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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNRC6B Gene

protein-coding   GIFtS: 55
GCID: GC22P040440

Trinucleotide Repeat Containing 6B

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Trinucleotide Repeat Containing 6B1 2
KIAA10933 5
Trinucleotide Repeat-Containing Gene 6B Protein2

External Ids:    HGNC: 291901   Entrez Gene: 231122   Ensembl: ENSG000001003547   OMIM: 6107405   UniProtKB: Q9UPQ93   

Export aliases for TNRC6B gene to outside databases

Previous GC identifers: GC22P038877 GC22P038770 GC22P023404


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TNRC6B Gene: 
TNRC6B (trinucleotide repeat containing 6B) is a protein-coding gene. Diseases associated with TNRC6B include uterine fibroid, and prostate cancer, and among its related super-pathways are Signaling by FGFR and Constitutive PI3K/AKT Signaling in Cancer. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is TNRC6A.

UniProtKB/Swiss-Prot: TNR6B_HUMAN, Q9UPQ9
Function: Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs
(siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of
complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound
to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes

Gene Wiki entry for TNRC6B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNRC6B gene promoter:
         AhR   Pax-6   HTF   AP-4   Arnt   C/EBPalpha   AREB6   CHOP-10   S8   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNRC6B promoter sequence
   Search SABiosciences Chromatin IP Primers for TNRC6B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNRC6B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13

TNRC6B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNRC6B gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P040440:  view genomic region     (about GC identifiers)

Start:
40,440,821 bp from pter      End:
40,731,812 bp from pter
Size:
290,992 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TNR6B_HUMAN, Q9UPQ9 (See protein sequence)
Recommended Name: Trinucleotide repeat-containing gene 6B protein  
Size: 1833 amino acids; 194002 Da
Subunit: Interacts with AGO1, AGO2, AGO3 and AGO4. Interacts with CNOT1; the interaction mediates the association
with the CCR4-NOT complex. Interacts with PAN3; the interaction mediates the association with the PAN complex
Subcellular location: Cytoplasm, P-body. Note=Mammalian P-bodies are also known as GW bodies (GWBs)
Sequence caution: Sequence=BAA83045.2; Type=Erroneous initiation;
Secondary accessions: B0QY73 B0QY78 B4DGC0 Q5TH52 Q8TBX2
Alternative splicing: 3 isoforms:  Q9UPQ9-3   Q9UPQ9-1   Q9UPQ9-2   

Explore the universe of human proteins at neXtProt for TNRC6B: NX_Q9UPQ9

Explore proteomics data for TNRC6B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UPQ9

  • TNRC6B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TNRC6B Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001020014.1  NP_001155973.1  NP_055903.2  

    ENSEMBL proteins: 
     ENSP00000397491   ENSP00000384795   ENSP00000338371   ENSP00000409429   ENSP00000306759  
     ENSP00000401946  
    Reactome Protein details: Q9UPQ9
    Human Recombinant Protein Products for TNRC6B: 
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    Cloud-Clone Corp. Proteins for TNRC6B 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IEA--
    GO:0005829cytosol TAS--

    TNRC6B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TNRC: Trinucleotide (CAG) repeat containing

    4 InterPro protein domains:
     IPR026804 GW182_fam
     IPR019486 Argonaute_hook_dom
     IPR012677 Nucleotide-bd_a/b_plait
     IPR009060 UBA-like

    Graphical View of Domain Structure for InterPro Entry Q9UPQ9

    ProtoNet protein and cluster: Q9UPQ9

    UniProtKB/Swiss-Prot: TNR6B_HUMAN, Q9UPQ9
    Similarity: Belongs to the GW182 family
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    TNRC6B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNR6B_HUMAN, Q9UPQ9
    Function: Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs
    (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of
    complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound
    to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI17932509
         
    TNRC6B for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TNRC6B 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TNRC6B 
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TNRC6B About   (see all 12)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by FGFR
    Downstream signaling of activated FGFR0.92
    Downstream signal transduction0.90
    Signaling by FGFR0.92
    Signaling by PDGF0.85
    Signaling by FGFR in disease0.91
    Signaling by EGFR0.84
    DAP12 signaling0.91
    Signaling by EGFR in Cancer0.83
    2PIP3 activates AKT signaling
    GAB1 signalosome0.93
    PI3K events in ERBB2 signaling0.88
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    PI3K/AKT Signaling in Cancer0.88
    Signaling by ERBB40.67
    3Immune System
    Immune System0.56
    Innate Immune System0.50
    Adaptive Immune System0.56
    4Signaling by the B Cell Receptor (BCR)
    Signaling by the B Cell Receptor (BCR)0.81
    Downstream Signaling Events Of B Cell Receptor (BCR)0.81
    5Fc epsilon receptor (FCERI) signaling
    Fc epsilon receptor (FCERI) signaling0.69
    Role of LAT2/NTAL/LAB on calcium mobilization0.69

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/36        Reactome Pathways for TNRC6B (see all 36)
        Signaling by EGFR in Cancer
    Downstream signal transduction
    Signal Transduction
    Regulatory RNA pathways
    Signaling by PDGF



    TNRC6B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TNRC6B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/84 Interacting proteins for TNRC6B (Q9UPQ91, 2, 3 ENSP000003383714) via UniProtKB, MINT, STRING, and/or I2D (see all 84)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PABPC1P119402, 3, ENSP000003130074MINT-8091286 MINT-8091306 I2D: score=1 STRING: ENSP00000313007
    AGO3Q9H9G72, 3, ENSP000003622874MINT-6489217 I2D: score=2 STRING: ENSP00000362287
    AGO2Q9UKV82, 3, ENSP000002205924MINT-6489217 I2D: score=1 STRING: ENSP00000220592
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2870419 I2D: score=3 STRING: ENSP00000357292
    AGO1Q9UL183, ENSP000003623004I2D: score=1 STRING: ENSP00000362300
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006417regulation of translation IEA--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007219Notch signaling pathway TAS--
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--
    GO:0010467gene expression TAS--

    TNRC6B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNRC6B (TNR6B)

    Search CenterWatch for drugs/clinical trials and news about TNRC6B / TNR6B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNRC6B gene (3 alternative transcripts): 
    NM_001024843.1  NM_001162501.1  NM_015088.2  

    Unigene Cluster for TNRC6B:

    Trinucleotide repeat containing 6B
    Hs.372082  [show with all ESTs]
    Unigene Representative Sequence: NM_001162501
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000441751 ENST00000402203 ENST00000489500 ENST00000335727 ENST00000446273(uc003ayo.3)
    ENST00000497559 ENST00000467658 ENST00000301923(uc003aym.3) ENST00000454349(uc011aor.2 uc003ayn.4)

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    8/399 QIAGEN miScript miRNA Assays for microRNAs that regulate TNRC6B (see all 399):
    hsa-miR-194* hsa-miR-520f hsa-miR-605 hsa-miR-1260b hsa-miR-3916 hsa-miR-376a* hsa-miR-3116 hsa-miR-509-3-5p
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    Additional mRNA sequence: 

    AB029016.2 AK294519.1 AK296590.1 AK304087.1 AL831862.1 BC028626.2 BC046218.2 BX537577.1 
    BX537750.1 BX647630.1 CR627316.1 

    15 DOTS entries:

    DT.100749515  DT.97802412  DT.100749516  DT.100754251  DT.407430  DT.95336211  DT.40315344  DT.91860585 
    DT.205240  DT.91991081  DT.100642583  DT.100736601  DT.443721  DT.40261968  DT.99968010 

    24/121 AceView cDNA sequences (see all 121):

    T06335 BM313051 BQ189622 BU584245 CK300459 CB162866 BU624316 N70970 
    AA811649 BG032256 BE349160 AA824572 BI029440 BE796519 BQ009349 BE501815 
    CK822280 BU584656 BE670247 AA747718 AB029016 BE795031 BE677523 AL138375 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNRC6B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TNRC6B Expression
    About this image


    See TNRC6B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNRC6B

    SOURCE GeneReport for Unigene cluster: Hs.372082
        SABiosciences Custom PCR Arrays for TNRC6B
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNRC6B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TNRC6B gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnrc6b1 , 5 trinucleotide repeat containing 6b1, 5 94.31(n)1
    95.81(a)1
      15 (37.91 cM)5
    2139881  NM_144812.21  NP_659061.21 
     807113195 
    chicken
    (Gallus gallus)
    Aves TNRC6B6
    trinucleotide repeat containing 6B
    89(a)
    1 ↔ 1
    1(49977775-50105059)
    lizard
    (Anolis carolinensis)
    Reptilia TNRC6B6
    Uncharacterized protein
    73(a)
    1 ↔ 1
    5(25676793-25735991)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.164822 Xenopus laevis, Similar to trinucleotide repeat containing more 81.61(n)    BC041287.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa01f052 wufa01f05 76.58(n)   334730  CD756186.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta gw1 gawky 43.34(n)
    35.22(a)
      43808  NM_166785.1  NP_726601.1 


    ENSEMBL Gene Tree for TNRC6B (if available)
    TreeFam Gene Tree for TNRC6B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNRC6B gene
    TNRC6A2  TNRC6C2  
    2 SIMAP similar genes for TNRC6B using alignment to 4 protein entries:     TNR6B_HUMAN (see all proteins):
    TNRC6A    TNRC6C

    TNRC6B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5633 SNPs in TNRC6B are shown (see all 5633)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1475834601,2
    C--40438858(+) CAAGCA/GACCAA 1 -- us2k10--------
    rs1177727201,2
    F--40438937(+) CCATAC/TTGGAA 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1857940021,2
    --40438982(+) ACTCAC/TGTTCT 1 -- us2k10--------
    rs1896699821,2
    --40439090(+) AATACC/TTTGGC 1 -- us2k10--------
    rs60017311,2
    C,F,H--40439127(+) TGAGCA/TTTGTT 1 -- us2k117Minor allele frequency- T:0.10NS EA NA WA 1586
    rs1823352991,2
    --40439325(+) ATTTCA/GGTCGC 1 -- us2k10--------
    rs1421168631,2
    --40439397(+) ACTTCG/TATGAA 1 -- us2k10--------
    rs1470853521,2
    --40439525(+) TTATTC/TATTTC 1 -- us2k10--------
    rs1163674601,2
    F--40439570(+) GATTTC/ATCCTA 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs1869500531,2
    --40439640(+) TGCGAA/GTGGTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TNRC6B (40440821 - 40690821 bp, first 250kb of TNRC6B)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TNRC6B:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2724263CNV Deletion23290073
    esv2673765CNV Deletion23128226
    esv2664821CNV Deletion23128226
    nsv3630CNV Loss18451855
    esv27289CNV Loss19812545
    nsv191489CNV Loss16902084
    nsv829231CNV Loss20364138
    nsv834202CNV Loss17160897
    nsv834201CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610740    OMIM disorders: --

    3 diseases for TNRC6B:    About MalaCards
    uterine fibroid    prostate cancer    prostatitis


    TNRC6B for disorders           About GeneDecksing

    Genetic Association Database (GAD): TNRC6B
    Human Genome Epidemiology (HuGE) Navigator: TNRC6B (4 documents)

    Export disorders for TNRC6B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNRC6B gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with TNRC6B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide search for loci interacting with known p rostate cancer risk-associated genetic variants. (PubMed id 22219177)1, 4 Tao S....Sun J. (2012)
    2. Meta-analysis of genome-wide and replication associat ion studies on prostate cancer. (PubMed id 20690139)1, 4 Liu H....Han C. (2011)
    3. A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids. (PubMed id 21460842)1, 4 Cha P.C....Nakamura Y. (2011)
    4. Sequence variants at 22q13 are associated with prostate cancer risk. (PubMed id 19117981)1, 4 Sun J....Chang B.L. (2009)
    5. Prostate cancer risk associated loci in African Ameri cans. (PubMed id 19549807)1, 4 Xu J....Isaacs W.B. (2009)
    6. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. (PubMed id 19167051)1, 2 Weinmann L.... Meister G. (2009)
    7. A genome-wide association study of northwestern Europ eans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation. (PubMed id 19570815)1, 4 Estrada K....Kayser M. (2009)
    8. The C-terminal domains of human TNRC6A, TNRC6B, and T NRC6C silence bound transcripts independently of Argonaute proteins. (PubMed id 19383768)1, 2 Lazzaretti D....Izaurralde E. (2009)
    9. Identification of novel argonaute-associated proteins. (PubMed id 16289642)1, 2 Meister G....Tuschl T. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23112 HGNC: 29190 AceView: KIAA1093 Ensembl:ENSG00000100354 euGenes: HUgn23112
    ECgene: TNRC6B H-InvDB: TNRC6B

    (According to HUGE)
    About This Section
    HUGE: KIAA1093

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNRC6B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNRC6B gene:
    Search GeneIP for patents involving TNRC6B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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