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Aliases for TNRC18 Gene

Aliases for TNRC18 Gene

  • Trinucleotide Repeat Containing 18 2 3 5
  • Long CAG Trinucleotide Repeat-Containing Gene 79 Protein 3 4
  • CAGL79 3 4
  • Trinucleotide Repeat-Containing Gene 18 Protein 3
  • KIAA1856 4
  • TNRC18A 3

External Ids for TNRC18 Gene

Previous GeneCards Identifiers for TNRC18 Gene

  • GC07M004997
  • GC07M061674
  • GC07M005097
  • GC07M005120
  • GC07U901564
  • GC07M062665

Summaries for TNRC18 Gene

GeneCards Summary for TNRC18 Gene

TNRC18 (Trinucleotide Repeat Containing 18) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is BAHCC1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNRC18 Gene

Genomics for TNRC18 Gene

Regulatory Elements for TNRC18 Gene

Enhancers for TNRC18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G005384 1.1 dbSUPER 18.2 +40.7 40675 1.2 HNRNPUL1 FOXA2 PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 TNRC18 USP42 ENSG00000188365 ENSG00000241269 ANKRD61 AP5Z1 GC07P005375
GH07G005382 1.3 ENCODE dbSUPER 13 +42.4 42426 1.9 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 SP5 NFYC MXD4 USP42 ENSG00000241269 ENSG00000188365 TNRC18 ANKRD61 AP5Z1 GC07P005375
GH07G005494 1.3 Ensembl ENCODE 11.6 -70.0 -69998 2.4 ATF1 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 ZNF143 ZNF207 KLF7 ACTB LOC100129484 TNRC18 FBXL18 MIR589 GC07M005483
GH07G005379 1.1 dbSUPER 13.5 +45.0 44975 2.6 HDGF PKNOX1 AGO1 ZFP64 ARID4B SIN3A DMAP1 FEZF1 ZNF2 ZBTB7B USP42 ANKRD61 AP5Z1 ENSG00000188365 ENSG00000241269 TNRC18 LOC100129484 RNF216P1 GC07P005375
GH07G005665 1.3 Ensembl ENCODE dbSUPER 10.8 -240.1 -240087 0.6 CTCF ESRRA SAP130 ARNT BACH1 ARID4B RAD21 ZKSCAN1 ZNF143 SMC3 ACTB FSCN1 FBXL18 MIR589 TNRC18 LOC100129484 RNF216-IT1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TNRC18 on UCSC Golden Path with GeneCards custom track

Promoters for TNRC18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000208079 814 10401 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF263 SP3 NFYC

Genomic Location for TNRC18 Gene

Chromosome:
7
Start:
5,306,790 bp from pter
End:
5,425,414 bp from pter
Size:
118,625 bases
Orientation:
Minus strand

Genomic View for TNRC18 Gene

Genes around TNRC18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNRC18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNRC18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNRC18 Gene

Proteins for TNRC18 Gene

  • Protein details for TNRC18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15417-TNC18_HUMAN
    Recommended name:
    Trinucleotide repeat-containing gene 18 protein
    Protein Accession:
    O15417
    Secondary Accessions:
    • A8MX41
    • Q96JH1
    • Q96K91

    Protein attributes for TNRC18 Gene

    Size:
    2968 amino acids
    Molecular mass:
    314519 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55047.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TNRC18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNRC18 Gene

Post-translational modifications for TNRC18 Gene

  • Ubiquitination at Lys2328
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TNRC18 Gene

Domains & Families for TNRC18 Gene

Gene Families for TNRC18 Gene

Protein Domains for TNRC18 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TNRC18 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNRC18: view

No data available for UniProtKB/Swiss-Prot for TNRC18 Gene

Function for TNRC18 Gene

Gene Ontology (GO) - Molecular Function for TNRC18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IBA --
GO:0003682 chromatin binding IBA --
genes like me logo Genes that share ontologies with TNRC18: view
genes like me logo Genes that share phenotypes with TNRC18: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNRC18 Gene

Localization for TNRC18 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNRC18 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for TNRC18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IBA --
GO:0005634 nucleus IDA --
GO:0005677 chromatin silencing complex IBA --
GO:0005739 mitochondrion IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with TNRC18: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TNRC18 Gene

Pathways & Interactions for TNRC18 Gene

SuperPathways for TNRC18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TNRC18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006342 chromatin silencing IBA --
GO:0031507 heterochromatin assembly IBA --
genes like me logo Genes that share ontologies with TNRC18: view

No data available for Pathways by source and SIGNOR curated interactions for TNRC18 Gene

Drugs & Compounds for TNRC18 Gene

No Compound Related Data Available

Transcripts for TNRC18 Gene

Unigene Clusters for TNRC18 Gene

Trinucleotide repeat containing 18:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNRC18 Gene

No ASD Table

Relevant External Links for TNRC18 Gene

GeneLoc Exon Structure for
TNRC18
ECgene alternative splicing isoforms for
TNRC18

Expression for TNRC18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNRC18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TNRC18 Gene

This gene is overexpressed in Bone (22.8), Pancreatic juice (15.6), Breast (9.2), Platelet (8.3), and Monocytes (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TNRC18 Gene



NURSA nuclear receptor signaling pathways regulating expression of TNRC18 Gene:

TNRC18

SOURCE GeneReport for Unigene cluster for TNRC18 Gene:

Hs.520638

Evidence on tissue expression from TISSUES for TNRC18 Gene

  • Nervous system(4.4)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with TNRC18: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNRC18 Gene

Orthologs for TNRC18 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNRC18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNRC18 34 35
  • 98.5 (n)
dog
(Canis familiaris)
Mammalia TNRC18 34 35
  • 87.52 (n)
cow
(Bos Taurus)
Mammalia TNRC18 34 35
  • 86.44 (n)
mouse
(Mus musculus)
Mammalia Tnrc18 34 16 35
  • 81.34 (n)
rat
(Rattus norvegicus)
Mammalia Tnrc18 34
  • 80.12 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TNRC18 35
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNRC18 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNRC18 34 35
  • 66.82 (n)
lizard
(Anolis carolinensis)
Reptilia TNRC18 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491423 34
  • 56.25 (n)
Str.19285 34
zebrafish
(Danio rerio)
Actinopterygii tnrc18 35
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta wge 35
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4643 35
  • 29 (a)
OneToMany
Species where no ortholog for TNRC18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNRC18 Gene

ENSEMBL:
Gene Tree for TNRC18 (if available)
TreeFam:
Gene Tree for TNRC18 (if available)

Paralogs for TNRC18 Gene

Paralogs for TNRC18 Gene

genes like me logo Genes that share paralogs with TNRC18: view

Variants for TNRC18 Gene

Sequence variations from dbSNP and Humsavar for TNRC18 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000024928 -- 5,368,894(+) TGTGT(C/G)TGGCC intron-variant
rs1000028499 -- 5,401,649(+) TGGGC(A/G)TTGCT intron-variant
rs1000031084 -- 5,382,094(+) ACCAT(A/C)AACCC intron-variant
rs1000047387 -- 5,413,799(+) AAGTG(C/G)TGGGA intron-variant
rs1000064178 -- 5,408,905(+) TGAGG(A/G/T)TATGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TNRC18 Gene

Variant ID Type Subtype PubMed ID
dgv11167n54 CNV loss 21841781
dgv11168n54 CNV loss 21841781
dgv3482n106 OTHER inversion 24896259
esv26599 CNV loss 19812545
esv3541093 CNV deletion 23714750
esv3541094 CNV deletion 23714750
esv3611973 CNV loss 21293372
esv8871 CNV gain 19470904
nsv1073631 CNV deletion 25765185
nsv1073632 CNV deletion 25765185
nsv1132033 CNV deletion 24896259
nsv1161487 CNV deletion 26073780
nsv436904 CNV insertion 17901297
nsv508443 CNV deletion 20534489
nsv510064 OTHER sequence alteration 20534489
nsv526194 CNV gain 19592680
nsv8034 CNV gain 18304495
nsv823996 CNV gain 20364138
nsv823997 CNV gain 20364138
nsv830889 CNV loss 17160897
nsv950801 CNV deletion 24416366
nsv966751 CNV duplication 23825009

Variation tolerance for TNRC18 Gene

Gene Damage Index Score: 16.62; 97.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNRC18 Gene

Human Gene Mutation Database (HGMD)
TNRC18
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNRC18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNRC18 Gene

Disorders for TNRC18 Gene

Relevant External Links for TNRC18

Genetic Association Database (GAD)
TNRC18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNRC18

No disorders were found for TNRC18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNRC18 Gene

Publications for TNRC18 Gene

  1. cDNAs with long CAG trinucleotide repeats from human brain. (PMID: 9225980) Margolis R.L. … Ross C.A. (Hum. Genet. 1997) 2 3 4 64
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
  3. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4 64
  4. Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131. (PMID: 26841866) Varier R.A. … Vermeulen M. (J. Biol. Chem. 2016) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for TNRC18 Gene

Sources for TNRC18 Gene

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