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Aliases for TNRC6B Gene

Aliases for TNRC6B Gene

  • Trinucleotide Repeat Containing 6B 2 3 5
  • KIAA1093 4

External Ids for TNRC6B Gene

Previous GeneCards Identifiers for TNRC6B Gene

  • GC22P038877
  • GC22P038770
  • GC22P040440
  • GC22P023404

Summaries for TNRC6B Gene

GeneCards Summary for TNRC6B Gene

TNRC6B (Trinucleotide Repeat Containing 6B) is a Protein Coding gene. Diseases associated with TNRC6B include uterine fibroid. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include poly(A) RNA binding and nucleotide binding. An important paralog of this gene is TNRC6C.

UniProtKB/Swiss-Prot for TNRC6B Gene

  • Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.

Gene Wiki entry for TNRC6B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNRC6B Gene

Genomics for TNRC6B Gene

Regulatory Elements for TNRC6B Gene

Promoters for TNRC6B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TNRC6B on UCSC Golden Path with GeneCards custom track

Genomic Location for TNRC6B Gene

Chromosome:
22
Start:
40,044,817 bp from pter
End:
40,335,808 bp from pter
Size:
290,992 bases
Orientation:
Plus strand

Genomic View for TNRC6B Gene

Genes around TNRC6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNRC6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNRC6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNRC6B Gene

Proteins for TNRC6B Gene

  • Protein details for TNRC6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPQ9-TNR6B_HUMAN
    Recommended name:
    Trinucleotide repeat-containing gene 6B protein
    Protein Accession:
    Q9UPQ9
    Secondary Accessions:
    • B0QY73
    • B0QY78
    • B4DGC0
    • Q5TH52
    • Q8TBX2

    Protein attributes for TNRC6B Gene

    Size:
    1833 amino acids
    Molecular mass:
    194002 Da
    Quaternary structure:
    • Interacts with AGO1, AGO2, AGO3 and AGO4. Interacts with CNOT1; the interaction mediates the association with the CCR4-NOT complex. Interacts with PAN3; the interaction mediates the association with the PAN complex.
    SequenceCaution:
    • Sequence=BAA83045.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TNRC6B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNRC6B Gene

Proteomics data for TNRC6B Gene at MOPED

Post-translational modifications for TNRC6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TNRC6B Gene

Antibody Products

No data available for DME Specific Peptides for TNRC6B Gene

Domains & Families for TNRC6B Gene

Gene Families for TNRC6B Gene

Protein Domains for TNRC6B Gene

Graphical View of Domain Structure for InterPro Entry

Q9UPQ9

UniProtKB/Swiss-Prot:

TNR6B_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
  • Belongs to the GW182 family.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the GW182 family.
genes like me logo Genes that share domains with TNRC6B: view

Function for TNRC6B Gene

Molecular function for TNRC6B Gene

UniProtKB/Swiss-Prot Function:
Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.

Phenotypes for TNRC6B Gene

GenomeRNAi human phenotypes for TNRC6B:
genes like me logo Genes that share phenotypes with TNRC6B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TNRC6B

miRNA for TNRC6B Gene

miRTarBase miRNAs that target TNRC6B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNRC6B Gene

Localization for TNRC6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNRC6B Gene

Cytoplasm, P-body. Note=Mammalian P-bodies are also known as GW bodies (GWBs).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNRC6B Gene COMPARTMENTS Subcellular localization image for TNRC6B gene
Compartment Confidence
cytosol 5
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for TNRC6B Gene

Pathways & Interactions for TNRC6B Gene

genes like me logo Genes that share pathways with TNRC6B: view

Pathways by source for TNRC6B Gene

Gene Ontology (GO) - Biological Process for TNRC6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0007219 Notch signaling pathway TAS --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
GO:0010467 gene expression TAS --
GO:0031047 gene silencing by RNA IMP,TAS 19716330
genes like me logo Genes that share ontologies with TNRC6B: view

No data available for SIGNOR curated interactions for TNRC6B Gene

Drugs & Compounds for TNRC6B Gene

No Compound Related Data Available

Transcripts for TNRC6B Gene

Unigene Clusters for TNRC6B Gene

Trinucleotide repeat containing 6B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNRC6B Gene

No ASD Table

Relevant External Links for TNRC6B Gene

GeneLoc Exon Structure for
TNRC6B
ECgene alternative splicing isoforms for
TNRC6B

Expression for TNRC6B Gene

mRNA expression in normal human tissues for TNRC6B Gene

Protein differential expression in normal tissues from HIPED for TNRC6B Gene

This gene is overexpressed in Testis (15.4), Peripheral blood mononuclear cells (14.6), and Lung (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNRC6B Gene



SOURCE GeneReport for Unigene cluster for TNRC6B Gene Hs.372082

genes like me logo Genes that share expression patterns with TNRC6B: view

Protein tissue co-expression partners for TNRC6B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TNRC6B Gene

Orthologs for TNRC6B Gene

This gene was present in the common ancestor of animals.

Orthologs for TNRC6B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNRC6B 35
  • 96.15 (n)
  • 94.62 (a)
cow
(Bos Taurus)
Mammalia TNRC6B 36
  • 96 (a)
OneToOne
TNRC6B 35
  • 95.36 (n)
  • 96.34 (a)
dog
(Canis familiaris)
Mammalia TNRC6B 35
  • 96.6 (n)
  • 97.51 (a)
TNRC6B 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnrc6b 16
Tnrc6b 36
  • 94 (a)
OneToOne
Tnrc6b 35
  • 93.23 (n)
  • 94.6 (a)
oppossum
(Monodelphis domestica)
Mammalia TNRC6B 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNRC6B 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnrc6b 35
  • 93.17 (n)
  • 94.6 (a)
chicken
(Gallus gallus)
Aves TNRC6B 36
  • 90 (a)
OneToOne
TNRC6B 35
  • 88.45 (n)
  • 90.44 (a)
lizard
(Anolis carolinensis)
Reptilia TNRC6B 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16482 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tnrc6b 35
  • 73.44 (n)
  • 72.06 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-46g23.1 36
  • 39 (a)
ManyToMany
wufa01f05 35
tnrc6b 35
  • 53.89 (n)
  • 49.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta gw 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for TNRC6B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNRC6B Gene

ENSEMBL:
Gene Tree for TNRC6B (if available)
TreeFam:
Gene Tree for TNRC6B (if available)

Paralogs for TNRC6B Gene

Paralogs for TNRC6B Gene

(2) SIMAP similar genes for TNRC6B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TNRC6B: view

Variants for TNRC6B Gene

Sequence variations from dbSNP and Humsavar for TNRC6B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_051452 -
rs138686 -- 40,045,190(+) agggg(-/G)cgtga intron-variant
rs138687 -- 40,050,159(+) TGCCC(-/C)TTTGC intron-variant
rs139906 -- 40,298,166(+) atcat(A/T)aaaaa intron-variant
rs139907 -- 40,298,311(+) TTGTT(A/C)ATGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNRC6B Gene

Variant ID Type Subtype PubMed ID
nsv834201 CNV Gain 17160897
nsv191489 CNV Loss 16902084
esv2664821 CNV Deletion 23128226
nsv829231 CNV Loss 20364138
esv2724263 CNV Deletion 23290073
nsv3630 CNV Loss 18451855
nsv834202 CNV Loss 17160897
esv2673765 CNV Deletion 23128226
esv27289 CNV Loss 19812545

Variation tolerance for TNRC6B Gene

Residual Variation Intolerance Score: 3.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.67; 86.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNRC6B Gene

HapMap Linkage Disequilibrium report
TNRC6B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNRC6B Gene

Disorders for TNRC6B Gene

MalaCards: The human disease database

(1) MalaCards diseases for TNRC6B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
uterine fibroid
  • leiomyoma of corpus uteri
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TNRC6B

Genetic Association Database (GAD)
TNRC6B
Human Genome Epidemiology (HuGE) Navigator
TNRC6B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNRC6B
genes like me logo Genes that share disorders with TNRC6B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNRC6B Gene

Publications for TNRC6B Gene

  1. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S. … Sun J. (Carcinogenesis 2012) 3 48 67
  2. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  3. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  4. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. A COFRADIC protocol to study protein ubiquitination. (PMID: 24816145) Stes E. … Gevaert K. (J. Proteome Res. 2014) 3

Products for TNRC6B Gene

Sources for TNRC6B Gene

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