TNRC6B Gene

Aliases
for TNRC6B gene

Previous GC identifers: GC22P038877 GC22P038770 GC22P023404

Summaries
for TNRC6B gene

Genomic Views
for TNRC6B gene

RefSeq DNA sequence:

NC_000022.10  NC_018933.1  NT_011520.12  

SwitchGear Promoter luciferase reporter plasmids (see all 2): TNRC6B promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNRC6B

TNRC6B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P040440:  view genomic region     (about GC identifiers)

Proteins
for TNRC6B gene

Explore the universe of human proteins at neXtProt for TNRC6B: NX_Q9UPQ9

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: TNRC6B OriGene Custom Protein Services for TNRC6B
	GenScript Custom Purified and Recombinant Proteins Services for TNRC6B
	Novus Biologicals TNRC6B Protein Novus Biologicals TNRC6B Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TNRC6B

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of TNRC6B
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	Browse OriGene Antibodies OriGene Custom Antibody Services for TNRC6B
	GenScript Custom Superior Antibodies Services for TNRC6B
	Novus Biologicals TNRC6B Antibodies
	Search for Antibodies for TNRC6B at Abcam
	Uscn Antibodies for TNRC6B
	Search ThermoFisher Antibodies for TNRC6B

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TNRC6B
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TNRC6B

Protein Domains /
Families
for TNRC6B gene

ProtoNet protein and cluster: Q9UPQ9

Function
for TNRC6B gene

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TNRC6B
		8/399 QIAGEN miScript miRNA Assays for microRNAs that regulate TNRC6B (see all 399):
		hsa-miR-194* hsa-miR-520f hsa-miR-605 hsa-miR-1260b hsa-miR-3916 hsa-miR-376a* hsa-miR-3116 hsa-miR-509-3-5p
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TNRC6B (see all 7) OriGene shRNA RFP: TNRC6B OriGene siRNA: TNRC6B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TNRC6B

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TNRC6B

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TNRC6B (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TNRC6B (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): TNRC6B (NM_001162501)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TNRC6B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TNRC6B

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TNRC6B
		Search LifeMap BioReagents cell lines for TNRC6B

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNRC6B

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

Pathways & Interactions
for TNRC6B gene

	Super-pathway	contained gene-specific pathways
1	Signaling by FGFR	8/12 pathways (see all 12) Signaling by FGFR 1.00 DAP12 signaling 0.83 Downstream signaling of activated FGFR 0.92 Signaling by EGFR in Cancer 0.83 Signaling by FGFR in disease 0.91 DAP12 interactions 0.76 Signaling by ERBB2 0.89 Signaling by PDGF 0.72
2	PIP3 activates AKT signaling	8/9 pathways (see all 9) PIP3 activates AKT signaling 1.00 PI3K/AKT activation 0.97 PI3K/AKT Signaling in Cancer 1.00 GAB1 signalosome 0.96 PI3K events in ERBB2 signaling 1.00 Signaling by SCF-KIT 0.72 PI3K events in ERBB4 signaling 1.00 Signaling by ERBB4 0.67
3	Immune System	Immune System 1.00 Innate Immune System 0.46 Adaptive Immune System 0.59
4	p53 positively regulates transcription of MIR34 microRNAs	p53 positively regulates transcription of MIR34 microRNAs 1.00 Pre-NOTCH Transcription and Translation 0.67 Post-transcriptional Silencing By Small RNAs 0.88
5	Signaling by the B Cell Receptor (BCR)	Signaling by the B Cell Receptor (BCR) 1.00 Downstream Signaling Events Of B Cell Receptor (BCR) 0.81

5/35        Reactome Pathways for TNRC6B

	Signaling by EGFR in Cancer
	Downstream signal transduction
	Signal Transduction
	Regulatory RNA pathways
	Signaling by PDGF

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for TNRC6B gene

Transcripts
for TNRC6B gene

Expression
for TNRC6B gene

TNRC6B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	HeartLeft Ventricle			Heart
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TNRC6B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TNRC6B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TNRC6B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNRC6B

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNRC6B

Orthologs
for TNRC6B gene

Paralogs
for TNRC6B gene

Paralogs for TNRC6B gene

TNRC6A²  TNRC6C²  

2 SIMAP similar genes for TNRC6B using alignment to 4 protein entries:     TNR6B_HUMAN (see all proteins):

TNRC6A    TNRC6C

TNRC6B for paralogs           About GeneDecksing

Genomic Variants
for TNRC6B gene

10/4586 NCBI SNPs in TNRC6B are shown (see all 4586)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1475834601,2		--	40438858(+)	CAAGCA/GACCAA	1	--	us2k1		0	--	--	--	--
rs1177727201,2	F,	--	40438937(+)	CCATAC/TTGGAA	1	--	us2k1		1		NA	120
rs1857940021,2		--	40438982(+)	ACTCAC/TGTTCT	1	--	us2k1		0	--	--	--	--
rs1896699821,2		--	40439090(+)	AATACC/TTTGGC	1	--	us2k1		0	--	--	--	--
rs60017311,2	C,F,H,	--	40439127(+)	TGAGCA/TTTGTT	1	--	us2k1		17		NS EA NA WA	1586
rs1823352991,2		--	40439325(+)	ATTTCA/GGTCGC	1	--	us2k1		0	--	--	--	--
rs1421168631,2		--	40439397(+)	ACTTCG/TATGAA	1	--	us2k1		0	--	--	--	--
rs1470853521,2		--	40439525(+)	TTATTC/TATTTC	1	--	us2k1		0	--	--	--	--
rs1163674601,2	F,	--	40439570(+)	GATTTC/ATCCTA	1	--	us2k1		1		WA	118
rs1869500531,2		--	40439640(+)	TGCGAA/GTGGTG	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for TNRC6B (40440821 - 40690821 bp, first 250kb of TNRC6B)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TNRC6B
     2 CNVs: 67893 6150

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNRC6B

DNA2.0 Custom Variant and Variant Library Synthesis for TNRC6B

Disorders / Diseases
for TNRC6B gene

Publications
for TNRC6B gene

PubMed articles for TNRC6B gene, integrated from 9 sources (see all 37): (articles sorted by number of sources associating them with TNRC6B)

Utopia: connect your pdf to the dynamic world of online information

1. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. (PubMed id 19167051)^{1, 2} Weinmann L.... Meister G. (2009)
2. Identification of novel argonaute-associated proteins. (PubMed id 16289642)^{1, 2} Meister G....Tuschl T. (2005)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (2002)
5. The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I....O'Brien K.P. (1999)
6. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)^{1, 2} Kikuno R....Ohara O. (1999)
7. A genome-wide search for loci interacting with known p rostate cancer risk-associated genetic variants. (PubMed id 22219177)¹ Tao S....Sun J. (2012)
8. Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
9. Meta-analysis of genome-wide and replication associat ion studies on prostate cancer. (PubMed id 20690139)¹ Liu H....Han C. (2011)
10. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)¹ Emanuele M.J....Elledge S.J. (2011)

External Searches for TNRC6B gene

Genome Databases showing TNRC6B gene

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Products
for TNRC6B gene