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Aliases for TNRC6A Gene

Aliases for TNRC6A Gene

  • Trinucleotide Repeat Containing 6A 2 3
  • Glycine-Tryptophan Protein Of 182 KDa 3 4
  • EMSY Interactor Protein 3 4
  • CAG Repeat Protein 26 3 4
  • GW182 Autoantigen 3 4
  • KIAA1460 4 6
  • CAGH26 3 4
  • TNRC6 3 4
  • GW182 3 6
  • Trinucleotide Repeat-Containing Gene 6A Protein 3
  • Trinucleotide Repeat Containing 6 2
  • Protein GW1 4
  • EDIE 3
  • GW1 3

External Ids for TNRC6A Gene

Previous HGNC Symbols for TNRC6A Gene

  • TNRC6

Previous GeneCards Identifiers for TNRC6A Gene

  • GC16P024651
  • GC16P022832

Summaries for TNRC6A Gene

Entrez Gene Summary for TNRC6A Gene

  • This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNRC6A Gene

TNRC6A (Trinucleotide Repeat Containing 6A) is a Protein Coding gene. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is TNRC6C.

UniProtKB/Swiss-Prot for TNRC6A Gene

  • Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.

Gene Wiki entry for TNRC6A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNRC6A Gene

Genomics for TNRC6A Gene

Regulatory Elements for TNRC6A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TNRC6A Gene

Start:
24,729,695 bp from pter
End:
24,827,632 bp from pter
Size:
97,938 bases
Orientation:
Plus strand

Genomic View for TNRC6A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNRC6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNRC6A Gene

Proteins for TNRC6A Gene

  • Protein details for TNRC6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDV7-TNR6A_HUMAN
    Recommended name:
    Trinucleotide repeat-containing gene 6A protein
    Protein Accession:
    Q8NDV7
    Secondary Accessions:
    • C9JAR8
    • O15408
    • Q658L5
    • Q6NVB5
    • Q8NEZ0
    • Q8TBT8
    • Q8TCR0
    • Q9NV59
    • Q9P268

    Protein attributes for TNRC6A Gene

    Size:
    1962 amino acids
    Molecular mass:
    210297 Da
    Quaternary structure:
    • Interacts with AGO1, AGO2, AGO3 and AGO4. Interacts with CNOT1; the interaction is direct and mediates the association with the CCR4-NOT complex.
    Miscellaneous:
    • Antibodies against TNRC6A are found in sera from patients with Sjoegren syndrome (SS), ataxia and sensor neuropathy diseases that developed autoantibodies against protein of the GWB structure. Autoantibodies were mapped to the GW-rich mid-part, the non-GW-rich region and the C-terminus of the protein
    SequenceCaution:
    • Sequence=BAA91899.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD28525.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TNRC6A Gene

neXtProt entry for TNRC6A Gene

Proteomics data for TNRC6A Gene at MOPED

Post-translational modifications for TNRC6A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TNRC6A Gene

No data available for DME Specific Peptides for TNRC6A Gene

Domains for TNRC6A Gene

Gene Families for TNRC6A Gene

HGNC:
  • TNRC :Trinucleotide (CAG) repeat containing

Suggested Antigen Peptide Sequences for TNRC6A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NDV7

UniProtKB/Swiss-Prot:

TNR6A_HUMAN :
  • Q8NDV7
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the GW182 family.
genes like me logo Genes that share domains with TNRC6A: view

Function for TNRC6A Gene

Molecular function for TNRC6A Gene

UniProtKB/Swiss-Prot Function: Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.
UniProtKB/Swiss-Prot Induction: By exogenous short interfering RNA (siRNA).

Gene Ontology (GO) - Molecular Function for TNRC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 19167051
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with TNRC6A: view
genes like me logo Genes that share phenotypes with TNRC6A: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNRC6A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TNRC6A Gene

Localization for TNRC6A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNRC6A Gene

Cytoplasm, P-body. Note=Mammalian P-bodies are also known as GW bodies (GWBs).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNRC6A Gene COMPARTMENTS Subcellular localization image for TNRC6A gene
Compartment Confidence
cytosol 4
golgi apparatus 3
nucleus 3

Gene Ontology (GO) - Cellular Components for TNRC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IDA 20616046
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0035068 micro-ribonucleoprotein complex IDA 17671087
genes like me logo Genes that share ontologies with TNRC6A: view

Pathways for TNRC6A Gene

genes like me logo Genes that share pathways with TNRC6A: view

Gene Ontology (GO) - Biological Process for TNRC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007219 Notch signaling pathway TAS --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
GO:0009267 cellular response to starvation IEA --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with TNRC6A: view

Transcripts for TNRC6A Gene

Unigene Clusters for TNRC6A Gene

Trinucleotide repeat containing 6A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNRC6A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TNRC6A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNRC6A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a ·
SP1: - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: -
SP5: -
SP6: -
SP7:
SP8: -
SP9:
SP10:
SP11:

ExUns: 17b ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24
SP1: -
SP2: -
SP3: -
SP4: - -
SP5:
SP6:
SP7: - - - - -
SP8:
SP9:
SP10:
SP11:

Relevant External Links for TNRC6A Gene

GeneLoc Exon Structure for
TNRC6A
ECgene alternative splicing isoforms for
TNRC6A

Expression for TNRC6A Gene

mRNA expression in normal human tissues for TNRC6A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNRC6A Gene

SOURCE GeneReport for Unigene cluster for TNRC6A Gene Hs.655057

mRNA Expression by UniProt/SwissProt for TNRC6A Gene

Q8NDV7-TNR6A_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with TNRC6A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TNRC6A Gene

Orthologs for TNRC6A Gene

This gene was present in the common ancestor of animals.

Orthologs for TNRC6A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNRC6A 35
  • 96.56 (n)
  • 96.06 (a)
TNRC6A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TNRC6A 35
  • 95.55 (n)
  • 96.3 (a)
TNRC6A 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNRC6A 35
  • 95.72 (n)
  • 96.42 (a)
TNRC6A 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnrc6a 35
  • 93.92 (n)
  • 94.46 (a)
Tnrc6a 16
Tnrc6a 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNRC6A 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNRC6A 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnrc6a 35
  • 93.86 (n)
  • 94.44 (a)
chicken
(Gallus gallus)
Aves TNRC6A 35
  • 86.31 (n)
  • 84.48 (a)
TNRC6A 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNRC6A 36
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19158 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20381 35
tnrc6a 35
  • 74.27 (n)
  • 69.84 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3119 35
zebrafish
(Danio rerio)
Actinopterygii Dr.18336 35
TNRC6A 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta gw 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for TNRC6A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNRC6A Gene

ENSEMBL:
Gene Tree for TNRC6A (if available)
TreeFam:
Gene Tree for TNRC6A (if available)

Paralogs for TNRC6A Gene

Paralogs for TNRC6A Gene

Selected SIMAP similar genes for TNRC6A Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TNRC6A: view

Variants for TNRC6A Gene

Sequence variations from dbSNP and Humsavar for TNRC6A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs10055 -- 24,824,555(-) TGTAA(A/G)CAAGA utr-variant-3-prime
rs172066 -- 24,745,128(-) AGTTA(C/T)CTGGA intron-variant
rs200526 -- 24,749,190(-) TACCT(A/G)TAGTC intron-variant
rs200527 -- 24,748,642(-) GAAAA(A/G)TGAAA intron-variant
rs200528 -- 24,747,810(-) TCCCC(C/T)TTAGT intron-variant

Relevant External Links for TNRC6A Gene

HapMap Linkage Disequilibrium report
TNRC6A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TNRC6A Gene

Disorders for TNRC6A Gene

No disorders were found for TNRC6A Gene.

No data available for UniProtKB/Swiss-Prot for TNRC6A Gene

Publications for TNRC6A Gene

  1. The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies. (PMID: 13130130) Eystathioy T. … Fritzler M.J. (RNA 2003) 3 4 23
  2. Clinical and serological associations of autoantibodies to GW bodies and a novel cytoplasmic autoantigen GW182. (PMID: 14598044) Eystathioy T. … Fritzler M.J. (J. Mol. Med. 2003) 3 4 23
  3. Disruption of GW bodies impairs mammalian RNA interference. (PMID: 16284622) Jakymiw A. … Chan E.K.L. (Nat. Cell Biol. 2005) 3 4 23
  4. cDNAs with long CAG trinucleotide repeats from human brain. (PMID: 9225980) Margolis R.L. … Ross C.A. (Hum. Genet. 1997) 2 3 4
  5. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4

Products for TNRC6A Gene

Sources for TNRC6A Gene

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