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TNRC6B Gene

protein-coding   GIFtS: 55
GCID: GC22P040440

Trinucleotide Repeat Containing 6B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Trinucleotide Repeat Containing 6B1 2
KIAA10933 5
Trinucleotide Repeat-Containing Gene 6B Protein2

External Ids:    HGNC: 291901   Entrez Gene: 231122   Ensembl: ENSG000001003547   OMIM: 6107405   UniProtKB: Q9UPQ93   

Export aliases for TNRC6B gene to outside databases

Previous GC identifers: GC22P038877 GC22P038770 GC22P023404


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TNRC6B Gene:
TNRC6B (trinucleotide repeat containing 6B) is a protein-coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is TNRC6A.

UniProtKB/Swiss-Prot: TNR6B_HUMAN, Q9UPQ9
Function: Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs
(siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of
complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound
to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes

Gene Wiki entry for TNRC6B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the TNRC6B gene promoter:
         AhR   Pax-6   HTF   AP-4   Arnt   C/EBPalpha   AREB6   CHOP-10   S8   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNRC6B promoter sequence
   Search Chromatin IP Primers for TNRC6B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TNRC6B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13

TNRC6B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNRC6B gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P040440:  view genomic region     (about GC identifiers)

Start:
40,440,821 bp from pter      End:
40,731,812 bp from pter
Size:
290,992 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TNR6B_HUMAN, Q9UPQ9 (See protein sequence)
Recommended Name: Trinucleotide repeat-containing gene 6B protein  
Size: 1833 amino acids; 194002 Da
Subunit: Interacts with AGO1, AGO2, AGO3 and AGO4. Interacts with CNOT1; the interaction mediates the association
with the CCR4-NOT complex. Interacts with PAN3; the interaction mediates the association with the PAN complex
Sequence caution: Sequence=BAA83045.2; Type=Erroneous initiation;
Secondary accessions: B0QY73 B0QY78 B4DGC0 Q5TH52 Q8TBX2
Alternative splicing: 3 isoforms:  Q9UPQ9-3   Q9UPQ9-1   Q9UPQ9-2   

Explore the universe of human proteins at neXtProt for TNRC6B: NX_Q9UPQ9

Explore proteomics data for TNRC6B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TNRC6B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001020014.1  NP_001155973.1  NP_055903.2  

    ENSEMBL proteins: 
     ENSP00000397491   ENSP00000384795   ENSP00000338371   ENSP00000409429   ENSP00000306759  
     ENSP00000401946  
    Reactome Protein details: Q9UPQ9

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    Cloud-Clone Corp. Proteins for TNRC6B

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TNRC: Trinucleotide (CAG) repeat containing

    3 InterPro protein domains:
     IPR026804 GW182_fam
     IPR019486 Argonaute_hook_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q9UPQ9

    ProtoNet protein and cluster: Q9UPQ9

    UniProtKB/Swiss-Prot: TNR6B_HUMAN, Q9UPQ9
    Similarity: Belongs to the GW182 family
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with TNRC6B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNR6B_HUMAN, Q9UPQ9
    Function: Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs
    (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of
    complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound
    to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI17932509
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with TNRC6B           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TNRC6B
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    hsa-mir-21-5p (MIRT030934), hsa-mir-23b-3p (MIRT046256), hsa-mir-18a-5p (MIRT031349), hsa-let-7b-5p (MIRT052116), hsa-mir-1229-3p (MIRT036287), hsa-mir-7-5p (MIRT025876), hsa-mir-183-5p (MIRT025025), hsa-mir-484 (MIRT041634), hsa-mir-103a-3p (MIRT027125), hsa-mir-31-5p (MIRT049888), hsa-mir-16-5p (MIRT031862), hsa-mir-99a-5p (MIRT048632), hsa-mir-744-5p (MIRT037407), hsa-mir-222-3p (MIRT046586), hsa-mir-320a (MIRT044431), hsa-mir-32-5p (MIRT028348), hsa-mir-125b-5p (MIRT045922), hsa-mir-19b-3p (MIRT031288)

    Block miRNA regulation of human, mouse, rat TNRC6B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TNRC6B (see all 399):
    hsa-miR-194* hsa-miR-520f hsa-miR-605 hsa-miR-1260b hsa-miR-3916 hsa-miR-376a* hsa-miR-3116 hsa-miR-509-3-5p
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNRC6B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TNR6B_HUMAN, Q9UPQ9: Cytoplasm, P-body. Note=Mammalian P-bodies are also known as GW bodies (GWBs)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    cytoskeleton1
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with TNRC6B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TNRC6B About   (see all 13)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82
    2PI-3K cascade
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    GAB1 signalosome0.93
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    PI-3K cascade0.88
    Signaling by ERBB40.66
    3Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    4beta-catenin independent WNT signaling
    beta-catenin independent WNT signaling0.79
    Ca2+ pathway0.43
    Signaling by Wnt0.79
    5Regulatory RNA pathways
    Regulatory RNA pathways0.88
    Post-transcriptional Silencing By Small RNAs0.00


    Find genes that share SuperPaths with TNRC6B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected Reactome Pathways for TNRC6B (see all 6)
        Oxidative Stress Induced Senescence
    Pre-NOTCH Transcription and Translation
    Oncogene Induced Senescence
    Ca2+ pathway
    Post-transcriptional silencing by small RNAs


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TNRC6B
    Interactions:

        Search GeneGlobe Interaction Network for TNRC6B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for TNRC6B (Q9UPQ91, 2, 3 ENSP000003383714) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PABPC1P119401, 2, 3, ENSP000003130074EBI-947158,EBI-81531 MINT-8091286 MINT-8091306 I2D: score=1 STRING: ENSP00000313007
    AGO3Q9H9G72, 3, ENSP000003622874MINT-6489217 I2D: score=2 STRING: ENSP00000362287
    AGO2Q9UKV81, 2, 3, ENSP000002205924EBI-947158,EBI-528269 MINT-6489217 I2D: score=1 STRING: ENSP00000220592
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2870419 I2D: score=3 STRING: ENSP00000357292
    AGO1Q9UL183, ENSP000003623004I2D: score=1 STRING: ENSP00000362300
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    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006417regulation of translation IEA--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007219Notch signaling pathway TAS--
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with TNRC6B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TNRC6B (TNR6B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TNRC6B gene (3 alternative transcripts): 
    NM_001024843.1  NM_001162501.1  NM_015088.2  

    Unigene Cluster for TNRC6B:

    Trinucleotide repeat containing 6B
    Hs.372082  [show with all ESTs]
    Unigene Representative Sequence: NM_001162501
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000441751 ENST00000402203 ENST00000489500 ENST00000335727 ENST00000446273(uc003ayo.3)
    ENST00000497559 ENST00000467658 ENST00000301923(uc003aym.3) ENST00000454349(uc011aor.2 uc003ayn.4)

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    hsa-miR-194* hsa-miR-520f hsa-miR-605 hsa-miR-1260b hsa-miR-3916 hsa-miR-376a* hsa-miR-3116 hsa-miR-509-3-5p
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    Additional mRNA sequence: 

    AB029016.2 AK294519.1 AK296590.1 AK304087.1 AL831862.1 BC028626.2 BC046218.2 BX537577.1 
    BX537750.1 BX647630.1 CR627316.1 

    15 DOTS entries:

    DT.100749515  DT.97802412  DT.100749516  DT.100754251  DT.407430  DT.95336211  DT.40315344  DT.91860585 
    DT.205240  DT.91991081  DT.100642583  DT.100736601  DT.443721  DT.40261968  DT.99968010 

    Selected AceView cDNA sequences (see all 121):

    AI685801 AI652916 AL138375 BE677523 BE795031 N70970 AA811649 BM674267 
    BQ189622 AA747718 BI029440 BE501815 BU584245 CK300459 BQ103849 BQ009349 
    BE349160 CK822280 AB029016 CB162866 BU624316 BE670247 BU584656 BE796519 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TNRC6B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TNRC6B Expression
    About this image

    TNRC6B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TNRC6B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.372082
        Custom PCR Arrays for TNRC6B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNRC6B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TNRC6B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnrc6b1 , 5 trinucleotide repeat containing 6b1, 5 93.23(n)1
    94.6(a)1
      15 (37.91 cM)5
    2139881  NM_144812.21  NP_659061.21 
     807113195 
    chicken
    (Gallus gallus)
    Aves TNRC6B1 trinucleotide repeat containing 6B 88.45(n)
    90.44(a)
      418010  XM_004937722.1  XP_004937779.1 
    lizard
    (Anolis carolinensis)
    Reptilia TNRC6B6
    trinucleotide repeat containing 6B
    76(a)
    1 ↔ 1
    5(25676793-25735991)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.164822 Xenopus laevis, Similar to trinucleotide repeat containing more 81.61(n)    BC041287.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa01f052 wufa01f05 76.58(n)   334730  CD756186.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta gw6
    gawky
    21(a)
    1 → many
    4(669667-681234)


    ENSEMBL Gene Tree for TNRC6B (if available)
    TreeFam Gene Tree for TNRC6B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TNRC6B gene
    TNRC6A2  TNRC6C2  
    2 SIMAP similar genes for TNRC6B using alignment to 4 protein entries:     TNR6B_HUMAN (see all proteins):
    TNRC6A    TNRC6C

    Find genes that share paralogs with TNRC6B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TNRC6B (see all 5633)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1475834601,2
    C--40438858(+) CAAGCA/GACCAA 1 -- us2k10--------
    rs1177727201,2
    F--40438937(+) CCATAC/TTGGAA 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1857940021,2
    --40438982(+) ACTCAC/TGTTCT 1 -- us2k10--------
    rs1896699821,2
    --40439090(+) AATACC/TTTGGC 1 -- us2k10--------
    rs60017311,2
    C,F,H--40439127(+) TGAGCA/TTTGTT 1 -- us2k117Minor allele frequency- T:0.10NS EA NA WA 1586
    rs1823352991,2
    --40439325(+) ATTTCA/GGTCGC 1 -- us2k10--------
    rs1421168631,2
    --40439397(+) ACTTCG/TATGAA 1 -- us2k10--------
    rs1470853521,2
    --40439525(+) TTATTC/TATTTC 1 -- us2k10--------
    rs1163674601,2
    F--40439570(+) GATTTC/ATCCTA 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs1869500531,2
    --40439640(+) TGCGAA/GTGGTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TNRC6B (40440821 - 40690821 bp, first 250kb of TNRC6B)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TNRC6B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724263CNV Deletion23290073
    esv2673765CNV Deletion23128226
    esv2664821CNV Deletion23128226
    nsv3630CNV Loss18451855
    esv27289CNV Loss19812545
    nsv191489CNV Loss16902084
    nsv829231CNV Loss20364138
    nsv834202CNV Loss17160897
    nsv834201CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TNRC6B
    DNA2.0 Custom Variant and Variant Library Synthesis for TNRC6B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 610740    OMIM disorders: --


    Find genes that share disorders with TNRC6B           About GenesLikeMe

    Genetic Association Database (GAD): TNRC6B
    Human Genome Epidemiology (HuGE) Navigator: TNRC6B (4 documents)

    Export disorders for TNRC6B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TNRC6B gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with TNRC6B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PubMed id 22219177)1, 4 Tao S....Sun J. (Carcinogenesis 2012)
    2. Meta-analysis of genome-wide and replication association studies on prostate cancer. (PubMed id 20690139)1, 4 Liu H....Han C. (Prostate 2011)
    3. A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids. (PubMed id 21460842)1, 4 Cha P.C....Nakamura Y. (Nat. Genet. 2011)
    4. Sequence variants at 22q13 are associated with prostate cancer risk. (PubMed id 19117981)1, 4 Sun J....Chang B.L. (Cancer Res. 2009)
    5. Prostate cancer risk associated loci in African Americans. (PubMed id 19549807)1, 4 Xu J....Isaacs W.B. (amp 2009)
    6. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. (PubMed id 19167051)1, 2 Weinmann L.... Meister G. (Cell 2009)
    7. A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation. (PubMed id 19570815)1, 4 Estrada K....Kayser M. (Hum. Mol. Genet. 2009)
    8. The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins. (PubMed id 19383768)1, 2 Lazzaretti D.... Izaurralde E. (RNA 2009)
    9. Identification of novel argonaute-associated proteins. (PubMed id 16289642)1, 2 Meister G.... Tuschl T. (Curr. Biol. 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23112 HGNC: 29190 AceView: KIAA1093 Ensembl:ENSG00000100354 euGenes: HUgn23112
    ECgene: TNRC6B H-InvDB: TNRC6B

    (According to HUGE)
    About This Section

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    HUGE: KIAA1093

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TNRC6B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TNRC6B gene:
    Search GeneIP for patents involving TNRC6B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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