 family
    Similarity: Contains 1 RRM (RNA recognition motif) domain
    Similarity: Contains 1 UBA domain


    TNRC6C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNR6C_HUMAN, Q9HCJ0
    Function: Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent
    translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates
    with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN
    deadenylase complexes

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI19383768
         
    TNRC6C for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TNRC6C:
     Increased cell death in HCC-19  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TNRC6C 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TNRC6C

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNRC6C 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TNRC6C 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNRC6C
    8/175 QIAGEN miScript miRNA Assays for microRNAs that regulate TNRC6C (see all 175):
    hsa-miR-124* hsa-miR-411* hsa-miR-26a-2* hsa-miR-520f hsa-miR-106a hsa-miR-938 hsa-miR-138-2* hsa-miR-759
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TNRC6C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNRC6C

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TNRC6C
    Sirion Biotech Customized adenovirus for overexpression of TNRC6C

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TNRC6C (see all 9)
    OriGene ORF clones in mouse, rat for TNRC6C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TNRC6C (NM_001142640)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNRC6C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNRC6C

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TNRC6C
    Search LifeMap BioReagents cell lines for TNRC6C
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNRC6C


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TNRC6C About   (see all 12)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by FGFR
    Downstream signaling of activated FGFR0.92
    Downstream signal transduction0.90
    Signaling by FGFR0.92
    Signaling by PDGF0.85
    Signaling by FGFR in disease0.91
    Signaling by EGFR0.84
    DAP12 signaling0.91
    Signaling by EGFR in Cancer0.83
    2PIP3 activates AKT signaling
    GAB1 signalosome0.93
    PI3K events in ERBB2 signaling0.88
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    PI3K/AKT Signaling in Cancer0.88
    Signaling by ERBB40.67
    3Immune System
    Immune System0.56
    Innate Immune System0.50
    Adaptive Immune System0.56
    4Signaling by the B Cell Receptor (BCR)
    Signaling by the B Cell Receptor (BCR)0.81
    Downstream Signaling Events Of B Cell Receptor (BCR)0.81
    5Fc epsilon receptor (FCERI) signaling
    Fc epsilon receptor (FCERI) signaling0.69
    Role of LAT2/NTAL/LAB on calcium mobilization0.69

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/36        Reactome Pathways for TNRC6C (see all 36)
        Signaling by EGFR in Cancer
    Downstream signal transduction
    Signal Transduction
    Regulatory RNA pathways
    Signaling by PDGF



    TNRC6C for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TNRC6C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/17 Interacting proteins for TNRC6C (Q9HCJ01, 2, 3 ENSP000003367834) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PABPC1P119401, 2, 3, ENSP000003130074EBI-6507625,EBI-81531 MINT-8092527 MINT-8091337 MINT-8092558 MINT-8092542 MINT-8092511 I2D: score=1 STRING: ENSP00000313007
    CNOT1A5YKK61, ENSP000003209494STRING: ENSP00000320949 EBI-6507625,EBI-1222758
    CNOT2Q9NZN81, ENSP000002291954EBI-6507625,EBI-743033 STRING: ENSP00000229195
    MAPK6Q166593I2D: score=2 
    CNOT6Q9ULM61EBI-6507625,EBI-2104530
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001706endoderm formation ----
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007219Notch signaling pathway TAS--
    GO:0007492endoderm development ----
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--

    TNRC6C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNRC6C (TNR6C)

    Search CenterWatch for drugs/clinical trials and news about TNRC6C / TNR6C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNRC6C gene (2 alternative transcripts): 
    NM_001142640.1  NM_018996.3  

    Unigene Cluster for TNRC6C:

    Trinucleotide repeat containing 6C
    Hs.569831  [show with all ESTs]
    Unigene Representative Sequence: NM_001142640
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000588847 ENST00000588061 ENST00000585438 ENST00000588549 ENST00000591851
    ENST00000587990 ENST00000592251 ENST00000592566 ENST00000335749(uc002juf.2)
    ENST00000301624(uc002juc.2 uc002jud.2 uc002jue.2) ENST00000541771
    ENST00000544502
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNRC6C
    8/175 QIAGEN miScript miRNA Assays for microRNAs that regulate TNRC6C (see all 175):
    hsa-miR-124* hsa-miR-411* hsa-miR-26a-2* hsa-miR-520f hsa-miR-106a hsa-miR-938 hsa-miR-138-2* hsa-miR-759
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TNRC6C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNRC6C
    Clone
    Products:
         
    OriGene clones in human, mouse for TNRC6C (see all 9)
    OriGene ORF clones in mouse, rat for TNRC6C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TNRC6C (NM_001142640)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNRC6C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNRC6C
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TNRC6C
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TNRC6C
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNRC6C
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNRC6C

    Additional mRNA sequence: 

    AB046802.2 AK000022.1 AK056421.1 AK092762.1 AK098609.1 AL834429.1 BC039479.1 BC045631.1 

    13 DOTS entries:

    DT.100688925  DT.212209  DT.100751142  DT.95142253  DT.313263  DT.95120672  DT.95262106  DT.97840953 
    DT.411483  DT.70102036  DT.92024400  DT.91652404  DT.91984097 

    24/143 AceView cDNA sequences (see all 143):

    CB118008 AI671877 BX324371 AA255824 NM_018996 BQ270535 H52758 BM799796 
    AB046802 BG697692 BQ772814 AK056421 AA774249 AW450020 N86020 BF953623 
    CF142528 AI621245 AL834429 AI202140 BX509007 BX280269 AW291575 BG014692 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TNRC6C    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
    SP1:        -                                         -                             -                 -                                             
    SP2:                                                  -                             -                 -           -                                 
    SP3:        -                                                                                                                                       
    SP4:                                                                                                                                                


    ECgene alternative splicing isoforms for TNRC6C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNRC6C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TNRC6C Expression
    About this image


    See TNRC6C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNRC6C

    SOURCE GeneReport for Unigene cluster: Hs.569831
        SABiosciences Custom PCR Arrays for TNRC6C
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TNRC6C
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TNRC6C
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNRC6C
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNRC6C
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNRC6C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TNRC6C gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnrc6c1 , 5 trinucleotide repeat containing 6C1, 5 90.29(n)1
    91.44(a)1
      11 (82.96 cM)5
    2173511  NM_198022.21  NP_932139.21 
     1176545735 
    chicken
    (Gallus gallus)
    Aves TNRC6C1 trinucleotide repeat containing 6C 86.98(n)
    89.52(a)
      417348  XM_415612.3  XP_415612.3 
    lizard
    (Anolis carolinensis)
    Reptilia TNRC6C6
    trinucleotide repeat containing 6C
    77(a)
    1 ↔ 1
    2(110769568-110893206)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.127902 Transcribed sequences 75.01(n)    57095760 
    fruit fly
    (Drosophila melanogaster)
    Insecta gw6
    gawky
    19(a)
    1 → many
    4(669667-681234)


    ENSEMBL Gene Tree for TNRC6C (if available)
    TreeFam Gene Tree for TNRC6C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNRC6C gene
    TNRC6B2  TNRC6A2  
    2 SIMAP similar genes for TNRC6C using alignment to 5 protein entries:     TNR6C_HUMAN (see all proteins):
    TNRC6A    TNRC6B

    TNRC6C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2252 SNPs in TNRC6C are shown (see all 2252)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs98963711,2
    C,F,A,H--75998370(+) TGAAGG/AGTAAC 2 -- us2k123Minor allele frequency- A:0.49NS EA NA WA CSA 2347
    rs1844574811,2
    --75998377(+) TAACAC/GATTCT 2 -- us2k10--------
    rs1181311051,2
    F--75998461(+) CATTTA/GAAGCC 2 -- us2k11Minor allele frequency- G:0.01NA 120
    rs98957981,2
    C,F,H--75998478(+) TGTGGC/TTCCCG 2 -- us2k15Minor allele frequency- T:0.03NS EA WA 516
    rs1889747331,2
    --75998570(+) TTTATA/GCTTGT 2 -- us2k10--------
    rs620785501,2
    C,F--75998773(+) GTTCGA/CGACTA 2 -- us2k18Minor allele frequency- C:0.35WA NA EA 368
    rs1123594801,2
    C,F--75998796(+) TAGCAT/CGCCAT 2 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1381689811,2
    --75999003(+) GTGATG/TAAAAT 2 -- us2k10--------
    rs1437218001,2
    C--75999112(+) AGAATA/GCGGGA 2 -- us2k10--------
    rs99009411,2
    C,F--75999116(+) TGCGGG/TATAGT 2 -- us2k12Minor allele frequency- T:0.03WA 120

    HapMap Linkage Disequilibrium report for TNRC6C (76000249 - 76104916 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for TNRC6C:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv570e199CNV Deletion23128226
    dgv3277n71CNV Loss21882294
    dgv3275n71CNV Loss21882294
    nsv2153CNV Loss18451855
    nsv908860CNV Loss21882294
    dgv3276n71CNV Loss21882294
    dgv3278n71CNV Loss21882294
    nsv833554CNV Gain+Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TNRC6C
    DNA2.0 Custom Variant and Variant Library Synthesis for TNRC6C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TNRC6C for disorders           About MalaCards
    OMIM gene information: 610741    OMIM disorders: --


    TNRC6C for disorders           About GeneDecksing


    Export disorders for TNRC6C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNRC6C gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with TNRC6C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression. (PubMed id 19304925)1, 2 Zipprich J.T.... Filipowicz W. (2009)
    2. The C-terminal domains of human TNRC6A, TNRC6B, and T NRC6C silence bound transcripts independently of Argonaute proteins. (PubMed id 19383768)1, 2 Lazzaretti D....Izaurralde E. (2009)
    3. Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. (PubMed id 19716330)1, 2 Fabian M.R....Sonenberg N. (2009)
    4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)1, 2 Zody M.C.... Nusbaum C. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    8. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (2000)
    9. Genome-wide association analyses suggest NELL1 influen ces adverse metabolic response to HCTZ in African Americans. (PubMed id 23400010)1 Del-Aguila J.L....Boerwinkle E. (2013)
    10. miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT. (PubMed id 21984185)2 Fabian M.R....Sonenberg N. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57690 HGNC: 29318 AceView: KIAA1582 Ensembl:ENSG00000078687 euGenes: HUgn57690
    ECgene: TNRC6C H-InvDB: TNRC6C

    (According to HUGE)
    About This Section
    HUGE: KIAA1582

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNRC6C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNRC6C gene:
    Search GeneIP for patents involving TNRC6C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TNRC6C  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TNRC6C  
     OriGene qSTAR qPCR primer pairs in human, mouse for TNRC6C   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TNRC6C   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TNRC6C   OriGene Custom Protein Services for TNRC6C  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TNRC6C
     QIAGEN SeqTarget long-range PCR primers for resequencing TNRC6C
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNRC6C
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNRC6C
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNRC6C
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNRC6C
     GenScript Custom Purified and Recombinant Proteins Services for TNRC6C GenScript cDNA clones with any tag delivered in your preferred vector for TNRC6C
     GenScript Custom Assay Services for TNRC6C GenScript Custom Superior Antibodies Services for TNRC6C
     GenScript Custom overexpressing Cell Line Services for TNRC6C CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TNRC6C promoter
     Search Chromatin IP Primers for TNRC6C
     RT2 qPCR Primer Assay in human, mouse, rat TNRC6C
     Search GNC Networks for TNRC6C
     SABiosciences Custom PCR Arrays for TNRC6C
     Search Tocris compounds for TNRC6C (TNR6C)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TNRC6C antibodies
     Antibodies for TNRC6C
     See all of Abcam's Antibodies, Kits and Proteins for TNRC6C
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TNRC6C
     Antibodies for TNRC6C
     ELISAs for TNRC6C
     CLIAs for TNRC6C
     Search LifeMap BioReagents cell lines for TNRC6C
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNRC6C
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TNRC6C
     SwitchGear Promoter luciferase reporter plasmids for TNRC6C
     Search ThermoFisher Antibodies for TNRC6C
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNRC6C
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TNRC6C
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TNRC6C
    Customized:
     lentivirus for stable overexpression
     lentivirus expression plasmids for stable overexpression
     adenovirus for overexpression of TNRC6C
     Search LSBio for Antibodies for TNRC6C
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TNRC6C gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4