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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNRC6A Gene

protein-coding   GIFtS: 56
GCID: GC16P024741

Trinucleotide Repeat Containing 6A

(Previous name: trinucleotide repeat containing 6)
(Previous symbol: TNRC6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Trinucleotide Repeat Containing 6A1 2     GW1822 5
TNRC61 2 3     KIAA14603 5
Glycine-Tryptophan Protein Of 182 KDa2 3     Trinucleotide Repeat Containing 61
CAGH262 3     EDIE2
CAG Repeat Protein 262 3     GW12
EMSY Interactor Protein2 3     Trinucleotide Repeat-Containing Gene 6A Protein2
GW182 Autoantigen2 3     Protein GW13

External Ids:    HGNC: 119691   Entrez Gene: 273272   Ensembl: ENSG000000909057   OMIM: 6107395   UniProtKB: Q8NDV73   

Export aliases for TNRC6A gene to outside databases

Previous GC identifers: GC16P024651 GC16P022832


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNRC6A Gene:
This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in
post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein
associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies.
Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene
silencing. (provided by RefSeq, Jul 2008)

GeneCards Summary for TNRC6A Gene: 
TNRC6A (trinucleotide repeat containing 6A) is a protein-coding gene. Diseases associated with TNRC6A include sensory peripheral neuropathy, and peripheral neuropathy, and among its related super-pathways are Signaling by FGFR and Constitutive PI3K/AKT Signaling in Cancer. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is TNRC6B.

UniProtKB/Swiss-Prot: TNR6A_HUMAN, Q8NDV7
Function: Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs
(siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage
of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins
bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes

Gene Wiki entry for TNRC6A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNRC6A gene promoter:
         AML1a   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU6F1 (c2)   POU3F2   LCR-F1   NF-AT   S8   c-Myb   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTNRC6A promoter sequence
   Search SABiosciences Chromatin IP Primers for TNRC6A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNRC6A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p12.1   HGNC cytogenetic band: 16p11.2

TNRC6A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNRC6A gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P024741:  view genomic region     (about GC identifiers)

Start:
24,741,016 bp from pter      End:
24,838,953 bp from pter
Size:
97,938 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TNR6A_HUMAN, Q8NDV7 (See protein sequence)
Recommended Name: Trinucleotide repeat-containing gene 6A protein  
Size: 1962 amino acids; 210297 Da
Subunit: Interacts with AGO1, AGO2, AGO3 and AGO4. Interacts with CNOT1; the interaction is direct and mediates
the association with the CCR4-NOT complex
Subcellular location: Cytoplasm, P-body. Note=Mammalian P-bodies are also known as GW bodies (GWBs)
Miscellaneous: Antibodies against TNRC6A are found in sera from patients with Sjoegren syndrome (SS), ataxia and
sensor neuropathy diseases that developed autoantibodies against protein of the GWB structure. Autoantibodies
were mapped to the GW-rich mid-part, the non-GW-rich region and the C-terminus of the protein
Sequence caution: Sequence=BAA91899.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAD28525.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: C9JAR8 O15408 Q658L5 Q6NVB5 Q8NEZ0 Q8TBT8 Q8TCR0 Q9NV59 Q9P268
Alternative splicing: 6 isoforms:  Q8NDV7-1   Q8NDV7-2   Q8NDV7-3   Q8NDV7-4   Q8NDV7-5   Q8NDV7-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TNRC6A: NX_Q8NDV7

Explore proteomics data for TNRC6A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NDV7

  • TNRC6A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TNRC6A Protein Expression
    REFSEQ proteins: NP_055309.2  
    ENSEMBL proteins: 
     ENSP00000326900   ENSP00000379144   ENSP00000460688   ENSP00000404278   ENSP00000457273  
     ENSP00000459297   ENSP00000456394   ENSP00000403015  
    Reactome Protein details: Q8NDV7
    Human Recombinant Protein Products for TNRC6A: 
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    Cloud-Clone Corp. Proteins for TNRC6A 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IDA--
    GO:0005829cytosol TAS--
    GO:0035068micro-ribonucleoprotein complex IDA17671087

    TNRC6A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TNRC: Trinucleotide (CAG) repeat containing

    5 InterPro protein domains:
     IPR026804 GW182_fam
     IPR000504 RRM_dom
     IPR019486 Argonaute_hook_dom
     IPR012677 Nucleotide-bd_a/b_plait
     IPR009060 UBA-like

    Graphical View of Domain Structure for InterPro Entry Q8NDV7

    ProtoNet protein and cluster: Q8NDV7

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: TNR6A_HUMAN, Q8NDV7
    Similarity: Belongs to the GW182 family
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    TNRC6A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TNR6A_HUMAN, Q8NDV7
    Function: Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs
    (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage
    of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins
    bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes
    Induction: By exogenous short interfering RNA (siRNA)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI19167051
         
    TNRC6A for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tnrc6a):
     cellular  embryogenesis  hematopoietic system  integument  mortality/aging 

    TNRC6A for phenotypes           About GeneDecksing

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidTNRC6A 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TNRC6A About   (see all 12)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by FGFR
    Downstream signaling of activated FGFR0.92
    Downstream signal transduction0.90
    Signaling by FGFR0.92
    Signaling by PDGF0.85
    Signaling by FGFR in disease0.91
    Signaling by EGFR0.84
    DAP12 signaling0.91
    Signaling by EGFR in Cancer0.83
    2PIP3 activates AKT signaling
    GAB1 signalosome0.93
    PI3K events in ERBB2 signaling0.88
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    PI3K/AKT Signaling in Cancer0.88
    Signaling by ERBB40.67
    3Immune System
    Immune System0.56
    Innate Immune System0.50
    Adaptive Immune System0.56
    4Signaling by the B Cell Receptor (BCR)
    Signaling by the B Cell Receptor (BCR)0.81
    Downstream Signaling Events Of B Cell Receptor (BCR)0.81
    5Fc epsilon receptor (FCERI) signaling
    Fc epsilon receptor (FCERI) signaling0.69
    Role of LAT2/NTAL/LAB on calcium mobilization0.69

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/36        Reactome Pathways for TNRC6A (see all 36)
        Signaling by EGFR in Cancer
    Downstream signal transduction
    Signal Transduction
    Regulatory RNA pathways
    Signaling by PDGF



    TNRC6A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TNRC6A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/23 Interacting proteins for TNRC6A (Q8NDV71, 2, 3 ENSP000003791444) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF2C2Q9UKV81, 2, 3EBI-2269715,EBI-528269 MINT-8416495 MINT-8202689 I2D: score=2 
    PABPC1P119402, 3, ENSP000003130074MINT-8091323 I2D: score=1 STRING: ENSP00000313007
    EIF2C4Q9HCK51, 3EBI-2269715,EBI-2269696 I2D: score=2 
    AGO2Q9UKV81, 2, 3, ENSP000002205924EBI-2269715,EBI-528269 MINT-8416495 MINT-8202689 I2D: score=2 STRING: ENSP00000220592
    AGO4Q9HCK51, 3, ENSP000003623064EBI-2269715,EBI-2269696 I2D: score=2 STRING: ENSP00000362306
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007219Notch signaling pathway TAS--
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--
    GO:0009267cellular response to starvation IEA--
    GO:0010467gene expression TAS--

    TNRC6A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNRC6A (TNR6A)

    Search CenterWatch for drugs/clinical trials and news about TNRC6A / TNR6A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNRC6A gene: 
    NM_014494.2  

    Unigene Cluster for TNRC6A:

    Trinucleotide repeat containing 6A
    Hs.655057  [show with all ESTs]
    Unigene Representative Sequence: NM_014494
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315183 ENST00000562829 ENST00000395799(uc002dmm.3 uc010bxs.3)
    ENST00000491718(uc010vcc.1 uc002dmn.3 uc002dmo.3 uc002dmr.3)
    ENST00000450465 ENST00000568903 ENST00000567232 ENST00000561726 ENST00000568806
    ENST00000477487(uc002dmp.3) ENST00000462400(uc002dmq.3) ENST00000568750
    ENST00000563201 ENST00000569376 ENST00000569634 ENST00000569098 ENST00000464539
    ENST00000432286
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    Additional mRNA sequence: 

    AB040893.1 AJ492221.1 AK001773.1 AK025277.1 AK025696.1 AK094542.1 AK299905.1 AL713750.1 
    AL833757.1 AY035864.1 BC024324.1 BC068209.1 U23860.1 

    24/25 DOTS entries (see all 25):

    DT.95178022  DT.430273  DT.97801836  DT.100798680  DT.40295759  DT.432788  DT.70102788  DT.95233204 
    DT.65286503  DT.80100490  DT.91970371  DT.95081518  DT.95263518  DT.100720307  DT.100798681  DT.120669201 
    DT.120669229  DT.120669239  DT.70100198  DT.86844116  DT.97841498  DT.97841500  DT.116859  DT.40276330 

    24/281 AceView cDNA sequences (see all 281):

    BE042952 BE504126 AA999988 BX114192 CA446919 AI017619 BU620956 AI016937 
    BF446929 BM460693 CA842111 AA573682 NM_020847 AI699000 AI570858 N28833 
    AI359622 N52731 BQ001062 AI971197 AV656525 AA486428 CA445022 BU630033 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TNRC6A (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a ·
    SP1:                                -                 -                       -                                                                             -   
    SP2:              -                 -                 -                       -                                                                             -   
    SP3:                                -     -           -                       -                 -                                                           -   
    SP4:                                                                                                                                                        -   
    SP5:                                                                                                        -                                                   

    ExUns: 17b ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24
    SP1:                          -                                             
    SP2:                          -                                             
    SP3:                          -                                             
    SP4:                          -                             -               
    SP5:                                                                        


    ECgene alternative splicing isoforms for TNRC6A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNRC6A expression in normal human tissues (normalized intensities)      TNRC6A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTTTTTGGC
    TNRC6A Expression
    About this image


    TNRC6A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Thalamus
             ganglion/cranial   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   

    See TNRC6A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNRC6A

    SOURCE GeneReport for Unigene cluster: Hs.655057

    UniProtKB/Swiss-Prot: TNR6A_HUMAN, Q8NDV7
    Tissue specificity: Ubiquitous

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TNRC6A gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnrc6a1 , 5 trinucleotide repeat containing 6a1, 5 94.13(n)1
    94.88(a)1
      7 (67.42 cM)5
    2338331  NM_144925.31  NP_659174.31 
     1231238855 
    chicken
    (Gallus gallus)
    Aves TNRC6A1 trinucleotide repeat containing 6A 86.29(n)
    84.4(a)
      416570  XM_414871.3  XP_414871.3 
    lizard
    (Anolis carolinensis)
    Reptilia TNRC6A6
    trinucleotide repeat containing 6A
    36(a)
    1 ↔ 1
    GL343883.1(63595-106223)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.191582 Xenopus laevis transcribed sequences 85.7(n)    48060502 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.183362 Transcribed sequences 77.31(n)    BQ259801.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta gw6
    gawky
    17(a)
    1 → many
    4(669667-681234)


    ENSEMBL Gene Tree for TNRC6A (if available)
    TreeFam Gene Tree for TNRC6A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNRC6A gene
    TNRC6B2  TNRC6C2  
    2 SIMAP similar genes for TNRC6A using alignment to 7 protein entries:     TNR6A_HUMAN (see all proteins):
    TNRC6C    TNRC6B

    TNRC6A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2062 SNPs in TNRC6A are shown (see all 2062)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs340426831,2
    C,F--24739059(+) CATTAC/TGTATA 1 -- us2k13Minor allele frequency- T:0.50NA 6
    rs1465863431,2
    --24739101(+) CATAGA/TAACTT 1 -- us2k10--------
    rs787784371,2
    C,F--24739168(+) ATGAAC/ACTCAG 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs1171620051,2
    F--24739180(+) GATGAT/CAGCAG 1 -- us2k11Minor allele frequency- C:0.01EA 120
    rs803506451,2
    C,F--24739181(+) ATGATA/GGCAGG 1 -- us2k11Minor allele frequency- G:0.03NA 120
    rs1841847731,2
    C--24739183(+) GATAGC/TAGGAA 1 -- us2k10--------
    rs794996571,2
    F--24739256(+) TTTTTC/TCAAAA 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1811473361,2
    --24739346(+) GTTAAC/TGTTTT 1 -- us2k10--------
    rs1849657431,2
    C--24739404(+) CTATCA/GGAGAG 1 -- us2k10--------
    rs1412892941,2
    --24739421(+) AACCCA/CACATG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TNRC6A (24741016 - 24838953 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TNRC6A: --
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610739    OMIM disorders: --

    8 diseases for TNRC6A:    About MalaCards
    sensory peripheral neuropathy    peripheral neuropathy    neuropathy    esophageal cancer
    ataxia    esophagitis    colorectal cancer    prostatitis


    TNRC6A for disorders           About GeneDecksing


    Export disorders for TNRC6A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNRC6A gene, integrated from 9 sources (see all 64):
    (articles sorted by number of sources associating them with TNRC6A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNAs with long CAG trinucleotide repeats from human brain. (PubMed id 9225980)1, 2, 3 Margolis R.L.... Ross C.A. (1997)
    2. Clinical and serological associations of autoantibodies to GW bodies and a novel cytoplasmic autoantigen GW182. (PubMed id 14598044)1, 2, 9 Eystathioy T.... Fritzler M.J. (2003)
    3. The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies. (PubMed id 13130130)1, 2, 9 Eystathioy T....Fritzler M.J. (2003)
    4. Disruption of GW bodies impairs mammalian RNA interference. (PubMed id 16284622)1, 2, 9 Jakymiw A.... Chan E.K.L. (2005)
    5. The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing. (PubMed id 19324964)1, 2 Lian S.L....Chan E.K.L. (2009)
    6. Localization of double-stranded small interfering RNA to cytoplasmic processing bodies is Ago2 dependent and results in up-regulation of GW182 and Argonaute-2. (PubMed id 18946079)1, 2 Jagannath A. and Wood M.J.A. (2009)
    7. The C-terminal domains of human TNRC6A, TNRC6B, and T NRC6C silence bound transcripts independently of Argonaute proteins. (PubMed id 19383768)1, 2 Lazzaretti D....Izaurralde E. (2009)
    8. Identification of GW182 and its novel isoform TNGW1 as translational repressors in Ago2-mediated silencing. (PubMed id 19056672)1, 2 Li S....Chan E.K.L. (2008)
    9. Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system. (PubMed id 17671087)1, 2 Wakiyama M.... Yokoyama S. (2007)
    10. Formation of GW bodies is a consequence of microRNA genesis. (PubMed id 16906129)1, 2 Pauley K.M....Chan E.K.L. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27327 HGNC: 11969 AceView: TNRC6 Ensembl:ENSG00000090905 euGenes: HUgn27327
    ECgene: TNRC6A H-InvDB: TNRC6A

    (According to HUGE)
    About This Section
    HUGE: KIAA1460

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNRC6A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNRC6A gene:
    Search GeneIP for patents involving TNRC6A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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