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Aliases for TNRC6A Gene

Aliases for TNRC6A Gene

  • Trinucleotide Repeat Containing 6A 2 3 5
  • Glycine-Tryptophan Protein Of 182 KDa 3 4
  • EMSY Interactor Protein 3 4
  • CAG Repeat Protein 26 3 4
  • GW182 Autoantigen 3 4
  • CAGH26 3 4
  • TNRC6 3 4
  • Trinucleotide Repeat-Containing Gene 6A Protein 3
  • Trinucleotide Repeat Containing 6 2
  • CTD-2540M10.1 3
  • Protein GW1 4
  • KIAA1460 4
  • GW182 3
  • EDIE 3
  • GW1 3

External Ids for TNRC6A Gene

Previous HGNC Symbols for TNRC6A Gene

  • TNRC6

Previous GeneCards Identifiers for TNRC6A Gene

  • GC16P024741
  • GC16P022832

Summaries for TNRC6A Gene

Entrez Gene Summary for TNRC6A Gene

  • This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNRC6A Gene

TNRC6A (Trinucleotide Repeat Containing 6A) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Innate Immune System. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is TNRC6C.

UniProtKB/Swiss-Prot for TNRC6A Gene

  • Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.

Gene Wiki entry for TNRC6A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNRC6A Gene

Genomics for TNRC6A Gene

Regulatory Elements for TNRC6A Gene

Enhancers for TNRC6A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G024699 1.2 Ensembl ENCODE 12.2 +91.1 91119 3.0 CBX3 NFIB SIN3A RAD21 RFX5 YY1 GATA2 CBX5 SMARCC2 RCOR1 SLC5A11 TNRC6A LOC554206 ENSG00000261669 ENSG00000263326 SCML2P2 LINC01567 GC16M024776
GH16G024838 1.5 Ensembl ENCODE dbSUPER 5.7 +228.8 228786 1.5 ATF1 FOXA2 CREB3L1 ARNT ARID4B TCF12 GATA2 FOS NCOA1 REST TNRC6A SLC5A11 ENSG00000261669
GH16G024751 0.7 dbSUPER 12.1 +142.8 142846 2.5 TAL1 BACH1 MAFG CEBPB ATF2 FOSL1 ARID1B ZNF316 NCOR1 NFE2L1 TNRC6A SLC5A11 GC16M024776 LINC01567
GH16G024668 1.2 Ensembl ENCODE 6.5 +59.9 59870 3.7 PKNOX1 FOXA2 GLIS2 FOS DEK JUNB TSHZ1 REST TBX21 SREBF1 TNRC6A SLC5A11 LINC01567
GH16G024818 0.9 dbSUPER 8 +211.0 210957 5.0 ELF3 PKNOX1 RB1 ZFP64 KLF17 ARID4B YBX1 RAD21 ZNF121 GLIS2 SLC5A11 TNRC6A ENSG00000261669
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNRC6A on UCSC Golden Path with GeneCards custom track

Genomic Location for TNRC6A Gene

Chromosome:
16
Start:
24,610,209 bp from pter
End:
24,827,632 bp from pter
Size:
217,424 bases
Orientation:
Plus strand

Genomic View for TNRC6A Gene

Genes around TNRC6A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNRC6A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNRC6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNRC6A Gene

Proteins for TNRC6A Gene

  • Protein details for TNRC6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDV7-TNR6A_HUMAN
    Recommended name:
    Trinucleotide repeat-containing gene 6A protein
    Protein Accession:
    Q8NDV7
    Secondary Accessions:
    • C9JAR8
    • O15408
    • Q658L5
    • Q6NVB5
    • Q8NEZ0
    • Q8TBT8
    • Q8TCR0
    • Q9NV59
    • Q9P268

    Protein attributes for TNRC6A Gene

    Size:
    1962 amino acids
    Molecular mass:
    210297 Da
    Quaternary structure:
    • Interacts with AGO2 (PubMed:16284623, PubMed:16284622, PubMed:18690212, PubMed:19304925, PubMed:19324964, PubMed:19383768). Interacts with AGO1, AGO3 and AGO4 (PubMed:19324964, PubMed:19383768). Interacts with CNOT1; the interaction is direct and mediates the association with the CCR4-NOT complex (PubMed:21981923). Interacts with ZC3H12A (PubMed:26134560).
    Miscellaneous:
    • Antibodies against TNRC6A are found in sera from patients with Sjoegren syndrome (SS), ataxia and sensor neuropathy diseases that developed autoantibodies against protein of the GWB structure. Autoantibodies were mapped to the GW-rich mid-part, the non-GW-rich region and the C-terminus of the protein.
    SequenceCaution:
    • Sequence=BAA91899.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD28525.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TNRC6A Gene

neXtProt entry for TNRC6A Gene

Post-translational modifications for TNRC6A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TNRC6A Gene

Domains & Families for TNRC6A Gene

Gene Families for TNRC6A Gene

Suggested Antigen Peptide Sequences for TNRC6A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NDV7

UniProtKB/Swiss-Prot:

TNR6A_HUMAN :
  • Belongs to the GW182 family.
Family:
  • Belongs to the GW182 family.
genes like me logo Genes that share domains with TNRC6A: view

Function for TNRC6A Gene

Molecular function for TNRC6A Gene

UniProtKB/Swiss-Prot Function:
Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.
UniProtKB/Swiss-Prot Induction:
By exogenous short interfering RNA (siRNA).

Gene Ontology (GO) - Molecular Function for TNRC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA,IEA 22681889
GO:0005515 protein binding IPI 19167051
genes like me logo Genes that share ontologies with TNRC6A: view
genes like me logo Genes that share phenotypes with TNRC6A: view

Animal Model Products

miRNA for TNRC6A Gene

miRTarBase miRNAs that target TNRC6A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNRC6A Gene

Localization for TNRC6A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNRC6A Gene

Cytoplasm, P-body. Note=Mammalian P-bodies are also known as GW bodies (GWBs).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNRC6A gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 5
lysosome 1
endosome 1

Gene Ontology (GO) - Cellular Components for TNRC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IDA 20616046
GO:0005654 nucleoplasm TAS,IDA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TNRC6A: view

Pathways & Interactions for TNRC6A Gene

genes like me logo Genes that share pathways with TNRC6A: view

Gene Ontology (GO) - Biological Process for TNRC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0007223 Wnt signaling pathway, calcium modulating pathway TAS --
GO:0031047 gene silencing by RNA TAS --
GO:0035194 posttranscriptional gene silencing by RNA TAS --
GO:0035195 gene silencing by miRNA IMP 23172285
genes like me logo Genes that share ontologies with TNRC6A: view

No data available for SIGNOR curated interactions for TNRC6A Gene

Transcripts for TNRC6A Gene

Unigene Clusters for TNRC6A Gene

Trinucleotide repeat containing 6A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNRC6A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a ·
SP1: - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: -
SP5: -
SP6: -
SP7:
SP8: -
SP9:
SP10:
SP11:

ExUns: 17b ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24
SP1: -
SP2: -
SP3: -
SP4: - -
SP5:
SP6:
SP7: - - - - -
SP8:
SP9:
SP10:
SP11:

Relevant External Links for TNRC6A Gene

GeneLoc Exon Structure for
TNRC6A
ECgene alternative splicing isoforms for
TNRC6A

Expression for TNRC6A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNRC6A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TNRC6A Gene

This gene is overexpressed in Plasma (39.5) and Monocytes (24.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TNRC6A Gene



Protein tissue co-expression partners for TNRC6A Gene

NURSA nuclear receptor signaling pathways regulating expression of TNRC6A Gene:

TNRC6A

SOURCE GeneReport for Unigene cluster for TNRC6A Gene:

Hs.655057

mRNA Expression by UniProt/SwissProt for TNRC6A Gene:

Q8NDV7-TNR6A_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for TNRC6A Gene

  • Nervous system(4.7)
  • Kidney(4.3)
  • Stomach(4.3)
genes like me logo Genes that share expression patterns with TNRC6A: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNRC6A Gene

Orthologs for TNRC6A Gene

This gene was present in the common ancestor of animals.

Orthologs for TNRC6A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNRC6A 34 35
  • 96.56 (n)
dog
(Canis familiaris)
Mammalia TNRC6A 34 35
  • 95.72 (n)
cow
(Bos Taurus)
Mammalia TNRC6A 34 35
  • 95.55 (n)
mouse
(Mus musculus)
Mammalia Tnrc6a 34 16 35
  • 93.92 (n)
rat
(Rattus norvegicus)
Mammalia Tnrc6a 34
  • 93.86 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TNRC6A 35
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNRC6A 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNRC6A 34 35
  • 86.31 (n)
lizard
(Anolis carolinensis)
Reptilia TNRC6A 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnrc6a 34
  • 74.27 (n)
Str.20381 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.19158 34
zebrafish
(Danio rerio)
Actinopterygii TNRC6A 35
  • 60 (a)
OneToOne
Dr.18336 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3119 34
fruit fly
(Drosophila melanogaster)
Insecta gw 35
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToMany
Species where no ortholog for TNRC6A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNRC6A Gene

ENSEMBL:
Gene Tree for TNRC6A (if available)
TreeFam:
Gene Tree for TNRC6A (if available)

Paralogs for TNRC6A Gene

Paralogs for TNRC6A Gene

(2) SIMAP similar genes for TNRC6A Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TNRC6A: view

Variants for TNRC6A Gene

Sequence variations from dbSNP and Humsavar for TNRC6A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000004791 -- 24,807,686(+) CACTG(G/T)GTAGA intron-variant
rs1000018929 -- 24,739,260(+) ATTTA(C/T)ATTTT intron-variant
rs1000023206 -- 24,700,246(+) TCTTT(G/T)TTTTT intron-variant
rs1000027513 -- 24,725,127(+) TTCCT(A/G)ATGGA intron-variant
rs1000049551 -- 24,660,238(+) TACCC(C/T)GTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNRC6A Gene

Variant ID Type Subtype PubMed ID
esv3638258 CNV loss 21293372
nsv1113770 CNV deletion 24896259
nsv1144765 CNV deletion 24896259

Variation tolerance for TNRC6A Gene

Residual Variation Intolerance Score: 4.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.94; 95.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNRC6A Gene

Human Gene Mutation Database (HGMD)
TNRC6A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNRC6A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNRC6A Gene

Disorders for TNRC6A Gene

Relevant External Links for TNRC6A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNRC6A

No disorders were found for TNRC6A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNRC6A Gene

Publications for TNRC6A Gene

  1. Disruption of GW bodies impairs mammalian RNA interference. (PMID: 16284622) Jakymiw A. … Chan E.K.L. (Nat. Cell Biol. 2005) 3 4 22 64
  2. The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies. (PMID: 13130130) Eystathioy T. … Fritzler M.J. (RNA 2003) 3 4 22 64
  3. Clinical and serological associations of autoantibodies to GW bodies and a novel cytoplasmic autoantigen GW182. (PMID: 14598044) Eystathioy T. … Fritzler M.J. (J. Mol. Med. 2003) 3 4 22 64
  4. cDNAs with long CAG trinucleotide repeats from human brain. (PMID: 9225980) Margolis R.L. … Ross C.A. (Hum. Genet. 1997) 2 3 4 64
  5. Monocyte Chemotactic Protein-induced Protein 1 and 4 Form a Complex but Act Independently in Regulation of Interleukin-6 mRNA Degradation. (PMID: 26134560) Huang S. … Fu M. (J. Biol. Chem. 2015) 3 4 64

Products for TNRC6A Gene

Sources for TNRC6A Gene

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