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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TNRC6A Gene

protein-coding GIFtS: 54
GCID: GC16P024741

trinucleotide repeat containing 6A

(Previous name: trinucleotide repeat containing 6 )
(Previous symbol: TNRC6)

Explore 7 diseases affiliated with
TNRC6A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Trinucleotide Repeat Containing 6A¹ ²		EMSY Interactor Protein² ³
CAGH26¹ ² ³		GW182 Autoantigen² ³
TNRC6¹ ² ³		Trinucleotide Repeat Containing 6¹
GW182¹ ² ⁵		EDIE²
KIAA1460¹ ³ ⁵		GW1²
Glycine-Tryptophan Protein Of 182 KDa² ³		Trinucleotide Repeat-Containing Gene 6A Protein²
CAG Repeat Protein 26² ³		Protein GW1³

External Ids:	HGNC: 11969¹	Entrez Gene: 27327²	Ensembl: ENSG00000090905⁷	OMIM: 610739⁵	UniProtKB: Q8NDV7³

Export aliases for TNRC6A gene to outside databases

Previous GC identifers: GC16P024651 GC16P022832

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNRC6A:

This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in

post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates

with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression

of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TNR6A_HUMAN, Q8NDV7

Function: Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs).

Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of

complementary mRNAs by argonaute family proteins

Gene Wiki entry for TNRC6A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TNRC6A gene promoter:
AML1a POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU6F1 (c2) POU3F2 LCR-F1 NF-AT S8 c-Myb NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TNRC6A promoter sequence

Search SABiosciences Chromatin IP Primers for TNRC6A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNRC6A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p12.1 HGNC cytogenetic band: 16p11.2

TNRC6A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNRC6A gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P024741: view genomic region (about GC identifiers)

Start:	24,741,016 bp from pter	End:	24,838,953 bp from pter
Size:	97,938 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TNR6A_HUMAN, Q8NDV7 (See protein sequence)

Recommended Name: Trinucleotide repeat-containing gene 6A protein

Size: 1962 amino acids; 210297 Da

Subunit: Interacts with EIF2C1/AGO1, EIF2C2/AGO2, EIF2C3/AGO3 and EIF2C4/AGO4

Subcellular location: Cytoplasm, P-body. Note=Mammalian P-bodies are also known as GW bodies (GWBs)

Miscellaneous: Antibodies against TNRC6A are found in sera from patients with Sjoegren syndrome (SS), ataxia and sensor

neuropathy diseases that developed autoantibodies against protein of the GWB structure. Autoantibodies were mapped to

the GW-rich mid-part, the non-GW-rich region and the C-terminus of the protein

Sequence caution: Sequence=BAA91899.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=CAD28525.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: C9JAR8 O15408 Q658L5 Q6NVB5 Q8NEZ0 Q8TBT8 Q8TCR0 Q9NV59 Q9P268

Alternative splicing: 6 isoforms: Q8NDV7-1 Q8NDV7-2 Q8NDV7-3 Q8NDV7-4 Q8NDV7-5 Q8NDV7-6 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TNRC6A: NX_Q8NDV7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NDV7

TNRC6A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055309.2

ENSEMBL proteins:

ENSP00000326900 ENSP00000379144 ENSP00000460688 ENSP00000404278 ENSP00000457273

ENSP00000459297 ENSP00000456394 ENSP00000403015

Reactome Protein details: Q8NDV7
Human Recombinant Protein Products for TNRC6A:

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	Uscn Proteins for TNRC6A

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000932	cytoplasmic mRNA processing body	IDA	--
GO:0005829	cytosol	TAS	--
GO:0035068	micro-ribonucleoprotein complex	IDA	17671087

TNRC6A for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TNRC6A for domains About GeneDecksing

5 InterPro domains/families:

IPR026804 GW182_fam

IPR000504 RRM_dom

IPR019486 Argonaute_hook_dom

IPR012677 Nucleotide-bd_a/b_plait

IPR009060 UBA-like

Graphical View of Domain Structure for InterPro Entry Q8NDV7

ProtoNet protein and cluster: Q8NDV7

1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

UniProtKB/Swiss-Prot: TNR6A_HUMAN, Q8NDV7

Similarity: Belongs to the GW182 family

Similarity: Contains 1 RRM (RNA recognition motif) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TNR6A_HUMAN, Q8NDV7

Function: Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs).

Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of

complementary mRNAs by argonaute family proteins

Induction: By exogenous short interfering RNA (siRNA)

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003676	nucleic acid binding	--	--
GO:0003723	RNA binding	IEA	--

TNRC6A for ontologies About GeneDecksing

Phenotypes:
5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tnrc6a):

cellular

embryogenesis

hematopoietic system

integument

mortality/aging

TNRC6A for phenotypes About GeneDecksing

Animal Models:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNRC6A

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

PIP3 activates AKT signaling

8/9 pathways (see all 9)
PIP3 activates AKT signaling	1.00	PI3K/AKT activation	0.97
PI3K/AKT Signaling in Cancer	1.00	GAB1 signalosome	0.96
PI3K events in ERBB2 signaling	1.00	Signaling by SCF-KIT	0.72
PI3K events in ERBB4 signaling	1.00	Signaling by ERBB4	0.67

Immune System

	Immune System	1.00			Innate Immune System	0.46
	Adaptive Immune System	0.59

p53 positively regulates transcription of MIR34 microRNAs

	p53 positively regulates transcription of MIR34 microRNAs	1.00			Pre-NOTCH Transcription and Translation	0.67
	Post-transcriptional Silencing By Small RNAs	0.88

Signaling by the B Cell Receptor (BCR)

Signaling by the B Cell Receptor (BCR)

1.00

Downstream Signaling Events Of B Cell Receptor (BCR)

0.81

Pathway sources
See GeneCards unified pathways
Show all pathways

5/35 Reactome Pathways for TNRC6A (see all 35)

	Signaling by EGFR in Cancer
	Downstream signal transduction
	Signal Transduction
	Regulatory RNA pathways
	Signaling by PDGF

TNRC6A for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TNRC6A

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/17 Interacting proteins for TNRC6A (Q8NDV7^{2, 3} ENSP00000379144⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PABPC1	P11940²^,³, ENSP00000313007⁴	MINT-8091323 I2D: score=1 STRING: ENSP00000313007
AGO2	Q9UKV8²^,³, ENSP00000220592⁴	MINT-8202689 I2D: score=2 STRING: ENSP00000220592
TRIM71	Q2Q1W2³, ENSP00000373272⁴	I2D: score=1 STRING: ENSP00000373272
UBE2I	P63279³, ENSP00000324897⁴	I2D: score=1 STRING: ENSP00000324897
AGO4	Q9HCK5³, ENSP00000362306⁴	I2D: score=2 STRING: ENSP00000362306

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007219	Notch signaling pathway	TAS	--
GO:0009267	cellular response to starvation	IEA	--
GO:0010467	gene expression	TAS	--
GO:0035278	negative regulation of translation involved in gene silencing by miRNA	IDA	17671087

TNRC6A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TNRC6A
Search CenterWatch for drugs/clinical trials and news about TNRC6A / TNR6A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TNRC6A gene:

NM_014494.2

Unigene Cluster for TNRC6A:

Trinucleotide repeat containing 6A

Hs.655057 [show with all ESTs]

Unigene Representative Sequence: NM_014494

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000315183 ENST00000562829 ENST00000395799(uc002dmm.3 uc010bxs.3)

ENST00000491718(uc010vcc.1 uc002dmn.3 uc002dmo.3 uc002dmr.3)

ENST00000450465 ENST00000568903 ENST00000567232 ENST00000561726 ENST00000568806

ENST00000477487(uc002dmp.3) ENST00000462400(uc002dmq.3) ENST00000568750

ENST00000563201 ENST00000569376 ENST00000569634 ENST00000569098 ENST00000464539

ENST00000432286

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Additional cDNA sequence:

AB040893.1 AJ492221.1 AK001773.1 AK025277.1 AK025696.1 AK094542.1 AK299905.1 AL713750.1

AL833757.1 AY035864.1 BC024324.1 BC068209.1 U23860.1

24/25 DOTS entries (see all 25):

DT.95178022 DT.430273 DT.97801836 DT.100798680 DT.40295759 DT.432788 DT.70102788 DT.95233204

DT.65286503 DT.80100490 DT.91970371 DT.95081518 DT.95263518 DT.100720307 DT.100798681 DT.120669201

DT.120669229 DT.120669239 DT.70100198 DT.86844116 DT.97841498 DT.97841500 DT.116859 DT.40276330

24/281 AceView cDNA sequences (see all 281):

AI360954 AI146313 CB140377 AV656525 CD243059 W67163 AA486428 AI971197

N50639 CA445022 BM840419 AW958329 BM930618 AW137662 BQ932502 AI521905

AY035864 BU743266 BQ001062 N52731 AW752634 BX495114 BC024324 CA841818

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TNRC6A (see all 11) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9a	·	9b	^	10	^	11	^	12a	·	12b	^	13	^	14a	·	14b	^	15a	·	15b	^	16	^	17a	·
SP1:											-						-								-																										-
SP2:					-						-						-								-																										-
SP3:											-		-				-								-						-																				-
SP4:																																																			-
SP5:																																			-

ExUns:	17b	^	18	^	19a	·	19b	^	20a	·	20b	^	21	^	22a	·	22b	·	22c	^	23	^	24
SP1:									-
SP2:									-
SP3:									-
SP4:									-										-
SP5:

ECgene alternative splicing isoforms for TNRC6A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TNRC6A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTTTTTGGC

About this image

TNRC6A expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Somite

Thoracic Ventrolateral Dermomyotome Lip

Muscle Progenitor Cells

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TNRC6A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNRC6A

SOURCE GeneReport for Unigene cluster: Hs.655057

UniProtKB/Swiss-Prot: TNR6A_HUMAN, Q8NDV7

Tissue specificity: Ubiquitous

SABiosciences Custom PCR Arrays for TNRC6A

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TNRC6A gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tnrc6a^{1 , 5}	trinucleotide repeat containing 6a^{1, 5}	94.13(n)¹ 94.88(a)¹		7 (67.42 cM)⁵ 233833¹ NM_144925.3¹ NP_659174.3¹ 123123885⁵
chicken (Gallus gallus)	Aves	TNRC6A¹	trinucleotide repeat containing 6A	86.29(n) 84.4(a)		416570 XM_414871.3 XP_414871.3
lizard (Anolis carolinensis)	Reptilia	TNRC6A⁶	--	57(a)	1 ↔ 1	GL343883.1(70636-102082)
African clawed frog (Xenopus laevis)	Amphibia	Xl.19158²	Xenopus laevis transcribed sequences	85.7(n)		48060502
zebrafish (Danio rerio)	Actinopterygii	Dr.18336²	Transcribed sequences	77.31(n)		BQ259801.1
fruit fly (Drosophila melanogaster)	Insecta	gw⁶	gawky	17(a)	1 → many	4(669667-681234)

ENSEMBL Gene Tree for TNRC6A (if available)
TreeFam Gene Tree for TNRC6A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for TNRC6A gene

TNRC6B² TNRC6C²

2 SIMAP similar genes for TNRC6A using alignment to 7 protein entries: TNR6A_HUMAN (see all proteins):

TNRC6C TNRC6B

TNRC6A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs34042683^1,2	C,F	--	24739059(+)	`CATTAC/TGTATA`	1	--	us2k¹		3		NA	6
rs146586343^1,2		--	24739101(+)	`CATAGA/TAACTT`	1	--	us2k¹		0	--	--	--	--
rs78778437^1,2	C,F	--	24739168(+)	`ATGAAC/ACTCAG`	1	--	us2k¹		1		NA	120
rs117162005^1,2		--	24739180(+)	`GATGAT/CAGCAG`	1	--	us2k¹		1		EA	120
rs80350645^1,2	F	--	24739181(+)	`ATGATA/GGCAGG`	1	--	us2k¹		1		NA	120
rs184184773^1,2		--	24739183(+)	`GATAGC/TAGGAA`	1	--	us2k¹		0	--	--	--	--
rs79499657^1,2		--	24739256(+)	`TTTTTC/TCAAAA`	1	--	us2k¹		1		NA	2
rs181147336^1,2		--	24739346(+)	`GTTAAC/TGTTTT`	1	--	us2k¹		0	--	--	--	--
rs184965743^1,2		--	24739404(+)	`CTATCA/GGAGAG`	1	--	us2k¹		0	--	--	--	--
rs141289294^1,2		--	24739421(+)	`AACCCA/CACATG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TNRC6A (24741016 - 24838953 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TNRC6A: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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TNRC6A for disorders           About GeneDecksing

OMIM gene information: 610739    OMIM disorders: --

7 diseases for TNRC6A:    About MalaCards

sensory peripheral neuropathy peripheral neuropathy neuropathy esophageal cancer

esophagitis colorectal cancer prostatitis

Export disorders for TNRC6A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TNRC6A gene, integrated from 9 sources (see all 54):
(articles sorted by number of sources associating them with TNRC6A)

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cDNAs with long CAG trinucleotide repeats from human brain. (PubMed id 9225980)^{1, 2, 3} Margolis R.L.... Ross C.A. (1997)
Clinical and serological associations of autoantibodies to GW bodies and a novel cytoplasmic autoantigen GW182. (PubMed id 14598044)^{1, 2, 9} Eystathioy T.... Fritzler M.J. (2003)
The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies. (PubMed id 13130130)^{1, 2, 9} Eystathioy T....Fritzler M.J. (2003)
Disruption of GW bodies impairs mammalian RNA interference. (PubMed id 16284622)^{1, 2, 9} Jakymiw A.... Chan E.K.L. (2005)
The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing. (PubMed id 19324964)^{1, 2} Lian S.L....Chan E.K.L. (2009)
Localization of double-stranded small interfering RNA to cytoplasmic processing bodies is Ago2 dependent and results in up-regulation of GW182 and Argonaute-2. (PubMed id 18946079)^{1, 2} Jagannath A. and Wood M.J.A. (2009)
Identification of GW182 and its novel isoform TNGW1 as translational repressors in Ago2-mediated silencing. (PubMed id 19056672)^{1, 2} Li S....Chan E.K.L. (2008)
Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system. (PubMed id 17671087)^{1, 2} Wakiyama M.... Yokoyama S. (2007)
Formation of GW bodies is a consequence of microRNA genesis. (PubMed id 16906129)^{1, 2} Pauley K.M....Chan E.K.L. (2006)
Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies. (PubMed id 15908945)^{1, 2} Sen G.L. and Blau H.M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 27327	HGNC: 11969	AceView: TNRC6	Ensembl:ENSG00000090905	euGenes: HUgn27327
ECgene: TNRC6A	H-InvDB: TNRC6A

(According to HUGE)
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HUGE: KIAA1460

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TNRC6A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TNRC6A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TNRC6A gene:
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GeneCards and IP:
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TNRC6A Gene

trinucleotide repeat containing 6A

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TNRC6A Gene

trinucleotide repeat containing 6A

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