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Aliases for TNRC18 Gene

Aliases for TNRC18 Gene

  • Trinucleotide Repeat Containing 18 2 3 5
  • Long CAG Trinucleotide Repeat-Containing Gene 79 Protein 3 4
  • CAGL79 3 4
  • KIAA1856 4
  • TNRC18A 3

External Ids for TNRC18 Gene

Previous GeneCards Identifiers for TNRC18 Gene

  • GC07M004997
  • GC07M061674
  • GC07M005097
  • GC07M005120
  • GC07U901564
  • GC07M062665

Summaries for TNRC18 Gene

GeneCards Summary for TNRC18 Gene

TNRC18 (Trinucleotide Repeat Containing 18) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is BAHCC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNRC18 Gene

Genomics for TNRC18 Gene

Regulatory Elements for TNRC18 Gene

Promoters for TNRC18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TNRC18 on UCSC Golden Path with GeneCards custom track

Genomic Location for TNRC18 Gene

Chromosome:
7
Start:
5,306,790 bp from pter
End:
5,425,414 bp from pter
Size:
118,625 bases
Orientation:
Minus strand

Genomic View for TNRC18 Gene

Genes around TNRC18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNRC18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNRC18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNRC18 Gene

Proteins for TNRC18 Gene

  • Protein details for TNRC18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15417-TNC18_HUMAN
    Recommended name:
    Trinucleotide repeat-containing gene 18 protein
    Protein Accession:
    O15417
    Secondary Accessions:
    • A8MX41
    • Q96JH1
    • Q96K91

    Protein attributes for TNRC18 Gene

    Size:
    2968 amino acids
    Molecular mass:
    314519 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55047.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TNRC18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNRC18 Gene

Proteomics data for TNRC18 Gene at MOPED

Post-translational modifications for TNRC18 Gene

  • Ubiquitination at Lys 2328
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TNRC18 Gene

Domains & Families for TNRC18 Gene

Gene Families for TNRC18 Gene

Protein Domains for TNRC18 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TNRC18 Gene

Graphical View of Domain Structure for InterPro Entry

O15417

UniProtKB/Swiss-Prot:

TNC18_HUMAN :
  • Contains 1 BAH domain.
Domain:
  • Contains 1 BAH domain.
genes like me logo Genes that share domains with TNRC18: view

Function for TNRC18 Gene

genes like me logo Genes that share phenotypes with TNRC18: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNRC18 Gene

Localization for TNRC18 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TNRC18 Gene COMPARTMENTS Subcellular localization image for TNRC18 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for TNRC18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with TNRC18: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TNRC18 Gene

Pathways & Interactions for TNRC18 Gene

SuperPathways for TNRC18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TNRC18 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TNRC18 Gene

Drugs & Compounds for TNRC18 Gene

No Compound Related Data Available

Transcripts for TNRC18 Gene

Unigene Clusters for TNRC18 Gene

Trinucleotide repeat containing 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNRC18 Gene

No ASD Table

Relevant External Links for TNRC18 Gene

GeneLoc Exon Structure for
TNRC18
ECgene alternative splicing isoforms for
TNRC18

Expression for TNRC18 Gene

mRNA expression in normal human tissues for TNRC18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TNRC18 Gene

This gene is overexpressed in Bone (22.8), Pancreatic juice (15.6), Breast (9.2), Platelet (8.3), and Monocytes (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TNRC18 Gene



SOURCE GeneReport for Unigene cluster for TNRC18 Gene Hs.520638

genes like me logo Genes that share expression patterns with TNRC18: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TNRC18 Gene

Orthologs for TNRC18 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNRC18 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TNRC18 35
  • 86.44 (n)
  • 87.73 (a)
TNRC18 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNRC18 35
  • 87.52 (n)
  • 90.12 (a)
TNRC18 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnrc18 35
  • 81.34 (n)
  • 83.85 (a)
Tnrc18 16
Tnrc18 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TNRC18 35
  • 98.5 (n)
  • 98.65 (a)
TNRC18 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnrc18 35
  • 80.12 (n)
  • 82.34 (a)
oppossum
(Monodelphis domestica)
Mammalia TNRC18 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNRC18 36
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNRC18 35
  • 66.82 (n)
  • 61.97 (a)
TNRC18 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNRC18 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491423 35
  • 56.25 (n)
  • 55.1 (a)
Str.19285 35
zebrafish
(Danio rerio)
Actinopterygii tnrc18 36
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta wge 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4643 36
  • 29 (a)
OneToMany
Species with no ortholog for TNRC18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNRC18 Gene

ENSEMBL:
Gene Tree for TNRC18 (if available)
TreeFam:
Gene Tree for TNRC18 (if available)

Paralogs for TNRC18 Gene

Paralogs for TNRC18 Gene

genes like me logo Genes that share paralogs with TNRC18: view

Variants for TNRC18 Gene

Sequence variations from dbSNP and Humsavar for TNRC18 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs12671708 - 5,370,794(+) GCACC(A/C/G)CCACA reference, missense
rs13388 -- 5,351,587(+) CCAGC(C/T)GGGGA intron-variant
rs1131911 -- 5,307,104(-) ACCCC(A/G)CCAAG utr-variant-3-prime
rs1131914 -- 5,307,054(-) AGGGA(A/G)AGAAG utr-variant-3-prime
rs1131915 -- 5,307,052(-) GGAGA(A/G)AAGAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TNRC18 Gene

Variant ID Type Subtype PubMed ID
nsv436904 CNV Insertion 17901297
nsv887390 CNV Loss 21882294
nsv887391 CNV Loss 21882294
nsv830889 CNV Loss 17160897
nsv8034 CNV Gain 18304495
nsv887392 CNV Loss 21882294
nsv823996 CNV Gain 20364138
dgv7138n71 CNV Loss 21882294
dgv7139n71 CNV Loss 21882294
nsv887396 CNV Loss 21882294
nsv887399 CNV Loss 21882294
esv994032 CNV Gain 20482838
dgv7140n71 CNV Loss 21882294
dgv7141n71 CNV Loss 21882294
nsv887402 CNV Loss 21882294
dgv7142n71 CNV Loss 21882294
esv26599 CNV Loss 19812545
nsv510064 CNV Loss 20534489
nsv887407 CNV Loss 21882294
nsv508443 CNV Loss 20534489
esv8871 CNV Gain 19470904
nsv526194 CNV Gain 19592680
nsv823997 CNV Gain 20364138

Variation tolerance for TNRC18 Gene

Gene Damage Index Score: 16.62; 97.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TNRC18 Gene

HapMap Linkage Disequilibrium report
TNRC18
Human Gene Mutation Database (HGMD)
TNRC18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNRC18 Gene

Disorders for TNRC18 Gene

Relevant External Links for TNRC18

Genetic Association Database (GAD)
TNRC18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TNRC18

No disorders were found for TNRC18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNRC18 Gene

Publications for TNRC18 Gene

  1. cDNAs with long CAG trinucleotide repeats from human brain. (PMID: 9225980) Margolis R.L. … Ross C.A. (Hum. Genet. 1997) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PMID: 23667531) Cox J.L. … Rizzino A. (PLoS ONE 2013) 3
  4. The functional interactome landscape of the human histone deacetylase family. (PMID: 23752268) Joshi P. … Cristea I.M. (Mol. Syst. Biol. 2013) 3
  5. Common variants in left/right asymmetry genes and pathways are associated with relative hand skill. (PMID: 24068947) Brandler W.M. … Paracchini S. (PLoS Genet. 2013) 3

Products for TNRC18 Gene

Sources for TNRC18 Gene

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