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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TNRC18 Gene

protein-coding   GIFtS: 41
GCID: GC07M005316

Trinucleotide Repeat Containing 18

  Search for TNRC18
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Trinucleotide Repeat Containing 181 2
Long CAG Trinucleotide Repeat-Containing Gene 79 Protein2 3
CAGL792 3
TNRC18A2
Trinucleotide Repeat-Containing Gene 18 Protein2
KIAA18563

External Ids:    HGNC: 119621   Entrez Gene: 846292   Ensembl: ENSG000001820957   UniProtKB: O154173   

Export aliases for TNRC18 gene to outside databases

Previous GC identifers: GC07M004997 GC07M061674 GC07M005097 GC07M005120 GC07U901564 GC07M062665


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TNRC18 Gene: 
TNRC18 (trinucleotide repeat containing 18) is a protein-coding gene. GO annotations related to this gene include DNA binding. An important paralog of this gene is BAHCC1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TNRC18 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-2   E2F   E2F-1   CBF-A   COMP1   PPAR-gamma2   CBF(2)   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TNRC18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TNRC18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.1   Ensembl cytogenetic band:  7p22.1   HGNC cytogenetic band: 7p22.1

TNRC18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNRC18 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M005316:  view genomic region     (about GC identifiers)

Start:
5,346,421 bp from pter      End:
5,465,045 bp from pter
Size:
118,625 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 5,392,776-5,509,531     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TNC18_HUMAN, O15417 (See protein sequence)
Recommended Name: Trinucleotide repeat-containing gene 18 protein  
Size: 2968 amino acids; 314519 Da
Sequence caution: Sequence=BAB55047.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8MX41 Q96JH1 Q96K91
Alternative splicing: 3 isoforms:  O15417-1   O15417-2   O15417-3   (Incomplete sequence. No experimental confirmation available. Non-canonical intron-exon splice junction)

Explore the universe of human proteins at neXtProt for TNRC18: NX_O15417

Explore proteomics data for TNRC18 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15417

  • TNRC18 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TNRC18 Protein Expression
    REFSEQ proteins: NP_001073964.2  
    ENSEMBL proteins: 
     ENSP00000382452   ENSP00000329902   ENSP00000398809   ENSP00000395990   ENSP00000413911  
     ENSP00000410856   ENSP00000382364   ENSP00000395538  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TNRC: Trinucleotide (CAG) repeat containing

    1 InterPro protein domain:
     IPR001025 BAH_dom

    Graphical View of Domain Structure for InterPro Entry O15417

    ProtoNet protein and cluster: O15417

    UniProtKB/Swiss-Prot: TNC18_HUMAN, O15417
    Similarity: Contains 1 BAH domain


    TNRC18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
         
    TNRC18 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TNRC18:
     Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TNRC18 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TNRC18

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for TNRC18 (O154172 ENSP000003955384) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BECN1Q144572, ENSP000003552314MINT-8304740 STRING: ENSP00000355231
    SUMO2ENSP000004059654STRING: ENSP00000405965
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TNRC18 (TNC18)

    Search CenterWatch for drugs/clinical trials and news about TNRC18 / TNC18

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TNRC18 gene (2 alternative transcripts): 
    NM_001080495.2  NM_001013722.1  

    Unigene Cluster for TNRC18:

    Trinucleotide repeat containing 18
    Hs.520638  [show with all ESTs]
    Unigene Representative Sequence: NM_001080495
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399537(uc003soi.4) ENST00000328270 ENST00000464852 ENST00000455076
    ENST00000497663 ENST00000440081 ENST00000413081 ENST00000434361 ENST00000399434(uc003sok.1)
    ENST00000430969(uc003soj.3 uc010ksx.1)
    miRNA
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    8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate TNRC18 (see all 62):
    hsa-miR-4291 hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-136 hsa-miR-4328 hsa-miR-513a-5p hsa-miR-128
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TNRC18

    Additional mRNA sequence: 

    AB058759.1 AF075006.1 AK027341.1 AK057263.1 AY129022.1 BC029940.1 BC036932.1 BC068099.1 
    BC131808.1 BC140723.1 U80753.1 

    24/25 DOTS entries (see all 25):

    DT.448669  DT.111505  DT.405454  DT.100748928  DT.424900  DT.121042462  DT.97798144  DT.97860843 
    DT.95285475  DT.100748222  DT.95248584  DT.99928805  DT.70103177  DT.95077342  DT.95219479  DT.100031653 
    DT.40201797  DT.40316671  DT.449527  DT.100857479  DT.121042455  DT.121042510  DT.40232367  DT.92476533 

    24/233 AceView cDNA sequences (see all 233):

    AI811305 AI198110 R49939 BU538834 AA400049 BE890954 AI564053 AI868645 
    AA974367 BM827518 AI469086 AW136114 BC068099 AI292162 BU742912 AI338804 
    AI744934 AW630193 AI362980 AI274581 BM746776 AI950932 AA077157 CA748613 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TNRC18 expression in normal human tissues (normalized intensities)      TNRC18 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGACAGGGCA
    TNRC18 Expression
    About this image


    TNRC18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Blood (Hematopoietic System)
             pre Conventional Dendritic Cells Peripheral Blood

    See TNRC18 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TNRC18

    SOURCE GeneReport for Unigene cluster: Hs.520638
        SABiosciences Custom PCR Arrays for TNRC18
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TNRC18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TNRC18 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tnrc181 , 5 trinucleotide repeat containing 181, 5 82.19(n)1
    85.48(a)1
      5 (81.73 cM)5
    2318611  NM_001122730.21  NP_001116202.21 
     1427503805 
    chicken
    (Gallus gallus)
    Aves TNRC181 trinucleotide repeat containing 18 67.71(n)
    64.47(a)
      416482  XM_001233345.2  XP_001233346.2 
    lizard
    (Anolis carolinensis)
    Reptilia TNRC186
    Uncharacterized protein
    51(a)
    1 ↔ 1
    GL343591.1(375849-426961)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.192852 Transcribed sequences 76.96(n)    AL846285.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5595141 uncharacterized protein LOC559514 57.58(n)
    53.08(a)
      559514  XM_002661214.2  XP_002661260.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta wge6
    winged eye
    16(a)
    1 → many
    3R(18536605-18546872)


    ENSEMBL Gene Tree for TNRC18 (if available)
    TreeFam Gene Tree for TNRC18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TNRC18 gene
    BAHCC12  

    TNRC18 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for TNRC18
    PGOHUM00000245713 PGOHUM00000232790 PGOHUM00000232791 PGOHUM00000233274 PGOHUM00000233275


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3216 SNPs in TNRC18 are shown (see all 3216)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1819111981,2
    C--5345950(+) CCTCCC/TGAGTA 1 -- int10--------
    rs1858413621,2
    --5346052(+) AACTCC/TTGGCC 1 -- int10--------
    rs1480885971,2
    C--5346075(+) CCCGCC/GTCGGC 1 -- int10--------
    rs47205781,2
    C,H--5346196(+) ctgacC/Ttcaag 1 -- int17Minor allele frequency- T:0.08NA WA CSA 13
    rs624411531,2
    --5346244(+) ACAGGC/TGTGAG 1 -- int10--------
    rs624411541,2
    C,F--5346298(+) GTCACC/TGCCCC 1 -- int12Minor allele frequency- T:0.05WA NA 238
    rs624411551,2
    C,F--5346308(+) CTGCAC/TGCGTG 1 -- int13Minor allele frequency- T:0.04WA NA EA 358
    rs782200961,2
    C--5346455(+) TTTTTA/TATGAA 1 -- ut310--------
    rs1902518921,2
    --5346474(+) ACACAC/GAATTT 1 -- ut310--------
    rs339601261,2
    C--5346508(+) AAAAA-/A/AA  
            
    CCAAT
    2 -- ut311NA 2

    HapMap Linkage Disequilibrium report for TNRC18 (5346421 - 5465045 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/23 variations for TNRC18 (see all 23):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv436904CNV Insertion17901297
    esv26599CNV Loss19812545
    nsv887396CNV Loss21882294
    nsv508443CNV Loss20534489
    nsv830889CNV Loss17160897
    nsv887391CNV Loss21882294
    nsv510064CNV Loss20534489
    nsv887402CNV Loss21882294
    dgv7140n71CNV Loss21882294
    dgv7141n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TNRC18 for disorders           About MalaCards

    TNRC18 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TNRC18

    Export disorders for TNRC18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TNRC18 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with TNRC18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNAs with long CAG trinucleotide repeats from human brain. (PubMed id 9225980)1, 2, 3 Margolis R.L.... Ross C.A. (1997)
    2. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (2007)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    4. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (2001)
    5. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)
    6. The functional interactome landscape of the human hist one deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (2013)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84629 HGNC: 11962 AceView: KIAA1856 Ensembl:ENSG00000182095 euGenes: HUgn84629
    ECgene: TNRC18 H-InvDB: TNRC18

    (According to HUGE)
    About This Section
    HUGE: KIAA1856

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TNRC18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TNRC18 gene:
    Search GeneIP for patents involving TNRC18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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