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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TNRC18 Gene

protein-coding GIFtS: 39
GCID: GC07M005316

trinucleotide repeat containing 18

Search for TNRC18
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Trinucleotide Repeat Containing 18¹ ²
CAGL79¹ ² ³
TNRC18A¹ ²
KIAA1856¹ ³
Long CAG Trinucleotide Repeat-Containing Gene 79 Protein² ³
Trinucleotide Repeat-Containing Gene 18 Protein²

External Ids:	HGNC: 11962¹	Entrez Gene: 84629²	Ensembl: ENSG00000182095⁷	UniProtKB: O15417³

Export aliases for TNRC18 gene to outside databases

Previous GC identifers: GC07M004997 GC07M061674 GC07M005097 GC07M005120 GC07U901564 GC07M062665

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TNRC18 gene promoter:
E2F-4 E2F-3a E2F-5 E2F-2 E2F E2F-1 CBF-A COMP1 PPAR-gamma2 CBF(2)
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for TNRC18

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNRC18

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.1 Ensembl cytogenetic band: 7p22.1 HGNC cytogenetic band: 7p22.1

TNRC18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNRC18 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M005316: view genomic region (about GC identifiers)

Start:	5,346,421 bp from pter	End:	5,465,045 bp from pter
Size:	118,625 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 5,392,776-5,509,531

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TNC18_HUMAN, O15417 (See protein sequence)

Recommended Name: Trinucleotide repeat-containing gene 18 protein

Size: 2968 amino acids; 314519 Da

Sequence caution: Sequence=BAB55047.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: A8MX41 Q96JH1 Q96K91

Alternative splicing: 3 isoforms: O15417-1 O15417-2 O15417-3 (Incomplete sequence. No experimental confirmation available. Non-canonical intron-exon splice junction)

Explore the universe of human proteins at neXtProt for TNRC18: NX_O15417

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O15417

TNRC18 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001073964.2

ENSEMBL proteins:

ENSP00000382452 ENSP00000329902 ENSP00000398809 ENSP00000395990 ENSP00000413911

ENSP00000410856 ENSP00000382364 ENSP00000395538

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TNRC18 for domains About GeneDecksing

1 InterPro domain/family:

IPR001025 BAH_dom

Graphical View of Domain Structure for InterPro Entry O15417

ProtoNet protein and cluster: O15417

UniProtKB/Swiss-Prot: TNC18_HUMAN, O15417

Similarity: Contains 1 BAH domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--

TNRC18 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for TNRC18:

Increased HPV18 LCR reporter a

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TNRC18

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNRC18

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TNRC18

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for TNRC18 (O15417² ENSP00000395538⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BECN1	Q14457², ENSP00000355231⁴	MINT-8304740 STRING: ENSP00000355231
SUMO2	ENSP00000405965⁴	STRING: ENSP00000405965
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TNRC18
Search CenterWatch for drugs/clinical trials and news about TNRC18 / TNC18

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TNRC18 gene (2 alternative transcripts):

NM_001080495.2 NM_001013722.1

Unigene Cluster for TNRC18:

Trinucleotide repeat containing 18

Hs.520638 [show with all ESTs]

Unigene Representative Sequence: NM_001080495

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000399537(uc003soi.4) ENST00000328270 ENST00000464852 ENST00000455076

ENST00000497663 ENST00000440081 ENST00000413081 ENST00000434361 ENST00000399434(uc003sok.1)

ENST00000430969(uc003soj.3 uc010ksx.1)

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		8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate TNRC18 (see all 62):
		hsa-miR-4291 hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-136 hsa-miR-4328 hsa-miR-513a-5p hsa-miR-128

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AB058759.1 AF075006.1 AK027341.1 AK057263.1 AY129022.1 BC029940.1 BC036932.1 BC068099.1

BC131808.1 BC140723.1 U80753.1

24/25 DOTS entries (see all 25):

DT.448669 DT.111505 DT.405454 DT.100748928 DT.424900 DT.121042462 DT.97798144 DT.97860843

DT.95285475 DT.100748222 DT.95248584 DT.99928805 DT.70103177 DT.95077342 DT.95219479 DT.100031653

DT.40201797 DT.40316671 DT.449527 DT.100857479 DT.121042455 DT.121042510 DT.40232367 DT.92476533

24/233 AceView cDNA sequences (see all 233):

AW136114 AI950932 AI198110 BE041754 AA974367 AB058759 AI744934 AI274581

BM665981 BE890954 BM746776 R49939 AI564053 BF941042 AL040369 CA748613

AI469086 AA400049 AA077157 AI868645 BC068099 AW630193 AA662655 BU742912

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TNRC18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGACAGGGCA

About this image

TNRC18 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Somite

Lumbar Vertebral Body

Somite

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TNRC18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TNRC18

SOURCE GeneReport for Unigene cluster: Hs.520638

SABiosciences Custom PCR Arrays for TNRC18

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TNRC18 gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TNRC18¹	trinucleotide repeat containing 18	67.71(n) 64.47(a)		416482 XM_001233345.2 XP_001233346.2
lizard (Anolis carolinensis)	Reptilia	TNRC18⁶	--	55(a)	1 ↔ 1	GL343591.1(376947-423765)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.19285²	Transcribed sequences	76.96(n)		AL846285.2
zebrafish (Danio rerio)	Actinopterygii	LOC559514¹	uncharacterized protein LOC559514	57.58(n) 53.08(a)		559514 XM_002661214.2 XP_002661260.2
fruit fly (Drosophila melanogaster)	Insecta	wge⁶	winged eye	17(a)	1 → many	3R(18536605-18546872)

ENSEMBL Gene Tree for TNRC18 (if available)
TreeFam Gene Tree for TNRC18 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TNRC18 gene

BAHCC1²

TNRC18 for paralogs About GeneDecksing

5 Pseudogenes.org Pseudogenes for TNRC18
PGOHUM00000245713 PGOHUM00000232790 PGOHUM00000232791 PGOHUM00000233274 PGOHUM00000233275

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs181911198^1,2		--	5345950(+)	`CCTCCC/TGAGTA`	1	--	int¹		0	--	--	--	--
rs185841362^1,2		--	5346052(+)	`AACTCC/TTGGCC`	1	--	int¹		0	--	--	--	--
rs148088597^1,2	C	--	5346075(+)	`CCCGCC/GTCGGC`	1	--	int¹		0	--	--	--	--
rs4720578^1,2	C,H	--	5346196(+)	`CTGACC/TTCAAG`	1	--	int¹		7		NA WA CSA	13
rs62441153^1,2		--	5346244(+)	`ACAGGC/TGTGAG`	1	--	int¹		0	--	--	--	--
rs62441154^1,2	F	--	5346298(+)	`GTCACC/TGCCCC`	1	--	int¹		2		WA NA	238
rs62441155^1,2	F	--	5346308(+)	`CTGCAC/TGCGTG`	1	--	int¹		3		WA NA EA	358
rs78220096^1,2	C	--	5346455(+)	`TTTTTA/TATGAA`	1	--	ut3¹		0	--	--	--	--
rs190251892^1,2		--	5346474(+)	`ACACAC/GAATTT`	1	--	ut3¹		0	--	--	--	--
rs182445426^1,2		--	5346509(+)	`AACATA/TAAAAA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TNRC18 (5346421 - 5465045 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for TNRC18
4 CNVs: 69786 81856 31328 94357
1 Indel: 60644

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TNRC18

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TNRC18 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with TNRC18)

Utopia: connect your pdf to the dynamic
world of online information

cDNAs with long CAG trinucleotide repeats from human brain. (PubMed id 9225980)^{1, 2, 3} Margolis R.L.... Ross C.A. (1997)
Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)^{1, 2} Denis N.J.... Figeys D. (2007)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)^{1, 2} Nagase T.... Ohara O. (2001)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)¹ Tatham M.H....Hay R.T. (2011)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)² Mayya V.... Han D.K. (2009)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84629	HGNC: 11962	AceView: KIAA1856	Ensembl:ENSG00000182095	euGenes: HUgn84629
ECgene: TNRC18	H-InvDB: TNRC18

(According to HUGE)
About This Section

HUGE: KIAA1856

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TNRC18	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TNRC18 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TNRC18 gene:
Search GeneIP for patents involving TNRC18

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	Browse OriGene Antibodies		OriGene shRNA RFP for TNRC18
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TNRC18
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	GenScript Custom Purified and Recombinant Proteins Services for TNRC18		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for TNRC18
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	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TNRC18

Sirion Biotech Customized:

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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TNRC18 gene at Home site.

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TNRC18 Gene

trinucleotide repeat containing 18

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TNRC18 Gene

trinucleotide repeat containing 18

Aliasesfor TNRC18 gene

Summariesfor TNRC18 gene

Genomic Viewsfor TNRC18 gene

Proteinsfor TNRC18 gene

Protein Domains /Familiesfor TNRC18 gene

Functionfor TNRC18 gene

Pathways & Interactionsfor TNRC18 gene

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Expression for TNRC18 gene

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External Searches for TNRC18 gene

Genome Databases showing TNRC18 gene

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for TNRC18 gene

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for TNRC18 gene

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for TNRC18 gene

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for TNRC18 gene

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Families
for TNRC18 gene

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for TNRC18 gene

Pathways & Interactions
for TNRC18 gene

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for TNRC18 gene

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for TNRC18 gene

Expression
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Orthologs
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for TNRC18 gene

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